WO1995024504A1 - Marqueurs genetiques utilises conjointement pour le diagnostic de la maladie d'alzheimer, methode et kit de diagnostic - Google Patents
Marqueurs genetiques utilises conjointement pour le diagnostic de la maladie d'alzheimer, methode et kit de diagnostic Download PDFInfo
- Publication number
- WO1995024504A1 WO1995024504A1 PCT/FR1995/000259 FR9500259W WO9524504A1 WO 1995024504 A1 WO1995024504 A1 WO 1995024504A1 FR 9500259 W FR9500259 W FR 9500259W WO 9524504 A1 WO9524504 A1 WO 9524504A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- apoe
- apo
- allele
- disease
- short
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Definitions
- the present invention relates to genetic markers used jointly for the diagnosis of Alzheimer's disease.
- the authors of the present invention carried out a study on two populations of different origins, one of a late-onset form of Alzheimer's disease (after 65 years), the other of a form of onset early Alzheimer's disease (before age 65), which made it possible to establish a significant increase in the two groups of at least two of the following genetic markers: allele APOE ⁇ 4, allele D19S178 short and allele APO Long eyelash.
- allele APOE ⁇ 4 allele D19S178 short and allele APO Long eyelash.
- the localization on chromosome 19 of the markers APOE, APO C11 (APO C2) and D19S178 is known and described in particular by Willia son et al. (Cyto Genetic and Cell Genetic 1991, vol. 58, p. 1678).
- the biological sample can be whole blood, the leukocyte fraction of the blood or a tissue from which DNA can be extracted, or a biological fluid.
- primers may be suitable, the criterion for selecting the primers being that they allow the amplification of the parts of the APOE, D19S178 and APO C11 genes comprising the respective polymorphisms: region 112-158 of APOE, 5 'end of APO C11.
- the alleles sought in particular D19S178 and APO Cil long, can be demonstrated by determining the length of the amplified fragments, for example by electrophoresis on polyacrylamide gel or by determining the sequence of the amplified fragment.
- the estimated frequencies were compared to those expected based on the Pearson ⁇ 2 equilibrium or the Fischer exact test.
- APOE polymorphism analyzed as a biallelic marker (allele 4 against allele 2 or 3)
- the expected frequencies were calculated for controls presenting the product corresponding to the allelic frequencies for each polymorphism.
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95911377A EP0749498B1 (fr) | 1994-03-07 | 1995-03-06 | Marqueurs genetiques utilises conjointement pour le diagnostic de la maladie d'alzheimer, methode et kit de diagnostic |
DE69503885T DE69503885T2 (de) | 1994-03-07 | 1995-03-06 | Gemeinschaftlich verwendete genetische marker zur diagnostik der alzheimerschen krankheit, methode und diagnostischer reagenziensatz |
CA002184635A CA2184635C (fr) | 1994-03-07 | 1995-03-06 | Marqueurs genetiques utilises conjointement pour le diagnostic de la maladie d'alzheimer, methode et kit de diagnostic |
JP52326695A JP3662585B2 (ja) | 1994-03-07 | 1995-03-06 | アルツハイマー病の診断のための共同で用いられる遺伝標識形質、並びに診断方法及びキット |
US08/702,548 US5942392A (en) | 1994-03-07 | 1995-03-06 | Genetic markers used jointly for the diagnosis of Alzheimer's disease, and diagnostic method and kit |
DK95911377T DK0749498T3 (da) | 1994-03-07 | 1995-03-06 | Genetiske markører, der i forening anvendes til diagnose af Alzheimer's sygdom, metode og diagnosekit |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9402603A FR2716894B1 (fr) | 1994-03-07 | 1994-03-07 | Marqueurs génétiques utilisés conjointement pour le diagnostic de la maladie d'Alzheimer, méthode et kit de diagnostic. |
FR94/02603 | 1994-03-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1995024504A1 true WO1995024504A1 (fr) | 1995-09-14 |
Family
ID=9460754
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR1995/000259 WO1995024504A1 (fr) | 1994-03-07 | 1995-03-06 | Marqueurs genetiques utilises conjointement pour le diagnostic de la maladie d'alzheimer, methode et kit de diagnostic |
Country Status (9)
Country | Link |
---|---|
US (1) | US5942392A (fr) |
EP (1) | EP0749498B1 (fr) |
JP (1) | JP3662585B2 (fr) |
AT (1) | ATE169343T1 (fr) |
CA (1) | CA2184635C (fr) |
DE (1) | DE69503885T2 (fr) |
DK (1) | DK0749498T3 (fr) |
FR (1) | FR2716894B1 (fr) |
WO (1) | WO1995024504A1 (fr) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2765591A1 (fr) * | 1997-07-01 | 1999-01-08 | Pasteur Institut | Procede de diagnostic de la maladie d'alzheimer |
ES2128265A1 (es) * | 1997-06-04 | 1999-05-01 | Euroespes S L | Kit genetico para la caracterizacion molecular de la enfermedad de alzheimer. |
EP1012339A1 (fr) * | 1997-09-12 | 2000-06-28 | Bristol-Myers Squibb Company | Procede permettant de determiner la propension a developper tardivement la maladie d'alzheimer |
WO2001004349A2 (fr) * | 1999-07-09 | 2001-01-18 | Institut Pasteur De Lille | Diagnostic ou pronostic de la maladie d'alzheimer et composition therapeutique pour la prevention ou le traitement de la maladie d'alzheimer |
EP1876244A1 (fr) * | 2005-04-04 | 2008-01-09 | Asubio Pharma Co., Ltd. | Calcul du risque relatif de survenue d'une dermité atopique par analyse du polymorphisme génique |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6022683A (en) * | 1996-12-16 | 2000-02-08 | Nova Molecular Inc. | Methods for assessing the prognosis of a patient with a neurodegenerative disease |
US6251587B1 (en) | 1997-12-16 | 2001-06-26 | Nova Molecular, Inc. | Method for determining the prognosis of a patient with a neurological disease |
US6703228B1 (en) | 1998-09-25 | 2004-03-09 | Massachusetts Institute Of Technology | Methods and products related to genotyping and DNA analysis |
EP1001037A3 (fr) * | 1998-09-28 | 2003-10-01 | Whitehead Institute For Biomedical Research | Pre-selection et isolement d'un polymorphisme de mononucleotide |
DE60326153D1 (de) * | 2002-07-30 | 2009-03-26 | David Gladstone Inst | Verfahren zur diagnose von morbus alzheimer |
EP1623996A1 (fr) * | 2004-08-06 | 2006-02-08 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Procédé amélioré de selection d'une protéine desirée d'une bibliothéque. |
WO2006110621A2 (fr) * | 2005-04-11 | 2006-10-19 | Cornell Research Foundation, Inc. | Biomarqueurs multiplexes destines a diagnostiquer la maladie d'alzheimer chez un sujet |
EP1877576B1 (fr) | 2005-04-12 | 2013-01-23 | 454 Life Sciences Corporation | Procedes de determination de variantes de sequence utilisant un sequencage des amplicons |
US20060228721A1 (en) * | 2005-04-12 | 2006-10-12 | Leamon John H | Methods for determining sequence variants using ultra-deep sequencing |
EP2121984A2 (fr) * | 2007-03-16 | 2009-11-25 | 454 Life Sciences Corporation | Système et procédé pour détecter des variants qui résistent à un médicament contre le vih |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994009155A1 (fr) * | 1992-10-13 | 1994-04-28 | Duke University | Procedes de detection de la maladie d'alzheimer |
-
1994
- 1994-03-07 FR FR9402603A patent/FR2716894B1/fr not_active Expired - Fee Related
-
1995
- 1995-03-06 CA CA002184635A patent/CA2184635C/fr not_active Expired - Fee Related
- 1995-03-06 JP JP52326695A patent/JP3662585B2/ja not_active Expired - Fee Related
- 1995-03-06 DE DE69503885T patent/DE69503885T2/de not_active Expired - Lifetime
- 1995-03-06 WO PCT/FR1995/000259 patent/WO1995024504A1/fr active IP Right Grant
- 1995-03-06 EP EP95911377A patent/EP0749498B1/fr not_active Expired - Lifetime
- 1995-03-06 AT AT95911377T patent/ATE169343T1/de not_active IP Right Cessation
- 1995-03-06 DK DK95911377T patent/DK0749498T3/da active
- 1995-03-06 US US08/702,548 patent/US5942392A/en not_active Expired - Lifetime
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994009155A1 (fr) * | 1992-10-13 | 1994-04-28 | Duke University | Procedes de detection de la maladie d'alzheimer |
Non-Patent Citations (8)
Title |
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A.M. SAUNDERS ET AL.: "Association of apolipoprotein E allele epsilonç with late-onset familial and sporadic Alzheimer's disease", NEUROLOGY, vol. 43, no. 8, EDGELL COMMUN. INC., DULUTH, MINN, US;, pages 1467 - 1472 * |
E.H. CORDER ET AL.: "Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer disease in late onset families", SCIENCE, vol. 261, 13 August 1993 (1993-08-13), AAAS, WASHINGTON, DC, US;, pages 921 - 923 * |
G.D. SCHELLENBERG ET AL.: "Genetic association and linkage analysis of the apolipoprotein CII locus and familial Alzheimer's disease", ANNALS OF NEUROLOGY, vol. 31, no. 2, LISSLE, BROWN AND COMPANY, BOSTON, MA, US;, pages 223 - 227 * |
H.H. ROPERS AND M.A. PERICAK-VANCE: "Report of the committee on the genetic constitution of chromosome 19", CYTOGENETICS AND CELL GENETICS, vol. 58, no. 1-4, KARGER, NEW YORK, US;, pages 751 - 784 * |
J.L. WEBER AND P.E. MAY: "Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction", AM J. HUMAN GENETICS, vol. 44, no. 3, AM. SOC. HUM. GENET., UNIV. CHICAGO PRESS, US;, pages 388 - 396 * |
M.-C. CHARTIER-HARLIN ET AL.: "Apolipoprotein E, epsilon4 allele as a major risk factor for sporadic early and late onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region", HUMAN MOLECULAR GENETICS, vol. 3, no. 4, OXFORD UNIVERSITY PRESS, CAMBRIDGE, UK;, pages 569 - 574 * |
N. ANWAR ET AL.: "Apolipoprotein E-epsilon4 allele and Alzheimer's disease", THE LANCET, vol. 342, no. 8882, 20 November 1993 (1993-11-20), LANCET,LONDON,UK, pages 1308 - 1309 * |
W.J. SCHRITTMACHER ET AL.: "Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease", PROC. NATL. ACAD SCI., vol. 90, no. 5, 1 March 1993 (1993-03-01), NATL. ACAD SCI., WASHINGTON, DC, US;, pages 1977 - 1981 * |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2128265A1 (es) * | 1997-06-04 | 1999-05-01 | Euroespes S L | Kit genetico para la caracterizacion molecular de la enfermedad de alzheimer. |
FR2765591A1 (fr) * | 1997-07-01 | 1999-01-08 | Pasteur Institut | Procede de diagnostic de la maladie d'alzheimer |
WO1999001574A1 (fr) * | 1997-07-01 | 1999-01-14 | Institut Pasteur De Lille | Procede de diagnostic de la maladie d'alzheimer |
EP1012339A1 (fr) * | 1997-09-12 | 2000-06-28 | Bristol-Myers Squibb Company | Procede permettant de determiner la propension a developper tardivement la maladie d'alzheimer |
EP1012339A4 (fr) * | 1997-09-12 | 2004-06-30 | Bristol Myers Squibb Co | Procede permettant de determiner la propension a developper tardivement la maladie d'alzheimer |
WO2001004349A2 (fr) * | 1999-07-09 | 2001-01-18 | Institut Pasteur De Lille | Diagnostic ou pronostic de la maladie d'alzheimer et composition therapeutique pour la prevention ou le traitement de la maladie d'alzheimer |
EP1074634A1 (fr) * | 1999-07-09 | 2001-02-07 | Institut Pasteur De Lille | Procédé pour le diagnostic ou le prognostic de la maladie d'Alzheimer: Composition therapeutique pour la prévention ou le traitement de la maladie d'Alzheimer |
WO2001004349A3 (fr) * | 1999-07-09 | 2001-05-25 | Pasteur Institut | Diagnostic ou pronostic de la maladie d'alzheimer et composition therapeutique pour la prevention ou le traitement de la maladie d'alzheimer |
EP1876244A1 (fr) * | 2005-04-04 | 2008-01-09 | Asubio Pharma Co., Ltd. | Calcul du risque relatif de survenue d'une dermité atopique par analyse du polymorphisme génique |
EP1876244A4 (fr) * | 2005-04-04 | 2009-09-23 | Asubio Pharma Co Ltd | Calcul du risque relatif de survenue d'une dermité atopique par analyse du polymorphisme génique |
US8071307B2 (en) | 2005-04-04 | 2011-12-06 | Asubio Pharma Co., Ltd. | Method of detecting relative risk for the onset of atopic dermatitis by gene single nucleotide polymorphism analysis |
Also Published As
Publication number | Publication date |
---|---|
DE69503885T2 (de) | 1999-04-22 |
CA2184635C (fr) | 2008-11-18 |
DE69503885D1 (de) | 1998-09-10 |
ATE169343T1 (de) | 1998-08-15 |
US5942392A (en) | 1999-08-24 |
JP3662585B2 (ja) | 2005-06-22 |
FR2716894A1 (fr) | 1995-09-08 |
JPH09511138A (ja) | 1997-11-11 |
DK0749498T3 (da) | 1999-05-10 |
CA2184635A1 (fr) | 1995-09-14 |
FR2716894B1 (fr) | 1996-05-24 |
EP0749498B1 (fr) | 1998-08-05 |
EP0749498A1 (fr) | 1996-12-27 |
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