WO1995022378A1 - Device for treatment of incontinence of urine - Google Patents

Device for treatment of incontinence of urine Download PDF

Info

Publication number
WO1995022378A1
WO1995022378A1 PCT/FI1995/000087 FI9500087W WO9522378A1 WO 1995022378 A1 WO1995022378 A1 WO 1995022378A1 FI 9500087 W FI9500087 W FI 9500087W WO 9522378 A1 WO9522378 A1 WO 9522378A1
Authority
WO
WIPO (PCT)
Prior art keywords
sensors
frame part
sensor
sides
frame
Prior art date
Application number
PCT/FI1995/000087
Other languages
French (fr)
Inventor
Arto Remes
Original Assignee
Arto Remes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arto Remes filed Critical Arto Remes
Priority to DE69524071T priority Critical patent/DE69524071T2/en
Priority to EP95908971A priority patent/EP0749340B1/en
Priority to JP52162395A priority patent/JP3604391B2/en
Priority to AT95908971T priority patent/ATE209058T1/en
Priority to CA002183427A priority patent/CA2183427C/en
Priority to DK95908971T priority patent/DK0749340T3/en
Priority to AU17098/95A priority patent/AU1709895A/en
Publication of WO1995022378A1 publication Critical patent/WO1995022378A1/en
Priority to US09/267,613 priority patent/US6289894B1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0521Genital electrodes
    • A61N1/0524Vaginal electrodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/389Electromyography [EMG]
    • A61B5/391Electromyography [EMG] of genito-urinary organs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0507Electrodes for the digestive system
    • A61N1/0512Anal electrodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • AHUMAN NECESSITIES
    • A63SPORTS; GAMES; AMUSEMENTS
    • A63BAPPARATUS FOR PHYSICAL TRAINING, GYMNASTICS, SWIMMING, CLIMBING, OR FENCING; BALL GAMES; TRAINING EQUIPMENT
    • A63B23/00Exercising apparatus specially adapted for particular parts of the body
    • A63B23/20Exercising apparatus specially adapted for particular parts of the body for vaginal muscles or other sphincter-type muscles
    • AHUMAN NECESSITIES
    • A63SPORTS; GAMES; AMUSEMENTS
    • A63BAPPARATUS FOR PHYSICAL TRAINING, GYMNASTICS, SWIMMING, CLIMBING, OR FENCING; BALL GAMES; TRAINING EQUIPMENT
    • A63B2213/00Exercising combined with therapy
    • A63B2213/004Exercising combined with therapy with electrotherapy
    • AHUMAN NECESSITIES
    • A63SPORTS; GAMES; AMUSEMENTS
    • A63BAPPARATUS FOR PHYSICAL TRAINING, GYMNASTICS, SWIMMING, CLIMBING, OR FENCING; BALL GAMES; TRAINING EQUIPMENT
    • A63B2230/00Measuring physiological parameters of the user
    • A63B2230/08Measuring physiological parameters of the user other bio-electrical signals
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00Surgery
    • Y10S128/25Artificial sphincters and devices for controlling urinary incontinence

Definitions

  • an alternative for stimulation is incorporated into the device.
  • ne ⁇ cessary devices for emitting electrical pulses to the pelvic floor muscles are attached to the device in a known manner.

Abstract

The invention relates to a device for treating incontinence, which device includes a frame part (1) and a, at least partially tubular, sensor part (2) fastened at an angle in relation to the frame part, having sensors (3) on its sides for measuring the function of the pelvic floor muscles. According to the invention: the sensor part is detachably attached to the frame part (1), which makes it exchangeable regarding to every patient; the sensors (3) are placed on the sides of the sensor-part-tube, on both sides of the center of the side; and the sensors (3) are electrodes which are arranged to measure the muscle activity of the pelvic floor muscles with the help of the electrical signal produced by them.

Description

DEVICE FOR TREATMENT OF INCONTINENCE OF URINE
The invention relates to a device for treating incontinence, which device includes a frame part and a, at least partially tubular, sensor part fastened at an angle in relation to the frame part, having sensors on its sides for measuring the func¬ tion of the pelvic floor muscles.
Incontinence means reduction of the ability to restrain urine. The main reason to the problem is the weakening of the pelvic floor muscles and the reduction of their ability to be activat¬ ed. This may be influenced by a lot of different reasons, for example overweight, psychological reasons and as one reason, the reduction of the restraining ability caused by the delivery of children. It is essential when treating incontinence to re¬ store the muscle strength and the muscle control of the pati¬ ents pelvic floor muscles. This may be realized through prac¬ tice or electrical stimulation of the muscles.
These days different kinds of devices exist with which it is possible to exercise the pelvic floor muscles and/or measure their activity. The device is placed in the vagina and when the muscles are contracted the condition of the muscles is eluci¬ dated with the help of the data transmitted by the sensors. By repeating the contracting exercises the muscle strength is grown to a level where the problem to hold the urine disap¬ pears. With the training made possible with the devices it may be possible to avoid surgery.
Several problems are connected with the known devices. The de¬ vices are generally intended for use only in research and lab¬ oratory conditions and are not possible to use at home. The de¬ vices are often staff-shaped and their use is troublesome. In addition, some devices have a thickening at the end of the staffs which is an inconvenience to the measurements in stand-
CORRECTED ing and squatting position. When using some devices it is not possible to get them completely clean in spite of the steri¬ lization or exchange of the sensor part, but secretions from the body may transfer from the sensor part to the frame part and stay in cavities in the device. Another problem is the con- veniency to handle and the safety to use the device. A dis¬ advantage is also that the device is not easy to adjust to the user.
Devices also exist where a pressure sensor is placed inside a flexible tube which is placed into the vagina. This kind of measurement with pressure is not accurate enough, since it is possible to create pressure in the vagina by squeezing the feet or the muscles in the abdomen or the seat. A disadvantage when using pressure sensors is that it is not possible to discover a situation where the muscles on one side are functioning worse than the muscles on the other side.
The object of the invention is to bring forward a device for treating incontinence with which disadvantages connected to present devices are removed. The object of the invention is especially to bring forward a device which is easy to use both at home and in laboratory conditions and which is safe, relia¬ ble and hygienic. Further, the object of the invention is to bring forward a device which is adjustable for different users or which the user may adjust to different values in different phases of the treatment.
The object of the invention is achieved with a device characte¬ rized by that described in the claims.
According to the invention the sensor part is detachably at¬ tached to the frame part, the sensors are placed on the sides of the sensor-part-tube, on both sides of the center of the side, and the sensors are electrodes which are arranged to measure the muscle activity of the pelvic floor muscles with the help of the electrical signal produced by them. A sensor part according to the invention is a so called disposable part which is exchanged after each patient so that the device is hygienic and safe. When using the device at home it is possi¬ ble, when the same patient is using the device, to continuously use the sensor part several times in a row. In this case it shall be carefully cleaned after use. The frame part is only exchanged if it is broken. An electronic case is placed inside the frame part, inside which adjustment and functioning organs are placed.
The measurement taking place with the apparatus is preferably based on electromyographic measurement (EMG) . The muscle ac¬ tivation of the pelvic floor expressed with a rms-EMG-signal is from a few micro volts to about 50-80μV. The electrode plate pairs functioning as sensors register the sum-potential of the contracting muscle and thus the signal accurately describes the activation capacity of the pelvic floor muscles on both sides. The measurement results are collected separately from each side.
A device with a frame part according to the invention is ac¬ curately placed in its position in the vagina by placing it in such a position that the frame part extends forward. In this case the sensors are in the desired way at the muscles to be examined or exercised. An additional advantage is that the frame part is spacious enough and can be equipped with the ne¬ cessary measurement and control electronics and possibly with a displaying device. Still, the device is so small that it can be placed under the trousers.
In the advantageous embodiment of the invention the sensor part is an integrated moulded part. The sensors are situated on the side surface of the tubular part during the moulding, forming a part of the construction. When the sensor part is moulded as an integrated part no secretions from the body may enter the sen¬ sor part and therethrough continue to the frame part. Thus the device is sufficiently hygienic all the time.
In the second embodiment of the invention a cover belongs to the lower part of the sensor part. The lower surface of the co¬ ver is placed on the upper surface of the frame part. The cover protects the frame part so that the frame part does not come into contact with the secretions from the body. The cover is placed at an angle compared with the other part of the sensor part.
The contact connections between the sensors and the frame part are advantageously placed at the frame part. In this way the risk of contamination is small.
In an advantageous additional embodiment of the invention the tube of the sensor part is converging essentially over its whole length l°-5° against the tip. The tube does not press against the user too much and does not cause pain when using the device. The device may be used in a lying-down, a standing and a squatting position.
In an advantageous embodiment of the invention the sensors are placed on the sides of the tube on both sides of the center of the side symmetrically and at about an 50°-70° angle compared with each other seen from the center of the tube. When the de¬ vice is accurately placed in its position with the help of the invention, reliable knowledge is acquired of the muscles on both sides separately.
In the following the invention is explained in more detail by referring to the accompanying drawings where Figure 1 shows an embodiment of a device according to the in¬ vention seen at an angle from below when the sensor part and the frame part are separated from each other
Figure 2 shows another embodiment of a device according to the invention seen at an angle from below when the sensorpart and the frame part are separated from each other
Figure 3 shows a section of a device according to figure 2 and
Figure 4 shows a section A-A according to figure 3.
A device according to the figures includes a frame part 1 and a sensor part 2 detachably attachable to the frame part. A tu¬ bular part belongs to the sensor part. The sensors 3 are fast¬ ened on the sides of the tubular part. The sensors are ordinary measuring-sensors suitable for the purpose and their number may vary in different embodiments. The sensors are sufficiently long so that they are suitable for different women and are placed at the pelvic floor muscles when the device is in its place. At the lower part of the tubular part are formed a widening-part extending away from and downwards from the tubu¬ lar part, and a protective edge extending downwards from the widening-part. The widening-part and the protective edge form together the cover 4. The cover is arranged at a blunt angle compared with the rest of the sensor part. The tube is converg¬ ing about l°-5° against the tip, which makes it easy to place into the vagina. The material in the sensor is known material which resists disinfection and cleaning.
The sensors 3 are placed on the sides of the tube on both sides of the center in the manner as shown in figure . In this em¬ bodiment they are at about an 60° angle compared with each other. The sensor part is moulded from homogenous material in such a way that the sensors are first placed in the mould and the plastic part is moulded around them so that the sensors are integrated in the construction so that it does not have any cracks or slits.
The tube in the sensor part has in this embodiment a circular cross-section but the cross-section may be elliptical in other embodiments.
In accordance with figure 3 contacting parts 9 are formed at the sides of the tube, with which parts 9 the information given by the sensors is transferred to the frame part 1. An electro¬ nic case 5 is placed inside the frame part, which case includes printed circuits and electronic parts for adjustment and use of the device. The frame part is essentially flat, and in the shown embodiments a signalling device and a display unit 8 are placed on its lower surface.
In an embodiment according to figure 1 the device is connected with a cable 10 to a using apparatus which provides it with en¬ ergy. The display unit and the signalling device may in this case be placed in the frame part or in a separate display unit. In an embodiment according to figure 2 the energy needed to use the device is provided by an accumulator 7 or a battery which is fastened to the frame part in such a way that it reaches into the tube in the frame part. When using an accumulator or a battery the device may be used in home conditions or in a la¬ boratory without an outer energy source. In one embodiment a transmitter unit is connected to the frame part for sending a message without using a cable, and a separate display unit and/ or a signalling device which may for example be a device that is to be placed on the wrist belongs to the device.
The signalling device 8 is arranged to be programmed in a man¬ ner known in itself to a desired value and to be calibrated to a pre set value. The device has in this case pre set standard levels, for example the levels shown in figures 1 and 2 marked with one and two circles. In the third position it is possible to set suitable individual practice levels for the whole de¬ vice. The standard levels may then be changed when the practice is progressing and when trying to reach a new practice level.
One embodiment of the invention is a device intended for men. On men the measurement is done in the anal orifice into which the pelvic floor muscles reach. The functional principle of the device stays the same, but the outer dimensions of the sen¬ sor is different from those on the models intended for women.
In an additional embodiment of the invention an alternative for stimulation is incorporated into the device. In this case, ne¬ cessary devices for emitting electrical pulses to the pelvic floor muscles are attached to the device in a known manner.
The invention is not limited to the shown advantageous embodi¬ ments. It may vary within the scope of the inventive idea as stated in the claims.

Claims

1. Device for treating incontinence, which device includes a frame part(l) and a, at least partially tubular, sensor part (2) fastened at an angle in relation to the frame part, having sensors (3) on its sides for measuring the function of the pel¬ vic floor muscles characterized in that the
- sensorpart (2) is detachably attached to the frame part (1), which makes it exchangeable regarding to every patient.
- the sensors (3) are placed on the sides of the sensor-part- tube, on both sides of the center of the side, and
- the sensors (3) are electrodes, which are arranged to measure the muscle activity of the pelvic floor muscles with the help of the electrical signal produced by them.
2. A device according to claim 1, characterized in that the sensor part (2) is an integrated moulded part. The sensors (3) are situated on the side surface of the tubular part during the moulding, forming a part of the construction.
3. A device according to claim 1 or 2, characterized in that a cover (4) belongs to the lower part of the sensor part (2) . The lower surface of the cover is placed on the upper surface of the frame part.
4. A device according to one of claims 1-3, characterized in that the tube of the sensor part is converging essentially over its whole length about l°-5° against the tip.
5. A device according to one of claims 1-4, characterized in that the contact connections (6) between the sensors (3) and the frame part are placed at the frame part.
6. A device according to one of claims 1-5, characterized in that the sensors (3) are placed symmetrically and at about an 50°-70° angle compared with each other.
7. A device according to one of claims 1-6, characterized in that the device includes a battery (7) or a corresponding de¬ vice, which can be fastened on the frame and placed inside the sensor part.
8. A device according to one of claims 1-7, characterized in that the device includes a signalling device and/or a display unit (8) placed on the lower surface of the frame part.
9. A device according to claim 8, characterized in that the signalling device and/or the display unit (8) are arranged to be programmed to a desired value and to be calibrated to a pre set value.
10.A device according to one of claims 1-9, characterized in that an electronic case is placed inside the frame part, which case includes the adjustment and functioning organs of the de¬ vice.
PCT/FI1995/000087 1994-02-21 1995-02-21 Device for treatment of incontinence of urine WO1995022378A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DE69524071T DE69524071T2 (en) 1994-02-21 1995-02-21 DEVICE FOR TREATING URINE CONTINENCE
EP95908971A EP0749340B1 (en) 1994-02-21 1995-02-21 Device for treatment of incontinence of urine
JP52162395A JP3604391B2 (en) 1994-02-21 1995-02-21 Urinary incontinence treatment device
AT95908971T ATE209058T1 (en) 1994-02-21 1995-02-21 DEVICE FOR TREATING URINARY INCONTINENCE
CA002183427A CA2183427C (en) 1994-02-21 1995-02-21 Device for treatment of incontinence of urine
DK95908971T DK0749340T3 (en) 1994-02-21 1995-02-21 Device for the treatment of urinary incontinence
AU17098/95A AU1709895A (en) 1994-02-21 1995-02-21 Device for treatment of incontinence of urine
US09/267,613 US6289894B1 (en) 1994-02-21 1999-03-15 Device for treatment of incontinence of urine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI940799A FI98045C (en) 1994-02-21 1994-02-21 Device for incontinence treatment
FI940799 1994-02-21

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US08/873,461 Continuation US5881731A (en) 1994-02-21 1997-06-12 Device for treatment of incontinence of urine

Publications (1)

Publication Number Publication Date
WO1995022378A1 true WO1995022378A1 (en) 1995-08-24

Family

ID=8540164

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FI1995/000087 WO1995022378A1 (en) 1994-02-21 1995-02-21 Device for treatment of incontinence of urine

Country Status (12)

Country Link
US (1) US6289894B1 (en)
EP (1) EP0749340B1 (en)
JP (1) JP3604391B2 (en)
AT (1) ATE209058T1 (en)
AU (1) AU1709895A (en)
CA (1) CA2183427C (en)
DE (1) DE69524071T2 (en)
DK (1) DK0749340T3 (en)
ES (1) ES2166815T3 (en)
FI (1) FI98045C (en)
PT (1) PT749340E (en)
WO (1) WO1995022378A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2754717A1 (en) * 1996-10-23 1998-04-24 Carprieaux Jean Paul Probe for urino-gynaecological re-education or vaginal treatment
US7785608B2 (en) 2002-08-30 2010-08-31 Wyeth Holdings Corporation Immunogenic compositions for the prevention and treatment of meningococcal disease
US8101194B2 (en) 2001-10-11 2012-01-24 Wyeth Llc Immunogenic compositions for the prevention and treatment of meningococcal disease
US9757443B2 (en) 2010-09-10 2017-09-12 Wyeth Llc Non-lipidated variants of Neisseria meningitidis ORF2086 antigens
US11896823B2 (en) 2017-04-04 2024-02-13 Btl Healthcare Technologies A.S. Method and device for pelvic floor tissue treatment

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003279942A1 (en) * 2002-10-10 2004-05-04 Uab Research Foundation Luminal directional force measurement and electrical stimulation probe
AU2011268245B2 (en) 2010-06-17 2015-09-17 InControl Medical, LLC Urinary incontinence device and method and stimulation device and method
USD670398S1 (en) 2011-01-06 2012-11-06 InControl Medical, LLC Stimulation device
USD669592S1 (en) 2011-01-06 2012-10-23 InControl Medical, LLC Medical device
US9776040B2 (en) 2012-11-30 2017-10-03 LELO Inc. Exercising kegel muscles using preprogrammed exercise programs
USD716463S1 (en) 2014-02-27 2014-10-28 InControl Medical, LLC Stimulation device
US11027120B2 (en) 2018-09-28 2021-06-08 InControl Medical, LLC Urinary incontinence treatment device and method for using the same
US20220323295A1 (en) * 2021-04-09 2022-10-13 Abraham Morgentaler Method of Treating Urinary Dysfunction

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2119516A (en) * 1981-06-08 1983-11-16 John Delbert Perry Vaginal myograph
US4953563A (en) * 1986-06-20 1990-09-04 Howard Kaiser Protective disposable sheath for muscle monitor
DE4038853A1 (en) * 1989-11-30 1991-06-06 Steindorf Susanne Ruth Functional diagnosis appts. for continence organ - has rod-shaped probe inserted into canal, pressure sensor and positioning device connected to display, data processor
US5154177A (en) * 1991-04-12 1992-10-13 Eugene Eisman Myographic electrode
WO1992020283A1 (en) * 1991-05-20 1992-11-26 Cardio Design Pty Ltd A perineometer
WO1993017619A1 (en) * 1992-03-09 1993-09-16 Alexander Pauser Device for monitoring the contractibility of the pelvic floor muscles
WO1994015667A1 (en) * 1993-01-11 1994-07-21 Brent Carman Method of varying appropriate muscle strength of a person to alleviate urinary or fecal urgency or incontinence or vaginal or bladder spasms

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Publication number Priority date Publication date Assignee Title
US4909263A (en) 1988-10-28 1990-03-20 C. R. Bard, Inc. Method and apparatus for fitting a patient with a body cavity electrode
DE4140055C2 (en) 1990-11-30 1995-08-03 Steindorf Susanne Ruth Device for the functional diagnosis of the continental organ
US5370671A (en) * 1991-03-26 1994-12-06 Empi, Inc. Incontinence electrode apparatus
US5385577A (en) * 1992-11-12 1995-01-31 Empi, Inc. Electrode for activating pelvic reflexes
US5423329A (en) 1994-04-15 1995-06-13 Rehab Centers Of America, Inc. Method of treatment for urinary incontinence

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2119516A (en) * 1981-06-08 1983-11-16 John Delbert Perry Vaginal myograph
US4953563A (en) * 1986-06-20 1990-09-04 Howard Kaiser Protective disposable sheath for muscle monitor
DE4038853A1 (en) * 1989-11-30 1991-06-06 Steindorf Susanne Ruth Functional diagnosis appts. for continence organ - has rod-shaped probe inserted into canal, pressure sensor and positioning device connected to display, data processor
US5154177A (en) * 1991-04-12 1992-10-13 Eugene Eisman Myographic electrode
WO1992020283A1 (en) * 1991-05-20 1992-11-26 Cardio Design Pty Ltd A perineometer
WO1993017619A1 (en) * 1992-03-09 1993-09-16 Alexander Pauser Device for monitoring the contractibility of the pelvic floor muscles
WO1994015667A1 (en) * 1993-01-11 1994-07-21 Brent Carman Method of varying appropriate muscle strength of a person to alleviate urinary or fecal urgency or incontinence or vaginal or bladder spasms

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2754717A1 (en) * 1996-10-23 1998-04-24 Carprieaux Jean Paul Probe for urino-gynaecological re-education or vaginal treatment
US8101194B2 (en) 2001-10-11 2012-01-24 Wyeth Llc Immunogenic compositions for the prevention and treatment of meningococcal disease
US7785608B2 (en) 2002-08-30 2010-08-31 Wyeth Holdings Corporation Immunogenic compositions for the prevention and treatment of meningococcal disease
US9757443B2 (en) 2010-09-10 2017-09-12 Wyeth Llc Non-lipidated variants of Neisseria meningitidis ORF2086 antigens
US11896823B2 (en) 2017-04-04 2024-02-13 Btl Healthcare Technologies A.S. Method and device for pelvic floor tissue treatment

Also Published As

Publication number Publication date
CA2183427C (en) 2005-08-09
AU1709895A (en) 1995-09-04
PT749340E (en) 2002-05-31
EP0749340A1 (en) 1996-12-27
FI98045B (en) 1996-12-31
ES2166815T3 (en) 2002-05-01
US6289894B1 (en) 2001-09-18
FI98045C (en) 1997-04-10
ATE209058T1 (en) 2001-12-15
CA2183427A1 (en) 1995-08-24
FI940799A0 (en) 1994-02-21
FI940799A (en) 1995-08-22
JP3604391B2 (en) 2004-12-22
DK0749340T3 (en) 2002-03-18
EP0749340B1 (en) 2001-11-21
DE69524071D1 (en) 2002-01-03
DE69524071T2 (en) 2002-07-18
JPH09508838A (en) 1997-09-09

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