WO1995020401A1 - Polyclonal antibody libraries - Google Patents
Polyclonal antibody libraries Download PDFInfo
- Publication number
- WO1995020401A1 WO1995020401A1 PCT/US1995/001197 US9501197W WO9520401A1 WO 1995020401 A1 WO1995020401 A1 WO 1995020401A1 US 9501197 W US9501197 W US 9501197W WO 9520401 A1 WO9520401 A1 WO 9520401A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- library
- antibodies
- cells
- igg
- group
- Prior art date
Links
- 0 C*NC(C)*(C)C1CC(*c2cc(C)ccc2)CC1 Chemical compound C*NC(C)*(C)C1CC(*c2cc(C)ccc2)CC1 0.000 description 4
Classifications
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT95909384T ATE243745T1 (en) | 1994-01-31 | 1995-01-27 | LIBRARIES OF POLYCLONAL ANTIBODIES |
DK02000290T DK1231268T3 (en) | 1994-01-31 | 1995-01-27 | Polyclonal antibody libraries |
DE69531148T DE69531148T2 (en) | 1994-01-31 | 1995-01-27 | LIBRARIES MADE OF POLYCLONAL ANTIBODIES |
DK95909384T DK0744958T3 (en) | 1994-01-31 | 1995-01-27 | Polyclonal antibody libraries |
EP95909384A EP0744958B1 (en) | 1994-01-31 | 1995-01-27 | Polyclonal antibody libraries |
AU17364/95A AU1736495A (en) | 1994-01-31 | 1995-01-27 | Polyclonal antibody libraries |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18936094A | 1994-01-31 | 1994-01-31 | |
US08/189,360 | 1994-01-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1995020401A1 true WO1995020401A1 (en) | 1995-08-03 |
WO1995020401A9 WO1995020401A9 (en) | 1995-09-14 |
Family
ID=22696993
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1995/001197 WO1995020401A1 (en) | 1994-01-31 | 1995-01-27 | Polyclonal antibody libraries |
Country Status (9)
Country | Link |
---|---|
US (2) | US5789208A (en) |
EP (2) | EP1231268B1 (en) |
AT (2) | ATE300610T1 (en) |
AU (1) | AU1736495A (en) |
DE (2) | DE69531148T2 (en) |
DK (2) | DK0744958T3 (en) |
ES (2) | ES2247204T3 (en) |
PT (2) | PT1231268E (en) |
WO (1) | WO1995020401A1 (en) |
Cited By (514)
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WO2002002641A1 (en) | 2000-06-16 | 2002-01-10 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to blys |
WO2002064612A2 (en) | 2001-02-09 | 2002-08-22 | Human Genome Sciences, Inc. | Human g-protein chemokine receptor (ccr5) hdgnr10 |
WO2002097033A2 (en) | 2001-05-25 | 2002-12-05 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to trail receptors |
WO2003055515A1 (en) * | 2001-12-21 | 2003-07-10 | Arius Research, Inc. | Individualized anti-cancer antibodies |
WO2003086458A1 (en) | 2002-04-12 | 2003-10-23 | Medimmune, Inc. | Recombinant anti-interleukin-9 antibodies |
US6657048B2 (en) | 1999-10-08 | 2003-12-02 | Arius Research, Inc. | Individualized anti-cancer antibodies |
WO2004009618A2 (en) | 2002-07-18 | 2004-01-29 | Crucell Holland B.V. | Recombinant production of mixtures of antibodies |
WO2005063817A2 (en) * | 2003-12-22 | 2005-07-14 | Amgen Inc. | Methods for identifying functional antibodies |
WO2005077042A2 (en) | 2004-02-09 | 2005-08-25 | Human Genome Sciences, Inc. | Albumin fusion proteins |
WO2006007850A1 (en) * | 2004-07-20 | 2006-01-26 | Symphogen A/S | Anti-rhesus d recombinant polyclonal antibody and methods of manufacture |
JP2006515520A (en) * | 2003-01-07 | 2006-06-01 | シムフォゲン・アクティーゼルスカブ | Method for producing recombinant polyclonal protein |
WO2006089133A2 (en) | 2005-02-15 | 2006-08-24 | Duke University | Anti-cd19 antibodies and uses in oncology |
US7101549B2 (en) | 1999-06-30 | 2006-09-05 | Millennium Pharmaceuticals, Inc. | Glycoprotein VI and uses thereof |
WO2006102095A2 (en) | 2005-03-18 | 2006-09-28 | Medimmune, Inc. | Framework-shuffling of antibodies |
WO2006106323A1 (en) | 2005-04-05 | 2006-10-12 | Ucb Pharma S.A. | Method for obtaining antibodies |
WO2007002543A2 (en) | 2005-06-23 | 2007-01-04 | Medimmune, Inc. | Antibody formulations having optimized aggregation and fragmentation profiles |
WO2007014433A1 (en) | 2005-08-03 | 2007-02-08 | Grains Research & Development Corporation | Polysaccharide synthases |
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WO2007024715A2 (en) | 2005-08-19 | 2007-03-01 | Abbott Laboratories | Dual variable domain immunoglobin and uses thereof |
WO2007056352A2 (en) | 2005-11-07 | 2007-05-18 | The Scripps Research Institute | Compositions and methods for controlling tissue factor signaling specificity |
US7252821B2 (en) | 1999-10-08 | 2007-08-07 | Arius Research Inc. | Cancerous disease modifying antibodies |
WO2007141280A2 (en) | 2006-06-06 | 2007-12-13 | Oxford Genome Sciences (Uk) Ltd | Proteins |
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WO2008105797A2 (en) | 2006-06-30 | 2008-09-04 | Bristol-Myers Squibb Company | Polynucleotides encoding novel pcsk9 variants |
EP1972639A2 (en) | 2007-03-07 | 2008-09-24 | Cell Signaling Technology, Inc. | Reagents for the detection of protein phosphorylation in carcinoma signaling pathways |
US7429646B1 (en) | 1995-06-05 | 2008-09-30 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor-like 2 |
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EP1983000A2 (en) | 2003-11-21 | 2008-10-22 | UCB Pharma, S.A. | Method for the treatment of multiple sclerosis by inhibiting IL-17 activity |
EP1983002A2 (en) | 2007-04-19 | 2008-10-22 | Peter Hornbeck | Tyrosine phosphorylation sites and antibodies specific for them |
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WO2008136694A1 (en) | 2007-05-04 | 2008-11-13 | Technophage, Investigação E Desenvolvimento Em Biotecnologia, Sa | Engineered rabbit antibody variable domains and uses thereof |
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EP1231268A3 (en) | 2002-08-21 |
EP1231268B1 (en) | 2005-07-27 |
PT1231268E (en) | 2005-11-30 |
ES2247204T3 (en) | 2006-03-01 |
DE69534347D1 (en) | 2005-09-01 |
DK0744958T3 (en) | 2003-10-20 |
DK1231268T3 (en) | 2005-11-21 |
ATE243745T1 (en) | 2003-07-15 |
DE69534347T2 (en) | 2006-05-24 |
AU1736495A (en) | 1995-08-15 |
EP0744958B1 (en) | 2003-06-25 |
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EP1231268A2 (en) | 2002-08-14 |
EP0744958A4 (en) | 1997-07-30 |
PT744958E (en) | 2003-11-28 |
DE69531148D1 (en) | 2003-07-31 |
US5789208A (en) | 1998-08-04 |
DE69531148T2 (en) | 2004-04-29 |
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ATE300610T1 (en) | 2005-08-15 |
US6335163B1 (en) | 2002-01-01 |
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