WO1995011977A3 - A NEW RIBOSOME-INACTIVATING PROTEIN ISOLATED FROM THE PLANT $i(BRYONIA DIOICA) - Google Patents

A NEW RIBOSOME-INACTIVATING PROTEIN ISOLATED FROM THE PLANT $i(BRYONIA DIOICA) Download PDF

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Publication number
WO1995011977A3
WO1995011977A3 PCT/US1994/012382 US9412382W WO9511977A3 WO 1995011977 A3 WO1995011977 A3 WO 1995011977A3 US 9412382 W US9412382 W US 9412382W WO 9511977 A3 WO9511977 A3 WO 9511977A3
Authority
WO
WIPO (PCT)
Prior art keywords
bryodin
ribosome
inactivating protein
plant
type
Prior art date
Application number
PCT/US1994/012382
Other languages
French (fr)
Other versions
WO1995011977A2 (en
Inventor
Clay B Siegall
Susan L Gawlak
Hans Marquardt
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Priority to EP94932092A priority Critical patent/EP0725823A1/en
Priority to AU80945/94A priority patent/AU684571B2/en
Priority to JP7512852A priority patent/JPH09509043A/en
Publication of WO1995011977A2 publication Critical patent/WO1995011977A2/en
Publication of WO1995011977A3 publication Critical patent/WO1995011977A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • A61K47/6819—Plant toxins
    • A61K47/6825—Ribosomal inhibitory proteins, i.e. RIP-I or RIP-II, e.g. Pap, gelonin or dianthin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The present invention discloses a new ribosome-inactivating protein, bryodin 2, isolated from the plant Bryonia dioica. This ribosome-inactivating protein (RIP) is a type I RIP having a single polypeptide chain and no cellular receptor domain. Like many type I RIPs, bryodin 2 has a molecular weight of about 27,000 daltons and pI of 9.5. Bryodin 2 differs from previously identified ribosome-inactivating protein in its amino acid composition, amino acid sequence, and toxicity in vitro and in vivo. Bryodin 2 is useful, as are other type I ribosome-inactivating proteins, as an abortifacient, immunomodulator, anti-tumor or anti-viral agent. Compositions comprising bryodin 2 as an immunoconjugate or fusion molecule are particularly useful to kill cells of a target population.
PCT/US1994/012382 1993-10-25 1994-10-25 A NEW RIBOSOME-INACTIVATING PROTEIN ISOLATED FROM THE PLANT $i(BRYONIA DIOICA) WO1995011977A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP94932092A EP0725823A1 (en) 1993-10-25 1994-10-25 A NEW RIBOSOME-INACTIVATING PROTEIN ISOLATED FROM THE PLANT $i(BRYONIA DIOICA)
AU80945/94A AU684571B2 (en) 1993-10-25 1994-10-25 A new ribosome-inactivating protein isolated from the plant (bryonia dioica)
JP7512852A JPH09509043A (en) 1993-10-25 1994-10-25 A novel ribosome-inactivating protein isolated from the plant Bryonia dioica

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14189193A 1993-10-25 1993-10-25
US08/324,301 US5597569A (en) 1993-10-25 1994-10-20 Bryodin 2 a ribosome-inactivating protein isolated from the plant Bryonia dioica
US08/141,891 1994-10-20
US08/324,301 1994-10-20

Publications (2)

Publication Number Publication Date
WO1995011977A2 WO1995011977A2 (en) 1995-05-04
WO1995011977A3 true WO1995011977A3 (en) 1995-05-26

Family

ID=26839543

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/012382 WO1995011977A2 (en) 1993-10-25 1994-10-25 A NEW RIBOSOME-INACTIVATING PROTEIN ISOLATED FROM THE PLANT $i(BRYONIA DIOICA)

Country Status (7)

Country Link
US (1) US5597569A (en)
EP (1) EP0725823A1 (en)
JP (1) JPH09509043A (en)
AU (1) AU684571B2 (en)
CA (1) CA2174943A1 (en)
IL (1) IL111393A0 (en)
WO (1) WO1995011977A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10500670A (en) * 1994-05-13 1998-01-20 エクラゲン リミテッド Improved peptide delivery or implications for peptide delivery
US5541110A (en) * 1994-05-17 1996-07-30 Bristol-Myers Squibb Cloning and expression of a gene encoding bryodin 1 from Bryonia dioica
US6410690B1 (en) 1995-06-07 2002-06-25 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
IT1286663B1 (en) * 1996-06-27 1998-07-15 Ministero Uni Ricerca Scient E PROTEIN CAPABLE OF INHIBITING RIBOSOMIAL ACTIVITY, ITS PREPARATION AND USE AS A CHEMICAL OR RECOMBINANT IMMUNOCONUGATE AND SEQUENCE OF CDNA
AU8040898A (en) 1997-06-06 1998-12-21 Tanox Pharma B.V. Type-1 ribosome-inactivating protein
DE19740180A1 (en) * 1997-09-12 1999-03-18 Basf Ag Nickel (0) phosphonite complex useful in production of organic nitriles
US6251392B1 (en) * 1997-10-20 2001-06-26 Epicyte Pharmaceuticals, Inc. Epithelial cell targeting agent
NZ510358A (en) * 1998-08-11 2002-09-27 Large Scale Biology Corp Method for recovering proteins from the interstitial fluid of plant tissues
US6946129B1 (en) 1999-06-08 2005-09-20 Seattle Genetics, Inc. Recombinant anti-CD40 antibody and uses thereof
US20010051147A1 (en) * 2000-03-27 2001-12-13 Van De Winkel Jan G.J. Methods for immunostimulation using binding agents for the Fc receptor of immunoglobulin A
US7622446B2 (en) * 2001-04-18 2009-11-24 The Open University Polypeptides, derivatives and uses thereof
US7491702B2 (en) * 2001-04-18 2009-02-17 The Open University Polypeptides related to amyloid precursor protein, pharmaceutical compositions thereof, and methods of treatment using the same
EP1720569B1 (en) * 2004-02-27 2014-10-29 Immune System Therapeutics Ltd Target for b-cell disorders
DE602006017690D1 (en) 2005-05-26 2010-12-02 Genentech Inc HUMANIZED ANTIBODIES TO CD40 AND METHOD FOR THEIR USE
WO2009026660A1 (en) 2007-08-30 2009-03-05 Walter And Eliza Hall Institute Of Medical Research Dendritic cell marker and uses thereof
US8530628B2 (en) 2007-09-28 2013-09-10 Welcome Receptor Antibodies Pty Ltd Diagnosis and treatment of diseased and damaged tissue
EP2864362A4 (en) * 2012-06-26 2015-11-18 Biovalence Sdn Bhd Anticancer treatment
WO2014003536A1 (en) * 2012-06-26 2014-01-03 Biovalence Sdn. Bhd. Dosage regime of fusion compounds
WO2023196892A1 (en) 2022-04-06 2023-10-12 The Trustees Of The University Of Pennsylvania Passive immunization with anti- aav neutralizing antibodies to prevent off-target transduction of intrathecally delivered aav vectors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3726380A1 (en) * 1986-08-14 1988-02-18 Erba Farmitalia A NEW INHIBITOR FOR PROTEIN SYNTHESIS
EP0390040A1 (en) * 1989-03-31 1990-10-03 ITALFARMACO S.p.A. Ribosome inactivating proteins and derivatives thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8701095A (en) * 1987-05-08 1988-12-01 Nido Universal Machines Bv WHEEL FOR A SPREADING EQUIPMENT.
IL94872A (en) * 1989-06-30 1995-03-30 Oncogen Monoclonal or chimeric antibodies reactive with human carcinomas, recombinant proteins comprising their antigen binding region, pharmaceutical compositions and kits comprising said antibodies and methods for imaging human carcinoma using same
US5242813A (en) * 1990-10-12 1993-09-07 The United States Of America As Represented By The Department Of Health And Human Services Mouse monoclonal antibodies specific for normal primate tissue, malignant human cultural cell lines human tumors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3726380A1 (en) * 1986-08-14 1988-02-18 Erba Farmitalia A NEW INHIBITOR FOR PROTEIN SYNTHESIS
EP0390040A1 (en) * 1989-03-31 1990-10-03 ITALFARMACO S.p.A. Ribosome inactivating proteins and derivatives thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FRIEDMAN ET AL.: "Antitumor activity of the single-chain immunotoxin BR96 sFv-PE40 against established breast and lung tumor xenografts", THE JOURNAL OF IMMUNOLOGY, vol. 150, no. 7, 1 April 1993 (1993-04-01), pages 3054 - 3061 *
SIEGALL ET AL.: "Characterization of ribosome-inactivating proteins isolated from Bryonia dioica and their utility as carcinoma-reactive immunoconjugates", BIOCONJUGATE CHEMISTRY, vol. 5, no. 5, September 1994 (1994-09-01), WASHINGTON US *

Also Published As

Publication number Publication date
IL111393A0 (en) 1995-03-30
EP0725823A1 (en) 1996-08-14
AU684571B2 (en) 1997-12-18
WO1995011977A2 (en) 1995-05-04
US5597569A (en) 1997-01-28
AU8094594A (en) 1995-05-22
CA2174943A1 (en) 1995-05-04
JPH09509043A (en) 1997-09-16

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