WO1995005737A1

WO1995005737A1 - Alcohol-based hand disinfectant with a skin care component

Info

Publication number: WO1995005737A1
Application number: PCT/EP1994/002840
Authority: WO
Inventors: Ulrich Möllers; Hanns Pietsch; Wolfgang Stenzel; B. Walz
Original assignee: Bode Chemie Gmbh & Co.
Priority date: 1993-08-27
Filing date: 1994-08-26
Publication date: 1995-03-02
Also published as: DE4328828A1

Abstract

An alcohol-based hand disinfectant is characterized in that it contains lanolin alcohols and/or cholesterol (cholesterin).

Description

Alcoholic hand disinfectant with skin care component

The invention relates to a

Hand disinfectant, based on at least one alcohol and a skin care component.

Disinfection of the hands is inevitable in many areas and in some cases prescribed by law, e.g. in hospitals, medical practices, in the food industry and in the pharmaceutical industry. Most people who disinfect their hands have to disinfect them very often. This leads to constant, very heavy stress on the skin.

Furthermore, there are currently two methods for performing hand disinfection:

Alcoholic hand disinfection is common in Germany. The hands are rubbed with a defined amount of the alcoholic preparation for a defined time. The alcohol or alcohols evaporate, the non-volatile components such as skin care substances and / or non-volatile antimicrobial substances, so-called remanent agents, remain on the skin. There is no extraction or elution of skin components with this procedure.

Washing hand disinfection (scrub method) is common in many countries. The hands are washed with an active soap, in many cases treated with a brush. Soap and soluble skin components are extracted and washed off. This washing method strains the skin to a considerable extent, so that rough and open hands are part of the professional profile of people who have to wash their hands or disinfect them while washing.

In contrast, the alcoholic "rub-in method" is much gentler on the skin, but if it is carried out or used continuously, it also leads to the skin drying out if no additional skin care substances are contained in the disinfectant. Such skin care substances are usually: eg glycerin, dexpanthenol or chamomile extract, isopropyl myristate, ethyl myristate, isopropyl palmitate, isopropyl lactate, 2-ethylhexyl-2-ethylhexanoate, oleyl lactate, heptamethylnonane, paraffin oil, petroleum jelly, hexalacetate, bisacololanolate, bisacolate tranolacid, Citric acid, pyrrolidone carboxylic acid or undecylenic acid. The effect of such a skin care substance is said to leave a pleasant feeling on the skin immediately after use, is intended to counteract maceration of the skin when using rubber gloves and is ultimately intended to ensure that long-term use does not result in skin damage but, if possible, has a nourishing effect becomes. In addition to the skin protection substances, other antimicrobial substances are usually present, preferably those that are not volatile. These have the task, on the one hand, of filling the microbial activity gaps of the alcohols and, on the other hand, of guaranteeing a microbiostatic or microbicidal action after the alcohol (s) has evaporated. Such active ingredients, also called remanent active ingredients, are, for example, quaternary ammonium compounds (QAV's or Quats), guanine derivatives, such as chlorhexidine digluconate, phenols such as o-phenylphenol, cresols such as tetrabromocresol or m-chloro-p-cresol. All microbicidal or microbiostatic compounds with a correspondingly low vapor pressure and, according to their frequent use, good skin tolerance are possible, as are the organic acids already mentioned: lactic acid, citric acid, tartaric acid, pyrrolidonecarboxylic acid, undecylenic acid. Dyes and fragrances may also be present.

A typical alcoholic hand disinfectant for rubbing in therefore consists of alcohol or mixtures of alcohols, if appropriate a remanent active ingredient, skin care substance and water and, if appropriate, perfume, dyes and other auxiliaries.

When selecting the skin protection agent, the type of alcohol and the remanent active ingredient are usually taken into account, which means that the composition of the skin care ingredients is based on the properties of the active ingredients. It has been shown that skin care substances are already known for hand disinfectants based on 1-propanol and 2-propanol, but that suitable skin care substances are lacking for ethanolic disinfectants. All on the market Hand disinfectants based on ethanol leave a dry and brittle feeling on the hands after the ethanol has evaporated, have a degreasing effect and increase transepidermal water loss (TEWL).

It was therefore an object of the invention to find a skin care substance which, in alcoholic and especially in ethanolic hand disinfectants, gives the skin a pleasant "grip" and non-brittle skin feel after the ethanol has evaporated, and vice versa in the case of an operation lasting several hours after the surgery has been put on. Gloves, no maceration of the hands, which restores the lipid layer and reduces the TEWL. Even in long-term use, there should be no skin damage. At the same time, the skin care substance should also have the same properties in propanolic hand disinfectants and also in products with ethanol-propanol mixtures.

This object is achieved by the present invention.

It has surprisingly been found that wool wax alcohols, also called lanolin alcohols, and / or cholesterol meet these requirements and act as skin care components or skin care substances.

The invention therefore relates to an alcoholic hand disinfectant or hand disinfectant based on alcohol, which contains wool wax alcohols and / or cholesterol (cholesterol).

Wool wax alcohols are preferred. Mixtures with cholesterol can also be used. The disinfectant can be used for surgical and hygienic hand disinfection.

The invention also relates to the use of wool wax alcohols and / or cholesterol as skin care substances in alcoholic ones

Hand disinfectants and their use in the manufacture of such agents.

Wool wax alcohols (English name: Wool (Wax) Alcohols, Lanolinalcohols) are often described in the literature (e.g. CAS No. 8027-33-6) and are commercially available in different degrees of purity. Wool wax alcohols are also listed in the German Pharmacopoeia (DAB 9, Commentary Volume 3, 1986, pages 3534 - 3535) with properties and test methods. Natural wool wax alcohols, which are obtainable by saponification of the wool wax, are particularly preferred. A well-known commercial product is p

Eucerit (Beiersdorf).

Wool wax alcohols are formed, for example, by saponification of wool wax or wool fat. The usual wool wax alcohols are, for example, a mixture of several aliphatic and alicyclic and cyclic alcohols with a share of approx. 75% C ₂ 7_28 ~ ^sterols and 25% aliphatic alcohols: e.g. the sterols cholesterol, dihydrocholesterol, 7-0xocholesterol, cholestane-3, 5 , 6-triol, cholest-7-en-3-ol, cholest-3,5-dien-7-one, lanosterol, dihydrolanosterol, agnosterol, dihydrognosterol,

7, 11-dioxolanost-8-en-3-ol, 7-0xolanost-8-en-3-ol and, for example, the aliphatic alcohols octadecanol to triacontanol, 16-methylheptadecanol to 24-methylpentacosanol, (+) 14-methylhexadecanol to (+) 24 methylhexacosanol hexadecanediol- (1, 2), and iso-octadecanediol to iso-tetracosanediol.

The wool wax alcohols can be present, for example, in amounts of 0.001 to 1% by weight, in particular 0.005-0.5% by weight, based on the total weight of the disinfectant. Quantities of 0.01 to 1.0% by weight, in particular 0.01 to 0.3% by weight, are also preferred, based in each case on the total weight.

It has surprisingly been found that the wool wax alcohols according to the invention, preferably in these proportions both in the ethanolic and in the propanolic preparations, give the desired care effect described above.

It is surprising that even the smallest amounts show the pleasant skin effect, whereby the effect is stronger in ethanol than in 1- or 2-propanol. This means that in purely ethanolic preparations the desired proportion is preferably in the lower range from 0.01 to 0.1% and that the desired proportion of wool wax alcohols can increase the more propanols are present in the mixture. In this context, the term "desired proportion" is to be determined subjectively and means the amount that is still felt on the skin as pleasant and not lubricating.

At least one alcohol, preferably ethanol, 1-propanol and / or 2-propanol or mixtures thereof, are used as alcohol or alcoholic active substances in the disinfectants according to the invention. The proportion of alcohols is, for example, 50 to 90, preferably at least 55% by weight, in particular 55 to 85% by weight, based on the total agent.

The propanols can e.g. are dosed lower because of their greater bactericidal activity, while ethanol is preferably dosed higher because of its lower bactericidal activity.

The disinfectants according to the invention can furthermore preferably contain one or more additional disinfectant active ingredients, in particular remanent active ingredients.

Such active substances are preferably selected from the group of quaternary ammonium compounds, guanidini compounds, phenols, per compounds and / or organic acids. The substances listed above are particularly suitable.

The additional disinfectant substances can be contained in amounts of 0 to 2% by weight based on the total agent.

Furthermore, the disinfectant according to the invention can additionally contain one or more of the customary skin care substances, preferably the aforementioned skin care substances. These skin care substances can be present in amounts of 0 to 2% by weight, preferably 0.5 to 2% by weight, based on the total composition.

Furthermore, water is preferably contained in the hand disinfectants according to the invention, preferably in amounts of 10 to 60% by weight, in particular 10 to 50% by weight on the entire mean. Demineralized water is preferred, but in particular aqua purificata (DAB 9).

In addition, auxiliaries and additives e.g. Dyes, colorants, wetting agents, surfactants and perfume may be included, e.g. in amounts 0.1 to 0.5% by weight.

Preferred hand disinfectants according to the invention have the following composition:

Percent by weight

Alcohols (active ingredient) 90 - 50 but especially 85 - 55

Wool wax alcohols 0.001 - 1

Retentive substances 0 - 2 other skin care substances 0 - 2

Excipients 0 - 0.5

Water 10-50, especially 15-45

A hand disinfectant that is particularly preferred

Percent by weight

Ethanol 80

Wool wax alcohols 0.05 heptamethylnonane, in particular

2,2,4,4,6,8,8-heptamethylnonane 0.2

2-ethylhexyl-2-ethylhexanoate 0.2

Pyrrolidone carboxylic acid 0.05

Pyrrolidone carboxylic acid Na salt 0.1

Tetradecanol 0.1

2-butanone 0.08 Water ad 100

consists.

Wool wax alcohols are known and are used in cosmetics in many ointments and creams as emulsifiers (see Pharmaceutical Substance List, 7th Edition, Trim - 7, pp. 35 - 36). In all cases, they are aqueous preparations, some with low alcohol levels.

It was not to be expected for these substances that a skin-caring effect with such small amounts in alcoholic preparations with high, e.g. more than 50 wt .-% alcohol content would appear.

The disinfectants according to the invention are generally produced in conventional devices by mixing the constituents. It may be advisable to heat individual components or the mixture until clear solutions are achieved.

The wool wax alcohols are not soluble in water and only slightly soluble in alcohols. If you want to get a clear solution, it is advisable to pre-dissolve or melt it in suitable lipophilic components. Otherwise, opaque but effective emulsions are obtained, especially if the proportion is greater than 0.5%. Suitable lipophilic substances are e.g. Isopropyl myristate, ethyl yristate, isopropyl palmitate, isopropyl lactate,

2-ethylhexyl-2-ethylhexanoate, oleyl lactate, squalane or heptamethylnonane, in particular 2,2,4,4,6,8,8-heptamethylnonane, paraffin oil, petroleum jelly. With small proportions of wool wax alcohols, the agents according to the invention are produced in the following way. The wool wax alcohols are dissolved in the desired amount of alcohol. The alcoholic solution is then added to the water and, if appropriate, further ingredients, with stirring. It can be helpful to raise the temperature to around 40 ° C, especially when dissolving the wax alcohols.

The invention also relates to the use of at least one alcoholic active substance and wool wax alcohols and / or cholesterol in a hand disinfectant or the use of wool wax alcohols and / or cholesterol for the production of such disinfectants.

The application of the invention

Hand disinfectants are preferably made in accordance with the guidelines of the German Society for Hygiene and Microbiology (DGHM).

The invention is explained in more detail in the following examples:

Unless otherwise stated, all amounts and percentages in the context of the present application are based on the weight and the total composition of the preparation.

All experiments were carried out on subjects in the presence of a dermatologist.

In the following examples, the commercial product Eucerit (from Beiersdorf, Hamburg) was used as "lanolin alcohol". Is cholesterol (cholesterol) instead of eucerit used, the same good results are achieved.

example 1

A solution of 50 parts by weight of lanolin alcohol, 100 parts by weight of 1-tetradecanol, 200 parts by weight of 2,2,4,4,6,8,8, -heptamethylnonane was obtained by stirring and heating to about 40 ° C. The solution was after cooling in a solution of 14,580 parts by weight of water, 150 parts by weight Mecetroniu etilsulfat (INN), 84 840 parts by weight of ethanol ( ^'96% denatured with 1% 2-butanone) slowly added dropwise while stirring at room temperature, then 30 parts by weight of perfume and 50 parts by weight of dye solution were added. The mixture was then stirred for a further 30 minutes. The following test was carried out with this mixture: 5 test persons rubbed their hands with at least three times 3 ml in the course of 5 minutes, such that each time after the evaporation of a 3 ml portion, the next portion was added until after 5 minutes of treatment approx. 9 to 30 ml of the solution had been consumed. The test subjects then put a surgical glove on one hand and kept it on for over 8 hours. During this time, 2 subsequent disinfections are carried out in the same way. On the gloved hand, an assessment by the test subject himself and an assessment of the skin by an experienced dermatologist was carried out immediately after the alcohol had evaporated and after 3 hours. The gloved skin was also assessed after 8 hours, after removing the glove.

Result: pleasant, non-slip skin feel, no damage, no maceration. Comparative example

A solution was prepared which corresponded to Example 1 in all its constituents, but without the proportion of lanolin alcohol or cholesterol. The same test was carried out with this preparation as in Example 1.

Result: Dry skin feeling, attacked hands in two test subjects.

Example 2 ^•

A solution of 100 parts by weight of lanolin alcohol, 50 parts by weight of tetradecanol, 300 parts by weight of squalane and 100 parts by weight of isopropyl myristate was prepared by stirring and heating to about 40 ° C. After cooling, this solution was slowly dissolved in a solution composed of 150 parts by weight of benzalkonium chloride, 14,380 parts by weight of water and 84,840 parts by weight of ethanol (96%, denatured with 1% 2-butanone) with stirring at room temperature added dropwise, then 30 parts by weight of perfume and 50 parts by weight of dye solution.

This mixture was also tested on test persons in the same way as Example 1.

Result: pleasant "grip" feeling, no damage or impairment In game 3

A solution of 150 parts by weight of lanolin alcohol, 200 parts by weight of dexpanthenol and 200 parts by weight of squalane and 50 parts by weight of bisabolol was prepared by stirring and heating to 40 ° C. After cooling, this solution was denatured in a solution of 200 parts by weight of o-phenylphenol, 14 280 parts by weight of water, 12 120 parts by weight of 1-propanol, 72 720 parts by weight of ethanol (96% strength) with 1% methyl ethyl ketone) was added dropwise at room temperature, then 30 parts by weight of perfume and 50 parts by weight of dye solution were added.

This mixture was tested on subjects as in Example 1.

Result: "Creamy" feeling when rubbed in, pleasantly "grippy", "velvety" feeling after drying, no damage or impairments.

Example 4

A solution of 200 parts by weight of lanolin alcohol, 100 parts by weight of dexpanthenol, 200 parts by weight of Paraffinum perliquidum, 100 parts by weight of polyethylene glycol (4-E0) lauryl ether by stirring and heating to about 60 ° C. manufactured. After cooling, this solution was converted into a solution of 200 parts by weight of chlorhexidine digluconate, 14 280 parts by weight of water, 24 240 parts by weight of 2-propanol, 60 600 parts by weight of ethanol (96%, denatured with 1 % 2-butanone was added dropwise at room temperature, then 30 parts by weight of perfume and 50 parts by weight of dye solution were added. This mixture was tested with the same result as in the previous examples.

Example 5

A solution of 400 parts by weight of lanolin alcohol, 200 parts by weight of hexadecanol, 200 parts by weight of isopropyl myristate was prepared by stirring and heating to 60 ° C. After cooling, this solution was converted into a solution of 200 parts by weight of tetrabromo-p-cresol, 14 080 parts by weight of water, 36 360 parts by weight of 1-propanol and 48 480 parts by weight of 2-propanol at room temperature added dropwise with stirring and then 30 parts by weight of perfume and 50 parts by weight of dye solution were added.

This mixture was tested with the same result as in the previous examples.

Example 6

A solution of 700 parts by weight of lanolin alcohol, 300 parts by weight of glycerol triacetate, 500 parts by weight of dexpanthenol was prepared by stirring and heating to 60 ° C. This solution was added to a solution of 200 parts by weight of iodine-polyvinylpyRolidone, 38,950 parts by weight of water, 60,000 parts by weight of 1-propanol at room temperature and with stirring and then with 50 parts by weight of perfume transferred. The solution was a little milky.

As in the previous examples, it was tested with the same result. In game 7

A solution was prepared from 1000 parts by weight of lanolin alcohol, 200 parts by weight of dexpanthenol, 800 parts by weight of 2-ethylhexyl 2-ethylhexanoate and 300 parts by weight of isopropyl myristate by stirring and heating to 60 ° C. This solution was made into a solution of 200 parts by weight of mecetronium etilsulfate (INN). 70,000 parts by weight of 2-propanol and 27,720 parts by weight of water were added with stirring. Then 30 parts by weight of dye solution and 50 parts by weight of perfume were added. The solution was milky-cloudy.

As in the previous examples, it was tested with the same result.

Example 8

A solution of 50 parts by weight of lanolin alcohol, 100 parts by weight of 1-tetradecanol, 200 parts by weight of 2,2,4,4,6,8,8-heptamethylnonane and 200 parts by weight of 2-ethylhexyl -2-ethylhexanoate prepared by stirring and heating to about 40 ° C. After cooling, this solution was dissolved in a solution of 14 parts by weight of water, 84 840 parts by weight of ethanol (96%, denatured with 1% butanone), 50 parts by weight of pyrrolidone carboxylic acid and 100 parts by weight of Na. Salt of the pyrrolidone carboxylic acid was slowly added dropwise while stirring at room temperature, then 30 parts by weight of perfume and 50 parts by weight of dye solution were added: The mixture was then stirred for a further 30 minutes.

This mixture was tested on volunteers as in Example 1 with the same result. Examples 9-11

Melting solutions were prepared as follows:

For this purpose, the substances were heated with stirring until there was a melt.

Example 9 Example 10 Example 11 and 12 and 13 and 14

Glycerol - 200 parts by weight Lanolin alcohol 200 parts by weight 400 parts by weight 500 parts by weight Tetradecanol 400 parts by weight

While still warm, these solutions were slowly added to the following alcoholic solutions with stirring.

Example 9 Example 10 Example 11

n-propanol 25,000 parts by weight 25,000 parts by weight 25,000 parts by weight

2-propanol 40,000 parts by weight 40,000 parts by weight 40,000 parts by weight

Water 34400 parts by weight 34400 parts by weight 35500 parts by weight

Example 12 Example 13 Example 14

Ethanol 65000 parts by weight 65000 parts by weight 65000 parts by weight Water 34400 parts by weight 34400 parts by weight 34500 parts by weight

The mixture was then stirred at room temperature for a further 30 minutes. These mixtures were tested on subjects as in Example 1 with the same result.

Claims

claims

Alcoholic hand disinfectant, characterized in that it contains wool wax alcohols and / or cholesterol (cholesterol).

Alcoholic hand disinfectant according to claim 1, characterized in that it contains ethanol, 1-propanol and / or 2-propanol or mixtures thereof as alcohol.

Alcoholic hand disinfectant according to claim 1, characterized in that it contains 50 to 90 wt .-% alcohol, in particular 55 to 85 wt .-% alcohol, each based on the total agent.

Alcoholic hand disinfectant according to claim 1, characterized in that it contains 0.001 to 1 wt .-% wool wax alcohols and / or cholesterol, each based on the total agent.

Alcoholic hand disinfectant according to claim 1, characterized in that it contains more than 55 wt .-% alcohol and 0.001 to 1 wt .-%, preferably 0.01 to 0.3 wt .-% wool wax alcohols and / or cholesterol, each based on the entire mean.

^" Alcoholic hand disinfectant according to claim 1, characterized in that it contains one or more additional active ingredients, in particular remanent active ingredients.

7. Alcoholic hand disinfectant according to claim 6, characterized in that additional active ingredients come from the following groups: quaternary ammonium compounds, guanidinium compounds, phenols, per compounds, organic acids.

8. Alcoholic hand disinfectant according to claim 1, characterized in that it contains one or more other skin care substances in addition to wool wax alcohols and / or cholesterol.

9. Alcoholic hand disinfectant according to claim 1, characterized by the following composition:

Percent by weight

Alcohols (active ingredient) 90 - 50 but especially 85 - 55

Wool wax alcohols 0.001 - 1

Retentive substances 0 - 2 other skin care substances 0 - 2

Excipients 0 - 0.5

Water 10-50, especially 15-45

10. Alcoholic hand disinfectant according to claim 1, characterized by the following composition:

Percent by weight

Ethanol 80

Wool wax alcohols 0.05

Heptamethylnonane, in particular 2,2,4,4,6,8,8-heptamethylnonane 0.2

2-ethylhexyl-2-ethylhexanoate 0.2

Pyrrolidone carboxylic acid 0.05

Pyrrolidone carboxylic acid Na salt 0.1

Tetradecanol 0.1

2-butanone 0.08

Water ad 100

11. Use of wool wax alcohols and / or

Cholesterol as skin care substances in alcoholic hand disinfectants.