WO1994029351A3 - Antibodies - Google Patents

Antibodies Download PDF

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Publication number
WO1994029351A3
WO1994029351A3 PCT/GB1994/001290 GB9401290W WO9429351A3 WO 1994029351 A3 WO1994029351 A3 WO 1994029351A3 GB 9401290 W GB9401290 W GB 9401290W WO 9429351 A3 WO9429351 A3 WO 9429351A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibodies
provides
modulating
diagnosis
therapy
Prior art date
Application number
PCT/GB1994/001290
Other languages
French (fr)
Other versions
WO1994029351A2 (en
Inventor
Susan Adrienne Morgan
John Spencer Emtage
Mark William Bodmer
Diljeet Singh Athwal
Original Assignee
Celltech Ltd
Susan Adrienne Morgan
John Spencer Emtage
Mark William Bodmer
Diljeet Singh Athwal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939312415A external-priority patent/GB9312415D0/en
Priority claimed from GB9401597A external-priority patent/GB9401597D0/en
Priority claimed from GB9402499A external-priority patent/GB9402499D0/en
Priority claimed from GB9406244A external-priority patent/GB9406244D0/en
Application filed by Celltech Ltd, Susan Adrienne Morgan, John Spencer Emtage, Mark William Bodmer, Diljeet Singh Athwal filed Critical Celltech Ltd
Priority to EP94917750A priority Critical patent/EP0714409A1/en
Priority to AU69341/94A priority patent/AU691811B2/en
Priority to JP7501518A priority patent/JPH08511420A/en
Publication of WO1994029351A2 publication Critical patent/WO1994029351A2/en
Publication of WO1994029351A3 publication Critical patent/WO1994029351A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Abstract

The invention provides antibodies with altered ability to fix complement. The invention further relates to pharmaceutical, therapeutic and diagnostic compositions containing said antibodies and to methods of therapy and diagnosis using said antibodies. The invention additionally provides a method of modulating the function of cell surface associated antigens using said antibodies. Also provided are processes for preparing said antibodies.
PCT/GB1994/001290 1993-06-16 1994-06-15 Antibodies WO1994029351A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP94917750A EP0714409A1 (en) 1993-06-16 1994-06-15 Antibodies
AU69341/94A AU691811B2 (en) 1993-06-16 1994-06-15 Antibodies
JP7501518A JPH08511420A (en) 1993-06-16 1994-06-15 Body

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB9312415.4 1993-06-16
GB939312415A GB9312415D0 (en) 1993-06-16 1993-06-16 Altered antibodies
GB9401597A GB9401597D0 (en) 1994-01-27 1994-01-27 Altered antibodies
GB9401597.1 1994-01-27
GB9402499.9 1994-02-09
GB9402499A GB9402499D0 (en) 1994-02-09 1994-02-09 Altered abtibodies
GB9406244.5 1994-03-29
GB9406244A GB9406244D0 (en) 1994-03-29 1994-03-29 Altered antibodies

Publications (2)

Publication Number Publication Date
WO1994029351A2 WO1994029351A2 (en) 1994-12-22
WO1994029351A3 true WO1994029351A3 (en) 1994-12-22

Family

ID=27451034

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1994/001290 WO1994029351A2 (en) 1993-06-16 1994-06-15 Antibodies

Country Status (5)

Country Link
EP (1) EP0714409A1 (en)
JP (1) JPH08511420A (en)
AU (1) AU691811B2 (en)
CA (1) CA2163345A1 (en)
WO (1) WO1994029351A2 (en)

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