WO1994028144A1 - Cyclic gmp-binding, cyclic gmp-specific phosphodiesterase materials and methods - Google Patents
Cyclic gmp-binding, cyclic gmp-specific phosphodiesterase materials and methods Download PDFInfo
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- WO1994028144A1 WO1994028144A1 PCT/US1994/006066 US9406066W WO9428144A1 WO 1994028144 A1 WO1994028144 A1 WO 1994028144A1 US 9406066 W US9406066 W US 9406066W WO 9428144 A1 WO9428144 A1 WO 9428144A1
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- pde
- cgb
- leu
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Lubricants (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Saccharide Compounds (AREA)
Abstract
Description
Claims
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP50101295A JP4150070B2 (en) | 1993-05-27 | 1994-05-27 | Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materials and methods |
AT94919288T ATE199569T1 (en) | 1993-05-27 | 1994-05-27 | CYCLIC GMP BINDING CYCLIC GMP SPECIFIC PHOSPHODIESTERASE MATERIALS AND METHODS. |
CA002141060A CA2141060C (en) | 1993-05-27 | 1994-05-27 | Cyclic gmp-binding, cyclic gmp-specific phosphodiesterase materials and methods |
DE69426804A DE69426804D1 (en) | 1993-05-27 | 1994-05-27 | CYCLIC GMP BINDING CYCLIC GMP SPECIFIC PHOSPHODIESTERASE MATERIALS AND METHOD. |
DE69426804T DE69426804T4 (en) | 1993-05-27 | 1994-05-27 | CYCLIC GMP BINDING CYCLIC GMP SPECIFIC PHOSPHODIESTERASE MATERIALS AND METHOD. |
EP94919288A EP0652960B9 (en) | 1993-05-27 | 1994-05-27 | Cyclic gmp-binding, cyclic gmp-specific phosphodiesterase materials and methods |
DK94919288T DK0652960T3 (en) | 1993-05-27 | 1994-05-27 | Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materials and methods |
DK00112074T DK1038963T3 (en) | 1993-05-27 | 1994-05-27 | Cyclic GMP binding, cyclic GMP-specific phosphodiesterase materials and methods |
HK98114207A HK1013427A1 (en) | 1993-05-27 | 1998-12-21 | Cyclic gmp-binding, cyclic gmp-specific phosphodiesterase materials and methods |
GR20010400462T GR3035616T3 (en) | 1993-05-27 | 2001-03-21 | Cyclic gmp-binding, cyclic gmp-specific phosphodiesterase materials and methods. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6805193A | 1993-05-27 | 1993-05-27 | |
US08/068,051 | 1993-05-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1994028144A1 true WO1994028144A1 (en) | 1994-12-08 |
Family
ID=22080121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1994/006066 WO1994028144A1 (en) | 1993-05-27 | 1994-05-27 | Cyclic gmp-binding, cyclic gmp-specific phosphodiesterase materials and methods |
Country Status (13)
Country | Link |
---|---|
US (7) | US5702936A (en) |
EP (2) | EP0652960B9 (en) |
JP (3) | JP4150070B2 (en) |
AT (2) | ATE438723T1 (en) |
CA (3) | CA2141060C (en) |
DE (3) | DE69426804T4 (en) |
DK (2) | DK0652960T3 (en) |
ES (2) | ES2156898T3 (en) |
GR (1) | GR3035616T3 (en) |
HK (1) | HK1013427A1 (en) |
LV (1) | LV12814B (en) |
PT (2) | PT1038963E (en) |
WO (1) | WO1994028144A1 (en) |
Cited By (4)
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US5858694A (en) * | 1997-05-30 | 1999-01-12 | Cell Pathways, Inc. | Method for identifying compounds for inhibition of cancerous lesions |
WO1999042596A2 (en) * | 1998-02-23 | 1999-08-26 | Icos Corporation | Phosphodiesterase 10 |
WO2000040733A1 (en) * | 1999-01-07 | 2000-07-13 | Incyte Pharmaceuticals, Inc. | Human cyclic nucleotide pdes |
EP1414841A1 (en) * | 2001-07-10 | 2004-05-06 | Oligos Etc. Inc. | Oligonucleotide-containing pharmacological compositions and their use |
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US20060222647A1 (en) * | 1993-05-27 | 2006-10-05 | Beavo Joseph A | Methods and compositions for modulating the activity of PDE5 |
WO2000005383A1 (en) * | 1998-07-21 | 2000-02-03 | Takeda Chemical Industries, Ltd. | Novel protein and its dna |
JP2002531826A (en) * | 1998-11-25 | 2002-09-24 | セル パスウェイズ インコーポレイテッド | Neoplasia diagnostics |
US6875575B1 (en) | 1998-11-25 | 2005-04-05 | Osi Pharmaceuticals, Inc. | Diagnostic methods for neoplasia |
US6451807B1 (en) | 1999-04-30 | 2002-09-17 | Lilly Icos, Llc. | Methods of treating sexual dysfunction in an individual suffering from a retinal disease, class 1 congestive heart failure, or myocardial infarction using a PDE5 inhibitor |
US7098015B2 (en) * | 1999-06-11 | 2006-08-29 | Millennium Pharmaceuticals, Inc. | 27875, 22025, 27420, 17906, 16319, 55092 and 10218 molecules and uses therefor |
US6146876A (en) * | 1999-06-11 | 2000-11-14 | Millennium Pharmaceuticals, Inc. | 22025, a novel human cyclic nucleotide phosphodiesterase |
GB9922125D0 (en) | 1999-09-17 | 1999-11-17 | Pfizer Ltd | Phosphodiesterase enzymes |
CN1297049A (en) * | 1999-11-23 | 2001-05-30 | 上海博容基因开发有限公司 | Polypeptide-human cyclophosphate guanine suppressed phosphodiesterase 17 and polynucleotide for coding said polypeptide |
EP1278522B1 (en) | 2000-04-19 | 2006-10-25 | Lilly Icos LLC | Pde-v inhibitors for treatment of parkinson's disease |
GB0016009D0 (en) * | 2000-06-29 | 2000-08-23 | Pfizer Ltd | Target |
US6794192B2 (en) | 2000-06-29 | 2004-09-21 | Pfizer Inc. | Target |
US6846813B2 (en) * | 2000-06-30 | 2005-01-25 | Pharmacia & Upjohn Company | Compounds to treat alzheimer's disease |
US20030096864A1 (en) * | 2000-06-30 | 2003-05-22 | Fang Lawrence Y. | Compounds to treat alzheimer's disease |
WO2002022649A2 (en) * | 2000-09-14 | 2002-03-21 | Mount Sinai School Of Medicine | Screening methods to identify g-proteins and other compounds which modulate phosphodiesterase (pde) activity |
US7803982B2 (en) | 2001-04-20 | 2010-09-28 | The Mount Sinai School Of Medicine Of New York University | T1R3 transgenic animals, cells and related methods |
MXPA03009580A (en) * | 2001-04-20 | 2004-12-06 | Sinai School Medicine | T1r3 a novel taste receptor. |
US20070213407A1 (en) * | 2001-06-29 | 2007-09-13 | Elan Pharmaceuticals And Pharmacia & Upjohn Company Llc | Compounds to treat Alzheimer's disease |
US20050202549A1 (en) * | 2001-11-02 | 2005-09-15 | Pfizer Inc | Crystal structure |
GB0126417D0 (en) * | 2001-11-02 | 2002-01-02 | Pfizer Ltd | Crystal structure |
US7304128B2 (en) * | 2002-06-04 | 2007-12-04 | E.I. Du Pont De Nemours And Company | Carbon nanotube binding peptides |
WO2004097010A1 (en) * | 2003-05-01 | 2004-11-11 | Pfizer Limited | Crystal of pde5, its crystal structure and its use in drug design |
JP2010004758A (en) * | 2008-06-24 | 2010-01-14 | Probex Inc | Cyclic gmp detection method |
US8841104B2 (en) | 2010-04-21 | 2014-09-23 | Nanomr, Inc. | Methods for isolating a target analyte from a heterogeneous sample |
US9476812B2 (en) | 2010-04-21 | 2016-10-25 | Dna Electronics, Inc. | Methods for isolating a target analyte from a heterogeneous sample |
US20110262989A1 (en) | 2010-04-21 | 2011-10-27 | Nanomr, Inc. | Isolating a target analyte from a body fluid |
US9551704B2 (en) | 2012-12-19 | 2017-01-24 | Dna Electronics, Inc. | Target detection |
US10000557B2 (en) | 2012-12-19 | 2018-06-19 | Dnae Group Holdings Limited | Methods for raising antibodies |
US9995742B2 (en) | 2012-12-19 | 2018-06-12 | Dnae Group Holdings Limited | Sample entry |
US9599610B2 (en) | 2012-12-19 | 2017-03-21 | Dnae Group Holdings Limited | Target capture system |
US9434940B2 (en) | 2012-12-19 | 2016-09-06 | Dna Electronics, Inc. | Methods for universal target capture |
US9804069B2 (en) | 2012-12-19 | 2017-10-31 | Dnae Group Holdings Limited | Methods for degrading nucleic acid |
KR101550217B1 (en) * | 2014-03-26 | 2015-09-04 | 전남대학교산학협력단 | Recombinant vector for foreign gene expression without biological circuit interference of host cell and uses thereof |
JP6885595B2 (en) * | 2015-12-04 | 2021-06-16 | 国立大学法人 東京大学 | Ligand Fluorescence Sensor Protein and Its Use |
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DE1290210B (en) * | 1962-12-04 | 1969-03-06 | Siemens Ag | Device for machine laying and connecting switching wires |
US4129349A (en) * | 1975-11-10 | 1978-12-12 | Bell Telephone Laboratories, Incorporated | Quick-connect breadboarding system |
JPH0797015B2 (en) * | 1988-10-28 | 1995-10-18 | 株式会社ピーエフユー | Position correction method of SMD by image processing |
US5098890A (en) * | 1988-11-07 | 1992-03-24 | Temple University-Of The Commonwealth System Of Higher Education | Antisence oligonucleotides to c-myb proto-oncogene and uses thereof |
JPH038400A (en) * | 1989-06-06 | 1991-01-16 | Sharp Corp | Positional correction of printed substrate |
US4958013A (en) * | 1989-06-06 | 1990-09-18 | Northwestern University | Cholesteryl modified oligonucleotides |
US5015637A (en) * | 1990-05-25 | 1991-05-14 | Hoechst-Roussel Pharmaceutical Inc. | Pyrido[3,4-b]pyrrolo[1,2-e][1,4,5]oxadiazepines |
DE69233214T2 (en) * | 1991-04-19 | 2004-07-01 | The Board Of Regents Of The University Of Washington, Seattle | DNA ENCODING MAMMAL PHOSPHODIESTERASES |
AU2580892A (en) * | 1991-09-05 | 1993-04-05 | Isis Pharmaceuticals, Inc. | Determination of oligonucleotides for therapeutics, diagnostics and research reagents |
US6403302B1 (en) * | 1992-09-17 | 2002-06-11 | California Institute Of Technology | Methods and compositions for triple helix formation |
-
1994
- 1994-05-27 DE DE69426804T patent/DE69426804T4/en not_active Expired - Lifetime
- 1994-05-27 EP EP94919288A patent/EP0652960B9/en not_active Expired - Lifetime
- 1994-05-27 DK DK94919288T patent/DK0652960T3/en active
- 1994-05-27 ES ES94919288T patent/ES2156898T3/en not_active Expired - Lifetime
- 1994-05-27 EP EP00112074A patent/EP1038963B1/en not_active Expired - Lifetime
- 1994-05-27 JP JP50101295A patent/JP4150070B2/en not_active Expired - Fee Related
- 1994-05-27 DE DE69435227T patent/DE69435227D1/en not_active Expired - Lifetime
- 1994-05-27 PT PT00112074T patent/PT1038963E/en unknown
- 1994-05-27 DK DK00112074T patent/DK1038963T3/en active
- 1994-05-27 ES ES00112074T patent/ES2333691T3/en not_active Expired - Lifetime
- 1994-05-27 AT AT00112074T patent/ATE438723T1/en not_active IP Right Cessation
- 1994-05-27 PT PT94919288T patent/PT652960E/en unknown
- 1994-05-27 DE DE69426804A patent/DE69426804D1/en not_active Expired - Lifetime
- 1994-05-27 US US08/250,847 patent/US5702936A/en not_active Expired - Lifetime
- 1994-05-27 WO PCT/US1994/006066 patent/WO1994028144A1/en active IP Right Grant
- 1994-05-27 CA CA002141060A patent/CA2141060C/en not_active Expired - Fee Related
- 1994-05-27 CA CA2363537A patent/CA2363537C/en not_active Expired - Fee Related
- 1994-05-27 AT AT94919288T patent/ATE199569T1/en not_active IP Right Cessation
- 1994-05-27 CA CA2698716A patent/CA2698716A1/en not_active Abandoned
-
1995
- 1995-06-05 US US08/464,410 patent/US6037119A/en not_active Expired - Lifetime
- 1995-06-05 US US08/463,949 patent/US5955583A/en not_active Expired - Lifetime
- 1995-06-07 US US08/480,547 patent/US5652131A/en not_active Expired - Lifetime
-
1998
- 1998-12-21 HK HK98114207A patent/HK1013427A1/en not_active IP Right Cessation
-
2001
- 2001-03-21 GR GR20010400462T patent/GR3035616T3/en unknown
- 2001-12-12 LV LVP-01-167A patent/LV12814B/en unknown
-
2002
- 2002-04-03 US US10/115,515 patent/US20030054992A1/en not_active Abandoned
-
2003
- 2003-01-28 US US10/353,575 patent/US20050196833A1/en not_active Abandoned
-
2005
- 2005-05-24 JP JP2005150760A patent/JP4450767B2/en not_active Expired - Fee Related
- 2005-12-21 US US11/315,036 patent/US20060216809A1/en not_active Abandoned
-
2009
- 2009-11-25 JP JP2009267135A patent/JP2010042035A/en active Pending
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COLLINS ET AL.: "The human Beta-Subunit of Rod Photoreceptor cGMP Phosphodiesterase: Complete Retinal cDNA Sequence and Evidence for Expression in Brain", GENOMICS, vol. 13, no. 3, July 1992 (1992-07-01), pages 698 - 704 * |
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THOMAS ET AL.: "Characterization of a Purified Bovine Lung cGMP-binding cGMP Phosphodiesterase", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 265, no. 25, 5 September 1990 (1990-09-05), BALTIMORE, MD US, pages 14964 - 14970 * |
THOMAS ETAL.: "Substrate- and Kinase-directed regulation of Phosphorylation of a cGMP-binding Phosphodiesterase by cGMP.", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 265, no. 25, 5 September 1990 (1990-09-05), BALTIMORE US, pages 14971 - 14978 * |
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WO1999042596A2 (en) * | 1998-02-23 | 1999-08-26 | Icos Corporation | Phosphodiesterase 10 |
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WO2000040733A1 (en) * | 1999-01-07 | 2000-07-13 | Incyte Pharmaceuticals, Inc. | Human cyclic nucleotide pdes |
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