WO1994025836A1 - Calibration apparatus for laser ablative systems - Google Patents
Calibration apparatus for laser ablative systems Download PDFInfo
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- WO1994025836A1 WO1994025836A1 PCT/US1993/004110 US9304110W WO9425836A1 WO 1994025836 A1 WO1994025836 A1 WO 1994025836A1 US 9304110 W US9304110 W US 9304110W WO 9425836 A1 WO9425836 A1 WO 9425836A1
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- Prior art keywords
- laser beam
- photoreactive
- properties
- intensity profile
- radiation
- Prior art date
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J1/00—Photometry, e.g. photographic exposure meter
- G01J1/48—Photometry, e.g. photographic exposure meter using chemical effects
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/02—Positioning or observing the workpiece, e.g. with respect to the point of impact; Aligning, aiming or focusing the laser beam
- B23K26/03—Observing, e.g. monitoring, the workpiece
- B23K26/032—Observing, e.g. monitoring, the workpiece using optical means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/02—Positioning or observing the workpiece, e.g. with respect to the point of impact; Aligning, aiming or focusing the laser beam
- B23K26/06—Shaping the laser beam, e.g. by masks or multi-focusing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/02—Positioning or observing the workpiece, e.g. with respect to the point of impact; Aligning, aiming or focusing the laser beam
- B23K26/06—Shaping the laser beam, e.g. by masks or multi-focusing
- B23K26/064—Shaping the laser beam, e.g. by masks or multi-focusing by means of optical elements, e.g. lenses, mirrors or prisms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/02—Positioning or observing the workpiece, e.g. with respect to the point of impact; Aligning, aiming or focusing the laser beam
- B23K26/06—Shaping the laser beam, e.g. by masks or multi-focusing
- B23K26/064—Shaping the laser beam, e.g. by masks or multi-focusing by means of optical elements, e.g. lenses, mirrors or prisms
- B23K26/0648—Shaping the laser beam, e.g. by masks or multi-focusing by means of optical elements, e.g. lenses, mirrors or prisms comprising lenses
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/70—Auxiliary operations or equipment
- B23K26/702—Auxiliary equipment
- B23K26/705—Beam measuring device
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00855—Calibration of the laser system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00861—Methods or devices for eye surgery using laser adapted for treatment at a particular location
- A61F2009/00872—Cornea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F9/00802—Methods or devices for eye surgery using laser for photoablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F9/00802—Methods or devices for eye surgery using laser for photoablation
- A61F9/00817—Beam shaping with masks
- A61F9/00819—Beam shaping with masks with photoablatable masks
Definitions
- the technical field of this invention is laser ablation of surfaces.
- the invention relates to systems and methods for measuring and recording the properties of laser ablation systems.
- Ablative laser radiation is also being studied for various other surgical purposes, including arthroscopic surgery, angioplasty, treatment of skin diseases and dentistry.
- ablative laser systems are becoming increasingly commonplace in non-surgical applications, such as the micromachining of electronic components and other industrial processes.
- the amount of energy required to ablate a desired amount of material from the target element is first calculated.
- the laser is then directed to supply an amount of energy slightly less than this calculated amount to allow for deviation in the predicted response of the element to the laser energy and for deviations in the ablation system.
- the steps of measuring a parameter and applying energy are repeated until the optical element is reshaped within predetermined tolerance limits.
- One drawback with this approach is the additional time necessary to complete the iterative process which prolongs the operation and increases the risk of misalignment occurring.
- Another disadvantage with feedback control systems based on reflective optical measurements is the lack of a physical record of the ablative properties of the laser and beamshaping/focusing system. Such a record can provide a baseline for comparing the operation of the ablation system from one usage to another and for correcting errors before the system is put into use on a patient. Further, should a problem arise after a procedure is completed, a physical record of the output of the laser and beamshaping/focusing elements would be of use in determining whether the proper protocol was followed by the clinician.
- a calibration apparatus for measuring the properties of a laser beam.
- the apparatus includes a photoreactive element having a composition which reacts with laser radiation in a manner dependent upon the intensity or intensity profile of the laser beam and an alignment means for disposing the photoreactive element in the path of a laser beam, such that the beam can be activated to impinge upon the photoreactive element and the properties of the beam are recorded by changes in the state of the photoreactive element.
- the photoreactive element is an erodable element formed from a erodable material having ablation characteristics similar to that of biological tissue, such that the calibration apparatus can be used to ensure that surgical laser apparatus is operating within desired parameters.
- the invention is particularly useful in connection with corneal surgical systems for performing photorefractive keratectomy where the surface of the cornea is reprofiled to correct vision disorders.
- a photoreactive element as a calibration apparatus, the parameters affecting such a corneal procedure (e.g., beam homogeneity, focusing and beam-shaping over time) can be assessed before the system is used to treat a patient's eye.
- the photoreactive element provides a physical record of the laser beam profile which can be examined prior to the procedure to either confirm proper operation of the laser apparatus or to permit modification of the operating parameters either manually or by automated feedback control.
- the photoreactive element can include an optical indicator which is either modified or ablated by laser radiation.
- this element can include an indicator substance, such as a pigment, dye or fluorescent material.
- the photoreactive element is eroded to create a calibration record, the amount of the optical indicator remaining in specific portions of the element will vary depending upon the intensity and duration of exposure to the ablative radiation. These changes in the optical indicator can be detected by a simple photodetector or camera system.
- optical indicator can be readily chosen for optical properties within the visible spectrum.
- optical properties rather than the ultraviolet radiation which is generated directly by the laser ablation system
- less expensive and simpler cameras such as simple CCD cameras, can be used to record and/or analyze the calibration records, as well as readily permit visual observation of the calibration record, itself.
- a calibration system for monitoring calibration records including an illumination source and a photodetector, which detects the changes in the optical indicator following exposure to the ablative laser radiation. Signals from the detector can then be transmitted to a computer or the like for storage as digital data or can be transmitted to an analyzing device to generate control or feedback signals.
- the photoreactive element can be a radiation-absorbing element which does not lose its physical shape upon exposure to ablative radiation but rather has optical properties which are altered.
- radiation-absorbing elements can consist of materials which are bleached, darkened or which fluoresce upon exposure to laser radiation. Again, these optical properties can be chosen to permit inspection and monitoring by photodetectors operating within the visible spectrum, and the records can be stored as digital data or analyzed to provide feedback and/or control signals.
- FIG. 1 is a schematic illustration of a calibration apparatus for use in calibrating a laser ablation system according to the invention
- FIG. 2 is a schematic illustration of another calibration apparatus according to the invention.
- FIG. 3 is a more detailed schematic illustration of a beam- shaping assembly and calibration apparatus for use in the system of FIG.
- FIGS. 4A and 4B illustrate one embodiment of a calibration record before and after exposure to ablative radiation, respectively, in a calibration system according to the invention
- FIG. 5 is a schematic illustration of how a calibration record can be read optically
- FIG. 6 is a schematic illustration of a monitoring system for reading calibration records according to the invention.
- FIG. 7 is a schematic illustration of another embodiment of a calibration apparatus for use in a laser ablation system according to the invention.
- FIG. 8 is a block diagram of a laser ablation system incorporating the calibration apparatus of the present invention for feedback control.
- a laser ablation system 10 with a calibration apparatus 16 is shown.
- system 10 includes laser 12, and, optionally, a beam-shaping assembly 14 for modifying the shape and/or size of the ablative radiation beam over time, as desired, to effect reprofiling of a surface.
- the calibration apparatus 16 can include a photoreactive element 18 and a mounting means 20, as shown.
- Each of the elements 12, 14 and 16 are preferably connected via an alignment element 21 onto an optical rail 22 or the like in order to maintain alignment during the calibration process.
- the calibration apparatus 16 can take various forms, including the two-layer, plastic block shown in FIG. 1.
- the layer 18 is preferably formed of a photoreactive material having a composition which reacts with laser radiation in a manner proportional to the intensity profile of the laser beam.
- This photoreactive element 18 can be mounted upon a non-reactive carrier or mounting element 20, as shown.
- This backing 20 can be optically transparent or reflective to assist in optical read-out of the calibration records.
- transparent backing materials include glass, quartz and optically-transparent plastics.
- the transparent backing should be capable of transmitting radiation throughout at least a portion of the spectrum from about 180 to about 1200 nanometers.
- the transparent backing be transmissive not only in the region of the ablative radiation but also in at least a portion of the spectrum from about 450 nanometers to about 900 nanometers to permit the use of visible light in displaying or measuring the calibration record.
- the transparent backing should be optically homogeneous, well characterized and stable over time.
- Reflective backing materials can be formed from similar materials with reflective metal coatings or the like. For reasons similar to those expressed above for transparent backings, a broadband reflector is preferable to permit the use of visible light for read-out purposes. In some applications, reflectance of the ablative radiation wavelength may not be necessary at all, so long as visible light can be reflected by the material following recording.
- a single layer structure can be employed with the photoreactive element serving to provide a record of the laser radiation, itself, so long as it has sufficient thickness and/or strength to ensure that structural integrity is maintained following irradiation.
- FIG. 2 An alternative calibration apparatus 16A is shown in FIG. 2 where the plastic block of FIG. 1 has been replaced with a tape apparatus 21 A, including mechanized tape transport reels 17 and 19 which serve to align the tape with the laser beam and transport the tape across the beam path, such that a "snapshot" can be taken of the beam profile, (e.g., a recording of the intensity profile effected by a series of ablative pulses during a time period, or frame, of predefined duration).
- the calibration apparatus 16A (shown in FIG. 2) can be constructed into two layers: a photoreactive layer 18A and a carrier tape layer 20 A.
- the tape can include a transparent or reflective, non- reactive material having photoreactive elements incorporated therein.
- the photoreactive element can be an erodable element, for example, a polymeric block or tape having a thickness of about 10 micrometers to about 100 micrometers, preferably from about 25 micrometers to about 75 micrometers, which is ablated by the laser radiation to create a physical record of the laser radiation.
- the erodable element can further included an optical indicator, which is lost during the ablation process, such that those regions of the calibration record which are ablated will be either less saturated in color or, otherwise, modified in terms of transparency or absorptivity.
- the optical indicator can be an indicator substance chosen from the group consisting of pigments, dyes and fluorescent substances.
- the photoreactive element can be a radiation-absorbing element, which does not lose its physical shape upon exposure to the ablative radiation but rather has optical properties which are altered.
- Such radiation-absorbing elements can consist of materials which are bleached, darkened or subject to fluorescence upon exposure to laser radiation.
- an erodable calibration record is a polymeric coating of polymethylmethacrylate (PMMA), polymethylstyrene, polycarbonate or mixtures thereof.
- PMMA polymethylmethacrylate
- suitable polycarbonate calibration records can be fabricated from LEXAN® resins, (commercially available from General Electric, Pittsfield, Massachusetts) or from CR-39® resins (PPG Industries, Pittsburgh, Pennsylvania).
- the erodable calibration record can have similar ablation characteristics to biological tissue, particularly when the laser ablation system is directed to use in reprofiling biological materials, such as the ocular cornea.
- the absorption coefficient of such erodable, polymeric calibration records can range from about 10-3 cm"* to about l ⁇ 6 cm'l.
- the polymeric record can be treated for colorimetric analysis by adding a dye or other colorant either during polymerization or via diffusion after polymerization. Diffusioned dye (assisted by heating or pressurization) can be advantageous because it permits the dye to be distributed in a non-linear fashion relative to the thickness of the record. In some applications, this non-linear distribution is preferred for read-out purposes.
- the beam- shaping assembly includes a first convex lens 24, an adjustable iris 26, and a concave lens 28. Together, these elements cooperate to produce an ablative radiation beam, which can be varied in cross-sectional area over time. By progressively opening the iris 26, an ablation pattern will be presented to the target surface in which the greatest ablative energy impinges upon a central region of the target and progressively decreases to the periphery.
- the calibration apparatus 16 A shown in FIG. 3, can be used to determine whether the laser beam and the beam-shaping assembly 14A are properly configured to affect the desired ablation profile. By disposing the calibration apparatus 16A within the beam path and then varying the opening of the aperture 26 in accordance with the planned procedure, an ablation record 30 will be created in the photoreactive element 18.
- FIGS. 4 A and 4B further illustrate this process schematically.
- the calibration apparatus can include a photoreactive (e.g., erodable) layer 18 and a carrier 20 (e.g., a transparent block of material or a transparent tape carrier).
- a photoreactive layer 18 e.g., erodable
- a carrier 20 e.g., a transparent block of material or a transparent tape carrier.
- the calibration apparatus in FIG. 4A Prior to exposure to ablative radiation, the calibration apparatus in FIG. 4A has a uniform and planar surface.
- a calibration record 30 has been created by the ablative action of the laser radiation upon the photoreactive element 18.
- FIG. 5 illustrates how this calibration record can be monitored or interpreted optically.
- calibration system 40 is shown for reading the calibration apparatus 16 and records 30 contained thereon.
- the system 40 includes a light source 36 emitting light which can be either spatially or temporally coherent or non-coherent and a detector 38 for measuring the intensity profile of the light transmitted through the calibration record.
- the detector 38 can further be coupled to a computer storage system 39 for digital storage of the calibration data and/or analysis thereof.
- FIG. 7 another embodiment of a laser ablation system employing a calibration apparatus is shown.
- a calibration record can be made simultaneously with the ablation procedure.
- the system includes a laser 12 beam-shaping assembly 14 and tape calibration apparatus 16A, which is disposed at an angle to the beam path.
- a beam-splitting mirror 13, which preferably is movable and adjustable, can be disposed within the path and diverts a portion of the ablative radiation beam to the calibration apparatus 16A. The remainder of the beam is transmitted via mirror 15 and imaging lens 11 to the target, e.g., the cornea of an eye 50.
- the beam-shaping mirror 13 can be chosen to reflect only a small portion of the ablative radiation, and the photoreactive element 18 of the calibration apparatus 16A can be chosen from materials which are very sensitive to the ablative radiation, such that only a small fraction of the total beam energy is necessary in order to create a calibration record.
- an overall ablation system 10A employing a calibration apparatus as part of a feedback control mechanism.
- the system 10 A includes a laser, generating a beam of ablative radiation for reprofiling a surface 50, such as the cornea of an eye.
- the system further includes a beam-shaping assembly 14, a calibration apparatus 16, an analyzer 42 and a controller 44.
- the laser radiation beam, itself, or the output of the beam-shaping assembly 14 can be monitored by the calibration apparatus prior to commencement of the corneal reshaping procedure. If the ablation apparatus determines that the beam shape is correct, the calibration apparatus can be removed from the optical beam path, and the procedure begins.
- the calibration apparatus creates a record which the analyzer 42 determines to be unsatisfactory, a feedback control signal is transmitted via controller 44 to the laser or beam shaper in order to effect correction of one or more parameters. The procedure is then repeated until the calibration apparatus indicates that the desired profile will be achieved.
Abstract
A calibration apparatus is disclosed for measuring the properties of a laser beam. The apparatus includes a photoreactive element having a composition which reacts with laser radiation in a manner proportional to the intensity or intensity profile of the laser beam and an alignment means for disposing the photoreactive element in the path of a laser beam, such that the beam can be activated to impinge upon the photoreactive element, and the properties of the beam are recorded by changes in the state of the calibration element.
Description
CALIBRATION APPARATUS FOR LASER ABLATIVE SYSTEMS
Background of the Invention
The technical field of this invention is laser ablation of surfaces. In particular, the invention relates to systems and methods for measuring and recording the properties of laser ablation systems.
It is known to employ lasers to erode surfaces of workpieces. Recently, lasers have also been used as surgical devices. The ability of certain lasers to reprofile biological materials has created major new opportunities for corrective and/or cosmetic operations. For example, a variety of lasers emitting high intensity, rapidly pulsed radiation are currently being investigated for use in corneal reprofiling procedures to change the shape of the cornea and, thereby, correct refractive vision disorders, such as myopia (nearsightedness), hyperopia (farsightedness) and astigmatisms (deviations from spherical symmetry).
Ablative laser radiation is also being studied for various other surgical purposes, including arthroscopic surgery, angioplasty, treatment of skin diseases and dentistry. Moreover, ablative laser systems are becoming increasingly commonplace in non-surgical applications, such as the micromachining of electronic components and other industrial processes.
In most laser ablative procedures, precise control of the laser beam parameters, including the initial spatial beam profile, and any homogenizing, focusing or beamshaping operations are critical to success in reprofiling a target surface. This is especially true in biological reprofiling procedures, such as photorefractive keratectomy (PRK) where layers of corneal tissue only a few microns in thickness are to be ablated.
Various methods for monitoring laser ablative procedures have been proposed. For example, a feedback control system for PRK operations is described in the U.S. Pat. No. 4,941,093 to Marshall et al. In this system, a keratometer forms part of laser ablation apparatus and continually measures the curvature of the cornea to compare actually observed conditions with predicted values. The amount of energy required to ablate a desired amount of material from the target element is first calculated. The laser is then directed to supply an amount of energy slightly less than this calculated amount to allow for deviation in the predicted response of the element to the laser energy and for deviations in the ablation system. The steps of measuring a parameter and applying energy are repeated until the optical element is reshaped within predetermined tolerance limits. One drawback with this approach is the additional time necessary to complete the iterative process which prolongs the operation and increases the risk of misalignment occurring.
Another disadvantage with feedback control systems based on reflective optical measurements is the lack of a physical record of the ablative properties of the laser and beamshaping/focusing system. Such a record can provide a baseline for comparing the operation of the ablation system from one usage to another and for correcting errors before the system is put into use on a patient. Further, should a problem arise after a procedure is completed, a physical record of the output of the laser and beamshaping/focusing elements would be of use in determining whether the proper protocol was followed by the clinician.
Thus, it is an object of the present invention to provide an apparatus and method for analytically determining the initial conditions of a laser ablation system and for creating a physical record of the ablative properties of the ablation system.
It is also an object of the present invention to incorporate analysis and feedback apparatus and methods to control the laser ablation
system based on the physical properties of a physical record.
Summary of the Invention
A calibration apparatus is disclosed for measuring the properties of a laser beam. The apparatus includes a photoreactive element having a composition which reacts with laser radiation in a manner dependent upon the intensity or intensity profile of the laser beam and an alignment means for disposing the photoreactive element in the path of a laser beam, such that the beam can be activated to impinge upon the photoreactive element and the properties of the beam are recorded by changes in the state of the photoreactive element.
In one embodiment, the photoreactive element is an erodable element formed from a erodable material having ablation characteristics similar to that of biological tissue, such that the calibration apparatus can be used to ensure that surgical laser apparatus is operating within desired parameters.
The invention is particularly useful in connection with corneal surgical systems for performing photorefractive keratectomy where the surface of the cornea is reprofiled to correct vision disorders. By employing a photoreactive element as a calibration apparatus, the parameters affecting such a corneal procedure (e.g., beam homogeneity, focusing and beam-shaping over time) can be assessed before the system is used to treat a patient's eye. Moreover, the photoreactive element provides a physical record of the laser beam profile which can be examined prior to the procedure to either confirm proper operation of the laser apparatus or to permit modification of the operating parameters either manually or by automated feedback control.
In a further aspect of the invention, the photoreactive element can include an optical indicator which is either modified or ablated by laser radiation. For example, when an erodable element is
employed, this element can include an indicator substance, such as a pigment, dye or fluorescent material. As the photoreactive element is eroded to create a calibration record, the amount of the optical indicator remaining in specific portions of the element will vary depending upon the intensity and duration of exposure to the ablative radiation. These changes in the optical indicator can be detected by a simple photodetector or camera system.
A principal advantage in using an optical indicator is that such indicators can be readily chosen for optical properties within the visible spectrum. By measuring changes in visible, optical properties (rather than the ultraviolet radiation which is generated directly by the laser ablation system), less expensive and simpler cameras, such as simple CCD cameras, can be used to record and/or analyze the calibration records, as well as readily permit visual observation of the calibration record, itself.
In yet a further aspect of the invention, a calibration system for monitoring calibration records is disclosed, including an illumination source and a photodetector, which detects the changes in the optical indicator following exposure to the ablative laser radiation. Signals from the detector can then be transmitted to a computer or the like for storage as digital data or can be transmitted to an analyzing device to generate control or feedback signals.
In another embodiment of the invention, the photoreactive element can be a radiation-absorbing element which does not lose its physical shape upon exposure to ablative radiation but rather has optical properties which are altered. Such radiation-absorbing elements can consist of materials which are bleached, darkened or which fluoresce upon exposure to laser radiation. Again, these optical properties can be chosen to permit inspection and monitoring by photodetectors operating within the visible spectrum, and the records can be stored as digital data
or analyzed to provide feedback and/or control signals.
The invention will next be described in connection with certain preferred embodiments; however, it should be clear that various additions, subtractions and modifications can be made without departing from the spirit or scope of the claims.
Brief Description of the Drawings
FIG. 1 is a schematic illustration of a calibration apparatus for use in calibrating a laser ablation system according to the invention;
FIG. 2 is a schematic illustration of another calibration apparatus according to the invention;
FIG. 3 is a more detailed schematic illustration of a beam- shaping assembly and calibration apparatus for use in the system of FIG.
2;
FIGS. 4A and 4B illustrate one embodiment of a calibration record before and after exposure to ablative radiation, respectively, in a calibration system according to the invention;
FIG. 5 is a schematic illustration of how a calibration record can be read optically;
FIG. 6 is a schematic illustration of a monitoring system for reading calibration records according to the invention;
FIG. 7 is a schematic illustration of another embodiment of a calibration apparatus for use in a laser ablation system according to the invention; and
FIG. 8 is a block diagram of a laser ablation system
incorporating the calibration apparatus of the present invention for feedback control.
Detailed Description
In FIG. 1, a laser ablation system 10 with a calibration apparatus 16 is shown. As shown, system 10 includes laser 12, and, optionally, a beam-shaping assembly 14 for modifying the shape and/or size of the ablative radiation beam over time, as desired, to effect reprofiling of a surface. The calibration apparatus 16 can include a photoreactive element 18 and a mounting means 20, as shown. Each of the elements 12, 14 and 16 are preferably connected via an alignment element 21 onto an optical rail 22 or the like in order to maintain alignment during the calibration process.
The calibration apparatus 16 can take various forms, including the two-layer, plastic block shown in FIG. 1. The layer 18 is preferably formed of a photoreactive material having a composition which reacts with laser radiation in a manner proportional to the intensity profile of the laser beam. This photoreactive element 18 can be mounted upon a non-reactive carrier or mounting element 20, as shown. This backing 20 can be optically transparent or reflective to assist in optical read-out of the calibration records.
Examples of transparent backing materials include glass, quartz and optically-transparent plastics. Depending upon the laser undergoing calibration, the transparent backing should be capable of transmitting radiation throughout at least a portion of the spectrum from about 180 to about 1200 nanometers. For read-out purposes, it is preferable that the transparent backing be transmissive not only in the region of the ablative radiation but also in at least a portion of the spectrum from about 450 nanometers to about 900 nanometers to permit the use of visible light in displaying or measuring the calibration record.
In any event, the transparent backing should be optically homogeneous, well characterized and stable over time.
Reflective backing materials can be formed from similar materials with reflective metal coatings or the like. For reasons similar to those expressed above for transparent backings, a broadband reflector is preferable to permit the use of visible light for read-out purposes. In some applications, reflectance of the ablative radiation wavelength may not be necessary at all, so long as visible light can be reflected by the material following recording.
Alternatively, a single layer structure can be employed with the photoreactive element serving to provide a record of the laser radiation, itself, so long as it has sufficient thickness and/or strength to ensure that structural integrity is maintained following irradiation.
An alternative calibration apparatus 16A is shown in FIG. 2 where the plastic block of FIG. 1 has been replaced with a tape apparatus 21 A, including mechanized tape transport reels 17 and 19 which serve to align the tape with the laser beam and transport the tape across the beam path, such that a "snapshot" can be taken of the beam profile, (e.g., a recording of the intensity profile effected by a series of ablative pulses during a time period, or frame, of predefined duration). Again, the calibration apparatus 16A (shown in FIG. 2) can be constructed into two layers: a photoreactive layer 18A and a carrier tape layer 20 A. Alternatively, the tape can include a transparent or reflective, non- reactive material having photoreactive elements incorporated therein.
In one embodiment, the photoreactive element can be an erodable element, for example, a polymeric block or tape having a thickness of about 10 micrometers to about 100 micrometers, preferably from about 25 micrometers to about 75 micrometers, which is ablated by the laser radiation to create a physical record of the laser radiation. This
-o-
erodable element can further included an optical indicator, which is lost during the ablation process, such that those regions of the calibration record which are ablated will be either less saturated in color or, otherwise, modified in terms of transparency or absorptivity. The optical indicator can be an indicator substance chosen from the group consisting of pigments, dyes and fluorescent substances. Alternatively, the photoreactive element can be a radiation-absorbing element, which does not lose its physical shape upon exposure to the ablative radiation but rather has optical properties which are altered. Such radiation-absorbing elements can consist of materials which are bleached, darkened or subject to fluorescence upon exposure to laser radiation.
One preferred material for an erodable calibration record is a polymeric coating of polymethylmethacrylate (PMMA), polymethylstyrene, polycarbonate or mixtures thereof. For example, suitable polycarbonate calibration records can be fabricated from LEXAN® resins, (commercially available from General Electric, Pittsfield, Massachusetts) or from CR-39® resins (PPG Industries, Pittsburgh, Pennsylvania). Conveniently, the erodable calibration record can have similar ablation characteristics to biological tissue, particularly when the laser ablation system is directed to use in reprofiling biological materials, such as the ocular cornea. The absorption coefficient of such erodable, polymeric calibration records can range from about 10-3 cm"* to about lθ6 cm'l. The polymeric record can be treated for colorimetric analysis by adding a dye or other colorant either during polymerization or via diffusion after polymerization. Diffusioned dye (assisted by heating or pressurization) can be advantageous because it permits the dye to be distributed in a non-linear fashion relative to the thickness of the record. In some applications, this non-linear distribution is preferred for read-out purposes.
In FIG. 3, an embodiment of a beam-shaping assembly 14 suitable for use in the system 10 is shown in more detail in conjunction
with a tape-transport calibration apparatus 16 A. As shown, the beam- shaping assembly includes a first convex lens 24, an adjustable iris 26, and a concave lens 28. Together, these elements cooperate to produce an ablative radiation beam, which can be varied in cross-sectional area over time. By progressively opening the iris 26, an ablation pattern will be presented to the target surface in which the greatest ablative energy impinges upon a central region of the target and progressively decreases to the periphery. When such an ablation profile is applied to a convex surface, such as the cornea of an eye, the result is a reprofiling effect that serves to flatten the curvature of the surface. In this manner, myopia, a common vision disorder can be corrected by reprofiling the cornea. Thus, the calibration apparatus 16 A, shown in FIG. 3, can be used to determine whether the laser beam and the beam-shaping assembly 14A are properly configured to affect the desired ablation profile. By disposing the calibration apparatus 16A within the beam path and then varying the opening of the aperture 26 in accordance with the planned procedure, an ablation record 30 will be created in the photoreactive element 18.
FIGS. 4 A and 4B further illustrate this process schematically. As shown in FIG. 4A, the calibration apparatus can include a photoreactive (e.g., erodable) layer 18 and a carrier 20 (e.g., a transparent block of material or a transparent tape carrier). Prior to exposure to ablative radiation, the calibration apparatus in FIG. 4A has a uniform and planar surface. Following to exposure to laser radiation, as shown in FIG. 4B, a calibration record 30 has been created by the ablative action of the laser radiation upon the photoreactive element 18.
FIG. 5 illustrates how this calibration record can be monitored or interpreted optically. Once the calibration record has been created in the photoreactive element 18, it can be subjected to illuminating light 32. As the "read out" light passes through the calibration record, it is modified by the optical properties of the record,
itself, such that a modified light beam 34 smerges. As noted above, the optical properties which can be modified include, color, absorptivity, fluorescence and the like.
In FIG. 6, calibration system 40 is shown for reading the calibration apparatus 16 and records 30 contained thereon. As shown, the system 40 includes a light source 36 emitting light which can be either spatially or temporally coherent or non-coherent and a detector 38 for measuring the intensity profile of the light transmitted through the calibration record. The detector 38 can further be coupled to a computer storage system 39 for digital storage of the calibration data and/or analysis thereof.
In FIG. 7, another embodiment of a laser ablation system employing a calibration apparatus is shown. In the embodiment of FIG. 7, a calibration record can be made simultaneously with the ablation procedure. As shown, the system includes a laser 12 beam-shaping assembly 14 and tape calibration apparatus 16A, which is disposed at an angle to the beam path. A beam-splitting mirror 13, which preferably is movable and adjustable, can be disposed within the path and diverts a portion of the ablative radiation beam to the calibration apparatus 16A. The remainder of the beam is transmitted via mirror 15 and imaging lens 11 to the target, e.g., the cornea of an eye 50. The beam-shaping mirror 13 can be chosen to reflect only a small portion of the ablative radiation, and the photoreactive element 18 of the calibration apparatus 16A can be chosen from materials which are very sensitive to the ablative radiation, such that only a small fraction of the total beam energy is necessary in order to create a calibration record.
In FIG. 8, an overall ablation system 10A employing a calibration apparatus as part of a feedback control mechanism. As shown, the system 10 A includes a laser, generating a beam of ablative radiation for reprofiling a surface 50, such as the cornea of an eye. The system further includes a beam-shaping assembly 14, a calibration
apparatus 16, an analyzer 42 and a controller 44. As shown, the laser radiation beam, itself, or the output of the beam-shaping assembly 14 can be monitored by the calibration apparatus prior to commencement of the corneal reshaping procedure. If the ablation apparatus determines that the beam shape is correct, the calibration apparatus can be removed from the optical beam path, and the procedure begins. If on the other hand, the calibration apparatus creates a record which the analyzer 42 determines to be unsatisfactory, a feedback control signal is transmitted via controller 44 to the laser or beam shaper in order to effect correction of one or more parameters. The procedure is then repeated until the calibration apparatus indicates that the desired profile will be achieved.
What we claim is:
Claims
1. An apparatus for measuring the properties of a laser beam comprising: a photoreactive element having a composition which reacts with laser radiation in a manner dependent upon an intensity profile of a laser beam; and an alignment means for disposing said photoreactive element in the path of a laser beam, such that the beam can be activated to impinge upon said photoreactive element and the properties of the beam are recorded by changes in the state of the photoreactive element.
2. The apparatus of claim 1 wherein the photoreactive element comprises an erodable element which is ablated by laser radiation in a manner proportional to said intensity profile of the laser beam.
3. The apparatus of claim 2 wherein erodable element further includes an optical indicator which is ablated by laser radiation.
4. The apparatus of claim 3 wherein the optical indicator further comprises an indicator substance chosen from the group consisting of pigments, dyes and fluorescent substances.
5. The apparatus of claim 1 wherein the photoreactive element comprises a radiation-absorbing element having optical properties, which are altered by laser radiation in a manner proportional to said intensity profile of the laser beam.
6. The apparatus of claim 5 wherein the radiating- absorbing element exhibits fluorescence in response to radiation.
7. The apparatus of claim 5 wherein the radiation- absorbing element is bleached in response to radiation.
8. The apparatus of claim 5 wherein the radiation absorbing element is darkened in response to radiation.
9. The apparatus of claim 1 wherein the alignment means further comprises mounting means for mounting the photoreactive element in a fixed position relative to said laser beam.
10. The apparatus of claim 9 wherein the mounting means comprises a backing means to which at least one photoablative element is attached.
11. The apparatus of claim 10, wherein the backing means further comprises an optically transparent material chosen from the group consisting of glass, plastic and quartz.
12. The apparatus of claim 10, wherein the backing means is an optically-reflective material.
13. The apparatus of claim 1 wherein the photoreactive element further comprises a tape.
14. The apparatus of claim 1 wherein the alignment means comprises a tape transport for disposing portions of the tape in the path of the laser beam.
15. The apparatus of claim 1 wherein the apparatus further comprises an optical recording means for reading said, photoreactive element and for storing data indicative of the effects of a laser beam on said photoreactive element.
16. The apparatus of claim 2 wherein the erodable element has a radiation absorption coefficient similar to that of biological tissue at a wavelength of the laser beam.
17. The apparatus of claim 2 wherein the erodable element is 10 to 100 micrometers in thickness.
18. An system for measuring the properties of a laser beam comprising: a photoreactive element having a composition which reacts with laser radiation in a manner dependent upon an intensity profile of a laser beam; an alignment means for disposing said photoreactive element in the path of a laser beam, such that the beam can be activated to impinge upon said photoreactive element; and an optical sensing element for determining the properties of the beam.
19. The system of claim 18 wherein the optical sensing element further comprises a camera for capturing an image of the laser irradiated photoreactive element.
20. The system of claim 18 wherein the optical sensing element further comprises a fluoroscope.
21. The system of claim 18 wherein the optical sensing element further comprises a photodetector.
22. The system of claim 18 wherein the optical sensing element further comprises memory means for storing established parameters representative of an ideal beam.
23. The system of claim 22 wherein the optical sensing element further comprises a processing element for comparing observed properties of the beam with the established parameters stored in the memory element.
24. The system of claim 23 wherein the processing element further comprises output means for reporting the results of a comparison between observed and stored properties of the beam.
25. A method of measuring the properties of a laser beam comprising the steps of: providing a source of laser radiation and means for producing and directing a beam of said laser radiation , directing a laser beam upon a photoreactive element whereby the laser beam changes the photoreactive element in a manner indicative of the intensity profile of the laser radiation.
26. The method according to claim 25 further comprising the step of: shaping the laser beam prior to directing it upon said photoreactive element.
27. The method according to claim 26 further comprising the step of: measuring the radiation transmitted through said photoreactive element to determine the intensity profile of the laser beam.
28. A method of controlling the properties of a laser beam comprising the steps of: directing a laser beam upon a calibration means for generating first signals indicating the intensity profile of said laser beam, modifying the laser beam in response to said first signals.
29. The method according to claim 28 further comprising the step of: analyzing said first signals and generating second signals indicating a deviation of said intensity profile from a predetermined intensity profile.
30. The method according to claim 29 further comprising the step of: providing a controlling means for controlling the intensity profile of said laser beam in response to said second signals.
31. A method of controlling the properties of a laser beam adapted to selectively reprofile a tissue portion, comprising the steps of: providing means for simultaneously directing said laser beam at said tissue portion and a calibration means for indicating the intensity profile of said laser beam, changing the properties of said laser beam in response to said calibration means.
32. A method of controlling the properties of a laser beam adapted to selectively reprofile a tissue portion, comprising the steps of: providing means for simultaneously directing said laser beam at said tissue portion and a calibration means for generating first signals indicating the intensity profile of said laser beam, modifying said laser beam in response to said first signals.
33. The method according to claim 32 further comprising the step of: analyzing said first signals and generating second signals indicating a deviation of said intensity profile from a predetermined intensity profile.
34. The method according to claim 33 further comprising the step of: providing a controlling means for controlling the intensity profile of said laser beam in response to said second signals.
35. A method of measuring the properties of a laser beam comprising the steps of: providing a means for directing said laser beam at a photoreactive element having a composition which reacts with laser radiation in a manner dependent upon an intensity profile of a laser beam, providing alignment means for disposing said photoreactive element in the path of said laser beam whereby said laser beam impinges upon said photoreactive element, directing said laser beam to impinge upon said photoreactive element and recording said intensity profile of said laser beam by changes in said photoreactive element, comparing said intensity profile of said laser beam from said recording with a prescribed intensity profile and modifying said laser beam to have an intensity profile similar to the prescribed intensity profile.
36. A method of measuring the properties of a laser beam comprising the steps of: providing a means for directing said laser beam at a photoreactive element having a composition which reacts with laser radiation in a manner dependent upon the properties of a laser beam, providing alignment means for disposing said photoreactive element in the path of said laser beam whereby said laser beam impinges upon said photoreactive element, directing said laser beam to impinge upon said photoreactive element and recording said properties of said laser beam by changes in said photoreactive element, comparing said properties of said laser beam from said recording with prescribed properties and modifying said laser beam to have properties similar to said prescribed properties.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
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PCT/US1993/004110 WO1994025836A1 (en) | 1993-05-03 | 1993-05-03 | Calibration apparatus for laser ablative systems |
AU43692/93A AU4369293A (en) | 1993-05-03 | 1993-05-03 | Calibration apparatus for laser ablative systems |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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PCT/US1993/004110 WO1994025836A1 (en) | 1993-05-03 | 1993-05-03 | Calibration apparatus for laser ablative systems |
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WO1994025836A1 true WO1994025836A1 (en) | 1994-11-10 |
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PCT/US1993/004110 WO1994025836A1 (en) | 1993-05-03 | 1993-05-03 | Calibration apparatus for laser ablative systems |
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WO (1) | WO1994025836A1 (en) |
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FR2945973A1 (en) * | 2009-05-29 | 2010-12-03 | Datacard Corp | Calibration system of laser engraver parameters for marking on plastic cards, has engraving device that engraves substrate with specific engraved layout and vision system connected to comparison device of measured engraved parameter |
JP2013022634A (en) * | 2011-07-25 | 2013-02-04 | Disco Corp | Method for detecting spot shape of laser beam |
WO2016178104A1 (en) * | 2015-05-06 | 2016-11-10 | Wavelight Gmbh | Method for energy calibration of a pulsed cutting laser for eye surgery |
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JP2018517537A (en) * | 2015-05-06 | 2018-07-05 | バーフェリヒト ゲゼルシャフト ミット ベシュレンクテル ハフツング | Energy calibration method of pulse ablation laser for ophthalmic surgery |
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KR101993911B1 (en) * | 2015-05-06 | 2019-06-27 | 웨이브라이트 게엠베하 | A Method for Energy Calibration of a Pulsed Cutting Laser for Eye Surgery |
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