WO1994024263A1 - Needleless syringe using supersonic gas flow for particle delivery - Google Patents
Needleless syringe using supersonic gas flow for particle delivery Download PDFInfo
- Publication number
- WO1994024263A1 WO1994024263A1 PCT/GB1994/000753 GB9400753W WO9424263A1 WO 1994024263 A1 WO1994024263 A1 WO 1994024263A1 GB 9400753 W GB9400753 W GB 9400753W WO 9424263 A1 WO9424263 A1 WO 9424263A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- particles
- syringe according
- nozzle
- membrane
- syringe
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
- A61M5/3015—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules for injecting a dose of particles in form of powdered drug, e.g. mounted on a rupturable membrane and accelerated by a gaseous shock wave or supersonic gas flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/89—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
- C12N15/895—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection using biolistic methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/42—Reducing noise
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Sustainable Development (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Plant Pathology (AREA)
- Heart & Thoracic Surgery (AREA)
- Mechanical Engineering (AREA)
- Vascular Medicine (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims
Priority Applications (25)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP94912038A EP0693119B1 (en) | 1993-04-08 | 1994-04-08 | Needleless syringe using supersonic gas flow for particle delivery |
GEAP19942903A GEP19991876B (en) | 1993-04-08 | 1994-04-08 | Needleless Syringe, Product Used in Syringe and Therapeutical Method for Treating by Syringe |
RO95-01747A RO118569B1 (en) | 1993-04-08 | 1994-04-08 | Needleless syringe and the use thereof |
JP52287794A JP3260375B2 (en) | 1993-04-08 | 1994-04-08 | Particle input |
RU95119388A RU2129021C1 (en) | 1993-04-08 | 1994-04-08 | Needleless syringe, method of therapeutic treatment with aid of needleless syringe |
KR1019950704408A KR100332147B1 (en) | 1993-04-08 | 1994-04-08 | Particle injector |
SI9430045T SI0693119T1 (en) | 1993-04-08 | 1994-04-08 | Needleless syringe using supersonic gas flow for particle delivery |
AU64351/94A AU674742B2 (en) | 1993-04-08 | 1994-04-08 | Needleless syringe using supersonic gas flow for particle delivery |
CA002159452A CA2159452C (en) | 1993-04-08 | 1994-04-08 | Needleless syringe using supersonic gas flow for particle delivery |
SK1248-95A SK283855B6 (en) | 1993-04-08 | 1994-04-08 | Needleless syringe |
BR9406455A BR9406455A (en) | 1993-04-08 | 1994-04-08 | Needle-free syringe sterile packaging product for therapeutic use and therapeutic treatment process |
HU9802714A HU228144B1 (en) | 1993-04-08 | 1994-04-08 | The use of active ingredient for producing medicament, for transdermal delivery using needleless syringe |
PL94311005A PL174974B1 (en) | 1993-04-08 | 1994-04-08 | Delivery of particles |
TJ95000044A TJ248B (en) | 1993-04-08 | 1994-04-08 | A needleless syringe and a method of therapeutic treatment with using of needleless syringe |
UA95094347A UA41360C2 (en) | 1993-04-08 | 1994-04-08 | Needle-free syringe and method for therapy using needle-free syringe (variants) |
DE69401651T DE69401651T2 (en) | 1993-04-08 | 1994-04-08 | NEEDLE-FREE SYRINGE USING A SUPER-SPEED GAS FLOW FOR PARTICLE ADMINISTRATION |
US08/483,734 US5899880A (en) | 1994-04-08 | 1995-06-07 | Needleless syringe using supersonic gas flow for particle delivery |
BG100047A BG61993B1 (en) | 1993-04-08 | 1995-10-04 | Needleless syringe |
FI954788A FI120671B (en) | 1993-04-08 | 1995-10-06 | Needle-less syringe that utilizes supersonic gas stream for particle feeding |
NO19953994A NO314570B1 (en) | 1993-04-08 | 1995-10-06 | Nållös spröyte for delivery of particles to a living patient as well as a product for therapeutic use |
GR970400626T GR3022939T3 (en) | 1993-04-08 | 1997-03-26 | Needleless syringe using supersonic gas flow for particle delivery |
HK97101908A HK1000351A1 (en) | 1993-04-08 | 1997-10-09 | Needleless syringe using supersonic gas flow for particle delivery |
US09/248,743 US6881200B2 (en) | 1993-04-08 | 1999-02-10 | Needleless syringe using super sonic gas flow for particle delivery |
US10/314,336 US7618394B2 (en) | 1993-04-08 | 2002-12-09 | Needleless syringe using supersonic gas flow for particle delivery |
US11/848,432 US7942846B2 (en) | 1993-04-08 | 2007-08-31 | Needleless syringe using supersonic gas flow for particle delivery |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939307459A GB9307459D0 (en) | 1993-04-08 | 1993-04-08 | Particle delivery apparatus |
GB9307459.9 | 1993-04-08 | ||
GB939318407A GB9318407D0 (en) | 1993-09-06 | 1993-09-06 | Particle delivery apparatus |
GB9318407.5 | 1993-09-06 | ||
GB939321356A GB9321356D0 (en) | 1993-10-15 | 1993-10-15 | Particle delivery apparatus |
GB9321356.9 | 1993-10-15 | ||
GB939326069A GB9326069D0 (en) | 1993-12-21 | 1993-12-21 | Particle delivery apparatus |
GB9326069.3 | 1993-12-21 |
Related Child Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08525537 A-371-Of-International | 1994-04-08 | ||
US08/483,734 Continuation US5899880A (en) | 1994-04-08 | 1995-06-07 | Needleless syringe using supersonic gas flow for particle delivery |
US08/986,124 Continuation US6168587B1 (en) | 1993-04-08 | 1997-12-05 | Needleless syringe using supersonic gas flow for particle delivery |
US09/248,743 Continuation US6881200B2 (en) | 1993-04-08 | 1999-02-10 | Needleless syringe using super sonic gas flow for particle delivery |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1994024263A1 true WO1994024263A1 (en) | 1994-10-27 |
Family
ID=27451010
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1994/000753 WO1994024263A1 (en) | 1993-04-08 | 1994-04-08 | Needleless syringe using supersonic gas flow for particle delivery |
Country Status (32)
Country | Link |
---|---|
US (5) | US5630796A (en) |
EP (4) | EP1637173B1 (en) |
JP (4) | JP3260375B2 (en) |
KR (1) | KR100332147B1 (en) |
CN (1) | CN1109102C (en) |
AT (2) | ATE329006T1 (en) |
AU (1) | AU674742B2 (en) |
BG (1) | BG61993B1 (en) |
BR (1) | BR9406455A (en) |
CA (1) | CA2159452C (en) |
CZ (1) | CZ290476B6 (en) |
DE (2) | DE69434760T2 (en) |
DK (2) | DK0693119T3 (en) |
ES (2) | ES2098131T3 (en) |
FI (1) | FI120671B (en) |
GR (1) | GR3022939T3 (en) |
HK (1) | HK1000351A1 (en) |
HU (2) | HU228144B1 (en) |
LV (1) | LV11833B (en) |
NO (1) | NO314570B1 (en) |
NZ (1) | NZ263606A (en) |
OA (1) | OA10234A (en) |
PL (1) | PL174974B1 (en) |
PT (1) | PT734737E (en) |
RO (1) | RO118569B1 (en) |
RU (1) | RU2129021C1 (en) |
SI (2) | SI0693119T1 (en) |
SK (1) | SK283855B6 (en) |
TJ (1) | TJ248B (en) |
TW (2) | TW360548B (en) |
UA (1) | UA41360C2 (en) |
WO (1) | WO1994024263A1 (en) |
Cited By (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996020022A1 (en) * | 1994-12-23 | 1996-07-04 | Powderject Research Limited | Particle delivery |
WO1996025190A1 (en) * | 1995-02-14 | 1996-08-22 | Powderject Research Limited | Trans-mucosal particle delivery |
US5584807A (en) * | 1994-01-21 | 1996-12-17 | Agracetus, Inc. | Gas driven gene delivery instrument |
EP0757202A2 (en) | 1995-08-02 | 1997-02-05 | The BOC Group plc | Gas delivery system |
EP0757203A2 (en) * | 1995-08-02 | 1997-02-05 | The BOC Group plc | Gas capsule |
WO1997034652A1 (en) * | 1996-03-19 | 1997-09-25 | Powderject Research Limited | Needleless syringe with therapeutic agent particles entrained in supersonic gas flow |
EP0821195A2 (en) | 1996-07-24 | 1998-01-28 | The BOC Group plc | Gas capsule and gas delivery system |
EP0826059A1 (en) * | 1995-05-04 | 1998-03-04 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus and method for delivering a nucleotide into cell nuclei |
WO1998031409A2 (en) * | 1997-01-17 | 1998-07-23 | Roche Diagnostics Gmbh | Hypodermic injection system |
EP0888791A1 (en) * | 1997-07-04 | 1999-01-07 | PowderJect Research Limited | Syringe and drug capsule therefor |
EP0888790A1 (en) * | 1997-07-04 | 1999-01-07 | PowderJect Research Limited | Drug particle delivery device |
WO1999004838A1 (en) | 1997-07-21 | 1999-02-04 | Roche Diagnostics Gmbh | Electromagnetic transdermal injection device and methods related thereto |
WO1999026662A1 (en) * | 1997-11-20 | 1999-06-03 | Aventis Pasteur | A method for in vivo dna delivery using a needle free apparatus |
WO1999027961A1 (en) * | 1997-12-02 | 1999-06-10 | Powderject Vaccines, Inc. | Transdermal delivery of particulate vaccine compositions |
WO1999031262A2 (en) * | 1997-12-16 | 1999-06-24 | Valentis, Inc. | Needle-free injection of formulated nucleic acid molecules |
EP0934753A2 (en) | 1998-02-05 | 1999-08-11 | The BOC Group plc | Needleless medical device for delivering of terapeutic agent |
EP0934754A2 (en) | 1998-02-05 | 1999-08-11 | The BOC Group plc | Needleless medical device for delivering of therapeutic agent |
US6013050A (en) * | 1995-10-20 | 2000-01-11 | Powderject Research Limited | Particle delivery |
WO2000013573A1 (en) | 1998-09-04 | 2000-03-16 | Powderject Research Limited | Monitoring methods using particle delivery methods |
WO2000019982A1 (en) * | 1998-10-01 | 2000-04-13 | Powderject Research Limited | Spray coated microparticles for use in needleless syringes |
US6135170A (en) * | 1998-11-25 | 2000-10-24 | The Boc Group Plc | Filling containers with gas |
US6171276B1 (en) | 1997-08-06 | 2001-01-09 | Pharmacia & Upjohn Ab | Automated delivery device and method for its operation |
FR2796290A1 (en) * | 1999-07-16 | 2001-01-19 | Cross Site Technologies | NEEDLELESS SYRINGE OPERATING WITH A SHOCK WAVE GENERATOR THROUGH A WALL |
US6221051B1 (en) | 1996-07-01 | 2001-04-24 | Pharmacia Ab | Delivery device and method for its operation |
WO2001041840A1 (en) * | 1999-12-08 | 2001-06-14 | Crossject | Needless syringe provided with an ejection tube with a constant cross-section |
FR2802820A1 (en) * | 1999-12-27 | 2001-06-29 | Poudres & Explosifs Ste Nale | Needleless syringe has pyrotechnic gas generator to eject solid particles by tube shock effect |
FR2804329A1 (en) | 2000-02-02 | 2001-08-03 | Poudres & Explosifs Ste Nale | SYRINGE WITHOUT NEEDLE PROVIDED WITH A LID CONTAINING THE ACTIVE INGREDIENT |
US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
EP1138337A2 (en) * | 1994-08-04 | 2001-10-04 | Quadrant Holdings Cambridge Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
WO2002030275A1 (en) | 2000-10-13 | 2002-04-18 | Precisense A/S | Optical sensor for in situ measurement of analytes |
US6468782B1 (en) | 1996-12-05 | 2002-10-22 | Quadrant Healthcare (Uk) Limited | Methods of preserving prokaryotic cells and compositions obtained thereby |
WO2003004055A2 (en) | 2000-11-27 | 2003-01-16 | Powderject Vaccines, Inc. | Nucleic acid adjuvants |
WO2003011380A2 (en) | 2001-07-26 | 2003-02-13 | Powderject Research Limited | Silencing device and method for needleless syringe |
US6521745B1 (en) | 1998-08-20 | 2003-02-18 | Aventis Pasteur Limited | Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia |
WO2003052125A1 (en) | 2001-12-17 | 2003-06-26 | Powderject Research Limited | Non-or minimally invasive monitoring methods |
US6586006B2 (en) | 1994-08-04 | 2003-07-01 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
US6602678B2 (en) | 1998-09-04 | 2003-08-05 | Powderject Research Limited | Non- or minimally invasive monitoring methods |
US6686339B1 (en) | 1998-08-20 | 2004-02-03 | Aventis Pasteur Limited | Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia |
US6693087B1 (en) | 1998-08-20 | 2004-02-17 | Aventis Pasteur Limited | Nucleic acid molecules encoding POMP91A protein of Chlamydia |
DE10306716A1 (en) * | 2003-02-17 | 2004-09-02 | Lell, Peter, Dr.-Ing. | Device for injecting a dust or powdered substance into a tissue of a body |
US6811783B1 (en) | 1999-09-07 | 2004-11-02 | Aventis Pasteur Limited | Immunogenic compositions for protection against chlamydial infection |
DE10316237A1 (en) * | 2003-04-09 | 2004-11-04 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Cannula for insertion in biological organ, clasps a hollow needle with a needle end which carries a covering device separating the interior of the needle from the environment |
US6881723B1 (en) | 1998-11-05 | 2005-04-19 | Powderject Vaccines, Inc. | Nucleic acid constructs |
US6893664B1 (en) | 1996-06-17 | 2005-05-17 | Powderject Research Limited | Particle delivery techniques |
US6913593B1 (en) | 1999-12-08 | 2005-07-05 | Crossject | Needleless syringe which functions with the active agent being driven by a shocktube effect |
US6932789B2 (en) | 2000-03-03 | 2005-08-23 | Boehringer Ingelheim International Gmbh | Needle-less injector of miniature type |
US7013617B2 (en) | 1999-04-01 | 2006-03-21 | The Boc Group, Plc | Method of filling and sealing |
US7022320B1 (en) | 1999-02-09 | 2006-04-04 | Powderject Vaccines, Inc. | Mycobacterium tuberculosis immunization |
US7022313B2 (en) | 1999-02-03 | 2006-04-04 | Powderject Research Ltd. | Hydrogel particle formulation |
DE102005015801A1 (en) * | 2005-04-06 | 2006-10-19 | Schreiner Group Gmbh & Co. Kg | Foil-based protection mechanism |
EP1741782A2 (en) | 2000-05-10 | 2007-01-10 | Sanofi Pasteur Limited | Immunogenic polypeptides encoded by MAGE minigenes and uses thereof |
US7196066B1 (en) | 1999-11-03 | 2007-03-27 | Powderject Vaccines, Inc. | DNA-vaccines based on constructs derived from the genomes of human and animal pathogens |
US7223739B1 (en) | 1995-06-07 | 2007-05-29 | Powderject Vaccines, Inc. | Adjuvanted genetic vaccines |
EP1792995A2 (en) | 2000-05-08 | 2007-06-06 | Sanofi Pasteur Limited | Chlamydia secretory locus orf and uses thereof |
EP1964573A2 (en) | 1999-10-22 | 2008-09-03 | Aventis Pasteur Limited | Method of inducing and/or enhancing an immune response to tumor antigens |
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US7638332B2 (en) * | 2003-02-03 | 2009-12-29 | Bioware Technology Co., Ltd. | Low pressure gas accelerated gene gun |
US7666844B2 (en) | 1999-04-16 | 2010-02-23 | Novo Nordisk A/S | Dry mouldable drug formulation |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW360548B (en) | 1993-04-08 | 1999-06-11 | Powderject Res Ltd | Products for therapeutic use |
US5899880A (en) * | 1994-04-08 | 1999-05-04 | Powderject Research Limited | Needleless syringe using supersonic gas flow for particle delivery |
GB9416663D0 (en) * | 1994-08-17 | 1994-10-12 | Oxford Bioscience Limited | Particle delivery |
US6474369B2 (en) | 1995-05-26 | 2002-11-05 | Penjet Corporation | Apparatus and method for delivering a lyophilized active with a needle-less injector |
US6080130A (en) * | 1998-11-14 | 2000-06-27 | Castellano; Thomas P. | Gas power source for a needle-less injector |
CA2257141C (en) * | 1996-06-14 | 2006-11-28 | Powderject Vaccines, Inc. | Sample delivery module for particle acceleration apparatus |
US5947928A (en) * | 1997-06-19 | 1999-09-07 | Mile Creek Capital, Llc | Drug delivery system |
DE19820172A1 (en) * | 1997-09-30 | 2005-01-27 | Wolfgang Wagner | Injection arrangement for inserting a diagnostic carrier or medicament beneath a patient's skin has a compressed gas source and a valve closure for controlling the release of the gas that is used to inject a substance |
GB9818627D0 (en) * | 1998-08-26 | 1998-10-21 | Glaxo Group Ltd | Improvements in dva vaccination |
GB9819272D0 (en) * | 1998-09-03 | 1998-10-28 | Andaris Ltd | Microparticles |
JP2002524741A (en) * | 1998-09-04 | 2002-08-06 | パウダージェクト リサーチ リミテッド | Immunodiagnosis using particle delivery methods |
USD434848S (en) * | 1998-09-08 | 2000-12-05 | Powderject Research Limited | Disposable injector |
DE69930294T2 (en) * | 1998-10-19 | 2006-11-02 | Powderject Vaccines, Inc., Madison | MINIMUM PROMOTERS AND THEIR USE |
US6264629B1 (en) | 1998-11-18 | 2001-07-24 | Bioject, Inc. | Single-use needle-less hypodermic jet injection apparatus and method |
WO2000043058A1 (en) * | 1999-01-22 | 2000-07-27 | Powderject Research Limited | Method of enhancing needleless transdermal powdered drug delivery |
US20070196490A1 (en) * | 1999-01-22 | 2007-08-23 | Powderject Research Limited | Method of enhancing needleless transdermal powered drug delivery |
US6849060B1 (en) * | 1999-01-29 | 2005-02-01 | Powderject Research Limited | Particle delivery device |
US6328714B1 (en) | 1999-01-29 | 2001-12-11 | Powderject Research Limited | Particle delivery device |
JP2002538195A (en) * | 1999-03-08 | 2002-11-12 | パウダージェクト リサーチ リミテッド | Delivery of microparticulate formulations using needle-free injectors for sustained release of bioactive compounds |
US20050214227A1 (en) * | 1999-03-08 | 2005-09-29 | Powderject Research Limited | Microparticle formulations for sustained-release of bioactive compounds |
GB9905933D0 (en) * | 1999-03-15 | 1999-05-05 | Powderject Res Ltd | Neeedleless syringe |
KR100702653B1 (en) * | 1999-04-16 | 2007-04-02 | 파우더젝트 리서치 리미티드 | Needleless syringe |
US7060048B1 (en) * | 1999-04-16 | 2006-06-13 | Powerject Research Limited | Needleless syringe |
GB9916800D0 (en) * | 1999-07-16 | 1999-09-22 | Powderject Res Ltd | Needleless syringe |
FR2796288B1 (en) * | 1999-07-16 | 2001-08-10 | Cross Site Technologies | NEEDLELESS SYRINGE WITH FITTED ELEMENT INJECTOR |
US20050027239A1 (en) * | 1999-08-20 | 2005-02-03 | Stout Richard R. | Intradermal injection system for injecting DNA-based injectables into humans |
US6319224B1 (en) * | 1999-08-20 | 2001-11-20 | Bioject Medical Technologies Inc. | Intradermal injection system for injecting DNA-based injectables into humans |
DE19946059A1 (en) * | 1999-09-25 | 2001-03-29 | Roche Diagnostics Gmbh | System for the transdermal production of body fluid |
GB9923306D0 (en) | 1999-10-01 | 1999-12-08 | Isis Innovation | Diagnostic and therapeutic epitope, and transgenic plant |
US6626871B1 (en) | 1999-10-11 | 2003-09-30 | Felton International, Inc. | Method and apparatus for removing cap from medical device |
DK1142590T3 (en) * | 1999-10-29 | 2009-01-26 | Anges Mg Inc | Gene therapy for diabetic ischemic disease |
US20040234539A1 (en) * | 1999-11-03 | 2004-11-25 | Powderject Research Limited | Nucleic acid vaccine compositions having a mammalian cd80/cd86 gene promoter driving antigen expression |
FR2800619B1 (en) * | 1999-11-05 | 2002-02-08 | Cross Site Technologies | NEEDLELESS SYRINGE WITH TEMPORARILY RETAINED PUSHING MEDIA |
US20040109874A1 (en) * | 1999-11-10 | 2004-06-10 | Powderject Vaccines, Inc. | Induction of mucosal immunity by vaccination via the skin route |
US7029457B2 (en) | 1999-11-23 | 2006-04-18 | Felton International, Inc. | Jet injector with hand piece |
US6770054B1 (en) | 1999-11-23 | 2004-08-03 | Felton International, Inc. | Injector assembly with driving means and locking means |
US7887506B1 (en) | 1999-11-23 | 2011-02-15 | Pulse Needlefree Systems, Inc. | Safety mechanism to prevent accidental patient injection and methods of same |
GB0006263D0 (en) * | 2000-03-15 | 2000-05-03 | Powderject Res Ltd | Apparatus and method for adjusting the characteristics of a needleless syringe |
US6716190B1 (en) * | 2000-04-19 | 2004-04-06 | Scimed Life Systems, Inc. | Device and methods for the delivery and injection of therapeutic and diagnostic agents to a target site within a body |
AU2001268762A1 (en) * | 2000-05-26 | 2001-12-03 | George Vizirgianakis | Treatment and therapy apparatus |
US20040213798A1 (en) * | 2000-06-08 | 2004-10-28 | Powderject Vaccines, Inc. | Spray-dried alum compositions |
US7597692B2 (en) * | 2000-06-08 | 2009-10-06 | Massachusetts Institute Of Technology | Microscission processes and procedures |
EP1289494A2 (en) * | 2000-06-08 | 2003-03-12 | Powderject Vaccines, Inc. | Powder compositions |
US20020120228A1 (en) * | 2000-06-08 | 2002-08-29 | Yuh-Fun Maa | Powder compositions |
US6706032B2 (en) * | 2000-06-08 | 2004-03-16 | Massachusetts Institute Of Technology | Localized molecular and ionic transport to and from tissues |
GB0018035D0 (en) | 2000-07-21 | 2000-09-13 | Powderject Res Ltd | Needleless syringe |
US20020051821A1 (en) * | 2000-09-08 | 2002-05-02 | Sung-Yun Kwon | Aliginate particle formulation |
US6824822B2 (en) * | 2001-08-31 | 2004-11-30 | Alkermes Controlled Therapeutics Inc. Ii | Residual solvent extraction method and microparticles produced thereby |
US6981660B2 (en) * | 2000-09-25 | 2006-01-03 | Evit Labs | Shock wave aerosolization apparatus and method |
AU2001294742A1 (en) * | 2000-09-25 | 2002-04-02 | Evit Laboratories, Inc. | Shock wave aerosolization apparatus and method |
US7931614B2 (en) * | 2000-11-30 | 2011-04-26 | Valeritas, Inc. | Injection systems |
US6443152B1 (en) | 2001-01-12 | 2002-09-03 | Becton Dickinson And Company | Medicament respiratory delivery device |
US6644309B2 (en) * | 2001-01-12 | 2003-11-11 | Becton, Dickinson And Company | Medicament respiratory delivery device and method |
US6722364B2 (en) * | 2001-01-12 | 2004-04-20 | Becton, Dickinson And Company | Medicament inhalation delivery devices and methods for using the same |
ES2191528B1 (en) * | 2001-02-05 | 2004-06-16 | Danone, S.A. | DEVICE FOR THE DOSAGE OF LIQUID SUBSTANCES. |
GB0103348D0 (en) * | 2001-02-10 | 2001-03-28 | Medical Res Council | Delivery of biologically active agents |
JP2004529754A (en) | 2001-03-14 | 2004-09-30 | ペンジェット・コーポレーション | System and method for removing dissolved gases from a solution |
AU2002252378B2 (en) | 2001-03-19 | 2007-10-18 | Intercell Usa, Inc. | Transcutaneous immunostimulation |
US20050192530A1 (en) * | 2001-04-13 | 2005-09-01 | Penjet Corporation | Method and apparatus for needle-less injection with a degassed fluid |
US6613010B2 (en) | 2001-04-13 | 2003-09-02 | Penjet Corporation | Modular gas-pressured needle-less injector |
WO2002087663A2 (en) | 2001-04-27 | 2002-11-07 | Penjet Corporation | Method and apparatus for filling or refilling a needle-less injector |
DE10121255A1 (en) * | 2001-04-30 | 2002-11-07 | Switch Biotech Ag | Use of alpha 1-antichymotrypsin polypeptide or nucleic acids encoding the polypeptide, or of a cell expressing the polypeptide, or of antibody against the polypeptide, for diagnosing, treating or preventing poorly-healing wounds |
US6648850B2 (en) * | 2001-06-08 | 2003-11-18 | Bioject, Inc. | Durable needle-less jet injector apparatus and method |
EP1399131A2 (en) * | 2001-06-08 | 2004-03-24 | Powderject Vaccines, Inc. | Spray freeze-dried compositions |
US20030019558A1 (en) * | 2001-07-26 | 2003-01-30 | Smith Edward R. | Particle cassette, method and kit therefor |
PT1409045E (en) * | 2001-07-26 | 2009-05-18 | Powderject Res Ltd | Particle cassette, method and kit therefor |
US8061006B2 (en) * | 2001-07-26 | 2011-11-22 | Powderject Research Limited | Particle cassette, method and kit therefor |
DE20112501U1 (en) * | 2001-07-30 | 2002-12-19 | Disetronic Licensing Ag | Locking lock for connecting housing parts of an injection or infusion device |
DE10163325B4 (en) * | 2001-07-30 | 2005-07-28 | Tecpharma Licensing Ag | Locking lock for connection of housing sections of an administering device |
DE10163328B4 (en) * | 2001-07-30 | 2005-08-11 | Tecpharma Licensing Ag | Administration device with anti-rotation device |
DE10163326A1 (en) * | 2001-07-30 | 2003-02-27 | Disetronic Licensing Ag | Administration device with dosing device |
DE10163327A1 (en) | 2001-07-30 | 2003-02-27 | Disetronic Licensing Ag | Reservoir module with piston rod |
US20050191361A1 (en) * | 2001-08-03 | 2005-09-01 | Powederject Research Ltd. | Hydrogel particle formation |
US6824526B2 (en) | 2001-10-22 | 2004-11-30 | Penjet Corporation | Engine and diffuser for use with a needle-less injector |
AU2002366267B2 (en) * | 2001-11-19 | 2007-05-10 | Becton, Dickinson And Company | Pharmaceutical compositions in particulate form |
DE20209051U1 (en) | 2001-12-21 | 2003-04-24 | Disetronic Licensing Ag | Medicament administration device has dosage adjuster mounted on piston rod and end stop mounted at end of its path, locking system preventing adjuster from rotating and pressing against stop |
US20030130614A1 (en) * | 2002-01-09 | 2003-07-10 | Johnson Lanny L. | Device for delivering liquid medications or nutrients and gases to local tissue |
RU2279898C2 (en) | 2002-02-18 | 2006-07-20 | Данфосс А/С | Device for introducing liquid medicaments |
US20030163111A1 (en) * | 2002-02-26 | 2003-08-28 | Daellenbach Keith K. | End effector for needle-free injection system |
CA2380671A1 (en) * | 2002-04-05 | 2003-10-05 | Stephane Dufresne | Needleless syringe for the subcutaneous injection of medicated droplets |
US7334580B2 (en) * | 2002-05-07 | 2008-02-26 | Smaldone Gerald C | Methods, devices and formulations for targeted endobronchial therapy |
US7607436B2 (en) * | 2002-05-06 | 2009-10-27 | The Research Foundation Of State University Of New York | Methods, devices and formulations for targeted endobronchial therapy |
US7156823B2 (en) * | 2002-06-04 | 2007-01-02 | Bioject Inc. | High workload needle-free injection system |
GB0212885D0 (en) | 2002-06-05 | 2002-07-17 | Isis Innovation | Therapeutic epitopes and uses thereof |
CA2500713C (en) * | 2002-10-04 | 2012-07-03 | Photokinetix, Inc. | Photokinetic delivery of biologically active substances using pulsed incoherent light |
MXPA05010221A (en) * | 2003-03-25 | 2006-02-22 | Terry O Herndon | Drill device and method for forming microconduits. |
JP2006524120A (en) * | 2003-04-21 | 2006-10-26 | ストラテージェント ライフ サイエンシズ | Apparatus and method for repetitively delivering drug by microjet |
US20060184101A1 (en) * | 2003-04-21 | 2006-08-17 | Ravi Srinivasan | Microjet devices and methods for drug delivery |
WO2004110533A1 (en) * | 2003-05-09 | 2004-12-23 | Anges Mg, Inc. | Needleless syringe having medical agent accommodated therein |
AU2004246870B2 (en) | 2003-06-13 | 2009-07-23 | Skendi Finance Ltd | Slow release estradiol-progesterone formulation for contraception and hormone replacement therapy |
US7131961B2 (en) * | 2003-10-01 | 2006-11-07 | Bioject, Inc. | Needle-free injection system |
AU2004279991B2 (en) * | 2003-10-10 | 2010-11-25 | Powderject Vaccines, Inc. | Nucleic acid constructs |
US7442182B2 (en) * | 2003-10-24 | 2008-10-28 | Bioject, Inc. | Spring powered needle-free injection system |
US8147426B2 (en) * | 2003-12-31 | 2012-04-03 | Nipro Diagnostics, Inc. | Integrated diagnostic test system |
US20050209554A1 (en) * | 2004-03-19 | 2005-09-22 | Sergio Landau | Needle-free single-use cartridge and injection system |
US20050209553A1 (en) * | 2004-03-19 | 2005-09-22 | Sergio Landau | Needle-free single-use cartridge and injection system |
JP4210231B2 (en) * | 2004-03-25 | 2009-01-14 | 株式会社資生堂 | Cosmetic method for improving skin wrinkles and wrinkle improving tool |
US7456254B2 (en) | 2004-04-15 | 2008-11-25 | Alkermes, Inc. | Polymer-based sustained release device |
US20060110423A1 (en) * | 2004-04-15 | 2006-05-25 | Wright Steven G | Polymer-based sustained release device |
CN1968700A (en) * | 2004-04-15 | 2007-05-23 | 阿尔克姆斯有限公司 | Polymer-based sustained release device |
NZ550600A (en) | 2004-04-28 | 2010-03-26 | Btg Int Ltd | Epitopes related to coeliac disease |
US10105437B2 (en) | 2004-04-28 | 2018-10-23 | Btg International Limited | Epitopes related to coeliac disease |
US7717874B2 (en) * | 2004-05-28 | 2010-05-18 | Bioject, Inc. | Needle-free injection system |
US20060038044A1 (en) * | 2004-08-23 | 2006-02-23 | Van Steenkiste Thomas H | Replaceable throat insert for a kinetic spray nozzle |
US20060089593A1 (en) * | 2004-10-26 | 2006-04-27 | Sergio Landau | Needle-free injection device for individual users |
US20060089594A1 (en) * | 2004-10-26 | 2006-04-27 | Sergio Landau | Needle-free injection device |
JP4904283B2 (en) | 2004-12-01 | 2012-03-28 | アキュショット インク | Needleless syringe |
JP2008526229A (en) * | 2005-01-06 | 2008-07-24 | ベニテック,インコーポレーテッド | RNAi agents for stem cell maintenance |
GB0507997D0 (en) * | 2005-02-01 | 2005-05-25 | Powderject Vaccines Inc | Nucleic acid constructs |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
WO2006091459A2 (en) | 2005-02-24 | 2006-08-31 | Joslin Diabetes Center, Inc. | Compositions and methods for treating vascular permeability |
US20070118093A1 (en) * | 2005-06-20 | 2007-05-24 | Von Muhlen Marcio G | High-speed jet devices for drug delivery |
US20070055199A1 (en) * | 2005-08-10 | 2007-03-08 | Gilbert Scott J | Drug delivery device for buccal and aural applications and other areas of the body difficult to access |
CN101242869B (en) | 2005-09-02 | 2010-05-26 | Iomai公司 | Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs and uses thereof |
US8142391B2 (en) * | 2005-11-29 | 2012-03-27 | Mitchell Stuart B | Electrostatic transcutaneous hypodermic spray (electrostatic hypospray) |
US20080161755A1 (en) * | 2006-01-27 | 2008-07-03 | Bioject Inc. | Needle-free injection device and priming system |
RU2008129182A (en) | 2006-01-31 | 2010-03-10 | Ново Нордиск А/С (DK) | INSULATING COMPONENT FOR PRE-FILLED MEDICAL JET INJECTOR |
KR101200728B1 (en) | 2006-08-09 | 2012-11-13 | 인타르시아 세라퓨틱스 인코포레이티드 | Osmotic delivery system and piston assemblies |
CN100446823C (en) * | 2006-09-19 | 2008-12-31 | 宁波新芝生物科技股份有限公司 | A non-traumatic interfere treatment system |
US7547293B2 (en) | 2006-10-06 | 2009-06-16 | Bioject, Inc. | Triggering mechanism for needle-free injector |
EP2077821B1 (en) | 2006-10-12 | 2019-08-14 | The University Of Queensland | Compositions and methods for modulating immune responses |
FR2908753B1 (en) * | 2006-11-16 | 2011-11-11 | Becton Dickinson France | DEVICE FOR AUTOMATICALLY DELIVERING SUCCESSIVE PRODUCT DOSES |
DE102007004855B4 (en) * | 2007-01-31 | 2014-03-27 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Apparatus and method for deposition of biological material in a target substrate |
JP2008199905A (en) * | 2007-02-16 | 2008-09-04 | Snow Brand Milk Prod Co Ltd | Improving agent for survivability of lactic acid bacterium |
WO2008103997A2 (en) * | 2007-02-23 | 2008-08-28 | Bioject Inc. | Needle-free injection devices and drug delivery systems therefor |
AU2008244523B2 (en) | 2007-04-23 | 2012-02-16 | Intarcia Therapeutics, Inc. | Suspension formulations of insulinotropic peptides and uses thereof |
CN101754682B (en) | 2007-05-16 | 2014-11-12 | 布里格姆妇女医院 | Treatment of synucleinopathies |
JP4780034B2 (en) * | 2007-05-18 | 2011-09-28 | 株式会社島津製作所 | Needleless syringe |
PL2612868T3 (en) | 2007-11-01 | 2018-12-31 | Astellas Pharma Inc. | Immunosuppressive polypeptides and nucleic acids |
EP2240155B1 (en) | 2008-02-13 | 2012-06-06 | Intarcia Therapeutics, Inc | Devices, formulations, and methods for delivery of multiple beneficial agents |
US20110117673A1 (en) * | 2008-07-16 | 2011-05-19 | Johnson Brandon T | Methods and systems to collect and prepare samples, to implement, initiate and perform assays, and to control and manage fluid flow |
US8021873B2 (en) | 2008-07-16 | 2011-09-20 | Boston Microfluidics | Portable, point-of-care, user-initiated fluidic assay methods and systems |
US8658350B2 (en) | 2008-09-22 | 2014-02-25 | Oregon Health & Science University | Methods for detecting Mycobacterium tuberculosis disease |
DE102008048981A1 (en) * | 2008-09-25 | 2010-04-15 | Lts Lohmann Therapie-Systeme Ag | Injector and two-chamber system with sterile components |
US9207242B2 (en) | 2008-10-09 | 2015-12-08 | The University Of Hong Kong | Cadherin-17 as diagnostic marker and therapeutic target for liver cancer |
US20100111857A1 (en) | 2008-10-31 | 2010-05-06 | Boyden Edward S | Compositions and methods for surface abrasion with frozen particles |
US8725420B2 (en) | 2008-10-31 | 2014-05-13 | The Invention Science Fund I, Llc | Compositions and methods for surface abrasion with frozen particles |
US9050070B2 (en) | 2008-10-31 | 2015-06-09 | The Invention Science Fund I, Llc | Compositions and methods for surface abrasion with frozen particles |
US20100111834A1 (en) * | 2008-10-31 | 2010-05-06 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Compositions and methods for therapeutic delivery with frozen particles |
US8409376B2 (en) | 2008-10-31 | 2013-04-02 | The Invention Science Fund I, Llc | Compositions and methods for surface abrasion with frozen particles |
US9072799B2 (en) | 2008-10-31 | 2015-07-07 | The Invention Science Fund I, Llc | Compositions and methods for surface abrasion with frozen particles |
US9060934B2 (en) | 2008-10-31 | 2015-06-23 | The Invention Science Fund I, Llc | Compositions and methods for surface abrasion with frozen particles |
US8731841B2 (en) * | 2008-10-31 | 2014-05-20 | The Invention Science Fund I, Llc | Compositions and methods for therapeutic delivery with frozen particles |
US9072688B2 (en) * | 2008-10-31 | 2015-07-07 | The Invention Science Fund I, Llc | Compositions and methods for therapeutic delivery with frozen particles |
US8793075B2 (en) | 2008-10-31 | 2014-07-29 | The Invention Science Fund I, Llc | Compositions and methods for therapeutic delivery with frozen particles |
US9060926B2 (en) * | 2008-10-31 | 2015-06-23 | The Invention Science Fund I, Llc | Compositions and methods for therapeutic delivery with frozen particles |
US8551505B2 (en) * | 2008-10-31 | 2013-10-08 | The Invention Science Fund I, Llc | Compositions and methods for therapeutic delivery with frozen particles |
US8545855B2 (en) * | 2008-10-31 | 2013-10-01 | The Invention Science Fund I, Llc | Compositions and methods for surface abrasion with frozen particles |
US8731840B2 (en) | 2008-10-31 | 2014-05-20 | The Invention Science Fund I, Llc | Compositions and methods for therapeutic delivery with frozen particles |
US9050317B2 (en) | 2008-10-31 | 2015-06-09 | The Invention Science Fund I, Llc | Compositions and methods for therapeutic delivery with frozen particles |
US8762067B2 (en) * | 2008-10-31 | 2014-06-24 | The Invention Science Fund I, Llc | Methods and systems for ablation or abrasion with frozen particles and comparing tissue surface ablation or abrasion data to clinical outcome data |
US8788211B2 (en) * | 2008-10-31 | 2014-07-22 | The Invention Science Fund I, Llc | Method and system for comparing tissue ablation or abrasion data to data related to administration of a frozen particle composition |
US8721583B2 (en) | 2008-10-31 | 2014-05-13 | The Invention Science Fund I, Llc | Compositions and methods for surface abrasion with frozen particles |
EP2405961A4 (en) * | 2009-03-09 | 2012-08-08 | Purdue Research Foundation | Compact device for rapidly mixing and delivering substances to a patient |
WO2010105096A2 (en) | 2009-03-11 | 2010-09-16 | University Of Massachusetts | Modulation of human cytomegalovirus replication by micro-rna 132 (mir132), micro-rna 145 (mir145) and micro-rna 212 (mir212) |
EP2756845B1 (en) | 2009-04-03 | 2017-03-15 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of KRAS by asymmetric double-stranded RNA |
GB0906215D0 (en) | 2009-04-09 | 2009-05-20 | Lalvani Ajit | Diagnostic test |
TWI439302B (en) | 2009-07-14 | 2014-06-01 | Chien Lung Chen | Transportation device |
CN101987218B (en) * | 2009-07-30 | 2013-07-10 | 陈建龙 | Transmission device |
SI2462246T1 (en) | 2009-09-28 | 2018-01-31 | Intarcia Therapeutics, Inc. | Rapid establishment and/or termination of substantial steady-state drug delivery |
US20120208750A1 (en) | 2009-09-29 | 2012-08-16 | Joslin Diabetes Center, Inc. | Use of protein kinase c delta (pkcd) inhibitors to treat diabetes, obesity, and hepatic steatosis |
EP2501397B1 (en) | 2009-11-20 | 2017-10-04 | Oregon Health and Science University | Methods for producing an immune response to tuberculosis |
WO2011063349A1 (en) * | 2009-11-20 | 2011-05-26 | Talima Therapeutics, Inc. | Devices for implanting compositions and methods and kits therefor |
CN201888971U (en) * | 2010-01-08 | 2011-07-06 | 江苏华兰米特医疗科技有限公司 | Needleless injector |
US20130012916A1 (en) | 2010-02-11 | 2013-01-10 | Glide Pharmaceutical Technologies Limited | Delivery of immunoglobulin variable domains and constructs thereof |
CN101797411B (en) * | 2010-03-18 | 2011-12-07 | 傅雅芬 | Air-pressure type needleless injector power head |
WO2011123762A1 (en) * | 2010-04-01 | 2011-10-06 | Glucago Llc | Method and device for mixing substances |
US8821434B2 (en) * | 2010-10-07 | 2014-09-02 | Massachusetts Institute Of Technology | Delivery of a solid body and/or a fluid using a linear Lorentz-force actuated needle-free jet injection system |
US9211378B2 (en) | 2010-10-22 | 2015-12-15 | Cequr Sa | Methods and systems for dosing a medicament |
CN103328499A (en) | 2010-11-01 | 2013-09-25 | 悉尼科技大学 | Immune-modulating agents and uses therefor |
GB201021881D0 (en) * | 2010-12-23 | 2011-02-02 | Profibrix Bv | Powder delivery device |
US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
US8430839B2 (en) | 2011-04-19 | 2013-04-30 | Palo Alto Research Center Incorporated | Drug delivery devices and methods with collimated gas stream and drug reservoir |
US8388569B2 (en) | 2011-04-19 | 2013-03-05 | Xerox Corporation | Delivery devices and methods with collimated gas stream and particle source |
US8486002B2 (en) | 2011-04-19 | 2013-07-16 | Palo Alto Research Center Incorporated | Drug delivery devices and methods with collimated gas stream and release-activatable tape |
WO2013037804A1 (en) | 2011-09-12 | 2013-03-21 | Laboratorios Del Dr. Esteve, S.A. | Method for monitoring cytotoxic t lymphocyte (ctl) responses by a delayed-type hypersensitivity reaction using defined ctl viral epitopes |
JP2014533953A (en) | 2011-11-17 | 2014-12-18 | ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ | Therapeutic RNA switch compositions and methods of use |
US20140058319A1 (en) * | 2012-03-20 | 2014-02-27 | Glucago Llc | Compact Device For Rapidly Mixing and Delivering Substances To a Patient |
US8992469B2 (en) | 2012-06-26 | 2015-03-31 | Glucago Llc | Reconstitution device |
US9125995B2 (en) | 2012-12-05 | 2015-09-08 | Glucago Llc | Reconstitution devices |
US9345487B2 (en) | 2013-02-05 | 2016-05-24 | Path Scientific, Llc | Precision bone drill and method of use |
EP2851086A1 (en) | 2013-09-20 | 2015-03-25 | Sanofi | Serpins: methods of therapeutic ß-cell regeneration and function |
EP2769732A1 (en) | 2013-02-22 | 2014-08-27 | Sanofi | Serpins: methods of therapeutic beta-cell regeneration and function |
US20160002316A1 (en) | 2013-02-22 | 2016-01-07 | Joslin Diabetes Center | Serpins: methods of therapeutic beta-cell regeneration and function |
EP2968886A1 (en) | 2013-03-14 | 2016-01-20 | Hallux, Inc. | Method of treating infections, diseases or disorders of nail unit |
US9808579B2 (en) * | 2013-05-08 | 2017-11-07 | Elwha Llc | Needleless injector systems, and related methods and components |
US10279113B2 (en) * | 2013-05-17 | 2019-05-07 | Socpra Sciences Et Genie S.E.C. | Needleless syringe and method for delivering therapeutic particles |
AU2015222937B2 (en) * | 2014-02-26 | 2017-03-30 | Powder Pharmaceuticals Incorporated | Device for delivering particles |
WO2015171964A1 (en) * | 2014-05-07 | 2015-11-12 | Sri International | Needle free injection device |
US9737251B2 (en) | 2014-05-28 | 2017-08-22 | Verily Life Sciences Llc | Needle-free blood draw |
EP2959931A1 (en) * | 2014-06-24 | 2015-12-30 | LTS LOHMANN Therapie-Systeme AG | Needle-free injection device |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
EP3011988A1 (en) * | 2014-10-22 | 2016-04-27 | LTS LOHMANN Therapie-Systeme AG | Needle-free injection device with a gel and a membrane |
WO2016077382A2 (en) | 2014-11-11 | 2016-05-19 | Massachusetts Eye & Ear Infirmary | Conjunctivitis vaccines |
WO2016100401A1 (en) | 2014-12-15 | 2016-06-23 | Dicerna Pharmaceuticals, Inc. | Ligand-modified double-stranded nucleic acids |
EP3277815B1 (en) | 2015-04-03 | 2021-09-22 | University of Massachusetts | Oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders |
CA2980337A1 (en) | 2015-04-03 | 2016-10-06 | University Of Massachusetts | Oligonucleotide compounds for targeting huntingtin mrna |
EP3292206B8 (en) | 2015-05-07 | 2022-02-09 | Takeda Pharmaceutical Company Limited | Glucocerebrosidase gene therapy for parkinson's disease |
KR20240042548A (en) | 2015-06-03 | 2024-04-02 | 인타르시아 세라퓨틱스 인코포레이티드 | Implant placement and removal systems |
US20160361240A1 (en) | 2015-06-11 | 2016-12-15 | The Procter & Gamble Company | Apparatus and methods for modifying keratinous surfaces |
CA2995110A1 (en) | 2015-08-14 | 2017-02-23 | University Of Massachusetts | Bioactive conjugates for oligonucleotide delivery |
JP2018535655A (en) | 2015-09-29 | 2018-12-06 | アムジエン・インコーポレーテツド | ASGR inhibitor |
CA3005878A1 (en) | 2015-11-19 | 2017-05-26 | The Brigham And Women's Hospital, Inc. | Lymphocyte antigen cd5-like (cd5l)-interleukin 12b (p40) heterodimers in immunity |
US11027071B2 (en) * | 2015-12-28 | 2021-06-08 | Inovio Pharmaceuticals, Inc. | Intradermal jet injection electroporation device |
CA3011894A1 (en) | 2016-01-31 | 2017-08-03 | University Of Massachusetts | Branched oligonucleotides |
MA53353A (en) | 2016-05-16 | 2021-06-09 | Intarcia Therapeutics Inc | GLUCAGON RECEPTOR SELECTIVE POLYPEPTIDES AND METHODS FOR THEIR USE |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
CA3033368A1 (en) | 2016-08-12 | 2018-02-15 | University Of Massachusetts | Conjugated oligonucleotides |
US10443055B2 (en) | 2016-12-22 | 2019-10-15 | Beth Israel Deaconess Medical Center | Compounds that target MYC microRNA responsive elements for the treatment of MYC-associated cancer |
EP3565580B1 (en) | 2017-01-03 | 2024-03-06 | i2o Therapeutics, Inc. | Continuous administration of exenatide and co-adminstration of acetaminophen, ethinylestradiol or levonorgestrel |
EP3664834A1 (en) | 2017-08-11 | 2020-06-17 | Dana Farber Cancer Institute, Inc. | Use of a botulinum toxin agent for treating plasma cell disorders |
US11821003B2 (en) | 2017-08-14 | 2023-11-21 | Sanford Burnham Prebys Medical Discovery Institute | Cardiogenic mesoderm formation regulators |
EP3703669A4 (en) | 2017-11-01 | 2021-11-10 | Dana-Farber Cancer Institute, Inc. | Methods of treating cancers |
CN112424352A (en) | 2018-05-11 | 2021-02-26 | 阿尔法阿诺麦里克公司 | Oligonucleotide conjugates comprising 7 '-5' -alpha-anomeric bicyclic sugar nucleosides |
CN108553748A (en) * | 2018-05-11 | 2018-09-21 | 江秀秀 | Internal various kinds of cell is implanted into instrument under B ultrasound monitoring |
USD933219S1 (en) | 2018-07-13 | 2021-10-12 | Intarcia Therapeutics, Inc. | Implant removal tool and assembly |
JP2021533762A (en) | 2018-08-10 | 2021-12-09 | ユニバーシティ・オブ・マサチューセッツUniversity Of Massachusetts | Modified oligonucleotides that target SNPs |
EP3843845A4 (en) | 2018-08-29 | 2022-05-11 | University Of Massachusetts | Inhibition of protein kinases to treat friedreich ataxia |
KR102199724B1 (en) * | 2018-10-05 | 2021-01-07 | 주식회사 피테크 | Painless injection device without needle |
BR112021012172A2 (en) | 2018-12-12 | 2021-08-31 | Kite Pharma, Inc. | CHIMERIC AND T-CELL ANTIGEN RECEPTORS AND METHODS OF USE |
CN114072501A (en) | 2019-05-06 | 2022-02-18 | 马萨诸塞大学 | anti-C9 ORF72 oligonucleotides and related methods |
CN110038212A (en) * | 2019-05-29 | 2019-07-23 | 徐小棠 | A kind of Respiratory Medicine nursing administration multi-purpose device |
CN110180051B (en) * | 2019-07-13 | 2021-04-02 | 河南省中医院(河南中医药大学第二附属医院) | Belt cleaning device is used in obstetrical department's nursing |
GB202105455D0 (en) | 2021-04-16 | 2021-06-02 | Ucl Business Ltd | Composition |
EP4359539A1 (en) | 2021-06-23 | 2024-05-01 | University Of Massachusetts | Optimized anti-flt1 oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders |
AU2022299660A1 (en) * | 2021-06-24 | 2024-01-18 | Avectas Limited | Spray nozzle |
GB202112471D0 (en) | 2021-09-01 | 2021-10-13 | King S College London | Microna systems |
WO2024052732A1 (en) * | 2022-09-07 | 2024-03-14 | Particle Vaccine Canada Ltd. | Method and apparatus for epidermal delivery of powdered medicaments |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3736933A (en) * | 1970-12-02 | 1973-06-05 | B Szabo | Burstable seamed hypodermic applicators |
US3788315A (en) * | 1971-04-20 | 1974-01-29 | S Laurens | Disposable cutaneous transjector |
FR2360031A1 (en) * | 1976-07-27 | 1978-02-24 | Klein Max | Silenced gas spray for examination of ear - has supple tube attached to an aerosol and filled with foam which allows laminar flow of gas and reduces noise |
GB2206794A (en) * | 1987-07-14 | 1989-01-18 | Richard Kiteley Power | Syringe |
EP0371838A1 (en) * | 1988-11-03 | 1990-06-06 | Tino Dalto | Syringe guide with regulation of penetration depth into the skin |
EP0406778A1 (en) * | 1989-07-05 | 1991-01-09 | Erdélyi Dr. Dipl.-Ing. Gyula | Needleless inoculator |
WO1992004439A1 (en) * | 1990-08-30 | 1992-03-19 | Brian John Bellhouse | Ballistic apparatus |
Family Cites Families (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE170094C (en) | ||||
US1300654A (en) | 1919-01-30 | 1919-04-15 | William H Rose | Dry-spraying machine. |
US2151418A (en) * | 1937-05-12 | 1939-03-21 | Scott & Bowne | Powder applicator |
US2147158A (en) | 1937-09-28 | 1939-02-14 | Goldenthal Philip | Powder insufflator |
US2307986A (en) | 1940-02-15 | 1943-01-12 | Bolte | Insufflator |
US2605763A (en) * | 1948-01-31 | 1952-08-05 | Becton Dickinson Co | Injection device |
GB677523A (en) * | 1948-04-13 | 1952-08-20 | Becton Dickinson Co | Discharge structure for hypodermic injection device |
US2478715A (en) | 1948-07-14 | 1949-08-09 | Vilbiss Co | Powder blower |
US2594093A (en) | 1949-02-05 | 1952-04-22 | Armour & Co | Powder container |
US2470298A (en) | 1949-02-07 | 1949-05-17 | Abbott Lab | Powdered medicine dispenser |
DE1047385B (en) * | 1952-03-08 | 1958-12-24 | Armour & Co | Powder atomizer with an exchangeable powder container |
US3216562A (en) | 1963-06-13 | 1965-11-09 | Driaire Inc | Easy-open capsule |
IL28680A (en) | 1966-12-16 | 1971-12-29 | American Home Prod | Stabilized aqueous suspensions of benzathine penicillin |
US3674028A (en) * | 1969-06-04 | 1972-07-04 | Ims Ltd | Multi-mix |
US3914573A (en) * | 1971-05-17 | 1975-10-21 | Geotel Inc | Coating heat softened particles by projection in a plasma stream of Mach 1 to Mach 3 velocity |
US3853125A (en) * | 1971-10-05 | 1974-12-10 | W Clark | Disposable needleless injector |
US3782380A (en) * | 1973-01-04 | 1974-01-01 | Gaast H V D | Medicament injecting device |
US4069819A (en) * | 1973-04-13 | 1978-01-24 | Societa Farmaceutici S.P.A. | Inhalation device |
US3946732A (en) * | 1973-08-08 | 1976-03-30 | Ampoules, Inc. | Two-chamber mixing syringe |
US3967761A (en) | 1974-04-08 | 1976-07-06 | Southwest Research Institute | System for injecting particulate material into the combustion chamber of a repetitive combustion coating apparatus |
US3952741A (en) * | 1975-01-09 | 1976-04-27 | Bend Research Inc. | Controlled release delivery system by an osmotic bursting mechanism |
US3982605A (en) * | 1975-05-05 | 1976-09-28 | The Carborundum Company | Nozzle noise silencer |
JPS602489B2 (en) * | 1977-05-02 | 1985-01-22 | 株式会社豊田中央研究所 | Pressure fluid release device for low noise |
AU521982B2 (en) * | 1978-06-16 | 1982-05-13 | Phares Pharmaceutical Research N.V. | Pharmaceuticals with urea incuusion compounds |
US4226236A (en) * | 1979-05-07 | 1980-10-07 | Abbott Laboratories | Prefilled, vented two-compartment syringe |
FI79651C (en) | 1982-10-08 | 1990-02-12 | Glaxo Group Ltd | Dosing device for medicine |
US4778054A (en) | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
US4515586A (en) | 1982-11-30 | 1985-05-07 | Abbott Laboratories | Powder syringe mixing system |
US4652261A (en) * | 1984-06-22 | 1987-03-24 | Regents Of The University Of Minnesota | Drug-injection animal capture collar |
US4945050A (en) * | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
US5036006A (en) * | 1984-11-13 | 1991-07-30 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
US5100792A (en) * | 1984-11-13 | 1992-03-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues |
US4596556A (en) * | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
US4811731A (en) | 1985-07-30 | 1989-03-14 | Glaxo Group Limited | Devices for administering medicaments to patients |
DK179286D0 (en) | 1986-04-18 | 1986-04-18 | Nordisk Gentofte | INSULIN PREPARATION |
USRE33801E (en) | 1986-05-09 | 1992-01-21 | Dentsply Research & Development Corp. | Mixing and discharge capsule |
US5120657A (en) | 1986-12-05 | 1992-06-09 | Agracetus, Inc. | Apparatus for genetic transformation |
IN170021B (en) * | 1987-05-26 | 1992-01-25 | Deita Freyberg Gmbh | |
US4853229A (en) * | 1987-10-26 | 1989-08-01 | Alza Corporation | Method for adminstering tiny pills |
US5179022A (en) * | 1988-02-29 | 1993-01-12 | E. I. Du Pont De Nemours & Co. | Biolistic apparatus for delivering substances into cells and tissues in a non-lethal manner |
BR8801952A (en) * | 1988-04-22 | 1989-11-14 | Sergio Landau | DISPOSABLE CAPSULE, NOT RE-USABLE, CONTAINING INDIVIDUAL DOSE OF VACCINE TO BE HYPODERMICALLY INJECTED, WITHOUT NEEDLE, WITH PRESSURE INJECTOR |
JPH04504858A (en) * | 1989-04-20 | 1992-08-27 | マウント シナイ スクール オブ メディスン オブ ザ シティー ユニバーシティー オブ ニューヨーク | Liver-specific insulin analogs |
US5239991A (en) | 1989-06-21 | 1993-08-31 | Fisons Plc | Disposable powder medicament inhalation device with peel-off cover |
GB8918879D0 (en) * | 1989-08-18 | 1989-09-27 | Danbiosyst Uk | Pharmaceutical compositions |
US5064413A (en) * | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
AU7558991A (en) * | 1990-03-15 | 1991-10-10 | United States Of America, As Represented By The Secretary Of The Army, The | Chemotherapeutic treatment of bacterial infections with an antibiotic encapsulated within a biodegradable polymeric matrix |
US5062830A (en) * | 1990-04-04 | 1991-11-05 | Derata Corporation | Dry disposable nozzle assembly for medical jet injector |
GB9011588D0 (en) * | 1990-05-24 | 1990-07-11 | Wellcome Found | Prostaglandin analogues for use in medicine |
US5204253A (en) * | 1990-05-29 | 1993-04-20 | E. I. Du Pont De Nemours And Company | Method and apparatus for introducing biological substances into living cells |
US5149655A (en) * | 1990-06-21 | 1992-09-22 | Agracetus, Inc. | Apparatus for genetic transformation |
IT1243344B (en) | 1990-07-16 | 1994-06-10 | Promo Pack Sa | MULTI-DOSE INHALER FOR POWDER MEDICATIONS |
GB9016789D0 (en) * | 1990-07-31 | 1990-09-12 | Lilly Industries Ltd | Medicament administering devices |
US5042472A (en) | 1990-10-15 | 1991-08-27 | Merck & Co., Inc. | Powder inhaler device |
US5188615A (en) | 1990-11-19 | 1993-02-23 | Habley Medical Technology Corp. | Mixing vial |
US5046618A (en) | 1990-11-19 | 1991-09-10 | R. P. Scherer Corporation | Child-resistant blister pack |
DK288590D0 (en) * | 1990-12-04 | 1990-12-04 | Michael Morris | MIXTURE / SOLUTION SPRAY FOR CYTOSTATICS FOR MEDICAL TREATMENT OF CANCER PATIENTS |
GB9027422D0 (en) * | 1990-12-18 | 1991-02-06 | Scras | Osmotically driven infusion device |
US5360410A (en) | 1991-01-16 | 1994-11-01 | Senetek Plc | Safety syringe for mixing two-component medicaments |
GB9100950D0 (en) * | 1991-01-16 | 1991-02-27 | Dunne Miller Weston Ltd | Metered dose atomising and delivery device |
US5492112A (en) | 1991-05-20 | 1996-02-20 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
US5102388A (en) | 1991-07-15 | 1992-04-07 | Richmond John E | Sequential delivery syringe |
GB9118204D0 (en) * | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
EP0558879B1 (en) | 1992-03-04 | 1997-05-14 | Astra Aktiebolag | Disposable inhaler |
JP3166123B2 (en) | 1992-09-09 | 2001-05-14 | フアイソンズ・ピーエルシー | Drug packaging |
TW360548B (en) * | 1993-04-08 | 1999-06-11 | Powderject Res Ltd | Products for therapeutic use |
US5349947A (en) * | 1993-07-15 | 1994-09-27 | Newhouse Michael T | Dry powder inhaler and process that explosively discharges a dose of powder and gas from a soft plastic pillow |
US5415162A (en) | 1994-01-18 | 1995-05-16 | Glaxo Inc. | Multi-dose dry powder inhalation device |
NZ279995A (en) | 1994-01-21 | 1998-04-27 | Powderject Vaccines Inc | Gas driven gene delivery instrument with a conical exit nozzle and a cartridge with an arcuate, linear passage |
US5483954A (en) | 1994-06-10 | 1996-01-16 | Mecikalski; Mark B. | Inhaler and medicated package |
JP3320261B2 (en) * | 1995-06-01 | 2002-09-03 | 株式会社ユニシアジェックス | Inhaler type dispenser |
-
1994
- 1994-04-07 TW TW086113385A patent/TW360548B/en not_active IP Right Cessation
- 1994-04-07 TW TW083103025A patent/TW404844B/en not_active IP Right Cessation
- 1994-04-08 JP JP52287794A patent/JP3260375B2/en not_active Expired - Lifetime
- 1994-04-08 AU AU64351/94A patent/AU674742B2/en not_active Expired
- 1994-04-08 DE DE69434760T patent/DE69434760T2/en not_active Expired - Lifetime
- 1994-04-08 PL PL94311005A patent/PL174974B1/en unknown
- 1994-04-08 EP EP05028150.0A patent/EP1637173B1/en not_active Expired - Lifetime
- 1994-04-08 HU HU9802714A patent/HU228144B1/en unknown
- 1994-04-08 AT AT96109925T patent/ATE329006T1/en active
- 1994-04-08 BR BR9406455A patent/BR9406455A/en not_active Application Discontinuation
- 1994-04-08 DK DK94912038.0T patent/DK0693119T3/en active
- 1994-04-08 ES ES94912038T patent/ES2098131T3/en not_active Expired - Lifetime
- 1994-04-08 EP EP99113305A patent/EP0951917A3/en not_active Withdrawn
- 1994-04-08 DE DE69401651T patent/DE69401651T2/en not_active Expired - Lifetime
- 1994-04-08 HU HU9502911A patent/HU216308B/en unknown
- 1994-04-08 KR KR1019950704408A patent/KR100332147B1/en not_active IP Right Cessation
- 1994-04-08 UA UA95094347A patent/UA41360C2/en unknown
- 1994-04-08 EP EP96109925A patent/EP0734737B1/en not_active Expired - Lifetime
- 1994-04-08 DK DK96109925T patent/DK0734737T3/en active
- 1994-04-08 ES ES96109925T patent/ES2267106T3/en not_active Expired - Lifetime
- 1994-04-08 AT AT94912038T patent/ATE148497T1/en active
- 1994-04-08 EP EP94912038A patent/EP0693119B1/en not_active Expired - Lifetime
- 1994-04-08 CN CN94191721A patent/CN1109102C/en not_active Expired - Lifetime
- 1994-04-08 SI SI9430045T patent/SI0693119T1/en unknown
- 1994-04-08 PT PT96109925T patent/PT734737E/en unknown
- 1994-04-08 RU RU95119388A patent/RU2129021C1/en active
- 1994-04-08 WO PCT/GB1994/000753 patent/WO1994024263A1/en active IP Right Grant
- 1994-04-08 CA CA002159452A patent/CA2159452C/en not_active Expired - Lifetime
- 1994-04-08 CZ CZ19952608A patent/CZ290476B6/en not_active IP Right Cessation
- 1994-04-08 SI SI9430481T patent/SI0734737T1/en unknown
- 1994-04-08 TJ TJ95000044A patent/TJ248B/en unknown
- 1994-04-08 RO RO95-01747A patent/RO118569B1/en unknown
- 1994-04-08 NZ NZ263606A patent/NZ263606A/en not_active IP Right Cessation
- 1994-04-08 SK SK1248-95A patent/SK283855B6/en not_active IP Right Cessation
-
1995
- 1995-06-07 US US08/474,367 patent/US5630796A/en not_active Expired - Lifetime
- 1995-10-04 BG BG100047A patent/BG61993B1/en unknown
- 1995-10-06 FI FI954788A patent/FI120671B/en not_active IP Right Cessation
- 1995-10-06 OA OA60719A patent/OA10234A/en unknown
- 1995-10-06 NO NO19953994A patent/NO314570B1/en not_active IP Right Cessation
-
1997
- 1997-03-17 LV LVP-97-41A patent/LV11833B/en unknown
- 1997-03-26 GR GR970400626T patent/GR3022939T3/en unknown
- 1997-10-09 HK HK97101908A patent/HK1000351A1/en not_active IP Right Cessation
- 1997-12-05 US US08/986,124 patent/US6168587B1/en not_active Expired - Lifetime
-
1999
- 1999-02-10 US US09/248,743 patent/US6881200B2/en not_active Expired - Lifetime
-
2001
- 2001-09-27 JP JP2001298589A patent/JP2002179557A/en active Pending
-
2002
- 2002-12-09 US US10/314,336 patent/US7618394B2/en not_active Expired - Fee Related
-
2006
- 2006-07-12 JP JP2006192130A patent/JP4430636B2/en not_active Expired - Lifetime
- 2006-11-06 JP JP2006301005A patent/JP2007051160A/en active Pending
-
2007
- 2007-08-31 US US11/848,432 patent/US7942846B2/en not_active Expired - Fee Related
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3736933A (en) * | 1970-12-02 | 1973-06-05 | B Szabo | Burstable seamed hypodermic applicators |
US3788315A (en) * | 1971-04-20 | 1974-01-29 | S Laurens | Disposable cutaneous transjector |
FR2360031A1 (en) * | 1976-07-27 | 1978-02-24 | Klein Max | Silenced gas spray for examination of ear - has supple tube attached to an aerosol and filled with foam which allows laminar flow of gas and reduces noise |
GB2206794A (en) * | 1987-07-14 | 1989-01-18 | Richard Kiteley Power | Syringe |
EP0371838A1 (en) * | 1988-11-03 | 1990-06-06 | Tino Dalto | Syringe guide with regulation of penetration depth into the skin |
EP0406778A1 (en) * | 1989-07-05 | 1991-01-09 | Erdélyi Dr. Dipl.-Ing. Gyula | Needleless inoculator |
WO1992004439A1 (en) * | 1990-08-30 | 1992-03-19 | Brian John Bellhouse | Ballistic apparatus |
Non-Patent Citations (2)
Title |
---|
J.H. OARD ET AL.: "TRANSIENT GENE EXPRESSION IN MAIZE, RICE AND WHEAT CELLS USING AN AIRGUN APPARATUS", PLANT PHYSIOLOGY, 1990, BETHESDA, MD, pages 334 - 339 * |
R. SANDERS WILLIAMS ET AL.: "INTRODUCTION OF FOREIGN GENES INTO TISSUES OF LIVING MICE BY DNA-COATED MICROPROJECTILES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 88, no. 7, April 1991 (1991-04-01), WASHINGTON US * |
Cited By (133)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5584807A (en) * | 1994-01-21 | 1996-12-17 | Agracetus, Inc. | Gas driven gene delivery instrument |
US5865796A (en) * | 1994-01-21 | 1999-02-02 | Powderject Vaccines, Inc | Gas driven gene delivery instrument |
EP1138337A2 (en) * | 1994-08-04 | 2001-10-04 | Quadrant Holdings Cambridge Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
US6586006B2 (en) | 1994-08-04 | 2003-07-01 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
EP1138337A3 (en) * | 1994-08-04 | 2003-03-26 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
US6893657B2 (en) | 1994-12-02 | 2005-05-17 | Quadrant Drug Delivery Ltd. | Solid dose delivery vehicle and methods of making same |
US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
US6685669B2 (en) | 1994-12-23 | 2004-02-03 | Powderject Research Limited | Particle delivery |
WO1996020022A1 (en) * | 1994-12-23 | 1996-07-04 | Powderject Research Limited | Particle delivery |
US6592545B1 (en) | 1994-12-23 | 2003-07-15 | Powderject Research Limited | Particle delivery |
WO1996025190A1 (en) * | 1995-02-14 | 1996-08-22 | Powderject Research Limited | Trans-mucosal particle delivery |
US6010478A (en) * | 1995-02-14 | 2000-01-04 | Powderject Research Limited | Trans-mucosal particle delivery |
EP0826059A1 (en) * | 1995-05-04 | 1998-03-04 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus and method for delivering a nucleotide into cell nuclei |
EP0826059A4 (en) * | 1995-05-04 | 1998-07-01 | Univ Leland Stanford Junior | Apparatus and method for delivering a nucleotide into cell nuclei |
US7223739B1 (en) | 1995-06-07 | 2007-05-29 | Powderject Vaccines, Inc. | Adjuvanted genetic vaccines |
US7699801B2 (en) | 1995-06-07 | 2010-04-20 | Powderject Vaccines, Inc. | Advanced genetic vaccines |
EP0757202A3 (en) * | 1995-08-02 | 1997-09-03 | Boc Group Plc | Gas delivery system |
US5845811A (en) * | 1995-08-02 | 1998-12-08 | The Boc Group Plc | Gas capsule |
US5954232A (en) * | 1995-08-02 | 1999-09-21 | The Boc Group Plc | Gas delivery system |
EP0757203A3 (en) * | 1995-08-02 | 1997-09-03 | Boc Group Plc | Gas capsule |
EP0757203A2 (en) * | 1995-08-02 | 1997-02-05 | The BOC Group plc | Gas capsule |
EP0757202A2 (en) | 1995-08-02 | 1997-02-05 | The BOC Group plc | Gas delivery system |
US6013050A (en) * | 1995-10-20 | 2000-01-11 | Powderject Research Limited | Particle delivery |
WO1997034652A1 (en) * | 1996-03-19 | 1997-09-25 | Powderject Research Limited | Needleless syringe with therapeutic agent particles entrained in supersonic gas flow |
US6893664B1 (en) | 1996-06-17 | 2005-05-17 | Powderject Research Limited | Particle delivery techniques |
US7164133B2 (en) | 1996-07-01 | 2007-01-16 | Pharmacia Ab | Delivery device and method for its operation |
US6858846B2 (en) | 1996-07-01 | 2005-02-22 | Pharmacia Ab | Delivery device and method for its operation |
US6221051B1 (en) | 1996-07-01 | 2001-04-24 | Pharmacia Ab | Delivery device and method for its operation |
EP0821195A2 (en) | 1996-07-24 | 1998-01-28 | The BOC Group plc | Gas capsule and gas delivery system |
US6468782B1 (en) | 1996-12-05 | 2002-10-22 | Quadrant Healthcare (Uk) Limited | Methods of preserving prokaryotic cells and compositions obtained thereby |
WO1998031409A3 (en) * | 1997-01-17 | 1998-11-12 | Boehringer Mannheim Gmbh | Hypodermic injection system |
US6258063B1 (en) | 1997-01-17 | 2001-07-10 | Roche Diagnostics Gmbh | Hypodermic injection system |
WO1998031409A2 (en) * | 1997-01-17 | 1998-07-23 | Roche Diagnostics Gmbh | Hypodermic injection system |
WO1999001169A1 (en) * | 1997-07-04 | 1999-01-14 | Powderject Research Limited | Syringe and capsule therefor |
EP0888791A1 (en) * | 1997-07-04 | 1999-01-07 | PowderJect Research Limited | Syringe and drug capsule therefor |
EP0888790A1 (en) * | 1997-07-04 | 1999-01-07 | PowderJect Research Limited | Drug particle delivery device |
US7182748B1 (en) | 1997-07-04 | 2007-02-27 | Powderject Research Limited | Syringe and capsule therefor |
WO1999001168A1 (en) * | 1997-07-04 | 1999-01-14 | Powderject Research Limited | Drug particle delivery |
US6475181B1 (en) * | 1997-07-04 | 2002-11-05 | Powderject Research Limited | Drug particle delivery |
US6074360A (en) * | 1997-07-21 | 2000-06-13 | Boehringer Mannheim Gmbh | Electromagnetic transdermal injection device and methods related thereto |
WO1999004838A1 (en) | 1997-07-21 | 1999-02-04 | Roche Diagnostics Gmbh | Electromagnetic transdermal injection device and methods related thereto |
US6171276B1 (en) | 1997-08-06 | 2001-01-09 | Pharmacia & Upjohn Ab | Automated delivery device and method for its operation |
US6547755B1 (en) | 1997-08-06 | 2003-04-15 | Pharmacia Ab | Automated delivery device and method for its operation |
US9554993B2 (en) | 1997-09-29 | 2017-01-31 | Novartis Ag | Pulmonary delivery particles comprising an active agent |
WO1999026662A1 (en) * | 1997-11-20 | 1999-06-03 | Aventis Pasteur | A method for in vivo dna delivery using a needle free apparatus |
AU753976B2 (en) * | 1997-11-20 | 2002-10-31 | Aventis Pasteur | A method for in vivo DNA delivery using a needle free apparatus |
WO1999027961A1 (en) * | 1997-12-02 | 1999-06-10 | Powderject Vaccines, Inc. | Transdermal delivery of particulate vaccine compositions |
WO1999031262A2 (en) * | 1997-12-16 | 1999-06-24 | Valentis, Inc. | Needle-free injection of formulated nucleic acid molecules |
WO1999031262A3 (en) * | 1997-12-16 | 1999-09-10 | Valentis Inc | Needle-free injection of formulated nucleic acid molecules |
EP0934753A2 (en) | 1998-02-05 | 1999-08-11 | The BOC Group plc | Needleless medical device for delivering of terapeutic agent |
EP0934754A2 (en) | 1998-02-05 | 1999-08-11 | The BOC Group plc | Needleless medical device for delivering of therapeutic agent |
US6693087B1 (en) | 1998-08-20 | 2004-02-17 | Aventis Pasteur Limited | Nucleic acid molecules encoding POMP91A protein of Chlamydia |
US6521745B1 (en) | 1998-08-20 | 2003-02-18 | Aventis Pasteur Limited | Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia |
US7166289B2 (en) | 1998-08-20 | 2007-01-23 | Sanofi Pasteur Limited | Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia |
US6686339B1 (en) | 1998-08-20 | 2004-02-03 | Aventis Pasteur Limited | Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia |
WO2000013573A1 (en) | 1998-09-04 | 2000-03-16 | Powderject Research Limited | Monitoring methods using particle delivery methods |
US6482604B2 (en) | 1998-09-04 | 2002-11-19 | Powderject Research Limited | Non-or minimally invasive monitoring methods using particle delivery methods |
US6207400B1 (en) | 1998-09-04 | 2001-03-27 | Powderject Research Limited | Non- or minimally invasive monitoring methods using particle delivery methods |
US6602678B2 (en) | 1998-09-04 | 2003-08-05 | Powderject Research Limited | Non- or minimally invasive monitoring methods |
AU765763B2 (en) * | 1998-09-04 | 2003-09-25 | Powderject Research Limited | Monitoring methods using particle delivery methods |
WO2000019982A1 (en) * | 1998-10-01 | 2000-04-13 | Powderject Research Limited | Spray coated microparticles for use in needleless syringes |
US6613360B1 (en) | 1998-10-01 | 2003-09-02 | Powderject Research Limited | Particle formation |
EP2100960A2 (en) | 1998-10-30 | 2009-09-16 | Sanofi Pasteur | Specific polypeptides and nucleic acids of pathogenic strains of the Neisseria genus |
US6881723B1 (en) | 1998-11-05 | 2005-04-19 | Powderject Vaccines, Inc. | Nucleic acid constructs |
US6135170A (en) * | 1998-11-25 | 2000-10-24 | The Boc Group Plc | Filling containers with gas |
US7022313B2 (en) | 1999-02-03 | 2006-04-04 | Powderject Research Ltd. | Hydrogel particle formulation |
US7022320B1 (en) | 1999-02-09 | 2006-04-04 | Powderject Vaccines, Inc. | Mycobacterium tuberculosis immunization |
US7013617B2 (en) | 1999-04-01 | 2006-03-21 | The Boc Group, Plc | Method of filling and sealing |
US7666844B2 (en) | 1999-04-16 | 2010-02-23 | Novo Nordisk A/S | Dry mouldable drug formulation |
US8518430B2 (en) | 1999-04-16 | 2013-08-27 | Novo Nordisk A/S | Dry mouldable drug formulation |
US8084053B2 (en) | 1999-04-16 | 2011-12-27 | Novo Nordisk A/S | Dry mouldable drug formulation |
WO2001005451A1 (en) * | 1999-07-16 | 2001-01-25 | Snpe | Needleless syringe operating with an impact wave generator through a wall |
US7261702B1 (en) | 1999-07-16 | 2007-08-28 | Crossject | Needleless syringe operating with an impact wave generator through a wall |
FR2796290A1 (en) * | 1999-07-16 | 2001-01-19 | Cross Site Technologies | NEEDLELESS SYRINGE OPERATING WITH A SHOCK WAVE GENERATOR THROUGH A WALL |
US6811783B1 (en) | 1999-09-07 | 2004-11-02 | Aventis Pasteur Limited | Immunogenic compositions for protection against chlamydial infection |
EP1964573A2 (en) | 1999-10-22 | 2008-09-03 | Aventis Pasteur Limited | Method of inducing and/or enhancing an immune response to tumor antigens |
US7196066B1 (en) | 1999-11-03 | 2007-03-27 | Powderject Vaccines, Inc. | DNA-vaccines based on constructs derived from the genomes of human and animal pathogens |
WO2001041840A1 (en) * | 1999-12-08 | 2001-06-14 | Crossject | Needless syringe provided with an ejection tube with a constant cross-section |
FR2802102A1 (en) | 1999-12-08 | 2001-06-15 | Poudres & Explosifs Ste Nale | NEEDLELESS SYRINGE WITH EJECTION TUBE WITH CONSTANT SECTION |
US6913593B1 (en) | 1999-12-08 | 2005-07-05 | Crossject | Needleless syringe which functions with the active agent being driven by a shocktube effect |
US6837866B1 (en) | 1999-12-08 | 2005-01-04 | Crossject | Needleless syringe provided with an ejection tube with a constant cross-section |
WO2001047585A1 (en) * | 1999-12-27 | 2001-07-05 | Crossject | Needleless syringe operating by impact tube effect, with prior lateral retention of active principle |
US6911015B2 (en) | 1999-12-27 | 2005-06-28 | Crossject | Needleless syringe functioning by shock-tube effect, with prior lateral retention of the active principle |
FR2802820A1 (en) * | 1999-12-27 | 2001-06-29 | Poudres & Explosifs Ste Nale | Needleless syringe has pyrotechnic gas generator to eject solid particles by tube shock effect |
WO2001056637A1 (en) | 2000-02-02 | 2001-08-09 | Crossject | Needleless syringe provided with an inner seal containing the active principle |
US6835187B2 (en) | 2000-02-02 | 2004-12-28 | Crossject | Needleless syringe provided with an inner seal containing the active principle |
FR2804329A1 (en) | 2000-02-02 | 2001-08-03 | Poudres & Explosifs Ste Nale | SYRINGE WITHOUT NEEDLE PROVIDED WITH A LID CONTAINING THE ACTIVE INGREDIENT |
US6932789B2 (en) | 2000-03-03 | 2005-08-23 | Boehringer Ingelheim International Gmbh | Needle-less injector of miniature type |
EP1792995A2 (en) | 2000-05-08 | 2007-06-06 | Sanofi Pasteur Limited | Chlamydia secretory locus orf and uses thereof |
EP1741782A2 (en) | 2000-05-10 | 2007-01-10 | Sanofi Pasteur Limited | Immunogenic polypeptides encoded by MAGE minigenes and uses thereof |
US9439862B2 (en) | 2000-05-10 | 2016-09-13 | Novartis Ag | Phospholipid-based powders for drug delivery |
US8877162B2 (en) | 2000-05-10 | 2014-11-04 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery |
WO2002030275A1 (en) | 2000-10-13 | 2002-04-18 | Precisense A/S | Optical sensor for in situ measurement of analytes |
US6671527B2 (en) | 2000-10-13 | 2003-12-30 | Precisense A/S | Optical sensor for in situ measurement of analytes |
WO2003004055A2 (en) | 2000-11-27 | 2003-01-16 | Powderject Vaccines, Inc. | Nucleic acid adjuvants |
USRE43824E1 (en) | 2001-01-11 | 2012-11-20 | Powder Pharmaceuticals Inc. | Needleless syringe |
US7909793B2 (en) | 2001-07-26 | 2011-03-22 | Powderject Research Limited | Silencing device and method for needleless syringe |
EP1637174A2 (en) * | 2001-07-26 | 2006-03-22 | PowderJect Research Limited | Silencing device and method of operating a needleless syringe |
EP1847286A3 (en) * | 2001-07-26 | 2008-01-09 | PowderJect Research Limited | Silencing device and method of operating a needleless syringe |
EP1847286A2 (en) | 2001-07-26 | 2007-10-24 | PowderJect Research Limited | Silencing device and method of operating a needleless syringe |
EP1637174A3 (en) * | 2001-07-26 | 2006-05-03 | PowderJect Research Limited | Silencing device and method of operating a needleless syringe |
AU2002321403B2 (en) * | 2001-07-26 | 2007-10-04 | Powderject Research Limited | Silencing device and method for needleless syringe |
WO2003011380A2 (en) | 2001-07-26 | 2003-02-13 | Powderject Research Limited | Silencing device and method for needleless syringe |
WO2003011380A3 (en) * | 2001-07-26 | 2003-05-30 | Powderject Res Ltd | Silencing device and method for needleless syringe |
WO2003052125A1 (en) | 2001-12-17 | 2003-06-26 | Powderject Research Limited | Non-or minimally invasive monitoring methods |
US8454997B2 (en) | 2001-12-18 | 2013-06-04 | Novo Nordisk A/S | Solid dose micro implant |
US9421166B2 (en) | 2001-12-19 | 2016-08-23 | Novartis Ag | Pulmonary delivery of aminoglycoside |
EP2272529A2 (en) | 2002-04-26 | 2011-01-12 | INSERM (Institut National de la Santé et de la Recherche Medicale) | DNA vaccine combined with an inducer of tumor cell apoptosis |
EP2272528A2 (en) | 2002-04-26 | 2011-01-12 | INSERM (Institut National de la Santé et de la Recherche Medicale) | DNA vaccine combined with an inducer of tumor cell apoptosis |
EP2272527A2 (en) | 2002-04-26 | 2011-01-12 | INSERM (Institut National de la Santé et de la Recherche Medicale) | Combined DNA vaccine and biological modifiers for cancer therapy |
US8349364B2 (en) | 2002-09-27 | 2013-01-08 | Powderject Research Limited | Nucleic acid coated particles suitable for temporary storage |
US7638332B2 (en) * | 2003-02-03 | 2009-12-29 | Bioware Technology Co., Ltd. | Low pressure gas accelerated gene gun |
DE10306716A1 (en) * | 2003-02-17 | 2004-09-02 | Lell, Peter, Dr.-Ing. | Device for injecting a dust or powdered substance into a tissue of a body |
DE10316237A1 (en) * | 2003-04-09 | 2004-11-04 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Cannula for insertion in biological organ, clasps a hollow needle with a needle end which carries a covering device separating the interior of the needle from the environment |
US9115357B2 (en) | 2004-05-12 | 2015-08-25 | Baxter International Inc. | Delivery of AS-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes |
US9339465B2 (en) | 2004-05-12 | 2016-05-17 | Baxter International, Inc. | Nucleic acid microspheres, production and delivery thereof |
US8777910B2 (en) | 2005-04-06 | 2014-07-15 | Schreiner Group Gmbh & Co. Kg | Film-based protective mechanism |
US9884155B2 (en) | 2005-04-06 | 2018-02-06 | Schreiner Group Gmbh & Co. Kg | Film-based protective mechanism |
DE102005015801A1 (en) * | 2005-04-06 | 2006-10-19 | Schreiner Group Gmbh & Co. Kg | Foil-based protection mechanism |
US8579883B2 (en) | 2005-12-16 | 2013-11-12 | Olympus Corporation | Body-insertable apparatus and medical agent discharge method |
US8298173B2 (en) | 2006-06-09 | 2012-10-30 | Bates Nigel Robert | Particle cassettes |
WO2008135719A2 (en) * | 2007-05-04 | 2008-11-13 | Powderject Research Limited | Particle cassettes and processes therefor |
US9044546B2 (en) | 2007-05-04 | 2015-06-02 | Powder Pharmaceuticals Incorporated | Particle cassettes and processes therefor |
US9358338B2 (en) | 2007-05-04 | 2016-06-07 | Powder Pharmaceuticals Incorporated | Particle cassettes and processes therefor |
WO2008135719A3 (en) * | 2007-05-04 | 2009-02-26 | Powderject Res Ltd | Particle cassettes and processes therefor |
US8448534B2 (en) | 2007-05-18 | 2013-05-28 | Malvern Instruments Incorporated | Method and apparatus for dispersing a sample of particulate material |
US8513019B2 (en) | 2009-02-05 | 2013-08-20 | Indian Institute Of Science | Apparatus and method for genetically transforming cells |
US8232093B2 (en) | 2009-02-05 | 2012-07-31 | Indian Institute Of Science | Apparatus and method for genetically transforming cells |
WO2010109016A1 (en) | 2009-03-27 | 2010-09-30 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Kanamycin antisense nucleic acid for the treatment of cancer |
WO2011154863A1 (en) | 2010-06-07 | 2011-12-15 | Pfizer Inc. | Her-2 peptides and vaccines |
IT201900007060A1 (en) | 2019-05-21 | 2020-11-21 | St Superiore Di Sanita | Engineered tumor cells and their uses |
IT201900012540A1 (en) | 2019-07-22 | 2021-01-22 | Humanitas Mirasole Spa | CHI3L1 inhibitors and their uses |
WO2021013884A1 (en) | 2019-07-22 | 2021-01-28 | Humanitas Mirasole S.P.A. | Inhibitors of chi3l1 and their uses |
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