WO1994024144A3 - Enhanced triple-helix and double-helix formation with oligomers containing modified purines - Google Patents
Enhanced triple-helix and double-helix formation with oligomers containing modified purines Download PDFInfo
- Publication number
- WO1994024144A3 WO1994024144A3 PCT/US1994/004013 US9404013W WO9424144A3 WO 1994024144 A3 WO1994024144 A3 WO 1994024144A3 US 9404013 W US9404013 W US 9404013W WO 9424144 A3 WO9424144 A3 WO 9424144A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- oligomers
- helix
- double
- triplexes
- oligomers containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU66320/94A AU6632094A (en) | 1993-04-19 | 1994-04-12 | Enhanced triple-helix and double-helix formation with oligomers containing modified purines |
EP94914131A EP0695306A1 (en) | 1993-04-19 | 1994-04-12 | Enhanced triple-helix and double-helix formation with oligomers containing modified purines |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5069893A | 1993-04-19 | 1993-04-19 | |
US08/050,698 | 1993-04-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1994024144A2 WO1994024144A2 (en) | 1994-10-27 |
WO1994024144A3 true WO1994024144A3 (en) | 1995-03-16 |
Family
ID=21966852
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1994/004013 WO1994024144A2 (en) | 1993-04-19 | 1994-04-12 | Enhanced triple-helix and double-helix formation with oligomers containing modified purines |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0695306A1 (en) |
AU (1) | AU6632094A (en) |
WO (1) | WO1994024144A2 (en) |
Families Citing this family (51)
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US5502177A (en) * | 1993-09-17 | 1996-03-26 | Gilead Sciences, Inc. | Pyrimidine derivatives for labeled binding partners |
US6150510A (en) | 1995-11-06 | 2000-11-21 | Aventis Pharma Deutschland Gmbh | Modified oligonucleotides, their preparation and their use |
DE4438918A1 (en) | 1994-11-04 | 1996-05-09 | Hoechst Ag | Modified oligonucleotides, their preparation and their use |
US5734040A (en) * | 1996-03-21 | 1998-03-31 | University Of Iowa Research Foundation | Positively charged oligonucleotides as regulators of gene expression |
US6274313B1 (en) | 1996-03-21 | 2001-08-14 | Pioneer-Hybrid International, Inc. | Oligonucleotides with cationic phosphoramidate internucleoside linkages and methods of use |
US6331617B1 (en) | 1996-03-21 | 2001-12-18 | University Of Iowa Research Foundation | Positively charged oligonucleotides as regulators of gene expression |
US6312897B1 (en) | 1996-07-03 | 2001-11-06 | President And Fellows Of Harvard College | Template-directed interference footprinting of protein-adenine contacts |
USRE44779E1 (en) | 1997-03-07 | 2014-02-25 | Santaris Pharma A/S | Bicyclonucleoside and oligonucleotide analogues |
DE19842527A1 (en) * | 1998-09-18 | 2000-03-23 | Friedrich Schiller Uni Jena Bu | Formation of a triple helix forming oligomer comprises searching for a cytosine and/or adenine-rich region of a double-stranded DNA |
EP1263773A4 (en) | 2000-03-14 | 2005-08-31 | Active Motif | Oligonucleotide analogues, methods of synthesis and methods of use |
US6962906B2 (en) | 2000-03-14 | 2005-11-08 | Active Motif | Oligonucleotide analogues, methods of synthesis and methods of use |
US7070933B2 (en) | 2001-09-28 | 2006-07-04 | Gen-Probe Incorporated | Inversion probes |
US7151089B2 (en) | 2003-10-27 | 2006-12-19 | Genelabs Technologies, Inc. | Nucleoside compounds for treating viral infections |
EP1687321A1 (en) | 2003-10-27 | 2006-08-09 | Genelabs Technologies, Inc. | Nucleoside compounds for treating viral infections |
CA2543116A1 (en) | 2003-10-27 | 2005-05-19 | Genelabs Technologies, Inc. | Methods for preparing 7-(2'-substituted-.szlig.-d-ribofuranosyl)-4-(nr2r3)-5-(substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine derivatives |
CA2542776A1 (en) | 2003-10-27 | 2005-05-12 | Genelabs Technologies, Inc. | Nucleoside compounds for treating viral infections |
US7202223B2 (en) | 2003-10-27 | 2007-04-10 | Genelabs Technologies, Inc. | Nucleoside compounds for treating viral infections |
EP2056845B1 (en) | 2006-08-08 | 2017-10-11 | Rheinische Friedrich-Wilhelms-Universität Bonn | Structure and use of 5' phosphate oligonucleotides |
ES2959127T3 (en) | 2007-06-19 | 2024-02-20 | Hoffmann La Roche | High-throughput nucleic acid sequencing by expansion |
WO2009035438A1 (en) * | 2007-09-13 | 2009-03-19 | Janos Borbely | Polymeric nanoparticles by ion-ion interactions |
US9738680B2 (en) | 2008-05-21 | 2017-08-22 | Rheinische Friedrich-Wilhelms-Universität Bonn | 5′ triphosphate oligonucleotide with blunt end and uses thereof |
CN102365367A (en) | 2009-01-29 | 2012-02-29 | 斯特拉托斯基因公司 | High throughput nucleic acid sequencing by expansion and related methods |
CA2756815A1 (en) | 2009-03-31 | 2010-10-07 | Arqule, Inc. | Peri-fused pyrazolo-pyrimidine compounds |
WO2012003330A2 (en) | 2010-06-30 | 2012-01-05 | Stratos Genomics, Inc | Multiplexed identification of nucleic acid sequences |
EP2508530A1 (en) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
US9212392B2 (en) | 2012-09-25 | 2015-12-15 | Exact Sciences Corporation | Normalization of polymerase activity |
EP2712870A1 (en) | 2012-09-27 | 2014-04-02 | Rheinische Friedrich-Wilhelms-Universität Bonn | Novel RIG-I ligands and methods for producing them |
US20140287946A1 (en) | 2013-03-14 | 2014-09-25 | Ibis Biosciences, Inc. | Nucleic acid control panels |
EP3221327A1 (en) | 2014-11-20 | 2017-09-27 | Stratos Genomics, Inc. | Nulceoside phosphoroamidate esters and derivatives thereof, use and synthesis thereof |
HUE056470T2 (en) | 2014-12-26 | 2022-02-28 | Univ Emory | Anti-viral n4-hydroxycytidine derivatives |
WO2017075061A1 (en) | 2015-10-30 | 2017-05-04 | Exact Sciences Corporation | Multiplex amplification detection assay and isolation and detection of dna from plasma |
EP3377648B1 (en) | 2015-11-16 | 2021-01-06 | Stratos Genomics, Inc. | Dp04 polymerase variants |
US10385406B2 (en) | 2016-05-05 | 2019-08-20 | Exact Sciences Development Company, Llc | Detection of lung neoplasia by analysis of methylated DNA |
WO2018140781A1 (en) | 2017-01-27 | 2018-08-02 | Exact Sciences Development Company, Llc | Detection of colon neoplasia by analysis of methylated dna |
CA3061651A1 (en) | 2017-05-04 | 2018-11-08 | Stratos Genomics, Inc. | Dp04 polymerase variants |
KR102248165B1 (en) | 2017-12-07 | 2021-05-06 | 에모리 유니버시티 | N4-hydroxycytidine and derivatives and related anti-viral uses |
JP7288457B2 (en) | 2017-12-11 | 2023-06-07 | ストラトス ゲノミクス インコーポレイテッド | DPO4 polymerase variants with improved fidelity |
US10648025B2 (en) | 2017-12-13 | 2020-05-12 | Exact Sciences Development Company, Llc | Multiplex amplification detection assay II |
GB2605952A (en) * | 2021-04-12 | 2022-10-26 | Stealth Labels Biotech Ab | Fluorescent nucleoside triphosphates |
US20220403450A1 (en) | 2021-06-03 | 2022-12-22 | Illumina Software, Inc. | Systems and methods for sequencing nucleotides using two optical channels |
WO2023278781A1 (en) | 2021-07-01 | 2023-01-05 | Illumina, Inc. | Device having horizontal nanochannel for nanopore sequencing |
CN117580961A (en) | 2021-09-01 | 2024-02-20 | Illumina公司 | Amplitude modulation for accelerating base interpretation |
WO2023049682A1 (en) | 2021-09-22 | 2023-03-30 | Illumina, Inc. | Sequencing polynucleotides using nanopores |
US20230112203A1 (en) | 2021-09-30 | 2023-04-13 | Illumina, Inc. | Isolation of cells in a nanopore sensor array |
WO2023086391A1 (en) | 2021-11-15 | 2023-05-19 | Illumina, Inc. | Nanopore systems and methods of fabrication |
US20230183799A1 (en) | 2021-12-10 | 2023-06-15 | Illumina, Inc. | Parallel sample and index sequencing |
WO2023175021A1 (en) | 2022-03-15 | 2023-09-21 | Illumina, Inc. | Methods of preparing loop fork libraries |
US20230357307A1 (en) | 2022-05-04 | 2023-11-09 | Illumina, Inc. | Cleavable cyclic loop nucleotides for nanopore sequencing |
WO2023239660A1 (en) | 2022-06-07 | 2023-12-14 | Illumina Software, Inc. | Methods and systems for identifying gene variants |
WO2024010812A2 (en) | 2022-07-07 | 2024-01-11 | Illumina Software, Inc. | Methods and systems for determining copy number variant genotypes |
WO2024010809A2 (en) | 2022-07-07 | 2024-01-11 | Illumina Software, Inc. | Methods and systems for detecting recombination events |
Citations (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3309358A (en) * | 1965-09-20 | 1967-03-14 | Upjohn Co | 7-deazaadenine 2', 5'-and 3', 5'-dinucleoside phosphate and process therefor |
US3337530A (en) * | 1965-09-20 | 1967-08-22 | Upjohn Co | Dinucleoside 3', 5' -and 2', 5'-phosphates containing one 7-deazapurin riboside moiety |
US3962211A (en) * | 1975-01-13 | 1976-06-08 | The University Of Utah | 7-substituted nucleoside compounds |
EP0021293A2 (en) * | 1979-06-14 | 1981-01-07 | The Wellcome Foundation Limited | 4-Substituted thio-1-beta-D-ribofuranosylpyrazolo(3,4-D) pyrimidines, processes for their preparation, pharmaceutical formulations and medical uses |
EP0057548A2 (en) * | 1981-01-29 | 1982-08-11 | Warner-Lambert Company | 7-Beta-D-arabinofuranosyl-7H-pyrrolo(2,3-d)pyrimidine-4-amine 5'-phosphate compounds useful as antiviral agents, pharmaceutical compositions containing the compounds, and processes for producing the compounds |
EP0251786A2 (en) * | 1986-07-02 | 1988-01-07 | E.I. Du Pont De Nemours And Company | Alkynylamino-nucleotides |
EP0286028A2 (en) * | 1987-04-10 | 1988-10-12 | Roche Diagnostics GmbH | Derivatives of disazapurine nucleosides, process for their preparation and their use in the sequence analysis of nucleic acids and as antiviral agents |
WO1989012060A1 (en) * | 1988-06-06 | 1989-12-14 | Steven Albert Benner | Oligonucleotide analogs containing sulfur |
WO1989012380A2 (en) * | 1988-06-09 | 1989-12-28 | Temple University Of The Commonwealth System Of Hi | Therapeutic uses of 2',5'-oligoadenylate derivatives |
WO1990003370A1 (en) * | 1988-09-28 | 1990-04-05 | Microprobe Corporation | DERIVATIVES OF PYRAZOLO[3,4-d]PYRIMIDINE |
EP0450102A1 (en) * | 1989-10-26 | 1991-10-09 | Yamasa Shoyu Kabushiki Kaisha | Nucleoside derivative |
WO1993003736A1 (en) * | 1991-08-21 | 1993-03-04 | Microprobe Corporation | Cross-linking oligonucleotides for enzyme-mediated triple strand formation |
WO1993009127A1 (en) * | 1991-11-07 | 1993-05-13 | Gilead Sciences, Inc. | Enhanced triple-helix formation directed by oligonucleotides composed of 2'-deoxy-7-deazaxanthosine and 2'-deoxy-7-deazaguanosine and related analogs |
WO1993012130A1 (en) * | 1991-12-09 | 1993-06-24 | Boehringer Mannheim Gmbh | 2'-desoxy-isoguanosines, isoster analogues and isoguanosine derivates and their use |
-
1994
- 1994-04-12 AU AU66320/94A patent/AU6632094A/en not_active Abandoned
- 1994-04-12 WO PCT/US1994/004013 patent/WO1994024144A2/en not_active Application Discontinuation
- 1994-04-12 EP EP94914131A patent/EP0695306A1/en not_active Withdrawn
Patent Citations (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3309358A (en) * | 1965-09-20 | 1967-03-14 | Upjohn Co | 7-deazaadenine 2', 5'-and 3', 5'-dinucleoside phosphate and process therefor |
US3337530A (en) * | 1965-09-20 | 1967-08-22 | Upjohn Co | Dinucleoside 3', 5' -and 2', 5'-phosphates containing one 7-deazapurin riboside moiety |
US3962211A (en) * | 1975-01-13 | 1976-06-08 | The University Of Utah | 7-substituted nucleoside compounds |
EP0021293A2 (en) * | 1979-06-14 | 1981-01-07 | The Wellcome Foundation Limited | 4-Substituted thio-1-beta-D-ribofuranosylpyrazolo(3,4-D) pyrimidines, processes for their preparation, pharmaceutical formulations and medical uses |
EP0057548A2 (en) * | 1981-01-29 | 1982-08-11 | Warner-Lambert Company | 7-Beta-D-arabinofuranosyl-7H-pyrrolo(2,3-d)pyrimidine-4-amine 5'-phosphate compounds useful as antiviral agents, pharmaceutical compositions containing the compounds, and processes for producing the compounds |
EP0251786A2 (en) * | 1986-07-02 | 1988-01-07 | E.I. Du Pont De Nemours And Company | Alkynylamino-nucleotides |
EP0286028A2 (en) * | 1987-04-10 | 1988-10-12 | Roche Diagnostics GmbH | Derivatives of disazapurine nucleosides, process for their preparation and their use in the sequence analysis of nucleic acids and as antiviral agents |
WO1989012060A1 (en) * | 1988-06-06 | 1989-12-14 | Steven Albert Benner | Oligonucleotide analogs containing sulfur |
WO1989012380A2 (en) * | 1988-06-09 | 1989-12-28 | Temple University Of The Commonwealth System Of Hi | Therapeutic uses of 2',5'-oligoadenylate derivatives |
WO1990003370A1 (en) * | 1988-09-28 | 1990-04-05 | Microprobe Corporation | DERIVATIVES OF PYRAZOLO[3,4-d]PYRIMIDINE |
EP0450102A1 (en) * | 1989-10-26 | 1991-10-09 | Yamasa Shoyu Kabushiki Kaisha | Nucleoside derivative |
WO1993003736A1 (en) * | 1991-08-21 | 1993-03-04 | Microprobe Corporation | Cross-linking oligonucleotides for enzyme-mediated triple strand formation |
WO1993009127A1 (en) * | 1991-11-07 | 1993-05-13 | Gilead Sciences, Inc. | Enhanced triple-helix formation directed by oligonucleotides composed of 2'-deoxy-7-deazaxanthosine and 2'-deoxy-7-deazaguanosine and related analogs |
WO1993012130A1 (en) * | 1991-12-09 | 1993-06-24 | Boehringer Mannheim Gmbh | 2'-desoxy-isoguanosines, isoster analogues and isoguanosine derivates and their use |
Non-Patent Citations (4)
Title |
---|
F. SEELA: "Palindromic oligonucleotides containing 7-deaza-2'-deoxyguanosine", NUCLEIC ACIDS RES., vol. 14, 1986, pages 2319 - 32 * |
F. SEELA: "Poly(adenylic acids) containing the antibiotic tubercidin", NUCLEIC ACIDS RES., vol. 10, 1982, pages 1389 - 97 * |
J.F. MILLIGAN: "An anti-parallel triple helix motif with oligodeoxynucleotides containing 2'-deoxyguanosine and 7-deaza-2'-deoxy-xanthosine", NUCLEIC ACIDS RES., vol. 21, 25 January 1993 (1993-01-25), pages 327 - 33 * |
M. IKEHARA: "Polynucleotides III.", CHEM. PHARM. BULL., vol. 14, 1966, pages 1338 - 46 * |
Also Published As
Publication number | Publication date |
---|---|
AU6632094A (en) | 1994-11-08 |
EP0695306A1 (en) | 1996-02-07 |
WO1994024144A2 (en) | 1994-10-27 |
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