WO1994021236A1 - Cross-linked amylose as a binder/disintegrant in tablets - Google Patents
Cross-linked amylose as a binder/disintegrant in tablets Download PDFInfo
- Publication number
- WO1994021236A1 WO1994021236A1 PCT/CA1994/000163 CA9400163W WO9421236A1 WO 1994021236 A1 WO1994021236 A1 WO 1994021236A1 CA 9400163 W CA9400163 W CA 9400163W WO 9421236 A1 WO9421236 A1 WO 9421236A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cross
- tablet
- amylose
- tablets
- cla
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU62799/94A AU679732B2 (en) | 1993-03-25 | 1994-03-22 | Cross-linked amylose as a binder/disintegrant in tablets |
EP94910298A EP0689429B1 (en) | 1993-03-25 | 1994-03-22 | Cross-linked amylose as a binder/disintegrant in tablets |
DE69400356T DE69400356T2 (en) | 1993-03-25 | 1994-03-22 | CROSS-CROSS-LINKED AMYLOSE AS A BINDING AGENT / BLASTING AGENT FOR TABLETS |
FI954232A FI954232A (en) | 1993-03-25 | 1995-09-08 | Silylated amylose as a binder / disintegrant in tablets |
NO953767A NO953767L (en) | 1993-03-25 | 1995-09-22 | Crosslinked amylose as a binder / dissolving agent in tablets |
GR960402806T GR3021433T3 (en) | 1993-03-25 | 1996-10-23 | Cross-linked amylose as a binder/disintegrant in tablets |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/037,119 US5616343A (en) | 1993-03-25 | 1993-03-25 | Cross-linked amylose as a binder/disintegrant in tablets |
US08/037,119 | 1993-03-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1994021236A1 true WO1994021236A1 (en) | 1994-09-29 |
Family
ID=21892532
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA1994/000163 WO1994021236A1 (en) | 1993-03-25 | 1994-03-22 | Cross-linked amylose as a binder/disintegrant in tablets |
Country Status (17)
Country | Link |
---|---|
US (1) | US5616343A (en) |
EP (1) | EP0689429B1 (en) |
JP (1) | JP2831851B2 (en) |
CN (1) | CN1119828A (en) |
AT (1) | ATE141046T1 (en) |
AU (1) | AU679732B2 (en) |
CA (1) | CA2155210A1 (en) |
CZ (1) | CZ285201B6 (en) |
DE (1) | DE69400356T2 (en) |
ES (1) | ES2091142T3 (en) |
FI (1) | FI954232A (en) |
GR (1) | GR3021433T3 (en) |
HU (1) | HUT73667A (en) |
NO (1) | NO953767L (en) |
NZ (1) | NZ262876A (en) |
PL (1) | PL310815A1 (en) |
WO (1) | WO1994021236A1 (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997037639A1 (en) * | 1996-04-10 | 1997-10-16 | Labopharm Inc. | Controlled-release pharmaceutical tablet containing a carrier based on cross-linked amylose and hydroxypropylmethylcellulose |
WO1998013028A1 (en) * | 1996-09-28 | 1998-04-02 | Lts Lohmann Therapie-Systeme Gmbh | Oral preparation containing at least one active pharmaceutical substance in a matrix capable of swelling in an aqueous medium |
US5879707A (en) * | 1996-10-30 | 1999-03-09 | Universite De Montreal | Substituted amylose as a matrix for sustained drug release |
WO1999043305A1 (en) * | 1998-02-24 | 1999-09-02 | Vincent Lenaerts | Cross-linked high amylose starch having functional groups as a matrix for the slow release of pharmaceutical agents |
US5989589A (en) * | 1997-10-24 | 1999-11-23 | Cartilier; Louis | Cross-linked cellulose as a tablet excipient |
US6607748B1 (en) | 2000-06-29 | 2003-08-19 | Vincent Lenaerts | Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture |
US6660303B2 (en) | 1999-12-06 | 2003-12-09 | Edward Mendell & Co. | Pharmaceutical superdisintegrant |
WO2012003968A1 (en) | 2010-07-06 | 2012-01-12 | Grünenthal GmbH | Novel gastro- retentive dosage forms comprising a gaba analog and an opioid |
WO2012007159A2 (en) | 2010-07-14 | 2012-01-19 | Grünenthal GmbH | Novel gastro-retentive dosage forms |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL119660A (en) | 1993-05-10 | 2002-09-12 | Euro Celtique Sa | Controlled release formulation comprising tramadol |
ZA984336B (en) * | 1997-05-21 | 1998-11-30 | Warner Lambert Co | Non-sedating acrivastine product |
TWI319713B (en) * | 2002-10-25 | 2010-01-21 | Sustained-release tramadol formulations with 24-hour efficacy | |
US8487002B2 (en) * | 2002-10-25 | 2013-07-16 | Paladin Labs Inc. | Controlled-release compositions |
US6846497B2 (en) | 2003-01-30 | 2005-01-25 | National Starch And Chemical Investment Holding Corporation | Rapidly expanding starches with altered crystalline structure |
US20070071810A1 (en) * | 2003-08-26 | 2007-03-29 | Kenichi Kudo | Additive for tablets |
NO319624B1 (en) * | 2003-09-15 | 2005-09-05 | Trouw Internat Bv | Fish feed for salmonids in fresh water and use of such feed. |
US20060172006A1 (en) * | 2003-10-10 | 2006-08-03 | Vincent Lenaerts | Sustained-release tramadol formulations with 24-hour clinical efficacy |
US8871270B2 (en) * | 2004-07-09 | 2014-10-28 | Corn Products Development, Inc | Tablet excipient |
CA2491665A1 (en) * | 2004-12-24 | 2006-06-24 | Louis Cartilier | Tablet formulation for the sustained release of active substances |
EP1717215A1 (en) * | 2005-04-19 | 2006-11-02 | Lafarge | Process for compacting a hydraulic binder and ground tablets |
KR101655455B1 (en) * | 2005-09-09 | 2016-09-07 | 안젤리니 라보팜 엘엘씨 | Trazodone composition for once a day administration |
AU2008314454A1 (en) * | 2007-10-16 | 2009-04-23 | Labopharm (Barbados) Limited | Bilayer composition for the sustained release of acetaminophen and tramadol |
JP5651818B2 (en) | 2007-12-17 | 2015-01-14 | パラディン ラブス インコーポレーテッド | Controlled release formulation to prevent misuse |
CN101981059B (en) | 2008-03-31 | 2014-08-20 | 旭化成化学株式会社 | Processed starch powder with excellent disintegration properties and manufacturing method thereof |
CA2746888C (en) | 2008-12-16 | 2015-05-12 | Labopharm (Barbados) Limited | Misuse preventative, controlled release formulation |
CN108456050A (en) * | 2018-01-24 | 2018-08-28 | 天津水泥工业设计研究院有限公司 | A kind of pelletizing additives of the production rounded grain mineral fertilizer of low cost |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3622677A (en) * | 1969-07-07 | 1971-11-23 | Staley Mfg Co A E | Compressed tablets containing compacted starch as binder-disintegrant ingredient |
CA2041774A1 (en) * | 1990-11-27 | 1992-05-28 | Mircea A. Mateescu | Use of cross-linked amylose as a matrix for the slow release of biologically active compounds |
EP0499648A1 (en) * | 1990-12-17 | 1992-08-26 | National Starch and Chemical Investment Holding Corporation | Enzymatically debranched starches as tablet excipients |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2987445A (en) * | 1958-10-10 | 1961-06-06 | Rohm & Haas | Drug composition |
US3087860A (en) * | 1958-12-19 | 1963-04-30 | Abbott Lab | Method of prolonging release of drug from a precompressed solid carrier |
US4072535A (en) * | 1970-12-28 | 1978-02-07 | A. E. Staley Manufacturing Company | Precompacted-starch binder-disintegrant-filler material for direct compression tablets and dry dosage capsules |
US4088798A (en) * | 1975-11-11 | 1978-05-09 | Sandoz, Inc. | Methods for the preparation of controlled gastric residence time medicament formulations |
US4230687A (en) * | 1978-05-30 | 1980-10-28 | Griffith Laboratories U.S.A., Inc. | Encapsulation of active agents as microdispersions in homogeneous natural polymeric matrices |
JPS6042766B2 (en) * | 1978-12-09 | 1985-09-25 | 日本化薬株式会社 | Base |
US4369308A (en) * | 1981-07-24 | 1983-01-18 | National Starch And Chemical Corporation | Low swelling starches as tablet disintegrants |
US4713249A (en) * | 1981-11-12 | 1987-12-15 | Schroeder Ulf | Crystallized carbohydrate matrix for biologically active substances, a process of preparing said matrix, and the use thereof |
GB8319766D0 (en) * | 1983-07-22 | 1983-08-24 | Graham N B | Controlled release device |
IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
US4933185A (en) * | 1986-09-24 | 1990-06-12 | Massachusetts Institute Of Technology | System for controlled release of biologically active compounds |
US4761289A (en) * | 1986-10-10 | 1988-08-02 | International Minerals & Chemical Corp. | Sustained release implant and method for preparing same |
US4755397A (en) * | 1986-12-24 | 1988-07-05 | National Starch And Chemical Corporation | Starch based particulate encapsulation process |
US4812445A (en) * | 1987-02-06 | 1989-03-14 | National Starch And Chemical Corporation | Starch based encapsulation process |
GB8812490D0 (en) * | 1988-05-26 | 1988-06-29 | Agricultural & Food Res | Delayed release formulations |
-
1993
- 1993-03-25 US US08/037,119 patent/US5616343A/en not_active Expired - Fee Related
-
1994
- 1994-03-22 CN CN94191573A patent/CN1119828A/en active Pending
- 1994-03-22 AT AT94910298T patent/ATE141046T1/en not_active IP Right Cessation
- 1994-03-22 PL PL94310815A patent/PL310815A1/en unknown
- 1994-03-22 CZ CZ952486A patent/CZ285201B6/en unknown
- 1994-03-22 NZ NZ262876A patent/NZ262876A/en unknown
- 1994-03-22 CA CA002155210A patent/CA2155210A1/en not_active Abandoned
- 1994-03-22 HU HU9502790A patent/HUT73667A/en unknown
- 1994-03-22 WO PCT/CA1994/000163 patent/WO1994021236A1/en active IP Right Grant
- 1994-03-22 DE DE69400356T patent/DE69400356T2/en not_active Expired - Fee Related
- 1994-03-22 ES ES94910298T patent/ES2091142T3/en not_active Expired - Lifetime
- 1994-03-22 EP EP94910298A patent/EP0689429B1/en not_active Expired - Lifetime
- 1994-03-22 JP JP6520457A patent/JP2831851B2/en not_active Expired - Lifetime
- 1994-03-22 AU AU62799/94A patent/AU679732B2/en not_active Ceased
-
1995
- 1995-09-08 FI FI954232A patent/FI954232A/en unknown
- 1995-09-22 NO NO953767A patent/NO953767L/en unknown
-
1996
- 1996-10-23 GR GR960402806T patent/GR3021433T3/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3622677A (en) * | 1969-07-07 | 1971-11-23 | Staley Mfg Co A E | Compressed tablets containing compacted starch as binder-disintegrant ingredient |
CA2041774A1 (en) * | 1990-11-27 | 1992-05-28 | Mircea A. Mateescu | Use of cross-linked amylose as a matrix for the slow release of biologically active compounds |
EP0499648A1 (en) * | 1990-12-17 | 1992-08-26 | National Starch and Chemical Investment Holding Corporation | Enzymatically debranched starches as tablet excipients |
Non-Patent Citations (2)
Title |
---|
DATABASE WPI Week 9233, Derwent World Patents Index; AN 92-269220 (33) * |
V.LENAERTS ET AL.: "CROSSLINKED AMYLOSE TABLETS FOR CONTROLLED-RELEASE OF DRUGS", PROC. OF THE 19TH INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1992, pages 30 - 31 * |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997037639A1 (en) * | 1996-04-10 | 1997-10-16 | Labopharm Inc. | Controlled-release pharmaceutical tablet containing a carrier based on cross-linked amylose and hydroxypropylmethylcellulose |
US6238698B1 (en) | 1996-09-28 | 2001-05-29 | Lts Lohmann Therapie-Systeme Gmbh | Oral preparation containing at least one active pharmaceutical substance in a matrix capable of swelling in an aqueous medium |
WO1998013028A1 (en) * | 1996-09-28 | 1998-04-02 | Lts Lohmann Therapie-Systeme Gmbh | Oral preparation containing at least one active pharmaceutical substance in a matrix capable of swelling in an aqueous medium |
DE19640062A1 (en) * | 1996-09-28 | 1998-04-09 | Lohmann Therapie Syst Lts | Oral preparation containing at least one active pharmaceutical ingredient in a matrix swellable in aqueous medium |
DE19640062B4 (en) * | 1996-09-28 | 2006-04-27 | Lts Lohmann Therapie-Systeme Ag | Oral preparation comprising in a matrix swellable in an aqueous medium at least one pharmaceutical active substance |
US5879707A (en) * | 1996-10-30 | 1999-03-09 | Universite De Montreal | Substituted amylose as a matrix for sustained drug release |
US5989589A (en) * | 1997-10-24 | 1999-11-23 | Cartilier; Louis | Cross-linked cellulose as a tablet excipient |
AU755069B2 (en) * | 1998-02-24 | 2002-12-05 | Francois Chouinard | Cross-linked high amylose starch having functional groups as a matrix for the slow release of pharmaceutical agents |
WO1999043305A1 (en) * | 1998-02-24 | 1999-09-02 | Vincent Lenaerts | Cross-linked high amylose starch having functional groups as a matrix for the slow release of pharmaceutical agents |
KR100713702B1 (en) * | 1998-02-24 | 2007-05-02 | 빈센트 레나르트 | Cross-linked high amylose starch having functional groups as a matrix for the slow release of pharmaceutical agents |
CZ301010B6 (en) * | 1998-02-24 | 2009-10-14 | Pharmaceutical composition | |
US6660303B2 (en) | 1999-12-06 | 2003-12-09 | Edward Mendell & Co. | Pharmaceutical superdisintegrant |
US6607748B1 (en) | 2000-06-29 | 2003-08-19 | Vincent Lenaerts | Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture |
WO2012003968A1 (en) | 2010-07-06 | 2012-01-12 | Grünenthal GmbH | Novel gastro- retentive dosage forms comprising a gaba analog and an opioid |
WO2012007159A2 (en) | 2010-07-14 | 2012-01-19 | Grünenthal GmbH | Novel gastro-retentive dosage forms |
Also Published As
Publication number | Publication date |
---|---|
EP0689429B1 (en) | 1996-08-07 |
US5616343A (en) | 1997-04-01 |
NO953767D0 (en) | 1995-09-22 |
CN1119828A (en) | 1996-04-03 |
FI954232A0 (en) | 1995-09-08 |
NO953767L (en) | 1995-09-22 |
NZ262876A (en) | 1997-01-29 |
AU679732B2 (en) | 1997-07-10 |
EP0689429A1 (en) | 1996-01-03 |
DE69400356D1 (en) | 1996-09-12 |
HUT73667A (en) | 1996-09-30 |
PL310815A1 (en) | 1996-01-08 |
DE69400356T2 (en) | 1996-11-28 |
JP2831851B2 (en) | 1998-12-02 |
CA2155210A1 (en) | 1994-09-29 |
JPH08507769A (en) | 1996-08-20 |
CZ248695A3 (en) | 1996-01-17 |
GR3021433T3 (en) | 1997-01-31 |
AU6279994A (en) | 1994-10-11 |
HU9502790D0 (en) | 1995-11-28 |
ATE141046T1 (en) | 1996-08-15 |
ES2091142T3 (en) | 1996-10-16 |
CZ285201B6 (en) | 1999-06-16 |
FI954232A (en) | 1995-09-08 |
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