WO1994020617A3 - Human neuronal nicotinic acetylcholine receptor compositions and methods employing same - Google Patents

Human neuronal nicotinic acetylcholine receptor compositions and methods employing same Download PDF

Info

Publication number
WO1994020617A3
WO1994020617A3 PCT/US1994/002447 US9402447W WO9420617A3 WO 1994020617 A3 WO1994020617 A3 WO 1994020617A3 US 9402447 W US9402447 W US 9402447W WO 9420617 A3 WO9420617 A3 WO 9420617A3
Authority
WO
WIPO (PCT)
Prior art keywords
subunits
alpha
acetylcholine receptor
nicotinic acetylcholine
neuronal nicotinic
Prior art date
Application number
PCT/US1994/002447
Other languages
French (fr)
Other versions
WO1994020617A2 (en
Inventor
Kathryn J Elliott
Steven B Ellis
Michael M Harpold
Original Assignee
Salk Inst Biotech Ind
Kathryn J Elliott
Steven B Ellis
Michael M Harpold
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Inst Biotech Ind, Kathryn J Elliott, Steven B Ellis, Michael M Harpold filed Critical Salk Inst Biotech Ind
Priority to EP94912758A priority Critical patent/EP0688361B1/en
Priority to CA002155330A priority patent/CA2155330C/en
Priority to JP52024094A priority patent/JP3628691B2/en
Priority to DE69434067T priority patent/DE69434067T2/en
Priority to AU65173/94A priority patent/AU694424B2/en
Priority to AT94912758T priority patent/ATE279516T1/en
Priority to GB9503688A priority patent/GB2286397C/en
Publication of WO1994020617A2 publication Critical patent/WO1994020617A2/en
Publication of WO1994020617A3 publication Critical patent/WO1994020617A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor

Abstract

Nucleic acids encoding human neuronal nicotinic acetylcholine receptor alpha 4 subunits, mammalian and amphibian cells containing said nucleic acids, methods for producing alpha 4 subunits and recombinant (i.e. isolated or substantially pure) alpha 4 subunits are provided. In addition, combinations of subunits (i.e. alpha 4 subunits in combination with beta 4 subunits; or alpha 4 subunits in combination with alpha 7 and/or beta 4 subunits) are provided.
PCT/US1994/002447 1993-03-08 1994-03-08 Human neuronal nicotinic acetylcholine receptor compositions and methods employing same WO1994020617A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP94912758A EP0688361B1 (en) 1993-03-08 1994-03-08 Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
CA002155330A CA2155330C (en) 1993-03-08 1994-03-08 Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
JP52024094A JP3628691B2 (en) 1993-03-08 1994-03-08 Human neuronal nicotinic acetylcholine receptor compositions and methods for their use
DE69434067T DE69434067T2 (en) 1993-03-08 1994-03-08 HUMAN NEURONAL NICOTIN ACETYLCHOLINE RECEPTOR COMPOUNDS AND METHODS OF ITS USE
AU65173/94A AU694424B2 (en) 1993-03-08 1994-03-08 Human neuronal nicotinic acetylcholine receptor compositionsand methods employing same
AT94912758T ATE279516T1 (en) 1993-03-08 1994-03-08 HUMAN NEURONAL NICOTINE-ACETYLCHOLINE RECEPTOR COMPOUNDS AND METHODS OF THEIR USE
GB9503688A GB2286397C (en) 1993-03-08 1994-03-08 Human neuronal nicotinic acetylcholine receptor compositions and methods of applying same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2803193A 1993-03-08 1993-03-08
US08/028,031 1993-03-08

Publications (2)

Publication Number Publication Date
WO1994020617A2 WO1994020617A2 (en) 1994-09-15
WO1994020617A3 true WO1994020617A3 (en) 1994-10-27

Family

ID=21841175

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/002447 WO1994020617A2 (en) 1993-03-08 1994-03-08 Human neuronal nicotinic acetylcholine receptor compositions and methods employing same

Country Status (10)

Country Link
US (5) US5837489A (en)
EP (2) EP0688361B1 (en)
JP (2) JP3628691B2 (en)
AT (1) ATE279516T1 (en)
AU (1) AU694424B2 (en)
CA (1) CA2155330C (en)
DE (1) DE69434067T2 (en)
ES (1) ES2229216T3 (en)
GB (1) GB2286397C (en)
WO (1) WO1994020617A2 (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6936457B1 (en) * 1990-04-03 2005-08-30 Merck & Co., Inc. DNA ENCODING HUMAN α AND β SUBUNITS OF NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR, CELLS TRANSFORMED THEREWITH, AND RECOMBINANT CELL LINE EXPRESSING A HUMAN α AND β SUBUNIT OF NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR
EP0688361B1 (en) 1993-03-08 2004-10-13 Merck & Co., Inc. Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
US6485967B1 (en) * 1995-06-07 2002-11-26 Merck & Co., Inc. Human neuronal nicotinic acetylcholine receptor α6 and β3 nucleic acid
CA2190304A1 (en) * 1995-12-15 1997-06-16 Elazar Rabbani Property effecting and/or property exhibiting compositions for therapeutic and diagnostic uses
US6323000B2 (en) * 1996-12-20 2001-11-27 Clark A. Briggs Variant human α7 acetylcholine receptor subunit, and methods of production and uses thereof
CA2293254A1 (en) * 1997-06-13 1998-12-23 Allelix Biopharmaceuticals Inc. Assay methods and compositions useful for measuring receptor ligand binding
US6875606B1 (en) * 1997-10-23 2005-04-05 The United States Of America As Represented By The Department Of Veterans Affairs Human α-7 nicotinic receptor promoter
US6632823B1 (en) 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
EP0953637A3 (en) * 1998-03-24 2001-04-25 Smithkline Beecham Plc Acetylcholine receptor
US6252132B1 (en) 1998-11-02 2001-06-26 Institut Pasteur Mutant mouse containing a knockout mutation in DNA encoding an endogenous alpha 4 subunit of nicotinic acetylcholine receptor
US6693172B1 (en) 1999-05-27 2004-02-17 Pharmacia And Upjohn Company Double mutant alpha-7 nicotinic acetylcholine receptor
JP2003501022A (en) 1999-05-27 2003-01-14 ファルマシア・アンド・アップジョン・カンパニー Method for measuring ion channel conductance and composition thereof
GB9913248D0 (en) * 1999-06-09 1999-08-04 Babraham Inst Recombinant nematode nicotinic receptor and uses
US6737270B1 (en) 1999-12-07 2004-05-18 University Of Pittsburgh Of The Commonwealth System Of Higher Education Long-term three dimensional tissue culture system
US20030096411A1 (en) * 1999-12-07 2003-05-22 George Michalopoulos Novel long-term three-dimensional tissue culture system
DE19959582A1 (en) * 1999-12-10 2001-06-13 Bayer Ag Nucleic acids encoding new acetylcholine receptor beta subunits of insects
GB2364385B (en) * 2000-03-29 2002-08-14 Synaptica Ltd Alpha 7 nicotinic receptor screening assays
US6492385B2 (en) 2000-08-18 2002-12-10 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
JP2004506735A (en) 2000-08-18 2004-03-04 ファルマシア・アンド・アップジョン・カンパニー Quinuclidine-substituted aryl compounds for disease treatment
WO2002016357A2 (en) 2000-08-18 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands)
WO2002017358A2 (en) 2000-08-21 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists)
US6599916B2 (en) 2000-08-21 2003-07-29 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
AU2002215977A1 (en) * 2000-10-31 2002-05-15 Bayer Aktiengesellschaft Regulation of human serotonin receptor precursor
PE20021019A1 (en) 2001-04-19 2002-11-13 Upjohn Co SUBSTITUTED AZABYCLE GROUPS
AU2002324842C9 (en) * 2001-08-31 2008-07-10 Agensys, Inc. 205P1B5 in treatment and detection of cancer
WO2003023014A2 (en) * 2001-09-12 2003-03-20 Pharmacia & Upjohn Company Human ion channels
US7229779B2 (en) 2001-09-18 2007-06-12 Abbott Laboratories Variant human α7 acetylcholine receptor subunit, and methods of production and use thereof
US20060126682A1 (en) * 2001-10-08 2006-06-15 Geola Technologies Ltd. Pulsed multiple colour laser system
AU2003267174A1 (en) * 2002-05-09 2003-11-11 Memory Pharmaceuticals Corporation Qm-7 and qt-6 cells transfected with mutant cell surface expressed channel receptors and assays using the transfected cells
JP2005537297A (en) * 2002-08-01 2005-12-08 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 1H-pyrazole and 1H-pyrrole-azabicyclo compounds having alpha-7NACHR activity
US20040151729A1 (en) * 2002-10-28 2004-08-05 George Michalopoulos Novel long-term three-dimensional culture system
US20060142188A1 (en) * 2003-02-14 2006-06-29 Memory Pharmaceuticals Corporation Monkey alpha-7 nicotinic acetylcholine receptor and methods of use thereof
US7576878B2 (en) * 2003-04-03 2009-08-18 Hewlett-Packard Development Company, L.P. Enhanced management of raster image processing resources
WO2005030145A2 (en) * 2003-09-24 2005-04-07 Targacept, Inc. Composition and pharmacology of novel alpha-6-containing nicotinic acetylcholine receptors
WO2005085416A1 (en) * 2004-03-04 2005-09-15 Riken Method of screening fungus-specific antimicrobial agent and kit therefor
DE602006019653D1 (en) * 2005-01-20 2011-03-03 Lg Electronics Inc Plasma display panel
CN101180543B (en) * 2005-02-23 2014-06-18 美国陶氏益农公司 Novel assays utilizing nicotinic acetylcholine receptor subunits
US7879913B2 (en) * 2005-06-28 2011-02-01 Catholic Healthcare West Iptakalim hydrochloride for decreasing nicotine use
WO2018057837A1 (en) * 2016-09-23 2018-03-29 Ionis Pharmaceuticals, Inc. Gene therapy and targeted delivery of conjugated compounds
CN111741760A (en) * 2017-11-27 2020-10-02 科达生物治疗医药有限公司 Compositions and methods for neurological disorders

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990010648A1 (en) * 1989-03-14 1990-09-20 The Salk Institute For Biological Studies Neuronal nicotinic acetylcholine receptor compositions containing the beta4 subunit
WO1991015602A1 (en) * 1990-04-03 1991-10-17 The Salk Institute Biotechnology/Industrial Associates, Inc. Human neuronal nicotinic acetylcholine receptor compositions and methods employing same

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4703008A (en) * 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
US4837148A (en) * 1984-10-30 1989-06-06 Phillips Petroleum Company Autonomous replication sequences for yeast strains of the genus pichia
US4855231A (en) * 1984-10-30 1989-08-08 Phillips Petroleum Company Regulatory region for heterologous gene expression in yeast
US4882279A (en) * 1985-10-25 1989-11-21 Phillips Petroleum Company Site selective genomic modification of yeast of the genus pichia
US4859609A (en) * 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
US5071773A (en) * 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US5024939A (en) * 1987-07-09 1991-06-18 Genentech, Inc. Transient expression system for producing recombinant protein
US4929555A (en) * 1987-10-19 1990-05-29 Phillips Petroleum Company Pichia transformation
US4981784A (en) * 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
US5449606A (en) * 1988-03-18 1995-09-12 The Salk Institute For Biological Studies DNA encoding neuronal nicotinic acetylcholine receptor compositions containing the beta 4 subunit
CA1341554C (en) * 1988-03-18 2007-10-09 The Salk Institute For Biological Studies Neuronal nicotinic acetylcholine receptor compositions and assay
CA1341170C (en) * 1988-04-04 2001-01-16 Steven B. Ellis Calcium channel compositions and methods
US5386025A (en) * 1990-02-20 1995-01-31 The Salk Institute Biotechnology/Industrial Associates Calcium channel compositions and methods
AU648523B2 (en) * 1989-10-25 1994-04-28 Salk Institute For Biological Studies, The Receptor infection assay
US5091518A (en) * 1989-11-16 1992-02-25 The Salk Institute For Biological Studies Beta retinoic acid response elements compositions and assays
US5401629A (en) * 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
EP0688361B1 (en) 1993-03-08 2004-10-13 Merck & Co., Inc. Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
WO1995013299A1 (en) * 1993-11-08 1995-05-18 The Salk Institute Biotechnology/Industrial Associates, Inc. Human neuronal nicotinic acetylcholine receptor compositions and methods employing same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990010648A1 (en) * 1989-03-14 1990-09-20 The Salk Institute For Biological Studies Neuronal nicotinic acetylcholine receptor compositions containing the beta4 subunit
WO1991015602A1 (en) * 1990-04-03 1991-10-17 The Salk Institute Biotechnology/Industrial Associates, Inc. Human neuronal nicotinic acetylcholine receptor compositions and methods employing same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ELLIOTT K;URRUTIA A;JOHNSON E;WILLIAMS M E;ELLIS S B;VELICELEBI G;HARPOLD M M;: "Cloning and functional expression of human neuronal nicotinic acetylcholine receptor subunit alpha-2, alpha-3, alpha-4, alpha-7, beta-2 and beta-4", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 19, no. 1-3, November 1993 (1993-11-01), pages 69 *
SÉGUÉLA, P. ET AL.: "Molecular cloning, functional properties, and distribution of rat brain alpha 7 : a nicotinic cation channel highly permeable to calcium", THE JOURNAL OF NEUROSCIENCE, vol. 13, no. 2, February 1993 (1993-02-01), pages 596 - 604 *
TARRONI, P. ET AL.;: "Neuronal-type nicotinic receptors in human neuroblastoma and small-cell lung carcinoma cell lines", FEBS LETTERS., vol. 312, no. 1, November 1992 (1992-11-01), AMSTERDAM NL, pages 66 - 70 *

Also Published As

Publication number Publication date
ATE279516T1 (en) 2004-10-15
ES2229216T3 (en) 2005-04-16
CA2155330A1 (en) 1994-09-15
JPH08507441A (en) 1996-08-13
US5910582A (en) 1999-06-08
US5837489A (en) 1998-11-17
US6664375B2 (en) 2003-12-16
JP2004194667A (en) 2004-07-15
US6022704A (en) 2000-02-08
CA2155330C (en) 2002-01-29
EP0688361A1 (en) 1995-12-27
GB2286397B (en) 1997-09-10
EP0688361B1 (en) 2004-10-13
WO1994020617A2 (en) 1994-09-15
GB2286397A (en) 1995-08-16
DE69434067D1 (en) 2004-11-18
GB9503688D0 (en) 1995-04-12
US6303753B1 (en) 2001-10-16
AU6517394A (en) 1994-09-26
US20020111463A1 (en) 2002-08-15
AU694424B2 (en) 1998-07-23
DE69434067T2 (en) 2006-03-02
EP1508614A1 (en) 2005-02-23
JP3628691B2 (en) 2005-03-16
GB2286397C (en) 1997-09-10

Similar Documents

Publication Publication Date Title
WO1994020617A3 (en) Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
AU5298293A (en) Chimeric factor viii
AU3530589A (en) Osteogenic devices
AU693747B2 (en) Imidazo(4,5-c)pyridin-4-amines
EP0853121A3 (en) Human DNase
AU6266496A (en) Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
IL88151A0 (en) Interleukin-7,its preparation and compositions containing it
GB2287941A (en) Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
AU8209187A (en) Hybrid proteins
GB8813055D0 (en) Novel substance
EP0337479A3 (en) Method for preparation of zeolites
GR3022080T3 (en) T-cell receptor gene located within alpha locus and dna constructions
AU8045294A (en) Methods for producing protein C
WO1993003148A3 (en) Tau/neurofilament protein kinases pk40 and pk36
PL313257A1 (en) Novel tripeptides useful in treating immune system and central nervous system
MX9700255A (en) METHOD FOR IDENTIFYING NUCLEIC ACIDS ENCODING c-fos PROMOTER ACTIVATING PROTEINS.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AT AU BB BG BR BY CA CH CN CZ DE DK ES FI GB GE HU JP KG KP KR KZ LK LU LV MD MG MN MW NL NO NZ PL PT RO RU SD SE SI SK TJ UA US UZ VN

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

AK Designated states

Kind code of ref document: A3

Designated state(s): AT AU BB BG BR BY CA CH CN CZ DE DK ES FI GB GE HU JP KG KP KR KZ LK LU LV MD MG MN MW NL NO NZ PL PT RO RU SD SE SI SK TJ UA US UZ VN

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2155330

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 1994912758

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1994912758

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWG Wipo information: grant in national office

Ref document number: 1994912758

Country of ref document: EP