WO1994020085A1 - Methods and compositions for inhibition of angiogenesis - Google Patents
Methods and compositions for inhibition of angiogenesis Download PDFInfo
- Publication number
- WO1994020085A1 WO1994020085A1 PCT/US1994/001971 US9401971W WO9420085A1 WO 1994020085 A1 WO1994020085 A1 WO 1994020085A1 US 9401971 W US9401971 W US 9401971W WO 9420085 A1 WO9420085 A1 WO 9420085A1
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- Prior art keywords
- angiogenesis
- human
- animal
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- compound
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- 0 *C(CCC(*1*)=O)C1=O Chemical compound *C(CCC(*1*)=O)C1=O 0.000 description 3
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- General Chemical & Material Sciences (AREA)
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- Epidemiology (AREA)
- Oncology (AREA)
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- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
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Abstract
Description
Claims
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ262676A NZ262676A (en) | 1993-03-01 | 1994-02-24 | Method of inhibiting angiogenesis in a non-human animal using thalidomide and analogues thereof |
DE122008000044C DE122008000044I2 (en) | 1993-03-01 | 1994-02-24 | |
JP6520046A JPH08507767A (en) | 1993-03-01 | 1994-02-24 | Methods and compositions for inhibiting angiogenesis |
CA002157288A CA2157288C (en) | 1993-03-01 | 1994-02-24 | Methods and compositions for inhibition of angiogenesis |
DK94909773T DK0688211T3 (en) | 1993-03-01 | 1994-02-24 | Thalidomide for inhibiting angiogenesis |
DE69430796T DE69430796T2 (en) | 1993-03-01 | 1994-02-24 | THALIDOMID FOR INHIBITING ANGIOGENESIS |
AT94909773T ATE218865T1 (en) | 1993-03-01 | 1994-02-24 | THALIDOMIDE TO INHIBIT ANGIOGENESIS |
KR1019950703700A KR100506043B1 (en) | 1993-03-01 | 1994-02-24 | Compositions to Inhibit Vascular Formation |
AU62486/94A AU676722B2 (en) | 1993-03-01 | 1994-02-24 | Methods and compositions for inhibition of angiogenesis |
EP94909773A EP0688211B1 (en) | 1993-03-01 | 1994-02-24 | Thalidomide for inhibition of angiogenesis |
FR08C0036C FR08C0036I2 (en) | 1993-03-01 | 2008-08-01 | |
LU91471C LU91471I2 (en) | 1993-03-01 | 2008-08-20 | Thalidomide to inhibit angiogenesis |
NL300358C NL300358I2 (en) | 1993-03-01 | 2008-09-01 | Thalidomide for inhibition of angiogenesis. |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2504693A | 1993-03-01 | 1993-03-01 | |
US08/168,817 | 1993-12-15 | ||
US08/168,817 US5629327A (en) | 1993-03-01 | 1993-12-15 | Methods and compositions for inhibition of angiogenesis |
US08/025,046 | 1993-12-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1994020085A1 true WO1994020085A1 (en) | 1994-09-15 |
Family
ID=26699202
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1994/001971 WO1994020085A1 (en) | 1993-03-01 | 1994-02-24 | Methods and compositions for inhibition of angiogenesis |
Country Status (20)
Country | Link |
---|---|
US (18) | US5629327A (en) |
EP (4) | EP1245229A3 (en) |
JP (4) | JPH08507767A (en) |
KR (1) | KR100506043B1 (en) |
AT (2) | ATE218865T1 (en) |
AU (1) | AU676722B2 (en) |
BR (1) | BR9400764A (en) |
CA (3) | CA2342974C (en) |
CO (1) | CO4230017A1 (en) |
DE (3) | DE69430796T2 (en) |
DK (2) | DK1264597T3 (en) |
ES (2) | ES2245711T3 (en) |
FR (1) | FR08C0036I2 (en) |
HK (1) | HK1052865A1 (en) |
LU (1) | LU91471I2 (en) |
NL (1) | NL300358I2 (en) |
NZ (4) | NZ535671A (en) |
PE (1) | PE10095A1 (en) |
PT (1) | PT688211E (en) |
WO (1) | WO1994020085A1 (en) |
Cited By (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0688771A1 (en) * | 1994-06-24 | 1995-12-27 | Grünenthal GmbH | Use of lactam compounds as pharmaceutical agents |
EP0770390A1 (en) * | 1995-11-01 | 1997-05-02 | Dott Research Laboratory | Nasally administrable compositions containing physiologically active peptides |
WO1998003502A1 (en) * | 1996-07-24 | 1998-01-29 | Celgene Corporation | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and method of reducing tnf-alpha levels |
WO1998019649A2 (en) * | 1996-11-05 | 1998-05-14 | The Children's Medical Center Corporation | Methods and compositions for inhibition of angiogenesis |
WO1998054170A1 (en) * | 1997-05-30 | 1998-12-03 | Celgene Corporation | SUBSTITUTED 2-(2,6-DIOXOPIPERIDIN-3-YL)-PHTHALIMIDES AND 1-OXOISOINDOLINES AND METHOD OF REDUCING TNFα LEVELS |
US5858991A (en) * | 1997-01-29 | 1999-01-12 | Vanderbilt University | Facilitation of wound healing with CM101/GBS toxin |
WO1999046258A1 (en) * | 1998-03-13 | 1999-09-16 | Celgene Corporation | SUBSTITUTED 2-(2,6-DIOXO-3-FLUOROPIPERIDIN-3-YL)-ISOINDOLINES AND THEIR USE TO REDUCE TNFα LEVELS |
US5981508A (en) * | 1997-01-29 | 1999-11-09 | Vanderbilt University | Facilitation of repair of neural injury with CM101/GBS toxin |
WO1999058096A2 (en) | 1998-05-11 | 1999-11-18 | Entremed, Inc. | Analogs of 2-phthalimidinoglutaric acid and their use as inhibitors of angiogenesis |
US6028060A (en) * | 1997-01-29 | 2000-02-22 | Vanderbilt University | Treatment of chronic inflammatory diseases with CM101/GBS toxin |
WO2000041547A2 (en) * | 1999-01-13 | 2000-07-20 | The Rockefeller University | Methods of promoting or enhancing interleukin-12 production through administration of thalidomide |
US6114355A (en) * | 1993-03-01 | 2000-09-05 | D'amato; Robert | Methods and compositions for inhibition of angiogenesis |
EP1040838A1 (en) * | 1999-03-31 | 2000-10-04 | Grünenthal GmbH | Stable aqueous EM 12 solution |
US6228879B1 (en) | 1997-10-16 | 2001-05-08 | The Children's Medical Center | Methods and compositions for inhibition of angiogenesis |
US6380239B1 (en) | 1999-03-18 | 2002-04-30 | Celgene Corporation | Substituted 1-oxo- and 1,3-dioxoisoindoline and method of reducing inflammatory cytokine levels |
US6420414B1 (en) | 1993-03-01 | 2002-07-16 | The Children's Medical Center Corporation | Amino derivatives of EM-138 and methods of treating angiogenesis with same |
EP1226824A1 (en) * | 2001-01-24 | 2002-07-31 | TTY Biopharm Company Limited | Use of thalidomide for the treatment of hepatocellular carcinoma |
EP1308444A1 (en) * | 1997-11-18 | 2003-05-07 | Celgene Corporation | Substituted 2-(2,6-Dioxo-3-Fluoropiperidine-3-YL)-Isoindolines and their use to reduce TNF-alpha Levels |
US6670337B1 (en) | 1998-01-29 | 2003-12-30 | Yeda Reaearch And Development Co., Ltd. | Facilitation of wound healing with CM101/GBS toxin |
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- 1994-02-24 NZ NZ535671A patent/NZ535671A/en not_active IP Right Cessation
- 1994-02-24 DE DE69434490T patent/DE69434490T2/en not_active Expired - Lifetime
- 1994-02-24 JP JP6520046A patent/JPH08507767A/en not_active Withdrawn
- 1994-02-24 NZ NZ535670A patent/NZ535670A/en not_active IP Right Cessation
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- 1994-02-24 EP EP94909773A patent/EP0688211B1/en not_active Expired - Lifetime
- 1994-02-24 NZ NZ336527A patent/NZ336527A/en not_active IP Right Cessation
- 1994-02-24 AT AT02011928T patent/ATE304356T1/en not_active IP Right Cessation
- 1994-02-24 DE DE122008000044C patent/DE122008000044I2/de active Active
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- 1994-02-24 KR KR1019950703700A patent/KR100506043B1/en not_active IP Right Cessation
- 1994-02-24 ES ES94909773T patent/ES2174873T3/en not_active Expired - Lifetime
- 1994-02-24 CA CA002157288A patent/CA2157288C/en not_active Expired - Lifetime
- 1994-03-01 PE PE1994237564A patent/PE10095A1/en not_active Application Discontinuation
- 1994-03-01 CO CO94008093A patent/CO4230017A1/en unknown
- 1994-03-01 BR BR9400764A patent/BR9400764A/en not_active Application Discontinuation
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1995
- 1995-01-13 US US08/371,987 patent/US5593990A/en not_active Expired - Lifetime
- 1995-06-06 US US08/468,792 patent/US5712291A/en not_active Ceased
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1997
- 1997-08-22 US US08/918,610 patent/US6235756B1/en not_active Expired - Lifetime
- 1997-10-16 US US08/950,673 patent/US6071948A/en not_active Expired - Lifetime
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2000
- 2000-04-07 US US09/545,139 patent/US6469045B1/en not_active Expired - Fee Related
- 2000-11-09 US US09/710,533 patent/US6420414B1/en not_active Expired - Lifetime
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2001
- 2001-02-26 JP JP2001050214A patent/JP4065373B2/en not_active Expired - Lifetime
- 2001-07-05 US US09/899,318 patent/US20010056113A1/en not_active Abandoned
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- 2001-10-24 US US10/001,183 patent/US20020119956A1/en not_active Abandoned
- 2001-12-12 US US10/015,252 patent/US20020052398A1/en not_active Abandoned
- 2001-12-19 US US10/026,037 patent/US6977268B2/en not_active Expired - Fee Related
- 2001-12-20 US US10/026,291 patent/US20020061911A1/en not_active Abandoned
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2002
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- 2002-12-13 US US10/319,389 patent/US20030187024A1/en not_active Abandoned
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2003
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2004
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2005
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2006
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2008
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