WO1994016101A3 - Dna sequencing by mass spectrometry - Google Patents

Dna sequencing by mass spectrometry Download PDF

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Publication number
WO1994016101A3
WO1994016101A3 PCT/US1994/000193 US9400193W WO9416101A3 WO 1994016101 A3 WO1994016101 A3 WO 1994016101A3 US 9400193 W US9400193 W US 9400193W WO 9416101 A3 WO9416101 A3 WO 9416101A3
Authority
WO
WIPO (PCT)
Prior art keywords
mass spectrometry
mass
chain
nucleoside triphosphates
dna sequencing
Prior art date
Application number
PCT/US1994/000193
Other languages
French (fr)
Other versions
WO1994016101A2 (en
Inventor
Hubert Koester
Original Assignee
Hubert Koester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hubert Koester filed Critical Hubert Koester
Priority to AT94906047T priority Critical patent/ATE267877T1/en
Priority to JP6516209A priority patent/JPH08509857A/en
Priority to EP94906047A priority patent/EP0679196B1/en
Priority to AU59929/94A priority patent/AU694940C/en
Priority to DE69433811T priority patent/DE69433811T2/en
Publication of WO1994016101A2 publication Critical patent/WO1994016101A2/en
Publication of WO1994016101A3 publication Critical patent/WO1994016101A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6872—Methods for sequencing involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G01N35/1067—Multiple transfer devices for transfer to or from containers having different spacing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Abstract

The invention describes a new method to sequence DNA. The improvements over the existing DNA sequencing technologies are high speed, high throughput, no electrophoresis and gel reading artifacts due to the complete absence of an electrophoretic step, and no costly reagents involving various substitutions with stable isotopes. The invention utilizes the Sanger sequencing strategy and assembles the sequence information by analysis of the nested fragments obtained by base-specific chain termination via their different molecular masses using mass spectrometry, as for example, MALDI or ES mass spectrometry. A further increase in throughpout can be obtained by introducing mass-modifications in the oligonucleotide primer, chain-terminating nucleoside triphosphates and/or in the chain-elongating nucleoside triphosphates, as well as using integrated tag sequences which allow multiplexing by hybridization of tag specific probes with mass-differentiated molecular weights.
PCT/US1994/000193 1993-01-07 1994-01-06 Dna sequencing by mass spectrometry WO1994016101A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AT94906047T ATE267877T1 (en) 1993-01-07 1994-01-06 DNA SEQUENCING THROUGH MASS SPECTRONOMY
JP6516209A JPH08509857A (en) 1993-01-07 1994-01-06 DNA sequencing method by mass spectrometry
EP94906047A EP0679196B1 (en) 1993-01-07 1994-01-06 Dna sequencing by mass spectrometry
AU59929/94A AU694940C (en) 1993-01-07 1994-01-06 DNA sequencing by mass spectrometry
DE69433811T DE69433811T2 (en) 1993-01-07 1994-01-06 DNA SEQUENCING BY MASS SPECTROMONY

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US132393A 1993-01-07 1993-01-07
US08/001,323 1993-01-07

Publications (2)

Publication Number Publication Date
WO1994016101A2 WO1994016101A2 (en) 1994-07-21
WO1994016101A3 true WO1994016101A3 (en) 1994-11-24

Family

ID=21695451

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/000193 WO1994016101A2 (en) 1993-01-07 1994-01-06 Dna sequencing by mass spectrometry

Country Status (7)

Country Link
US (3) US5547835A (en)
EP (2) EP0679196B1 (en)
JP (2) JPH08509857A (en)
AT (1) ATE267877T1 (en)
CA (1) CA2153387A1 (en)
DE (1) DE69433811T2 (en)
WO (1) WO1994016101A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
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US7919249B2 (en) 2003-06-30 2011-04-05 Roche Molecular Systems, Inc. 2′-Terminator nucleotide-related methods and systems
US7947817B2 (en) 2003-06-30 2011-05-24 Roche Molecular Systems, Inc. Synthesis and compositions of 2'-terminator nucleotides

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EP1262564A3 (en) 2004-03-31
EP0679196B1 (en) 2004-05-26
US6225450B1 (en) 2001-05-01
EP1262564A2 (en) 2002-12-04
WO1994016101A2 (en) 1994-07-21
AU5992994A (en) 1994-08-15
JP2003230394A (en) 2003-08-19
DE69433811T2 (en) 2005-06-23
AU694940B2 (en) 1998-08-06
CA2153387A1 (en) 1994-07-21
ATE267877T1 (en) 2004-06-15
US5547835A (en) 1996-08-20

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