WO1994012198A1 - Injectable taxol composition - Google Patents
Injectable taxol composition Download PDFInfo
- Publication number
- WO1994012198A1 WO1994012198A1 PCT/AU1993/000599 AU9300599W WO9412198A1 WO 1994012198 A1 WO1994012198 A1 WO 1994012198A1 AU 9300599 W AU9300599 W AU 9300599W WO 9412198 A1 WO9412198 A1 WO 9412198A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- acid
- solution
- taxol
- injectable
- composition according
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU55538/94A AU5553894A (en) | 1992-11-27 | 1993-11-25 | Injectable taxol composition |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPL6074 | 1992-11-27 | ||
AUPL607492 | 1992-11-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1994012198A1 true WO1994012198A1 (en) | 1994-06-09 |
Family
ID=3776561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/AU1993/000599 WO1994012198A1 (en) | 1992-11-27 | 1993-11-25 | Injectable taxol composition |
Country Status (8)
Country | Link |
---|---|
KR (1) | KR100371062B1 (en) |
CN (2) | CN1096673A (en) |
AU (1) | AU5553894A (en) |
IL (2) | IL107776A0 (en) |
IN (1) | IN176188B (en) |
NZ (1) | NZ258044A (en) |
WO (1) | WO1994012198A1 (en) |
ZA (1) | ZA938844B (en) |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2710534A1 (en) * | 1994-09-28 | 1995-04-07 | Bristol Myers Squibb Co | Stabilisation solvent, pharmaceutical composition containing it and process for preparing it |
EP0674510A4 (en) * | 1992-11-27 | 1995-08-12 | Napro Biotherapeutics Inc | Injectable composition. |
NL9500340A (en) * | 1995-02-22 | 1996-10-01 | Yew Tree Pharmaceuticals B V | Stabilized paclitaxel solution and pharmaceutical preparation containing said solution |
ES2095802A1 (en) * | 1993-09-29 | 1997-02-16 | Bristol Myers Squibb Co | Stabilized pharmaceutical composition and stabilizing solvent. |
US5686488A (en) * | 1995-08-25 | 1997-11-11 | Alcon Laboratories, Inc. | Polyethoxylated castor oil products as anti-inflammatory agents |
WO1997041850A1 (en) * | 1996-05-02 | 1997-11-13 | Yeong Wook Song | Paclitaxel for the treatment of rheumatic diseases |
EP0876145A1 (en) * | 1995-12-21 | 1998-11-11 | Genelabs Technologies, Inc. | Taxane composition and method |
WO1998053810A1 (en) * | 1997-05-30 | 1998-12-03 | Man Woo Han | Pharmaceutical injection solution containing taxol |
WO1998057630A1 (en) * | 1997-06-13 | 1998-12-23 | Laboratoires Thissen (L.T.B.) | Pharmaceutical form for administering paclitaxel, method for preparing a ready-for-use paclitaxel composition and thereof |
US6045808A (en) * | 1997-01-31 | 2000-04-04 | Pharmacia & Upjohn Company | Method for removing high boiling solvents from drug formulations by vacuum drying |
WO2000032186A2 (en) * | 1998-12-02 | 2000-06-08 | Mylan Pharmaceuticals, Inc. | Stabilized injectable pharmaceutical compositions containing taxoid anti-neoplastic agents |
KR100330373B1 (en) * | 1996-05-28 | 2002-11-07 | 주식회사한국신약 | Pharmaceutical composition for injection containing taxol |
KR100358934B1 (en) * | 1996-09-13 | 2003-01-29 | 주식회사한국신약 | Pharmaceutical composition of injection containing taxol for |
WO2003022247A1 (en) * | 2001-09-10 | 2003-03-20 | Choongwae Pharma Corporation | Injectable composition of paclitaxel |
US6919370B2 (en) | 2000-11-28 | 2005-07-19 | Transform Pharmaceuticals, Inc. | Pharmaceutical formulations comprising paclitaxel, derivatives, and pharmaceutically acceptable salts thereof |
JP2005534656A (en) * | 2002-06-10 | 2005-11-17 | プリヴァ−ラチェマ アー.エス. | Stabilized pharmaceutical composition based on polyoxyethylated castor oil and process for its production |
EP1904052A1 (en) * | 2005-06-17 | 2008-04-02 | Hospira Australia Pty Ltd | Liquid pharmaceutical formulations of docetaxel |
JP2012072188A (en) * | 2002-06-26 | 2012-04-12 | Medigene Ag | Method for producing cationic liposome comprising lipophilic compound |
US9308180B2 (en) | 2005-08-31 | 2016-04-12 | Abraxis Bioscience, Llc | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
US11529441B2 (en) | 2015-09-15 | 2022-12-20 | W. L. Gore & Associates, Inc. | Drug composition and coating |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19536165A1 (en) * | 1995-09-28 | 1997-04-03 | Basf Ag | Process for cleaning alkoxylated fats |
CN1101677C (en) * | 1997-05-30 | 2003-02-19 | 韩万愚 | Pharmaceutical injection solution containing taxol |
DE10115740A1 (en) * | 2001-03-26 | 2002-10-02 | Ulrich Speck | Preparation for restenosis prophylaxis |
CN101396354B (en) * | 2007-09-30 | 2010-12-01 | 江苏恒瑞医药股份有限公司 | Stable taxabe compound liquid combination and preparation method and use thereof |
CN101829051B (en) * | 2010-05-31 | 2012-09-12 | 南昌弘益科技有限公司 | 1'-acetoxychavicol acetate injection |
CN103432109B (en) * | 2013-09-01 | 2015-09-23 | 吴静 | The pharmaceutical composition of paclitaxel |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990010443A1 (en) * | 1989-03-09 | 1990-09-20 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
EP0428376A1 (en) * | 1989-11-14 | 1991-05-22 | Florida State University | Method for preparation of taxol using an oxazinone |
EP0505047A1 (en) * | 1991-03-18 | 1992-09-23 | Virginia Tech Intellectual Properties, Inc. | Rearranged taxol compounds and method of using in testing of in vivo activity |
US5157049A (en) * | 1988-03-07 | 1992-10-20 | The United States Of America As Represented By The Department Of Health & Human Services | Method of treating cancers sensitive to treatment with water soluble derivatives of taxol |
AU1888792A (en) * | 1991-04-19 | 1992-11-17 | University Of Mississippi, The | Methods and compositions for isolating taxanes |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2601675B1 (en) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | TAXOL DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
NZ224497A (en) * | 1987-05-18 | 1990-04-26 | Janssen Pharmaceutica Nv | Pharmaceutical composition comprising flunarizine |
-
1993
- 1993-11-25 NZ NZ258044A patent/NZ258044A/en not_active IP Right Cessation
- 1993-11-25 KR KR1019940702575A patent/KR100371062B1/en not_active IP Right Cessation
- 1993-11-25 WO PCT/AU1993/000599 patent/WO1994012198A1/en active Application Filing
- 1993-11-25 AU AU55538/94A patent/AU5553894A/en not_active Abandoned
- 1993-11-26 IN IN730CA1993 patent/IN176188B/en unknown
- 1993-11-26 IL IL10777693A patent/IL107776A0/en not_active IP Right Cessation
- 1993-11-26 CN CN93115293A patent/CN1096673A/en active Pending
- 1993-11-26 ZA ZA938844A patent/ZA938844B/en unknown
- 1993-11-27 CN CN93120529A patent/CN1047305C/en not_active Expired - Fee Related
-
1998
- 1998-09-10 IL IL12617898A patent/IL126178A0/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5157049A (en) * | 1988-03-07 | 1992-10-20 | The United States Of America As Represented By The Department Of Health & Human Services | Method of treating cancers sensitive to treatment with water soluble derivatives of taxol |
WO1990010443A1 (en) * | 1989-03-09 | 1990-09-20 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
EP0428376A1 (en) * | 1989-11-14 | 1991-05-22 | Florida State University | Method for preparation of taxol using an oxazinone |
EP0505047A1 (en) * | 1991-03-18 | 1992-09-23 | Virginia Tech Intellectual Properties, Inc. | Rearranged taxol compounds and method of using in testing of in vivo activity |
AU1888792A (en) * | 1991-04-19 | 1992-11-17 | University Of Mississippi, The | Methods and compositions for isolating taxanes |
Cited By (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6306894B1 (en) | 1992-11-27 | 2001-10-23 | Napro Biotherapeutics, Inc. | Injectable composition |
EP0674510A4 (en) * | 1992-11-27 | 1995-08-12 | Napro Biotherapeutics Inc | Injectable composition. |
EP0674510A1 (en) * | 1992-11-27 | 1995-10-04 | Napro Biotherapeutics, Inc. | Injectable composition |
US6140359A (en) * | 1992-11-27 | 2000-10-31 | Napro Biotherapeutics, Inc. | Injectable composition |
EP1500393A1 (en) * | 1992-11-27 | 2005-01-26 | Mayne Pharma (USA) Inc. | Injectable composition containing taxol |
EP1384474A1 (en) * | 1992-11-27 | 2004-01-28 | Napro Biotherapeutics, Inc. | Injectable composition containing taxol |
US5977164A (en) * | 1992-11-27 | 1999-11-02 | Napro Biotherapeutics, Inc. | Stabilized pharmaceutical composition |
EP0835657A1 (en) * | 1992-11-27 | 1998-04-15 | Napro Biotherapeutics, Inc. | Injectable composition |
US5972992A (en) * | 1992-11-27 | 1999-10-26 | Napro Biotherapeutics, Inc. | Injectable composition |
ES2095802A1 (en) * | 1993-09-29 | 1997-02-16 | Bristol Myers Squibb Co | Stabilized pharmaceutical composition and stabilizing solvent. |
FR2710534A1 (en) * | 1994-09-28 | 1995-04-07 | Bristol Myers Squibb Co | Stabilisation solvent, pharmaceutical composition containing it and process for preparing it |
NL9500340A (en) * | 1995-02-22 | 1996-10-01 | Yew Tree Pharmaceuticals B V | Stabilized paclitaxel solution and pharmaceutical preparation containing said solution |
US5686488A (en) * | 1995-08-25 | 1997-11-11 | Alcon Laboratories, Inc. | Polyethoxylated castor oil products as anti-inflammatory agents |
EP0876145A4 (en) * | 1995-12-21 | 1999-04-21 | Genelabs Tech Inc | Taxane composition and method |
EP0876145A1 (en) * | 1995-12-21 | 1998-11-11 | Genelabs Technologies, Inc. | Taxane composition and method |
WO1997041850A1 (en) * | 1996-05-02 | 1997-11-13 | Yeong Wook Song | Paclitaxel for the treatment of rheumatic diseases |
KR100330373B1 (en) * | 1996-05-28 | 2002-11-07 | 주식회사한국신약 | Pharmaceutical composition for injection containing taxol |
KR100358934B1 (en) * | 1996-09-13 | 2003-01-29 | 주식회사한국신약 | Pharmaceutical composition of injection containing taxol for |
US6045808A (en) * | 1997-01-31 | 2000-04-04 | Pharmacia & Upjohn Company | Method for removing high boiling solvents from drug formulations by vacuum drying |
WO1998053810A1 (en) * | 1997-05-30 | 1998-12-03 | Man Woo Han | Pharmaceutical injection solution containing taxol |
BE1011216A3 (en) * | 1997-06-13 | 1999-06-01 | Thissen En Abrege L T B Lab | Pharmaceutical form for the administration of paclitaxel, method of preparation of a composition paclitaxel ready to employment and use thereof. |
WO1998057630A1 (en) * | 1997-06-13 | 1998-12-23 | Laboratoires Thissen (L.T.B.) | Pharmaceutical form for administering paclitaxel, method for preparing a ready-for-use paclitaxel composition and thereof |
WO2000032186A3 (en) * | 1998-12-02 | 2000-11-16 | Mylan Pharmaceuticals Inc | Stabilized injectable pharmaceutical compositions containing taxoid anti-neoplastic agents |
WO2000032186A2 (en) * | 1998-12-02 | 2000-06-08 | Mylan Pharmaceuticals, Inc. | Stabilized injectable pharmaceutical compositions containing taxoid anti-neoplastic agents |
US6919370B2 (en) | 2000-11-28 | 2005-07-19 | Transform Pharmaceuticals, Inc. | Pharmaceutical formulations comprising paclitaxel, derivatives, and pharmaceutically acceptable salts thereof |
US7186751B2 (en) | 2001-09-10 | 2007-03-06 | Choongwae Pharma Corporation | Injectable composition of paclitaxel |
KR100774366B1 (en) * | 2001-09-10 | 2007-11-08 | 주식회사 중외제약 | Injectable composition of paclitaxel |
WO2003022247A1 (en) * | 2001-09-10 | 2003-03-20 | Choongwae Pharma Corporation | Injectable composition of paclitaxel |
JP2005534656A (en) * | 2002-06-10 | 2005-11-17 | プリヴァ−ラチェマ アー.エス. | Stabilized pharmaceutical composition based on polyoxyethylated castor oil and process for its production |
JP2012072188A (en) * | 2002-06-26 | 2012-04-12 | Medigene Ag | Method for producing cationic liposome comprising lipophilic compound |
EP1904052A1 (en) * | 2005-06-17 | 2008-04-02 | Hospira Australia Pty Ltd | Liquid pharmaceutical formulations of docetaxel |
EP2138164A1 (en) * | 2005-06-17 | 2009-12-30 | Hospira Australia Pty Ltd | Liquid pharmaceutical formulations of docetaxel |
EP2308467A3 (en) * | 2005-06-17 | 2011-06-22 | Hospira Australia Pty Ltd | Liquid pharmaceutical formulations of docetaxel |
EP1904052A4 (en) * | 2005-06-17 | 2008-12-10 | Hospira Australia Pty Ltd | Liquid pharmaceutical formulations of docetaxel |
US9308180B2 (en) | 2005-08-31 | 2016-04-12 | Abraxis Bioscience, Llc | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
US11529441B2 (en) | 2015-09-15 | 2022-12-20 | W. L. Gore & Associates, Inc. | Drug composition and coating |
Also Published As
Publication number | Publication date |
---|---|
IN176188B (en) | 1996-02-24 |
CN1047305C (en) | 1999-12-15 |
AU5196793A (en) | 1994-06-09 |
CN1095266A (en) | 1994-11-23 |
NZ258044A (en) | 1995-12-21 |
IL107776A0 (en) | 1994-02-27 |
CN1096673A (en) | 1994-12-28 |
ZA938844B (en) | 1994-08-02 |
AU5553894A (en) | 1994-06-22 |
IL126178A0 (en) | 1999-05-09 |
AU667142B2 (en) | 1996-03-07 |
KR100371062B1 (en) | 2003-04-21 |
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