WO1994008655A3 - Ultrasonic transdermal drug delivery system - Google Patents

Ultrasonic transdermal drug delivery system Download PDF

Info

Publication number
WO1994008655A3
WO1994008655A3 PCT/US1993/009798 US9309798W WO9408655A3 WO 1994008655 A3 WO1994008655 A3 WO 1994008655A3 US 9309798 W US9309798 W US 9309798W WO 9408655 A3 WO9408655 A3 WO 9408655A3
Authority
WO
WIPO (PCT)
Prior art keywords
transducer
ultrasonic
skin
drug delivery
drug
Prior art date
Application number
PCT/US1993/009798
Other languages
French (fr)
Other versions
WO1994008655B1 (en
WO1994008655A2 (en
Inventor
Lev M Lipkovker
Original Assignee
Endodermic Medical Tech
Lev M Lipkovker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endodermic Medical Tech, Lev M Lipkovker filed Critical Endodermic Medical Tech
Priority to EP93923872A priority Critical patent/EP0684856A1/en
Priority to AU53591/94A priority patent/AU678781B2/en
Priority to JP6510246A priority patent/JPH08502424A/en
Publication of WO1994008655A2 publication Critical patent/WO1994008655A2/en
Publication of WO1994008655A3 publication Critical patent/WO1994008655A3/en
Publication of WO1994008655B1 publication Critical patent/WO1994008655B1/en
Priority to KR1019950701445A priority patent/KR950703383A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

Abstract

A transdermal drug delivery system that uses ultrasonic energy to release a stored drug and forcibly move the drug through the skin of an organism into the blood stream of the organism is disclosed. The transdermal drug delivery system includes a housing (81) having a cavity (67) for storing the drug to be delivered. The cavity is defined by an assembly of ultrasonic transducers (65) and is separated from the skin by a polymeric membrane (69). The ultrasonic transducer assembly includes a flat, circular ultrasonic transducer (85) that defines the top of a truncated cone and a plurality of transducer segments (87a, 87b, 87c, 87d...) that define the walls of the cone. The resonant frequency of the planar transducer is lower than the resonant frequency of the transducer segments. Located between the transducer assembly and the cavity is a drug-impermeable laminate (77) that also functions as a focusing lens for the transducers. Control electronics (63) and a power source (61) are also stored in the housing. In operation, the planar, flat, circular transducer generates fixed frequency (5KHz-1MHz range) ultrasonic stimuli impulses for a predetermined period of time (10-20 seconds). Between the stimuli pulse periods, the transducer segments receive variable frequency ultrasonic pumping pulses. The transducer segments create beams that impinge on the skin at an oblique angle and create a pulsating wave. A skin temperature sensor is included to prevent the ultrasonic signals from overheating the skin. The system may also include an infrared (IR) or laser transducer for enhancing the operation of the drug delivery system by heating the skin and creating additional ultrasonic waves. Both open loop and closed loop (feedback) versions are provided. The closed loop version includes a sensor for sensing drug delivery effectiveness and using the resulting information to control the rate of drug delivery. The sensor uses ultrasonic energy to remove fluid from the skin for analysis.
PCT/US1993/009798 1992-10-14 1993-10-13 Ultrasonic transdermal drug delivery system WO1994008655A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP93923872A EP0684856A1 (en) 1992-10-14 1993-10-13 Ultrasonic transdermal drug delivery system
AU53591/94A AU678781B2 (en) 1992-10-14 1993-10-13 Ultrasonic transdermal drug delivery system
JP6510246A JPH08502424A (en) 1992-10-14 1993-10-13 Ultrasonic transdermal drug delivery system
KR1019950701445A KR950703383A (en) 1992-10-14 1995-04-14 ULTRASONIC TRANSDERMAL DRUG DELIVERY SYSTEM

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/961,113 1992-10-14
US07/961,113 US5421816A (en) 1992-10-14 1992-10-14 Ultrasonic transdermal drug delivery system

Publications (3)

Publication Number Publication Date
WO1994008655A2 WO1994008655A2 (en) 1994-04-28
WO1994008655A3 true WO1994008655A3 (en) 1994-09-01
WO1994008655B1 WO1994008655B1 (en) 1994-09-15

Family

ID=25504075

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/009798 WO1994008655A2 (en) 1992-10-14 1993-10-13 Ultrasonic transdermal drug delivery system

Country Status (7)

Country Link
US (2) US5421816A (en)
EP (1) EP0684856A1 (en)
JP (1) JPH08502424A (en)
KR (1) KR950703383A (en)
AU (1) AU678781B2 (en)
CA (1) CA2146010A1 (en)
WO (1) WO1994008655A2 (en)

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US9125979B2 (en) 2007-10-25 2015-09-08 Proteus Digital Health, Inc. Fluid transfer port information system

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AU678781B2 (en) 1997-06-12
CA2146010A1 (en) 1994-04-28
EP0684856A1 (en) 1995-12-06
US5617851A (en) 1997-04-08
AU5359194A (en) 1994-05-09
KR950703383A (en) 1995-09-20
US5421816A (en) 1995-06-06
WO1994008655A2 (en) 1994-04-28
JPH08502424A (en) 1996-03-19

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