WO1994006492A1 - Accumulator for implantable pump - Google Patents
Accumulator for implantable pump Download PDFInfo
- Publication number
- WO1994006492A1 WO1994006492A1 PCT/US1993/006775 US9306775W WO9406492A1 WO 1994006492 A1 WO1994006492 A1 WO 1994006492A1 US 9306775 W US9306775 W US 9306775W WO 9406492 A1 WO9406492 A1 WO 9406492A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- accumulator
- diaphragm
- chamber
- pressure
- spring
- Prior art date
Links
- 239000012530 fluid Substances 0.000 claims abstract description 51
- 238000012546 transfer Methods 0.000 claims abstract description 33
- 238000001802 infusion Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 description 15
- 239000003814 drug Substances 0.000 description 15
- 125000006850 spacer group Chemical group 0.000 description 12
- 239000000463 material Substances 0.000 description 7
- 239000007789 gas Substances 0.000 description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 239000011261 inert gas Substances 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 230000009977 dual effect Effects 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 101100327917 Caenorhabditis elegans chup-1 gene Proteins 0.000 description 1
- 230000005355 Hall effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000006920 protein precipitation Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16877—Adjusting flow; Devices for setting a flow rate
- A61M5/16881—Regulating valves
Definitions
- This invention relates to an implantable infusion system.
- it relates to an improvement in an infusate accumulator used with a valve system in such a system operating at positive pressure to dispense medication in accordance with different specified flow rates.
- a drug reservoir 10 is refillable by means of a septum 12.
- the reservoir comprises a sealed housing 14 containing a bellows element 16 having a chamber 18 which comprises the drug reservoir.
- the bellows 16 separates the housing 14 into a second zone 20 which is normally filled with a two-phase fluid.
- the fluid normally Freon, vaporizes and compresses the bellows 16 thus providing a release pressure to the reservoir 18 through the outlet leading to the infusion site.
- the two-phase fluid is then pressurized condensing a portion of the vapor and returning it to the liquid phase.
- Such systems also employ an outlet filter 24 and a side port 27 for direct bolus injections.
- the reservoir and fluid delivery techniques are well established in constant flow systems.
- an accumulator 30 has been proposed for use in a number of applications.
- a metering assembly comprising two normally closed valves 26 and 28. Interposed between the two valves is an accumulator 30.
- the valves 26 and 28 are controlled electronically by the module 32 which may be programmed utilizing an external programmer 34.
- valve 26 In operation of such a system, a constant positive pressure flow from the reservoir 10 to the inlet valve 26 occurs. Valve 26 is opened while the outlet valve 28 is closed. This loads the accumulator 30 with a predetermined amount of medication. The valve 26 is then closed and outlet valve 28 opened so that the contents of the accumulator 30 are delivered to the catheter 36 for delivery to the infusate site.
- the rate of switching of the valves 26 and 28 thus determines the frequency of pumping through the system and therefore determines the delivery rate of medication through the catheter 36. For each cycle a constant amount equal to the accumulator volume is delivered.
- the accumulator 30 has two alternative forms as illustrated in Figs. 2 and 3.
- Figs. 2 and 3 utilize the same numbering as in the '887 patent.
- the inlet is represented by numeral 58 wherein fluid enters the accumulator from the inlet valve 26.
- the accumulator comprises a diaphragm 90, a backing plate 92, an end cap 94, a fill tube 96 and a spacer plate 98.
- the diaphragm 90 deflects in response to fluid entry of the chamber 102.
- the backing plate 92 acts as a mechanical stop to limit motion of the diaphragm.
- the spacer plate 98 is used to limit diaphragm motion during discharge, that is, the passage of fluid through the outlet 59.
- spacer plate 98 as a mechanical stop creates a problem when fragile materials such as insulin are used.
- the material is locally compressed and crushed by the mechanical action of the diaphragm contacting the stop. This breaks down the fluid. Since the internal volumes are quite small, this in turn can result in residue formation inside the accumulator.
- the fill tube 96 is used to supply an inert gas to the chamber 104.
- the purpose of chamber 104 is to provide a region which is charged at a pressure lower than that of the infusate pressure in drug reservoir 18 so that accumulator chamber 102 fills when inlet valve 26 is opened, but higher in pressure than that of the catheter 36 to allow the diaphragm 90 to deflect back to the spacer plate 98 position as the chamber 102 empties when the outlet valve 28 is opened. Additional details of this accumulator may be found in U.S. Patent 4,838,887.
- Figure 3 illustrates an alternative configuration.
- the backing plate 92 comprises three elements which electrically isolate the center of the plate from the diaphragm 90.
- a supply of inert gas is still supplied via the feed fill tube 96.
- a lead 110 is attached to a flange forming a portion of the end cap assembly.
- a ceramic cup 1 13, which is lined with metal 1 1 1 provides a conductive path between a stop 114 and the lead 110.
- the diaphragm 90 is used as a moving switch contact. This provides a signal indicating that the accumulator is full, that is, the diaphragm in an upward position contacting the stop 114. This electrical signal is used for diagnostic determinations of the system such as leaks in the valve.
- valve accumulator systems discussed herein function in a satisfactory manner and provide for an accurate metering of flow.
- one difficulty common to all valve systems is damage to the fluid passing through it as a consequence of interaction with valves, diaphragms and the like.
- various types of insulin are particularly sensitive to mechanically induced damage which tends to break down that material. This in turn causes a build-up of precipitate at the very location in the system, the accumulator, where metering accuracy is desired. Over time clogging can occur.
- Yet another object of this invention is to provide an accumulator configuration having minimal size to thereby reduce the overall packaging of implantable medical devices.
- a still further object of this invention is to provide an accumulator which does not utilize ' mechanical stops or spacer plate contact in the infusate path, thereby minimizing fluid contact points.
- a spring biased pressure plate may be used or, as an alternative to the transfer fluid, a chamfered slider element may be used.
- Fig. 1 is a schematic diagram illustrating a complete implantable system which employs an accumulator as described in U.S. Patent 4,838,887;
- Fig. 2 is a schematic cut-away side view of an accumulator as described in U.S. Patent 4,838,887;
- Fig. 3 is a schematic cut-away side view of a modified accumulator illustrated in U.S. Patent 4,838,887;
- Fig. 4 is a schematic side view of an accumulator in accordance with the first preferred embodiment of this invention.
- Fig. 5 is a schematic cut-away side view of an accumulator in accordance with a second preferred embodiment of this invention.
- Fig. 6 is a schematic cut-away side view of an accumulator in accordance with a third preferred embodiment of this invention.
- Fig. 7 is a schematic cut-away view of a fourth preferred embodiment of this invention. Description of the Invention
- the accumulator of Fig. 4 also includes an intermediate member 45 with flow passages 45a and surface grooves 45b, which defines a transfer fluid chamber 46.
- the presence of the surface grooves 45b is to allow the fluid to lift the diaphragm quicker thus decreasing the response time to fill from empty.
- the transfer fluid chamber 46 is separated from the drug chamber 41 by means of a first diaphragm 47.
- the transfer fluid chamber 46 is filled with transfer fluid 46a via a fill tube 48 which is sealed after the transfer fluid chamber 46 has been loaded.
- the transfer fluid 46a may be any incompressible, low vapor pressure fluid such as silicone oil, water, or other material which can be used hydraulically to transfer the pressure difference which exists across first diaphragm 47 through flow passages 45a to a second diaphragm 52.
- the second diaphragm 52 has a constant back pressure bias based on the pressure in cavity 50.
- a backing plate 49 defines the cavity 50 which is filled with an inert gas such as Argon loaded to 4 psig, utilizing the fill tube 51 as illustrated.
- This pressure can urge second diaphragm 52 downward, displacing the transfer fluid 46a in transfer fluid chamber 46 against first diaphragm 47, forcing a reduction in volume of drug chamber 41.
- the first diaphragm 47 displaces as a function of the pressure difference between that which exists in the drug chamber 41 and in the transfer fluid chamber 46.
- the input pressure in chamber 41 is greater than the pressure of transfer fluid 46a as biased by the gas in cavity 50.
- first diaphragm 47 deflects upward which in turn causes second diaphragm 52 to deflect upward.
- the volume in chamber 46 remains constant since the transfer fluid 46a is incompressible.
- chamber 41 empties as first diaphragm 47 and second diaphragm 52 deflect downward.
- first diaphragm 47 is not controlled by any mechanical stops. Instead, its motion is limited by the volume of transfer fluid 46a displaced in cavity 46 which in turn is limited by the displacement of second diaphragm 52.
- the position of second diaphragm 52 is maintained by backing plate 49 and intermediate member 45.
- FIG. 5 illustrates a second preferred embodiment of this invention.
- like components are designated with the same numerals as in Fig. 4. To the extent that those items function in a similar manner, they will not be discussed with respect to this second preferred embodiment.
- Figure 5 departs from Fig. 4 in several respects.
- a substantially rigid spacer disc 60 having perforations is used in the transfer fluid chamber 46.
- the perforated disc has a series of holes to allow fluid communication between upper and lower surfaces thereof.
- the purpose of the disc 60 is to provide mechanical limit stops to both the first and second diaphragms 47 and 52, respectively.
- the disc 60 has a surface texture characteristic such as micromachined flow channels or is roughened to provide a random flow pattern. Such is desired to decrease the response time of the system in a fashion similar to the use of surface grooves 45b of Fig. 4. That is, the valves need not be held in an open state longer than needed thus reducing battery power requirements.
- a third preferred embodiment of this invention is depicted.
- a chamfered slider 70 is used in place of the perforated disc 60 of the second preferred embodiment.
- the slider 70 is positioned in a chamber 46' and it is located between diaphragms 47 and 52.
- the slider 70 is a transfer medium functioning much like transfer fluid 46a.
- Chamber 46' is like fluid chamber 46 and it can include transfer fluid 46a. in this embodiment, transfer fluid is not required in chamber 46' but it can be included, if desired.
- the slider 70 employs contoured surfaces 72 and 74 on the upper and lower surfaces respectively. As illustrated in Fig.
- FIG. 7 A fourth preferred embodiment is illustrated in Fig. 7.
- the second diaphragm is in the form of an elastomeric diaphragm 80.
- the elastomeric diaphragm 80 is clamped in place between the end cap 49 and a pressure spring adjustment member 82 which is threaded into place in a manner similar to that illustrated in Fig. 5.
- a push pin 84 is spring biased by means of spring 86.
- the position of the pressure spring adjustment member 82 sets the span between a head or end plate 85 of the push pin 84 and the upper flange 83 on adjustment member 82. This compresses the spring 86 which varies the back pressure on the pin and thus sets the position of the elastomeric diaphragm 80.
- the head 85 of the push pin 84 is also limited in motion by the lower flange 87 on backing plate 49.
- Figure 7 illustrates the use of a perforated screen 88. This is an optional element for purposes of safety to limit the upward deflection of the first diaphragm 47. It is however not required.
- the transfer fluid 46a would be loaded into the transfer fluid chamber 46 or chamber 46' in a manner identical to that of Fig. 4. It is apparent from the description of the preferred embodiments herein that other modifications may be practiced without departing from the essential scope of this invention.
- the spacer elements such as perforated disc 60, can be cantilevered elements and not a perforated disc.
- a woven element or a porous plug could be substituted for perforated disc 60.
- Absolute rigidity is required in any case so that the diaphragm is supported.
- the slider 70 of Fig. 6 could be modified to include level sensing in the chamber 41 as a function of slider 70 position. This would be done by Hall effect, capacitive pick-up or metallic contact. By placing the sensor in the wall of intermediate member 45, the position of the slider 70 can be determined. The slider 70 would also be given a texture on surfaces contacting the first and second diaphragms 47 and 52, respectively, to increase flow-thru characteristics thus reducing power requirements.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69308578T DE69308578T2 (en) | 1992-09-18 | 1993-07-22 | MEMORY FOR IMPLANTABLE PUMP |
DE9390324U DE9390324U1 (en) | 1992-09-18 | 1993-07-22 | Pressure accumulator for implantable pumps |
AU46840/93A AU674332B2 (en) | 1992-09-18 | 1993-07-22 | Accumulator for implantable pump |
EP93917277A EP0660728B1 (en) | 1992-09-18 | 1993-07-22 | Accumulator for implantable pump |
CA002142980A CA2142980C (en) | 1992-09-18 | 1993-07-22 | Accumulator for implantable pump |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/946,848 | 1992-09-18 | ||
US07/946,848 US5281210A (en) | 1992-09-18 | 1992-09-18 | Accumulator for implantable pump |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1994006492A1 true WO1994006492A1 (en) | 1994-03-31 |
Family
ID=25485062
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1993/006775 WO1994006492A1 (en) | 1992-09-18 | 1993-07-22 | Accumulator for implantable pump |
Country Status (9)
Country | Link |
---|---|
US (1) | US5281210A (en) |
EP (1) | EP0660728B1 (en) |
JP (1) | JP2744136B2 (en) |
AT (1) | ATE149356T1 (en) |
AU (1) | AU674332B2 (en) |
CA (1) | CA2142980C (en) |
DE (2) | DE9390324U1 (en) |
ES (1) | ES2099461T3 (en) |
WO (1) | WO1994006492A1 (en) |
Families Citing this family (35)
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CA2151407A1 (en) * | 1995-06-09 | 1996-12-10 | Duncan Newman | Injection device |
US6270326B1 (en) | 1997-08-29 | 2001-08-07 | Seiko Epson Corporation | Transfusion device and liquid supply tube |
US6203523B1 (en) * | 1998-02-02 | 2001-03-20 | Medtronic Inc | Implantable drug infusion device having a flow regulator |
US6048328A (en) * | 1998-02-02 | 2000-04-11 | Medtronic, Inc. | Implantable drug infusion device having an improved valve |
US6090062A (en) * | 1998-05-29 | 2000-07-18 | Wayne State University | Programmable antisiphon shunt system |
EP1356837A1 (en) * | 1998-06-18 | 2003-10-29 | Medical Research Group, Inc. | Medical infusion device with a source of controlled compliance |
WO1999065540A2 (en) * | 1998-06-18 | 1999-12-23 | Medical Research Group, Inc. | Medical infusion device with a source of controlled compliance |
US6471675B1 (en) * | 1999-04-30 | 2002-10-29 | Medtronic, Inc. | Passive flow control devices for implantable pumps |
US6635049B1 (en) * | 1999-04-30 | 2003-10-21 | Medtronic, Inc. | Drug bolus delivery system |
US6471689B1 (en) * | 1999-08-16 | 2002-10-29 | Thomas Jefferson University | Implantable drug delivery catheter system with capillary interface |
US6764472B1 (en) * | 2000-01-11 | 2004-07-20 | Bard Access Systems, Inc. | Implantable refillable infusion device |
US20040073175A1 (en) * | 2002-01-07 | 2004-04-15 | Jacobson James D. | Infusion system |
JP4565193B2 (en) | 2003-04-23 | 2010-10-20 | バレリタス, インコーポレイテッド | Hydraulically operated pump for long duration pharmaceutical administration |
EP1635894B1 (en) * | 2003-06-25 | 2015-05-27 | Infusion Systems, LLC | Medication infusion device using negatively biased ambient pressure medication chamber |
US9089636B2 (en) | 2004-07-02 | 2015-07-28 | Valeritas, Inc. | Methods and devices for delivering GLP-1 and uses thereof |
US20060116648A1 (en) * | 2004-07-26 | 2006-06-01 | Bret Hamatake | Port design and method of assembly |
US8100889B2 (en) * | 2004-11-10 | 2012-01-24 | Olympus Corporation | Body-insertable apparatus |
EP2005309B1 (en) | 2006-03-30 | 2016-02-17 | Valeritas, Inc. | Multi-cartridge fluid delivery device |
US8251960B2 (en) | 2007-03-24 | 2012-08-28 | The Alfred E. Mann Foundation For Scientific Research | Valves, valved fluid transfer devices and ambulatory infusion devices including the same |
US8740861B2 (en) | 2007-03-24 | 2014-06-03 | Medallion Therapeutics, Inc. | Valves, valved fluid transfer devices and ambulatory infusion devices including the same |
US20080234639A1 (en) * | 2007-03-24 | 2008-09-25 | David Christopher Antonio | Valves, Valved Fluid Transfer Devices and Ambulatory Infusion Devices Including The Same |
US8273058B2 (en) | 2007-10-04 | 2012-09-25 | Flowonix Medical Incorporated | Two way accumulator programmable valve pump |
US8551044B2 (en) * | 2008-03-05 | 2013-10-08 | Flowonix Medical Incorporated | Multiple reservoir implantable drug infusion device and method |
US20100042213A1 (en) * | 2008-08-13 | 2010-02-18 | Nebosky Paul S | Drug delivery implants |
WO2010019807A1 (en) * | 2008-08-13 | 2010-02-18 | Smed-Ta/Td, Llc | Orthopaedic implant with spatially varying porosity |
US10842645B2 (en) | 2008-08-13 | 2020-11-24 | Smed-Ta/Td, Llc | Orthopaedic implant with porous structural member |
US9700431B2 (en) | 2008-08-13 | 2017-07-11 | Smed-Ta/Td, Llc | Orthopaedic implant with porous structural member |
JP5774989B2 (en) * | 2008-08-13 | 2015-09-09 | スメド−ティーエイ/ティーディー・エルエルシー | Orthopedic screw |
US9616205B2 (en) | 2008-08-13 | 2017-04-11 | Smed-Ta/Td, Llc | Drug delivery implants |
EP2341852B1 (en) * | 2008-08-29 | 2018-08-15 | SMed-TA/TD, LLC | Orthopaedic implant |
US20110166522A1 (en) * | 2010-01-06 | 2011-07-07 | Medtronic, Inc. | Accumulator for therapeutic fluid delivery devices |
US8545484B2 (en) | 2011-10-18 | 2013-10-01 | Medtronic, Inc. | Accumulator for implantable infusion device |
KR102250698B1 (en) * | 2019-05-13 | 2021-05-12 | 주식회사 필로시스 | Method and device to inject medicine |
US11745003B2 (en) | 2020-10-30 | 2023-09-05 | Medtronic, Inc. | Implantable access port with one-directional filter |
US11931545B2 (en) | 2020-10-30 | 2024-03-19 | Medtronic, Inc. | Drug infusion port |
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FR2354106A1 (en) * | 1976-06-11 | 1978-01-06 | Siemens Ag | NEW DOSER THAT CAN BE IMPLANTED |
FR2370184A1 (en) * | 1976-11-09 | 1978-06-02 | Nikkiso Co Ltd | PULSATORY PUMP FOR BLOOD CIRCULATION |
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DE3634725A1 (en) * | 1986-10-11 | 1988-04-14 | Holzer Walter | Dosing pump, e.g. for insulin |
EP0410125A1 (en) * | 1989-07-27 | 1991-01-30 | Tetra Dev-Co | Piston unit with rolling membrane |
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US4299220A (en) * | 1979-05-03 | 1981-11-10 | The Regents Of The University Of Minnesota | Implantable drug infusion regulator |
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DE3577039D1 (en) * | 1984-06-21 | 1990-05-17 | David R Fischell | FINGER-ACTUATED INFUSION SYSTEM FOR THE MEDICAL SUPPLY. |
US4838887A (en) * | 1987-12-15 | 1989-06-13 | Shiley Infusaid Inc. | Programmable valve pump |
US4820273A (en) * | 1988-03-01 | 1989-04-11 | Eaton Corporation | Implantable medication infusion device and bolus generator therefor |
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AT391416B (en) * | 1988-06-23 | 1990-10-10 | Annemarie Schloegl Ges M B H M | SEPTUM FOR IMPLANTABLE DEVICES FOR DELIVERING ACTIVE SUBSTANCES |
US5137529A (en) * | 1990-02-20 | 1992-08-11 | Pudenz-Schulte Medical Research Corporation | Injection port |
US5049141A (en) * | 1990-04-25 | 1991-09-17 | Infusaid, Inc. | Programmable valve pump |
US5090963A (en) * | 1990-10-19 | 1992-02-25 | Product Development (Z.G.S.) Ltd. | Electrochemically driven metering medicament dispenser |
-
1992
- 1992-09-18 US US07/946,848 patent/US5281210A/en not_active Expired - Lifetime
-
1993
- 1993-07-22 ES ES93917277T patent/ES2099461T3/en not_active Expired - Lifetime
- 1993-07-22 DE DE9390324U patent/DE9390324U1/en not_active Expired - Lifetime
- 1993-07-22 AU AU46840/93A patent/AU674332B2/en not_active Ceased
- 1993-07-22 EP EP93917277A patent/EP0660728B1/en not_active Expired - Lifetime
- 1993-07-22 WO PCT/US1993/006775 patent/WO1994006492A1/en active IP Right Grant
- 1993-07-22 AT AT93917277T patent/ATE149356T1/en not_active IP Right Cessation
- 1993-07-22 DE DE69308578T patent/DE69308578T2/en not_active Expired - Lifetime
- 1993-07-22 CA CA002142980A patent/CA2142980C/en not_active Expired - Fee Related
- 1993-07-22 JP JP6508065A patent/JP2744136B2/en not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2354106A1 (en) * | 1976-06-11 | 1978-01-06 | Siemens Ag | NEW DOSER THAT CAN BE IMPLANTED |
FR2370184A1 (en) * | 1976-11-09 | 1978-06-02 | Nikkiso Co Ltd | PULSATORY PUMP FOR BLOOD CIRCULATION |
US4443218A (en) * | 1982-09-09 | 1984-04-17 | Infusaid Corporation | Programmable implantable infusate pump |
US4714462A (en) * | 1986-02-03 | 1987-12-22 | Intermedics Infusaid, Inc. | Positive pressure programmable infusion pump |
DE3634725A1 (en) * | 1986-10-11 | 1988-04-14 | Holzer Walter | Dosing pump, e.g. for insulin |
EP0410125A1 (en) * | 1989-07-27 | 1991-01-30 | Tetra Dev-Co | Piston unit with rolling membrane |
Also Published As
Publication number | Publication date |
---|---|
AU674332B2 (en) | 1996-12-19 |
DE69308578D1 (en) | 1997-04-10 |
AU4684093A (en) | 1994-04-12 |
US5281210A (en) | 1994-01-25 |
ATE149356T1 (en) | 1997-03-15 |
ES2099461T3 (en) | 1997-05-16 |
EP0660728B1 (en) | 1997-03-05 |
DE69308578T2 (en) | 1997-06-12 |
JP2744136B2 (en) | 1998-04-28 |
DE9390324U1 (en) | 1995-09-14 |
CA2142980C (en) | 1999-10-05 |
CA2142980A1 (en) | 1994-03-31 |
EP0660728A1 (en) | 1995-07-05 |
JPH07509168A (en) | 1995-10-12 |
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