WO1994004120A3 - Methods of treating sexual dysfunction in animals with and h agonist - Google Patents

Methods of treating sexual dysfunction in animals with and h agonist Download PDF

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Publication number
WO1994004120A3
WO1994004120A3 PCT/BR1993/000027 BR9300027W WO9404120A3 WO 1994004120 A3 WO1994004120 A3 WO 1994004120A3 BR 9300027 W BR9300027 W BR 9300027W WO 9404120 A3 WO9404120 A3 WO 9404120A3
Authority
WO
WIPO (PCT)
Prior art keywords
pct
agonist
sexual dysfunction
animals
methods
Prior art date
Application number
PCT/BR1993/000027
Other languages
French (fr)
Other versions
WO1994004120A2 (en
Inventor
Roberto Dias Nahoum Cesar
Original Assignee
Roberto Dias Nahoum Cesar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roberto Dias Nahoum Cesar filed Critical Roberto Dias Nahoum Cesar
Priority to AU49371/93A priority Critical patent/AU678996C/en
Priority to JP50569694A priority patent/JP2002510277A/en
Priority to AT93918819T priority patent/ATE233091T1/en
Priority to KR1019950700672A priority patent/KR100331754B1/en
Priority to EP93918819A priority patent/EP0655914B1/en
Priority to CA002142875A priority patent/CA2142875A1/en
Priority to US08/381,945 priority patent/US5908853A/en
Priority to DE69332713T priority patent/DE69332713D1/en
Publication of WO1994004120A2 publication Critical patent/WO1994004120A2/en
Publication of WO1994004120A3 publication Critical patent/WO1994004120A3/en
Priority to NZ255278A priority patent/NZ255278A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

PCT No. PCT/BR93/00027 Sec. 371 Date Feb. 15, 1995 Sec. 102(e) Date Feb. 15, 1995 PCT Filed Aug. 18, 1993 PCT Pub. No. WO94/04120 PCT Pub. Date Mar. 3, 1994The present invention involves the novel use of H2 and H3 agonists, as erectogenic agents in the treatment of male and female sexual dysfunction in an animal, including humans. The H2 and H3 agonists may be administered by intracavernousm injection, topically, transdermally, or intraurethrally. The method of use may also include a second therapeutic agent which either facilitates, potentiates or is erectogenic. The second agent may be administered sequentially or contemporaneously with either the H2 or H3 agonist.
PCT/BR1993/000027 1992-08-21 1993-08-18 Methods of treating sexual dysfunction in animals with and h agonist WO1994004120A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU49371/93A AU678996C (en) 1992-08-21 1993-08-18 Method of treating sexual dysfunction in animals with an H agonist
JP50569694A JP2002510277A (en) 1992-08-21 1993-08-18 New composition
AT93918819T ATE233091T1 (en) 1992-08-21 1993-08-18 USE OF HISTAMINE-2 AGONISTS TO TREAT SEXUAL DISORDERS
KR1019950700672A KR100331754B1 (en) 1992-08-21 1993-08-18 Pharmaceutical compositions for the treatment of erectile dysfunction or insensitivity in animals
EP93918819A EP0655914B1 (en) 1992-08-21 1993-08-18 Use of Histamine-2 agonists for treatment of sexual dysfunction
CA002142875A CA2142875A1 (en) 1992-08-21 1993-08-18 The use of h2 and h3 agonists to treat sexual dysfunction
US08/381,945 US5908853A (en) 1992-08-21 1993-08-18 Compositions
DE69332713T DE69332713D1 (en) 1992-08-21 1993-08-18 Use of histamine-2 agonists to treat sexual dysfunction
NZ255278A NZ255278A (en) 1992-08-21 1995-02-15 Treatment of sexual dysfunction using an h2 agonist (heterocyclic substituted n-methyl thioethyl guanidine or aminopropylisothiourea derivatives)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BR929203277A BR9203277A (en) 1992-08-21 1992-08-21 USE OF ERETOGENIC DRUGS AND THEIR APPLICATION METHODOLOGIES
BR920,3277 1992-08-21

Publications (2)

Publication Number Publication Date
WO1994004120A2 WO1994004120A2 (en) 1994-03-03
WO1994004120A3 true WO1994004120A3 (en) 1994-05-26

Family

ID=4054796

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BR1993/000027 WO1994004120A2 (en) 1992-08-21 1993-08-18 Methods of treating sexual dysfunction in animals with and h agonist

Country Status (13)

Country Link
US (1) US5908853A (en)
EP (1) EP0655914B1 (en)
JP (1) JP2002510277A (en)
KR (1) KR100331754B1 (en)
AT (1) ATE233091T1 (en)
BR (1) BR9203277A (en)
CA (1) CA2142875A1 (en)
DE (1) DE69332713D1 (en)
NZ (1) NZ255278A (en)
OA (1) OA10251A (en)
TW (1) TW418090B (en)
WO (1) WO1994004120A2 (en)
ZA (1) ZA936118B (en)

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US20050065161A1 (en) * 1996-02-02 2005-03-24 Nitromed, Inc. Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
GB9608408D0 (en) * 1996-04-23 1996-06-26 Adams Michael A Treatment of erectile dysfunction
FR2748658B1 (en) * 1996-05-15 2000-08-18 Biotec Centre Sa USE OF "ALPHA-BLOCKING" COMPOUNDS, PARTICULARLY MOXISYLYTE AND / OR DERIVATIVES THEREOF FOR THE TREATMENT OF ERECTILE DYSFUNCTIONS BY BALAN TRANSMUCOSAL ROUTE
GR1002847B (en) * 1997-05-06 1998-01-27 Use of micropostol and/or micropostol acid for the preparation of a medicine for the therapeutic treatiment of problems related to the erection
DE19728103A1 (en) * 1997-07-02 1999-01-07 Winfried Dr Med Heinicke Composition for treatment of erectile dysfunction
US20020004529A1 (en) * 1997-10-20 2002-01-10 Gary W. Neal Methods, compositions, and kits for enhancing female sexual desire and responsiveness
ZA989513B (en) * 1997-10-21 1999-04-21 Alcon Lab Inc Compositions containing histamine H2 agonists and methods of use in treating dry eye
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
GB9802078D0 (en) * 1998-01-30 1998-03-25 Futura Medical Limited Preparation for treatment of erectile dysfunction
FR2774593B1 (en) * 1998-02-12 2000-05-05 Philippe Gorny OBTAINING A MEDICINE TO COMBAT FEMALE SEXUAL DYSFUNCTIONS
US6011043A (en) * 1998-06-19 2000-01-04 Schering Corporation Combination of phentolamine and apomorphine for the treatment of human sexual function and dysfunction
GR1003199B (en) 1998-08-14 1999-09-01 Use of micropostol and/or micropostol acid for the preparation of a medicine for the therapeutic threatment of problemes related to the female sexual malfunction
FR2786699B1 (en) * 1998-12-02 2002-10-04 Philippe Gorny MEDICINE, IN PARTICULAR FOR PREVENTING OR TREATING SEXUAL DYSFUNCTIONS
US20070191320A1 (en) * 1998-12-10 2007-08-16 Nexmed Holdings, Inc. Methods of treatment for female sexual arousal disorder
US6825234B2 (en) 1998-12-10 2004-11-30 Nexmed (Holdings) , Inc. Compositions and methods for amelioration of human female sexual dysfunction
US6486207B2 (en) 1998-12-10 2002-11-26 Nexmed (Holdings), Inc. Compositions and methods for amelioration of human female sexual dysfunction
US6762202B2 (en) 2000-05-09 2004-07-13 Nitromed, Inc. Infrared thermography and methods of use
EP1292618B1 (en) * 2000-05-22 2005-10-19 Ramot at Tel Aviv University Ltd. Vip-related peptides for the treatment of sexual disorders in women
WO2002064212A1 (en) * 2001-02-13 2002-08-22 Cornell Research Foundation, Inc. Method and compositions for reducing cardiac dysfunctions with a selective histamine h3 receptor agonist
AU2003221845A1 (en) * 2002-04-10 2003-10-27 Nathan Andrew Shapira Methods of treating medication-, substance-, disease-, and other medical condition-related sexual dysfunction
US6841574B2 (en) * 2003-01-03 2005-01-11 Nexmed Holdings, Inc. Topical stabilized prostaglandin E compound dosage forms
US7622844B1 (en) * 2003-12-30 2009-11-24 Hipercon, Llc Metal fiber brush interface conditioning
US20060013769A1 (en) * 2004-07-16 2006-01-19 Stephen Carter Transdermal drug delivery formulations and method of determining optimal amounts of vasodilators therein
US10010494B2 (en) 2005-10-19 2018-07-03 Menni Menashe Zinger Methods for the treatment of hyperhidrosis
US20090197892A1 (en) * 2007-08-21 2009-08-06 Nawaz Ahmad Anhydrous compositions useful for attaining enhanced sexual wellness
US9034389B2 (en) * 2009-03-11 2015-05-19 Stable Solutions Llc Omega-3 enriched fish oil-in-water parenteral nutrition emulsions
US8993625B2 (en) 2009-03-11 2015-03-31 Stable Solutions Llc Method of mitigating adverse drug events using omega-3 fatty acids as a parenteral therapeutic drug vehicle
US20140121256A1 (en) * 2012-10-26 2014-05-01 Beech Tree Labs, Inc. Method of treating muscular weakness comprising administering a composition comprising an effective amount of histamine and/or serotonin
US10463699B2 (en) 2016-04-04 2019-11-05 Omeza LLC Fish oil topical composition

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Also Published As

Publication number Publication date
CA2142875A1 (en) 1994-03-03
JP2002510277A (en) 2002-04-02
EP0655914A1 (en) 1995-06-07
BR9203277A (en) 1994-03-01
DE69332713D1 (en) 2003-04-03
AU4937193A (en) 1994-03-15
WO1994004120A2 (en) 1994-03-03
US5908853A (en) 1999-06-01
ATE233091T1 (en) 2003-03-15
KR100331754B1 (en) 2002-10-04
AU678996B2 (en) 1997-06-19
NZ255278A (en) 1999-05-28
EP0655914A4 (en) 1998-04-22
KR950702823A (en) 1995-08-23
TW418090B (en) 2001-01-11
OA10251A (en) 1997-10-07
ZA936118B (en) 1995-04-20
EP0655914B1 (en) 2003-02-26

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