WO1993023434A3 - Bpi-immunoglobulin fusion proteins - Google Patents
Bpi-immunoglobulin fusion proteins Download PDFInfo
- Publication number
- WO1993023434A3 WO1993023434A3 PCT/US1993/004754 US9304754W WO9323434A3 WO 1993023434 A3 WO1993023434 A3 WO 1993023434A3 US 9304754 W US9304754 W US 9304754W WO 9323434 A3 WO9323434 A3 WO 9323434A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- proteins
- fusion proteins
- bpi
- disclosed
- immunoglobulin fusion
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4742—Bactericidal/Permeability-increasing protein [BPI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/033—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the internal surface of the plasma membrane, e.g. containing a myristoylation motif
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88591192A | 1992-05-19 | 1992-05-19 | |
US07/885,911 | 1992-05-19 | ||
CN93109046A CN1096821A (en) | 1992-05-19 | 1993-06-21 | The BPI-immunoglobulin fusion proteins |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1993023434A2 WO1993023434A2 (en) | 1993-11-25 |
WO1993023434A3 true WO1993023434A3 (en) | 1994-01-06 |
Family
ID=36822331
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1993/004754 WO1993023434A2 (en) | 1992-05-19 | 1993-05-19 | Bpi-immunoglobulin fusion proteins |
Country Status (4)
Country | Link |
---|---|
US (1) | US5643570A (en) |
CN (1) | CN1096821A (en) |
AU (1) | AU4382193A (en) |
WO (1) | WO1993023434A2 (en) |
Families Citing this family (54)
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US6265187B1 (en) * | 1989-02-14 | 2001-07-24 | Incyte Pharmaceuticals, Inc. | Recombinant endotoxin-neutralizing proteins |
US6103888A (en) * | 1992-07-17 | 2000-08-15 | Panorama Research, Inc. | Mammalian cationic proteins having lipopolysaccharide binding and anti-coagulant activity |
US5420019A (en) * | 1993-02-02 | 1995-05-30 | Xoma Corporation | Stable bactericidal/permeability-increasing protein muteins |
CA2155005C (en) | 1993-02-02 | 1999-04-06 | Weldon Courtney Mcgregor | Pharmaceutical compositions containing bactericidal permeability increasing protein and a surfactant |
US5652332A (en) * | 1993-03-12 | 1997-07-29 | Xoma | Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof |
US5627153A (en) * | 1994-01-14 | 1997-05-06 | Xoma Corporation | Anti-fungal methods and materials |
US6214789B1 (en) | 1993-03-12 | 2001-04-10 | Xoma Corporation | Treatment of mycobacterial diseases by administration of bactericidal/permeability-increasing protein products |
CA2161971A1 (en) * | 1993-04-30 | 1994-11-10 | Randal W. Scott | Recombinant bpi-based and lbp-based proteins, nucleic acid molecules encoding same, methods of producing same, and uses thereof |
US5731415A (en) * | 1993-06-17 | 1998-03-24 | Xoma Corporation | Lipopolysaccharide binding protein derivatives |
WO1995002414A1 (en) * | 1993-07-14 | 1995-01-26 | Xoma Corporation | Method for potentiating bpi protein product bactericidal activity by administration of lbp protein products |
US5770561A (en) * | 1993-07-14 | 1998-06-23 | Xoma Corporation | Method for potentiating BPI protein product bactericidal activity by administration of LBP protein products |
US6759203B1 (en) | 1993-09-22 | 2004-07-06 | Xoma Corporation | Method for quantifying BPI in body fluids |
CN1133634A (en) * | 1993-09-22 | 1996-10-16 | 爱克斯欧玛公司 | Method for quantifying BPI in body fluids |
DE69430823T2 (en) * | 1993-09-22 | 2003-02-20 | Xoma Technology Ltd | METHOD FOR TREATING GRAM-NEGATIVE BACTERIA INFECTION BY ADMINISTERING BACTERIA-KILLING / PLEASUREABILITY (BPI) PROTEIN PRODUCT AND ANTIBIOTIC |
US5578572A (en) * | 1994-01-14 | 1996-11-26 | Xoma Corporation | Anti-gram-positive bacterial methods and materials |
US5447913A (en) * | 1994-03-11 | 1995-09-05 | Xoma Corporation | Therapeutic uses of bactericidal/permeability-increasing protein dimer products |
US5786324A (en) * | 1994-03-24 | 1998-07-28 | Regents Of The University Of Minnesota | Synthetic peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use |
US5830860A (en) * | 1994-03-24 | 1998-11-03 | Regents Of The University Of Minnesota | Peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use |
US5578568A (en) | 1994-04-22 | 1996-11-26 | Xoma Corporation | Method of treating conditions associated with intestinal ischemia/reperfusion |
US5932544A (en) * | 1994-05-31 | 1999-08-03 | Xoma Corporation | Bactericidal/permeability-increasing protein (BPI) compositions |
US6271203B1 (en) | 1994-07-07 | 2001-08-07 | Xoma Corporation | Anti-protozoan methods and materials |
US5646114A (en) * | 1994-07-11 | 1997-07-08 | Xoma Corporation | Anti-protozoan methods |
US5494896A (en) * | 1995-03-31 | 1996-02-27 | Xoma Corporation | Method of treating conditions associated with burn injuries |
WO1997004008A1 (en) * | 1995-07-20 | 1997-02-06 | Xoma Corporation | Anti-fungal peptides |
DK0914144T3 (en) | 1996-05-10 | 2001-04-09 | Univ Texas | Therapeutic uses of BPI protein products for human meningococcemia |
US5741779A (en) * | 1996-05-10 | 1998-04-21 | Xoma Corporation | Antithrombotic materials and methods |
CN1155403C (en) * | 1996-05-23 | 2004-06-30 | 爱克索马技术有限公司 | Therapeutic uses of BPI protein products in humans with hemorrhage due to trauma |
JP2000511892A (en) | 1996-05-24 | 2000-09-12 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | Synthesis of soluble beta-sheet forming peptide |
US5888973A (en) * | 1996-08-09 | 1999-03-30 | Xoma Corporation | Anti-chlamydial uses of BPI protein products |
AUPO280796A0 (en) * | 1996-10-07 | 1996-10-31 | Austin Research Institute, The | Methods of activating or enhancing FC receptors |
US6482796B2 (en) | 1996-11-01 | 2002-11-19 | Xoma Corporation | Therapeutic uses of N-terminal BPI protein products in ANCA-positive patients |
US6093573A (en) * | 1997-06-20 | 2000-07-25 | Xoma | Three-dimensional structure of bactericidal/permeability-increasing protein (BPI) |
US6013631A (en) * | 1998-06-19 | 2000-01-11 | Xoma Corporation | Bactericidal/permeability-increasing protein (BPI) deletion analogs |
TR200504220T2 (en) * | 1998-12-17 | 2007-04-24 | Biogen Idec Ma Inc. | Active lymphotoxin-beta receptor immunoglobulin chime A method for high level expression and purification of purified protein proteins and a method for purification of active lymphotoxin-beta receptor immunoglobulin chimeric proteins. |
US20030106084A1 (en) * | 2000-03-29 | 2003-06-05 | Yang Liu | Methods of blocking tissue destruction by autoreactive T cells |
AU2001253158A1 (en) * | 2000-04-05 | 2001-10-23 | University Of Tennessee Research Corporation | Methods of investigating, diagnosing, and treating amyloidosis |
CA2430588A1 (en) * | 2000-12-01 | 2002-07-18 | Xoma Technology Ltd. | Modulation of pericyte proliferation using bpi protein products or bpi inhibitors |
US20050214290A1 (en) * | 2001-03-29 | 2005-09-29 | Yang Liu | Methods of blocking tissue destruction by autoreactive T cells |
JP2005536453A (en) | 2002-02-20 | 2005-12-02 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | Partial peptide mimetics and methods |
EP1492874B1 (en) | 2002-03-29 | 2011-01-19 | XOMA Technology Ltd. | Multigenic vector plasmids and methods for increasing expression of recombinant polypeptides |
US7304139B2 (en) * | 2003-10-28 | 2007-12-04 | University Of Florida Research Foundation, Inc. | Polynucleotides and polypeptides of Anaplasma phagocytophilum and methods of using the same |
US8080245B2 (en) * | 2004-08-04 | 2011-12-20 | University Of Massachusetts | Anti-pathogen immunoadhesins |
CN1733911A (en) * | 2004-08-13 | 2006-02-15 | 首都医科大学 | Recombinant virus containing BPI gene and pharmaceutical composition containing same and uses |
US20060241040A1 (en) * | 2005-04-06 | 2006-10-26 | Alberto Visintin | Methods of treating disorders associated with toll-like receptor 4 (TLR4) signalling |
EP1741440A1 (en) | 2005-07-08 | 2007-01-10 | Mellitus S.L. | Use of BPI protein for the treatment of disorders of the metabolism and cardiovascular disorders |
US7888069B2 (en) * | 2006-12-22 | 2011-02-15 | Dow Agrosciences Llc | Plant-made west nile virus (WNV) vaccines, vectors and plant codon optimized sequences |
EP2164868B1 (en) | 2007-05-04 | 2015-03-25 | Technophage, Investigação E Desenvolvimento Em Biotecnologia, SA | Engineered rabbit antibody variable domains and uses thereof |
CN101717449B (en) * | 2008-10-09 | 2013-06-19 | 重庆富进生物医药有限公司 | Recombinant TRAIL-Fc fusion protein as well as preparation and application thereof |
CA2814673A1 (en) | 2010-10-15 | 2012-04-19 | Purdue Research Foundation | Immunoreactive antigens of mycoplasma heamofelis and diagnostic immunoassay |
CN103958542A (en) | 2011-09-23 | 2014-07-30 | 抗菌技术,生物技术研究与发展股份有限公司 | Modified albumin-binding domains and uses thereof to improve pharmacokinetics |
US9399678B2 (en) | 2011-09-23 | 2016-07-26 | Technophage, Investigacao E Desenvolvimento Em Biotecnologia, Sa | Anti-tumor necrosis factor-alpha agents and uses thereof |
US10975131B2 (en) | 2015-10-27 | 2021-04-13 | University Of Massachusetts | Factor H-Fc immunotheraphy |
US10035995B2 (en) | 2015-12-07 | 2018-07-31 | Eastman Chemical Company | CALB variants |
EP3566717A1 (en) * | 2018-05-09 | 2019-11-13 | Universität Regensburg | Bactericidal/permeability increasing protein for use in a method of immunization, preferably as an adjuvant in a method of vaccination |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989001486A1 (en) * | 1987-08-11 | 1989-02-23 | New York University | Biologically active bactericidal/permeability-increasing protein fragments |
EP0464533A1 (en) * | 1990-06-28 | 1992-01-08 | BEHRINGWERKE Aktiengesellschaft | Fusionproteins with parts of immunoglobulins, their production and use |
WO1992003535A1 (en) * | 1990-08-13 | 1992-03-05 | Incyte Pharmaceuticals, Inc. | Recombinant bpi proteins, uses of bpi proteins, and methods of preparing same |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
JPH0611290B2 (en) * | 1986-11-05 | 1994-02-16 | 住友ベークライト株式会社 | Γ-ray sterilization method for polyvinyl alcohol gel |
US5098833A (en) * | 1989-02-23 | 1992-03-24 | Genentech, Inc. | DNA sequence encoding a functional domain of a lymphocyte homing receptor |
US5004839A (en) * | 1989-10-23 | 1991-04-02 | Aristech Chemical Corporation | Preparation of unsaturated ketones from acetone and paraformaldehyde (II) |
US5225341A (en) * | 1990-07-19 | 1993-07-06 | The Regents Of The University Of California | Biologically safe plant transformation system using a ds transposon |
GB9023605D0 (en) * | 1990-10-30 | 1990-12-12 | British Telecomm | Digital radio |
US5420019A (en) * | 1993-02-02 | 1995-05-30 | Xoma Corporation | Stable bactericidal/permeability-increasing protein muteins |
-
1993
- 1993-05-19 US US08/064,693 patent/US5643570A/en not_active Expired - Fee Related
- 1993-05-19 AU AU43821/93A patent/AU4382193A/en not_active Abandoned
- 1993-05-19 WO PCT/US1993/004754 patent/WO1993023434A2/en active Application Filing
- 1993-06-21 CN CN93109046A patent/CN1096821A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989001486A1 (en) * | 1987-08-11 | 1989-02-23 | New York University | Biologically active bactericidal/permeability-increasing protein fragments |
EP0464533A1 (en) * | 1990-06-28 | 1992-01-08 | BEHRINGWERKE Aktiengesellschaft | Fusionproteins with parts of immunoglobulins, their production and use |
WO1992003535A1 (en) * | 1990-08-13 | 1992-03-05 | Incyte Pharmaceuticals, Inc. | Recombinant bpi proteins, uses of bpi proteins, and methods of preparing same |
Also Published As
Publication number | Publication date |
---|---|
WO1993023434A2 (en) | 1993-11-25 |
AU4382193A (en) | 1993-12-13 |
CN1096821A (en) | 1994-12-28 |
US5643570A (en) | 1997-07-01 |
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