WO1993022678A3 - Optical and electrical methods and apparatus for molecule detection - Google Patents

Optical and electrical methods and apparatus for molecule detection Download PDF

Info

Publication number
WO1993022678A3
WO1993022678A3 PCT/US1993/003829 US9303829W WO9322678A3 WO 1993022678 A3 WO1993022678 A3 WO 1993022678A3 US 9303829 W US9303829 W US 9303829W WO 9322678 A3 WO9322678 A3 WO 9322678A3
Authority
WO
WIPO (PCT)
Prior art keywords
optical
molecule detection
test sites
electrical methods
structures
Prior art date
Application number
PCT/US1993/003829
Other languages
French (fr)
Other versions
WO1993022678A2 (en
Inventor
Mark A Hollis
Daniel J Ehrlich
Allen R Murphy
Bernard B Kosicki
Dennis D Rathman
Chang-Lee Chen
Richard H Mathews
Barry E Burke
Mitch D Eggers
Michael E Hogan
Rajender Singh Varma
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25359894&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1993022678(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Priority to DE69333687T priority Critical patent/DE69333687T2/en
Priority to EP93910751A priority patent/EP0638173B1/en
Priority to JP51939693A priority patent/JP3447055B2/en
Publication of WO1993022678A2 publication Critical patent/WO1993022678A2/en
Publication of WO1993022678A3 publication Critical patent/WO1993022678A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6832—Enhancement of hybridisation reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/22—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance
    • G01N27/221—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance by investigating the dielectric properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/22—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance
    • G01N27/226—Construction of measuring vessels; Electrodes therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00511—Walls of reactor vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00709—Type of synthesis
    • B01J2219/00711—Light-directed synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00709—Type of synthesis
    • B01J2219/00713—Electrochemical synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00824—Ceramic
    • B01J2219/00828—Silicon wafers or plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00853—Employing electrode arrangements
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures

Abstract

A method and apparatus are disclosed for identifying molecular structures within a sample substance using a monolithic array of test sites formed on a substrate upon which the sample substance is applied. Each test site includes probes formed therein to bond with a predetermined target molecular structure or structures. A signal is applied to the test sites and certain electrical, mechanical and/or optical properties of the test sites are detected to determine which probes have bonded to an associated target molecular structure.
PCT/US1993/003829 1992-04-23 1993-04-23 Optical and electrical methods and apparatus for molecule detection WO1993022678A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE69333687T DE69333687T2 (en) 1992-04-23 1993-04-23 OPTICAL AND ELECTRICAL METHODS FOR DETERMINING MOLECULES
EP93910751A EP0638173B1 (en) 1992-04-23 1993-04-23 Optical and electrical methods for molecule detection
JP51939693A JP3447055B2 (en) 1992-04-23 1993-04-23 Electrical method and apparatus for molecule detection

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/872,582 1992-04-23
US07/872,582 US5846708A (en) 1991-11-19 1992-04-23 Optical and electrical methods and apparatus for molecule detection

Publications (2)

Publication Number Publication Date
WO1993022678A2 WO1993022678A2 (en) 1993-11-11
WO1993022678A3 true WO1993022678A3 (en) 1994-02-03

Family

ID=25359894

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/003829 WO1993022678A2 (en) 1992-04-23 1993-04-23 Optical and electrical methods and apparatus for molecule detection

Country Status (5)

Country Link
US (2) US5846708A (en)
EP (4) EP1143014B9 (en)
JP (3) JP3447055B2 (en)
DE (2) DE69334108T2 (en)
WO (1) WO1993022678A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7655129B2 (en) 1998-06-23 2010-02-02 Osmetech Technology Inc. Binding acceleration techniques for the detection of analytes
CN101688862A (en) * 2007-06-27 2010-03-31 （株）赛丽康 Diagnosis device using image sensor and method of manufacturing the same
US8012743B2 (en) 1998-10-27 2011-09-06 Osmetech Technology Inc. Detection of target analytes using particles and electrodes
US9151746B2 (en) 1999-04-21 2015-10-06 Osmetech Technology, Inc. Use of microfluidic systems in the electrochemical detection of target analytes

Families Citing this family (816)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6379895B1 (en) 1989-06-07 2002-04-30 Affymetrix, Inc. Photolithographic and other means for manufacturing arrays
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
US6346413B1 (en) 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6406844B1 (en) 1989-06-07 2002-06-18 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US6309822B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US6506558B1 (en) 1990-03-07 2003-01-14 Affymetrix Inc. Very large scale immobilized polymer synthesis
DE69132843T2 (en) 1990-12-06 2002-09-12 Affymetrix Inc N D Ges D Staat Identification of nucleic acids in samples
US6051380A (en) * 1993-11-01 2000-04-18 Nanogen, Inc. Methods and procedures for molecular biological analysis and diagnostics
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US6652808B1 (en) 1991-11-07 2003-11-25 Nanotronics, Inc. Methods for the electronic assembly and fabrication of devices
US5849486A (en) 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US6569382B1 (en) 1991-11-07 2003-05-27 Nanogen, Inc. Methods apparatus for the electronic, homogeneous assembly and fabrication of devices
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US6048690A (en) * 1991-11-07 2000-04-11 Nanogen, Inc. Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
US6017696A (en) 1993-11-01 2000-01-25 Nanogen, Inc. Methods for electronic stringency control for molecular biological analysis and diagnostics
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US6468740B1 (en) * 1992-11-05 2002-10-22 Affymetrix, Inc. Cyclic and substituted immobilized molecular synthesis
US6943034B1 (en) 1991-11-22 2005-09-13 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US5677195A (en) * 1991-11-22 1997-10-14 Affymax Technologies N.V. Combinatorial strategies for polymer synthesis
US6893816B1 (en) 1993-10-28 2005-05-17 Houston Advanced Research Center Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions
US7101661B1 (en) * 1993-11-01 2006-09-05 Nanogen, Inc. Apparatus for active programmable matrix devices
US6331274B1 (en) 1993-11-01 2001-12-18 Nanogen, Inc. Advanced active circuits and devices for molecular biological analysis and diagnostics
US6309602B1 (en) 1993-11-01 2001-10-30 Nanogen, Inc. Stacked, reconfigurable system for electrophoretic transport of charged materials
US6254827B1 (en) 1993-11-01 2001-07-03 Nanogen, Inc. Methods for fabricating multi-component devices for molecular biological analysis and diagnostics
US6129828A (en) 1996-09-06 2000-10-10 Nanogen, Inc. Apparatus and methods for active biological sample preparation
US7314708B1 (en) * 1998-08-04 2008-01-01 Nanogen, Inc. Method and apparatus for electronic synthesis of molecular structures
US5965452A (en) 1996-07-09 1999-10-12 Nanogen, Inc. Multiplexed active biologic array
US6315953B1 (en) 1993-11-01 2001-11-13 Nanogen, Inc. Devices for molecular biological analysis and diagnostics including waveguides
US6638482B1 (en) 1993-11-01 2003-10-28 Nanogen, Inc. Reconfigurable detection and analysis apparatus and method
US20040077074A1 (en) * 1993-11-01 2004-04-22 Nanogen, Inc. Multi-chambered analysis device
US6375899B1 (en) 1993-11-01 2002-04-23 Nanogen, Inc. Electrophoretic buss for transport of charged materials in a multi-chamber system
US6287517B1 (en) 1993-11-01 2001-09-11 Nanogen, Inc. Laminated assembly for active bioelectronic devices
US6306348B1 (en) * 1993-11-01 2001-10-23 Nanogen, Inc. Inorganic permeation layer for micro-electric device
US7582421B2 (en) * 1993-11-01 2009-09-01 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip
US7172864B1 (en) * 1993-11-01 2007-02-06 Nanogen Methods for electronically-controlled enzymatic reactions
US6068818A (en) 1993-11-01 2000-05-30 Nanogen, Inc. Multicomponent devices for molecular biological analysis and diagnostics
US6319472B1 (en) 1993-11-01 2001-11-20 Nanogen, Inc. System including functionally separated regions in electrophoretic system
US6726880B1 (en) 1993-11-01 2004-04-27 Nanogen, Inc. Electronic device for performing active biological operations and method of using same
US6225059B1 (en) 1993-11-01 2001-05-01 Nanogen, Inc. Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
US5591578A (en) * 1993-12-10 1997-01-07 California Institute Of Technology Nucleic acid mediated electron transfer
US5952172A (en) 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
GB9401833D0 (en) * 1994-02-01 1994-03-30 Isis Innovation Method for discovering ligands
US6287850B1 (en) 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
DE69527585T2 (en) * 1994-06-08 2003-04-03 Affymetrix Inc Method and device for packaging chips
US7857957B2 (en) 1994-07-07 2010-12-28 Gamida For Life B.V. Integrated portable biological detection system
US6071394A (en) * 1996-09-06 2000-06-06 Nanogen, Inc. Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis
US6403367B1 (en) 1994-07-07 2002-06-11 Nanogen, Inc. Integrated portable biological detection system
US6379897B1 (en) * 2000-11-09 2002-04-30 Nanogen, Inc. Methods for gene expression monitoring on electronic microarrays
FR2722294B1 (en) * 1994-07-07 1996-10-04 Lyon Ecole Centrale PROCESS FOR THE QUALITATIVE AND / OR QUANTITATIVE ANALYSIS OF BIOLOGICAL SUBSTANCES PRESENT IN A CONDUCTIVE LIQUID MEDIUM AND BIOCHEMICAL AFFINITY SENSORS USED FOR THE IMPLEMENTATION OF THIS PROCESS
WO1996006946A1 (en) * 1994-08-26 1996-03-07 Igen, Inc. Biosensor for and method of electrogenerated chemiluminescent detection of nucleic acid adsorbed to a solid surface
US6558633B1 (en) 1994-09-21 2003-05-06 Isis Pharmaceuticals, Inc. Chemical reaction apparatus and methods
US5814565A (en) * 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
US5959098A (en) * 1996-04-17 1999-09-28 Affymetrix, Inc. Substrate preparation process
US5922534A (en) * 1995-03-28 1999-07-13 Hewlett-Packard Company Dry biochemical assay plate and method for making the same
DE19512117A1 (en) 1995-04-04 1996-10-10 Itt Ind Gmbh Deutsche Measuring device
US6720149B1 (en) * 1995-06-07 2004-04-13 Affymetrix, Inc. Methods for concurrently processing multiple biological chip assays
AU698921B2 (en) * 1995-06-08 1998-11-12 Bayer Healthcare Llc Nanofabricated separation matrix for analysis of biopolymers and methods of making and using same
US6361951B1 (en) 1995-06-27 2002-03-26 The University Of North Carolina At Chapel Hill Electrochemical detection of nucleic acid hybridization
DE69623494T2 (en) * 1995-06-27 2003-04-17 Univ North Carolina ELECTROCHEMICAL DETECTION OF NUCLEIC ACID HYBRIDATION
US6168948B1 (en) 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US20020022261A1 (en) * 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US6110660A (en) * 1995-08-20 2000-08-29 The European Institute Of Science Ab Procedure for quantitative and qualitative determination of chemical substances, based on molecular recognition and measurement of magnetic permeability
US5849208A (en) * 1995-09-07 1998-12-15 Microfab Technoologies, Inc. Making apparatus for conducting biochemical analyses
US20040086917A1 (en) * 1995-09-27 2004-05-06 Nanogen, Inc. Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
US20020068357A1 (en) * 1995-09-28 2002-06-06 Mathies Richard A. Miniaturized integrated nucleic acid processing and analysis device and method
ATE271219T1 (en) * 1995-12-01 2004-07-15 Innogenetics Nv SYSTEM AND METHOD FOR DETERMINING IMPEDANCE AND PRODUCTION PROCESS
US6660233B1 (en) 1996-01-16 2003-12-09 Beckman Coulter, Inc. Analytical biochemistry system with robotically carried bioarray
DE19610115C2 (en) * 1996-03-14 2000-11-23 Fraunhofer Ges Forschung Detection of molecules and molecular complexes
US5721435A (en) * 1996-04-09 1998-02-24 Hewlett Packard Company Methods and apparatus for measuring optical properties of biological and chemical substances
WO1997039145A1 (en) 1996-04-17 1997-10-23 Motorola Inc. Transistor-based molecular detection apparatus and method
US6251691B1 (en) 1996-04-25 2001-06-26 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
US6355436B1 (en) 1996-05-17 2002-03-12 L'ecole Centrale De Lyon Method for analyzing biological substances in a conductive liquid medium
US6444423B1 (en) 1996-06-07 2002-09-03 Molecular Dynamics, Inc. Nucleosides comprising polydentate ligands
SE9602545L (en) * 1996-06-25 1997-12-26 Michael Mecklenburg Method of discriminating complex biological samples
US6235520B1 (en) * 1996-06-27 2001-05-22 Cellstat Technologies, Inc. High-throughput screening method and apparatus
US6582921B2 (en) * 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US5798360A (en) * 1996-08-01 1998-08-25 Isis Pharmaceuticals, Inc. N-(aminoalkyl)- and/or N-(amidoalkyl)- dinitrogen heterocyclic compositions
US5817489A (en) 1996-08-01 1998-10-06 Isis Pharmaceuticals, Inc. Di-nitrogen heterocycle compositions
US5922872A (en) * 1996-08-01 1999-07-13 Isis Pharmaceuticals, Inc. Meta-benzylic and alpha-amido compositions and methods for preparing same
US5731438A (en) * 1996-08-01 1998-03-24 Isis Pharmaceuticals, Inc. N-(aminoalkyl)-and/or N-(amidoalkyl)-dinitrogen heterocycles
US5914613A (en) 1996-08-08 1999-06-22 Cascade Microtech, Inc. Membrane probing system with local contact scrub
US5827482A (en) * 1996-08-20 1998-10-27 Motorola Corporation Transistor-based apparatus and method for molecular detection and field enhancement
WO1998014641A1 (en) * 1996-10-02 1998-04-09 Symyx Technologies Potential masking systems and methods for combinatorial library synthesis
EP1669738A3 (en) 1996-10-09 2007-12-12 Symyx Technologies, Inc. Infrared spectroscopy and imaging of libraries
US7045285B1 (en) 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
US6096273A (en) * 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7160678B1 (en) 1996-11-05 2007-01-09 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7393645B2 (en) 1996-11-05 2008-07-01 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US7014992B1 (en) 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US5780241A (en) 1996-11-05 1998-07-14 Isis Pharmaceuticals, Inc. Complex chemical libraries
WO1998022819A1 (en) * 1996-11-16 1998-05-28 Nmi Naturwissenschaftliches Und Medizinisches Institut An Der Universität Tübingen In Reutlingen Stiftung Bürgerlichen Rechts Array of microelements, method of contacting cells in a liquid environment and method for the production of an array of microelements
US6706473B1 (en) 1996-12-06 2004-03-16 Nanogen, Inc. Systems and devices for photoelectrophoretic transport and hybridization of oligonucleotides
US5804384A (en) * 1996-12-06 1998-09-08 Vysis, Inc. Devices and methods for detecting multiple analytes in samples
NZ335453A (en) * 1996-12-12 2001-07-27 Prolume Ltd Microelectronic device with microlocations including photodetector for detecting bioluminescence
JP4663824B2 (en) * 1996-12-31 2011-04-06 ハイ スループット ジェノミクス インコーポレイテッド Multiplexed molecular analyzer and method
US6306584B1 (en) * 1997-01-21 2001-10-23 President And Fellows Of Harvard College Electronic-property probing of biological molecules at surfaces
US5827748A (en) * 1997-01-24 1998-10-27 The United States Of America As Represented By The Secretary Of The Navy Chemical sensor using two-dimensional lens array
US5954931A (en) * 1997-01-24 1999-09-21 Motorola, Inc. Electrophoresis apparatus and method involving parallel channels
FI970593A (en) * 1997-02-12 1998-08-13 Sakari Mikael Kulmala Use of coated conductors for analytical purposes
US6056859A (en) * 1997-02-12 2000-05-02 Lockheed Martin Energy Research Corporation Method and apparatus for staining immobilized nucleic acids
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
WO1998049344A1 (en) * 1997-04-28 1998-11-05 Lockheed Martin Energy Research Corporation Method and apparatus for analyzing nucleic acids
US6110748A (en) 1997-04-30 2000-08-29 Motorola, Inc. Optical storage medium for binding assays
US5968728A (en) * 1997-04-30 1999-10-19 Motorola, Inc. Molecular detection devices and methods of forming same
US5935785A (en) * 1997-04-30 1999-08-10 Motorola, Inc. Binding assay methods
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US7560237B2 (en) 1997-06-12 2009-07-14 Osmetech Technology Inc. Electronics method for the detection of analytes
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
EP0895083B1 (en) 1997-08-01 2009-09-23 Canon Kabushiki Kaisha Reaction site array, preparation of it, reaction process using it and quantitative determination method of substance in sample solution using it
JP4313861B2 (en) 1997-08-01 2009-08-12 キヤノン株式会社 Manufacturing method of probe array
US6495892B2 (en) 1997-08-08 2002-12-17 California Institute Of Technology Techniques and systems for analyte detection
DE69840951D1 (en) * 1997-08-08 2009-08-13 Cyrano Sciences Inc Arrangement of chemically sensitive capacitors
DE19741715A1 (en) 1997-09-22 1999-03-25 Hoechst Ag New pentopyranosyl nucleoside compounds
DE19742246A1 (en) * 1997-09-25 1999-04-01 Basf Ag Analytical measurement method and its use
US20030104481A1 (en) * 1997-09-30 2003-06-05 Symyx Technologies Potential masking systems and methods for combinatorial library synthesis
US6048692A (en) * 1997-10-07 2000-04-11 Motorola, Inc. Sensors for electrically sensing binding events for supported molecular receptors
US6393895B1 (en) 1997-10-08 2002-05-28 Symyx Technologies, Inc. Method and apparatus for characterizing materials by using a mechanical resonator
US6494079B1 (en) * 2001-03-07 2002-12-17 Symyx Technologies, Inc. Method and apparatus for characterizing materials by using a mechanical resonator
WO1999019510A1 (en) 1997-10-10 1999-04-22 President And Fellows Of Harvard College Surface-bound, double-stranded dna protein arrays
US6511803B1 (en) 1997-10-10 2003-01-28 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6485944B1 (en) 1997-10-10 2002-11-26 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
JP2001519538A (en) 1997-10-10 2001-10-23 プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ Replica amplification of nucleic acid arrays
US5945286A (en) * 1997-10-23 1999-08-31 Motorola, Inc. Electrochemical-based molecular detection apparatus and method
US6013513A (en) * 1997-10-30 2000-01-11 Motorola, Inc. Molecular detection apparatus
US5922617A (en) * 1997-11-12 1999-07-13 Functional Genetics, Inc. Rapid screening assay methods and devices
US6762056B1 (en) 1997-11-12 2004-07-13 Protiveris, Inc. Rapid method for determining potential binding sites of a protein
DE19751658A1 (en) * 1997-11-21 1999-07-29 Wolfbeis Otto S Prof Dr Process for the formation of laterally organized structures on support surfaces
SE520046C2 (en) * 1997-11-24 2003-05-13 Sense Ab Q Method for Measuring Interaction between a Target Molecule and a Receptor Molecule with Piezoelectric Crystal Microwave
US6117643A (en) * 1997-11-25 2000-09-12 Ut Battelle, Llc Bioluminescent bioreporter integrated circuit
US6197503B1 (en) * 1997-11-26 2001-03-06 Ut-Battelle, Llc Integrated circuit biochip microsystem containing lens
US6248542B1 (en) * 1997-12-09 2001-06-19 Massachusetts Institute Of Technology Optoelectronic sensor
US20030039967A1 (en) * 1997-12-19 2003-02-27 Kris Richard M. High throughput assay system using mass spectrometry
US20030096232A1 (en) * 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
US20100105572A1 (en) * 1997-12-19 2010-04-29 Kris Richard M High throughput assay system
US5912181A (en) * 1997-12-23 1999-06-15 Petcavich; Robert J. Method for molecule detection utilizing digital micromirror technology
US6289229B1 (en) 1998-01-20 2001-09-11 Scimed Life Systems, Inc. Readable probe array for in vivo use
US6456942B1 (en) * 1998-01-25 2002-09-24 Combimatrix Corporation Network infrastructure for custom microarray synthesis and analysis
US6686150B1 (en) 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
CA2319170A1 (en) 1998-01-27 1999-07-29 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US6395480B1 (en) 1999-02-01 2002-05-28 Signature Bioscience, Inc. Computer program and database structure for detecting molecular binding events
US6287874B1 (en) 1998-02-02 2001-09-11 Signature Bioscience, Inc. Methods for analyzing protein binding events
US6287776B1 (en) 1998-02-02 2001-09-11 Signature Bioscience, Inc. Method for detecting and classifying nucleic acid hybridization
US20020177175A1 (en) * 1998-02-02 2002-11-28 Hefti John J. Coplanar waveguide biosensor for detecting molecular or cellular events
US6338968B1 (en) * 1998-02-02 2002-01-15 Signature Bioscience, Inc. Method and apparatus for detecting molecular binding events
US6485905B2 (en) * 1998-02-02 2002-11-26 Signature Bioscience, Inc. Bio-assay device
US7083985B2 (en) * 1998-02-02 2006-08-01 Hefti John J Coplanar waveguide biosensor for detecting molecular or cellular events
US6368795B1 (en) * 1998-02-02 2002-04-09 Signature Bioscience, Inc. Bio-assay device and test system for detecting molecular binding events
AU2583899A (en) 1998-02-04 1999-08-23 Invitrogen Corporation Microarrays and uses therefor
US20040035690A1 (en) * 1998-02-11 2004-02-26 The Regents Of The University Of Michigan Method and apparatus for chemical and biochemical reactions using photo-generated reagents
CA2319587C (en) * 1998-02-11 2004-09-21 University Of Houston Method and apparatus for chemical and biochemical reactions using photo-generated reagents
WO1999042558A1 (en) * 1998-02-20 1999-08-26 Nanogen, Inc. Advanced active devices and methods for molecular biological analysis and diagnostics
EP1055004A2 (en) * 1998-02-20 2000-11-29 Wolfbeis, Otto Samuel Device for detecting oligonucleotide and/or polynucleotide hybridization
AU774317B2 (en) * 1998-02-23 2004-06-24 Wisconsin Alumni Research Foundation Method and apparatus for synthesis of arrays of DNA probes
CA2321070C (en) * 1998-02-23 2010-04-06 Wisconsin Alumni Research Foundation Method and apparatus for synthesis of arrays of dna probes
US6060023A (en) * 1998-03-31 2000-05-09 Motorola, Inc. Molecular sensing apparatus
US6627154B1 (en) 1998-04-09 2003-09-30 Cyrano Sciences Inc. Electronic techniques for analyte detection
WO1999053300A1 (en) * 1998-04-14 1999-10-21 California Institute Of Technology Method and system for determining analyte activity
US6844197B1 (en) * 1998-04-17 2005-01-18 California Institute Of Technology Method for validating that the detection ability of a sensor array mimics a human nose detection ability
GB9808836D0 (en) * 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
HUP0102123A2 (en) * 1998-05-04 2001-10-28 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method and device for isolating nucleic acids
US20030203394A1 (en) * 1998-05-04 2003-10-30 Yoav Eichen Detection of a target in a sample
IL124322A (en) * 1998-05-04 2002-05-23 Technion Res & Dev Foundation Detection of an entity in a sample
CA2327525A1 (en) * 1998-05-06 1999-11-11 Cynthia Bamdad Electronic detection of nucleic acids using monolayers
DE69939464D1 (en) 1998-05-06 2008-10-16 Clinical Micro Sensors Inc ELECTRONIC METHODS FOR DETECTING ANALYTES BY USING SIMPLE LAYERS
GB9809943D0 (en) * 1998-05-08 1998-07-08 Amersham Pharm Biotech Ab Microfluidic device
US20040202579A1 (en) * 1998-05-08 2004-10-14 Anders Larsson Microfluidic device
GB9810568D0 (en) 1998-05-18 1998-07-15 Imco 1097 Limited Electrode system
US6271957B1 (en) 1998-05-29 2001-08-07 Affymetrix, Inc. Methods involving direct write optical lithography
US6270730B1 (en) * 1998-06-16 2001-08-07 Northwest Engineering Inc. Multi-well rotary synthesizer
US6251595B1 (en) 1998-06-18 2001-06-26 Agilent Technologies, Inc. Methods and devices for carrying out chemical reactions
US6375901B1 (en) 1998-06-29 2002-04-23 Agilent Technologies, Inc. Chemico-mechanical microvalve and devices comprising the same
US6256882B1 (en) 1998-07-14 2001-07-10 Cascade Microtech, Inc. Membrane probing system
FR2781886B1 (en) * 1998-07-31 2001-02-16 Commissariat Energie Atomique MULTIPLE POINT CHEMICAL OR BIOLOGICAL ANALYSIS MICROSYSTEM
US6271042B1 (en) 1998-08-26 2001-08-07 Alpha Innotech Corporation Biochip detection system
ATE535814T1 (en) * 1998-08-28 2011-12-15 Febit Holding Gmbh CARRIER FOR ANALYTE DETERMINATION METHODS AND METHOD FOR PRODUCING THE SUPPORT
FR2783179B1 (en) * 1998-09-16 2000-10-06 Commissariat Energie Atomique CHEMICAL OR BIOLOGICAL ANALYSIS DEVICE COMPRISING A PLURALITY OF ANALYSIS SITES ON A MEDIUM, AND ITS MANUFACTURING METHOD
US6740518B1 (en) 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
US6572830B1 (en) 1998-10-09 2003-06-03 Motorola, Inc. Integrated multilayered microfludic devices and methods for making the same
FR2784466B1 (en) * 1998-10-13 2002-10-18 Commissariat Energie Atomique MULTIPLE POINT CHEMICAL OR BIOLOGICAL ANALYSIS MICROSYSTEM USING A COUPLING BETWEEN THE PROBES AND A SUBSTRATE
US7071324B2 (en) * 1998-10-13 2006-07-04 Brown University Research Foundation Systems and methods for sequencing by hybridization
US6489096B1 (en) * 1998-10-15 2002-12-03 Princeton University Quantitative analysis of hybridization patterns and intensities in oligonucleotide arrays
US6096172A (en) * 1998-10-19 2000-08-01 Motorola, Inc. Method of bonding bio-molecules to a test site
IL126776A (en) * 1998-10-27 2001-04-30 Technion Res & Dev Foundation Method for gold depositions
US6545264B1 (en) 1998-10-30 2003-04-08 Affymetrix, Inc. Systems and methods for high performance scanning
EP1003032A1 (en) * 1998-11-17 2000-05-24 Interuniversitair Micro-Elektronica Centrum Vzw Sensor comprising an oligomer binding layer and method of making such sensor and arrays of such sensors
EP1003033A1 (en) * 1998-11-17 2000-05-24 Interuniversitair Micro-Elektronica Centrum Vzw Sensor comprising an oligomer binding layer and method of making such sensor and arrays of such sensors
US7135283B1 (en) 1998-11-17 2006-11-14 Nanogen, Inc. Topoisomerase type II gene polymorphisms and their use in identifying drug resistance and pathogenic strains of microorganisms
AU1742300A (en) * 1998-12-02 2000-06-19 Nanogen, Inc. Apparatus and methods for transport of charged biological materials
US6438497B1 (en) 1998-12-11 2002-08-20 Symyx Technologies Method for conducting sensor array-based rapid materials characterization
US6477479B1 (en) 1998-12-11 2002-11-05 Symyx Technologies Sensor array for rapid materials characterization
JP2002532717A (en) * 1998-12-11 2002-10-02 サイミックス テクノロジーズ、インク Sensor array based system and method for rapid material characterization
FR2787582B1 (en) * 1998-12-16 2001-01-12 Commissariat Energie Atomique METHOD FOR MANUFACTURING A BIOCHIP AND A BIOCHIP
FR2787581A1 (en) * 1998-12-16 2000-06-23 Commissariat Energie Atomique Providing modified sites for bonding oligonucleotides to biochips for use e.g. in analysis of genes, by oxidative polymerization of host and functionalized monomers at the sites
US6217744B1 (en) 1998-12-18 2001-04-17 Peter Crosby Devices for testing fluid
US20030032029A1 (en) * 1998-12-21 2003-02-13 Nanogen, Inc. Three dimensional apparatus and method for integrating sample preparation and multiplex assays
US6415188B1 (en) * 1998-12-23 2002-07-02 Dennis Sunga Fernandez Method and apparatus for multi-sensor processing
US6833267B1 (en) 1998-12-30 2004-12-21 Clinical Micro Sensors, Inc. Tissue collection devices containing biosensors
EP1151139A2 (en) 1999-01-25 2001-11-07 UT-Battelle, LLC Multifunctional and multispectral biosensor devices and methods of use
JP2002541433A (en) * 1999-02-10 2002-12-03 マクロジェン・インコーポレーテッド Method and apparatus for manufacturing chemical substance library using optical modulator
US6251685B1 (en) 1999-02-18 2001-06-26 Agilent Technologies, Inc. Readout method for molecular biological electronically addressable arrays
DE19907164C2 (en) * 1999-02-19 2002-10-24 Micronas Gmbh Measuring device and method for its production
WO2000048736A1 (en) * 1999-02-19 2000-08-24 GeSIM Gesellschaft für Silizium-Mikrosysteme mbH Sensor-measuring field for controlling functioning of a micropipette
ATE508200T1 (en) * 1999-02-23 2011-05-15 Caliper Life Sciences Inc SEQUENCING THROUGH INCORPORATION
US6558945B1 (en) * 1999-03-08 2003-05-06 Aclara Biosciences, Inc. Method and device for rapid color detection
WO2000053625A2 (en) * 1999-03-11 2000-09-14 Combimatrix Corporation Microarrays of peptide affinity probes for analyzing gene products and methods for analyzing gene products
TW496775B (en) * 1999-03-15 2002-08-01 Aviva Bioscience Corp Individually addressable micro-electromagnetic unit array chips
CN1185492C (en) 1999-03-15 2005-01-19 清华大学 Single-point strobed micro electromagnetic units array chip or electromagnetic biologic chip and application thereof
US6403317B1 (en) * 1999-03-26 2002-06-11 Affymetrix, Inc. Electronic detection of hybridization on nucleic acid arrays
AU4058500A (en) * 1999-03-30 2000-10-16 Nanogen, Inc. Single nucleotide polymorphic discrimination by electronic dot blot assay on semiconductor microchips
US6399303B1 (en) 1999-04-07 2002-06-04 Integrated Nano-Technologies, Llc High resolution DNA detection methods and devices
US6238868B1 (en) * 1999-04-12 2001-05-29 Nanogen/Becton Dickinson Partnership Multiplex amplification and separation of nucleic acid sequences using ligation-dependant strand displacement amplification and bioelectronic chip technology
US6531302B1 (en) * 1999-04-12 2003-03-11 Nanogen/Becton Dickinson Partnership Anchored strand displacement amplification on an electronically addressable microchip
WO2000062036A1 (en) * 1999-04-12 2000-10-19 Nanogen/Becton Dickinson Partnership Amplification and separation of nucleic acid sequences using strand displacement amplification and bioelectronic microchip technology
US6326173B1 (en) * 1999-04-12 2001-12-04 Nanogen/Becton Dickinson Partnership Electronically mediated nucleic acid amplification in NASBA
DE19916867A1 (en) 1999-04-14 2000-10-19 Fraunhofer Ges Forschung Making a molecular array on which molecules are immobilized, using micro-compartments or microcapillary reactors on planar substrates with sensor elements employs microelectronic production techniques
DE19916921A1 (en) * 1999-04-14 2000-10-19 Fraunhofer Ges Forschung Electrical sensor array
US7312087B2 (en) * 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US20040053290A1 (en) * 2000-01-11 2004-03-18 Terbrueggen Robert Henry Devices and methods for biochip multiplexing
US20020177135A1 (en) 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US6518056B2 (en) * 1999-04-27 2003-02-11 Agilent Technologies Inc. Apparatus, systems and method for assaying biological materials using an annular format
US6238909B1 (en) * 1999-05-04 2001-05-29 Motorola, Inc. Method and apparatus for obtaining electric field-enhanced bioconjugation
IL129835A (en) 1999-05-06 2008-03-20 Ofer Markman Polysaccharide sequencing and structure determination
US7056678B1 (en) 2000-05-04 2006-06-06 Procognia Ltd Polysaccharide structure and sequence determination
US6631333B1 (en) 1999-05-10 2003-10-07 California Institute Of Technology Methods for remote characterization of an odor
US7122152B2 (en) * 1999-05-10 2006-10-17 University Of Florida Spatiotemporal and geometric optimization of sensor arrays for detecting analytes fluids
ATE319080T1 (en) * 1999-05-10 2006-03-15 California Inst Of Techn USE OF A SPATIO-TEMPORAL RESPONSE IN SENSOR ARRAYS FOR THE DETECTION OF ANALYTES IN FLUID
US6592821B1 (en) * 1999-05-17 2003-07-15 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
DE60045350D1 (en) 1999-06-01 2011-01-20 Baylor College Medicine COMPOSITIONS AND METHODS FOR THE THERAPEUTIC APPLICATION OF A SEQUENCE ASSOCIATED WITH THE GEN ATONAL
AU6402900A (en) * 1999-06-08 2000-12-28 Biomicro Systems, Inc. Laser ablation of doped fluorocarbon materials and applications thereof
WO2000079217A2 (en) * 1999-06-17 2000-12-28 The Penn State Research Foundation Micro-electro-mechanical gyroscope
US6572825B1 (en) * 1999-10-04 2003-06-03 Sandia Corporation Apparatus for thermally evolving chemical analytes from a removable substrate
AU784040B2 (en) * 1999-06-25 2006-01-19 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6346423B1 (en) 1999-07-16 2002-02-12 Agilent Technologies, Inc. Methods and compositions for producing biopolymeric arrays
US6589779B1 (en) 1999-07-16 2003-07-08 Board Of Regents, The University Of Texas System General signaling protocol for chemical receptors in immobilized matrices
ATE417127T1 (en) 1999-07-26 2008-12-15 Clinical Micro Sensors Inc NUKELIC ACID SEQUENCE DETERMINATION USING ELECTRONIC DETECTION
DE19935433A1 (en) * 1999-08-01 2001-03-01 Febit Ferrarius Biotech Gmbh Microfluidic reaction carrier
US20040185462A1 (en) * 1999-08-06 2004-09-23 Tum Gene, Inc. Method of and detecting apparatus and detecting chip for single base substitution SNP and point mutation of genes
AU6751800A (en) * 1999-08-13 2001-03-13 Aventis Research And Technologies Gmbh Microelectronic molecular descriptor array devices, methods, procedures, and formats for combinatorial selection of intermolecular ligand binding structures and for drug screening
US6411110B1 (en) * 1999-08-17 2002-06-25 Micron Technology, Inc. Apparatuses and methods for determining if protective coatings on semiconductor substrate holding devices have been compromised
US6890715B1 (en) * 1999-08-18 2005-05-10 The California Institute Of Technology Sensors of conducting and insulating composites
US6381025B1 (en) 1999-08-19 2002-04-30 Texas Tech University Interferometric detection system and method
WO2001014823A1 (en) 1999-08-19 2001-03-01 The Regents Of The University Of California Apparatus and method for visually identifying micro-forces with a palette of cantilever array blocks
US6906797B1 (en) * 1999-09-13 2005-06-14 Aclara Biosciences, Inc. Side light activated microfluid channels
EP1221050A2 (en) 1999-09-30 2002-07-10 Nanogen, Inc. Biomolecular attachment sites on microelectronic arrays
EP1146331B1 (en) * 1999-10-20 2008-09-10 Shigeori Takenaka Gene detecting chip, detector, and detecting method
US7364920B2 (en) * 1999-10-27 2008-04-29 Technion Research And Development Foundation Ltd. Method for gold deposition
US6361958B1 (en) * 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
US6596483B1 (en) * 1999-11-12 2003-07-22 Motorola, Inc. System and method for detecting molecules using an active pixel sensor
US6875619B2 (en) * 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
US6451191B1 (en) 1999-11-18 2002-09-17 3M Innovative Properties Company Film based addressable programmable electronic matrix articles and methods of manufacturing and using the same
US6303082B1 (en) * 1999-12-15 2001-10-16 Nanogen, Inc. Permeation layer attachment chemistry and method
US20030091477A1 (en) * 1999-12-22 2003-05-15 Paul Eric A. Flow-thru chip cartridge, chip holder, system & method thereof
DE10000629C5 (en) * 2000-01-10 2010-06-02 november Aktiengesellschaft, Gesellschaft für Molekulare Medizin Method of identifying a label applied to a solid
US6635423B2 (en) 2000-01-14 2003-10-21 Integriderm, Inc. Informative nucleic acid arrays and methods for making same
US6325977B1 (en) 2000-01-18 2001-12-04 Agilent Technologies, Inc. Optical detection system for the detection of organic molecules
DE10002595A1 (en) * 2000-01-21 2001-08-09 Infineon Technologies Ag Measuring method and sensor device for chemical and pharmaceutical analysis and synthesis
DE10002597A1 (en) * 2000-01-21 2001-08-02 Infineon Technologies Ag Method and device for identifying molecules present in a carrier liquid
DE60135092D1 (en) * 2000-01-31 2008-09-11 Univ Texas PORTABLE DEVICE WITH A SENSOR ARRAY ARRANGEMENT
US6824669B1 (en) 2000-02-17 2004-11-30 Motorola, Inc. Protein and peptide sensors using electrical detection methods
DE10015818A1 (en) 2000-03-30 2001-10-18 Infineon Technologies Ag Biosensor and method for determining macromolecular biopolymers using a biosensor
JP2003529772A (en) * 2000-03-30 2003-10-07 インフィネオン テクノロジーズ アクチエンゲゼルシャフト Biosensor, biosensor array, method for producing biosensor electrode, method for producing biosensor
DE10015547C2 (en) * 2000-03-30 2002-02-14 Aventis Res & Tech Gmbh & Co Method for the detection of molecules by means of impedance spectroscopy and device for carrying out these methods
DE10015821A1 (en) * 2000-03-30 2001-10-18 Infineon Technologies Ag New sensor, useful for detecting biopolymers, particularly protein or nucleic acid, comprises measuring changes in optical signal from trench coated with immobilized capture molecules
WO2001081896A1 (en) * 2000-04-24 2001-11-01 Eagle Research & Development, Llc An ultra-fast nucleic acid sequencing device and a method for making and using the same
US6413792B1 (en) 2000-04-24 2002-07-02 Eagle Research Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
US8232582B2 (en) 2000-04-24 2012-07-31 Life Technologies Corporation Ultra-fast nucleic acid sequencing device and a method for making and using the same
US7001792B2 (en) * 2000-04-24 2006-02-21 Eagle Research & Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
AU5252001A (en) * 2000-05-02 2001-11-12 Lumitest Ltd. Method of obtaining medical information from thermochemiluminescence of biological fluids and suspensions of tissues
US7132251B1 (en) * 2000-05-04 2006-11-07 Procognia Ltd Method and composition for analyzing a carbohydrate polymer
US8399383B2 (en) * 2000-05-04 2013-03-19 Yale University Protein chips for high throughput screening of protein activity
US6291882B1 (en) * 2000-06-02 2001-09-18 Siliconware Precision Industries Co., Letd. Packaging process and structure of electronic device
US7351376B1 (en) * 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
US6602400B1 (en) 2000-06-15 2003-08-05 Motorola, Inc. Method for enhanced bio-conjugation events
EP1311839B1 (en) 2000-06-21 2006-03-01 Bioarray Solutions Ltd Multianalyte molecular analysis using application-specific random particle arrays
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US20030118486A1 (en) * 2000-07-03 2003-06-26 Xeotron Corporation Fluidic methods and devices for parallel chemical reactions
AU2001273156A1 (en) * 2000-07-03 2002-01-14 Xeotron Corporation Devices and methods for carrying out chemical reactions using photogenerated reagents
DE10036457A1 (en) * 2000-07-26 2002-02-14 Giesing Michael Use of an imaging photoelectric area sensor for evaluating biochips and imaging processes therefor
US7189358B2 (en) * 2000-08-08 2007-03-13 California Institute Of Technology Integrated micropump analysis chip and method of making the same
US6567163B1 (en) 2000-08-17 2003-05-20 Able Signal Company Llc Microarray detector and synthesizer
US6545758B1 (en) * 2000-08-17 2003-04-08 Perry Sandstrom Microarray detector and synthesizer
US6914423B2 (en) 2000-09-05 2005-07-05 Cascade Microtech, Inc. Probe station
US6965226B2 (en) 2000-09-05 2005-11-15 Cascade Microtech, Inc. Chuck for holding a device under test
AU2001290954A1 (en) * 2000-09-15 2002-03-26 Engeneos, Inc. Devices and methods for direct electronic readout of biomolecular interactions
AU2001292884A1 (en) * 2000-09-20 2002-04-02 Molecular Reflections Microfabricated ultrasound array for use as resonant sensors
US6780584B1 (en) * 2000-09-27 2004-08-24 Nanogen, Inc. Electronic systems and component devices for macroscopic and microscopic molecular biological reactions, analyses and diagnostics
US6818109B2 (en) 2000-09-29 2004-11-16 Kabushiki Kaisha Toshiba Nucleic acid detections sensor
CN100495030C (en) * 2000-09-30 2009-06-03 清华大学 Multi-force operator and use thereof
DE10049901C2 (en) * 2000-10-10 2003-01-02 Aventis Res & Tech Gmbh & Co Apparatus and method for electrically accelerated immobilization and for detection of molecules
US6922081B2 (en) 2000-10-16 2005-07-26 Infineon Technologies Ag Electronic circuit, sensor arrangement and method for processing a sensor signal
DE10051252A1 (en) * 2000-10-16 2002-04-25 Caesar Stiftung Biochip
DE10051396A1 (en) * 2000-10-17 2002-04-18 Febit Ferrarius Biotech Gmbh An integrated synthesis and identification of an analyte, comprises particles immobilized at a carrier to be coupled to receptors in a structured pattern to give receptor arrays for biochemical reactions
US20030045005A1 (en) 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
AU2002241803A1 (en) * 2000-10-20 2002-06-18 The Board Of Trustees Of The Leland Stanford Junior University Transient electrical signal based methods and devices for characterizing molecular interaction and/or motion in a sample
US7407773B2 (en) 2000-11-03 2008-08-05 Procognia, Ltd. Method for characterizing a carbohydrate polymer
JP4176467B2 (en) * 2000-11-03 2008-11-05 プロコグニア （イスラエル） リミテッド Methods for comparative analysis of carbohydrate polymers
US6586946B2 (en) 2000-11-13 2003-07-01 Signature Bioscience, Inc. System and method for detecting and identifying molecular events in a test sample using a resonant test structure
WO2002061858A2 (en) 2000-11-17 2002-08-08 Thermogenic Imaging, Inc. Apparatus and methods for infrared calorimetric measurements
US20020132360A1 (en) 2000-11-17 2002-09-19 Flir Systems Boston, Inc. Apparatus and methods for infrared calorimetric measurements
SE0004334D0 (en) * 2000-11-24 2000-11-24 Sahltech Ab Electron spectroscopy
DE10143173A1 (en) 2000-12-04 2002-06-06 Cascade Microtech Inc Wafer probe has contact finger array with impedance matching network suitable for wide band
US6777244B2 (en) * 2000-12-06 2004-08-17 Hrl Laboratories, Llc Compact sensor using microcavity structures
US6835552B2 (en) * 2000-12-14 2004-12-28 The Regents Of The University Of California Impedance measurements for detecting pathogens attached to antibodies
JP4534352B2 (en) * 2000-12-27 2010-09-01 株式会社ニコン Organic molecule detecting semiconductor element, organic molecule detecting semiconductor device, and organic molecule measuring method using the same
US6887667B2 (en) * 2000-12-28 2005-05-03 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California Method and apparatus to identify small variations of biomolecules
US6783992B2 (en) 2001-01-03 2004-08-31 Agilent Technologies, Inc. Methods and using chemico-mechanical microvalve devices for the selective separation of components from multi-component fluid samples
US20020127855A1 (en) * 2001-01-04 2002-09-12 Sauer Jon Robert Method for fabricating a pattern in a mask on a surface of an object and product manufactured thereby
US20040099310A1 (en) * 2001-01-05 2004-05-27 Per Andersson Microfluidic device
WO2002054052A1 (en) * 2001-01-08 2002-07-11 Leonard Fish Diagnostic instruments and methods for detecting analytes
CN1302285C (en) * 2001-01-12 2007-02-28 东丽株式会社 Selectively hybridizable substance immobilization fiber, fiber array comprising bundle of such fibers, selective hybridizing method, device therefor and base
US6809828B2 (en) 2001-01-25 2004-10-26 Texas Tech University Universal detector for biological and chemical separations or assays using plastic microfluidic devices
DE10103954B4 (en) * 2001-01-30 2005-10-06 Advalytix Ag Method for analyzing macromolecules
WO2002060575A2 (en) * 2001-02-01 2002-08-08 Signature Bioscience, Inc. Well-based biosensor for detecting molecular or cellular events
ATE345497T1 (en) * 2001-02-07 2006-12-15 Massachusetts Inst Technology OPTOELECTRONIC DETECTION SYSTEM
US8216797B2 (en) * 2001-02-07 2012-07-10 Massachusetts Institute Of Technology Pathogen detection biosensor
US7422860B2 (en) 2001-02-07 2008-09-09 Massachusetts Institute Of Technology Optoelectronic detection system
WO2002065127A2 (en) * 2001-02-12 2002-08-22 Signature Bioscience, Inc. A system and method for characterizing the permittivity of molecular events
WO2002066969A1 (en) * 2001-02-19 2002-08-29 Kyowa Medex Co., Ltd. Charged component detector, its using method and detection panel
US20020165675A1 (en) * 2001-03-03 2002-11-07 Golovlev Valeri V. Method and microelectronic device for multi-site molecule detection
DE10112778A1 (en) * 2001-03-16 2002-10-02 Infineon Technologies Ag Biosensor, device and method for detecting nucleic acids by means of at least two units for immobilizing nucleic acids
CA2441206A1 (en) 2001-03-19 2002-09-26 Gyros Ab Characterization of reaction variables
US7027932B2 (en) 2001-03-21 2006-04-11 Olympus Optical Co., Ltd. Biochemical examination method
US6706163B2 (en) * 2001-03-21 2004-03-16 Michael Seul On-chip analysis of particles and fractionation of particle mixtures using light-controlled electrokinetic assembly of particles near surfaces
US20050196746A1 (en) * 2001-03-24 2005-09-08 Jia Xu High-density ion transport measurement biochip devices and methods
US20060029955A1 (en) * 2001-03-24 2006-02-09 Antonio Guia High-density ion transport measurement biochip devices and methods
US20050009004A1 (en) * 2002-05-04 2005-01-13 Jia Xu Apparatus including ion transport detecting structures and methods of use
US20050058990A1 (en) * 2001-03-24 2005-03-17 Antonio Guia Biochip devices for ion transport measurement, methods of manufacture, and methods of use
AU2002307218A1 (en) * 2001-03-24 2002-10-08 Aviva Biosciences Corporation Biochips including ion transport detecting structures and methods of use
US20040146849A1 (en) * 2002-01-24 2004-07-29 Mingxian Huang Biochips including ion transport detecting structures and methods of use
US6960437B2 (en) 2001-04-06 2005-11-01 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
US6627461B2 (en) 2001-04-18 2003-09-30 Signature Bioscience, Inc. Method and apparatus for detection of molecular events using temperature control of detection environment
US20020160427A1 (en) * 2001-04-27 2002-10-31 Febit Ag Methods and apparatuses for electronic determination of analytes
EP1392342B1 (en) * 2001-05-11 2015-09-23 Yale University Global analysis of protein activities using proteome chips
US20050009101A1 (en) * 2001-05-17 2005-01-13 Motorola, Inc. Microfluidic devices comprising biochannels
US6563117B2 (en) * 2001-06-02 2003-05-13 Ilya Feygin Article comprising IR-reflective multi-well plates
US6570158B2 (en) * 2001-06-02 2003-05-27 Hya Feygin Method and apparatus for infrared-spectrum imaging
US7302830B2 (en) 2001-06-06 2007-12-04 Symyx Technologies, Inc. Flow detectors having mechanical oscillators, and use thereof in flow characterization systems
US20040048241A1 (en) * 2001-06-11 2004-03-11 Freeman Beverly Annette Methods for attaching molecules
US20040248282A1 (en) * 2001-06-11 2004-12-09 Pisharody Sobha M. Electronic detection of biological molecules using thin layers
US20040023253A1 (en) * 2001-06-11 2004-02-05 Sandeep Kunwar Device structure for closely spaced electrodes
US6824974B2 (en) * 2001-06-11 2004-11-30 Genorx, Inc. Electronic detection of biological molecules using thin layers
US6461808B1 (en) 2001-06-12 2002-10-08 Signature Bioscience, Inc. Pipette-loaded bioassay assembly for detecting molecular or cellular events
JP2002372533A (en) * 2001-06-13 2002-12-26 Kiwamu Akagi Examination method of blood, examination chip, and examination device
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
AU2002329186A1 (en) * 2001-06-21 2003-01-08 Virginia Tech Intellectual Properties, Inc. Electro-optical detection device
US6649402B2 (en) 2001-06-22 2003-11-18 Wisconsin Alumni Research Foundation Microfabricated microbial growth assay method and apparatus
US20040166593A1 (en) * 2001-06-22 2004-08-26 Nolte David D. Adaptive interferometric multi-analyte high-speed biosensor
US6685885B2 (en) 2001-06-22 2004-02-03 Purdue Research Foundation Bio-optical compact dist system
DE10133363A1 (en) * 2001-07-10 2003-01-30 Infineon Technologies Ag Measuring cell and measuring field with such measuring cells as well as using a measuring cell and using a measuring field
US6653653B2 (en) 2001-07-13 2003-11-25 Quantum Logic Devices, Inc. Single-electron transistors and fabrication methods in which a projecting feature defines spacing between electrodes
US20030013208A1 (en) * 2001-07-13 2003-01-16 Milagen, Inc. Information enhanced antibody arrays
US6483125B1 (en) 2001-07-13 2002-11-19 North Carolina State University Single electron transistors in which the thickness of an insulating layer defines spacing between electrodes
US6893822B2 (en) 2001-07-19 2005-05-17 Nanogen Recognomics Gmbh Enzymatic modification of a nucleic acid-synthetic binding unit conjugate
DE10136008B4 (en) * 2001-07-24 2005-03-31 Advalytix Ag Method for analyzing macromolecules and method for producing an analysis device
US20030022150A1 (en) * 2001-07-24 2003-01-30 Sampson Jeffrey R. Methods for detecting a target molecule
WO2003011553A1 (en) * 2001-07-31 2003-02-13 Massachusetts Institute Of Technology On-chip membrane maker
DE60216115T2 (en) * 2001-08-01 2007-05-31 Merck & Co., Inc. BENZIMIDAZO 4,5-föISOCHINOLINONE DERIVATIVES
US20030032000A1 (en) * 2001-08-13 2003-02-13 Signature Bioscience Inc. Method for analyzing cellular events
US20060073530A1 (en) * 2001-08-15 2006-04-06 Olaf Schneewind Methods and compositions involving sortase B
AU2002327490A1 (en) 2001-08-21 2003-06-30 Cascade Microtech, Inc. Membrane probing system
US10539561B1 (en) 2001-08-30 2020-01-21 Customarray, Inc. Enzyme-amplified redox microarray detection process
EP2311934B1 (en) * 2001-09-06 2013-06-05 Rapid Micro Biosystems, Inc. Rapid detection of replicating cells
US20030068655A1 (en) * 2001-09-12 2003-04-10 Protiveris, Inc. Microcantilever apparatus and methods for detection of enzymes
DE10145701A1 (en) * 2001-09-17 2003-04-10 Infineon Technologies Ag Fluorescence biosensor chip and fluorescence biosensor chip arrangement
US7439346B2 (en) 2001-10-12 2008-10-21 Perkinelmer Las Inc. Nucleic acids arrays and methods of use therefor
CA2463725A1 (en) 2001-10-12 2003-11-06 Spectral Genomics, Inc. Compilations of nucleic acids and arrays and methods of using them
WO2003031958A2 (en) * 2001-10-12 2003-04-17 Wisconsin Alumni Research Foundation Microwave dielectric spectroscopy method and apparatus for assays of proteins and other biological molecules
US20040002073A1 (en) 2001-10-15 2004-01-01 Li Alice Xiang Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection
EP1436426A4 (en) * 2001-10-24 2005-11-02 Singulex Inc Methods for detecting genetic haplotypes by interaction with probes
US20040023236A1 (en) * 2001-10-26 2004-02-05 Potter Michael D. Chemical and biological hazard sensor system and methods thereof
US20060121502A1 (en) * 2001-11-09 2006-06-08 Robert Cain Microfluidics apparatus for cantilevers and methods of use therefor
US6926864B2 (en) * 2001-11-09 2005-08-09 Protiveris Inc Microfluidics apparatus and methods for use thereof
AU2002359435A1 (en) * 2001-11-21 2003-06-10 Integrated Nano-Technologies, Llc Fabrication of a high resolution biological molecule detection device with aluminum electrical conductors
WO2003048355A1 (en) * 2001-11-30 2003-06-12 Wisconsin Alumni Research Foundation Method and apparatus for high frequency interfacing to biochemical membranes
US6960298B2 (en) * 2001-12-10 2005-11-01 Nanogen, Inc. Mesoporous permeation layers for use on active electronic matrix devices
FR2835058B1 (en) * 2002-01-21 2004-03-12 Centre Nat Rech Scient METHOD FOR DETECTING AT LEAST ONE CHARACTERISTIC PARAMETER OF PROBE MOLECULES FIXED ON AT LEAST ONE ACTIVE ZONE OF A SENSOR
US20030178641A1 (en) * 2002-01-23 2003-09-25 Blair Steven M. Microfluidic platforms for use with specific binding assays, specific binding assays that employ microfluidics, and methods
US7524459B2 (en) * 2002-01-24 2009-04-28 California Institute Of Technology In Pasadena Optoelectronic and microfluidic integration for miniaturized spectroscopic devices
EP2128248B2 (en) 2002-02-01 2017-01-11 Life Technologies Corporation Oligonucleotide compositions with enhanced efficiency
US20030166282A1 (en) 2002-02-01 2003-09-04 David Brown High potency siRNAS for reducing the expression of target genes
JP3786881B2 (en) * 2002-02-01 2006-06-14 富士写真フイルム株式会社 Receptor-ligand association reaction method
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
US6887362B2 (en) * 2002-02-06 2005-05-03 Nanogen, Inc. Dielectrophoretic separation and immunoassay methods on active electronic matrix devices
GB2385132A (en) * 2002-02-12 2003-08-13 Seiko Epson Corp A capacitance sensor
US20030154149A1 (en) * 2002-02-13 2003-08-14 Dilip Gajendragadkar System and method of creating and executing a restricted stock sale plan
US20050266455A1 (en) * 2002-03-02 2005-12-01 Sci Tec, Inc. Method and microelectronic device for multi-site molecule detection
US20030203384A1 (en) * 2002-03-08 2003-10-30 Chafin David R. Multiplex detection of biological materials in a sample
US6916621B2 (en) 2002-03-27 2005-07-12 Spectral Genomics, Inc. Methods for array-based comparitive binding assays
JP2005521425A (en) 2002-04-01 2005-07-21 フルイディグム コーポレイション Microfluidic particle analysis system
US20040110277A1 (en) * 2002-04-12 2004-06-10 Seiko Epson Corporation Sensor cell, bio-sensor, capacitance element manufacturing method, biological reaction detection method and genetic analytical method
AU2003228711C1 (en) 2002-04-26 2010-01-07 Board Of Regents, The University Of Texas System Method and system for the detection of cardiac risk factors
WO2003093494A2 (en) * 2002-05-04 2003-11-13 Aviva Biosciences Corporation Apparatus including ion transport detecting structures and methods of use
EP1511862A4 (en) * 2002-05-14 2006-01-18 Nanosphere Inc Electrical detection of dna hybridization and specific binding events
US6841379B2 (en) 2002-05-15 2005-01-11 Beckman Coulter, Inc. Conductive microplate
US20040072208A1 (en) * 2002-05-23 2004-04-15 Peter Warthoe Surface acoustic wave sensors and method for detecting target analytes
DE10224567B4 (en) 2002-06-03 2014-10-23 Boehringer Ingelheim Vetmedica Gmbh Sensor arrangement and method for operating a sensor arrangement
US6952651B2 (en) * 2002-06-17 2005-10-04 Intel Corporation Methods and apparatus for nucleic acid sequencing by signal stretching and data integration
JP4101801B2 (en) 2002-06-24 2008-06-18 シーメンス アクチエンゲゼルシャフト Biosensor array and method of use thereof
US6673717B1 (en) 2002-06-26 2004-01-06 Quantum Logic Devices, Inc. Methods for fabricating nanopores for single-electron devices
US20040005572A1 (en) * 2002-07-05 2004-01-08 Rosner S. Jeffrey Electronically readable microarrays
WO2004009840A1 (en) * 2002-07-24 2004-01-29 Board Of Regents, The University Of Texas System Capture and detection of microbes by membrane methods
US7601493B2 (en) * 2002-07-26 2009-10-13 Nanogen, Inc. Methods and apparatus for screening and detecting multiple genetic mutations
US20060099224A1 (en) 2002-08-12 2006-05-11 David Kirn Methods and compositions concerning poxviruses and cancer
US7267751B2 (en) 2002-08-20 2007-09-11 Nanogen, Inc. Programmable multiplexed active biologic array
US7563600B2 (en) 2002-09-12 2009-07-21 Combimatrix Corporation Microarray synthesis and assembly of gene-length polynucleotides
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
US7143785B2 (en) 2002-09-25 2006-12-05 California Institute Of Technology Microfluidic large scale integration
ATE531257T1 (en) 2002-09-27 2011-11-15 Gen Hospital Corp MICROFLUIDIC DEVICE FOR CELL SEPARATION AND USES THEREOF
EP1546412B1 (en) 2002-10-02 2014-05-21 California Institute Of Technology Microfluidic nucleic acid analysis
WO2004036207A2 (en) 2002-10-18 2004-04-29 Symyx Technologies, Inc. Environmental control system fluid sensing system and method comprising a sesnsor with a mechanical resonator
KR100479263B1 (en) * 2002-10-18 2005-03-28 한국전자통신연구원 Fluorescence detecting device for detecting biomolecule using amorphous-silicon thin film transistor
US7043969B2 (en) 2002-10-18 2006-05-16 Symyx Technologies, Inc. Machine fluid sensor and method
US20040209352A1 (en) * 2002-10-28 2004-10-21 Nobuhiko Ozaki Integrated electrode and cell immobilization device equipped with the integrated electrode
US7364896B2 (en) 2002-10-31 2008-04-29 Agilent Technologies, Inc. Test strips including flexible array substrates and method of hybridization
US20040087009A1 (en) * 2002-10-31 2004-05-06 Schembri Carol T. Array substrates having protective layer
US7390457B2 (en) 2002-10-31 2008-06-24 Agilent Technologies, Inc. Integrated microfluidic array device
AU2003266711A1 (en) * 2002-11-14 2004-06-03 Cosel Co., Ltd. Method of detecting hybridization
AU2003295591A1 (en) * 2002-11-15 2004-06-15 The Regents Of The University Of California System and method for multiplexed biomolecular analysis
US7526114B2 (en) 2002-11-15 2009-04-28 Bioarray Solutions Ltd. Analysis, secure access to, and transmission of array images
US7344678B2 (en) * 2002-11-15 2008-03-18 The Regents Of The University Of California Composite sensor membrane
US8591817B1 (en) * 2002-11-21 2013-11-26 Genefluidics, Inc. Elevated temperature assay system
US7163659B2 (en) * 2002-12-03 2007-01-16 Hewlett-Packard Development Company, L.P. Free-standing nanowire sensor and method for detecting an analyte in a fluid
US7095010B2 (en) * 2002-12-04 2006-08-22 California Institute Of Technology Silicon on insulator resonator sensors and modulators and method of operating the same
JP4832759B2 (en) * 2002-12-11 2011-12-07 サントル ナショナル ドゥ ラ ルシェルシュ シアンティフィク Method for electronically detecting at least one specific interaction between a probe molecule and a target biomolecule
US20040115654A1 (en) * 2002-12-16 2004-06-17 Intel Corporation Laser exposure of photosensitive masks for DNA microarray fabrication
DE10259820B4 (en) 2002-12-19 2006-05-24 Siemens Ag DNA chip
JP4399211B2 (en) 2002-12-21 2010-01-13 株式会社ハイニックスセミコンダクター Biosensor
AU2003290429A1 (en) * 2002-12-25 2004-07-22 Casio Computer Co., Ltd. Optical dna sensor, dna reading apparatus, identification method of dna and manufacturing method of optical dna sensor
US7214528B1 (en) 2002-12-31 2007-05-08 Oregon Health & Sciences University Device for direct electrical detection of molecules and molecule-molecule interactions
JP3920223B2 (en) * 2003-01-07 2007-05-30 日本碍子株式会社 Reactive chip and target substance binding detection method using this chip
WO2005016115A2 (en) * 2003-01-23 2005-02-24 Montana State University Biosensors utilizing dendrimer-immobilized ligands and their use thereof
CN1514243A (en) * 2003-04-30 2004-07-21 成都夸常科技有限公司 Method of preceeding qualitative and lor quantitative analysis against target substance its device and marker and detecting reagent box
US7721590B2 (en) 2003-03-21 2010-05-25 MEAS France Resonator sensor assembly
EP1644717A2 (en) 2003-03-21 2006-04-12 Symyx Technologies, Inc. Mechanical resonator
US20050064452A1 (en) * 2003-04-25 2005-03-24 Schmid Matthew J. System and method for the detection of analytes
US9317922B2 (en) 2003-05-16 2016-04-19 Board Of Regents The University Of Texas System Image and part recognition technology
US7651850B2 (en) 2003-05-16 2010-01-26 Board Of Regents, The University Of Texas System Image and part recognition technology
US7492172B2 (en) 2003-05-23 2009-02-17 Cascade Microtech, Inc. Chuck for holding a device under test
US7057404B2 (en) 2003-05-23 2006-06-06 Sharp Laboratories Of America, Inc. Shielded probe for testing a device under test
US20040248323A1 (en) 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
US20040248306A1 (en) * 2003-06-09 2004-12-09 Hernandez Juan J. Microfluidic water analytical device
CA2694876A1 (en) 2003-07-01 2005-03-24 Eric R. Diebold Electrochemical affinity biosensor system and methods
US20090088982A1 (en) * 2003-07-31 2009-04-02 Fukushima Noelle H Co-detection of single polypeptide and polynucleotide molecules
US20050033133A1 (en) * 2003-08-06 2005-02-10 Clifford Kraft Implantable chip medical diagnostic device for bodily fluids
US20050037508A1 (en) * 2003-08-12 2005-02-17 Juan Hernandez Microfluidic titration apparatus
US6867062B2 (en) 2003-08-15 2005-03-15 Eastman Kodak Company Method for forming light shield process for solid-state image sensor with multi-metallization layer
KR100529233B1 (en) * 2003-09-06 2006-02-24 한국전자통신연구원 Sensor and method for manufacturing the same
US7276351B2 (en) 2003-09-10 2007-10-02 Seahorse Bioscience Method and device for measuring multiple physiological properties of cells
US7927796B2 (en) 2003-09-18 2011-04-19 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
WO2005031305A2 (en) 2003-09-22 2005-04-07 Bioarray Solutions, Ltd. Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
EP1671125A1 (en) * 2003-09-29 2006-06-21 Koninklijke Philips Electronics N.V. Label-free detection of biomolecules
US20080021674A1 (en) * 2003-09-30 2008-01-24 Robert Puskas Methods for Enhancing the Analysis of Particle Detection
FR2860641B1 (en) * 2003-10-03 2006-10-13 Commissariat Energie Atomique ADDRESSABLE RESISTOR MATRIX INDEPENDENTLY, AND METHOD FOR MAKING SAME
US8658349B2 (en) 2006-07-13 2014-02-25 Seahorse Bioscience Cell analysis apparatus and method
US20060257286A1 (en) 2003-10-17 2006-11-16 Adams Jesse D Self-sensing array of microcantilevers for chemical detection
US7250626B2 (en) 2003-10-22 2007-07-31 Cascade Microtech, Inc. Probe testing structure
US7563569B2 (en) 2003-10-28 2009-07-21 Michael Seul Optimization of gene expression analysis using immobilized capture probes
JP2007509629A (en) 2003-10-29 2007-04-19 バイオアレイ ソリューションズ リミテッド Complex nucleic acid analysis by cleavage of double-stranded DNA
JP4389088B2 (en) * 2003-11-07 2009-12-24 公立大学法人大阪府立大学 Electrical resistance type detection sensor and detection method
US7651868B2 (en) 2003-12-11 2010-01-26 The Board Of Regents Of The University Of Texas System Method and system for the analysis of saliva using a sensor array
CA2548219A1 (en) 2003-12-18 2005-06-30 Yehudit Amor Method for analyzing a glycomolecule
WO2005062049A2 (en) * 2003-12-22 2005-07-07 Interuniversitair Microelektronica Centrum (Imec) The use of microelectronic structures for patterned deposition of molecules onto surfaces
US7187188B2 (en) 2003-12-24 2007-03-06 Cascade Microtech, Inc. Chuck with integrated wafer support
US7427868B2 (en) 2003-12-24 2008-09-23 Cascade Microtech, Inc. Active wafer probe
US8581308B2 (en) 2004-02-19 2013-11-12 Rochester Institute Of Technology High temperature embedded charge devices and methods thereof
KR101059562B1 (en) 2004-02-20 2011-08-26 삼성전자주식회사 Sensitivity Bio FET
US20060257854A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Membrane assay system including preloaded particles
KR20050087955A (en) * 2004-02-27 2005-09-01 삼성전자주식회사 Biomolecule sensing method using field effect transistor with controllable debye length
US7781226B2 (en) * 2004-02-27 2010-08-24 The Board Of Regents Of The University Of Texas System Particle on membrane assay system
US20060257941A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Integration of fluids and reagents into self-contained cartridges containing particle and membrane sensor elements
US20060257991A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Integration of fluids and reagents into self-contained cartridges containing particle-based sensor elements and membrane-based sensor elements
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
SG151334A1 (en) * 2004-04-01 2009-04-30 Univ Nanyang Addressable chem/bio chip array
KR100613612B1 (en) 2004-04-27 2006-08-18 삼성전자주식회사 Apparatus and method of detecting bio bonding using circuit of inductor and capacitor
US6878919B1 (en) * 2004-04-28 2005-04-12 Eastman Kodak Company Thin lightshield process for solid-state image sensors
US20060019273A1 (en) * 2004-05-12 2006-01-26 Connolly Dennis M Detection card for analyzing a sample for a target nucleic acid molecule, and uses thereof
US20050255448A1 (en) * 2004-05-13 2005-11-17 Arun Majumdar System for amplifying optical detection of cantilever deflection
US8911942B2 (en) 2004-05-20 2014-12-16 Quest Diagnostics Investments Incorporated Single label comparative hybridization
AU2005245996A1 (en) 2004-05-21 2005-12-01 Atonomics A/S Surface acoustic wave sensor comprising a hydrogel
JP4759707B2 (en) * 2004-05-28 2011-08-31 ハミダ・フォー・ライフ・ベスローテン・フェンノートシャップ Nanoscale electronic detection system and manufacturing method thereof
KR100631213B1 (en) * 2004-05-31 2006-10-04 삼성전자주식회사 Apparatus and method of detecting bio bonding using circuit of inductor
JP3952042B2 (en) * 2004-06-07 2007-08-01 ソニー株式会社 Hybridization detection unit including an electrode having a concave portion and a DNA chip including the detection unit
US8536661B1 (en) 2004-06-25 2013-09-17 University Of Hawaii Biosensor chip sensor protection methods
DE102004031672A1 (en) 2004-06-30 2006-01-19 Infineon Technologies Ag Planar sensor array, sensor array, and method of fabricating a planar sensor array
JP4794832B2 (en) * 2004-07-02 2011-10-19 キヤノン株式会社 Nucleic acid detection probe set and carrier
KR20060009472A (en) * 2004-07-23 2006-02-01 이기방 Systems with water-activated battery
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US7939022B2 (en) * 2004-08-05 2011-05-10 Avago Technologies General Ip (Singapore) Pte. Ltd. Integration of colorimetric transducers and detector
US7169617B2 (en) * 2004-08-19 2007-01-30 Fujitsu Limited Device and method for quantitatively determining an analyte, a method for determining an effective size of a molecule, a method for attaching molecules to a substrate, and a device for detecting molecules
US7420381B2 (en) 2004-09-13 2008-09-02 Cascade Microtech, Inc. Double sided probing structures
ES2345993T3 (en) 2004-09-14 2010-10-07 The Regents Of The University Of Colorado, A Body Corporate METHOD FOR TREATMENT WITH BUCINDOLOL BASED ON GENETIC ADDRESSING.
DE102004045210A1 (en) 2004-09-17 2006-04-06 Infineon Technologies Ag Sensor arrangement and method for determining a sensor event
US7828954B2 (en) * 2004-09-21 2010-11-09 Gamida For Life B.V. Electrode based patterning of thin film self-assembled nanoparticles
US7314542B2 (en) * 2004-09-23 2008-01-01 Nanogen, Inc. Methods and materials for optimization of electronic transportation and hybridization reactions
US8685711B2 (en) * 2004-09-28 2014-04-01 Singulex, Inc. Methods and compositions for highly sensitive detection of molecules
US9040305B2 (en) * 2004-09-28 2015-05-26 Singulex, Inc. Method of analysis for determining a specific protein in blood samples using fluorescence spectrometry
WO2006036182A2 (en) * 2004-09-28 2006-04-06 Singulex, Inc. System and method for spectroscopic analysis of single particles
US7572640B2 (en) * 2004-09-28 2009-08-11 Singulex, Inc. Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties
GB2437753B8 (en) * 2004-10-01 2009-05-20 Nevada System Of Higher Education Cantilevered probe detector with piezoelectric element
DE102004050032A1 (en) * 2004-10-13 2006-04-27 Micronas Gmbh Method for detecting and / or determining the concentration of at least one ligand
US8202479B1 (en) 2004-11-09 2012-06-19 Applied Biosystems, Llc Light collection system
WO2007008246A2 (en) 2004-11-12 2007-01-18 The Board Of Trustees Of The Leland Stanford Junior University Charge perturbation detection system for dna and other molecules
US20060102471A1 (en) 2004-11-18 2006-05-18 Karl Maurer Electrode array device having an adsorbed porous reaction layer
US20060105355A1 (en) * 2004-11-18 2006-05-18 Karl Maurer Electrode array device having an adsorbed porous reaction layer having a linker moiety
DE102004061664A1 (en) * 2004-12-22 2006-07-06 Henkel Kgaa Nucleic acid-binding chips for the detection of phosphate deficiency states in the context of bioprocess control
KR100667339B1 (en) * 2005-01-11 2007-01-12 삼성전자주식회사 Biosensor and biosensor system
US20060166347A1 (en) * 2005-01-27 2006-07-27 Applera Corporation Sample preparation devices and methods
EP1846760B1 (en) * 2005-01-27 2010-12-15 Quest Diagnostics Investments Incorporated Rapid comparative genome hybridization
US7656172B2 (en) 2005-01-31 2010-02-02 Cascade Microtech, Inc. System for testing semiconductors
US7535247B2 (en) 2005-01-31 2009-05-19 Cascade Microtech, Inc. Interface for testing semiconductors
US7910356B2 (en) * 2005-02-01 2011-03-22 Purdue Research Foundation Multiplexed biological analyzer planar array apparatus and methods
US7405831B2 (en) 2005-02-01 2008-07-29 Purdue Research Foundation Laser scanning interferometric surface metrology
US20070023643A1 (en) 2005-02-01 2007-02-01 Nolte David D Differentially encoded biological analyzer planar array apparatus and methods
FR2881363B1 (en) * 2005-02-02 2008-03-14 Commissariat Energie Atomique DEVICE FOR BIOLOGICAL ANALYZES WITH INTEGRATED DETECTOR
KR100624459B1 (en) * 2005-02-03 2006-09-19 삼성전자주식회사 Method for electrically detecting biomolecule
US8569042B2 (en) * 2005-02-23 2013-10-29 Alcatel Lucent DNA structures on ferroelectrics and semiconductors
JP2006234583A (en) * 2005-02-24 2006-09-07 Kyocera Corp Detection board
EP1851331B1 (en) * 2005-02-25 2016-02-24 Commissariat à l'Énergie Atomique et aux Énergies Alternatives Method and device for separating molecular targets in a complex mixture
FR2882563B1 (en) * 2005-02-25 2012-11-02 Commissariat Energie Atomique METHOD AND DEVICE FOR SEPARATING MOLECULAR TARGETS IN A COMPLEX MIXTURE
US20070034513A1 (en) 2005-03-25 2007-02-15 Combimatrix Corporation Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US9164051B2 (en) * 2005-04-06 2015-10-20 Bioscale, Inc. Electrically responsive device
US9394167B2 (en) 2005-04-15 2016-07-19 Customarray, Inc. Neutralization and containment of redox species produced by circumferential electrodes
US20060240443A1 (en) * 2005-04-20 2006-10-26 Combimatrix Corporation Microarray-based single nucleotide polymorphism, sequencing, and gene expression assay method
DE102005019739B3 (en) * 2005-04-28 2006-10-26 Forschungszentrum Rossendorf E.V. Grid sensor for measuring the electric conductivity of a medium flowing in a tube or pipe especially under high temperature and pressure
US20060270053A1 (en) * 2005-05-26 2006-11-30 General Electric Company Apparatus, methods, and systems having gas sensor with catalytic gate and variable bias
US8377398B2 (en) 2005-05-31 2013-02-19 The Board Of Regents Of The University Of Texas System Methods and compositions related to determination and use of white blood cell counts
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US8053774B2 (en) 2005-06-06 2011-11-08 Intel Corporation Method and apparatus to fabricate polymer arrays on patterned wafers using electrochemical synthesis
US8940143B2 (en) 2007-06-29 2015-01-27 Intel Corporation Gel-based bio chip for electrochemical synthesis and electrical detection of polymers
US20060292576A1 (en) * 2005-06-23 2006-12-28 Quest Diagnostics Investments Incorporated Non-in situ hybridization method for detecting chromosomal abnormalities
US20070099211A1 (en) * 2005-07-15 2007-05-03 Vissarion Aivazachvili Detection of nucleic acid amplification
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
WO2007016502A2 (en) 2005-08-02 2007-02-08 Wisconsin Alumni Research Foundation Synthesis of arrays of oligonucleotides and other chain molecules
WO2007019479A2 (en) * 2005-08-04 2007-02-15 Helicos Biosciences Corporation Multi-channel flow cells
US20070037169A1 (en) * 2005-08-09 2007-02-15 Combimatrix Corporation Selective Dehybridization using Electrochemically-Generated Reagent on an Electrode Microarray
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
AU2006287441B2 (en) 2005-09-07 2012-09-06 Sillajen Biotherapeutics, Inc. Systemic treatment of metastatic and/or systemically-disseminated cancers using GM-CSF-expressing poxviruses
JP4918237B2 (en) * 2005-09-08 2012-04-18 株式会社Ｋｒｉ Biological quantification method
US20070065877A1 (en) 2005-09-19 2007-03-22 Combimatrix Corporation Microarray having a base cleavable succinate linker
US20070231794A1 (en) 2005-09-21 2007-10-04 Combimatrix Corporation Process to detect binding events on an electrode microarray using enzymes
CA2623408C (en) * 2005-09-26 2014-04-01 Rapid Micro Biosystems, Inc. Cassette containing growth medium
US8855955B2 (en) 2005-09-29 2014-10-07 Custom Array, Inc. Process and apparatus for measuring binding events on a microarray of electrodes
US20070148045A1 (en) * 2005-10-12 2007-06-28 California Institute Of Technology Optoelectronic system for particle detection
WO2007046484A1 (en) * 2005-10-19 2007-04-26 Sharp Kabushiki Kaisha Electrophoretic chip, electrophoretic device, and electrophoretic system
WO2007050811A2 (en) 2005-10-27 2007-05-03 The President And Fellows Of Harvard College Methods and compositions for labeling nucleic acids
US20080311585A1 (en) * 2005-11-02 2008-12-18 Affymetrix, Inc. System and method for multiplex liquid handling
US8007267B2 (en) * 2005-11-02 2011-08-30 Affymetrix, Inc. System and method for making lab card by embossing
US8075852B2 (en) 2005-11-02 2011-12-13 Affymetrix, Inc. System and method for bubble removal
US20080038714A1 (en) * 2005-11-02 2008-02-14 Affymetrix, Inc. Instrument to Pneumatically Control Lab Cards and Method Thereof
US20070099288A1 (en) * 2005-11-02 2007-05-03 Affymetrix, Inc. Microfluidic Methods, Devices, and Systems for Fluid Handling
JP4825974B2 (en) * 2005-11-17 2011-11-30 国立大学法人京都大学 Fluorescence enhancement element, fluorescence element, and fluorescence enhancement method
KR100738081B1 (en) * 2005-11-22 2007-07-12 삼성전자주식회사 FET based biosensor with inorganic film method for preparing thereof and method for detecting biomolecule using the FET based biosensor
US8076074B2 (en) 2005-11-29 2011-12-13 Quest Diagnostics Investments Incorporated Balanced translocation in comparative hybridization
JP4833654B2 (en) * 2005-12-12 2011-12-07 株式会社カンタム１４ A microreactor with a high-density reaction space array made of porous silicon
EP1963817A2 (en) * 2005-12-22 2008-09-03 Honeywell International Inc. Portable sample analyzer cartridge
US8323570B2 (en) 2006-03-21 2012-12-04 Koninklijke Philips Electronics N.V. Microelectronic sensor device with sensor array
JP4741966B2 (en) * 2006-03-28 2011-08-10 カシオ計算機株式会社 Imaging device, biopolymer analysis chip, gene expression analysis method, and antigen detection method
JP4741967B2 (en) * 2006-03-28 2011-08-10 カシオ計算機株式会社 Gene expression analysis method and antigen detection method
KR100773550B1 (en) * 2006-04-03 2007-11-07 삼성전자주식회사 Method of detecting bio-molecules using field effect transistor without fixing bio-molecules
KR100773549B1 (en) * 2006-04-03 2007-11-07 삼성전자주식회사 Method of detecting bio-molecules using the same field effect transistor
EP3495822B1 (en) 2006-04-04 2023-12-20 Novilux, LLC Method for assessing acute myocardial infarction based on highly sensitive analysis of cardiac troponin
EP3156799B1 (en) 2006-04-04 2024-01-24 Novilux, LLC Analyzer and method for highly sensitive detection of analytes
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
KR101195612B1 (en) * 2006-04-10 2012-10-29 삼성전자주식회사 A field effect transistor comprising a gold layer, a microfluidic device comprising the field effect transistor and a method of detecting an analyte having a thiol group using the field effect transistor and microfluidic device
KR100723426B1 (en) * 2006-04-26 2007-05-30 삼성전자주식회사 Field effect transistor for detecting ionic materials and method of detecting ionic materials using the same
BRPI0711773A2 (en) * 2006-05-24 2011-11-29 Koninkl Philips Electronics Nv imaging apparatus for obtaining a combined spatial image of temperature and luminescence of an associated object, biological detection system, and method for obtaining a special combined image of temperature and luminescence of an object
US7764072B2 (en) 2006-06-12 2010-07-27 Cascade Microtech, Inc. Differential signal probing system
US7723999B2 (en) 2006-06-12 2010-05-25 Cascade Microtech, Inc. Calibration structures for differential signal probing
US7403028B2 (en) 2006-06-12 2008-07-22 Cascade Microtech, Inc. Test structure and probe for differential signals
EP2589668A1 (en) 2006-06-14 2013-05-08 Verinata Health, Inc Rare cell analysis using sample splitting and DNA tags
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
JP4873463B2 (en) * 2006-06-30 2012-02-08 独立行政法人産業技術総合研究所 Detection element having nanogap electrode and detection method using the same
US20080012578A1 (en) * 2006-07-14 2008-01-17 Cascade Microtech, Inc. System for detecting molecular structure and events
US7687103B2 (en) 2006-08-31 2010-03-30 Gamida For Life B.V. Compositions and methods for preserving permeation layers for use on active electronic matrix devices
US8053191B2 (en) 2006-08-31 2011-11-08 Westend Asset Clearinghouse Company, Llc Iterative nucleic acid assembly using activation of vector-encoded traits
US8481023B2 (en) 2006-09-15 2013-07-09 Ottawa Hospital Research Institute Oncolytic rhabdovirus
JP2008102135A (en) * 2006-10-06 2008-05-01 Sharp Corp Microstructure, manufacturing method of the same, and dna assay method
US20080161204A1 (en) * 2006-10-06 2008-07-03 Mo-Huang Li Microwell array for parallel synthesis of chain molecules
US8384136B2 (en) * 2006-10-19 2013-02-26 Hewlett-Packard Development Company, L.P. Demultiplexed nanowire sensor array for detection of chemical and biological species
US7892719B2 (en) * 2006-11-03 2011-02-22 Intel Corporation Photonic crystal EUV photoresists
US7522282B2 (en) 2006-11-30 2009-04-21 Purdue Research Foundation Molecular interferometric imaging process and apparatus
US7807359B2 (en) * 2006-12-01 2010-10-05 Quest Diagnostics Investments Incorporated Methods of detecting TPMT mutations
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
EP2639579B1 (en) 2006-12-14 2016-11-16 Life Technologies Corporation Apparatus for measuring analytes using large scale FET arrays
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8614086B2 (en) * 2006-12-28 2013-12-24 Intel Corporation Quality control methods for the manufacture of polymer arrays
US7923237B2 (en) * 2006-12-28 2011-04-12 Intel Corporation Method and apparatus for combined electrochemical synthesis and detection of analytes
US8999724B2 (en) 2006-12-28 2015-04-07 Intel Corporation Method and apparatus for match quality analysis of analyte binding
US7820454B2 (en) * 2006-12-29 2010-10-26 Intel Corporation Programmable electromagnetic array for molecule transport
US7993525B2 (en) 2006-12-29 2011-08-09 Intel Corporation Device and method for particle complex handling
US7659968B2 (en) * 2007-01-19 2010-02-09 Purdue Research Foundation System with extended range of molecular sensing through integrated multi-modal data acquisition
WO2008118934A1 (en) * 2007-03-26 2008-10-02 Purdue Research Foundation Method and apparatus for conjugate quadrature interferometric detection of an immunoassay
WO2008120169A1 (en) 2007-04-03 2008-10-09 Koninklijke Philips Electronics N. V. Sensor device with magnetic washing means
US20080248900A1 (en) 2007-04-05 2008-10-09 Gus Hernandez Practice baseball swing machine
WO2009031088A1 (en) * 2007-09-06 2009-03-12 Koninklijke Philips Electronics N.V. Method and apparatus for chemical analysis of fluids
JP5026851B2 (en) * 2007-04-23 2012-09-19 株式会社日立製作所 Chemiluminescence detector
ES2307430B1 (en) * 2007-05-09 2009-10-20 Consejo Superior De Investigaciones Cientificas BIOSENSOR AND ITS APPLICATIONS.
KR100801448B1 (en) 2007-05-16 2008-02-11 (주)실리콘화일 Bio chip
JP2009002677A (en) * 2007-06-19 2009-01-08 Hirosaki Univ Surface acoustic wave device biosensor
JP2010533840A (en) * 2007-07-13 2010-10-28 ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニヴァーシティ Methods and apparatus using electric fields for improved biological assays
KR100808114B1 (en) * 2007-07-18 2008-02-29 (주)실리콘화일 Diagnosis device and method of manufacturing the diagnosis device
US7876114B2 (en) 2007-08-08 2011-01-25 Cascade Microtech, Inc. Differential waveguide probe
WO2009023857A1 (en) * 2007-08-15 2009-02-19 State Of Oregon By & Through The State Board Of Higher Education On Behalf Of Portland State Unv. Impedance spectroscopy of biomolecules using functionalized nanoparticles
WO2009029550A2 (en) * 2007-08-24 2009-03-05 Singulex, Inc. Highly sensitive system and methods for analysis of prostate specific antigen (psa)
US8445217B2 (en) 2007-09-20 2013-05-21 Vanderbilt University Free solution measurement of molecular interactions by backscattering interferometry
WO2009040712A2 (en) 2007-09-24 2009-04-02 Koninklijke Philips Electronics N. V. Microelectronic sensor device with an array of detection cells
EP2201136B1 (en) 2007-10-01 2017-12-06 Nabsys 2.0 LLC Nanopore sequencing by hybridization of probes to form ternary complexes and variable range alignment
US7811810B2 (en) 2007-10-25 2010-10-12 Industrial Technology Research Institute Bioassay system including optical detection apparatuses, and method for detecting biomolecules
US7767441B2 (en) * 2007-10-25 2010-08-03 Industrial Technology Research Institute Bioassay system including optical detection apparatuses, and method for detecting biomolecules
US20090112482A1 (en) * 2007-10-26 2009-04-30 Sandstrom Perry L Microarray detector and synthesizer
KR100825087B1 (en) * 2007-11-23 2008-04-25 (주)실리콘화일 Diagnosis device for the biochip of fluorescent type
CN101868915B (en) * 2007-11-28 2013-11-06 株式会社村田制作所 Elastic wave device
US8093063B2 (en) * 2007-11-29 2012-01-10 Quest Diagnostics Investments Incorporated Assay for detecting genetic abnormalities in genomic nucleic acids
US7914734B2 (en) 2007-12-19 2011-03-29 Singulex, Inc. Scanning analyzer for single molecule detection and methods of use
DE102007062250A1 (en) * 2007-12-21 2009-06-25 Evotec Ag Chemical and biological samples e.g. cell, testing device, has set of detecting devices arranged on base element, where each detecting device is attached to individual or group of sample receiving areas
GB0801142D0 (en) * 2008-01-22 2008-02-27 Imp Innovations Ltd Label-free molecule detection and measurement
US20090234202A1 (en) * 2008-03-05 2009-09-17 Goix Philippe J Method and compositions for highly sensitive detection of molecules
BRPI0909791A8 (en) 2008-03-17 2016-08-02 Koninklije Philips Electronics N V CARTRIDGE, SENSING DEVICE AND METHOD FOR DETECTING TARGET COMPONENTS IN A LIQUID SAMPLE, AND, USE OF THE CARTRIDGE OR SENSING DEVICE.
KR100998648B1 (en) * 2008-04-28 2010-12-07 이금필 biosensor
WO2009137369A1 (en) * 2008-05-03 2009-11-12 Tufts Medical Center, Inc. Neonatal salivary genomics
CN102203282B (en) 2008-06-25 2014-04-30 生命技术公司 Methods and apparatus for measuring analytes using large scale FET arrays
EP2307130A1 (en) * 2008-06-27 2011-04-13 STMicroelectronics (Research & Development) Limited Pixel device for biological analysis, cmos biosensor and corresponding fabrication methods
US8697605B2 (en) 2008-06-30 2014-04-15 Intel Corporation Polymer co-location in surface-attached biopolymers and arrays of biopolymers
EP2342362B1 (en) 2008-09-03 2017-03-01 Nabsys 2.0 LLC Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
US8262879B2 (en) 2008-09-03 2012-09-11 Nabsys, Inc. Devices and methods for determining the length of biopolymers and distances between probes bound thereto
US9650668B2 (en) 2008-09-03 2017-05-16 Nabsys 2.0 Llc Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
GB2464183A (en) * 2008-09-19 2010-04-14 Singulex Inc Sandwich assay
US10384203B2 (en) 2008-09-24 2019-08-20 First Light Biosciences, Inc. Kits and devices for detecting analytes
US7888957B2 (en) 2008-10-06 2011-02-15 Cascade Microtech, Inc. Probing apparatus with impedance optimized interface
BRPI0914018A2 (en) 2008-10-16 2015-10-27 Konink Philips Elecronics N V "Method for determining the amount of a target component in a sample, sensor device, computer program product and sensor device usage"
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US8410806B2 (en) 2008-11-21 2013-04-02 Cascade Microtech, Inc. Replaceable coupon for a probing apparatus
US8319503B2 (en) 2008-11-24 2012-11-27 Cascade Microtech, Inc. Test apparatus for measuring a characteristic of a device under test
US8039794B2 (en) * 2008-12-16 2011-10-18 Quest Diagnostics Investments Incorporated Mass spectrometry assay for thiopurine-S-methyl transferase activity and products generated thereby
GB2467338A (en) * 2009-01-30 2010-08-04 Sharp Kk Electrical analyte sensor with optical output
BRPI1012752B1 (en) * 2009-04-20 2019-06-25 Oxford Nanopore Technologies Limited METHOD AND APPARATUS FOR DETECTING AN INTERACTION OF A MOLECULAR ENTITY WITH A MEMBRANE PROTEIN IN A LAYER OF ANFIFYLIC MOLECULES
US8272276B2 (en) * 2009-05-06 2012-09-25 Xsensor Technology Corporation Dielectric textured elastomer in a pressure mapping system
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
US8673627B2 (en) 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
US8574835B2 (en) 2009-05-29 2013-11-05 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
FR2946157B1 (en) 2009-06-02 2015-03-27 Commissariat Energie Atomique MICROLENTILIC IMAGING SYSTEM AND ASSOCIATED DEVICE FOR DETECTING A SAMPLE.
US8450069B2 (en) * 2009-06-08 2013-05-28 Singulex, Inc. Highly sensitive biomarker panels
EP2449104B1 (en) 2009-06-29 2014-06-04 Luminex Corporation Chimeric primers with hairpin conformations and methods of using same
US9409983B2 (en) 2009-07-23 2016-08-09 The Board Of Trustess Of The University Of Illinois Methods and compositions involving PBEF inhibitors for lung inflammation conditions and diseases
KR101258878B1 (en) * 2009-08-28 2013-04-30 한국전자통신연구원 The light addressing bio sensor chip and the driving method thereof
US9512481B2 (en) 2009-09-11 2016-12-06 The Regents Of The University Of Colorado, A Body Corporate Polymorphisms in the PDE3A gene
JP5879266B2 (en) 2009-09-14 2016-03-08 シラジェン バイオセラピューティクス インコーポレイテッド Combined cancer therapy with oncolytic vaccinia virus
CA2774116A1 (en) 2009-09-25 2011-03-31 Signature Genomics Laboratories Llc Multiplex (+/-) stranded arrays and assays for detecting chromosomal abnormalities associated with cancer and other diseases
US9075225B2 (en) 2009-10-28 2015-07-07 Alentic Microscience Inc. Microscopy imaging
US9041790B2 (en) 2009-10-28 2015-05-26 Alentic Microscience Inc. Microscopy imaging
WO2011056872A2 (en) 2009-11-03 2011-05-12 Gen9, Inc. Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
WO2011066185A1 (en) 2009-11-25 2011-06-03 Gen9, Inc. Microfluidic devices and methods for gene synthesis
BR112012013664B1 (en) 2009-12-10 2020-11-10 Turnstone Limited Partnership oncolitic rhabdovirus
CA2822747A1 (en) 2009-12-23 2011-06-30 Arca Biopharma, Inc. Use of s-(6-nitro-oxi-hexahydro-furo[3,2-b]thioacetate in the treatment of cardiovascular disorders associated with oxide synthase dysfunction
JP6017107B2 (en) * 2009-12-28 2016-10-26 ソニー株式会社 Image sensor, manufacturing method thereof, and sensor device
US9217144B2 (en) 2010-01-07 2015-12-22 Gen9, Inc. Assembly of high fidelity polynucleotides
WO2011090793A2 (en) 2010-01-20 2011-07-28 Customarray, Inc. Multiplex microarray of serially deposited biomolecules on a microarray
JP2011232328A (en) * 2010-04-09 2011-11-17 Hitachi Ltd Biological substance detection array, measurement device and measurement method
EP2566971B1 (en) 2010-05-06 2019-03-27 Singulex, Inc. Methods for diagnosing, staging, predicting risk for developing and identifying treatment responders for rheumatoid arthritis
US8383443B2 (en) 2010-05-14 2013-02-26 International Business Machines Corporation Non-uniform gate dielectric charge for pixel sensor cells and methods of manufacturing
US9638632B2 (en) 2010-06-11 2017-05-02 Vanderbilt University Multiplexed interferometric detection system and method
JP2010204126A (en) * 2010-06-23 2010-09-16 Casio Computer Co Ltd Biological macromolecule analysis support device
US8487790B2 (en) 2010-06-30 2013-07-16 Life Technologies Corporation Chemical detection circuit including a serializer circuit
TWI580955B (en) 2010-06-30 2017-05-01 生命技術公司 Ion-sensing charge-accumulation circuits and methods
US20120001646A1 (en) 2010-06-30 2012-01-05 Life Technologies Corporation Methods and apparatus for testing isfet arrays
US11307166B2 (en) 2010-07-01 2022-04-19 Life Technologies Corporation Column ADC
JP5876044B2 (en) 2010-07-03 2016-03-02 ライフ テクノロジーズ コーポレーション Chemically sensitive sensor with lightly doped drain
US9618475B2 (en) 2010-09-15 2017-04-11 Life Technologies Corporation Methods and apparatus for measuring analytes
WO2012039812A1 (en) 2010-09-24 2012-03-29 Life Technologies Corporation Matched pair transistor circuits
US8715933B2 (en) 2010-09-27 2014-05-06 Nabsys, Inc. Assay methods using nicking endonucleases
WO2012051476A1 (en) 2010-10-15 2012-04-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Mid-infrared imaging of microarrays
US9295965B2 (en) 2010-11-12 2016-03-29 Gen9, Inc. Methods and devices for nucleic acid synthesis
US10457935B2 (en) 2010-11-12 2019-10-29 Gen9, Inc. Protein arrays and methods of using and making the same
US8859201B2 (en) 2010-11-16 2014-10-14 Nabsys, Inc. Methods for sequencing a biomolecule by detecting relative positions of hybridized probes
CA2824277C (en) 2011-01-04 2021-08-31 Jennerex, Inc. Generation of antibodies to tumor antigens and generation of tumor specific complement dependent cytotoxicity by administration of oncolytic vaccinia virus
WO2012109574A2 (en) 2011-02-11 2012-08-16 Nabsys, Inc. Assay methods using dna binding proteins
US9562853B2 (en) 2011-02-22 2017-02-07 Vanderbilt University Nonaqueous backscattering interferometric methods
WO2012158238A2 (en) 2011-02-28 2012-11-22 University Of Iowa Research Foundation Anti-müllerian hormone changes in pregnancy and prediction ofadverse pregnancy outcomes and gender
WO2012120377A2 (en) 2011-03-08 2012-09-13 King Abdullah University Of Science And Technology Molecular biomarker set for early detection of ovarian cancer
CN102646592B (en) * 2011-05-03 2014-12-03 京东方科技集团股份有限公司 Thin film field-effect transistor device and preparation method thereof
CA2872045A1 (en) 2011-06-08 2012-12-13 Children's Hospital Of Eastern Ontario Research Institute Inc. Compositions and methods for glioblastoma treatment
AU2012300401B2 (en) 2011-08-26 2018-02-08 Gen9, Inc. Compositions and methods for high fidelity assembly of nucleic acids
EP2565635B1 (en) * 2011-09-02 2017-11-15 Sensirion AG Sensor chip and method for manufacturing a sensor chip
US9229028B2 (en) 2011-09-08 2016-01-05 The Regents Of The University Of California Sensor for low force-noise detection in liquids
WO2013036799A2 (en) 2011-09-09 2013-03-14 Fred Hutchinson Cancer Research Center Methods and compositions involving nkg2d inhibitors and cancer
JP2013092393A (en) * 2011-10-24 2013-05-16 Sony Corp Chemical sensor, biomolecule detection device, and biomolecule detection method
ES2785973T3 (en) 2011-11-07 2020-10-08 Rapid Micro Biosystems Inc Sterility test cassette
DE102011055247A1 (en) 2011-11-10 2013-05-16 Albert-Ludwigs-Universität Freiburg Multianalyt reporter system
US9212381B2 (en) 2011-11-10 2015-12-15 President And Fellows Of Harvard College Methods and compositions for labeling polypeptides
US9970984B2 (en) 2011-12-01 2018-05-15 Life Technologies Corporation Method and apparatus for identifying defects in a chemical sensor array
US8747748B2 (en) 2012-01-19 2014-06-10 Life Technologies Corporation Chemical sensor with conductive cup-shaped sensor surface
US8821798B2 (en) 2012-01-19 2014-09-02 Life Technologies Corporation Titanium nitride as sensing layer for microwell structure
US9150853B2 (en) 2012-03-21 2015-10-06 Gen9, Inc. Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
US8906320B1 (en) 2012-04-16 2014-12-09 Illumina, Inc. Biosensors for biological or chemical analysis and systems and methods for same
US10407707B2 (en) 2012-04-16 2019-09-10 Rapid Micro Biosystems, Inc. Cell culturing device
CN111876409A (en) 2012-04-24 2020-11-03 Gen9股份有限公司 Method for sorting nucleic acids and multiplex preparations in vitro cloning
US9273949B2 (en) 2012-05-11 2016-03-01 Vanderbilt University Backscattering interferometric methods
US8786331B2 (en) 2012-05-29 2014-07-22 Life Technologies Corporation System for reducing noise in a chemical sensor array
CN104685116A (en) 2012-06-25 2015-06-03 Gen9股份有限公司 Methods for nucleic acid assembly and high throughput sequencing
NL1040124C2 (en) * 2012-07-15 2014-09-25 Smart Frequencies B V Method and device for impedance spectroscopy on an array of individual fluild samples present on an array of cavities in at least one printed circuit boards.
US20150276651A1 (en) * 2012-10-30 2015-10-01 Edwards Lifesciences Corporation Analyte sensor and fabrication methods
JP6326058B2 (en) 2012-11-13 2018-05-16 アジレント・テクノロジーズ・インクＡｇｉｌｅｎｔ Ｔｅｃｈｎｏｌｏｇｉｅｓ， Ｉｎｃ． Apparatus, insert and method for three-dimensional tissue measurement on controlled media flow
US9914966B1 (en) 2012-12-20 2018-03-13 Nabsys 2.0 Llc Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation
US9080968B2 (en) 2013-01-04 2015-07-14 Life Technologies Corporation Methods and systems for point of use removal of sacrificial material
US9841398B2 (en) 2013-01-08 2017-12-12 Life Technologies Corporation Methods for manufacturing well structures for low-noise chemical sensors
EP2956550B1 (en) 2013-01-18 2020-04-08 Nabsys 2.0 LLC Enhanced probe binding
US10125373B2 (en) 2013-01-22 2018-11-13 Arizona Board Of Regents On Behalf Of Arizona State University Geminiviral vector for expression of rituximab
US8962366B2 (en) 2013-01-28 2015-02-24 Life Technologies Corporation Self-aligned well structures for low-noise chemical sensors
US10502666B2 (en) 2013-02-06 2019-12-10 Alentic Microscience Inc. Sample processing improvements for quantitative microscopy
MX2015010783A (en) 2013-02-21 2016-06-21 Children S Hospital Of Eastern Ontario Res Inst Inc Vaccine composition.
US8841217B1 (en) 2013-03-13 2014-09-23 Life Technologies Corporation Chemical sensor with protruded sensor surface
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
US9116117B2 (en) 2013-03-15 2015-08-25 Life Technologies Corporation Chemical sensor with sidewall sensor surface
US9835585B2 (en) 2013-03-15 2017-12-05 Life Technologies Corporation Chemical sensor with protruded sensor surface
JP6581074B2 (en) 2013-03-15 2019-09-25 ライフ テクノロジーズ コーポレーション Chemical sensor with consistent sensor surface area
EP2972281B1 (en) 2013-03-15 2023-07-26 Life Technologies Corporation Chemical device with thin conductive element
US9222130B2 (en) * 2013-03-15 2015-12-29 Keith Oxenrider Method and apparatus for sequencing molecules
JP2016510895A (en) 2013-03-15 2016-04-11 ライフ テクノロジーズ コーポレーション Chemical sensor with consistent sensor surface area
US20140336063A1 (en) 2013-05-09 2014-11-13 Life Technologies Corporation Windowed Sequencing
US10458942B2 (en) 2013-06-10 2019-10-29 Life Technologies Corporation Chemical sensor array having multiple sensors per well
US9069358B2 (en) 2013-06-24 2015-06-30 Biolytic Lab Performance, Inc. System for controlling and optimizing reactions in solid phase synthesis of small molecules
CN110058005A (en) 2013-06-26 2019-07-26 阿兰蒂克微科学股份有限公司 It is improved for micro- sample treatment
US9404922B2 (en) 2013-07-15 2016-08-02 The Rockefeller University Recombinant phages and proteins
US20150098940A1 (en) 2013-10-03 2015-04-09 Oklahoma Medical Research Foundation Biomarkers for Systemic Lupus Erythematosus Disease Activity, and Intensity and Flare
GB2519110B (en) 2013-10-09 2018-04-18 Nokia Technologies Oy An apparatus and associated methods for analyte detection
WO2015083749A1 (en) * 2013-12-03 2015-06-11 シャープ株式会社 Sensor chip and biosensor system
MX360883B (en) 2013-12-10 2018-11-21 Illumina Inc Biosensors for biological or chemical analysis and methods of manufacturing the same.
US9572522B2 (en) * 2013-12-20 2017-02-21 Verily Life Sciences Llc Tear fluid conductivity sensor
US10260111B1 (en) 2014-01-20 2019-04-16 Brett Eric Etchebarne Method of detecting sepsis-related microorganisms and detecting antibiotic-resistant sepsis-related microorganisms in a fluid sample
US10520558B2 (en) 2016-01-21 2019-12-31 Lockheed Martin Corporation Diamond nitrogen vacancy sensor with nitrogen-vacancy center diamond located between dual RF sources
US9853837B2 (en) 2014-04-07 2017-12-26 Lockheed Martin Corporation High bit-rate magnetic communication
US9910105B2 (en) 2014-03-20 2018-03-06 Lockheed Martin Corporation DNV magnetic field detector
US9835693B2 (en) 2016-01-21 2017-12-05 Lockheed Martin Corporation Higher magnetic sensitivity through fluorescence manipulation by phonon spectrum control
US9638821B2 (en) 2014-03-20 2017-05-02 Lockheed Martin Corporation Mapping and monitoring of hydraulic fractures using vector magnetometers
US10088336B2 (en) 2016-01-21 2018-10-02 Lockheed Martin Corporation Diamond nitrogen vacancy sensed ferro-fluid hydrophone
US9824597B2 (en) 2015-01-28 2017-11-21 Lockheed Martin Corporation Magnetic navigation methods and systems utilizing power grid and communication network
US10168393B2 (en) 2014-09-25 2019-01-01 Lockheed Martin Corporation Micro-vacancy center device
US9910104B2 (en) 2015-01-23 2018-03-06 Lockheed Martin Corporation DNV magnetic field detector
GB2540308B (en) 2014-04-07 2018-05-16 Lockheed Corp Energy efficient controlled magnetic field generator circuit
JP6739351B2 (en) 2014-06-02 2020-08-12 シーホース バイオサイエンス インコーポレイテッド Single-row microplate system and carrier for biological sample analysis
US9504620B2 (en) 2014-07-23 2016-11-29 American Sterilizer Company Method of controlling a pressurized mattress system for a support structure
CN104297298A (en) * 2014-09-05 2015-01-21 中国科学院上海微系统与信息技术研究所 Peripheral blood circulation tumor cell detection chip and system thereof
EP3224362A4 (en) 2014-11-26 2018-06-06 The Regents of The University of California Therapeutic compositions comprising transcription factors and methods of making and using the same
CN111505087A (en) 2014-12-18 2020-08-07 生命科技公司 Method and apparatus for measuring analytes using large scale FET arrays
US10077472B2 (en) 2014-12-18 2018-09-18 Life Technologies Corporation High data rate integrated circuit with power management
CN107250784B (en) 2014-12-18 2020-10-23 生命科技公司 High data rate integrated circuit with transmitter configuration
JP2018506715A (en) 2015-01-23 2018-03-08 ヴァンダービルト ユニバーシティー Robust interferometer and method of use
WO2016118756A1 (en) 2015-01-23 2016-07-28 Lockheed Martin Corporation Apparatus and method for high sensitivity magnetometry measurement and signal processing in a magnetic detection system
BR112017016261A2 (en) 2015-01-28 2018-03-27 Lockheed Martin Corporation in situ power load
WO2016126436A1 (en) 2015-02-04 2016-08-11 Lockheed Martin Corporation Apparatus and method for recovery of three dimensional magnetic field from a magnetic detection system
GB2550809A (en) 2015-02-04 2017-11-29 Lockheed Corp Apparatus and method for estimating absolute axes' orientations for a magnetic detection system
US10088464B2 (en) * 2015-06-16 2018-10-02 Lunatech, Llc Systems and methods for analyzing pharmaceuticals
US20160370337A1 (en) * 2015-06-16 2016-12-22 Lunatech, Llc Analysis System For Biological Compounds, And Method Of Operation
TWI571626B (en) * 2015-07-15 2017-02-21 力晶科技股份有限公司 Integrated bio-sensor with nanocavity and fabrication method thereof
EP3371614A1 (en) 2015-11-04 2018-09-12 Lockheed Martin Corporation Magnetic band-pass filter
WO2017087013A1 (en) 2015-11-20 2017-05-26 Lockheed Martin Corporation Apparatus and method for closed loop processing for a magnetic detection system
WO2017087014A1 (en) 2015-11-20 2017-05-26 Lockheed Martin Corporation Apparatus and method for hypersensitivity detection of magnetic field
WO2017095454A1 (en) 2015-12-01 2017-06-08 Lockheed Martin Corporation Communication via a magnio
KR101755469B1 (en) * 2015-12-08 2017-07-07 현대자동차 주식회사 Particleate matter detection sensor
WO2017123261A1 (en) 2016-01-12 2017-07-20 Lockheed Martin Corporation Defect detector for conductive materials
WO2017127081A1 (en) 2016-01-21 2017-07-27 Lockheed Martin Corporation Diamond nitrogen vacancy sensor with circuitry on diamond
GB2562193B (en) 2016-01-21 2021-12-22 Lockheed Corp Diamond nitrogen vacancy sensor with common RF and magnetic fields generator
GB2562957A (en) 2016-01-21 2018-11-28 Lockheed Corp Magnetometer with light pipe
AU2016387314A1 (en) 2016-01-21 2018-09-06 Lockheed Martin Corporation Magnetometer with a light emitting diode
WO2017127079A1 (en) 2016-01-21 2017-07-27 Lockheed Martin Corporation Ac vector magnetic anomaly detection with diamond nitrogen vacancies
US10627396B2 (en) 2016-01-29 2020-04-21 Vanderbilt University Free-solution response function interferometry
US10737263B2 (en) * 2016-02-09 2020-08-11 Roswell Biotechnologies, Inc. Electronic label-free DNA and genome sequencing
US10145910B2 (en) 2017-03-24 2018-12-04 Lockheed Martin Corporation Photodetector circuit saturation mitigation for magneto-optical high intensity pulses
US10527746B2 (en) 2016-05-31 2020-01-07 Lockheed Martin Corporation Array of UAVS with magnetometers
US10317279B2 (en) 2016-05-31 2019-06-11 Lockheed Martin Corporation Optical filtration system for diamond material with nitrogen vacancy centers
US10345396B2 (en) 2016-05-31 2019-07-09 Lockheed Martin Corporation Selected volume continuous illumination magnetometer
US10330744B2 (en) 2017-03-24 2019-06-25 Lockheed Martin Corporation Magnetometer with a waveguide
US10338163B2 (en) 2016-07-11 2019-07-02 Lockheed Martin Corporation Multi-frequency excitation schemes for high sensitivity magnetometry measurement with drift error compensation
US10371765B2 (en) 2016-07-11 2019-08-06 Lockheed Martin Corporation Geolocation of magnetic sources using vector magnetometer sensors
US20170343621A1 (en) 2016-05-31 2017-11-30 Lockheed Martin Corporation Magneto-optical defect center magnetometer
US10359479B2 (en) 2017-02-20 2019-07-23 Lockheed Martin Corporation Efficient thermal drift compensation in DNV vector magnetometry
US10571530B2 (en) 2016-05-31 2020-02-25 Lockheed Martin Corporation Buoy array of magnetometers
US10677953B2 (en) 2016-05-31 2020-06-09 Lockheed Martin Corporation Magneto-optical detecting apparatus and methods
US10281550B2 (en) * 2016-11-14 2019-05-07 Lockheed Martin Corporation Spin relaxometry based molecular sequencing
US10228429B2 (en) 2017-03-24 2019-03-12 Lockheed Martin Corporation Apparatus and method for resonance magneto-optical defect center material pulsed mode referencing
US10408890B2 (en) 2017-03-24 2019-09-10 Lockheed Martin Corporation Pulsed RF methods for optimization of CW measurements
US10345395B2 (en) 2016-12-12 2019-07-09 Lockheed Martin Corporation Vector magnetometry localization of subsurface liquids
US10274550B2 (en) 2017-03-24 2019-04-30 Lockheed Martin Corporation High speed sequential cancellation for pulsed mode
WO2018101076A1 (en) * 2016-12-02 2018-06-07 ソニーセミコンダクタソリューションズ株式会社 Semiconductor device, and potential measurement device
CN110462062A (en) 2017-01-26 2019-11-15 俄克拉荷马医学研究基金会 Systemic loupus erythematosus Disease Activity, intensity and the biomarker of acute attack
US11579073B2 (en) 2017-02-07 2023-02-14 Nodexus Inc. Microfluidic system with combined electrical and optical detection for high accuracy particle sorting and methods thereof
US10371760B2 (en) 2017-03-24 2019-08-06 Lockheed Martin Corporation Standing-wave radio frequency exciter
US10459041B2 (en) 2017-03-24 2019-10-29 Lockheed Martin Corporation Magnetic detection system with highly integrated diamond nitrogen vacancy sensor
US10379174B2 (en) 2017-03-24 2019-08-13 Lockheed Martin Corporation Bias magnet array for magnetometer
US10338164B2 (en) 2017-03-24 2019-07-02 Lockheed Martin Corporation Vacancy center material with highly efficient RF excitation
WO2018200123A1 (en) 2017-04-28 2018-11-01 Becton, Dickinson And Company Particle detection cartridges, systems thereof and methods for using the same
WO2019190596A1 (en) * 2017-10-20 2019-10-03 Rutgers, The State University Of New Jersey Transcutaneous wearable apparatus for continuous monitoring of biomarkers in blood
NL2020612B1 (en) 2017-12-22 2019-07-02 Illumina Inc Light detection devices with protective liner and methods of manufacturing same
NL2020625B1 (en) 2017-12-22 2019-07-02 Illumina Inc Two-filter light detection devices and methods of manufacturing same
NL2020615B1 (en) 2017-12-26 2019-07-02 Illumina Inc Image sensor structure
EP3711095B1 (en) 2017-12-26 2024-03-06 Illumina, Inc. Sensor system
WO2020081204A1 (en) 2018-10-18 2020-04-23 Oklahoma Medical Research Foundation Biomarkers for a systemic lupus erythematosus (sle) disease activity immune index that characterizes disease activity
CA3117112A1 (en) 2018-10-31 2020-05-07 Arizona Board Of Regents On Behalf Of The University Of Arizona Biomarkers and methods of use for radiation-induced lung injury
US11143585B2 (en) * 2018-12-28 2021-10-12 National Applied Research Laboratories Photoelectrical device for concentration detection, method for concentration detection thereof and method for testing an antibiotic susceptibility on bacteria
JP2020153783A (en) * 2019-03-19 2020-09-24 株式会社東芝 Sensor
KR102488871B1 (en) * 2020-05-04 2023-01-17 광운대학교 산학협력단 Biosensor and a method for diagnosis prostate cancer using the same
TW202339853A (en) * 2021-12-02 2023-10-16 澳大利亞商量子智產控股有限公司 Apparatus for detecting analytes

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0347579A2 (en) * 1988-06-01 1989-12-27 Daimler-Benz Aerospace Aktiengesellschaft Device having a specific support structure for receiving, analysing and treating samples
WO1990002327A1 (en) * 1988-08-18 1990-03-08 AUSTRALIAN MEMBRANE AND BIOTECHNOLOGY RESEARCH INSTITUTE LTD., Commonwealth Scientific and Industrial Research Organization Improvements in sensitivity and selectivity of ion channel membrane biosensors
WO1990005300A1 (en) * 1988-11-10 1990-05-17 Midwest Research Technologies, Inc. Method for electrical detection of a binding reaction
US4963245A (en) * 1986-05-02 1990-10-16 Ciba Corning Diagnostics Corp. Unitary multiple electrode sensor
WO1990015070A1 (en) * 1989-06-07 1990-12-13 Affymax Technologies N.V. Very large scale immobilized peptide synthesis
EP0402917A2 (en) * 1989-06-15 1990-12-19 Biocircuits Corporation Biosensors employing electrical, optical and mechanical signals
US5187096A (en) * 1991-08-08 1993-02-16 Rensselaer Polytechnic Institute Cell substrate electrical impedance sensor with multiple electrode array

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE347579C (en) * 1918-02-19 1922-01-23 Wilhelm Zurovec Parachute arrangement for screw tether pilots with compressed air shock absorbers
US4054646A (en) * 1973-07-30 1977-10-18 General Electric Method and apparatus for detection of antibodies and antigens
JPS5153893A (en) * 1974-11-07 1976-05-12 Rigaku Denki Co Ltd SEIKAGAKUHANNONETSUSOKUTE ISOCHI
SE407115B (en) * 1975-10-06 1979-03-12 Kabi Ab PROCEDURES AND METAL ELECTRODES FOR THE STUDY OF ENZYMATIC AND OTHER BIOCHEMICAL REACTIONS
US4238757A (en) * 1976-03-19 1980-12-09 General Electric Company Field effect transistor for detection of biological reactions
US4314821A (en) * 1979-04-09 1982-02-09 Minnesota Mining And Manufacturing Company Sandwich immunoassay using piezoelectric oscillator
GB2097692B (en) * 1981-01-10 1985-05-22 Shaw Stewart P D Combining chemical reagents
US4994373A (en) * 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
US4571543A (en) * 1983-03-28 1986-02-18 Southwest Medical Products, Inc. Specific material detection and measuring device
US4580895A (en) * 1983-10-28 1986-04-08 Dynatech Laboratories, Incorporated Sample-scanning photometer
US5221605A (en) * 1984-10-31 1993-06-22 Igen, Inc. Luminescent metal chelate labels and means for detection
US5064754A (en) * 1984-12-14 1991-11-12 Mills Randell L Genomic sequencing method
GB8432069D0 (en) * 1984-12-19 1985-01-30 Iq Bio Ltd Apparatus for immunoassay
US5096807A (en) * 1985-03-06 1992-03-17 Murex Corporation Imaging immunoassay detection system with background compensation and its use
DE3513168A1 (en) * 1985-04-12 1986-10-16 Thomas 8000 München Dandekar BIOSENSOR CONSISTING OF A SEMICONDUCTOR BASED ON SILICON OR CARBON-BASED (ELECTRONIC PART) AND NUCLEIN BASE (OR. OTHER BIOL. MONOMERS)
US4816418A (en) * 1985-07-22 1989-03-28 Sequoia-Turner Corporation Method and apparatus for performing automated, multi-sequential immunoassays
EP0213825A3 (en) * 1985-08-22 1989-04-26 Molecular Devices Corporation Multiple chemically modulated capacitance
US4760105A (en) * 1985-10-09 1988-07-26 Westinghouse Electric Corp. Polyimide modified epoxy resins in aqueous emulsions for lamination and electrodeposition
US4822566A (en) * 1985-11-19 1989-04-18 The Johns Hopkins University Optimized capacitive sensor for chemical analysis and measurement
EP0245477A4 (en) * 1985-11-19 1989-08-09 Univ Johns Hopkins Capacitive sensor for chemical analysis and measurement.
GB2186078A (en) * 1986-01-29 1987-08-05 Iq Method and apparatus for carrying out biochemical assay
US4935207A (en) * 1986-04-01 1990-06-19 The Johns Hopkins University Capacitive chemical sensor using an ion exchange surface
US4728882A (en) * 1986-04-01 1988-03-01 The Johns Hopkins University Capacitive chemical sensor for detecting certain analytes, including hydrocarbons in a liquid medium
US4943471A (en) * 1986-05-20 1990-07-24 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Patterned thin film and process for preparing the same
JPH0634676Y2 (en) * 1986-06-12 1994-09-07 株式会社サイニクス Test solution spectroscopic analyzer
GB8705649D0 (en) * 1987-03-10 1987-04-15 Pa Consulting Services Assay sensor
GB2202045B (en) * 1987-03-10 1991-08-21 Pa Consulting Services Improvements relating to sensors for performing assays
US5202231A (en) * 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5114674A (en) * 1987-05-01 1992-05-19 Biotronic Systems Corporation Added array of molecular chains for interfering with electrical fields
US4769121A (en) * 1987-05-01 1988-09-06 Biotronic Systems Corporation Sintered pellet with biochemically active layer
US5082627A (en) * 1987-05-01 1992-01-21 Biotronic Systems Corporation Three dimensional binding site array for interfering with an electrical field
US4787963A (en) * 1987-05-04 1988-11-29 Syntro Corporation Method and means for annealing complementary nucleic acid molecules at an accelerated rate
US4847193A (en) * 1987-06-18 1989-07-11 Gene-Trak Systems Signal amplification in an assay employing a piezoelectric oscillator
GB8801807D0 (en) * 1988-01-27 1988-02-24 Amersham Int Plc Biological sensors
US4938742A (en) * 1988-02-04 1990-07-03 Smits Johannes G Piezoelectric micropump with microvalves
JPH01221668A (en) * 1988-02-29 1989-09-05 Shimadzu Corp Method and instrument for measuring antigen-antibody reaction
GB8810400D0 (en) * 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US4908112A (en) * 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US5075077A (en) * 1988-08-02 1991-12-24 Abbott Laboratories Test card for performing assays
WO1990001564A1 (en) * 1988-08-09 1990-02-22 Microprobe Corporation Methods for multiple target analyses through nucleic acid hybridization
GB8822228D0 (en) * 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
JP2897027B2 (en) * 1988-10-27 1999-05-31 スズキ株式会社 Immunological agglutination detector
SE462408B (en) * 1988-11-10 1990-06-18 Pharmacia Ab OPTICAL BIOSENSOR SYSTEM USING SURFACE MONITORING RESONSE FOR THE DETECTION OF A SPECIFIC BIOMOLIC CYCLE, TO CALIBRATE THE SENSOR DEVICE AND TO CORRECT FOUND BASELINE OPERATION IN THE SYSTEM
US5200051A (en) * 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5063081A (en) * 1988-11-14 1991-11-05 I-Stat Corporation Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor
EP0376611A3 (en) * 1988-12-30 1992-07-22 The Board Of Trustees Of The Leland Stanford Junior University Electrophoretic system
GB8910958D0 (en) * 1989-05-12 1989-06-28 Bruce Neil C Assay
US5547839A (en) * 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
GB2233654A (en) * 1989-07-07 1991-01-16 Nat Res Dev Immobilised polynucleotides
JPH03282353A (en) * 1990-03-30 1991-12-12 Shimadzu Corp Quantitative determination of dna and rna
DE69115690T2 (en) * 1990-04-11 1996-05-30 Ludwig Inst Cancer Res METHOD AND DEVICE FOR FOLLOWING CHEMICAL REACTION PROCESS
GB2244135B (en) * 1990-05-04 1994-07-13 Gen Electric Co Plc Sensor devices
JP2554727Y2 (en) * 1990-05-18 1997-11-17 スズキ株式会社 Optical device for aggregation pattern determination
AU7997791A (en) * 1990-05-23 1991-12-10 Trustees Of Columbia University In The City Of New York, The Replicatable hybridizable recombinant rna probes and hybridization assay
WO1992004470A1 (en) * 1990-09-12 1992-03-19 Scientific Generics Limited Electrochemical denaturation of double-stranded nucleic acid
JPH06504997A (en) * 1990-12-06 1994-06-09 アフィメトリックス，　インコーポレイテッド Synthesis of immobilized polymers on a very large scale
DE69132843T2 (en) * 1990-12-06 2002-09-12 Affymetrix Inc N D Ges D Staat Identification of nucleic acids in samples
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5384261A (en) * 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963245A (en) * 1986-05-02 1990-10-16 Ciba Corning Diagnostics Corp. Unitary multiple electrode sensor
EP0347579A2 (en) * 1988-06-01 1989-12-27 Daimler-Benz Aerospace Aktiengesellschaft Device having a specific support structure for receiving, analysing and treating samples
WO1990002327A1 (en) * 1988-08-18 1990-03-08 AUSTRALIAN MEMBRANE AND BIOTECHNOLOGY RESEARCH INSTITUTE LTD., Commonwealth Scientific and Industrial Research Organization Improvements in sensitivity and selectivity of ion channel membrane biosensors
WO1990005300A1 (en) * 1988-11-10 1990-05-17 Midwest Research Technologies, Inc. Method for electrical detection of a binding reaction
WO1990015070A1 (en) * 1989-06-07 1990-12-13 Affymax Technologies N.V. Very large scale immobilized peptide synthesis
EP0402917A2 (en) * 1989-06-15 1990-12-19 Biocircuits Corporation Biosensors employing electrical, optical and mechanical signals
US5187096A (en) * 1991-08-08 1993-02-16 Rensselaer Polytechnic Institute Cell substrate electrical impedance sensor with multiple electrode array

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7655129B2 (en) 1998-06-23 2010-02-02 Osmetech Technology Inc. Binding acceleration techniques for the detection of analytes
US8012743B2 (en) 1998-10-27 2011-09-06 Osmetech Technology Inc. Detection of target analytes using particles and electrodes
US9151746B2 (en) 1999-04-21 2015-10-06 Osmetech Technology, Inc. Use of microfluidic systems in the electrochemical detection of target analytes
CN101688862A (en) * 2007-06-27 2010-03-31 （株）赛丽康 Diagnosis device using image sensor and method of manufacturing the same

Also Published As

Publication number Publication date
DE69334108T2 (en) 2007-08-09
EP1143015A3 (en) 2008-07-09
JPH07508831A (en) 1995-09-28
EP0638173B1 (en) 2004-11-10
EP1143015A2 (en) 2001-10-10
EP1143016A2 (en) 2001-10-10
EP1143014B1 (en) 2007-01-17
JP2004004064A (en) 2004-01-08
JP3447055B2 (en) 2003-09-16
JP3711122B2 (en) 2005-10-26
JP2003185662A (en) 2003-07-03
DE69334108D1 (en) 2007-03-08
DE69333687T2 (en) 2005-10-27
US5846708A (en) 1998-12-08
EP0638173A1 (en) 1995-02-15
WO1993022678A2 (en) 1993-11-11
DE69333687D1 (en) 2004-12-16
EP1143014B9 (en) 2007-10-10
EP1143014A3 (en) 2003-11-12
US5653939A (en) 1997-08-05
EP1143014A2 (en) 2001-10-10
EP1143016A3 (en) 2003-11-12

Similar Documents

Publication Publication Date Title
WO1993022678A3 (en) Optical and electrical methods and apparatus for molecule detection
IL103674A0 (en) Method and apparatus for molecule detection
GB2278235B (en) Method and device for biochemical sensing
NZ306051A (en) Testing using electrochemiluminescence
NO20003911D0 (en) Method and apparatus for detecting molecular binding events
CA2226263A1 (en) Apparatus for and method of nuclear quadrupole testing of a sample
EP1318399A3 (en) Passive sample detection to initiate timing of an assay
CA2251942A1 (en) Molecular detection apparatus and method using optical waveguide detection
KR950702707A (en) METHOD OF AND APPARATUS FOR DETERMINING A PROPERTY OF A SAMPLE
HUP0103577A2 (en) Optical disc-based assay devices and methods
NO973381L (en) Diagnostic test device with test layers consisting of several layers, and method for determining an analyte by means of this
BR9612459A (en) Operation process automatic well test system
WO1998002580A3 (en) Signal amplification method
ATE308753T1 (en) METHOD FOR PRODUCING DETECTION SYSTEMS USING PLANAR ARRAYS
JPH03505002A (en) Pyroelectric temperature measuring device
FR2647551B1 (en) ELECTRO-OPTICAL PROBE FOR MEASURING ELECTRICAL SIGNALS OR FIELDS AND ITS APPLICATION
CA2130947A1 (en) Dry Elements, Test Devices, Test Kits and Methods for Chemiluminescent Detection of Analytes Using Peroxidase-Labeled Reagents
AU4927993A (en) Determination of the extent of cross-linking prior to the intentional curing of polymers
AU6513790A (en) Apparatus for detection of an immobilized analyte
FR2438301A1 (en) SIGNAL DETECTION CIRCUIT OF A MAGNETIC SENSOR
WO2000075360A3 (en) Method and apparatus for enzyme detection
CA2027647A1 (en) Method and Apparatus for Characterizing Reflected Ultrasonic Pulses
EP0512620A3 (en) X-ray analysis apparatus
NO166817C (en) TESTING DEVICE FOR DETERMINING THE PRESENCE OF AN ION IN A DIFFICULT TEST.
DE69000071D1 (en) DEVICE FOR DYNAMIC TORSION TESTING OF A SAMPLE.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): CA JP

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): CA JP

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 1993910751

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1993910751

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: CA

WWG Wipo information: grant in national office

Ref document number: 1993910751

Country of ref document: EP