WO1993017754A1 - Drug delivery devices - Google Patents
Drug delivery devices Download PDFInfo
- Publication number
- WO1993017754A1 WO1993017754A1 PCT/EP1993/000562 EP9300562W WO9317754A1 WO 1993017754 A1 WO1993017754 A1 WO 1993017754A1 EP 9300562 W EP9300562 W EP 9300562W WO 9317754 A1 WO9317754 A1 WO 9317754A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- drug
- drug delivery
- reservoir
- tubular elements
- liquid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
- A61N1/303—Constructional details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
Definitions
- the present invention relates to transdermal or interdermal drug delivery devices for delivering a liquid drug to a subject via the subject's skin.
- the invention is particularly useful with respect to the drug delivery device described in our Patent No.5,156,591 , and is therefore described below with respect to that device, but it will be appreciated that the invention could advantageously be used in other types of drug delivery devices.
- Our Patent No.5,156,591 describes a transdermal drug delivery device which delivers a drug to the subject by means of an electrically-induced mass transfer phenomenon called iontophoresis.
- a drug delivery device for delivering a liquid drug to a subject via the subject's skin, comprising: a housing; a liquid reservoir in the housing for a liquid drug to be delivered; and a drug delivery body carried by the housing and having one side communicating with one side of the liquid reservoir, and the opposite side exposed to engage the skin of the subject to receive the drug; characterized in that the drug delivery body includes a plurality of stiff tubular elements extending through the body, each having an inlet end communicating with the liquid reservoir, and an outlet end at said opposite side of the drug delivery body to conduct the liquid drug directly to said opposite side.
- the plurality of stiff tubular elements may be in the form of hollow needles having inner diameters of less than 1 mm and projecting at least 0.1 mm from the face of the drug delivery body.
- the drug delivery body includes at least fifty of such stiff tubular elements or hollow needles. Their tips may be cut at a bias to pierce the outer layer of dead cells on the skin and thereby to enhance the penetration of the drug.
- the plurality of tubular elements are pressed firmly against the subject's skin, and thereby provide a better delivery of the drug to the subject's skin, as compared to the use of microporous or matrix-type drug delivery bodies as in the prior art.
- the device also permits better control of the drug delivery rate. When the delivery is effected by iontophoresis, the better delivery of the drug enables lower electrical currents to be used, thereby decreasing the danger of burning or irritating the subject's skin.
- Fig. 1 is a top plan view illustrating one form of transdermal drug delivery device constructed in accordance with the present invention
- Fig. 2 is a bottom plan view of the device of Fig. 1;
- Fig. 3 is an enlarged sectional view along line Ill-Ill of Fig. 2;
- Figs. 4, 5 and 6 are views similar to that of Fig. 3 but illustrating three further forms of drug delivery devices constructed in accordance with the present invention; and Figs. 7a-7e illustrate various tip constructions of the stiff tubular elements extending through the drug delivery body.
- the transdermal drug delivery device illustrated • in Figs. 1-3 of the drawings, and generally designated 2 is applied by a band 3 to the arm or leg of the subject, with one side of the device (that side illustrated in Fig. 2) firmly pressed against the subject's skin.
- the device 2 is a self-contained unit which includes a reservoir for the liquid drug to be delivered, as well as electrodes for delivering the drug by means of the iontophoresis electrically-induced mass transfer phenomenon.
- Device 2 further includes an electrolytic cell which, together with the iontophoresis electrodes, controls the rate of feed of the drug to the subject, and an electrical battery for powering both the iontophoresis electrodes and the electrolytic cell.
- the internal stucture of the transdermal drug delivery device 2 is more particularly illustrated in Fig. 3. It includes a housing 4 of plastic material and of circular configuration. Housing 4 is made of an inner section 4a, an outer section 4b, and an intermediate section 4c threadedly joining sections 4a and 4b together.
- the inner section 4a is formed with a large circular opening 6, and the outer section 4b is formed with a smaller circular opening 8.
- An inner membrane 10 is clamped between housing sections 4a and 4c, and an outer membrane 12 is clamped between housing sections 4b and 4c.
- Both membranes 10 and 12 are of elastomeric material and include annular flexible sections 10a, 12a, to make them displaceable in response to pressure.
- Membrane 10 is aligned with the center opening 6 in housing section 4a and is clamped between that housing section and the intermediate section 4c via a ring 14.
- Membrane 12 is clamped between the intermediate housing section 4c and the outer housing section 4b via a disc 16 having a central opening 18 in alignment with opening 8 in the outer housing section 4b.
- a third membrane 20 is clamped between disc 16 and the outer housing section 4b to close opening 8.
- Membrane 10 is displaceable outwardly of housing 4 by its annular flexible section 10a, but is restrained against inward displacement by a rigid annular disc 22 integrally formed with the intermediate housing section 4c.
- Membrane 12 is displaceable in both directions by its annular flexible section 12a.
- Membrane 20 is similarly . displaceable in both directions with respect to openings 8 and 18 in housing section 4b and disc 16, respectively.
- the two membranes 10, 12 define, between them, a chamber 24 serving as a liquid reservoir for the liquid drug to be delivered by the device 2.
- Membrane 10 serves as a drug delivery body through which the drug is delivered.
- membrane 10 includes a plurality of tubular elements 26 extending through it, with each tubular element having an inlet end 26a communicating with the liquid reservoir 24, and an outlet end 26b engageable with the subject's skin.
- a second chamber 28 is defined between membrane 12 and disc 16 and its membrane 20.
- Chamber 28 serves as a pressure-control chamber for controlling the pressure applied to the drug chamber 24 for controlling the rate of feed of the liquid drug via tubular elements 26 through the drug delivery membrane 10.
- chamber 28 includes an electrolytic cell, generally designated 30, comprising a pair of electrodes 30a, 30b and an electrolyte 30c which generates a gas in accordance with the current passing through it.
- electrolytic cells are well known and are capable of generating a gas (e.g., oxygen and/or hydrogen) when an electrical current is applied.
- Electrolytic cell 30 is located in one side of a cavity formed in membrane 12. The other side of the cavity serves as a compartment for a button-type battery 32 powering the electrolytic cell 30.
- Electrode 30a of the electrolytic cell is connected to one side of the battery via spring clips 34a and 34b electrically connected together- by lead 34c, all carried by disc 16.
- Electrode 30b of the electrolytic cell is extended so as to engage the other side
- Battery 32 also supplies electrical current to a pair of iontophoresis electrodes 36, 38, to induce the transfer of the drug within compartment 24 via the tubular elements 26 in membrane 10 to the subject's skin.
- Electrode 36 is of annular shape and encloses membrane 10 so as to come into contact with the subject's skin when the device 2 is applied to the subject.
- Electrode 38 is a conductive layer applied to membrane 12 facing the drug compartment 24 so as to come into direct contact with the drug therein.
- the drug is introduced into the drug compartment 24 via an injection port 40 received in an opening on one side of the intermediate housing section 4c.
- a nipple 42 is threadely applied in alignment with an opening in the opposite side of the intermediate housing section 4c and is closed by a hydrophobic filter 44.
- the liquid drug is introduced into drug compartment 24 via an injection syringe piercing plug 40.
- Nipple 42 serves as a vent for purging the air from compartment 24 until the vent is closed by contact of the liquid drug with the hydrophobic filter 44 when the compartment is filled with the drug.
- Membrane 10 is made of a reslient, deformable material.
- the tubular elements 26 passing through membrane 10 are preferably made of a stiff, i.e., rigid or semi-rigid, plastic material having an inner diameter of less than 1.0 mm, and projecting at least 0.1 mm from the outer face of membrane 10.
- these tubular elements 26 may be made of Teflon (Reg. TM) , or of a polycarbonate resin, have an outer diameter of 1.0 mm, an inner diameter of 0.5 mm, and projecting about 0.3 mm from the surface of the drug delivery membrane 10 in contact with the subject's skin.
- they are in the form of hollow metal needles, such as of steel or aluminum coated on their outer suraces with a coating of insulation, e.g., by oxidation, chemical deposition, etc.
- a drug delivery device would usually include at least 50 of such tubular elements, with the outlet ends 26b of each such element firmly engaging the subject's skin so as to effectively seal their inner channels to the subject's skin. These tubular elements thus deliver the drug from compartment 24 directly to a multitude of spaced discrete areas on the subject's skin, and at a rate determined by the pressure applied to the drug chamber 24 by the displacement of membrane 12.
- membranes 10, 12 and 20 may be of a silicone rubber.
- Electrically-conductive layer 38 applied to membrane 12, and/or electrode 36 applied to the subject's skin, may also be of a silicone rubber, but with an electrically-conductive filler such as silver, carbon or aluminum particles.
- the device illustrated in Figs. 1-3 may be applied to the arm or leg of the subject to receive the drug by the use of the bands 3 such that the inner face of the device, illustrated in Fig. 2, firmly engages the subject's skin.
- the outer ends 26b of the stiff tubular elements 26 passing through the drug-delivery membrane 10 project slightly from the membrane and firmly engage the subject's skin.
- Battery 32 supplies electrical current via an electrical switch or other control circuitry (not shown ) to •both the electrolytic cell electrodes 30a, 30b and to the iontophoresis electrodes 36, 38.
- the electrolytic cell 30 generates a gas in accordance with the magnitude of the electrical current applied to its electrolyte 30c. This gas increases the pressure within chamber 28 to displace membrane 12 towards membrane 10, thereby increasing the pressure within the drug chamber 24.
- Membrane 20, having one side exposed to the pressure within chamber -'28 and the other side exposed to the atmosphere, tends to regulate the pressure within chamber 28.
- the displacement of membrane 12 towards the drug delivery membrane 10 forces the liquid drug from compartment 24 through the tubular elements 26 in accordance with the pressure in chamber 24.
- the pressure in chamber 24 also tends to displace membrane 10 outwardly, thereby more firmly 5 pressing the outlet ends 26b of the tubular elements 26 into contact with the subject's skin. It will thus be seen that the rate of feeding of the drug from chamber 24 via tubular elements 26 to the subject's skin will be controlled by the rate of generation of gas by the electrolytic cell 30.
- Electrode 36 directly contacts the subject's skin
- electrode 38 directly contacts the drug within compartment 24 delivered to the subject's skin via the tubular elements 26.
- the delivery of the drug from compartment 24 to the subject's skin is effected in a manner which is both efficient and controllable by controlling the electrical current supplied to the electrolyic cell 30 and also the voltage applied between the two iontophoresis electrodes 36, 38.
- Fig. 4 illustrates another device which is generally similar to that of Fig. 3 but includes a number of changes. To facilitate understanding, the elements in the device of Fig. 4 which are generally similar to those in Fig. 3 are correspondingly numbered.
- the housing 4 is a two-section housing (rather than a three-section housing), including the two sections 4 and 4b threadedly secured together.
- the injection port 40 for introducing the drug into the drug reservoir in compartment 24 is located within an opening in housing section 4a.
- the drug delivery body for delivering the drug from the drug compartment 24 is constituted, not by a displaceable membrane 10, but rather by the rigid wall 50 of housing section 4a, which rigid wall carries the stiff tubular elements 26 communicating with the drug compartment 24.
- the device of Fig. 4 does not include a membrane corresponding to membrane 10 in Fig. 3.
- the device of Fig. 4 does include membranes 12 and 20 defining between them the compartment for the electrolytic cell 30 and battery 32.
- the latter elements instead of being received within a socket formed in membrane 12, are rather received within a socket formed in a rigid holder 52 secured between the two housing sections 4a and 4b.
- the electrolytic cell 30 communicates with chamber 28 between the two membranes 12 and 20, such that the pressure produced in chamber 28 by the gas generated from the electrolytic cell 30, deforms membrane 12 to control the rate of delivery of the drug via the stiff tubular elements 26.
- Membrane 20 in the construction of Fig. 4, is secured between housing section 4b and the rigid holder 50 and carries electrical contact 34c on its inner face engageable with electrical contacts 34a and 34b connecting battery 32 to the electrolytic cell 30 to regulate the pressure of the gas within chamber 28.
- electrical contact 34c on its inner face engageable with electrical contacts 34a and 34b connecting battery 32 to the electrolytic cell 30 to regulate the pressure of the gas within chamber 28.
- FIG. 4 A still further difference in the construction of Fig. 4 over that of Fig. 3 is that, in Fig. 4 the iontophoresis electrodes 36 and 38 are omitted.
- the delivery of the drug from compartment 24 via the stiff tubular elements 26 is controlled by the rate of generation of gas by electrolytic cell 30.
- the device of Fig. 4 is constructed, and operates, in substantially the same manner as described above with respect to Fig. 3.
- Fig. 5 illustrates another device similar to that of Figs. 3 and 4 but further simplified in construction. To facilitate understanding, those parts which are generally similar to those in Figs. 3 and 4 are correspondingly numbered.
- the device in Fig. 5 also includes a two- section housing 4a, 4b, as in Fig. 4, with the stiff tubular elements 28 carried by the rigid end wall 50 of housing section 4a.
- the drug reservoir compartment 24 is defined by a displaceable membrane 62, generally similar to membrane 20 in Figs. 3 and 4, secured between the two housing sections 4a, 4b, and a partition wall 60 within the housing and formed with a metering orifice 64 for metering the flow of the drug from compartment 24 to the stiff tubular elements 28.
- Partition 60 is formed with an annular rib 66, or other rib formation, in order to space it from the ends of the stiff tubular elements 28 and to permit the drug to flow thereto from the reservoir in compartment 24 via the metering orifice 64.
- Fig. 6 illustrates another construction, similar to that of Fig. 5, but even further simplified. Those elements in Fig. 6 which generally correspond to those in Fig. 5 are correspondingly numbered to facilitate understanding.
- the partition 60 including its metering orifice 64, is omitted, and instead the rate of delivery of the drug is controlled by the pressure within the drug reservoir chamber 24.
- the drug is introduced into chamber 24, at the appropriate pressure, via injection port 40, and membrane 62 is displaced outwardly so as to apply a continuous pressure tending to urge the drug to flow from chamber 24 through the stiff tubular elements 28. If the pressure within chamber 24 drops below that needed for delivering the drug at the desired rate, an additional quantity of the drug ma y be introduce d into compartment 24 via injection port 40.
- the outer tips of the stiff tubular elements, therein designated 126 may be cut at a bias , or made conical, to pierce the layer of dead cells on the skin and thereby to enhance the penetration .of the drug.
- Figs . 7a- 7 e illustrate various configurations of tip constructions.
- F ig. 7a illustrates a tip construction 126a of conical configuration
- F ig. 7b illustrates the tip 126b having an inwardly- tapered cut
- Fig. 7c illustrates the tip 126c as cut at a bias
- F ig. 7d illustrates the tip of a flat configuration (similar to that illustrated in Figs . 3-6 )
- Fig. 7 e illustrates the tip 126e as being of frusto- conical configuration.
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- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Electrotherapy Devices (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP93905344A EP0630276B1 (en) | 1992-03-13 | 1993-03-11 | Drug delivery devices |
DE69312916T DE69312916T2 (en) | 1992-03-13 | 1993-03-11 | ACTIVE SUBSTANCE DELIVERY DEVICES |
JP5515346A JPH07508427A (en) | 1992-03-13 | 1993-03-11 | drug delivery device |
AU36325/93A AU3632593A (en) | 1992-03-13 | 1993-03-11 | Drug delivery devices |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85059592A | 1992-03-13 | 1992-03-13 | |
US07/850,595 | 1992-03-13 | ||
US07/981,652 US5279544A (en) | 1990-12-13 | 1992-11-25 | Transdermal or interdermal drug delivery devices |
US07/981,652 | 1992-11-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1993017754A1 true WO1993017754A1 (en) | 1993-09-16 |
Family
ID=27126940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1993/000562 WO1993017754A1 (en) | 1992-03-13 | 1993-03-11 | Drug delivery devices |
Country Status (9)
Country | Link |
---|---|
US (1) | US5279544A (en) |
EP (1) | EP0630276B1 (en) |
JP (1) | JPH07508427A (en) |
AT (1) | ATE156375T1 (en) |
AU (1) | AU3632593A (en) |
CA (1) | CA2131794A1 (en) |
DE (1) | DE69312916T2 (en) |
TW (1) | TW286286B (en) |
WO (1) | WO1993017754A1 (en) |
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US5527288A (en) * | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
WO1996039226A1 (en) * | 1995-06-06 | 1996-12-12 | Genetronics, Inc. | Method of treatment using electroporation-mediated delivery of drugs and genes |
US5858001A (en) * | 1995-12-11 | 1999-01-12 | Elan Medical Technologies Limited | Cartridge-based drug delivery device |
US5997501A (en) * | 1993-11-18 | 1999-12-07 | Elan Corporation, Plc | Intradermal drug delivery device |
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US6797276B1 (en) | 1996-11-14 | 2004-09-28 | The United States Of America As Represented By The Secretary Of The Army | Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response |
JP4153999B2 (en) | 1996-12-20 | 2008-09-24 | アルザ・コーポレーション | Compositions and methods for enhancing transdermal agent flow |
US6527716B1 (en) | 1997-12-30 | 2003-03-04 | Altea Technologies, Inc. | Microporation of tissue for delivery of bioactive agents |
US5848966A (en) * | 1997-03-04 | 1998-12-15 | Graphic Controls Corporation | Medical device easily removed from skin and a method of removal therefrom |
US20040258703A1 (en) * | 1997-11-14 | 2004-12-23 | The Government Of The Us, As Represented By The Secretary Of The Army | Skin-active adjuvants for transcutaneous immunization |
US6918901B1 (en) * | 1997-12-10 | 2005-07-19 | Felix Theeuwes | Device and method for enhancing transdermal agent flux |
EP1911488A3 (en) | 1997-12-11 | 2008-12-03 | Alza Corporation | Device for enhancing transdermal agent flux |
WO1999029364A1 (en) | 1997-12-11 | 1999-06-17 | Alza Corporation | Device for enhancing transdermal agent flux |
DK1037686T3 (en) | 1997-12-11 | 2006-01-02 | Alza Corp | Apparatus for enhancing transdermal flow of agents |
WO1999029298A2 (en) | 1997-12-11 | 1999-06-17 | Alza Corporation | Device for enhancing transdermal agent flux |
US6208893B1 (en) * | 1998-01-27 | 2001-03-27 | Genetronics, Inc. | Electroporation apparatus with connective electrode template |
US5957895A (en) | 1998-02-20 | 1999-09-28 | Becton Dickinson And Company | Low-profile automatic injection device with self-emptying reservoir |
US6091975A (en) * | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
CA2330207C (en) * | 1998-06-10 | 2005-08-30 | Georgia Tech Research Corporation | Microneedle devices and methods of manufacture and use thereof |
US6678556B1 (en) * | 1998-07-13 | 2004-01-13 | Genetronics, Inc. | Electrical field therapy with reduced histopathological change in muscle |
EP2428250A1 (en) * | 1998-07-13 | 2012-03-14 | Genetronics, Inc. | Skin and muscle-targeted gene therapy by pulsed electrical field |
US7922709B2 (en) | 1998-07-13 | 2011-04-12 | Genetronics, Inc. | Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation |
EP1102608A4 (en) * | 1998-07-13 | 2008-09-17 | Genetronics Inc | Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications |
US7048723B1 (en) * | 1998-09-18 | 2006-05-23 | The University Of Utah Research Foundation | Surface micromachined microneedles |
DE60018726T2 (en) | 1999-04-16 | 2006-04-13 | Johnson & Johnson Consumer Companies, Inc. | DEVICE FOR IONTOPHORETIC ADMINISTRATION OF MEDICAMENTS WITH INTERNAL SENSORS |
US6312612B1 (en) | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
US20030078499A1 (en) * | 1999-08-12 | 2003-04-24 | Eppstein Jonathan A. | Microporation of tissue for delivery of bioactive agents |
US6179804B1 (en) | 1999-08-18 | 2001-01-30 | Oxypatch, Llc | Treatment apparatus for wounds |
US20020156453A1 (en) * | 1999-10-14 | 2002-10-24 | Pettis Ronald J. | Method and device for reducing therapeutic dosage |
US20020095134A1 (en) * | 1999-10-14 | 2002-07-18 | Pettis Ronald J. | Method for altering drug pharmacokinetics based on medical delivery platform |
ES2248165T3 (en) * | 1999-11-15 | 2006-03-16 | Velcro Industries B.V. | SKIN FIXING ELEMENT. |
DE60024312T2 (en) | 1999-12-10 | 2006-08-17 | Alza Corp., Mountain View | Transdermal drug delivery of macromolecular agents and device therefor |
ATE295200T1 (en) | 1999-12-10 | 2005-05-15 | Alza Corp | SKIN TREATMENT DEVICE FOR PROLONGED TRANSDERMAL ADMINISTRATION OF MEDICATIONS |
JP2003516798A (en) | 1999-12-16 | 2003-05-20 | アルザ・コーポレーション | Device for increasing the transdermal flow rate of extracted drugs |
US7473244B2 (en) * | 2000-06-02 | 2009-01-06 | The University Of Utah Research Foundation | Active needle devices with integrated functionality |
US6607513B1 (en) * | 2000-06-08 | 2003-08-19 | Becton, Dickinson And Company | Device for withdrawing or administering a substance and method of manufacturing a device |
US20050008683A1 (en) * | 2000-06-29 | 2005-01-13 | Becton Dickinson And Company | Method for delivering interferons to the intradermal compartment |
US20040175360A1 (en) * | 2000-06-29 | 2004-09-09 | Pettis Ronald J. | Method for altering drug pharmacokinetics based on medical delivery platform |
US6656147B1 (en) * | 2000-07-17 | 2003-12-02 | Becton, Dickinson And Company | Method and delivery device for the transdermal administration of a substance |
US6952605B1 (en) * | 2000-08-10 | 2005-10-04 | Respironics, Inc. | Pneumatic release mechanism for a patient contacting article |
WO2002015960A2 (en) * | 2000-08-21 | 2002-02-28 | The Cleveland Clinic Foundation | Microneedle array module and method of fabricating the same |
MXPA03001694A (en) | 2000-08-24 | 2004-11-01 | Johnson & Johnson | Method for transdermal nucleic acid sampling. |
US6749575B2 (en) | 2001-08-20 | 2004-06-15 | Alza Corporation | Method for transdermal nucleic acid sampling |
US6690959B2 (en) | 2000-09-01 | 2004-02-10 | Medtronic, Inc. | Skin-mounted electrodes with nano spikes |
NZ524646A (en) | 2000-09-08 | 2004-10-29 | Alza Corp | Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure |
WO2002030506A2 (en) | 2000-10-12 | 2002-04-18 | Ink Jet Technology Ltd. | Transdermal method |
US7419481B2 (en) * | 2000-10-13 | 2008-09-02 | Alza Corporation | Apparatus and method for piercing skin with microprotrusions |
JP4659332B2 (en) * | 2000-10-13 | 2011-03-30 | アルザ・コーポレーシヨン | Apparatus and method for perforating skin using microprojections |
BR0114634A (en) * | 2000-10-13 | 2004-01-27 | Alza Corp | Micro Blade Array Impact Applicator |
US7131987B2 (en) * | 2000-10-16 | 2006-11-07 | Corium International, Inc. | Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation |
ES2310201T3 (en) * | 2001-02-13 | 2009-01-01 | Government Of The United States Of America, As Represented By The Secretary Of The Army | VACCINE FOR TRANSCUTANEOUS IMMUNIZATION AGAINST TRAVELERS 'DIARRHEA. |
WO2002074173A1 (en) * | 2001-03-16 | 2002-09-26 | Alza Corporation | Method and apparatus for coating skin piercing microprojections |
JP2004525713A (en) * | 2001-04-13 | 2004-08-26 | ベクトン・ディキンソン・アンド・カンパニー | Methods and devices for administering substances into the intradermal layer of the skin for systemic absorption |
US6767341B2 (en) * | 2001-06-13 | 2004-07-27 | Abbott Laboratories | Microneedles for minimally invasive drug delivery |
US20030073609A1 (en) * | 2001-06-29 | 2003-04-17 | Pinkerton Thomas C. | Enhanced pharmacokinetic profile of intradermally delivered substances |
JP2004531578A (en) * | 2001-06-29 | 2004-10-14 | ベクトン・ディキンソン・アンド・カンパニー | Intradermal delivery of vaccines and gene therapeutics by microcannula |
US20050010193A1 (en) * | 2002-05-06 | 2005-01-13 | Laurent Philippe E. | Novel methods for administration of drugs and devices useful thereof |
JP4383168B2 (en) * | 2001-09-12 | 2009-12-16 | ベクトン・ディキンソン・アンド・カンパニー | Microneedle administration device and drug administration device |
US20040087992A1 (en) * | 2002-08-09 | 2004-05-06 | Vladimir Gartstein | Microstructures for delivering a composition cutaneously to skin using rotatable structures |
CA2500452A1 (en) * | 2001-09-28 | 2003-04-03 | Biovalve Technologies, Inc. | Switchable microneedle arrays and systems and methods relating to same |
US20030135201A1 (en) * | 2001-09-28 | 2003-07-17 | Gonnelli Robert R. | Microneedle with membrane |
US6689100B2 (en) | 2001-10-05 | 2004-02-10 | Becton, Dickinson And Company | Microdevice and method of delivering or withdrawing a substance through the skin of an animal |
US20040120964A1 (en) * | 2001-10-29 | 2004-06-24 | Mikszta John A. | Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses |
US20030199810A1 (en) * | 2001-11-30 | 2003-10-23 | Trautman Joseph Creagan | Methods and apparatuses for forming microprojection arrays |
US20040073175A1 (en) * | 2002-01-07 | 2004-04-15 | Jacobson James D. | Infusion system |
US9918665B2 (en) | 2002-03-11 | 2018-03-20 | Nitto Denko Corporation | Transdermal porator and patch system and method for using same |
AU2003220143A1 (en) * | 2002-03-11 | 2003-09-29 | Altea Therapeutics Corporation | Transdermal integrated actuator device, methods of making and using same |
US8116860B2 (en) | 2002-03-11 | 2012-02-14 | Altea Therapeutics Corporation | Transdermal porator and patch system and method for using same |
ES2406711T3 (en) | 2002-03-26 | 2013-06-07 | Becton, Dickinson And Company | Multi-stage fluid supply device |
US6780171B2 (en) | 2002-04-02 | 2004-08-24 | Becton, Dickinson And Company | Intradermal delivery device |
US7115108B2 (en) * | 2002-04-02 | 2006-10-03 | Becton, Dickinson And Company | Method and device for intradermally delivering a substance |
US7047070B2 (en) * | 2002-04-02 | 2006-05-16 | Becton, Dickinson And Company | Valved intradermal delivery device and method of intradermally delivering a substance to a patient |
US20060264886A9 (en) * | 2002-05-06 | 2006-11-23 | Pettis Ronald J | Method for altering insulin pharmacokinetics |
EP3375463A1 (en) | 2002-05-06 | 2018-09-19 | Becton, Dickinson and Company | Method and device for controlling drug pharmacokinetics |
US6945952B2 (en) | 2002-06-25 | 2005-09-20 | Theraject, Inc. | Solid solution perforator for drug delivery and other applications |
US20040062813A1 (en) * | 2002-06-28 | 2004-04-01 | Cormier Michel J. N. | Transdermal drug delivery devices having coated microprotrusions |
MXPA05000597A (en) * | 2002-07-19 | 2005-04-28 | 3M Innovative Properties Co | Microneedle devices and microneedle delivery apparatus. |
CN100479875C (en) * | 2002-07-22 | 2009-04-22 | 贝克顿·迪金森公司 | Patch-like infusion device |
JP2005537054A (en) * | 2002-08-30 | 2005-12-08 | ベクトン・ディキンソン・アンド・カンパニー | Methods for controlling the pharmacokinetics of immunomodulatory compounds |
CN1723053A (en) * | 2002-09-12 | 2006-01-18 | 儿童医院医疗中心 | Method and device for painless injection of medication |
AU2003275311A1 (en) * | 2002-09-16 | 2004-04-30 | Sung-Yun Kwon | Solid micro-perforators and methods of use |
CA2516547A1 (en) | 2002-09-30 | 2004-04-15 | Alza Corporation | Drug delivery device having coated microprojections incorporating vasoconstrictors |
US20040106904A1 (en) * | 2002-10-07 | 2004-06-03 | Gonnelli Robert R. | Microneedle array patch |
AR042815A1 (en) * | 2002-12-26 | 2005-07-06 | Alza Corp | ACTIVE AGENT SUPPLY DEVICE THAT HAS COMPOUND MEMBERS |
KR100562498B1 (en) * | 2003-02-12 | 2006-03-21 | 삼성전자주식회사 | Pad conditioner of cmp equipment |
US7578954B2 (en) * | 2003-02-24 | 2009-08-25 | Corium International, Inc. | Method for manufacturing microstructures having multiple microelements with through-holes |
AU2004264839B2 (en) * | 2003-06-13 | 2009-06-04 | Becton, Dickinson And Company | Improved intra-dermal delivery of biologically active agents |
TW200518771A (en) | 2003-06-30 | 2005-06-16 | Alza Corp | Formulations for coated microprojections containing non-volatile counterions |
US20050123507A1 (en) * | 2003-06-30 | 2005-06-09 | Mahmoud Ameri | Formulations for coated microprojections having controlled solubility |
JP5174347B2 (en) * | 2003-06-30 | 2013-04-03 | アルザ・コーポレーシヨン | Method for coating microprojections penetrating skin |
CA2535138C (en) | 2003-08-12 | 2013-01-08 | Becton, Dickinson And Company | Patch-like infusion device |
WO2005023328A2 (en) * | 2003-08-26 | 2005-03-17 | Becton Dickinson And Company | Methods for intradermal delivery of therapeutics agents |
US7320676B2 (en) * | 2003-10-02 | 2008-01-22 | Medtronic, Inc. | Pressure sensing in implantable medical devices |
US8323244B2 (en) * | 2007-03-30 | 2012-12-04 | Medtronic, Inc. | Catheter malfunction determinations using physiologic pressure |
US9138537B2 (en) | 2003-10-02 | 2015-09-22 | Medtronic, Inc. | Determining catheter status |
US9033920B2 (en) * | 2003-10-02 | 2015-05-19 | Medtronic, Inc. | Determining catheter status |
CN101415443A (en) * | 2003-10-23 | 2009-04-22 | 阿尔扎公司 | Compositions of stabilized DNA for coating microprojctions |
US7022116B2 (en) * | 2003-10-23 | 2006-04-04 | Medtronic, Inc. | Method for monitoring bolus delivery |
US8016811B2 (en) | 2003-10-24 | 2011-09-13 | Altea Therapeutics Corporation | Method for transdermal delivery of permeant substances |
MXPA06005510A (en) * | 2003-11-13 | 2006-12-14 | Johnson & Johnson | Composition and apparatus for transdermal delivery. |
EP1694400A1 (en) * | 2003-11-28 | 2006-08-30 | Acrux DDS Pty Ltd | Method and system for rapid transdermal administration |
US8017145B2 (en) * | 2003-12-22 | 2011-09-13 | Conopco, Inc. | Exfoliating personal care wipe article containing an array of projections |
WO2005091922A2 (en) * | 2004-03-03 | 2005-10-06 | Becton, Dickinson And Company | Methods and devices for improving delivery of a substance to skin |
WO2005094526A2 (en) * | 2004-03-24 | 2005-10-13 | Corium International, Inc. | Transdermal delivery device |
BRPI0509897A (en) * | 2004-04-13 | 2007-08-07 | Alza Corp | apparatus and method for transdermal delivery of multiple vaccines |
US7217251B2 (en) * | 2004-04-22 | 2007-05-15 | Medtronic, Inc. | Pressure relief methods in a medical catheter system |
WO2005106298A1 (en) * | 2004-04-22 | 2005-11-10 | Medtronic, Inc. | Catheter systems having flow restrictors |
WO2005115360A2 (en) * | 2004-05-11 | 2005-12-08 | Becton, Dickinson And Company | Formulations of anti-pain agents and methods of using the same |
US20060030811A1 (en) * | 2004-08-03 | 2006-02-09 | Wong Patrick S | Method and device for enhancing transdermal agent flux |
EP2388078B1 (en) | 2004-11-18 | 2013-03-20 | 3M Innovative Properties Co. | Method of contact coating a microneedle array |
AU2005306426B2 (en) * | 2004-11-18 | 2011-04-28 | 3M Innovative Properties Company | Masking method for coating a microneedle array |
ATE504328T1 (en) * | 2004-11-18 | 2011-04-15 | 3M Innovative Properties Co | MICRONEEDLE ARRANGEMENT APPLICATOR AND HOLDER |
US8057842B2 (en) | 2004-11-18 | 2011-11-15 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
US20070270738A1 (en) * | 2005-04-25 | 2007-11-22 | Wu Jeffrey M | Method of treating ACNE with stratum corneum piercing patch |
US20060253078A1 (en) * | 2005-04-25 | 2006-11-09 | Wu Jeffrey M | Method of treating skin disorders with stratum corneum piercing device |
US20080009802A1 (en) * | 2005-04-25 | 2008-01-10 | Danilo Lambino | Method of treating acne with stratum corneum piercing device |
DE102005024151A1 (en) * | 2005-05-23 | 2006-11-30 | Thomas Nicola | Device for peritoneal dialysis |
DK1940459T3 (en) * | 2005-09-06 | 2014-05-26 | Theraject Inc | SOLID SOLUTION PERFORATOR CONTAINING ACTIVE SUBSTANCE PARTICLES AND / OR ACTIVE SUBSTANCED PARTICLES |
CN101267896A (en) * | 2005-09-12 | 2008-09-17 | 阿尔扎公司 | Coatable transdermal delivery microprojection assembly |
US20070066934A1 (en) * | 2005-09-19 | 2007-03-22 | Transport Pharmaceuticals, Inc. | Electrokinetic delivery system and methods therefor |
US20070185432A1 (en) * | 2005-09-19 | 2007-08-09 | Transport Pharmaceuticals, Inc. | Electrokinetic system and method for delivering methotrexate |
US7842008B2 (en) * | 2005-11-21 | 2010-11-30 | Becton, Dickinson And Company | Intradermal delivery device |
US7658728B2 (en) * | 2006-01-10 | 2010-02-09 | Yuzhakov Vadim V | Microneedle array, patch, and applicator for transdermal drug delivery |
EP2030643A1 (en) * | 2006-04-06 | 2009-03-04 | Medtronic, Inc. | Systems and methods for identifying catheter malfunctions using pressure sensing |
WO2007127811A2 (en) * | 2006-04-25 | 2007-11-08 | Alza Corporation | Microprojection array application with grouped microprojections for high drug loading |
US20070299388A1 (en) * | 2006-04-25 | 2007-12-27 | Alza Corporation | Microprojection array application with multilayered microprojection member for high drug loading |
CN101528830A (en) | 2006-07-10 | 2009-09-09 | 麦德医像公司 | Super elastic epoxy hydrogel |
US8142426B2 (en) * | 2006-10-16 | 2012-03-27 | Syneron Medical Ltd. | Methods and devices for treating tissue |
US8007493B2 (en) * | 2006-10-16 | 2011-08-30 | Syneron Medical Ltd. | Methods and devices for treating tissue |
US8133216B2 (en) * | 2006-10-16 | 2012-03-13 | Syneron Medical Ltd. | Methods and devices for treating tissue |
US20080281389A1 (en) * | 2006-10-16 | 2008-11-13 | Primaeva Medical Inc. | Methods and devices for treating tissue |
US8273080B2 (en) * | 2006-10-16 | 2012-09-25 | Syneron Medical Ltd. | Methods and devices for treating tissue |
CA2676221C (en) * | 2007-01-22 | 2016-12-20 | Corium International, Inc. | Applicators for microneedles |
EP2125073A1 (en) * | 2007-03-02 | 2009-12-02 | TecPharma Licensing AG | Modular administration system |
US9044537B2 (en) | 2007-03-30 | 2015-06-02 | Medtronic, Inc. | Devices and methods for detecting catheter complications |
US20080312647A1 (en) * | 2007-06-15 | 2008-12-18 | Primaeva Medical, Inc. | Methods and devices for treating tissue |
US8845630B2 (en) * | 2007-06-15 | 2014-09-30 | Syneron Medical Ltd | Devices and methods for percutaneous energy delivery |
US20090036958A1 (en) * | 2007-08-01 | 2009-02-05 | Primaeva Medical, Inc. | Methods and devices for treating tissue |
JP5178132B2 (en) * | 2007-10-11 | 2013-04-10 | キヤノン株式会社 | Image processing system and image processing method |
US20090112205A1 (en) * | 2007-10-31 | 2009-04-30 | Primaeva Medical, Inc. | Cartridge electrode device |
US9995295B2 (en) | 2007-12-03 | 2018-06-12 | Medipacs, Inc. | Fluid metering device |
US20090156958A1 (en) * | 2007-12-12 | 2009-06-18 | Mehta Bankim H | Devices and methods for percutaneous energy delivery |
AU2009249610B2 (en) * | 2008-05-21 | 2014-01-16 | Theraject, Inc. | Method of manufacturing solid solution perforator patches and uses thereof |
EP2307546A1 (en) * | 2008-06-04 | 2011-04-13 | Coda Therapeutics, Inc. | Treatment of pain with gap junction modulation compounds |
US8784360B2 (en) * | 2009-01-21 | 2014-07-22 | Medtronic, Inc. | Catheter systems having flow restrictors |
US20100217254A1 (en) * | 2009-02-25 | 2010-08-26 | Primaeva Medical, Inc. | Methods for applying energy to tissue using isolated energy sources |
WO2010124255A2 (en) * | 2009-04-24 | 2010-10-28 | Corium International, Inc. | Methods for manufacturing microprojection arrays |
US20100286600A1 (en) * | 2009-05-08 | 2010-11-11 | Bommannan D Bommi | Transdermal patch device |
US9238102B2 (en) | 2009-09-10 | 2016-01-19 | Medipacs, Inc. | Low profile actuator and improved method of caregiver controlled administration of therapeutics |
WO2011075104A1 (en) | 2009-12-16 | 2011-06-23 | Becton, Dickinson And Company | Self-injection device |
DK2781228T3 (en) | 2009-12-16 | 2016-03-21 | Becton Dickinson Co | A device for self-injection |
JP5650241B2 (en) | 2009-12-16 | 2015-01-07 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | Self injection device |
US9833562B2 (en) | 2009-12-16 | 2017-12-05 | Becton, Dickinson And Company | Self-injection device |
US9555187B2 (en) | 2009-12-16 | 2017-01-31 | Becton, Dickinson And Company | Self-injection device |
WO2011075103A1 (en) | 2009-12-16 | 2011-06-23 | Becton, Dickinson And Company | Self-injection device |
US20110172637A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Drug delivery device including tissue support structure |
US20110172645A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Wearable drug delivery device including integrated pumping and activation elements |
US20110172639A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Device and method for delivery of microneedle to desired depth within the skin |
US20110172609A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Microneedle component assembly for drug delivery device |
US9500186B2 (en) | 2010-02-01 | 2016-11-22 | Medipacs, Inc. | High surface area polymer actuator with gas mitigating components |
EP2547328B1 (en) * | 2010-02-11 | 2017-06-07 | Ecole Polytechnique Federale de Lausanne (EPFL) | Ccr7 ligand delivery and co-delivery in immunotherapy |
US8926568B2 (en) * | 2010-05-20 | 2015-01-06 | Shl Group Ab | Medicament delivery device comprising a manual activation member with improved gripping and activation abilities |
EP2611478B1 (en) | 2010-09-02 | 2022-08-17 | Becton, Dickinson and Company | Self-injection device having needle cover with activation preventer |
WO2012061556A1 (en) | 2010-11-03 | 2012-05-10 | Flugen, Inc. | Wearable drug delivery device having spring drive and sliding actuation mechanism |
US8636696B2 (en) | 2011-06-10 | 2014-01-28 | Kimberly-Clark Worldwide, Inc. | Transdermal device containing microneedles |
US10000605B2 (en) | 2012-03-14 | 2018-06-19 | Medipacs, Inc. | Smart polymer materials with excess reactive molecules |
CN104736709A (en) | 2012-03-27 | 2015-06-24 | 科达治疗公司 | Compositions and treatments based on cadherin modulation |
US9314505B2 (en) | 2012-05-18 | 2016-04-19 | Otago Innovation Limited | Combination treatments and compositions for wound healing comprising viral VEGF |
EP2961471B1 (en) | 2013-02-28 | 2023-10-25 | Sorrento Therapeutics, Inc. | Transdermal drug delivery device |
US9861801B2 (en) | 2013-02-28 | 2018-01-09 | Kimberly-Clark Worldwide, Inc. | Drug delivery device |
US9539382B2 (en) | 2013-03-12 | 2017-01-10 | Medtronic, Inc. | Stepped catheters with flow restrictors and infusion systems using the same |
US20140350518A1 (en) | 2013-05-23 | 2014-11-27 | Allergan, Inc. | Syringe extrusion accessory |
US20140350516A1 (en) | 2013-05-23 | 2014-11-27 | Allergan, Inc. | Mechanical syringe accessory |
WO2015017561A1 (en) | 2013-07-30 | 2015-02-05 | Zosano Pharma, Inc. | Low-profile microneedle patch applicator |
MX2016013187A (en) | 2014-04-30 | 2017-01-16 | Kimberly Clark Co | Controller portion of transdermal drug delivery apparatus and methods. |
RU2667305C2 (en) | 2014-04-30 | 2018-09-18 | Кимберли-Кларк Ворлдвайд, Инк. | Receptacle portion of transdermal drug delivery apparatus and methods |
WO2015168210A1 (en) | 2014-04-30 | 2015-11-05 | Kimberly-Clark Worldwide, Inc. | Transdermal drug delivery apparatus and methods |
US10029048B2 (en) | 2014-05-13 | 2018-07-24 | Allergan, Inc. | High force injection devices |
US10226585B2 (en) | 2014-10-01 | 2019-03-12 | Allergan, Inc. | Devices for injection and dosing |
CN107530490B (en) | 2015-03-10 | 2021-06-25 | 爱力根销售有限责任公司 | Multi-needle syringe |
KR102288170B1 (en) | 2016-04-08 | 2021-08-09 | 알레간 인코포레이티드 | Aspiration and injection device |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
JP6608336B2 (en) * | 2016-06-06 | 2019-11-20 | 三島光産株式会社 | Microneedle array |
USD867582S1 (en) | 2017-03-24 | 2019-11-19 | Allergan, Inc. | Syringe device |
JP2019013524A (en) * | 2017-07-07 | 2019-01-31 | 凸版印刷株式会社 | Microneedle |
USD933219S1 (en) | 2018-07-13 | 2021-10-12 | Intarcia Therapeutics, Inc. | Implant removal tool and assembly |
CN114028718B (en) * | 2021-12-06 | 2022-05-17 | 湖南省万卓医疗器械有限公司 | Magnetic transmission composite treatment device based on data analysis |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2562800A1 (en) * | 1984-04-11 | 1985-10-18 | Fournier Laboratoires | Device for percutaneous administration of medicaments |
EP0429842A2 (en) * | 1989-10-27 | 1991-06-05 | Korea Research Institute Of Chemical Technology | Device for the transdermal administration of protein or peptide drug |
US5090963A (en) * | 1990-10-19 | 1992-02-25 | Product Development (Z.G.S.) Ltd. | Electrochemically driven metering medicament dispenser |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4921475A (en) * | 1983-08-18 | 1990-05-01 | Drug Delivery Systems Inc. | Transdermal drug patch with microtubes |
US4886514A (en) * | 1985-05-02 | 1989-12-12 | Ivac Corporation | Electrochemically driven drug dispenser |
SU1296174A1 (en) * | 1985-06-20 | 1987-03-15 | Устиновский Государственный Медицинский Институт | Apparatus for electrophoresis of medicines |
-
1992
- 1992-11-25 US US07/981,652 patent/US5279544A/en not_active Expired - Lifetime
-
1993
- 1993-03-11 WO PCT/EP1993/000562 patent/WO1993017754A1/en active IP Right Grant
- 1993-03-11 AU AU36325/93A patent/AU3632593A/en not_active Abandoned
- 1993-03-11 CA CA002131794A patent/CA2131794A1/en not_active Abandoned
- 1993-03-11 AT AT93905344T patent/ATE156375T1/en active
- 1993-03-11 EP EP93905344A patent/EP0630276B1/en not_active Expired - Lifetime
- 1993-03-11 JP JP5515346A patent/JPH07508427A/en active Pending
- 1993-03-11 DE DE69312916T patent/DE69312916T2/en not_active Expired - Fee Related
- 1993-03-12 TW TW082101851A patent/TW286286B/zh active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2562800A1 (en) * | 1984-04-11 | 1985-10-18 | Fournier Laboratoires | Device for percutaneous administration of medicaments |
EP0429842A2 (en) * | 1989-10-27 | 1991-06-05 | Korea Research Institute Of Chemical Technology | Device for the transdermal administration of protein or peptide drug |
US5090963A (en) * | 1990-10-19 | 1992-02-25 | Product Development (Z.G.S.) Ltd. | Electrochemically driven metering medicament dispenser |
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US5997501A (en) * | 1993-11-18 | 1999-12-07 | Elan Corporation, Plc | Intradermal drug delivery device |
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US5858001A (en) * | 1995-12-11 | 1999-01-12 | Elan Medical Technologies Limited | Cartridge-based drug delivery device |
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US7404815B2 (en) | 2000-05-01 | 2008-07-29 | Lifescan, Inc. | Tissue ablation by shear force for sampling biological fluids and delivering active agents |
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Also Published As
Publication number | Publication date |
---|---|
TW286286B (en) | 1996-09-21 |
CA2131794A1 (en) | 1993-09-16 |
EP0630276A1 (en) | 1994-12-28 |
JPH07508427A (en) | 1995-09-21 |
DE69312916D1 (en) | 1997-09-11 |
ATE156375T1 (en) | 1997-08-15 |
US5279544A (en) | 1994-01-18 |
DE69312916T2 (en) | 1998-01-08 |
AU3632593A (en) | 1993-10-05 |
EP0630276B1 (en) | 1997-08-06 |
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