WO1993008749A1 - Method for reducing damage to and lesions of surfaces in the propagation field of high-energy pressure waves, using an agent for reducing bubble formation caused by the pressure waves, and pressure wave generating device for implementing said method - Google Patents
Method for reducing damage to and lesions of surfaces in the propagation field of high-energy pressure waves, using an agent for reducing bubble formation caused by the pressure waves, and pressure wave generating device for implementing said method Download PDFInfo
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- WO1993008749A1 WO1993008749A1 PCT/FR1992/001007 FR9201007W WO9308749A1 WO 1993008749 A1 WO1993008749 A1 WO 1993008749A1 FR 9201007 W FR9201007 W FR 9201007W WO 9308749 A1 WO9308749 A1 WO 9308749A1
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- Prior art keywords
- silicone oil
- pressure waves
- membrane
- interface
- living
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/225—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
- A61B17/2251—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves characterised by coupling elements between the apparatus, e.g. shock wave apparatus or locating means, and the patient, e.g. details of bags, pressure control of bag on patient
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/42—Details of probe positioning or probe attachment to the patient
- A61B8/4272—Details of probe positioning or probe attachment to the patient involving the acoustic interface between the transducer and the tissue
- A61B8/4281—Details of probe positioning or probe attachment to the patient involving the acoustic interface between the transducer and the tissue characterised by sound-transmitting media or devices for coupling the transducer to the tissue
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- G—PHYSICS
- G10—MUSICAL INSTRUMENTS; ACOUSTICS
- G10K—SOUND-PRODUCING DEVICES; METHODS OR DEVICES FOR PROTECTING AGAINST, OR FOR DAMPING, NOISE OR OTHER ACOUSTIC WAVES IN GENERAL; ACOUSTICS NOT OTHERWISE PROVIDED FOR
- G10K11/00—Methods or devices for transmitting, conducting or directing sound in general; Methods or devices for protecting against, or for damping, noise or other acoustic waves in general
- G10K11/02—Mechanical acoustic impedances; Impedance matching, e.g. by horns; Acoustic resonators
Definitions
- the present invention essentially relates to a process for reducing the phenomena of destruction or damage to surfaces located in the field of propagation of power pressure waves, by the use of an agent which reduces the formation of bubbles created by pressure waves, and apparatus for generating pressure waves with application.
- bubbles are generated by power pressure waves used to perform therapy. This is for example the case of pressure waves generated by shock waves such as those used in lithotripsy, as well as pressure waves generated by focused ultrasonic waves. These bubbles thus generated are then imploded by pressure waves subsequently emitted. All of these phenomena are often commonly referred to as cavitation phenomena.
- document EP-A-0226041 a method and a device for coupling a membrane to the skin of the human body by means of a bag filled with a gel which can be inserted or removed from the bag through longitudinal holes in the direction of a gel reserve.
- document EP-A-0229 241 cites the use of a gel between the body and the membrane, in combination with a device for removing air bubbles by mechanical means of the wiper type.
- the pressure waves are generated in a coupling liquid, this coupling liquid being in contact with the patient's skin, so that the accidental presence of air bubbles between the coupling and the patient's skin does not constitute a real problem, due in particular to the fact that they are evacuated naturally.
- the major problem lies in the creation of gas bubbles resulting from the cavitation phenomena inherent in the transmission of high power ultrasonic pressure waves, this cavitation phenomenon being nonexistent in ultrasonic diagnostic probes.
- the main object of the present invention is to solve the new technical problem consisting in providing a solution making it possible to reduce the phenomena of destruction or damage to surfaces located in the field of propagation of pressure waves of power, thereby making it possible to make more effective the use of focused pressure wave for therapeutic purposes, preferably by thermotherapy, in particular the use of focused power ultrasound; or focused shock waves such as in lithotripsy, treatment of tumors or bones.
- the main object of the present invention is also to solve the new technical problem consisting in providing a solution making it possible to increase the power of pressure waves, in particular ultrasonic pressure waves, without any significant phenomenon of bubble creation. by power pressure waves, unlike previous solutions.
- the object of the present invention is to solve these technical problems in a simple, inexpensive manner which can be used on an industrial scale, making it possible to carry out therapeutic treatments under excellent conditions of efficiency and safety for the patient.
- the present invention makes it possible for the first time to solve the above-mentioned technical problems in a simultaneous, simple, inexpensive manner and therefore usable on an industrial and medical scale.
- the present invention provides a method for reducing the phenomena of destruction or damage at the interface of two media, liquid or solid, in particular at the interface of a liquid medium and a fabric of a being living, especially a human being; or at the interface of a liquid medium and a solid medium, in particular a membrane, or even at the interface of a solid medium, in particular a membrane, and of a tissue of a living being, said interface being traversed by power pressure waves, characterized in that at least one of said interfaces is applied an agent reducing the destruction or damage to said interface.
- this agent reduces the formation of bubbles by cavitation.
- this agent reducing destruction or damage comprises a silicon oil.
- this silicone oil is essentially insoluble in water.
- this agent reducing destruction or damage is applied in the form of a substantially continuous coating on said interface where the phenomenon of cavitation is likely to occur, in particular on the area of the skin of a being. living, in particular a human being, crossed by pressure waves for the treatment of a target inside the body.
- This target can be a concretion, a tumor tissue or a bone to be treated.
- the agent reducing destruction or damage is applied in the form of a substantially continuous coating on the internal and external surfaces of a membrane containing a liquid used for coupling pressure waves, in particular focused, for the treatment of a target inside the body of a living being, in particular a human being.
- the aforementioned silicone oil is used in an essentially pure state.
- this oil has a viscosity of the order of 100 centipoise. It is possible, for example, to use a silicone oil in the pure state marketed by the Rhône-Poulenc company under the RH0D0RSIL Q> brand - type 47V and more particularly type 47V100.
- this agent for reducing destruction or damage comprises a silicone oil in the excipient state at a concentration of at least 50%.
- a product containing at least 50% of silicone oil is a cosmetic or pharmaceutical product, such as a moisturizing or sun cream. Such products are well known to those skilled in the art.
- the present invention also covers an apparatus for generating therapy pressure waves, comprising a device generating pressure waves, comprising a focusing cavity completely filled with a cou ⁇ liquid, characterized in that that it comprises means for coating or covering at least partially with a substantially continuous layer, at least the interface zone traversed by said pressure waves, of a tissue of a living being, such as the skin , in contact with the coupling liquid, with an agent which reduces destruction or damage.
- the present invention also covers an apparatus for generating pressure waves, comprising a device generating pressure waves having a cavity closed in a substantially sealed manner by a membrane, said cavity being completely filled with a liquid.
- this agent reducing destruction or damage comprises a silicone oil.
- this silicone oil is essentially insoluble in water.
- the oil The aforementioned silicone is used in an essentially pure state.
- this oil has a viscosity of the order of 100 ce ⁇ tipoises. It is possible, for example, to use a silicone oil in the pure state marketed by the company Rhône-Poulenc under the brand RHODORSIL, type 47V and more particularly type 47V100.
- the agent reducing destruction or damage comprises a silicone oil in the excipient state at a concentration of at least 50%, for example in the form of a cosmetic or pharmaceutical product, such than a moisturizer or sunscreen.
- the pressure wave generator device is a generator device of the ultrasonic type, in particular focused.
- This ultrasonic generator device can comprise at least one piezoelectric transducer element of spherical shape, achieving natural focusing or a piezoelectric transducer element of any shape focusing the pressure waves by electronic means.
- this device is an extracorporeal treatment device for a target inside the body of a living being, in particular a human being, such as a concretion, a benign or tumor tissue or a bone to be treated.
- the invention unexpectedly reduces the burning phenomena of the skin which receives the pressure waves transmitted by the coupling liquid, burning phenomena which are particularly traumatic for the patient and for which no satisfactory solution exists. 'was previously proposed. Also, the phenomena of destruction or damage to the coupling membrane are avoided or reduced. The elimination of the cavitation phenomenon is demonstrated by the following example given by way of illustration which does not therefore in no way limit the scope of the invention.
- FIG. 1 schematically represents a partial section of a pressure wave generating apparatus comprising a pressure wave generating device closed by a membrane, the internal surface and the external surface of which are here covered with a silicone oil , as will be explained in detail using the following example; and figure 2 represents a curve representing
- Curve 1 with the squares is obtained with the use of a liquid coupling medium such as degassed tap water without agent reducing the destruction or damage of the tissues of a living being in contact with the coupling liquid (comparative curve), while curve 2 connecting the points is obtained with the same coupling liquid, but the membrane has its internal and external faces coated or covered with a substantially continuous layer of an agent reducing the destruction or damage to tissues of a living being, for example the skin, here the essentially pure silicone oil constituted by the silicone oil available commercially this under the trade name RHODORSIL. ⁇ de Rhône-Poulenc, type 47V100.
- a pressure wave generating device represented by the general reference number 10.
- This pressure wave generating device more particularly comprises a pressure wave generating device referenced 12 comprising preferably at least one piezoelectric transducer element 14, here in the form of a spherical cap achieving natural focusing at a focal point F.
- This generator device 12 is also equipped with an elastic membrane 16 characterized by its acoustic transparency, such as a mem ⁇ brane made of latex or silicone.
- the cavity defined inside the membrane 16 and the spherical cap 14 is completely filled with a coupling liquid 18, such as advantageously dega ⁇ zed water, as is well known to those skilled in the art. 'art.
- the internal face 19 and the external face 20, at least on the zone intended to come into contact with the skin 22 of a patient P, are coated or covered with a substantially continuous layer of a agent 24 reducing the destruction or damage of the interface tissues in contact with the membrane here the skin 22 of the patient P as well as of the membrane with the coupling liquid, consisting of a silicone oil, for example available silicone oil commercially under the trade name RH0D0RSIL R from Rhône-Poulenc, type 47V100.
- a silicone oil for example available silicone oil commercially under the trade name RH0D0RSIL R from Rhône-Poulenc, type 47V100.
- pressure wave generating devices can be used for the extracorporeal treatment of concretions, tumors, bone areas, in particular fractures (osteotritis), the area to be treated being placed in coincidence with the focal area of the device generating focused pressure waves, it also delays the destruction or lesion of the membrane.
Abstract
A method for reducing damage and lesions at the interface between two solid or liquid media, particularly at the interface between a liquid medium and the tissue of a living being or a solid medium such as a membrane, or at the interface between a solid medium such as a membrane and the tissue of a living being, as well as an apparatus for implementing said method, are described. The apparatus includes a pressure wave generating device (12) provided with a membrane (16) defining a cavity which is completely filled with a coupling liquid (18). The inner (19) and outer (20) surfaces of the membrane (16) are coated with an agent (24) for reducing damage or lesions at said interface, said agent preferably consisting of a silicone oil. The method may be used in pressure wave generating apparatuses for performing extracorporeal treatments without causing damage or lesions, even when operating at maximum power.
Description
05 de génération d'ondes de pression en comportant application05 generating pressure waves with application
La présente invention concerne essentiellement un pro¬ cédé de réduction des phénomènes de destruction ou de lésion des surfaces se trouvant dans le champ de propagation d'ondes de pres- 10 sion de puissance, par l'emploi d'un agent diminuant la formation de bulles créées par les ondes de pression, et appareil de généra¬ tion d'ondes de pression en comportant application.The present invention essentially relates to a process for reducing the phenomena of destruction or damage to surfaces located in the field of propagation of power pressure waves, by the use of an agent which reduces the formation of bubbles created by pressure waves, and apparatus for generating pressure waves with application.
On sait que des bulles sont générées par des ondes de pression de puissance utilisées pour réaliser la thérapie. C'est 15 par exemple le cas des ondes de pression générées par des ondes de choc telles que celles utilisées en lithotritie, ainsi que les ondes de pression générées par des ondes ultrasoniques focalisées. Ces bulles ainsi générées se trouvent ensuite implosées par des ondes de pression ultérieurement émises. L'ensemble de ces phéno- 20 mènes est souvent communément dénommé phénomènes de cavitation.It is known that bubbles are generated by power pressure waves used to perform therapy. This is for example the case of pressure waves generated by shock waves such as those used in lithotripsy, as well as pressure waves generated by focused ultrasonic waves. These bubbles thus generated are then imploded by pressure waves subsequently emitted. All of these phenomena are often commonly referred to as cavitation phenomena.
Ce phénomène de génération de bulles de gaz conduit à des destructions ou lésions des surfaces se trouvant dans Le champ de propagation des ondes de pression, ce qui est inacceptable dans le cas d'une thérapie où de telles surfaces sont généralement consti- 25 tuées par la peau du patient. La création de bulles et leur implo¬ sion est d'autant plus forte que la pression est élevée. Or, il faut une pression élevée pour que l'onde de pression soit efficace et notamment pour induire une montée en température rapide des tissus pour atteindre un seuil d'efficacité lui-même dépendant de * 30 La pression. De ce fait, il y a lieu d'éviter le phénomène de généra-This phenomenon of generation of gas bubbles leads to destruction or damage to the surfaces located in the field of propagation of the pressure waves, which is unacceptable in the case of a therapy where such surfaces are generally formed by the patient's skin. The creation of bubbles and their implosion is all the stronger the higher the pressure. Now, a high pressure is necessary for the pressure wave to be effective and in particular to induce a rapid rise in temperature of the tissues to reach an efficiency threshold itself dependent on * 30 The pressure. Therefore, the phenomenon of genera-
*" tion de bulles sur les surfaces se trouvant dans le champ de propa¬ gation des ondes de pression et notamment des interfaces tissus- liquide de couplage lorsque l'on veut traiter en profondeur des 35 tissus par ondes de pression de puissance, comme par exemple Les
ondes de pression focalisées, que ce soit des ondes de choc ou des ondes ultrasoniques.* " tion of bubbles on the surfaces located in the field of propagation of the pressure waves and in particular of the tissue-liquid coupling interfaces when it is desired to treat in depth the tissues by power pressure waves, such as by example The focused pressure waves, whether shock waves or ultrasonic waves.
Il a déjà été proposé de limiter la présence des bulles de gaz en utilisant de l'eau de couplage dégazée par traitement sous vide, un recyclage étant réalisé en permanence (voir EP-A- 0 090 138).It has already been proposed to limit the presence of gas bubbles by using degassed coupling water by vacuum treatment, recycling being carried out continuously (see EP-A-0 090 138).
D'autre part, il a également été proposé par le document EP-A-0226041 un procédé et un dispositif pour le couplage d'une membrane à la peau du corps humain par l'intermédiaire d'une poche remplie d'un gel qui peut être inséré ou évacué de la poche par l'intermédiaire d'orifices longitudinaux en direction d'une réserve de gel. De même, le document EP-A-0229 241 cite l'emploi d'un gel entre le corps et la membrane, en combinaison avec un dispositif d'enlèvement des bulles d'air par voie mécanique de type essuie- glace.On the other hand, it has also been proposed by document EP-A-0226041 a method and a device for coupling a membrane to the skin of the human body by means of a bag filled with a gel which can be inserted or removed from the bag through longitudinal holes in the direction of a gel reserve. Likewise, document EP-A-0229 241 cites the use of a gel between the body and the membrane, in combination with a device for removing air bubbles by mechanical means of the wiper type.
Or, il apparaît que l'emploi d'un gel ne permet pas d'éliminer de manière efficace les phénomènes de cavitation et que cette solution n'est pas utilisable en pratique, en particulier dans le cadre de traitement par thermothêrapie où les ondes de pression sont de durée relativement longue, c'est-à-dire d'une durée supérieure à la microseconde.However, it appears that the use of a gel does not make it possible to effectively eliminate cavitation phenomena and that this solution cannot be used in practice, in particular in the context of treatment by thermotherapy where the waves of pressures are of relatively long duration, that is to say of a duration greater than the microsecond.
Encore, il est connu par le document US-A-4886 068 KANEK0 un agent de couplage ultrasonique de faible viscosité uti¬ lisant une huile à base de silicone qui est essentiellement soluble dans la solution aqueuse, dans le but d'éviter l'emprison¬ nement de bulles d'air entre la surface de la sonde et la peau du patient, alors que la sonde de diagnostic est dans l'air.Again, it is known from document US-A-4886 068 KANEK0 an ultrasonic coupling agent of low viscosity using a silicone-based oil which is essentially soluble in the aqueous solution, in order to avoid imprisonment ¬ ment of air bubbles between the surface of the probe and the patient's skin, while the diagnostic probe is in the air.
Or, dans le cadre du traitement par thermothérapie, les ondes de pression sont générées dans un liquide de couplage, ce liquide de couplage étant en contact avec la peau du patient, de sorte que la présence accidentelle de bulles d'air entre le liquide de couplage et la peau du patient ne constitue par un réel problème, en raison notamment du fait qu'elles s'évacuent naturel¬ lement. Mais le problème majeur réside dans la création de bulles de gaz résultant des phénomènes de cavitation inhérents à la trans¬ mission d'ondes de pression ultrasoniques de puissance élevée, ce
phénomène de cavitation étant inexistant dans les sondes ultraso¬ niques de diagnostic.However, in the context of thermotherapy treatment, the pressure waves are generated in a coupling liquid, this coupling liquid being in contact with the patient's skin, so that the accidental presence of air bubbles between the coupling and the patient's skin does not constitute a real problem, due in particular to the fact that they are evacuated naturally. However, the major problem lies in the creation of gas bubbles resulting from the cavitation phenomena inherent in the transmission of high power ultrasonic pressure waves, this cavitation phenomenon being nonexistent in ultrasonic diagnostic probes.
Ce phénomène de cavitation est particulèrement aggravé dans le cadre de traitement par thermothérapie où les ondes de pression sont de durée relativement longue, c'est-à-dire d'une durée supérieure à la microseconde.This cavitation phenomenon is particularly aggravated in the context of thermotherapy treatment where the pressure waves are of relatively long duration, that is to say of a duration greater than the microsecond.
En conséquence, la présente invention a pour but princi¬ pal de résoudre le nouveau problème technique consistant en la fourniture d'une solution permettant de réduire les phénomènes de destructions ou de lésions des surfaces se trouvant dans le champ de propagation des ondes de pression de puissance, en permettant ainsi de rendre plus efficace l'utilisation d'onde de pression focalisée à but thérapeutique, de préférence par thermothérapie, en particulier l'emploi d'ultrasons focalisés de puissance ; ou des ondes de choc focalisées comme dans le cadre de la lithotritie, traitement des tumeurs ou des os.Consequently, the main object of the present invention is to solve the new technical problem consisting in providing a solution making it possible to reduce the phenomena of destruction or damage to surfaces located in the field of propagation of pressure waves of power, thereby making it possible to make more effective the use of focused pressure wave for therapeutic purposes, preferably by thermotherapy, in particular the use of focused power ultrasound; or focused shock waves such as in lithotripsy, treatment of tumors or bones.
La présente invention a encore pour but principal de résoudre le nouveau problème technique consistant en la fourniture d'une solution permettant d'augmenter la puissance d'ondes de pression, en particulier d'ondes de pression ultrasoniques, sans phénomène sensible de création de bulles par ondes de pression de puissance, contrairement aux solutions antérieures.The main object of the present invention is also to solve the new technical problem consisting in providing a solution making it possible to increase the power of pressure waves, in particular ultrasonic pressure waves, without any significant phenomenon of bubble creation. by power pressure waves, unlike previous solutions.
La présente invention a pour but de résoudre ces pro¬ blèmes techniques d'une manière simple, peu coûteuse, utilisable à l'échelle industrielle, permettant de réaliser des traitements thérapeutiques dans d'excellentes conditions d'efficacité et de sécurité pour le patient.The object of the present invention is to solve these technical problems in a simple, inexpensive manner which can be used on an industrial scale, making it possible to carry out therapeutic treatments under excellent conditions of efficiency and safety for the patient.
La présente invention permet pour la première fois de résoudre les problèmes techniques ci-dessus énoncés d'une manière simultanée, simple, peu coûteuse et donc utilisable à l'échelle industrielle et médicale.The present invention makes it possible for the first time to solve the above-mentioned technical problems in a simultaneous, simple, inexpensive manner and therefore usable on an industrial and medical scale.
Ainsi, selon un premier aspect, la présente invention fournit un procédé de réduction des phénomènes de destructions ou lésions à l'interface de deux milieux, liquide ou solide, en parti- culier à l'interface d'un milieu liquide et d'un tissu d'un être
vivant, en particulier un être humain ; ou à l'interface d'un milieu liquide et d'un milieu solide, en particulier une membrane, voire encore à l'interface d'un milieu solide, en particulier une membrane, et d'un tissu d'un être vivant, ladite interface étant traversée par des ondes de pression de puissance, caractérisé en ce qu'on applique au moins à l'une desdites interfaces un agent diminuant les destructions ou lésions à ladite interface. De préfé¬ rence, cet agent diminue la formation de bulles par cavitation.Thus, according to a first aspect, the present invention provides a method for reducing the phenomena of destruction or damage at the interface of two media, liquid or solid, in particular at the interface of a liquid medium and a fabric of a being living, especially a human being; or at the interface of a liquid medium and a solid medium, in particular a membrane, or even at the interface of a solid medium, in particular a membrane, and of a tissue of a living being, said interface being traversed by power pressure waves, characterized in that at least one of said interfaces is applied an agent reducing the destruction or damage to said interface. Preferably, this agent reduces the formation of bubbles by cavitation.
Selon un mode de réalisation avantageux, cet agent dimi- nuant les destructions ou lésions comprend une huile silicoπe. Avantageusement, cette huile silicone est essentiellement insoluble dans l'eau.According to an advantageous embodiment, this agent reducing destruction or damage comprises a silicon oil. Advantageously, this silicone oil is essentially insoluble in water.
Selon un autre mode de réalisation avantageux, cet agent réduisant les destructions ou lésions est appliqué sous forme de revêtement sensiblement continu sur ladite interface où le phéno¬ mène de cavitation risque de se produire, en particulier sur la zone de la peau d'un être vivant, en particulier un être humain, traversée par des ondes de pression pour le traitement d'une cible à l'intérieur du corps. Cette cible peut être une concrétion, un tissu tumoral ou un os à traiter.According to another advantageous embodiment, this agent reducing destruction or damage is applied in the form of a substantially continuous coating on said interface where the phenomenon of cavitation is likely to occur, in particular on the area of the skin of a being. living, in particular a human being, crossed by pressure waves for the treatment of a target inside the body. This target can be a concretion, a tumor tissue or a bone to be treated.
Selon un autre mode de réalisation avantageux, l'agent réduisant les destructions ou lésions est appliqué sous forme d'un revêtement sensiblement continu sur les surfaces interne et externe d'une membrane renfermant un liquide servant au couplage d'ondes de pression, en particulier focalisées, pour le traitement d'une cible à l'intérieur du corps d'un être vivant, en particu¬ lier un être humain.According to another advantageous embodiment, the agent reducing destruction or damage is applied in the form of a substantially continuous coating on the internal and external surfaces of a membrane containing a liquid used for coupling pressure waves, in particular focused, for the treatment of a target inside the body of a living being, in particular a human being.
Selon une autre caractéristique avantageuse, l'huile silicone précitée est utilisée à l'état essentiellement pur. On préfère utiliser une huile silicone présentant une très faibleAccording to another advantageous characteristic, the aforementioned silicone oil is used in an essentially pure state. We prefer to use a silicone oil with a very low
_2 tension de vapeur, typiquement de l'ordre de 10 millibars à o_2 vapor pressure, typically around 10 millibars at o
200 C et/ou qui présente une faible tension superficielle typiquement de 20 millinewtons par mètre, et/ou une compressibilite élevée. On préfère que cette huile présente une viscosité de l'ordre de 100 centipoises. On peut par exemple utiliser une huile silicone à l'état pur commercialisée par la
société Rhône-Poulenc sous la marque RH0D0RSIL Q>- type 47V et plus particulièrement type 47V100.200 C and / or which has a low surface tension, typically 20 millinewtons per meter, and / or a high compressibility. It is preferred that this oil has a viscosity of the order of 100 centipoise. It is possible, for example, to use a silicone oil in the pure state marketed by the Rhône-Poulenc company under the RH0D0RSIL Q> brand - type 47V and more particularly type 47V100.
Selon un autre mode de réalisation particulier, cet agent de réduction des destructions ou lésions comprend une huile sili- cône a l'état d'excipient a une concentration d'au moins 50%. Avan¬ tageusement, un produit contenant au moins 50% d'huile silicone est un produit cosmétique ou pharmaceutique, tel qu'une crème hydra¬ tante ou solaire. De tels produits sont bien connus a l'homme de l'art. Selon un deuxième aspect, la présente invention couvre encore un appareil de génération d'ondes de pression de thérapie, comprenant un dispositif générateur d'ondes de pression, comprenant une cavité focalisante remplie complètement d'un liquide de cou¬ plage, caractérisé en ce qu'il comprend des moyens pour enduire ou recouvrir au moins partiellement d'une couche sensiblement con¬ tinue, au moins la zone d'interface traversée par lesdites ondes de pression, d'un tissu d'un être vivant, tel que la peau, en contact avec le liquide de couplage, avec un agent diminuant les destruc¬ tions ou lésions. Selon un troisième aspect, la présente invention couvre encore un appareil de génération d'ondes de pression, comprenant un dispositif générateur d'ondes de pression ayant une cavité fermée de manière essentiellement étanche par une membrane, ladite cavité étant remplie complètement d'un liquide de couplage, caractérisé en ce que la surface externe et/ou la surface interne de ladite membrane est enduite ou recouverte au moins partiellement d'une couche sensiblement continue d'un agent diminuant les. destructions ou lésions d'un tissu d'un être vivant en contact avec la membrane et/ou de la membrane, avec un agent diminuant les destructions ou lésions, au moins sur la zone traversée par lesdites ondes de pres¬ sion.According to another particular embodiment, this agent for reducing destruction or damage comprises a silicone oil in the excipient state at a concentration of at least 50%. Advantageously, a product containing at least 50% of silicone oil is a cosmetic or pharmaceutical product, such as a moisturizing or sun cream. Such products are well known to those skilled in the art. According to a second aspect, the present invention also covers an apparatus for generating therapy pressure waves, comprising a device generating pressure waves, comprising a focusing cavity completely filled with a cou¬ liquid, characterized in that that it comprises means for coating or covering at least partially with a substantially continuous layer, at least the interface zone traversed by said pressure waves, of a tissue of a living being, such as the skin , in contact with the coupling liquid, with an agent which reduces destruction or damage. According to a third aspect, the present invention also covers an apparatus for generating pressure waves, comprising a device generating pressure waves having a cavity closed in a substantially sealed manner by a membrane, said cavity being completely filled with a liquid. coupling, characterized in that the external surface and / or the internal surface of said membrane is coated or covered at least partially with a substantially continuous layer of a reducing agent. destruction or damage of a tissue of a living being in contact with the membrane and / or of the membrane, with an agent reducing the destruction or damage, at least in the area traversed by said pressure waves.
Selon un mode de réalisation préféré, cet agent diminuant les destructions ou lésions comprend une huile silicone De préfé¬ rence, cette huile silicone est essentiellement insoluble dans l'eau.According to a preferred embodiment, this agent reducing destruction or damage comprises a silicone oil. Preferably, this silicone oil is essentially insoluble in water.
Selon une autre caractéristique avantageuse, l'huile
silicone précitée est utilisée à l'état essentiellement pur. On préfère utiliser une huile silicone présentant une très faibleAccording to another advantageous characteristic, the oil The aforementioned silicone is used in an essentially pure state. We prefer to use a silicone oil with a very low
-2 tension de vapeur, typiquement de l'ordre de 10 millibars a o-2 vapor pressure, typically of the order of 10 millibars a o
200 C et/ou qui présente une faible tension superficielle typiquement de 20 milline tons par mètre, et/ou une compressibilite élevée. On préfère que cette huile présente une viscosité de l'ordre de 100 ceπtipoises. On peut par exemple utiliser une huile silicone à l'état pur commercialisée par la société Rhône-Poulenc sous la marque RHODORSIL , type 47V et plus particulièrement type 47V100.200 C and / or which has a low surface tension, typically 20 milline tons per meter, and / or a high compressibility. It is preferred that this oil has a viscosity of the order of 100 ceπtipoises. It is possible, for example, to use a silicone oil in the pure state marketed by the company Rhône-Poulenc under the brand RHODORSIL, type 47V and more particularly type 47V100.
Selon un autre mode de réalisation particulier, l'agent diminuant les destructions ou lésions comprend une huile silicone à l'état d'excipient à une concentration d'au moins 50%, par exemple sous forme d'un produit cosmétique ou pharmaceutique, tel qu'un crème hydratante ou solaire.According to another particular embodiment, the agent reducing destruction or damage comprises a silicone oil in the excipient state at a concentration of at least 50%, for example in the form of a cosmetic or pharmaceutical product, such than a moisturizer or sunscreen.
Selon un mode de réalisation particulier, le dispositif générateur d'ondes de pression est un dispositif générateur de type ultrasoπique, en particulier focalisé. Ce dispositif générateur ultrasonique peut comprendre au moins un élément transducteur piézo-électrique de forme sphêrique, réalisant une focalisation naturelle ou un élément transducteur piézo-électrique de forme quelconque focalisant les ondes de pression par des moyens électro¬ niques.According to a particular embodiment, the pressure wave generator device is a generator device of the ultrasonic type, in particular focused. This ultrasonic generator device can comprise at least one piezoelectric transducer element of spherical shape, achieving natural focusing or a piezoelectric transducer element of any shape focusing the pressure waves by electronic means.
De préférence, cet appareil est un appareil de traitement extracorporel d'une cible à l'intérieur du corps d'un être vivant, en particulier un être humain, telle qu'une concrétion, un tissu bénin ou tumoral ou un os à traiter.Preferably, this device is an extracorporeal treatment device for a target inside the body of a living being, in particular a human being, such as a concretion, a benign or tumor tissue or a bone to be treated.
Grâce à l'invention, on réduit de manière inattendue les phénomènes de brûlure de la peau qui reçoit les ondes de pression transmises par le liquide de couplage, phénomènes de brûlure qui sont particulièrement traumatisants pour le patient et pour les¬ quels aucune solution satisfaisante n'avait été proposée antérieu¬ rement. Egalement, on évite ou diminue les phénomènes de destruc¬ tions ou de lésions de la membrane de couplage. L'élimination du phénomène de cavitation est mise en évidence par l'exemple suivant donné à titre illustratif qui ne
saurait donc en aucune façon limiter la portée de l'invention.Thanks to the invention, unexpectedly reduces the burning phenomena of the skin which receives the pressure waves transmitted by the coupling liquid, burning phenomena which are particularly traumatic for the patient and for which no satisfactory solution exists. 'was previously proposed. Also, the phenomena of destruction or damage to the coupling membrane are avoided or reduced. The elimination of the cavitation phenomenon is demonstrated by the following example given by way of illustration which does not therefore in no way limit the scope of the invention.
Dans les dessins :In the drawings:
La figure 1 représente schématiquement une coupe par¬ tielle d'un appareil de génération d'ondes de pression comprenant un dispositif générateur d'ondes de pression fermé par une membrane dont la surface interne et la surface externe sont ici recouvertes d'une huile silicone, comme cela sera expliqué en détail à l'aide de l'exemple suivant ; et la figure 2 représente une courbe représentantFIG. 1 schematically represents a partial section of a pressure wave generating apparatus comprising a pressure wave generating device closed by a membrane, the internal surface and the external surface of which are here covered with a silicone oil , as will be explained in detail using the following example; and figure 2 represents a curve representing
2 l'intensité du champ de pression en /cm en ordonnée en fonction de l'intensité électrique envoyée à l'élément transducteur piézo¬ électrique de forme spherique définissant un centre géométrique ou point focal F, auquel sont focalisées les ondes ultrasonores émises, du dispositif objet de la figure 1. La courbe 1 avec les carrés est obtenue avec l'emploi d'un milieu liquide de couplage tel que de l'eau dégazée du robinet sans agent diminuant les destructions ou lésions des tissus d'un être vivant en contact avec le liquide de couplage (courbe comparative) , tandis que la courbe 2 reliant les points est obtenue avec le même liquide de couplage, mais la membrane a ses faces intérieure et extérieure enduites ou recouvertes d'une couche sensiblement continue d'un agent diminuant les destructions ou lésions de tissus d'un être vivant, par exemple la peau, ici l'huile silicone à l'état essentiellement pur constituée par l'huile silicone disponible dans le commerce sous le nom commercial RHODORSIL.^ de Rhône-Poulenc, type 47V100.2 the intensity of the pressure field in / cm on the y-axis as a function of the electric intensity sent to the piezoelectric transducer element of spherical shape defining a geometric center or focal point F, to which the emitted ultrasonic waves are focused, from device object of FIG. 1. Curve 1 with the squares is obtained with the use of a liquid coupling medium such as degassed tap water without agent reducing the destruction or damage of the tissues of a living being in contact with the coupling liquid (comparative curve), while curve 2 connecting the points is obtained with the same coupling liquid, but the membrane has its internal and external faces coated or covered with a substantially continuous layer of an agent reducing the destruction or damage to tissues of a living being, for example the skin, here the essentially pure silicone oil constituted by the silicone oil available commercially this under the trade name RHODORSIL. ^ de Rhône-Poulenc, type 47V100.
Cette courbe est explicitée plus en détail en référence à l'exemple suivant.This curve is explained in more detail with reference to the following example.
ExempleExample
A la figure 1, on a représenté un appareil de génération d'ondes de pression représenté par le numéro de référence général 10. Cet appareil générateur d'ondes de pression comprend plus particulièrement un dispositif générateur d'ondes de pression réfé- rencé 12 comprenant de préférence au moins un élément transduc¬ teur piézo-électrique 14, ici sous forme de calotte spherique
réalisant une focalisation naturelle en un point focal F. Ce dispo¬ sitif générateur 12 est également équipé d'une membrane élastique 16 caractérisée par sa transparence acoustique, telle qu'une mem¬ brane en latex ou silicone. La cavité définie à l'intérieur de la membrane 16 et de la calotte spherique 14 est remplie complètement d'un liquide de couplage 18, tel que de l'eau avantageusement déga¬ zée, comme cela est bien connu à l'homme de l'art.In Figure 1, there is shown a pressure wave generating device represented by the general reference number 10. This pressure wave generating device more particularly comprises a pressure wave generating device referenced 12 comprising preferably at least one piezoelectric transducer element 14, here in the form of a spherical cap achieving natural focusing at a focal point F. This generator device 12 is also equipped with an elastic membrane 16 characterized by its acoustic transparency, such as a mem¬ brane made of latex or silicone. The cavity defined inside the membrane 16 and the spherical cap 14 is completely filled with a coupling liquid 18, such as advantageously dega¬ zed water, as is well known to those skilled in the art. 'art.
Selon l'invention, la face intérieure 19 et la face ex¬ térieure 20, au moins sur la zone destinée à venir en contact avec la peau 22 d'un patient P, sont enduites ou recouvertes d'une couche sensiblement continue d'un agent 24 diminuant les destruc¬ tions ou lésions des tissus d'interface en contact avec la membrane ici la peau 22 du patient P ainsi que de la membrane avec le liquide de couplage, constitué par une huile silicone, par exemple l'huile silicone disponible dans le commerce sous le nom commercial RH0D0RSILR de Rhône-Poulenc, type 47V100.According to the invention, the internal face 19 and the external face 20, at least on the zone intended to come into contact with the skin 22 of a patient P, are coated or covered with a substantially continuous layer of a agent 24 reducing the destruction or damage of the interface tissues in contact with the membrane here the skin 22 of the patient P as well as of the membrane with the coupling liquid, consisting of a silicone oil, for example available silicone oil commercially under the trade name RH0D0RSIL R from Rhône-Poulenc, type 47V100.
Avec un tel dispositif, on envoie une intensité élec¬ trique progressive à l'élément transducteur 14 et on mesure la pression des ondes de pression à la zone focale F. Cette expérience est réalisée tout d'abord sans enduire les surfaces interne ou externe de la membrane 16, pour servir de comparaison et les résultats obtenus sont rapportés à la figure 2 à la courbe 1.With such a device, a progressive electric intensity is sent to the transducer element 14 and the pressure wave pressure is measured at the focal zone F. This experiment is carried out first of all without coating the internal or external surfaces of the membrane 16, to serve as a comparison and the results obtained are reported in FIG. 2 in curve 1.
Les courbes de la figure 2 donnent en ordonnée l'inten-The curves in Figure 2 give the ordinate the intensity
2 site au point focal exprimée en /cm en fonction de la tension d'alimentation de l'élément transducteur 16, cette tension étant mise au carré pour obtenir une proportionnalité directe avec l'in-2 site at the focal point expressed in / cm as a function of the supply voltage of the transducer element 16, this voltage being squared to obtain direct proportionality with the
2 tensite, exprimée en mV .2 tensite, expressed in mV.
D'autre part, on réalise l'expérience avec le dispositif selon l'invention tel que représenté à la figure 1 et comportant une couche interne et externe d'huile silicone sur la membrane et l'on obtient la courbe 2 à la figure 2.On the other hand, the experiment is carried out with the device according to the invention as shown in FIG. 1 and comprising an internal and external layer of silicone oil on the membrane and the curve 2 in FIG. 2 is obtained. .
On peut ainsi constater que le champ de pression tra¬ versant la membrane revêtue d'huile silicone (courbe 2 selon l'in- vention) est supérieur à celui traversant la membrane non traitée (courbe 1, art antérieur) . En outre avec la membrane enduite
d'huile silicone, la pression recueillie reste beaucoup plus longtemps approximativement linéaire en fonction de l'intensité électrique envoyée à l'élément transducteur indiquant ainsi l'ab¬ sence de cavitation pour de plus fortes pressions, tandis que, dans le cas d'une membrane non enduite d'un agent selon l'invention (courbe 1, art antérieur), on observe un effet non linéaire très tôt résultant d'un phénomène de cavitation.It can thus be seen that the pressure field passing through the membrane coated with silicone oil (curve 2 according to the invention) is greater than that crossing the untreated membrane (curve 1, prior art). Also with the coated membrane of silicone oil, the pressure collected remains approximately linearly much longer as a function of the electrical intensity sent to the transducer element, thus indicating the absence of cavitation for higher pressures, while, in the case of a membrane not coated with an agent according to the invention (curve 1, prior art), a non-linear effect is observed very early resulting from a phenomenon of cavitation.
Lors d'essais in vivo, on a pu ainsi constater que, en l'absence de l'emploi d'une huile silicone sur la face interne et/ou externe de la membrane, on obtient des brûlures sur la peau du patient, tandis que, avec l'emploi d'une huile silicone conformé¬ ment à l'invention, aucun phénomène de brûlure de la peau du patient n'a pu être observé, ce qui constitue un résultat particu¬ lièrement inattendu. On comprend ainsi que l'invention permet de résoudre les problèmes techniques précédemment énoncés et de diminuer de manière significative les phénomènes de destructions ou de lésions des tissus en contact avec le liquide de couplage ou avec une membrane interposée entre la peau du patient et le liquide de couplage, ce qui permet en outre d'utiliser des ondes de pression de plus forte puissance, en particulier des ondes ultrasonores focalisées de plus forte puissance. Ceci permet de réaliser de manière efficace un traitement par voie extracorporelle dans le cas de traitement thérapeutique. On sait que les appareils de génération d'ondes de pression peuvent être utilisés pour le traitement extracorporel de concrétions, de tumeurs, de zones osseuses, en particulier les fractures (ostéotritie) , la zone à traiter étant mise en coïncidence avec la zone focale du dispositif générateur d'ondes de pression focalisées, on retarde aussi la destruction ou lésion de la membrane.During in vivo tests, it has thus been found that, in the absence of the use of a silicone oil on the internal and / or external face of the membrane, burns are obtained on the patient's skin, while that, with the use of a silicone oil in accordance with the invention, no phenomenon of burning of the patient's skin could be observed, which constitutes a particularly unexpected result. It is thus understood that the invention makes it possible to solve the technical problems previously stated and to significantly reduce the phenomena of destruction or damage to the tissues in contact with the coupling liquid or with a membrane interposed between the patient's skin and the liquid. coupling, which also makes it possible to use higher power pressure waves, in particular higher power focused ultrasonic waves. This makes it possible to effectively carry out an extracorporeal treatment in the case of therapeutic treatment. It is known that pressure wave generating devices can be used for the extracorporeal treatment of concretions, tumors, bone areas, in particular fractures (osteotritis), the area to be treated being placed in coincidence with the focal area of the device generating focused pressure waves, it also delays the destruction or lesion of the membrane.
Naturellement, l'invention comprend tous les moyens cons¬ tituant des équivalents techniques des moyens décrits ainsi que leurs diverses combinaisons.
Naturally, the invention includes all the means constituting technical equivalents of the means described as well as their various combinations.
Claims
1. Procédé de réduction des phénomènes de destructions ou de lésions à l'interface de deux milieux, liquide ou solide, en particulier à l'interface d'un milieu liquide et d'un tissu d'un être vivant, en particulier un être humain ; ou à l'interface d'un milieu liquide et d'un milieu solide, en particulier une membrane, voire encore à l'interface d'un milieu solide, en particulier une membrane et d'un tissu d'un être vivant, ladite interface étant traversée par des ondes de pression de puissance, caractérisé en ce qu'on applique au moins à l'une desdites interfaces un agent diminuant les destructions ou lésions à ladite interface.1. Method for reducing the phenomena of destruction or damage at the interface of two media, liquid or solid, in particular at the interface of a liquid medium and a tissue of a living being, in particular a being human ; or at the interface of a liquid medium and a solid medium, in particular a membrane, or even at the interface of a solid medium, in particular a membrane and of a tissue of a living being, said interface being traversed by power pressure waves, characterized in that at least one of said interfaces is applied an agent reducing the destruction or damage to said interface.
2. Procédé selon la revendication 1, caractérisé en ce que l'agent précité comprend une huile silicone, en particulier une huile silicone insoluble dans l'eau.2. Method according to claim 1, characterized in that the aforementioned agent comprises a silicone oil, in particular a silicone oil insoluble in water.
3. Procédé selon la revendication 2, caractérisé en que l'huile silicone présente une très faible tension de vapeur,3. Method according to claim 2, characterized in that the silicone oil has a very low vapor pressure,
-2 ° typiquement de l'ordre de 10 millibars à 200 C, et/ou une faible tension superficielle typiquement de 20 millinewtoπs par mètre, et/ou une compressibilite élevée, et/ou une viscosité de l'ordre de-2 ° typically of the order of 10 millibars at 200 ° C., and / or a low surface tension typically of 20 millinewtoπs per meter, and / or a high compressibility, and / or a viscosity of the order of
100 centipoises.100 centipoises.
4. Procédé selon la revendication 2, caractérisé en ce que l'agent précité comprend au moins 50% d'huile silicone, par exemple comprend un produit cosmétique ou pharmaceutique contenant au moins 50% d'huile silicone, par exemple une crème hydratante ou solaire.4. Method according to claim 2, characterized in that the aforementioned agent comprises at least 50% of silicone oil, for example comprises a cosmetic or pharmaceutical product containing at least 50% of silicone oil, for example a moisturizer or solar.
5. Procédé selon l'une des revendications précédentes, caractérisé en ce que l'agent précité est déposé sur la face interne et/ou externe d'une membrane enfermant un liquide de couplage d'ondes de pression acoustique.5. Method according to one of the preceding claims, characterized in that the aforementioned agent is deposited on the internal and / or external face of a membrane enclosing a coupling liquid of acoustic pressure waves.
6. Procédé selon la revendication 5, caractérisé en ce que la membrane est montée sur un dispositif de génération d'ondes de pression, en particulier focalisé, pour le traitement d'une cible à l'intérieur du corps d'un être vivant, en particulier d'un être humain, telle qu'une concrétion, un tissu tumoral ou un os à traiter. 6. Method according to claim 5, characterized in that the membrane is mounted on a device for generating pressure waves, in particular focused, for the treatment of a target inside the body of a living being, in particular of a human being, such as a concretion, a tumor tissue or a bone to be treated.
7. Appareil de génération d'ondes de pression de théra¬ pie, comprenant un dispositif générateur d'ondes de pression de thérapie, un liquide de couplage réalisant le couplage desdites ondes de pression de thérapie, avec un tissu d'un être vivant, en particulier un être humain, caractérisé en ce qu'il comprend des moyens pour enduire ou recouvrir au moins partiellement d'une couche sensiblement continue, au moins la zone d'interface tra¬ versée par lesdites ondes de pression de thérapie, avec un agent diminuant les destructions ou lésions. 7. Therapy pressure wave generation apparatus, comprising a therapy pressure wave generating device, a coupling liquid coupling said therapy pressure waves, with a tissue of a living being, in particular a human being, characterized in that it comprises means for coating or covering at least partially with a substantially continuous layer, at least the interface zone traversed by said therapy pressure waves, with an agent reducing destruction or damage.
8. Appareil selon la revendication 7, caractérisé en ce qu'il comprend une membrane transparente aux ondes de pression, interposée entre le liquide de couplage et le tissu, les moyens précités pour enduire ou recouvrir étant aussi utilisés pour enduire ou recouvrir la surface interne et/ou externe de ladite membrane.8. Apparatus according to claim 7, characterized in that it comprises a membrane transparent to pressure waves, interposed between the coupling liquid and the fabric, the aforementioned means for coating or covering also being used for coating or covering the internal surface and / or external of said membrane.
9. Appareil selon la revendication 7 ou 8, caractérisé en ce que l'agent précité comprend une huile silicone, en particu¬ lier une huile silicone insoluble dans l'eau.9. Apparatus according to claim 7 or 8, characterized in that the aforementioned agent comprises a silicone oil, in particu¬ bind a silicone oil insoluble in water.
10. Appareil selon la revendication 9, caractérisé en ce que l'agent précité est constitué d'une huile silicone présentant une très faible tension de vapeur, typiquement de10. Apparatus according to claim 9, characterized in that the aforementioned agent consists of a silicone oil having a very low vapor pressure, typically of
-2 ° l'ordre de 10 millibars à 200 C, et/ou une faible tension typique de 20 millinewtons par mètre, et une compressibilite élevée, et/ou une viscosité de l'ordre de 100 centipoises. -2 ° the order of 10 millibars at 200 C, and / or a typical low tension of 20 millinewtons per meter, and a high compressibility, and / or a viscosity of the order of 100 centipoise.
11. Appareil selon la revendication 8 ou 9, caractérisé en ce que l'agent précité comprend au moins 50% d'huile silicone, en particulier comprend un produit cosmétique ou pharmaceutique contenant au moins 50% d'huile silicone, tel qu'une crème hydratante ou solaire. 11. Apparatus according to claim 8 or 9, characterized in that the aforementioned agent comprises at least 50% silicone oil, in particular comprises a cosmetic or pharmaceutical product containing at least 50% silicone oil, such as a moisturizer or sunscreen.
12. Appareil selon l'une des revendications 7 à 11, caractérisé en ce que le dispositif générateur d'ondes de pression est un dispositif générateur de type ultrasonique, en particulier focalisé, par exemple en présentant une forme de calotte spherique. 12. Apparatus according to one of claims 7 to 11, characterized in that the pressure wave generator device is a generator device of the ultrasonic type, in particular focused, for example by having a spherical cap shape.
13. Appareil selon l'une des revendications 7 à 12, caractérisé en ce qu'il s'agit d'un appareil de traitement extra- corporel d'une cible à l'intérieur du corps d'un être vivant, en particulier un être humain, telle qu'une concrétion, un tissu •cumo- rai ou un os à traiter. 13. Apparatus according to one of claims 7 to 12, characterized in that it is an extracorporeal treatment apparatus of a target inside the body of a living being, in particular a human being, such as a concretion, a fabric • cumo- rai or bone to treat.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP92924746A EP0610434A1 (en) | 1991-10-31 | 1992-10-28 | Method for reducing damage to and lesions of surfaces in the propagation field of high-energy pressure waves, using an agent for reducing bubble formation caused by the pressure waves, and pressure wave generating device for implementing said method |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR91/13520 | 1991-10-31 | ||
| FR9113520 | 1991-10-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1993008749A1 true WO1993008749A1 (en) | 1993-05-13 |
Family
ID=9418549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/FR1992/001007 WO1993008749A1 (en) | 1991-10-31 | 1992-10-28 | Method for reducing damage to and lesions of surfaces in the propagation field of high-energy pressure waves, using an agent for reducing bubble formation caused by the pressure waves, and pressure wave generating device for implementing said method |
Country Status (2)
| Country | Link |
|---|---|
| EP (1) | EP0610434A1 (en) |
| WO (1) | WO1993008749A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997010758A1 (en) * | 1995-09-20 | 1997-03-27 | Storz Medical Ag | Device for treating body tissue and crushing calculi |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0090138A2 (en) * | 1982-03-25 | 1983-10-05 | DORNIER SYSTEM GmbH | Apparatus for the disintegration of concretions in living bodies |
| DE3817094A1 (en) * | 1988-04-18 | 1989-11-30 | Schubert Werner | Coupling and adhesive device for shock wave treatment units |
| US4886068A (en) * | 1985-07-29 | 1989-12-12 | Kabushiki Kaisha Toshiba | Ultrasonic coupling agent |
-
1992
- 1992-10-28 EP EP92924746A patent/EP0610434A1/en not_active Withdrawn
- 1992-10-28 WO PCT/FR1992/001007 patent/WO1993008749A1/en not_active Application Discontinuation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0090138A2 (en) * | 1982-03-25 | 1983-10-05 | DORNIER SYSTEM GmbH | Apparatus for the disintegration of concretions in living bodies |
| US4886068A (en) * | 1985-07-29 | 1989-12-12 | Kabushiki Kaisha Toshiba | Ultrasonic coupling agent |
| DE3817094A1 (en) * | 1988-04-18 | 1989-11-30 | Schubert Werner | Coupling and adhesive device for shock wave treatment units |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997010758A1 (en) * | 1995-09-20 | 1997-03-27 | Storz Medical Ag | Device for treating body tissue and crushing calculi |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0610434A1 (en) | 1994-08-17 |
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