WO1993006241A1 - Gene probe biosensor method - Google Patents
Gene probe biosensor method Download PDFInfo
- Publication number
- WO1993006241A1 WO1993006241A1 PCT/GB1992/001698 GB9201698W WO9306241A1 WO 1993006241 A1 WO1993006241 A1 WO 1993006241A1 GB 9201698 W GB9201698 W GB 9201698W WO 9306241 A1 WO9306241 A1 WO 9306241A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- oligonucleotide
- sequence
- dna
- immobilised
- rna
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
Abstract
Description
Claims
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK92919549T DK0604506T3 (en) | 1991-09-16 | 1992-09-16 | Gene probe biosensor method |
GB9402823A GB2274710B (en) | 1991-09-16 | 1992-09-16 | Detection of nucleic acid sequences in a sample using an oligonucleotide immobilised on a waveguide |
CA002116239A CA2116239C (en) | 1991-09-16 | 1992-09-16 | Gene probe biosensor method |
EP92919549A EP0604506B1 (en) | 1991-09-16 | 1992-09-16 | Gene probe biosensor method |
AU25641/92A AU665369B2 (en) | 1991-09-16 | 1992-09-16 | Gene probe biosensor method |
SK306-94A SK280713B6 (en) | 1991-09-16 | 1992-09-16 | The tissue detection, identification, and/or quantification method |
DE69227997T DE69227997T2 (en) | 1991-09-16 | 1992-09-16 | METHOD WITH A GENES PROBE BIOSENSOR |
KR1019940700843A KR100249288B1 (en) | 1991-09-16 | 1992-09-16 | Gene probe biosensor method |
JP50589793A JP3324607B2 (en) | 1991-09-16 | 1992-09-16 | Gene probe biosensor method |
US08/196,185 US5750337A (en) | 1991-09-16 | 1992-09-16 | Methods for detecting nucleic acid sequences using evanescent wave detection |
NO19940901A NO315380B1 (en) | 1991-09-16 | 1994-03-14 | Method for detection, identification and / or quantification of a material |
BG98660A BG62337B1 (en) | 1991-09-16 | 1994-03-15 | Biosensor method based on gene probe |
FI941220A FI108463B (en) | 1991-09-16 | 1994-03-15 | A genetic probes bio detector method |
GR990400807T GR3029722T3 (en) | 1991-09-16 | 1999-03-18 | Gene probe biosensor method. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9119735.0 | 1991-09-16 | ||
GB919119735A GB9119735D0 (en) | 1991-09-16 | 1991-09-16 | Gene probe biosensor method |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1993006241A1 true WO1993006241A1 (en) | 1993-04-01 |
Family
ID=10701461
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1992/001698 WO1993006241A1 (en) | 1991-09-16 | 1992-09-16 | Gene probe biosensor method |
Country Status (20)
Country | Link |
---|---|
US (1) | US5750337A (en) |
EP (1) | EP0604506B1 (en) |
JP (1) | JP3324607B2 (en) |
KR (1) | KR100249288B1 (en) |
AT (1) | ATE174968T1 (en) |
AU (1) | AU665369B2 (en) |
BG (1) | BG62337B1 (en) |
CA (1) | CA2116239C (en) |
CZ (1) | CZ286927B6 (en) |
DE (1) | DE69227997T2 (en) |
DK (1) | DK0604506T3 (en) |
ES (1) | ES2125272T3 (en) |
FI (1) | FI108463B (en) |
GB (2) | GB9119735D0 (en) |
GR (1) | GR3029722T3 (en) |
HU (1) | HU218596B (en) |
NO (1) | NO315380B1 (en) |
RU (1) | RU2116349C1 (en) |
SK (1) | SK280713B6 (en) |
WO (1) | WO1993006241A1 (en) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995026416A1 (en) * | 1994-03-25 | 1995-10-05 | Research Corporation Technologies, Inc. | Nucleic acid biosensor diagnostics |
EP0717779A1 (en) * | 1992-04-06 | 1996-06-26 | Abbott Laboratories | Method and device for detection of nucleic acid or analyte using total internal reflectance |
WO1996019587A2 (en) * | 1994-12-22 | 1996-06-27 | Abbott Laboratories | Methods of immobilizing oligonucleotides to solid support materials and methods of using support bound oligonucleotides |
US5599668A (en) * | 1994-09-22 | 1997-02-04 | Abbott Laboratories | Light scattering optical waveguide method for detecting specific binding events |
WO1997004129A1 (en) * | 1995-07-14 | 1997-02-06 | Biacore Ab | Method for nucleic acid sequencing |
EP0957354A2 (en) * | 1998-03-20 | 1999-11-17 | IA Inc. | Method and apparatus for measuring binding between biological molecules |
US6110749A (en) * | 1996-03-01 | 2000-08-29 | Beckman Coulter, Inc. | System for simultaneously conducting multiple ligand binding assays |
US6503711B1 (en) | 1997-06-18 | 2003-01-07 | Ulrich J. Krull | Nucleic acid biosensor diagnostics |
EP1064406B1 (en) * | 1998-03-19 | 2004-08-04 | Novartis AG | SOLUTION PHASE NUCLEIC ACID hybridisation SANDWICH ASSAY |
EP2231876A1 (en) * | 2007-12-24 | 2010-09-29 | Honeywell International Inc. | A programmable oligonucleotme micro array |
US20100316999A1 (en) * | 1997-07-28 | 2010-12-16 | Daniel Henry Densham | Nucleic Acid Sequence Analysis |
WO2013003849A3 (en) * | 2011-06-30 | 2013-05-10 | Bioquanta Sa | Process and apparatus for quantifying nucleic acid in a sample |
US8502166B2 (en) | 2008-02-04 | 2013-08-06 | Koninklijke Philips N.V. | Molecular diagnostic system based on evanescent illumination and fluorescence |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5690894A (en) * | 1995-05-23 | 1997-11-25 | The Regents Of The University Of California | High density array fabrication and readout method for a fiber optic biosensor |
US5832165A (en) * | 1996-08-28 | 1998-11-03 | University Of Utah Research Foundation | Composite waveguide for solid phase binding assays |
DE19730359A1 (en) * | 1997-07-15 | 1999-01-21 | Boehringer Mannheim Gmbh | Integrated method and system for amplification and detection of nucleic acids |
GB2335035B (en) * | 1998-03-03 | 2003-05-28 | Brax Genomics Ltd | Screening for functional antisense agents |
US6429023B1 (en) | 1998-07-20 | 2002-08-06 | Shayda Technologies, Inc. | Biosensors with polymeric optical waveguides |
DE60045059D1 (en) * | 1999-04-20 | 2010-11-18 | Nat Inst Of Advanced Ind Scien | Methods and probes for determining the concentration of nucleic acid molecules and methods for analyzing the data obtained |
WO2002033005A2 (en) * | 2000-10-19 | 2002-04-25 | Trans Photonics, L.L.C. | Novel substituted-polyaryl chromophoric compounds |
AR031640A1 (en) * | 2000-12-08 | 2003-09-24 | Applied Research Systems | ISOTHERMAL AMPLIFICATION OF NUCLEIC ACIDS IN A SOLID SUPPORT |
US6597499B2 (en) | 2001-01-25 | 2003-07-22 | Olympus Optical Co., Ltd. | Total internal reflection fluorescence microscope having a conventional white-light source |
US20040241699A1 (en) * | 2001-10-04 | 2004-12-02 | Giovanni Zocchi | Detection of polynucleotide hybridization |
DE102004016247A1 (en) * | 2004-04-02 | 2005-10-20 | Chromeon Gmbh | Solid support systems for homogeneous detection of interactions of biomolecules without washing steps |
US20060088844A1 (en) * | 2004-10-22 | 2006-04-27 | Honeywell International Inc. | Real-time PCR microarray based on evanescent wave biosensor |
GB0522310D0 (en) | 2005-11-01 | 2005-12-07 | Solexa Ltd | Methods of preparing libraries of template polynucleotides |
GB0524069D0 (en) * | 2005-11-25 | 2006-01-04 | Solexa Ltd | Preparation of templates for solid phase amplification |
JP5429962B2 (en) * | 2006-03-16 | 2014-02-26 | 国立大学法人秋田大学 | Nucleic acid detection method and nucleic acid detection kit |
EP2021503A1 (en) * | 2006-03-17 | 2009-02-11 | Solexa Ltd. | Isothermal methods for creating clonal single molecule arrays |
US7824902B2 (en) * | 2006-11-03 | 2010-11-02 | Mark Selker | Optical interface for disposable bioreactors |
EP1935496A1 (en) | 2006-12-22 | 2008-06-25 | Eppendorf Array Technologies SA | Device and/or method for the detection of amplified nucleotides sequences on micro-arrays |
US8124944B2 (en) * | 2007-01-17 | 2012-02-28 | Honeywell International Inc. | Microarray reader based on evanescent wave detection and method of reading a microarray |
WO2008093098A2 (en) | 2007-02-02 | 2008-08-07 | Illumina Cambridge Limited | Methods for indexing samples and sequencing multiple nucleotide templates |
EP2227537A4 (en) * | 2007-12-24 | 2014-05-07 | Honeywell Int Inc | A reactor for the quantitative analysis of nucleic acids |
US9539571B2 (en) | 2010-01-20 | 2017-01-10 | Honeywell International Inc. | Method to increase detection efficiency of real time PCR microarray by quartz material |
KR102376437B1 (en) | 2016-10-27 | 2022-03-17 | 바나디스 다이아그노스틱스 | How to process rolling circle amplification products |
BR112021017166A2 (en) * | 2019-03-01 | 2021-11-09 | Vidya Holdings Ltd | Assay cartridge for detecting a target component in a fluid, and method for manufacturing an array of assay cartridges |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0144914A2 (en) * | 1983-12-12 | 1985-06-19 | Miles Inc. | Hybridization assay employing labeled pairs of hybrid binding reagents |
EP0070687B1 (en) * | 1981-07-17 | 1985-10-16 | Amoco Corporation | Light-emitting polynucleotide hybridization diagnostic method |
EP0245206A1 (en) * | 1986-05-05 | 1987-11-11 | IntraCel Corporation | Analytical method for detecting and measuring specifically sequenced nucleic acid |
BE1000572A4 (en) * | 1987-05-20 | 1989-02-07 | Block Myron J | Appts. for analysing polynucleotide in liq. sample - using internal reflection cell coated with complementary single strand sequences and selective fluorescent dye |
WO1990013666A1 (en) * | 1989-05-11 | 1990-11-15 | Amersham International Plc | Sequencing method |
WO1991002981A1 (en) * | 1989-08-25 | 1991-03-07 | Amersham International Plc | Assay method |
EP0435150A2 (en) * | 1989-12-29 | 1991-07-03 | Enzo Biochem, Inc. | Amplification capture assay |
EP0478319A1 (en) * | 1990-09-28 | 1992-04-01 | Kabushiki Kaisha Toshiba | Gene detection method |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4582809A (en) * | 1982-06-14 | 1986-04-15 | Myron J. Block | Apparatus including optical fiber for fluorescence immunoassay |
US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US5242797A (en) * | 1986-03-21 | 1993-09-07 | Myron J. Block | Nucleic acid assay method |
AU622426B2 (en) * | 1987-12-11 | 1992-04-09 | Abbott Laboratories | Assay using template-dependent nucleic acid probe reorganization |
GB8902689D0 (en) * | 1989-02-07 | 1989-03-30 | Ici Plc | Assay method |
USH1398H (en) * | 1990-12-28 | 1995-01-03 | Campbell; James R. | DNA-based fluourescent sensor |
-
1991
- 1991-09-16 GB GB919119735A patent/GB9119735D0/en active Pending
-
1992
- 1992-09-16 GB GB9402823A patent/GB2274710B/en not_active Revoked
- 1992-09-16 WO PCT/GB1992/001698 patent/WO1993006241A1/en active IP Right Grant
- 1992-09-16 HU HU9400770A patent/HU218596B/en not_active IP Right Cessation
- 1992-09-16 CZ CZ1994521A patent/CZ286927B6/en not_active IP Right Cessation
- 1992-09-16 DK DK92919549T patent/DK0604506T3/en active
- 1992-09-16 JP JP50589793A patent/JP3324607B2/en not_active Expired - Fee Related
- 1992-09-16 US US08/196,185 patent/US5750337A/en not_active Expired - Lifetime
- 1992-09-16 RU RU94019336A patent/RU2116349C1/en not_active IP Right Cessation
- 1992-09-16 CA CA002116239A patent/CA2116239C/en not_active Expired - Fee Related
- 1992-09-16 AT AT92919549T patent/ATE174968T1/en not_active IP Right Cessation
- 1992-09-16 AU AU25641/92A patent/AU665369B2/en not_active Ceased
- 1992-09-16 EP EP92919549A patent/EP0604506B1/en not_active Expired - Lifetime
- 1992-09-16 DE DE69227997T patent/DE69227997T2/en not_active Expired - Lifetime
- 1992-09-16 SK SK306-94A patent/SK280713B6/en not_active IP Right Cessation
- 1992-09-16 ES ES92919549T patent/ES2125272T3/en not_active Expired - Lifetime
- 1992-09-16 KR KR1019940700843A patent/KR100249288B1/en not_active IP Right Cessation
-
1994
- 1994-03-14 NO NO19940901A patent/NO315380B1/en not_active IP Right Cessation
- 1994-03-15 FI FI941220A patent/FI108463B/en active
- 1994-03-15 BG BG98660A patent/BG62337B1/en unknown
-
1999
- 1999-03-18 GR GR990400807T patent/GR3029722T3/en unknown
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0070687B1 (en) * | 1981-07-17 | 1985-10-16 | Amoco Corporation | Light-emitting polynucleotide hybridization diagnostic method |
EP0144914A2 (en) * | 1983-12-12 | 1985-06-19 | Miles Inc. | Hybridization assay employing labeled pairs of hybrid binding reagents |
EP0245206A1 (en) * | 1986-05-05 | 1987-11-11 | IntraCel Corporation | Analytical method for detecting and measuring specifically sequenced nucleic acid |
BE1000572A4 (en) * | 1987-05-20 | 1989-02-07 | Block Myron J | Appts. for analysing polynucleotide in liq. sample - using internal reflection cell coated with complementary single strand sequences and selective fluorescent dye |
WO1990013666A1 (en) * | 1989-05-11 | 1990-11-15 | Amersham International Plc | Sequencing method |
WO1991002981A1 (en) * | 1989-08-25 | 1991-03-07 | Amersham International Plc | Assay method |
EP0435150A2 (en) * | 1989-12-29 | 1991-07-03 | Enzo Biochem, Inc. | Amplification capture assay |
EP0478319A1 (en) * | 1990-09-28 | 1992-04-01 | Kabushiki Kaisha Toshiba | Gene detection method |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1130116A2 (en) * | 1992-04-06 | 2001-09-05 | Abbott Laboratories | Method and device for detection of nucleic acid using total internal reflectance |
EP0717779A1 (en) * | 1992-04-06 | 1996-06-26 | Abbott Laboratories | Method and device for detection of nucleic acid or analyte using total internal reflectance |
EP0717779A4 (en) * | 1992-04-06 | 1998-03-11 | Abbott Lab | Method and device for detection of nucleic acid or analyte using total internal reflectance |
EP1130116A3 (en) * | 1992-04-06 | 2004-01-14 | Abbott Laboratories | Method and device for detection of nucleic acid using total internal reflectance |
WO1995026416A1 (en) * | 1994-03-25 | 1995-10-05 | Research Corporation Technologies, Inc. | Nucleic acid biosensor diagnostics |
US5599668A (en) * | 1994-09-22 | 1997-02-04 | Abbott Laboratories | Light scattering optical waveguide method for detecting specific binding events |
WO1996019587A2 (en) * | 1994-12-22 | 1996-06-27 | Abbott Laboratories | Methods of immobilizing oligonucleotides to solid support materials and methods of using support bound oligonucleotides |
WO1996019587A3 (en) * | 1994-12-22 | 1996-09-19 | Abbott Lab | Methods of immobilizing oligonucleotides to solid support materials and methods of using support bound oligonucleotides |
WO1997004129A1 (en) * | 1995-07-14 | 1997-02-06 | Biacore Ab | Method for nucleic acid sequencing |
US6110749A (en) * | 1996-03-01 | 2000-08-29 | Beckman Coulter, Inc. | System for simultaneously conducting multiple ligand binding assays |
US6503711B1 (en) | 1997-06-18 | 2003-01-07 | Ulrich J. Krull | Nucleic acid biosensor diagnostics |
US20100316999A1 (en) * | 1997-07-28 | 2010-12-16 | Daniel Henry Densham | Nucleic Acid Sequence Analysis |
EP1064406B1 (en) * | 1998-03-19 | 2004-08-04 | Novartis AG | SOLUTION PHASE NUCLEIC ACID hybridisation SANDWICH ASSAY |
EP0957354A3 (en) * | 1998-03-20 | 2000-03-22 | IA Inc. | Method and apparatus for measuring binding between biological molecules |
EP0957354A2 (en) * | 1998-03-20 | 1999-11-17 | IA Inc. | Method and apparatus for measuring binding between biological molecules |
EP2231876A1 (en) * | 2007-12-24 | 2010-09-29 | Honeywell International Inc. | A programmable oligonucleotme micro array |
EP2231876A4 (en) * | 2007-12-24 | 2011-10-12 | Honeywell Int Inc | A programmable oligonucleotide micro array |
US9005931B2 (en) | 2007-12-24 | 2015-04-14 | Honeywell International Inc. | Programmable oligonucleotide micro array |
US8502166B2 (en) | 2008-02-04 | 2013-08-06 | Koninklijke Philips N.V. | Molecular diagnostic system based on evanescent illumination and fluorescence |
WO2013003849A3 (en) * | 2011-06-30 | 2013-05-10 | Bioquanta Sa | Process and apparatus for quantifying nucleic acid in a sample |
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