WO1993000050A1 - Pharmaceutical formulations of osteogenic proteins - Google Patents
Pharmaceutical formulations of osteogenic proteins Download PDFInfo
- Publication number
- WO1993000050A1 WO1993000050A1 PCT/US1992/005309 US9205309W WO9300050A1 WO 1993000050 A1 WO1993000050 A1 WO 1993000050A1 US 9205309 W US9205309 W US 9205309W WO 9300050 A1 WO9300050 A1 WO 9300050A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition
- poly
- osteogenic protein
- acid
- matrix component
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
Abstract
Description
Claims
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP50162593A JP3351525B2 (en) | 1991-06-21 | 1992-06-22 | Osteogenic protein pharmaceutical formulation |
KR1019930703979A KR0145278B1 (en) | 1991-06-21 | 1992-06-22 | Pharmaceutical formulations of osteogenic proteins |
DE69213739T DE69213739T2 (en) | 1991-06-21 | 1992-06-22 | MEDICINAL PRODUCTS CONTAINING OSTEOGENIC PROTEINS |
US08/081,378 US5597897A (en) | 1991-06-21 | 1992-06-22 | Pharmaceutical formulations of osteogenic proteins |
AU22542/92A AU663328B2 (en) | 1991-06-21 | 1992-06-22 | Pharmaceutical formulations of osteogenic proteins |
EP92914339A EP0591392B1 (en) | 1991-06-21 | 1992-06-22 | Pharmaceutical formulations of osteogenic proteins |
CA002111199A CA2111199C (en) | 1991-06-21 | 1992-06-22 | Pharmaceutical formulations of osteogenic proteins |
NO934573D NO934573D0 (en) | 1991-06-21 | 1993-12-13 | Pharmaceutical Formulations of Osteogenic Proteins |
NO934573A NO307402B1 (en) | 1991-06-21 | 1993-12-13 | Pharmaceutical formulations of osteogenic proteins |
FI935732A FI109274B (en) | 1991-06-21 | 1993-12-20 | Process for preparing a pharmaceutical composition containing osteogenic protein |
GR960402998T GR3021627T3 (en) | 1991-06-21 | 1996-11-14 | Pharmaceutical formulations of osteogenic proteins |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71872191A | 1991-06-21 | 1991-06-21 | |
US718,721 | 1991-06-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1993000050A1 true WO1993000050A1 (en) | 1993-01-07 |
Family
ID=24887221
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1992/005309 WO1993000050A1 (en) | 1991-06-21 | 1992-06-22 | Pharmaceutical formulations of osteogenic proteins |
Country Status (15)
Country | Link |
---|---|
US (1) | US5597897A (en) |
EP (1) | EP0591392B1 (en) |
JP (1) | JP3351525B2 (en) |
KR (1) | KR0145278B1 (en) |
AT (1) | ATE142460T1 (en) |
AU (1) | AU663328B2 (en) |
CA (1) | CA2111199C (en) |
DE (1) | DE69213739T2 (en) |
DK (1) | DK0591392T3 (en) |
ES (1) | ES2094359T3 (en) |
FI (1) | FI109274B (en) |
GR (1) | GR3021627T3 (en) |
MX (1) | MX9203083A (en) |
NO (2) | NO307402B1 (en) |
WO (1) | WO1993000050A1 (en) |
Cited By (50)
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WO1996009078A1 (en) * | 1994-09-19 | 1996-03-28 | Genetics Institute, Inc. | Formulations for delivery of osteogenic proteins |
EP0704532A2 (en) | 1994-06-10 | 1996-04-03 | United States Surgical Corporation | Recombinant chimeric proteins and methods of use thereof |
EP0724459A1 (en) * | 1993-09-10 | 1996-08-07 | Genetics Institute, Inc. | Formulations for delivery of osteogenic proteins |
US5674292A (en) * | 1995-06-07 | 1997-10-07 | Stryker Corporation | Terminally sterilized osteogenic devices and preparation thereof |
US5674844A (en) * | 1991-03-11 | 1997-10-07 | Creative Biomolecules, Inc. | Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases |
US5700774A (en) * | 1996-03-26 | 1997-12-23 | Genetics Institute, Inc. | Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same |
WO1998017257A1 (en) * | 1996-10-19 | 1998-04-30 | Quadrant Healthcare (Uk) Limited | Porous microcapsules and their use as therapeutic and diagnostic vehicles |
WO1998031788A1 (en) * | 1997-01-21 | 1998-07-23 | Genetics Institute, Inc. | Injectable formulations for treatment of osteoporotic bone |
EP0608313B1 (en) * | 1991-10-11 | 2000-02-09 | Genetics Institute, Inc. | Formulations of blood clot-polymer matrix for delivery of osteogenic proteins |
WO2000018444A1 (en) * | 1998-09-30 | 2000-04-06 | Takeda Chemical Industries, Ltd. | Bone repair materials/artificial bone compositions |
EP1047442A1 (en) * | 1997-06-03 | 2000-11-02 | Marcel E. Nimni | Bone morphogenetic proteins and their use in bone growth |
US6197759B1 (en) | 1997-10-02 | 2001-03-06 | Roche Diagnostics Gmbh | Osteoblast-specific mitogens and drugs containing such compounds |
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US6468543B1 (en) | 1999-05-03 | 2002-10-22 | Zymogenetics, Inc. | Methods for promoting growth of bone using ZVEGF4 |
US6492508B1 (en) | 1996-06-03 | 2002-12-10 | United States Surgical Corp. A Division Of Tyco Healthcare Group | Nucleic acids encoding extracellular matrix proteins |
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US6911553B1 (en) | 1997-10-02 | 2005-06-28 | Roche Diagnostics Gmbh | Osteoblast-specific mitogens and drugs containing such compounds |
EP1578348A2 (en) * | 2002-02-08 | 2005-09-28 | Wyeth | Formulation comprising bioactive agents and method of using same |
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Also Published As
Publication number | Publication date |
---|---|
US5597897A (en) | 1997-01-28 |
DE69213739T2 (en) | 1997-02-20 |
AU2254292A (en) | 1993-01-25 |
AU663328B2 (en) | 1995-10-05 |
NO934573L (en) | 1993-12-13 |
MX9203083A (en) | 1994-08-31 |
JP3351525B2 (en) | 2002-11-25 |
ES2094359T3 (en) | 1997-01-16 |
NO307402B1 (en) | 2000-04-03 |
EP0591392B1 (en) | 1996-09-11 |
CA2111199A1 (en) | 1993-01-07 |
GR3021627T3 (en) | 1997-02-28 |
DK0591392T3 (en) | 1996-09-30 |
JPH06508777A (en) | 1994-10-06 |
ATE142460T1 (en) | 1996-09-15 |
DE69213739D1 (en) | 1996-10-17 |
NO934573D0 (en) | 1993-12-13 |
EP0591392A1 (en) | 1994-04-13 |
FI109274B (en) | 2002-06-28 |
FI935732A (en) | 1993-12-20 |
CA2111199C (en) | 2008-08-05 |
KR0145278B1 (en) | 1998-07-15 |
FI935732A0 (en) | 1993-12-20 |
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