WO1992019195A1 - Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products - Google Patents
Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products Download PDFInfo
- Publication number
- WO1992019195A1 WO1992019195A1 PCT/US1992/003327 US9203327W WO9219195A1 WO 1992019195 A1 WO1992019195 A1 WO 1992019195A1 US 9203327 W US9203327 W US 9203327W WO 9219195 A1 WO9219195 A1 WO 9219195A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cells
- jacket
- vehicle
- core
- immunoisolatory vehicle
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0012—Cell encapsulation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0062—General methods for three-dimensional culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0613—Cells from endocrine organs
- C12N5/0614—Adrenal gland
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0656—Adult fibroblasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
- A61K2035/128—Immunoprotecting barriers, e.g. jackets, diffusion chambers capsules, e.g. microcapsules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Abstract
Description
Claims
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002109085A CA2109085C (en) | 1991-04-25 | 1992-04-22 | Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products |
JP51189892A JP4215273B2 (en) | 1991-04-25 | 1992-04-22 | Implantable and biocompatible immunoblocking vehicle for the release of selected therapeutic agents |
AU20041/92A AU666118B2 (en) | 1991-04-25 | 1992-04-22 | Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products |
DE69221484T DE69221484T2 (en) | 1991-04-25 | 1992-04-22 | IMPLANTABLE, BIOCOMPATIBLE IMMUNISOLATOR SUPPORT SUBSTANCE FOR DELIVERING SELECTED, THERAPEUTIC PRODUCTS |
EP92912606A EP0585368B1 (en) | 1991-04-25 | 1992-04-22 | Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products |
FI934545A FI934545A (en) | 1991-04-25 | 1993-10-14 | BIOKOMPATIBEL IMMUNOISOLOLAD BAERARE FOER OEVERLAEMNANDET AV EN VALD THERAPEUTIC PRODUCT |
NO933842A NO308198B1 (en) | 1991-04-25 | 1993-10-25 | Implantable, biocompatible, immunoisolatory carrier for delivery of selected therapeutic products, as well as methods of making carriers |
US08/436,281 US5955095A (en) | 1992-04-22 | 1993-11-16 | Microporous macrocapsules |
US08/449,837 US5874099A (en) | 1991-04-25 | 1995-05-24 | Methods for making immunoisolatary implantable vehicles with a biocompatible jacket and a biocompatible matrix core |
US08/449,062 US5871767A (en) | 1991-04-25 | 1995-05-24 | Methods for treatment or prevention of neurodegenerative conditions using immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core |
GR970402942T GR3025301T3 (en) | 1991-04-25 | 1997-11-06 | Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products |
HK98100825A HK1001832A1 (en) | 1991-04-25 | 1998-02-04 | Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products |
US09/148,671 US6083523A (en) | 1991-04-25 | 1998-09-04 | Implantable biocompatable immunoisolatory vehicle for delivery of selected therapeutic products |
US10/007,344 US20020150603A1 (en) | 1991-04-25 | 2001-10-25 | Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products |
US10/624,081 US6960351B2 (en) | 1991-04-25 | 2003-07-21 | Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69240391A | 1991-04-25 | 1991-04-25 | |
US692,403 | 1991-04-25 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US69240391A Continuation-In-Part | 1991-04-25 | 1991-04-25 |
Related Child Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/436,281 Continuation-In-Part US5955095A (en) | 1992-04-22 | 1993-11-16 | Microporous macrocapsules |
US08/179,151 Continuation-In-Part US5800828A (en) | 1991-04-25 | 1994-01-10 | Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products |
US08/449,837 Division US5874099A (en) | 1991-04-25 | 1995-05-24 | Methods for making immunoisolatary implantable vehicles with a biocompatible jacket and a biocompatible matrix core |
US09/148,671 Continuation-In-Part US6083523A (en) | 1991-04-25 | 1998-09-04 | Implantable biocompatable immunoisolatory vehicle for delivery of selected therapeutic products |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1992019195A1 true WO1992019195A1 (en) | 1992-11-12 |
Family
ID=24780436
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1992/003327 WO1992019195A1 (en) | 1991-04-25 | 1992-04-22 | Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products |
Country Status (15)
Country | Link |
---|---|
US (10) | US5800828A (en) |
EP (1) | EP0585368B1 (en) |
JP (2) | JP4215273B2 (en) |
AT (1) | ATE156344T1 (en) |
AU (2) | AU666118B2 (en) |
CA (1) | CA2109085C (en) |
DE (1) | DE69221484T2 (en) |
DK (1) | DK0585368T3 (en) |
ES (1) | ES2107537T3 (en) |
FI (1) | FI934545A (en) |
GR (1) | GR3025301T3 (en) |
HK (1) | HK1001832A1 (en) |
NO (1) | NO308198B1 (en) |
SG (1) | SG47470A1 (en) |
WO (1) | WO1992019195A1 (en) |
Cited By (128)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995005452A2 (en) * | 1993-08-12 | 1995-02-23 | Cytotherapeutics, Inc. | Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules |
EP0674497A1 (en) * | 1992-11-16 | 1995-10-04 | Brown University Research Foundation | Microporous macrocapsules |
EP0679402A2 (en) * | 1994-04-25 | 1995-11-02 | Research Development Corporation Of Japan | Biologically active substance-secreting hybrid gel |
US5550050A (en) * | 1994-04-15 | 1996-08-27 | Cytotherapeutics, Inc. | Method for implanting encapsulated cells in a host |
WO1996028029A1 (en) * | 1995-03-10 | 1996-09-19 | Biohybrid Technologies, Inc. | Immunoisolation |
EP0733101A1 (en) * | 1993-12-10 | 1996-09-25 | Cytotherapeutics | Glucose responsive insulin secreting beta-cell lines and method for producing same |
WO1996040887A1 (en) * | 1995-06-07 | 1996-12-19 | Children's Medical Center Corporation | Immunoprotective barrier for transplantation of cells |
WO1996040871A1 (en) * | 1995-06-07 | 1996-12-19 | Cytotherapeutics, Inc. | Bioartificial organs comprising open pored foam-like membranes |
WO1997012635A1 (en) * | 1995-10-02 | 1997-04-10 | Cytotherapeutics, Inc. | Method for treating amyotrophic lateral sclerosis |
WO1997020569A2 (en) * | 1995-12-07 | 1997-06-12 | Encelle, Inc. | Bioartificial devices and cellular matrices therefor |
WO1997037003A1 (en) * | 1996-03-29 | 1997-10-09 | Desmos, Inc. | Laminin 5 for growth of pancreatic islet cells |
WO1997038707A1 (en) * | 1996-04-17 | 1997-10-23 | Cytotherapeutics, Inc. | Method and device for delivery of apoptosis-inducing molecules |
US5681740A (en) * | 1995-06-05 | 1997-10-28 | Cytotherapeutics, Inc. | Apparatus and method for storage and transporation of bioartificial organs |
WO1997044065A2 (en) * | 1996-05-20 | 1997-11-27 | Cytotherapeutics, Inc. | Device and method for encapsulated gene therapy |
US5709854A (en) * | 1993-04-30 | 1998-01-20 | Massachusetts Institute Of Technology | Tissue formation by injecting a cell-polymeric solution that gels in vivo |
WO1998019695A1 (en) * | 1996-11-05 | 1998-05-14 | Modex Therapeutiques | Device and method for delivery of erythropoietin |
US5776747A (en) * | 1994-07-20 | 1998-07-07 | Cytotherapeutics, Inc. | Method for controlling the distribution of cells within a bioartificial organ using polycthylene oxide-poly (dimethylsiloxane) copolymer |
US5786216A (en) * | 1987-11-17 | 1998-07-28 | Cytotherapeutics, Inc. | Inner-supported, biocompatible cell capsules |
US5824331A (en) * | 1992-02-24 | 1998-10-20 | Encelle, Inc. | Bioartificial devices and cellular matrices therefor |
US5834005A (en) * | 1992-02-24 | 1998-11-10 | Encelle, Inc. | Bioartificial devices and cellular matrices therefor |
US5834029A (en) * | 1994-07-20 | 1998-11-10 | Cytotherapeutics, Inc. | Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment |
US5853385A (en) * | 1994-08-26 | 1998-12-29 | Cytotherapeutics, Inc. | Encapsulated PC12 cell transplants for treatment of Parkinson's disease |
WO1999005989A2 (en) * | 1997-08-01 | 1999-02-11 | Biohybrid Technologies, Inc. | Devices for providing therapeutic substances |
US5902745A (en) * | 1995-09-22 | 1999-05-11 | Gore Hybrid Technologies, Inc. | Cell encapsulation device |
US5908623A (en) * | 1993-08-12 | 1999-06-01 | Cytotherapeutics, Inc. | Compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules |
US5922339A (en) * | 1998-01-27 | 1999-07-13 | Usala; Anton-Lewis | Compositions and methods for biocompatible implants |
US5935849A (en) * | 1994-07-20 | 1999-08-10 | Cytotherapeutics, Inc. | Methods and compositions of growth control for cells encapsulated within bioartificial organs |
US5980889A (en) * | 1993-08-10 | 1999-11-09 | Gore Hybrid Technologies, Inc. | Cell encapsulating device containing a cell displacing core for maintaining cell viability |
WO1999060105A1 (en) * | 1998-05-15 | 1999-11-25 | Modex Therapeutiques, S.A. | Flat sheet cell encapsulation device |
WO2000012066A1 (en) * | 1998-08-26 | 2000-03-09 | Norsk Hydro Asa | Alginate capsules for use in the treatment of brain tumour |
US6054142A (en) * | 1996-08-01 | 2000-04-25 | Cyto Therapeutics, Inc. | Biocompatible devices with foam scaffolds |
US6121415A (en) * | 1997-07-09 | 2000-09-19 | Genentech, Inc. | ErbB4 receptor-specific neuregolin related ligands and uses therefor |
US6156728A (en) * | 1996-11-01 | 2000-12-05 | Genentech, Inc. | Treatment of inner ear hair cells |
EP1073420A2 (en) * | 1998-05-14 | 2001-02-07 | Abraham Shahar | Specially devised neuronal implants for reconstruction of damaged central nervous system |
US6231881B1 (en) | 1992-02-24 | 2001-05-15 | Anton-Lewis Usala | Medium and matrix for long-term proliferation of cells |
US6303136B1 (en) | 1998-04-13 | 2001-10-16 | Neurotech S.A. | Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane |
US6352707B1 (en) | 1992-02-24 | 2002-03-05 | Anton-Lewis Usala | Transplant encapsulation in a hydrogel matrix to obscure immune recognition |
US6361771B1 (en) | 1999-04-06 | 2002-03-26 | Neurotech S.A. | ARPE-19 as a platform cell line for encapsulated cell-based delivery |
US6436427B1 (en) | 1996-03-22 | 2002-08-20 | Neurotech S.A. | Device and method for treating ophthalmic diseases |
US6495364B2 (en) * | 1995-05-23 | 2002-12-17 | Neurotech, S.A. | Mx-1 conditionally immortalized cells |
US6593290B1 (en) | 1996-11-01 | 2003-07-15 | Genentech, Inc. | Treatment of inner ear hair cells |
WO2004108760A2 (en) | 2003-06-10 | 2004-12-16 | Nsgene A/S | Improved secretion of neublastin |
AU779272B2 (en) * | 1994-04-25 | 2005-01-13 | Genentech Inc. | Biologically active substance-secreting hybrid gel |
WO2005020677A1 (en) | 2003-08-29 | 2005-03-10 | The Walter And Eliza Hall Institute Of Medical Research | Method of selecting animal models from animals which have been subject to mutagenesis, and the use of myb transcription factors for screening |
US6878543B1 (en) | 1999-10-25 | 2005-04-12 | Nsgene Sa | Cultures of GFAP+ nestin+ cells that differentiate to neurons |
WO2005060992A1 (en) | 2003-12-24 | 2005-07-07 | The Walter And Eliza Hall Institute Of Medical Research | Therapeutic agents and uses therefor |
WO2005108981A1 (en) | 2004-05-12 | 2005-11-17 | The Walter And Eliza Hall Institute Of Medical Research | A method of cell isolation |
US6992062B2 (en) | 2000-05-31 | 2006-01-31 | Encelle, Inc. | Method of stimulation hair growth |
US6994856B1 (en) | 1997-07-24 | 2006-02-07 | Genentech, Inc. | ErbB4 receptor-specific neuregulin related ligands and uses therefor |
US7125837B1 (en) | 1999-02-26 | 2006-10-24 | University Of Utah Research Foundation | Elastin-based compositions |
US7303814B2 (en) | 2002-02-21 | 2007-12-04 | Encelle, Inc. | Immobilized bioactive hydrogel matrices as surface coatings |
WO2008011006A2 (en) | 2006-07-18 | 2008-01-24 | University Of Utah Research Foundation | Methods for treating pain and screening analgesic compounds |
US7361333B2 (en) | 1995-10-26 | 2008-04-22 | Latta Paul P | Prevention of diabetes through induction of immunological tolerance |
EP2075254A1 (en) | 2004-03-30 | 2009-07-01 | NsGene A/S | Therapeutic use of a growth factor, NsG33 |
WO2009125332A1 (en) * | 2008-04-07 | 2009-10-15 | Peter Bromley | New and safe procedure for immunization against infectious diseases agents |
WO2009126251A2 (en) | 2008-04-07 | 2009-10-15 | Nupotential, Inc. | Reprogramming a cell by inducing a pluripotent gene through use of an hdac modulator |
EP2119728A1 (en) | 2002-11-29 | 2009-11-18 | The Corporation Of The Trustees Of The Order Of The Sisters Of Mercy In Queensland | Therapeutic and diagnostic agents |
US7655463B2 (en) | 2001-03-12 | 2010-02-02 | Biogen Idec Ma Inc. | Methods of activating RET receptor tyrosine kinase using neurotrophic factors |
US7662585B2 (en) | 1997-07-09 | 2010-02-16 | Genentech, Inc. | ErbB4 receptor-specific neuregulin related ligands and uses therefor |
WO2010075500A1 (en) | 2008-12-23 | 2010-07-01 | Stemcells California, Inc | Target populations of oligodendrocyte precursor cells and methods of making and using same |
EP2210617A1 (en) | 2003-10-20 | 2010-07-28 | NsGene A/S | Mammalian cells secreting Neurturin and their therapeutic use |
WO2010083841A2 (en) | 2009-01-23 | 2010-07-29 | Nsgene A/S | Improved cell lines and their use in encapsulated cell biodelivery |
WO2010083842A2 (en) | 2009-01-23 | 2010-07-29 | Nsgene A/S | Expression of neuropeptides in mammalian cells |
US7772201B2 (en) | 2004-11-17 | 2010-08-10 | “University of Maryland, Baltimore” | Highly branched HK peptides as effective carriers of siRNA |
US7820195B2 (en) | 2005-12-30 | 2010-10-26 | Neurotech Usa, Inc. | Micronized device for the delivery of biologically active molecules and methods of use thereof |
WO2010142007A1 (en) | 2009-06-09 | 2010-12-16 | Universidade Bandeirante De São Paulo - Academia Paulista Anchieta S/C Ltda | Pharmaceutical composition and use of the pharmaceutical composition for the treatment, prophylaxis or prevention of neoplastic diseases in humans and animals |
EP2290079A2 (en) | 1998-07-06 | 2011-03-02 | NsGene A/S | Neurotrophic factors |
WO2011039634A2 (en) | 2009-09-29 | 2011-04-07 | Universiteit Gent | Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose |
WO2011061629A2 (en) | 2009-11-19 | 2011-05-26 | Oxyrane Uk Limited | Yeast strains producing mammalian-like complex n-glycans |
US8012500B2 (en) | 2000-01-01 | 2011-09-06 | Beta-O2 Technologies Ltd. | Implantable device |
US8034635B2 (en) | 2002-05-16 | 2011-10-11 | Absorber Ab | Methods of donor specific crossmatching |
US8043271B2 (en) | 2008-11-26 | 2011-10-25 | Beta 02 Technologies Ltd. | Apparatus for transportation of oxygen to implanted cells |
US8088567B2 (en) | 2005-04-01 | 2012-01-03 | Nsgene A/S | Human immortalised neural precursor cell line |
EP2407484A2 (en) | 2005-06-24 | 2012-01-18 | The Walter And Eliza Hall Institute Of Medical Research | Therapeutic pro-apoptotic BH3-like molecules and methods for generating and/or selecting the same |
US8119114B2 (en) | 2001-02-01 | 2012-02-21 | Biogen Idec Ma Inc. | Polymer conjugates of mutated neublastin |
WO2012027494A1 (en) | 2010-08-24 | 2012-03-01 | Regents Of The University Of Minnesota | Bispecific targeting reagents |
WO2012042387A2 (en) | 2010-09-29 | 2012-04-05 | Oxyrane Uk Limited | De-mannosylation of phosphorylated n-glycans |
WO2012041328A1 (en) | 2010-10-01 | 2012-04-05 | Nsgene A/S | Use of meteorin for the treatment of allodynia, hyperalgesia, spontaneous pain and phantom pain |
WO2012042386A2 (en) | 2010-09-29 | 2012-04-05 | Oxyrane Uk Limited | Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated n-glycans and methods of facilitating mammalian cellular uptake of glycoproteins |
US8163875B2 (en) | 2003-04-18 | 2012-04-24 | Biogen Idec Ma Inc. | Polymer conjugated glycosylated neublastin |
WO2012075184A2 (en) | 2010-12-02 | 2012-06-07 | Neurotech Usa, Inc. | Cell lines that secrete anti-angiogenic antibody-scaffolds and soluble receptors and uses thereof |
US8263553B2 (en) | 2004-08-19 | 2012-09-11 | Biogen Idec Ma Inc. | Neublastin variants |
EP2508614A2 (en) | 2007-04-03 | 2012-10-10 | Oxyrane UK Limited | Glycosylation of molecules |
US8329655B2 (en) | 2007-05-01 | 2012-12-11 | Biogen Idec Ma Inc. | Methods for increasing vascularization |
US8334264B2 (en) | 2008-07-24 | 2012-12-18 | NsGenee A/S | Therapeutic use of a growth factor, METRNL |
US8357666B2 (en) | 2005-08-01 | 2013-01-22 | Nupotential, Inc. | Reprogramming a cell by inducing a pluripotent gene through RNA interference |
WO2013011438A1 (en) * | 2011-07-15 | 2013-01-24 | Piramal Enterprises Limited | Alginate tube drug delivery system and method therefor |
WO2013034157A1 (en) | 2011-09-05 | 2013-03-14 | Nsgene A/S | Treatment of allodynia, hyperalgsia, spontaneous pain, and phantom pain |
US8444630B2 (en) | 2000-01-12 | 2013-05-21 | Beta-O2 Technologies Ltd. | Oxygen supply for cell transplant and vascularization |
EP2609930A2 (en) | 2006-02-27 | 2013-07-03 | Biogen Idec MA Inc. | Treatments for neurological disorders |
WO2013136189A2 (en) | 2012-03-15 | 2013-09-19 | Oxyrane Uk Limited | Methods and materials for treatment of pompe's disease |
WO2013181424A1 (en) | 2012-05-30 | 2013-12-05 | Neurotech Usa, Inc. | Cryopreserved implantable cell culture devices and uses thereof |
US8722862B2 (en) | 2004-08-19 | 2014-05-13 | Biogen Idec Ma Inc. | Refolding transforming growth factor beta family proteins |
US8821431B2 (en) | 2007-09-07 | 2014-09-02 | Beta O2 Technologies Ltd. | Air gap for supporting cells |
WO2014138691A1 (en) | 2013-03-07 | 2014-09-12 | Viacyte, Inc. | 3-dimensional large capacity cell encapsulation device assembly |
WO2014136065A2 (en) | 2013-03-05 | 2014-09-12 | Oxyrane Uk Limited | Production of catalytically active type i sulfatase |
WO2014194284A1 (en) | 2013-05-31 | 2014-12-04 | Mcintosh J Michael | Conotoxin peptides, pharmaceutical compositions and uses thereof |
WO2015042580A1 (en) | 2013-09-23 | 2015-03-26 | Biogen Idec Ma Inc. | Compositions and methods for treatment of neuropathic pain |
US9155749B2 (en) | 2006-09-14 | 2015-10-13 | Medgenics Medical Israel Ltd. | Long lasting drug formulations |
USD755986S1 (en) | 2013-03-07 | 2016-05-10 | Viacyte, Inc. | Cell encapsulation device |
US9364427B2 (en) | 2005-05-17 | 2016-06-14 | Nsgene A/S | Implantable therapy system for treating a living being with an active factor |
US9381261B2 (en) | 2011-06-06 | 2016-07-05 | Kineta One, Llc | SHK-based pharmaceutical compositions and methods of manufacturing and using the same |
US9446168B2 (en) | 2010-06-07 | 2016-09-20 | Beta-O2 Technologies Ltd. | Multiple-layer immune barrier for donor cells |
US9452185B2 (en) | 2009-03-23 | 2016-09-27 | The Texas A&M University System | Mesenchymal stem cells and supports for tissue regeneration, repair and reconstruction |
US9540630B2 (en) | 2008-09-17 | 2017-01-10 | Beta O2 Technologies Ltd. | Optimization of alginate encapsulation of islets for transplantation |
US9561247B2 (en) | 2011-11-02 | 2017-02-07 | Tif Management, Llc | Methods and compositions for wound treatment |
WO2017070738A1 (en) | 2015-10-27 | 2017-05-04 | The University Of Queensland | A method of treatment and agents useful for same |
US9724367B2 (en) | 2010-11-10 | 2017-08-08 | Regenmed (Cayman) Ltd. | Injectable formulations for organ augmentation |
US9732356B2 (en) | 2011-06-07 | 2017-08-15 | Wisconsin Alumni Research Foundation | Hepatocyte based insulin gene therapy for diabetes |
US9775842B2 (en) | 2014-03-14 | 2017-10-03 | Rhode Island Hospital | Nanocarriers and their processing for diagnostics and therapeutics |
EP3272877A1 (en) | 2016-07-18 | 2018-01-24 | ETH Zurich | B-cell-mimetic cells |
WO2018015330A1 (en) | 2016-07-18 | 2018-01-25 | Eth Zurich | B-cell-mimetic cells |
US10016463B2 (en) | 2012-08-01 | 2018-07-10 | United Therapeutics Corporation | Treatment of pulmonary arterial hypertension with prostacyclin-treated endothelial progenitor cells |
US10071123B2 (en) | 2012-08-01 | 2018-09-11 | United Therapeutics Corporation | Treatment of pulmonary arterial hypertension with mesenchymal stem cells |
US10080730B2 (en) | 2013-01-09 | 2018-09-25 | United Therapeutics Corporation | Treatment of vasculopathy with prostacyclin and mesenchymal stem cells |
US10195140B2 (en) | 2015-05-27 | 2019-02-05 | Neurotech Usa, Inc. | Use of encapsulated cell therapy for treatment of ophthalmic disorders |
US10344300B2 (en) | 2011-01-04 | 2019-07-09 | Brown University | Nanotubes as carriers of nucleic acids into cells |
US10383981B2 (en) | 2002-02-21 | 2019-08-20 | Pioneer Surgical Technology, Inc. | Structural lattice and method of making same |
US10575765B2 (en) | 2014-10-13 | 2020-03-03 | Glusense Ltd. | Analyte-sensing device |
US10786446B2 (en) | 2013-03-14 | 2020-09-29 | Massachusetts Institute Of Technology | Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates |
US10871487B2 (en) | 2016-04-20 | 2020-12-22 | Glusense Ltd. | FRET-based glucose-detection molecules |
WO2020262642A1 (en) | 2019-06-28 | 2020-12-30 | 持田製薬株式会社 | Transplantation device using chemically crosslinked alginic acid |
EP3777827A1 (en) * | 2019-08-14 | 2021-02-17 | MaxiVax SA | Implantable capsule |
US20220000789A1 (en) * | 2018-09-27 | 2022-01-06 | Sigilon Therapeutics, Inc. | Implantable devices for cell therapy and related methods |
WO2022137345A1 (en) | 2020-12-22 | 2022-06-30 | 持田製薬株式会社 | Transplantation device using chemically crosslinked alginic acid |
US11571444B2 (en) | 2016-10-24 | 2023-02-07 | United Therapeutics Corporation | Enhancement of MSC immunomodulatory properties by treprostinil |
US11623023B2 (en) | 2016-11-10 | 2023-04-11 | Viacyte, Inc. | PDX1 pancreatic endoderm cells in cell delivery devices and methods thereof |
US11701379B2 (en) | 2018-03-26 | 2023-07-18 | Rhode Island Hospital | In vitro and in vivo intracellular delivery of siRNA via self-assembled nanopieces |
Families Citing this family (364)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0585368B1 (en) * | 1991-04-25 | 1997-08-06 | Brown University Research Foundation | Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products |
US6703017B1 (en) | 1994-04-28 | 2004-03-09 | Ixion Biotechnology, Inc. | Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures |
FR2724320B1 (en) * | 1994-09-13 | 1996-12-20 | Transgene Sa | NEW IMPLANT FOR THE TREATMENT OF ACQUIRED DISEASES |
US20030152909A1 (en) * | 1994-11-16 | 2003-08-14 | Mitrani Eduardo N. | In vitro micro-organs, and uses related thereto |
WO2003035851A1 (en) * | 2001-10-23 | 2003-05-01 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | In vitro micro-organs, and uses related thereto |
US5830460A (en) | 1995-03-13 | 1998-11-03 | University Of South Florida | Sertoli cells as transplantation facilitator for cell transplantation |
US6283951B1 (en) | 1996-10-11 | 2001-09-04 | Transvascular, Inc. | Systems and methods for delivering drugs to selected locations within the body |
US7297331B2 (en) * | 1996-04-03 | 2007-11-20 | The Rogosin Institute | Beads containing restricted cancer cells producing material suppressing cancer cell proliferation |
US6224912B1 (en) | 1996-04-03 | 2001-05-01 | The Rogo Institute | Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment |
IL118376A0 (en) * | 1996-05-22 | 1996-09-12 | Univ Ben Gurion | Polysaccharide sponges for cell culture and transplantation |
FR2753086B1 (en) * | 1996-09-12 | 1999-02-26 | Hospal R & D Int | DEVICE AND METHOD FOR MANUFACTURING A SEGMENTED TUBULAR CAPSULE CONTAINING A BIOLOGICALLY ACTIVE MEDIUM |
US6458574B1 (en) | 1996-09-12 | 2002-10-01 | Transkaryotic Therapies, Inc. | Treatment of a α-galactosidase a deficiency |
US6200589B1 (en) | 1996-09-13 | 2001-03-13 | The University Of Akron | Biological implants of semipermeable amphiphilic membranes |
US6083725A (en) * | 1996-09-13 | 2000-07-04 | Transkaryotic Therapies, Inc. | Tranfected human cells expressing human α-galactosidase A protein |
US9155496B2 (en) | 1997-03-04 | 2015-10-13 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
US7899511B2 (en) | 2004-07-13 | 2011-03-01 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
US6368858B1 (en) * | 1997-07-22 | 2002-04-09 | The General Hospital Corporation | Modulation of multicellular aggregates by pressure from growth in a matrix |
US6368612B1 (en) * | 1997-12-12 | 2002-04-09 | Biohybrid Technologies Llc | Devices for cloaking transplanted cells |
US7687057B2 (en) | 1998-01-09 | 2010-03-30 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | In vitro micro-organs, and uses related thereto |
US6872387B1 (en) | 1998-02-24 | 2005-03-29 | The Regents Of The University Of Michigan | Three-dimensional hydrogel/cell system |
US7691829B2 (en) * | 1998-03-24 | 2010-04-06 | Petito George D | Composition and method for healing tissues |
US20050208114A1 (en) * | 1998-03-24 | 2005-09-22 | Petito George D | Composition and method for healing tissues |
US9066695B2 (en) | 1998-04-30 | 2015-06-30 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US6175752B1 (en) | 1998-04-30 | 2001-01-16 | Therasense, Inc. | Analyte monitoring device and methods of use |
US8688188B2 (en) | 1998-04-30 | 2014-04-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US8346337B2 (en) | 1998-04-30 | 2013-01-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US6949816B2 (en) | 2003-04-21 | 2005-09-27 | Motorola, Inc. | Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same |
US8465425B2 (en) | 1998-04-30 | 2013-06-18 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US8480580B2 (en) | 1998-04-30 | 2013-07-09 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
US8974386B2 (en) | 1998-04-30 | 2015-03-10 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
MXPA00000009A (en) | 1998-06-22 | 2005-09-08 | Autologous Wound Therapy Inc | Enriched platelet wound healant. |
WO2000029206A1 (en) * | 1998-11-13 | 2000-05-25 | Sensor Technologies Inc. | Monodisperse preparations useful with implanted devices |
US6713293B1 (en) | 1999-02-08 | 2004-03-30 | Friedrich Grummt | Encapsulated cells containing an amplified expression vector as a drug delivery device |
US6495161B1 (en) * | 1999-03-09 | 2002-12-17 | Vivorx, Inc. | Cytoprotective biocompatible containment systems for biologically active materials and methods of making same |
US6365385B1 (en) | 1999-03-22 | 2002-04-02 | Duke University | Methods of culturing and encapsulating pancreatic islet cells |
US6303355B1 (en) | 1999-03-22 | 2001-10-16 | Duke University | Method of culturing, cryopreserving and encapsulating pancreatic islet cells |
US20040213768A1 (en) * | 1999-04-30 | 2004-10-28 | Elliott Robert Bartlett | Preparation for biotransplantation and xenotransplantion and uses thereof |
US20090047325A1 (en) * | 1999-04-30 | 2009-02-19 | Neurotrophincell Pty. Limited | Xenotransplant for cns therapy |
ATE468122T1 (en) * | 1999-04-30 | 2010-06-15 | Neurotrophincell Pty Ltd | XENOTRANSPLANT FOR CNS THERAPY |
US20050265977A1 (en) * | 1999-04-30 | 2005-12-01 | Elliott Robert B | Xenotransplant for CNS therapy |
US6558665B1 (en) * | 1999-05-18 | 2003-05-06 | Arch Development Corporation | Encapsulating particles with coatings that conform to size and shape of the particles |
US6471689B1 (en) * | 1999-08-16 | 2002-10-29 | Thomas Jefferson University | Implantable drug delivery catheter system with capillary interface |
CA2385628A1 (en) * | 1999-09-27 | 2001-04-05 | Ammon B. Peck | Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures |
EP1227886B1 (en) * | 1999-10-20 | 2006-08-23 | Gentra Systems Inc. | Mixing and pouring apparatus with rotatable arm and related vessel |
US6365171B1 (en) * | 1999-11-04 | 2002-04-02 | The University Of Akron | Amphiphilic networks, implantable immunoisolatory devices and methods of preparation |
AU780366B2 (en) * | 2000-01-20 | 2005-03-17 | Diatranz Otsuka Limited | Preparation and xenotransplantation of porcine islets |
US20020106346A1 (en) * | 2000-03-06 | 2002-08-08 | Shah Kumarpal A. | Immune modulation with polystyrene sulfonate |
US20030167054A1 (en) * | 2000-05-05 | 2003-09-04 | Lawrence Rosenberg | Device for cell implantation |
US6730016B1 (en) * | 2000-06-12 | 2004-05-04 | Acorn Cardiovascular, Inc. | Cardiac disease treatment and device |
US20050095268A1 (en) * | 2000-06-12 | 2005-05-05 | Acorn Cardiovascular, Inc. | Cardiac wall tension relief with cell loss management |
WO2002032437A1 (en) * | 2000-10-17 | 2002-04-25 | Diatranz Limited | Preparation and xenotransplantation or porcine islets |
US6560471B1 (en) | 2001-01-02 | 2003-05-06 | Therasense, Inc. | Analyte monitoring device and methods of use |
US7232425B2 (en) * | 2001-03-02 | 2007-06-19 | Sorenson Development, Inc. | Apparatus and method for specific interstitial or subcutaneous diffusion and dispersion of medication |
US7252982B2 (en) * | 2001-03-15 | 2007-08-07 | Massachusetts Institute Of Technology | Tissue engineering enhanced by the transfer of a growth factor gene |
US20030073608A1 (en) * | 2001-04-10 | 2003-04-17 | Woolf Nancy J. | Process for treating disease |
CA2388723C (en) * | 2001-06-06 | 2012-10-23 | Becton, Dickinson & Company | Method of providing a substrate with a ready-to-use, uniformly distributed extracellular matrix |
WO2002100335A2 (en) * | 2001-06-08 | 2002-12-19 | Boehringer Ingelheim Pharmaceuticals, Inc. | Methods for improving cell line activity in immunoisolation devices |
US6928751B2 (en) * | 2001-06-12 | 2005-08-16 | Goldfinger Technologies, Llc | Megasonic cleaner and dryer system |
US8815793B2 (en) * | 2001-07-20 | 2014-08-26 | Northwestern University | Polymeric compositions and related methods of use |
US7618937B2 (en) * | 2001-07-20 | 2009-11-17 | Northwestern University | Peptidomimetic polymers for antifouling surfaces |
US7858679B2 (en) * | 2001-07-20 | 2010-12-28 | Northwestern University | Polymeric compositions and related methods of use |
EP1281767A3 (en) | 2001-07-31 | 2003-05-28 | Aladar A. Szalay | Light emitting microorganisms and cells for diagnosis and therapy of tumors |
CN1585627A (en) | 2001-09-14 | 2005-02-23 | 弗朗西斯J·马丁 | Microfabricated nanopore device for sustained release of therapeutic agent |
ATE535601T1 (en) * | 2001-09-28 | 2011-12-15 | Diabcell Pty Ltd | BREEDING OF FOREIGN TRANSPLANTATION MATERIAL IN CULTURE |
WO2003051286A2 (en) * | 2001-11-01 | 2003-06-26 | Regents Of The University Of Minnesota | Hydrogel compositions, devices, and microscale components |
WO2003040686A2 (en) * | 2001-11-05 | 2003-05-15 | Medgenics, Inc. | Dosing and administration of therapeutic micro-organs in living subjects and devices and methods for same |
US8088568B2 (en) | 2001-11-05 | 2012-01-03 | Medgentics, Inc. | Dermal micro-organs, methods and apparatuses for producing and using the same |
US7468242B2 (en) | 2001-11-05 | 2008-12-23 | Medgenics, Inc. | Dermal micro organs, methods and apparatuses for producing and using the same |
US8501396B2 (en) | 2001-11-05 | 2013-08-06 | Medgenics Medical Israel Ltd. | Dermal micro-organs, methods and apparatuses for producing and using the same |
NZ515310A (en) * | 2001-11-07 | 2004-08-27 | Diabcell Pty Ltd | Methods of treatment and delivery modes |
WO2003054146A2 (en) * | 2001-11-14 | 2003-07-03 | Northwestern University | Self-assembly and mineralization of peptide-amphiphile nanofibers |
US20040023413A1 (en) * | 2001-11-26 | 2004-02-05 | Molecular Reflections, Inc. | Microscale immobilization of molecules using a hydrogel and methods of use thereof |
US8364229B2 (en) | 2003-07-25 | 2013-01-29 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
US7828728B2 (en) | 2003-07-25 | 2010-11-09 | Dexcom, Inc. | Analyte sensor |
US9247901B2 (en) | 2003-08-22 | 2016-02-02 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
US9282925B2 (en) | 2002-02-12 | 2016-03-15 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
US7613491B2 (en) | 2002-05-22 | 2009-11-03 | Dexcom, Inc. | Silicone based membranes for use in implantable glucose sensors |
US8260393B2 (en) | 2003-07-25 | 2012-09-04 | Dexcom, Inc. | Systems and methods for replacing signal data artifacts in a glucose sensor data stream |
US8010174B2 (en) | 2003-08-22 | 2011-08-30 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
WO2003070749A2 (en) * | 2002-02-15 | 2003-08-28 | Northwestern University | Self-assembly of peptide-amphiphile nanofibers under physiological conditions |
US20030170278A1 (en) * | 2002-03-11 | 2003-09-11 | Wolf David E. | Microreactor and method of determining a microreactor suitable for a predetermined mammal |
DK1503788T3 (en) | 2002-04-25 | 2011-10-17 | Shire Human Genetic Therapies | Treatment of alpha-galactosidase A deficiency |
US20050008629A1 (en) * | 2002-05-08 | 2005-01-13 | Interpore Orthopaedics, A Delaware Corporation | Encapsulated AGF cells |
AU2003267892A1 (en) * | 2002-05-08 | 2003-11-11 | The Board Of Trustees Of The Leland Stanford Junior University | Nanotube mat with an array of conduits |
US20030228261A1 (en) * | 2002-06-05 | 2003-12-11 | Aladar Szalay | Light emitting microorganisms and cells for diagnosis and therapy of diseases associated with wounded or inflamed tissue |
EP1369491A1 (en) * | 2002-06-05 | 2003-12-10 | Aladar A. Szalay | Light emitting microorganisms and cells for diagnosis and therapy of diseases associated with wounded or inflamed tissue |
AU2003242967A1 (en) * | 2002-07-12 | 2004-02-02 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method and device for inducing biological processes by micro-organs |
US8911831B2 (en) * | 2002-07-19 | 2014-12-16 | Northwestern University | Surface independent, surface-modifying, multifunctional coatings and applications thereof |
US20080171012A1 (en) * | 2007-01-11 | 2008-07-17 | Phillip Messersmith | Fouling Resistant Coatings and Methods of Making Same |
US7163545B2 (en) * | 2002-07-29 | 2007-01-16 | Mayo Foundation For Medical Education And Research | Spinal cord surgical implant |
US7534761B1 (en) | 2002-08-21 | 2009-05-19 | North Western University | Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom |
US20050069572A1 (en) * | 2002-10-09 | 2005-03-31 | Jennifer Elisseeff | Multi-layered polymerizing hydrogels for tissue regeneration |
JP4571776B2 (en) * | 2002-11-05 | 2010-10-27 | Jx日鉱日石エネルギー株式会社 | Lubricating oil composition |
US7554021B2 (en) | 2002-11-12 | 2009-06-30 | Northwestern University | Composition and method for self-assembly and mineralization of peptide amphiphiles |
AU2003298647A1 (en) * | 2002-11-14 | 2004-06-15 | Claussen, Randal, C. | Synthesis and self-assembly of abc triblock bola peptide |
AU2003294541A1 (en) * | 2002-12-24 | 2004-07-22 | An-Go-Gen Inc. | Encapsulated cell for therapy |
KR100486367B1 (en) * | 2003-01-14 | 2005-04-29 | 학교법인연세대학교 | Biodegradable Dual Porous Scaffold Wrapped with Semi-Permeable Membrane and Tissue Cell Culture Using Thereof |
CA2814767C (en) | 2003-01-31 | 2016-03-15 | Mount Sinai School Of Medicine Of New York University | Combination therapy for treating protein deficiency disorders |
WO2004072104A2 (en) | 2003-02-11 | 2004-08-26 | Northwestern University | Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon |
US7459152B2 (en) * | 2003-04-23 | 2008-12-02 | Rush University Medical Center | Erythropoietin administration to improve graft survival |
EP2377403A1 (en) | 2003-05-01 | 2011-10-19 | Medgenics, Inc. | A genetically modified dermal micro-organ expressing factor VIII |
EP1644492B1 (en) | 2003-06-18 | 2009-01-07 | Genelux Corporation | Modified recombinant vaccinia viruses, uses thereof |
CN1791670A (en) * | 2003-06-24 | 2006-06-21 | 戴伯塞尔有限公司 | Porcine pancreatic islet cultured with porcine sertoli cells for xenotransplantation |
US20070173709A1 (en) * | 2005-04-08 | 2007-07-26 | Petisce James R | Membranes for an analyte sensor |
US9763609B2 (en) | 2003-07-25 | 2017-09-19 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
US8423113B2 (en) | 2003-07-25 | 2013-04-16 | Dexcom, Inc. | Systems and methods for processing sensor data |
JP4708342B2 (en) | 2003-07-25 | 2011-06-22 | デックスコム・インコーポレーテッド | Oxygen augmentation membrane system for use in implantable devices |
US7651596B2 (en) | 2005-04-08 | 2010-01-26 | Dexcom, Inc. | Cellulosic-based interference domain for an analyte sensor |
WO2007120442A2 (en) | 2003-07-25 | 2007-10-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US9135402B2 (en) | 2007-12-17 | 2015-09-15 | Dexcom, Inc. | Systems and methods for processing sensor data |
US8060173B2 (en) | 2003-08-01 | 2011-11-15 | Dexcom, Inc. | System and methods for processing analyte sensor data |
US7774145B2 (en) | 2003-08-01 | 2010-08-10 | Dexcom, Inc. | Transcutaneous analyte sensor |
US20080119703A1 (en) | 2006-10-04 | 2008-05-22 | Mark Brister | Analyte sensor |
US7933639B2 (en) | 2003-08-01 | 2011-04-26 | Dexcom, Inc. | System and methods for processing analyte sensor data |
US8761856B2 (en) | 2003-08-01 | 2014-06-24 | Dexcom, Inc. | System and methods for processing analyte sensor data |
US20190357827A1 (en) | 2003-08-01 | 2019-11-28 | Dexcom, Inc. | Analyte sensor |
US7519408B2 (en) | 2003-11-19 | 2009-04-14 | Dexcom, Inc. | Integrated receiver for continuous analyte sensor |
US8160669B2 (en) | 2003-08-01 | 2012-04-17 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8369919B2 (en) | 2003-08-01 | 2013-02-05 | Dexcom, Inc. | Systems and methods for processing sensor data |
US8622905B2 (en) | 2003-08-01 | 2014-01-07 | Dexcom, Inc. | System and methods for processing analyte sensor data |
US8275437B2 (en) | 2003-08-01 | 2012-09-25 | Dexcom, Inc. | Transcutaneous analyte sensor |
US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
US8845536B2 (en) | 2003-08-01 | 2014-09-30 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8886273B2 (en) | 2003-08-01 | 2014-11-11 | Dexcom, Inc. | Analyte sensor |
US20140121989A1 (en) | 2003-08-22 | 2014-05-01 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
US8233959B2 (en) | 2003-08-22 | 2012-07-31 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
SE526959C2 (en) * | 2003-10-02 | 2005-11-29 | Tikomed Ab | Bioartificial implant comprising a semipermeable barrier and a method for reducing the risk of connective tissue formation in the implant after implantation by providing the barrier with a permeable coating of bioactive metal |
US8916184B2 (en) * | 2003-11-07 | 2014-12-23 | University Of Connecticut | Artificial tissue systems and uses thereof |
US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
US8615282B2 (en) | 2004-07-13 | 2013-12-24 | Dexcom, Inc. | Analyte sensor |
WO2005056576A2 (en) | 2003-12-05 | 2005-06-23 | Northwestern University | Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof |
US8364231B2 (en) | 2006-10-04 | 2013-01-29 | Dexcom, Inc. | Analyte sensor |
US11633133B2 (en) | 2003-12-05 | 2023-04-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US8423114B2 (en) | 2006-10-04 | 2013-04-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
CN102225964A (en) * | 2003-12-05 | 2011-10-26 | 西北大学 | Self-assembling peptide amphiphiles and related methods for growth factor delivery |
EP1711790B1 (en) | 2003-12-05 | 2010-09-08 | DexCom, Inc. | Calibration techniques for a continuous analyte sensor |
US8287453B2 (en) | 2003-12-05 | 2012-10-16 | Dexcom, Inc. | Analyte sensor |
EP2316331B1 (en) | 2003-12-09 | 2016-06-29 | Dexcom, Inc. | Signal processing for continuous analyte sensor |
AU2011204947B2 (en) * | 2003-12-15 | 2013-05-09 | Ethicon Endo-Surgery, Inc. | Method and device for minimally invasive implantation of biomaterial |
US7780973B2 (en) * | 2003-12-15 | 2010-08-24 | Ethicon Endo-Surgery, Inc. | Method and device for minimally invasive implantation of biomaterial |
WO2005079257A2 (en) * | 2004-02-12 | 2005-09-01 | Dexcom, Inc. | Biointerface with macro- and micro- architecture |
US8808228B2 (en) | 2004-02-26 | 2014-08-19 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
EP1737949B1 (en) * | 2004-03-09 | 2010-09-15 | Absorber AB | Endothelial progenitor cells and methods of use thereof |
US20050208090A1 (en) * | 2004-03-18 | 2005-09-22 | Medtronic, Inc. | Methods and systems for treatment of neurological diseases of the central nervous system |
US8792955B2 (en) | 2004-05-03 | 2014-07-29 | Dexcom, Inc. | Transcutaneous analyte sensor |
JP2008503590A (en) * | 2004-06-21 | 2008-02-07 | メドトロニック・インコーポレーテッド | Medical systems and methods for delivering compositions to cells |
US8565848B2 (en) | 2004-07-13 | 2013-10-22 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8452368B2 (en) | 2004-07-13 | 2013-05-28 | Dexcom, Inc. | Transcutaneous analyte sensor |
US20060016700A1 (en) | 2004-07-13 | 2006-01-26 | Dexcom, Inc. | Transcutaneous analyte sensor |
US7783333B2 (en) | 2004-07-13 | 2010-08-24 | Dexcom, Inc. | Transcutaneous medical device with variable stiffness |
WO2006127694A2 (en) | 2004-07-13 | 2006-11-30 | Dexcom, Inc. | Analyte sensor |
US7654956B2 (en) | 2004-07-13 | 2010-02-02 | Dexcom, Inc. | Transcutaneous analyte sensor |
US7910359B2 (en) * | 2004-07-29 | 2011-03-22 | University Of Miami | Hybrid device for cell therapies |
AU2005325213B2 (en) | 2004-08-04 | 2010-10-07 | Evonik Corporation | Methods for manufacturing delivery devices and devices thereof |
US8075904B2 (en) * | 2004-08-11 | 2011-12-13 | California Institute Of Technology | High aspect ratio template and method for producing same for central and peripheral nerve repair |
US20060046960A1 (en) * | 2004-09-02 | 2006-03-02 | Mckay William F | Controlled and directed local delivery of anti-inflammatory compositions |
US20060046961A1 (en) * | 2004-09-02 | 2006-03-02 | Mckay William F | Controlled and directed local delivery of anti-inflammatory compositions |
US20060093639A1 (en) * | 2004-10-29 | 2006-05-04 | Starkebaum Warren L | Method and device for destroying body tissue |
US20070009668A1 (en) * | 2004-11-18 | 2007-01-11 | Wyman Jason L | Microencapsulation of particles in a polymer solution by selective withdrawal through a high viscosity low density fluid and subsequent crosslinking |
GB2420976B (en) * | 2004-11-19 | 2006-12-20 | Zvi Finkelstein | Therapeutic implant |
US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
MX2007008826A (en) * | 2005-01-21 | 2007-11-15 | Univ Northwestern | Methods and compositions for encapsulation of cells. |
KR20070108555A (en) * | 2005-03-04 | 2007-11-12 | 노오쓰웨스턴 유니버시티 | Angiogenic heparin binding peptide amphiphiles |
US8133178B2 (en) | 2006-02-22 | 2012-03-13 | Dexcom, Inc. | Analyte sensor |
US20090076360A1 (en) | 2007-09-13 | 2009-03-19 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8744546B2 (en) | 2005-05-05 | 2014-06-03 | Dexcom, Inc. | Cellulosic-based resistance domain for an analyte sensor |
US20060249381A1 (en) * | 2005-05-05 | 2006-11-09 | Petisce James R | Cellulosic-based resistance domain for an analyte sensor |
US20090075375A1 (en) * | 2005-04-18 | 2009-03-19 | Neurotrophincell Pty Limited | Choroid plexus preparation and uses thereof |
NZ536009A (en) | 2005-04-18 | 2007-01-26 | Neurotrophincell Pty Ltd | Choroid plexus preparation and uses thereof |
US7588775B2 (en) * | 2005-04-23 | 2009-09-15 | E-L Management Corp. | Silicone elastomer exfoliating compositions |
KR20080025373A (en) | 2005-05-17 | 2008-03-20 | 아미쿠스 세라퓨틱스, 인코포레이티드 | A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives |
NZ540597A (en) * | 2005-06-08 | 2007-02-23 | Neurotrophincell Pty Ltd | A method for preventing the onset of type I diabetes comprising administering an implantable composition comprising living choroid plexus cells |
US7616111B2 (en) | 2005-06-20 | 2009-11-10 | Carestream Health, Inc. | System to monitor the ingestion of medicines |
US7782189B2 (en) * | 2005-06-20 | 2010-08-24 | Carestream Health, Inc. | System to monitor the ingestion of medicines |
WO2007016643A2 (en) * | 2005-08-01 | 2007-02-08 | Mount Sinai School Of Medicine Of New York University | A method for extending longevity using npc1l1 antagonists |
CN101437571B (en) | 2005-10-13 | 2013-01-02 | 斯恩蒂斯有限公司 | Drug-impregnated encasement |
US20070190165A1 (en) * | 2005-10-21 | 2007-08-16 | Brey Eric M | Tissue-specific basement membrane gels |
US20070116680A1 (en) * | 2005-11-18 | 2007-05-24 | Rensselaer Polytechnic Institute | Stem cells within gel microenvironments |
US20070190036A1 (en) * | 2006-01-04 | 2007-08-16 | Seda Kizilel | Microencapsulation of pancreatic islets within a thin coat of glucagon-like peptide-1 functionalized poly(ethylene glycol) |
US9757061B2 (en) | 2006-01-17 | 2017-09-12 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
US7732539B2 (en) * | 2006-02-16 | 2010-06-08 | National Science Foundation | Modified acrylic block copolymers for hydrogels and pressure sensitive wet adhesives |
US20100056440A1 (en) * | 2006-03-01 | 2010-03-04 | Biogen Idec Ma Inc. | Compositions and methods for administering gdnf ligand family proteins |
US7920907B2 (en) | 2006-06-07 | 2011-04-05 | Abbott Diabetes Care Inc. | Analyte monitoring system and method |
TW200819540A (en) | 2006-07-11 | 2008-05-01 | Genelux Corp | Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders |
JP5597836B2 (en) | 2006-08-04 | 2014-10-01 | ケンジー ナッシュ コーポレイション | Biomimetic compound and synthesis method thereof |
US8563117B2 (en) * | 2006-08-04 | 2013-10-22 | Phillip B. Messersmith | Biomimetic modular adhesive complex: materials, methods and applications therefore |
AU2007287201B2 (en) | 2006-08-23 | 2012-11-15 | Svip 2 Llc | Devices and methods for altering eating behavior |
CN101528166B (en) * | 2006-08-29 | 2014-05-07 | 阿克伦大学 | Implantable devices for producing insulin |
US8454948B2 (en) | 2006-09-14 | 2013-06-04 | Medgenics Medical Israel Ltd. | Long lasting drug formulations |
WO2008062417A2 (en) * | 2006-11-22 | 2008-05-29 | Beta O2 Technologies Ltd. | Protecting algae from body fluids |
US7980000B2 (en) | 2006-12-29 | 2011-07-19 | Applied Materials, Inc. | Vapor dryer having hydrophilic end effector |
US8673286B2 (en) | 2007-04-09 | 2014-03-18 | Northwestern University | DOPA-functionalized, branched, poly(aklylene oxide) adhesives |
US8383092B2 (en) * | 2007-02-16 | 2013-02-26 | Knc Ner Acquisition Sub, Inc. | Bioadhesive constructs |
US8076295B2 (en) * | 2007-04-17 | 2011-12-13 | Nanotope, Inc. | Peptide amphiphiles having improved solubility and methods of using same |
US20200037874A1 (en) | 2007-05-18 | 2020-02-06 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
WO2008149347A2 (en) * | 2007-06-04 | 2008-12-11 | Svip 8 Llc | Tissue anchorable devices |
WO2009110917A1 (en) * | 2007-06-07 | 2009-09-11 | Osteotherapeutics, L.L.C. | Bone cement compositions for use as growth factor carriers and methods of making same |
US20080306434A1 (en) | 2007-06-08 | 2008-12-11 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
AU2008266060B2 (en) * | 2007-06-13 | 2013-08-29 | Fmc Corporation | Alginate coated, polysaccharide gel-containing foam composite, preparative methods, and uses thereof |
US20090004455A1 (en) * | 2007-06-27 | 2009-01-01 | Philippe Gravagna | Reinforced composite implant |
US8932619B2 (en) * | 2007-06-27 | 2015-01-13 | Sofradim Production | Dural repair material |
EP2205634A2 (en) * | 2007-08-08 | 2010-07-14 | Biogen Idec MA, Inc. | Anti-neublastin antibodies and uses thereof |
MX2010001993A (en) | 2007-08-23 | 2010-03-11 | Intrexon Corp | Methods and compositions for diagnosing disease. |
US20090068250A1 (en) | 2007-09-07 | 2009-03-12 | Philippe Gravagna | Bioresorbable and biocompatible compounds for surgical use |
US8093038B2 (en) * | 2007-09-17 | 2012-01-10 | Illinois Institute Of Technology | Apparatus and method for encapsulating pancreatic cells |
US20100278798A1 (en) * | 2007-09-27 | 2010-11-04 | The Trustees Of Columbia University In The City Of New York | Methods and systems for forming biocompatible materials |
EP2205249B1 (en) | 2007-09-28 | 2018-11-07 | Intrexon Corporation | Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof |
US20090090214A1 (en) * | 2007-10-04 | 2009-04-09 | Chung Yuan Christian University | Method for forming nano-scale metal particles |
US9452258B2 (en) | 2007-10-09 | 2016-09-27 | Dexcom, Inc. | Integrated insulin delivery system with continuous glucose sensor |
US8417312B2 (en) | 2007-10-25 | 2013-04-09 | Dexcom, Inc. | Systems and methods for processing sensor data |
US9308068B2 (en) * | 2007-12-03 | 2016-04-12 | Sofradim Production | Implant for parastomal hernia |
US8290559B2 (en) | 2007-12-17 | 2012-10-16 | Dexcom, Inc. | Systems and methods for processing sensor data |
WO2009079555A2 (en) * | 2007-12-17 | 2009-06-25 | Anna Love | Soft tissue filler |
ES2718612T3 (en) | 2007-12-20 | 2019-07-03 | Evonik Corp | Procedure for preparing microparticles that have a low volume of residual solvent |
WO2009086535A2 (en) * | 2007-12-27 | 2009-07-09 | The Trustees Of Columbia University In The City Of New York | Systems and methods for forming patterned extracellular matrix materials |
CA2715628A1 (en) | 2008-02-21 | 2009-08-27 | Dexcom, Inc. | Systems and methods for processing, transmitting and displaying sensor data |
US8396528B2 (en) | 2008-03-25 | 2013-03-12 | Dexcom, Inc. | Analyte sensor |
US8583204B2 (en) | 2008-03-28 | 2013-11-12 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
US20090247856A1 (en) | 2008-03-28 | 2009-10-01 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
US11730407B2 (en) | 2008-03-28 | 2023-08-22 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
US8682408B2 (en) | 2008-03-28 | 2014-03-25 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
CA2726804C (en) | 2008-06-02 | 2021-12-28 | Dana-Farber Cancer Institute, Inc. | Xbp1, cd138, and cs1 peptides |
EP2303390A4 (en) * | 2008-06-03 | 2011-11-30 | Svip 8 Llc | Tissue-anchored devices |
US9242026B2 (en) * | 2008-06-27 | 2016-01-26 | Sofradim Production | Biosynthetic implant for soft tissue repair |
WO2010019788A1 (en) * | 2008-08-13 | 2010-02-18 | Smed-Ta/Td. Llc | Drug delivery implants |
US10842645B2 (en) | 2008-08-13 | 2020-11-24 | Smed-Ta/Td, Llc | Orthopaedic implant with porous structural member |
CA2734183C (en) * | 2008-08-13 | 2016-11-01 | Smed-Ta/Td, Llc | Orthopaedic implant with spatially varying porosity |
US20100042213A1 (en) * | 2008-08-13 | 2010-02-18 | Nebosky Paul S | Drug delivery implants |
US9700431B2 (en) | 2008-08-13 | 2017-07-11 | Smed-Ta/Td, Llc | Orthopaedic implant with porous structural member |
US9616205B2 (en) | 2008-08-13 | 2017-04-11 | Smed-Ta/Td, Llc | Drug delivery implants |
JP5687622B2 (en) * | 2008-08-29 | 2015-03-18 | スメド−ティーエイ/ティーディー・エルエルシー | Orthopedic implant |
WO2010033724A2 (en) | 2008-09-19 | 2010-03-25 | Dexcom, Inc. | Particle-containing membrane and particulate electrode for analyte sensors |
EP2410910A4 (en) | 2009-03-27 | 2014-10-15 | Dexcom Inc | Methods and systems for promoting glucose management |
CN102625661B (en) | 2009-04-09 | 2015-05-27 | 阿米库斯治疗学公司 | Methods for preventing and/or treating lysosomal storage disorders |
KR20120012811A (en) * | 2009-04-13 | 2012-02-10 | 노오쓰웨스턴 유니버시티 | Novel peptide-based scaffolds for cartilage regeneration and methods for their use |
JP5850416B2 (en) * | 2009-06-19 | 2016-02-03 | 国立大学法人九州大学 | Method for producing cell tissue |
FR2949688B1 (en) | 2009-09-04 | 2012-08-24 | Sofradim Production | FABRIC WITH PICOTS COATED WITH A BIORESORBABLE MICROPOROUS LAYER |
US8858990B2 (en) * | 2009-09-17 | 2014-10-14 | The Ohio State University | Capsule of thermogenic cells for treating a metabolic disease |
BR112012006443A2 (en) * | 2009-09-22 | 2017-07-25 | Evonik Degussa Corp | implant devices that feature variable loading configurations of bioactive agents |
US20110091427A1 (en) * | 2009-10-02 | 2011-04-21 | Baxter International Inc. | Methods for treating a kidney injury |
JP5805649B2 (en) | 2009-10-19 | 2015-11-04 | アミカス セラピューティックス インコーポレイテッド | Novel composition for preventing and / or treating degenerative disorders of the central nervous system |
RU2016103139A (en) | 2009-10-19 | 2018-11-22 | Амикус Терапьютикс, Инк. | NEW COMPOSITIONS FOR PREVENTING AND / OR TREATING LYSOSOMAL ACCUMULATION DISEASES |
US20110106062A1 (en) * | 2009-11-05 | 2011-05-05 | Ecole Polytechnique Federale De Lausanne | System and Method For In Vivo Delivery of Antibodies and Fragments Thereof |
US20110130465A1 (en) * | 2009-12-01 | 2011-06-02 | Nerites Corporation | Coatings for prevention of biofilms |
WO2011079222A2 (en) * | 2009-12-23 | 2011-06-30 | Boston Scientific Scimed, Inc. | Less traumatic method of delivery of mesh-based devices into human body |
US8592364B2 (en) * | 2010-02-11 | 2013-11-26 | Ecole Polytechnique Federale de Lausanne (“EPFL”) | CCR7 ligand delivery and co-delivery in immunotherapy |
JP5988961B2 (en) | 2010-04-28 | 2016-09-07 | ザ ジェイ. デヴィッド グラッドストーン インスティテューツ | Methods for generating cardiomyocytes |
JP2013532144A (en) | 2010-06-14 | 2013-08-15 | ハー・ルンドベック・アクチエゼルスカベット | Regulation of the interaction between SorLA and GDNF family ligand receptors |
ES2685171T3 (en) | 2010-06-14 | 2018-10-05 | The Scripps Research Institute | Reprogramming cells to a new destination |
KR101591887B1 (en) | 2010-06-15 | 2016-02-04 | 메드제닉스 메디칼 이스라엘 리미티드 | Long lasting drug formulations |
WO2012009377A2 (en) | 2010-07-12 | 2012-01-19 | University Of Southern California | Biocompatible substrate for facilitating interconnections between stem cells and target tissues and methods for implanting same |
US9475709B2 (en) | 2010-08-25 | 2016-10-25 | Lockheed Martin Corporation | Perforated graphene deionization or desalination |
EP2637707A4 (en) | 2010-11-09 | 2014-10-01 | Kensey Nash Corp | Adhesive compounds and methods use for hernia repair |
BRPI1008258B1 (en) * | 2010-12-16 | 2020-03-17 | Cellprotect Biotecnologia Ltda - Me | BIOPOLIMERIC COMPOSITION FOR CELL ENCAPSULATION, METHOD OF PRODUCTION OF A BIOPOLIMERIC COMPOSITION FOR CELL ENCAPSULATION, METHOD FOR PROMOTING THE CYTOPROTECTION OF CELLS AND THE USE OF A BIOPOLULULIC COMPOSITION |
US8360765B2 (en) | 2011-01-07 | 2013-01-29 | Covidien Lp | Systems and method for forming a coaxial implant |
FR2972626B1 (en) | 2011-03-16 | 2014-04-11 | Sofradim Production | PROSTHETIC COMPRISING A THREE-DIMENSIONAL KNIT AND ADJUSTED |
ES2847578T3 (en) | 2011-04-15 | 2021-08-03 | Dexcom Inc | Advanced analyte sensor calibration and error detection |
US8877489B2 (en) | 2011-12-05 | 2014-11-04 | California Institute Of Technology | Ultrathin parylene-C semipermeable membranes for biomedical applications |
US10478206B2 (en) | 2011-04-29 | 2019-11-19 | University Of Southern California | Instruments and methods for the implantation of cell-seeded substrates |
FR2977790B1 (en) | 2011-07-13 | 2013-07-19 | Sofradim Production | PROSTHETIC FOR UMBILIC HERNIA |
FR2977789B1 (en) | 2011-07-13 | 2013-07-19 | Sofradim Production | PROSTHETIC FOR UMBILIC HERNIA |
EP2747650B1 (en) | 2011-08-26 | 2023-04-05 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
CA2849052C (en) | 2011-09-30 | 2019-11-05 | Sofradim Production | Reversible stiffening of light weight mesh |
EP2760431A1 (en) | 2011-09-30 | 2014-08-06 | Sofradim Production | Multilayer implants for delivery of therapeutic agents |
US20130096170A1 (en) | 2011-10-14 | 2013-04-18 | Hospira, Inc. | Methods of treating pediatric patients using dexmedetomidine |
CN104321069A (en) | 2011-10-27 | 2015-01-28 | 威尔斯达眼科制剂公司 | Vectors encoding rod-derived cone viability factor |
US9248013B2 (en) | 2011-12-05 | 2016-02-02 | California Institute Of Technology | 3-Dimensional parylene scaffold cage |
TWI590843B (en) | 2011-12-28 | 2017-07-11 | 信迪思有限公司 | Films and methods of manufacture |
FR2985170B1 (en) | 2011-12-29 | 2014-01-24 | Sofradim Production | PROSTHESIS FOR INGUINAL HERNIA |
FR2985271B1 (en) | 2011-12-29 | 2014-01-24 | Sofradim Production | KNITTED PICOTS |
US8242158B1 (en) | 2012-01-04 | 2012-08-14 | Hospira, Inc. | Dexmedetomidine premix formulation |
WO2013126590A2 (en) | 2012-02-21 | 2013-08-29 | Baxter International Inc. | Pharmaceutical composition comprising cd34+ cells |
MX354127B (en) | 2012-03-27 | 2018-02-14 | Amicus Therapeutics Inc | Novel compounds for preventing and/or treating lysosomal storage disorders and/or degenerative disorders of the central nervous system. |
US10376845B2 (en) | 2016-04-14 | 2019-08-13 | Lockheed Martin Corporation | Membranes with tunable selectivity |
US9834809B2 (en) | 2014-02-28 | 2017-12-05 | Lockheed Martin Corporation | Syringe for obtaining nano-sized materials for selective assays and related methods of use |
US10980919B2 (en) | 2016-04-14 | 2021-04-20 | Lockheed Martin Corporation | Methods for in vivo and in vitro use of graphene and other two-dimensional materials |
US10653824B2 (en) | 2012-05-25 | 2020-05-19 | Lockheed Martin Corporation | Two-dimensional materials and uses thereof |
US9744617B2 (en) | 2014-01-31 | 2017-08-29 | Lockheed Martin Corporation | Methods for perforating multi-layer graphene through ion bombardment |
US9289453B2 (en) * | 2012-06-14 | 2016-03-22 | Ramot At Tel-Aviv University Ltd. | Transplantation of cells into the nasal cavity and the subarachnoid cranial space |
FR2994185B1 (en) | 2012-08-02 | 2015-07-31 | Sofradim Production | PROCESS FOR THE PREPARATION OF A POROUS CHITOSAN LAYER |
FR2995778B1 (en) | 2012-09-25 | 2015-06-26 | Sofradim Production | ABDOMINAL WALL REINFORCING PROSTHESIS AND METHOD FOR MANUFACTURING THE SAME |
FR2995779B1 (en) | 2012-09-25 | 2015-09-25 | Sofradim Production | PROSTHETIC COMPRISING A TREILLIS AND A MEANS OF CONSOLIDATION |
FR2995788B1 (en) | 2012-09-25 | 2014-09-26 | Sofradim Production | HEMOSTATIC PATCH AND PREPARATION METHOD |
US10159555B2 (en) | 2012-09-28 | 2018-12-25 | Sofradim Production | Packaging for a hernia repair device |
US9788765B2 (en) | 2012-09-28 | 2017-10-17 | Dexcom, Inc. | Zwitterion surface modifications for continuous sensors |
CN105377288B (en) | 2012-11-05 | 2019-11-15 | 达纳-法伯癌症研究所股份有限公司 | The composition of XBP1, CD138 and CS1 peptide prepares the purposes of drug |
EP2934555B1 (en) | 2012-12-21 | 2021-09-22 | Astellas Institute for Regenerative Medicine | Methods for production of platelets from pluripotent stem cells |
TW201504140A (en) | 2013-03-12 | 2015-02-01 | Lockheed Corp | Method for forming perforated graphene with uniform aperture size |
US10130288B2 (en) | 2013-03-14 | 2018-11-20 | Cell and Molecular Tissue Engineering, LLC | Coated sensors, and corresponding systems and methods |
US10405961B2 (en) | 2013-03-14 | 2019-09-10 | Cell and Molecular Tissue Engineering, LLC | Coated surgical mesh, and corresponding systems and methods |
US10172791B2 (en) * | 2013-03-14 | 2019-01-08 | Massachusetts Institute Of Technology | Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates |
US10376562B2 (en) | 2013-03-15 | 2019-08-13 | The Jackson Laboratory | Methods for promoting wound healing and hair growth comprising GDNF administration |
DE102013004595A1 (en) | 2013-03-15 | 2014-09-18 | Emergent Product Development Germany Gmbh | RSV vaccines |
FR3006578B1 (en) | 2013-06-07 | 2015-05-29 | Sofradim Production | PROSTHESIS BASED ON TEXTILE FOR LAPAROSCOPIC PATHWAY |
FR3006581B1 (en) | 2013-06-07 | 2016-07-22 | Sofradim Production | PROSTHESIS BASED ON TEXTILE FOR LAPAROSCOPIC PATHWAY |
CA2916249C (en) | 2013-06-21 | 2021-07-13 | DePuy Synthes Products, Inc. | Films and methods of manufacture |
US9572918B2 (en) | 2013-06-21 | 2017-02-21 | Lockheed Martin Corporation | Graphene-based filter for isolating a substance from blood |
CN105940479A (en) | 2014-01-31 | 2016-09-14 | 洛克希德马丁公司 | Methods for perforating two-dimensional materials using a broad ion field |
CA2938305A1 (en) | 2014-01-31 | 2015-08-06 | Lockheed Martin Corporation | Processes for forming composite structures with a two-dimensional material using a porous, non-sacrificial supporting layer |
WO2015123385A1 (en) | 2014-02-12 | 2015-08-20 | Amicus Therapeutics, Inc. | Sugar derivatives comprising sulfur-containing moieties and methods of making same and methods of using the same for the treatment of mps iiic |
JP2017512129A (en) | 2014-03-12 | 2017-05-18 | ロッキード・マーチン・コーポレーション | Separation membranes formed from perforated graphene |
US9675627B2 (en) | 2014-04-14 | 2017-06-13 | Amicus Therapeutics, Inc. | Dosing regimens for treating and/or preventing cerebral amyloidoses |
WO2015159889A1 (en) * | 2014-04-14 | 2015-10-22 | 学校法人福岡大学 | Method for transplanting insulin-producing cells |
JP6817194B2 (en) * | 2014-05-12 | 2021-01-20 | ルースタービオ インコーポレイテッド | Instantly printable cells and integrated devices |
DK3166550T3 (en) * | 2014-07-11 | 2024-01-29 | Us Health | Surgical tool for ocular tissue transplantation |
US10080877B2 (en) | 2014-07-25 | 2018-09-25 | Warsaw Orthopedic, Inc. | Drug delivery device and methods having a drug cartridge |
EP3172570A4 (en) | 2014-07-25 | 2017-12-27 | Becton, Dickinson and Company | Analyte test strip assays, and test strips and kits for use in practicing the same |
US9775978B2 (en) | 2014-07-25 | 2017-10-03 | Warsaw Orthopedic, Inc. | Drug delivery device and methods having a retaining member |
EP3188823A4 (en) | 2014-09-02 | 2018-04-25 | Lockheed Martin Corporation | Hemodialysis and hemofiltration membranes based upon a two-dimensional membrane material and methods employing same |
EP3000489B1 (en) | 2014-09-24 | 2017-04-05 | Sofradim Production | Method for preparing an anti-adhesion barrier film |
EP3000432B1 (en) | 2014-09-29 | 2022-05-04 | Sofradim Production | Textile-based prosthesis for treatment of inguinal hernia |
EP3000433B1 (en) | 2014-09-29 | 2022-09-21 | Sofradim Production | Device for introducing a prosthesis for hernia treatment into an incision and flexible textile based prosthesis |
EP3029189B1 (en) | 2014-12-05 | 2021-08-11 | Sofradim Production | Prosthetic porous knit, method of making same and hernia prosthesis |
US9238090B1 (en) | 2014-12-24 | 2016-01-19 | Fettech, Llc | Tissue-based compositions |
EP3059255B1 (en) | 2015-02-17 | 2020-05-13 | Sofradim Production | Method for preparing a chitosan-based matrix comprising a fiber reinforcement member |
EP3085337B1 (en) | 2015-04-24 | 2022-09-14 | Sofradim Production | Prosthesis for supporting a breast structure |
EP3106185B1 (en) | 2015-06-19 | 2018-04-25 | Sofradim Production | Synthetic prosthesis comprising a knit and a non porous film and method for forming same |
AU2016303048A1 (en) | 2015-08-05 | 2018-03-01 | Lockheed Martin Corporation | Perforatable sheets of graphene-based material |
AU2016303049A1 (en) | 2015-08-06 | 2018-03-01 | Lockheed Martin Corporation | Nanoparticle modification and perforation of graphene |
US10179128B2 (en) | 2015-08-31 | 2019-01-15 | Amicus Therapeutics, Inc. | Regimens for treating and preventing lysosomal disorders and degenerative disorders of the central nervous system |
JP6895674B2 (en) * | 2015-10-21 | 2021-06-30 | 国立大学法人 東京大学 | Microtubes, microtube manufacturing methods, and microtube manufacturing equipment |
US10076650B2 (en) | 2015-11-23 | 2018-09-18 | Warsaw Orthopedic, Inc. | Enhanced stylet for drug depot injector |
EP3397397B1 (en) | 2015-12-30 | 2021-02-17 | DexCom, Inc. | Enzyme immobilized adhesive layer for analyte sensors |
EP3195830B1 (en) | 2016-01-25 | 2020-11-18 | Sofradim Production | Prosthesis for hernia repair |
JP2019521055A (en) | 2016-04-14 | 2019-07-25 | ロッキード・マーチン・コーポレーション | Selective interface relaxation of graphene defects |
EP3443329A4 (en) | 2016-04-14 | 2020-04-08 | Lockheed Martin Corporation | Methods for in situ monitoring and control of defect formation or healing |
CA3020686A1 (en) | 2016-04-14 | 2017-10-19 | Lockheed Martin Corporation | Method for treating graphene sheets for large-scale transfer using free-float method |
EP3442786A4 (en) | 2016-04-14 | 2020-03-18 | Lockheed Martin Corporation | Two-dimensional membrane structures having flow passages |
USD802756S1 (en) | 2016-06-23 | 2017-11-14 | Warsaw Orthopedic, Inc. | Drug pellet cartridge |
NL2017294B1 (en) | 2016-08-05 | 2018-02-14 | Univ Erasmus Med Ct Rotterdam | Natural cryptic exon removal by pairs of antisense oligonucleotides. |
US20190209669A1 (en) | 2016-08-23 | 2019-07-11 | Oncopep, Inc. | Peptide vaccines and durvalumab for treating breast cancer |
WO2018039203A1 (en) | 2016-08-23 | 2018-03-01 | Oncopep, Inc. | Peptide vaccines and durvalumab for treating multiple myeloma |
EP3312325B1 (en) | 2016-10-21 | 2021-09-22 | Sofradim Production | Method for forming a mesh having a barbed suture attached thereto and the mesh thus obtained |
US10434261B2 (en) | 2016-11-08 | 2019-10-08 | Warsaw Orthopedic, Inc. | Drug pellet delivery system and method |
EP3539574A4 (en) * | 2016-11-11 | 2019-11-13 | FUJIFILM Corporation | Immunoisolation membrane, transplantation chamber, and transplantation device |
WO2018088452A1 (en) | 2016-11-11 | 2018-05-17 | 富士フイルム株式会社 | Immunoisolation membrane, transplantation chamber, and transplantation device |
KR20240031326A (en) | 2016-12-31 | 2024-03-07 | 바이오엑셀 테라퓨틱스 인코포레이티드 | Use of Sublingual Dexmedetomidine for the treatment of Agitation |
KR20190134807A (en) | 2017-04-25 | 2019-12-04 | 아미쿠스 세라퓨틱스, 인코포레이티드 | Novel compositions for preventing and / or treating degenerative diseases and / or lysosomal reservoirs of the central nervous system |
EP3398554A1 (en) | 2017-05-02 | 2018-11-07 | Sofradim Production | Prosthesis for inguinal hernia repair |
JP6790267B2 (en) | 2017-06-29 | 2020-11-25 | 富士フイルム株式会社 | Transplant chambers and devices |
CN110831636B (en) | 2017-06-29 | 2022-06-28 | 富士胶片株式会社 | Transplantation chamber, transplantation chamber manufacturing method, transplantation device, and porous membrane welding method |
CN110831637B (en) | 2017-06-29 | 2022-03-18 | 富士胶片株式会社 | Transplantation chamber and transplantation device |
US10744313B2 (en) | 2017-07-27 | 2020-08-18 | University Of Utah Research Foundation | Therapeutic delivery device |
EP3675897A1 (en) | 2017-09-01 | 2020-07-08 | Dana Farber Cancer Institute, Inc. | Immunogenic peptides specific to bcma and taci antigens for treatment of cancer |
US11331022B2 (en) | 2017-10-24 | 2022-05-17 | Dexcom, Inc. | Pre-connected analyte sensors |
CN111246797A (en) | 2017-10-24 | 2020-06-05 | 德克斯康公司 | Pre-attached analyte sensors |
WO2019083960A1 (en) | 2017-10-24 | 2019-05-02 | Oncopep, Inc. | Peptide vaccines and hdac inhibitors for treating multiple myeloma |
US20200276304A1 (en) | 2017-10-24 | 2020-09-03 | Oncopep, Inc. | Peptide vaccines and pembrolizumab for treating breast cancer |
CA3103431A1 (en) | 2018-06-27 | 2020-01-02 | Bioxcel Therapeutics, Inc. | Film formulations containing dexmedetomidine and methods of producing them |
US11160791B2 (en) | 2018-11-01 | 2021-11-02 | Medefil, Inc. | Dexmedetomidine injection premix formulation in ready to use (RTU) bags |
EP3653171A1 (en) | 2018-11-16 | 2020-05-20 | Sofradim Production | Implants suitable for soft tissue repair |
JP6601931B1 (en) * | 2019-07-17 | 2019-11-06 | 株式会社セルファイバ | Cell fiber manufacturing system, cell fiber manufacturing method and program |
CA3145388A1 (en) | 2019-07-19 | 2021-01-28 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
US11260146B2 (en) | 2019-11-27 | 2022-03-01 | Terumo Medical Corporation | Seal-healing valve for a medical instrument |
EP4307999A1 (en) | 2021-03-19 | 2024-01-24 | Dexcom, Inc. | Drug releasing membrane for analyte sensor |
KR20240006581A (en) | 2021-05-06 | 2024-01-15 | 호바 세라퓨틱스 에이피에스 | Prevention and treatment of chemotherapy-induced neuropathic pain |
WO2022240741A1 (en) | 2021-05-12 | 2022-11-17 | Dana-Farber Cancer Institute, Inc. | Lag3 and gal3 inhibitory agents, xbp1, cs1, and cd138 peptides, and methods of use thereof |
WO2023043908A1 (en) | 2021-09-15 | 2023-03-23 | Dexcom, Inc. | Bioactive releasing membrane for analyte sensor |
WO2023104960A1 (en) | 2021-12-10 | 2023-06-15 | Hoba Therapeutics Aps | Treatment of nociceptive pain |
CA3228457A1 (en) | 2022-02-02 | 2023-08-10 | Dexcom, Inc. | Sensing systems and methods for diagnosing, staging, treating, and assessing risks of liver disease using monitored analyte data |
US20230263434A1 (en) | 2022-02-23 | 2023-08-24 | Dexcom, Inc. | Sensing systems and methods for providing decision support around kidney health and/or diabetes |
US20230389833A1 (en) | 2022-06-01 | 2023-12-07 | Dexcom, Inc. | Systems and methods for monitoring, diagnosis, and decision support for diabetes in patients with kidney disease |
WO2024050126A2 (en) | 2022-09-02 | 2024-03-07 | Dexcom, Inc. | Continuous analyte sensor devices and methods |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4353888A (en) * | 1980-12-23 | 1982-10-12 | Sefton Michael V | Encapsulation of live animal cells |
US4391909A (en) * | 1979-03-28 | 1983-07-05 | Damon Corporation | Microcapsules containing viable tissue cells |
US4663286A (en) * | 1984-02-13 | 1987-05-05 | Damon Biotech, Inc. | Encapsulation of materials |
US4806355A (en) * | 1983-06-06 | 1989-02-21 | Connaught Laboratories Limited | Microencapsulation of living tissue and cells |
US4942129A (en) * | 1987-07-28 | 1990-07-17 | Queen's University At Kingston | Multiple membrane microencapsulation |
Family Cites Families (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3093831A (en) * | 1959-10-22 | 1963-06-18 | Jordan Gerhard Paul Wilhelm | Artificial gland |
US3615024A (en) * | 1968-08-26 | 1971-10-26 | Amicon Corp | High flow membrane |
US4324683A (en) * | 1975-08-20 | 1982-04-13 | Damon Corporation | Encapsulation of labile biological material |
US4251387A (en) * | 1979-04-17 | 1981-02-17 | Damon Corporation | Process for preparing semipermeable microcapsules |
US4409331A (en) * | 1979-03-28 | 1983-10-11 | Damon Corporation | Preparation of substances with encapsulated cells |
US4352883A (en) * | 1979-03-28 | 1982-10-05 | Damon Corporation | Encapsulation of biological material |
US4298002A (en) * | 1979-09-10 | 1981-11-03 | National Patent Development Corporation | Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation |
US4407957A (en) * | 1981-03-13 | 1983-10-04 | Damon Corporation | Reversible microencapsulation of a core material |
NO163060C (en) * | 1981-03-13 | 1990-03-28 | Damon Biotech Inc | PROCEDURE FOR THE PREPARATION OF SUBSTANCES MADE BY LIVING CELLS PRODUCING INTERFERONES OR ANTIBODIES. |
NO161446C (en) * | 1981-03-13 | 1989-08-16 | Damon Biotech Inc | PROCEDURE FOR CULTING CELLS RELATED TO ANCHORING. |
NO158284C (en) * | 1981-03-13 | 1988-08-17 | Damon Biotech Inc | PROCEDURE FOR SELECTIVE USE OF A PERMEABLE MEMBRANE. |
JPS59501747A (en) * | 1982-09-29 | 1984-10-18 | スピ−ルバ−グ セオドア− イ− | Encapsulated genetically engineered organisms capable of producing therapeutic substances |
US4479796A (en) * | 1982-11-15 | 1984-10-30 | Medtronic, Inc. | Self-regenerating drug administration device |
EP0127989A3 (en) * | 1983-06-01 | 1986-03-26 | Connaught Laboratories Limited | Microencapsulation of living tissue and cells |
US4689293A (en) * | 1983-06-06 | 1987-08-25 | Connaught Laboratories Limited | Microencapsulation of living tissue and cells |
AU3542684A (en) * | 1983-11-15 | 1985-05-23 | Johnson & Johnson Corporation | Glycemia regulating implant |
US4749620A (en) * | 1984-02-15 | 1988-06-07 | Massachusetts Institute Of Technology | Encapsulated active material system |
FR2559780B1 (en) * | 1984-02-21 | 1990-05-04 | Tech Cuir Centre | IMPLANTABLE BIOCOMPATIBLE COLLAGEN-BASED SYSTEMS FOR CELL STORAGE AND / OR CULTURE AND / OR CONTROLLED RELEASE OF ACTIVE INGREDIENTS |
US4686098A (en) * | 1984-05-14 | 1987-08-11 | Merck & Co., Inc. | Encapsulated mouse cells transformed with avian retrovirus-bovine growth hormone DNA, and a method of administering BGH in vivo |
CA1215922A (en) * | 1984-05-25 | 1986-12-30 | Connaught Laboratories Limited | Microencapsulation of living tissue and cells |
DE3506288A1 (en) * | 1984-09-06 | 1986-03-13 | Johannes 7900 Ulm Reinmüller | DEVICE FOR INSERTING IN Wounds and Wound Caves |
GB8500121D0 (en) * | 1985-01-03 | 1985-02-13 | Connaught Lab | Microencapsulation of living cells |
US4868121A (en) * | 1985-02-07 | 1989-09-19 | Mcdonnell Douglas Corporation | Islet isolation process |
US4663288A (en) * | 1985-05-22 | 1987-05-05 | Nabisco Brands, Inc. | Process for purification of enzymes |
US4997443A (en) * | 1985-08-26 | 1991-03-05 | Hana Biologics, Inc. | Transplantable artificial tissue and process |
US4902295A (en) * | 1985-08-26 | 1990-02-20 | Hana Biologics, Inc. | Transplantable artificial tissue |
US4976709A (en) * | 1988-12-15 | 1990-12-11 | Sand Bruce J | Method for collagen treatment |
DE3545237A1 (en) * | 1985-12-20 | 1987-06-25 | Juergen Dr Med Schrezenmeir | DEVICE FOR TAKING AND INSERTING TISSUE INTO THE HUMAN BODY AND INSTRUMENT USED THEREFOR |
ES2024418B3 (en) * | 1985-12-26 | 1992-03-01 | Taisho Pharmaceutical Co Ltd | SOFT CAPSULE WITHOUT SEAM. |
WO1987004367A1 (en) * | 1986-01-23 | 1987-07-30 | Ltl Associates | Covalent membranes |
IL79052A0 (en) * | 1986-06-06 | 1986-11-30 | Univ Ramot | Device and process for production of alginate-shell beads containing biologically active material |
WO1988000237A1 (en) * | 1986-06-27 | 1988-01-14 | Damon Biotech, Inc. | Covalent membranes |
US5026365A (en) * | 1987-04-29 | 1991-06-25 | The University Of Massachusetts | Method and apparatus for therapeutically treating immunological disorders and disease states |
US4883666A (en) * | 1987-04-29 | 1989-11-28 | Massachusetts Institute Of Technology | Controlled drug delivery system for treatment of neural disorders |
US4911717A (en) * | 1987-06-18 | 1990-03-27 | Gaskill Iii Harold V | Intravasular artificial organ |
GB2212067B (en) * | 1987-11-12 | 1991-08-07 | Michael Robin Baugh | Board game apparatus |
US5158881A (en) * | 1987-11-17 | 1992-10-27 | Brown University Research Foundation | Method and system for encapsulating cells in a tubular extrudate in separate cell compartments |
US4892538A (en) * | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
US5106627A (en) * | 1987-11-17 | 1992-04-21 | Brown University Research Foundation | Neurological therapy devices |
US5283187A (en) * | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
US5182111A (en) * | 1987-11-17 | 1993-01-26 | Boston University Research Foundation | In vivo delivery of active factors by co-cultured cell implants |
US5156844A (en) * | 1987-11-17 | 1992-10-20 | Brown University Research Foundation | Neurological therapy system |
GB2211103A (en) * | 1987-12-18 | 1989-06-28 | Flaxman Binns Frances Julia | Toy or games equipment |
US5011472A (en) * | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
US5011486A (en) * | 1988-11-18 | 1991-04-30 | Brown University Research Foundation | Composite nerve guidance channels |
US5082670A (en) * | 1988-12-15 | 1992-01-21 | The Regents Of The University Of California | Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system |
EP0478671B1 (en) * | 1989-06-21 | 1993-05-19 | Brown University Research Foundation | Neurological therapy system |
WO1991000119A1 (en) * | 1989-06-30 | 1991-01-10 | Baxter International Inc. | Implantable device |
EP0480976B1 (en) * | 1989-07-01 | 1994-04-13 | ZF FRIEDRICHSHAFEN Aktiengesellschaft | Downshift securing device |
US5002661A (en) * | 1989-08-25 | 1991-03-26 | W. R. Grace & Co.-Conn. | Artificial pancreatic perfusion device |
US5291484A (en) * | 1989-09-04 | 1994-03-01 | Fujitsu Limited | Relay and exchange system for time division multiplex data |
GB2238059A (en) * | 1989-11-17 | 1991-05-22 | Command International Inc | Electrolytic gas generating apparatus for producing a combustible mixture of hydrogen and oxygen by electrolysis of water for particular use in gas welding |
WO1991007951A1 (en) * | 1989-12-05 | 1991-06-13 | Trancel Corporation | Homologous guluronic acid alginate coating composition for in-vivo application and implantation and method of using same |
WO1991009119A1 (en) * | 1989-12-13 | 1991-06-27 | Trancel Corporation | Improved alginate microcapsules, methods of making and using same |
WO1991010470A1 (en) * | 1990-01-08 | 1991-07-25 | Brown University Research Foundation | Devices and methods for enhanced delivery of active factors |
US5084350A (en) * | 1990-02-16 | 1992-01-28 | The Royal Institution For The Advance Of Learning (Mcgill University) | Method for encapsulating biologically active material including cells |
AU651654B2 (en) * | 1992-01-14 | 1994-07-28 | Endo Pharmaceuticals Solutions Inc. | Manufacture of water-swellable hydrophilic articles and drug delivery devices |
WO1992007525A1 (en) * | 1990-10-31 | 1992-05-14 | Baxter International Inc. | Close vascularization implant material |
US5144069A (en) * | 1990-12-13 | 1992-09-01 | Minnesota Mining And Manufacturing Company | Process for the preparation of fluoroaliphatic aminocarboxylate surfactants |
US5158844A (en) * | 1991-03-07 | 1992-10-27 | The Dexter Corporation | Battery separator |
EP0585368B1 (en) * | 1991-04-25 | 1997-08-06 | Brown University Research Foundation | Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products |
SG48792A1 (en) * | 1991-06-28 | 1998-05-18 | Univ Brown Res Found | Renewable neural implant device and method |
EP0550719B1 (en) * | 1991-06-28 | 1997-03-05 | Brown University Research Foundation | Neural implant system |
AU661021B2 (en) * | 1991-06-28 | 1995-07-13 | Brown University Research Foundation | Capsule extrusion systems |
WO1993003901A1 (en) * | 1991-08-23 | 1993-03-04 | W.R. Grace & Co. - Conn. | Implantable immunoisolated therapeutic devices |
AU4114993A (en) * | 1992-04-24 | 1993-11-29 | Polymer Technology Group, Inc., The | Biocompatible, therapeutic, implantable device |
EP0640126A1 (en) * | 1992-04-24 | 1995-03-01 | Somatix Therapy Corporation | Method of culturing viable cells and method of regulating the level of a compound in a body fluid |
BE1009510A5 (en) * | 1995-07-24 | 1997-04-01 | Dijk Aart Van | PROGRAMMABLE LOGIC CONTROL UNIT. |
-
1992
- 1992-04-22 EP EP92912606A patent/EP0585368B1/en not_active Expired - Lifetime
- 1992-04-22 ES ES92912606T patent/ES2107537T3/en not_active Expired - Lifetime
- 1992-04-22 DE DE69221484T patent/DE69221484T2/en not_active Expired - Lifetime
- 1992-04-22 AU AU20041/92A patent/AU666118B2/en not_active Expired
- 1992-04-22 AT AT92912606T patent/ATE156344T1/en active
- 1992-04-22 CA CA002109085A patent/CA2109085C/en not_active Expired - Lifetime
- 1992-04-22 DK DK92912606.8T patent/DK0585368T3/en active
- 1992-04-22 WO PCT/US1992/003327 patent/WO1992019195A1/en active IP Right Grant
- 1992-04-22 SG SG1996002017A patent/SG47470A1/en unknown
- 1992-04-22 JP JP51189892A patent/JP4215273B2/en not_active Expired - Lifetime
-
1993
- 1993-10-14 FI FI934545A patent/FI934545A/en unknown
- 1993-10-25 NO NO933842A patent/NO308198B1/en not_active IP Right Cessation
-
1994
- 1994-01-10 US US08/179,151 patent/US5800828A/en not_active Expired - Lifetime
-
1995
- 1995-05-24 US US08/449,524 patent/US5798113A/en not_active Expired - Lifetime
- 1995-05-24 US US08/449,214 patent/US5834001A/en not_active Expired - Lifetime
- 1995-05-24 US US08/449,062 patent/US5871767A/en not_active Expired - Lifetime
- 1995-05-24 US US08/449,837 patent/US5874099A/en not_active Expired - Lifetime
- 1995-05-24 US US08/449,562 patent/US5869077A/en not_active Expired - Lifetime
- 1995-11-23 AU AU39020/95A patent/AU682796B2/en not_active Expired
-
1997
- 1997-11-06 GR GR970402942T patent/GR3025301T3/en unknown
-
1998
- 1998-02-04 HK HK98100825A patent/HK1001832A1/en not_active IP Right Cessation
- 1998-09-04 US US09/148,671 patent/US6083523A/en not_active Expired - Lifetime
-
2000
- 2000-05-02 US US09/563,248 patent/US6322804B1/en not_active Expired - Fee Related
-
2001
- 2001-10-25 US US10/007,344 patent/US20020150603A1/en not_active Abandoned
-
2003
- 2003-07-21 US US10/624,081 patent/US6960351B2/en not_active Expired - Fee Related
-
2007
- 2007-08-03 JP JP2007203689A patent/JP2007314569A/en not_active Withdrawn
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4391909A (en) * | 1979-03-28 | 1983-07-05 | Damon Corporation | Microcapsules containing viable tissue cells |
US4353888A (en) * | 1980-12-23 | 1982-10-12 | Sefton Michael V | Encapsulation of live animal cells |
US4806355A (en) * | 1983-06-06 | 1989-02-21 | Connaught Laboratories Limited | Microencapsulation of living tissue and cells |
US4663286A (en) * | 1984-02-13 | 1987-05-05 | Damon Biotech, Inc. | Encapsulation of materials |
US4942129A (en) * | 1987-07-28 | 1990-07-17 | Queen's University At Kingston | Multiple membrane microencapsulation |
Cited By (248)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5786216A (en) * | 1987-11-17 | 1998-07-28 | Cytotherapeutics, Inc. | Inner-supported, biocompatible cell capsules |
US6315994B2 (en) | 1992-02-24 | 2001-11-13 | Anton-Lewis Usala | Medium and matrix for long-term proliferation of cells |
US6730315B2 (en) | 1992-02-24 | 2004-05-04 | Encelle, Inc. | Medium and matrix for long-term proliferation of cells |
US5834005A (en) * | 1992-02-24 | 1998-11-10 | Encelle, Inc. | Bioartificial devices and cellular matrices therefor |
US5830492A (en) * | 1992-02-24 | 1998-11-03 | Encelle, Inc. | Bioartificial devices and cellular matrices therefor |
US5824331A (en) * | 1992-02-24 | 1998-10-20 | Encelle, Inc. | Bioartificial devices and cellular matrices therefor |
US6352707B1 (en) | 1992-02-24 | 2002-03-05 | Anton-Lewis Usala | Transplant encapsulation in a hydrogel matrix to obscure immune recognition |
US6231881B1 (en) | 1992-02-24 | 2001-05-15 | Anton-Lewis Usala | Medium and matrix for long-term proliferation of cells |
US6713079B2 (en) | 1992-02-24 | 2004-03-30 | Encelle, Inc. | Methods for increasing vascularization and promoting wound healing |
EP0674497A1 (en) * | 1992-11-16 | 1995-10-04 | Brown University Research Foundation | Microporous macrocapsules |
EP0674497A4 (en) * | 1992-11-16 | 1997-08-20 | Univ Brown Res Found | Microporous macrocapsules. |
US6730298B2 (en) * | 1993-04-30 | 2004-05-04 | Massachusetts Institute Of Technology | Tissue formation by injecting a cell-polymeric solution that gels in vivo |
US7807150B2 (en) | 1993-04-30 | 2010-10-05 | Massachusetts Institute Of Technology | Injectable composition containing crosslinkable material and cells for forming animal tissue |
US5709854A (en) * | 1993-04-30 | 1998-01-20 | Massachusetts Institute Of Technology | Tissue formation by injecting a cell-polymeric solution that gels in vivo |
US5980889A (en) * | 1993-08-10 | 1999-11-09 | Gore Hybrid Technologies, Inc. | Cell encapsulating device containing a cell displacing core for maintaining cell viability |
US6426214B1 (en) * | 1993-08-10 | 2002-07-30 | Gore Enterprise Holdings, Inc. | Cell encapsulating device containing a cell displacing core for maintaining cell viability |
WO1995005452A3 (en) * | 1993-08-12 | 1995-03-30 | Cytotherapeutics Inc | Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules |
WO1995005452A2 (en) * | 1993-08-12 | 1995-02-23 | Cytotherapeutics, Inc. | Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules |
JP2008133285A (en) * | 1993-08-12 | 2008-06-12 | Neurotech Usa Inc | Biocompatible immunity quarantined capsule containing genetically modified cells |
US5676943A (en) * | 1993-08-12 | 1997-10-14 | Cytotherapeutics, Inc. | Compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules |
US6264941B1 (en) | 1993-08-12 | 2001-07-24 | Neurotech S.A. | Compositions for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules |
US5908623A (en) * | 1993-08-12 | 1999-06-01 | Cytotherapeutics, Inc. | Compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules |
EP1179350A2 (en) * | 1993-08-12 | 2002-02-13 | Cytotherapeutics, Inc. | Encapsulated cell system for implantation into the human CNS |
EP1179350A3 (en) * | 1993-08-12 | 2003-01-02 | Cytotherapeutics, Inc. | Encapsulated cell system for implantation into the human CNS |
US5653975A (en) * | 1993-08-12 | 1997-08-05 | Cytotherapeutics, Inc. | Compositions and methods for the delivery of biologically active molecules using cells contained in biocompatible capsules |
US5639275A (en) * | 1993-08-12 | 1997-06-17 | Cytotherapeutics, Inc. | Delivery of biologically active molecules using cells contained in biocompatible immunoisolatory capsules |
US5656481A (en) * | 1993-08-12 | 1997-08-12 | Cyto Therapeutics, Inc. | Compositions and methods for the delivery of biologically active molecules using cells contained in biocompatible capsules |
EP0733101A4 (en) * | 1993-12-10 | 1999-06-23 | Cytotherapeutics Inc | Glucose responsive insulin secreting beta-cell lines and method for producing same |
EP0733101A1 (en) * | 1993-12-10 | 1996-09-25 | Cytotherapeutics | Glucose responsive insulin secreting beta-cell lines and method for producing same |
US5550050A (en) * | 1994-04-15 | 1996-08-27 | Cytotherapeutics, Inc. | Method for implanting encapsulated cells in a host |
EP1632238A1 (en) | 1994-04-15 | 2006-03-08 | Neurotech S.A. | Encapsulated cells adapted for implantation into the aqueous and vitreous humor of the eye |
EP0679402A2 (en) * | 1994-04-25 | 1995-11-02 | Research Development Corporation Of Japan | Biologically active substance-secreting hybrid gel |
EP0679402A3 (en) * | 1994-04-25 | 1997-04-23 | Japan Res Dev Corp | Biologically active substance-secreting hybrid gel. |
AU779272B2 (en) * | 1994-04-25 | 2005-01-13 | Genentech Inc. | Biologically active substance-secreting hybrid gel |
US6156572A (en) * | 1994-07-20 | 2000-12-05 | Neurotech S.A. | Bioartificial extracellular matrix containing hydrogel matrix derivatized with cell adhesive peptide fragment |
US5795790A (en) * | 1994-07-20 | 1998-08-18 | Cytotherapeutics, Inc. | Method for controlling proliferation and differentiation of cells encapsulated within bioartificial organs |
US5776747A (en) * | 1994-07-20 | 1998-07-07 | Cytotherapeutics, Inc. | Method for controlling the distribution of cells within a bioartificial organ using polycthylene oxide-poly (dimethylsiloxane) copolymer |
US5853717A (en) * | 1994-07-20 | 1998-12-29 | Cytotherapeutics, Inc. | Methods and compositions of growth control for cells encapsulated within bioartificial organs |
US5858747A (en) * | 1994-07-20 | 1999-01-12 | Cytotherapeutics, Inc. | Control of cell growth in a bioartificial organ with extracellular matrix coated microcarriers |
US5840576A (en) * | 1994-07-20 | 1998-11-24 | Cytotherapeutics, Inc. | Methods and compositions of growth control for cells encapsulated within bioartificial organs |
US5834029A (en) * | 1994-07-20 | 1998-11-10 | Cytotherapeutics, Inc. | Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment |
US5935849A (en) * | 1994-07-20 | 1999-08-10 | Cytotherapeutics, Inc. | Methods and compositions of growth control for cells encapsulated within bioartificial organs |
US5833979A (en) * | 1994-07-20 | 1998-11-10 | Cytotherapeutics, Inc. | Methods and compositions of growth control for cells encapsulated within bioartificial organs |
US6392118B1 (en) | 1994-07-20 | 2002-05-21 | Neurotech S.A. | Mx-1 conditionally immortalized cells |
EP1983053A2 (en) | 1994-07-20 | 2008-10-22 | Neurotech USA, Inc. | Cell distribution control for cells within bioartifical organs |
US5853385A (en) * | 1994-08-26 | 1998-12-29 | Cytotherapeutics, Inc. | Encapsulated PC12 cell transplants for treatment of Parkinson's disease |
WO1996028029A1 (en) * | 1995-03-10 | 1996-09-19 | Biohybrid Technologies, Inc. | Immunoisolation |
US6126936A (en) * | 1995-03-10 | 2000-10-03 | Biohybrid Technologies Llc | Microcapsules and composite microreactors for immunoisolation of cells |
AU721726B2 (en) * | 1995-03-10 | 2000-07-13 | Biohybrid Technologies, Inc. | Immunoisolation |
US6495364B2 (en) * | 1995-05-23 | 2002-12-17 | Neurotech, S.A. | Mx-1 conditionally immortalized cells |
US5681740A (en) * | 1995-06-05 | 1997-10-28 | Cytotherapeutics, Inc. | Apparatus and method for storage and transporation of bioartificial organs |
WO1996040871A1 (en) * | 1995-06-07 | 1996-12-19 | Cytotherapeutics, Inc. | Bioartificial organs comprising open pored foam-like membranes |
WO1996040887A1 (en) * | 1995-06-07 | 1996-12-19 | Children's Medical Center Corporation | Immunoprotective barrier for transplantation of cells |
US5741685A (en) * | 1995-06-07 | 1998-04-21 | Children's Medical Center Corporation | Parenchymal cells packaged in immunoprotective tissue for implantation |
US5837234A (en) * | 1995-06-07 | 1998-11-17 | Cytotherapeutics, Inc. | Bioartificial organ containing cells encapsulated in a permselective polyether suflfone membrane |
US5902745A (en) * | 1995-09-22 | 1999-05-11 | Gore Hybrid Technologies, Inc. | Cell encapsulation device |
WO1997012635A1 (en) * | 1995-10-02 | 1997-04-10 | Cytotherapeutics, Inc. | Method for treating amyotrophic lateral sclerosis |
US7361334B2 (en) | 1995-10-26 | 2008-04-22 | Latta Paul P | Method of treatment of diabetes through induction of immunological tolerance |
US7361333B2 (en) | 1995-10-26 | 2008-04-22 | Latta Paul P | Prevention of diabetes through induction of immunological tolerance |
WO1997020569A2 (en) * | 1995-12-07 | 1997-06-12 | Encelle, Inc. | Bioartificial devices and cellular matrices therefor |
WO1997020569A3 (en) * | 1995-12-07 | 1997-09-18 | Encelle Inc | Bioartificial devices and cellular matrices therefor |
US6436427B1 (en) | 1996-03-22 | 2002-08-20 | Neurotech S.A. | Device and method for treating ophthalmic diseases |
US6649184B2 (en) | 1996-03-22 | 2003-11-18 | Neurotech S.A. | Device and method for treating ophthalmic diseases |
WO1997037003A1 (en) * | 1996-03-29 | 1997-10-09 | Desmos, Inc. | Laminin 5 for growth of pancreatic islet cells |
WO1997038707A1 (en) * | 1996-04-17 | 1997-10-23 | Cytotherapeutics, Inc. | Method and device for delivery of apoptosis-inducing molecules |
WO1997044065A2 (en) * | 1996-05-20 | 1997-11-27 | Cytotherapeutics, Inc. | Device and method for encapsulated gene therapy |
AU708173B2 (en) * | 1996-05-20 | 1999-07-29 | Cytotherapeutics, Inc. | Device and method for encapsulated gene therapy |
US6027721A (en) * | 1996-05-20 | 2000-02-22 | Cytotherapeutics, Inc. | Device and method for encapsulated gene therapy |
WO1997044065A3 (en) * | 1996-05-20 | 1997-12-24 | Cytotherapeutics Inc | Device and method for encapsulated gene therapy |
US6054142A (en) * | 1996-08-01 | 2000-04-25 | Cyto Therapeutics, Inc. | Biocompatible devices with foam scaffolds |
US6231879B1 (en) | 1996-08-01 | 2001-05-15 | Neurotech S.A. | Biocompatible devices with foam scaffolds |
US6156728A (en) * | 1996-11-01 | 2000-12-05 | Genentech, Inc. | Treatment of inner ear hair cells |
US6927204B2 (en) | 1996-11-01 | 2005-08-09 | Genentech, Inc. | Treatment of inner ear hair cells |
US6593290B1 (en) | 1996-11-01 | 2003-07-15 | Genentech, Inc. | Treatment of inner ear hair cells |
US6653279B1 (en) | 1996-11-01 | 2003-11-25 | Genentech, Inc. | Treatment of inner ear hair cells |
WO1998019695A1 (en) * | 1996-11-05 | 1998-05-14 | Modex Therapeutiques | Device and method for delivery of erythropoietin |
US5952226A (en) * | 1996-11-05 | 1999-09-14 | Modex Therapeutiques | Hypoxia responsive EPO producing cells |
US6252051B1 (en) | 1997-07-09 | 2001-06-26 | Genentech, Inc. | ErbB4 receptor-specific neuregulin related ligand antibodies and uses therefor |
US6121415A (en) * | 1997-07-09 | 2000-09-19 | Genentech, Inc. | ErbB4 receptor-specific neuregolin related ligands and uses therefor |
US7662585B2 (en) | 1997-07-09 | 2010-02-16 | Genentech, Inc. | ErbB4 receptor-specific neuregulin related ligands and uses therefor |
US7846453B2 (en) | 1997-07-09 | 2010-12-07 | Genentech, Inc. | Methods of stimulating ErbB4 receptor phosphorylation |
US6994856B1 (en) | 1997-07-24 | 2006-02-07 | Genentech, Inc. | ErbB4 receptor-specific neuregulin related ligands and uses therefor |
US6287558B1 (en) | 1997-08-01 | 2001-09-11 | Biohybrio Technologies Llc | Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule |
WO1999005989A2 (en) * | 1997-08-01 | 1999-02-11 | Biohybrid Technologies, Inc. | Devices for providing therapeutic substances |
WO1999005989A3 (en) * | 1997-08-01 | 1999-04-08 | Biohybrid Tech Inc | Devices for providing therapeutic substances |
US5922339A (en) * | 1998-01-27 | 1999-07-13 | Usala; Anton-Lewis | Compositions and methods for biocompatible implants |
US6303136B1 (en) | 1998-04-13 | 2001-10-16 | Neurotech S.A. | Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane |
US6627422B1 (en) | 1998-04-13 | 2003-09-30 | Neurotech S.A. | Device containing cell-supporting yarn matrix encapsulated in a semi-permeable membrane |
EP1073420A4 (en) * | 1998-05-14 | 2004-09-08 | Abraham Shahar | Specially devised neuronal implants for reconstruction of damaged central nervous system |
EP1073420A2 (en) * | 1998-05-14 | 2001-02-07 | Abraham Shahar | Specially devised neuronal implants for reconstruction of damaged central nervous system |
WO1999060105A1 (en) * | 1998-05-15 | 1999-11-25 | Modex Therapeutiques, S.A. | Flat sheet cell encapsulation device |
EP2290079A2 (en) | 1998-07-06 | 2011-03-02 | NsGene A/S | Neurotrophic factors |
US6261587B1 (en) | 1998-07-10 | 2001-07-17 | Anton-Lewis Usala | Methods for increasing vascularization and promoting wound healing |
US6926888B1 (en) | 1998-08-26 | 2005-08-09 | Fmc Biopolymer As | Alginate capsules for use in the treatment of brain tumor |
WO2000012066A1 (en) * | 1998-08-26 | 2000-03-09 | Norsk Hydro Asa | Alginate capsules for use in the treatment of brain tumour |
US7125837B1 (en) | 1999-02-26 | 2006-10-24 | University Of Utah Research Foundation | Elastin-based compositions |
US7115257B1 (en) | 1999-04-06 | 2006-10-03 | Neurotech S.A. | ARPE-19 as a platform cell line for encapsulated cell-based delivery |
US6361771B1 (en) | 1999-04-06 | 2002-03-26 | Neurotech S.A. | ARPE-19 as a platform cell line for encapsulated cell-based delivery |
US7651853B2 (en) | 1999-10-25 | 2010-01-26 | Nsgene A/S | Cultures of GFAP+ nestin+ cells that differentiate to neurons |
US8501467B2 (en) | 1999-10-25 | 2013-08-06 | Stemcells California, Inc. | Cultures of GFAP+ nestin+ cells that differentiate to neurons |
US7303912B2 (en) | 1999-10-25 | 2007-12-04 | Nsgene A/S | Cultures of GFAP nestin cells that differentiate to neurons |
US6878543B1 (en) | 1999-10-25 | 2005-04-12 | Nsgene Sa | Cultures of GFAP+ nestin+ cells that differentiate to neurons |
US8012500B2 (en) | 2000-01-01 | 2011-09-06 | Beta-O2 Technologies Ltd. | Implantable device |
US8444630B2 (en) | 2000-01-12 | 2013-05-21 | Beta-O2 Technologies Ltd. | Oxygen supply for cell transplant and vascularization |
US6992062B2 (en) | 2000-05-31 | 2006-01-31 | Encelle, Inc. | Method of stimulation hair growth |
US7700660B2 (en) | 2000-05-31 | 2010-04-20 | Encelle, Inc. | Method of treating chronic ulcers |
US8119114B2 (en) | 2001-02-01 | 2012-02-21 | Biogen Idec Ma Inc. | Polymer conjugates of mutated neublastin |
US7655463B2 (en) | 2001-03-12 | 2010-02-02 | Biogen Idec Ma Inc. | Methods of activating RET receptor tyrosine kinase using neurotrophic factors |
US8217146B2 (en) | 2001-03-12 | 2012-07-10 | Biogen Idec Ma Inc. | Neurotrophic factors and methods of use thereof |
US8609122B2 (en) | 2002-02-21 | 2013-12-17 | Pioneer Surgical Technology, Inc. | Immobilized bioactive hydrogel matrices as surface coatings |
US7303814B2 (en) | 2002-02-21 | 2007-12-04 | Encelle, Inc. | Immobilized bioactive hydrogel matrices as surface coatings |
US8053423B2 (en) | 2002-02-21 | 2011-11-08 | Encelle, Inc. | Method of preparing cross-linked bioactive hydrogel matrices |
US9623146B2 (en) | 2002-02-21 | 2017-04-18 | RTI Surgical Technology, Inc. | Bone implant materials comprising cross-linked bioactive hydrogel matrices |
US9610382B2 (en) | 2002-02-21 | 2017-04-04 | Rti Surgical, Inc. | Immobilized bioactive hydrogel matrices as surface coatings |
US10383981B2 (en) | 2002-02-21 | 2019-08-20 | Pioneer Surgical Technology, Inc. | Structural lattice and method of making same |
US8664202B2 (en) | 2002-02-21 | 2014-03-04 | Pioneer Surgical Technology, Inc. | Cross-linked bioactive hydrogel matrices |
US10265436B2 (en) | 2002-02-21 | 2019-04-23 | Pioneer Surgical Technology, Inc. | Immobilized bioactive hydrogel matrices as surface coatings |
US7799767B2 (en) | 2002-02-21 | 2010-09-21 | Pioneer Surgical Orthobiologics, Inc. | Cross-linked bioactive hydrogel matrices |
US8957050B2 (en) | 2002-02-21 | 2015-02-17 | Pioneer Surgical Technology, Inc. | Bone implant materials comprising cross-linked bioactive hydrogel matrices |
US8173372B2 (en) | 2002-05-16 | 2012-05-08 | Absorber Ab | Methods of donor specific crossmatching |
US8034635B2 (en) | 2002-05-16 | 2011-10-11 | Absorber Ab | Methods of donor specific crossmatching |
EP2119728A1 (en) | 2002-11-29 | 2009-11-18 | The Corporation Of The Trustees Of The Order Of The Sisters Of Mercy In Queensland | Therapeutic and diagnostic agents |
US8163875B2 (en) | 2003-04-18 | 2012-04-24 | Biogen Idec Ma Inc. | Polymer conjugated glycosylated neublastin |
US8642732B2 (en) | 2003-04-18 | 2014-02-04 | Biogen Idec Ma Inc. | Polymer-conjugated glycosylated neublastin |
EP2058329A1 (en) | 2003-06-10 | 2009-05-13 | NsGene A/S | Improved secretion of neublastin |
WO2004108760A2 (en) | 2003-06-10 | 2004-12-16 | Nsgene A/S | Improved secretion of neublastin |
WO2005020677A1 (en) | 2003-08-29 | 2005-03-10 | The Walter And Eliza Hall Institute Of Medical Research | Method of selecting animal models from animals which have been subject to mutagenesis, and the use of myb transcription factors for screening |
EP2210617A1 (en) | 2003-10-20 | 2010-07-28 | NsGene A/S | Mammalian cells secreting Neurturin and their therapeutic use |
WO2005060992A1 (en) | 2003-12-24 | 2005-07-07 | The Walter And Eliza Hall Institute Of Medical Research | Therapeutic agents and uses therefor |
EP2289911A2 (en) | 2004-03-30 | 2011-03-02 | NsGene A/S | Therapeutic use of a growth factor, NsG33 |
EP2075254A1 (en) | 2004-03-30 | 2009-07-01 | NsGene A/S | Therapeutic use of a growth factor, NsG33 |
WO2005108981A1 (en) | 2004-05-12 | 2005-11-17 | The Walter And Eliza Hall Institute Of Medical Research | A method of cell isolation |
US8969042B2 (en) | 2004-08-19 | 2015-03-03 | Biogen Idec Ma Inc. | Refolding transforming growth factor beta family proteins |
US8722862B2 (en) | 2004-08-19 | 2014-05-13 | Biogen Idec Ma Inc. | Refolding transforming growth factor beta family proteins |
US8263553B2 (en) | 2004-08-19 | 2012-09-11 | Biogen Idec Ma Inc. | Neublastin variants |
US7772201B2 (en) | 2004-11-17 | 2010-08-10 | “University of Maryland, Baltimore” | Highly branched HK peptides as effective carriers of siRNA |
US8088567B2 (en) | 2005-04-01 | 2012-01-03 | Nsgene A/S | Human immortalised neural precursor cell line |
US9364427B2 (en) | 2005-05-17 | 2016-06-14 | Nsgene A/S | Implantable therapy system for treating a living being with an active factor |
EP2407484A2 (en) | 2005-06-24 | 2012-01-18 | The Walter And Eliza Hall Institute Of Medical Research | Therapeutic pro-apoptotic BH3-like molecules and methods for generating and/or selecting the same |
US8357666B2 (en) | 2005-08-01 | 2013-01-22 | Nupotential, Inc. | Reprogramming a cell by inducing a pluripotent gene through RNA interference |
US9265814B2 (en) | 2005-12-30 | 2016-02-23 | Neurotech Usa, Inc. | Micronized device for the delivery of biologically active molecules and methods of use thereof |
US7820195B2 (en) | 2005-12-30 | 2010-10-26 | Neurotech Usa, Inc. | Micronized device for the delivery of biologically active molecules and methods of use thereof |
EP2609930A2 (en) | 2006-02-27 | 2013-07-03 | Biogen Idec MA Inc. | Treatments for neurological disorders |
US10328125B2 (en) | 2006-02-27 | 2019-06-25 | Gloriana Therapeutics, Inc. | Treatments for neurological disorders |
WO2008011006A2 (en) | 2006-07-18 | 2008-01-24 | University Of Utah Research Foundation | Methods for treating pain and screening analgesic compounds |
US9155749B2 (en) | 2006-09-14 | 2015-10-13 | Medgenics Medical Israel Ltd. | Long lasting drug formulations |
US8597906B2 (en) | 2007-04-03 | 2013-12-03 | Oxyrane Uk Limited | Glycosylation of molecules |
US9206408B2 (en) | 2007-04-03 | 2015-12-08 | Oxyrane Uk Limited | Microorganisms genetically engineered to have modified N-glycosylation activity |
EP2508614A2 (en) | 2007-04-03 | 2012-10-10 | Oxyrane UK Limited | Glycosylation of molecules |
US10023854B2 (en) | 2007-04-03 | 2018-07-17 | Oxyrane Uk Limited | Microorganisms genetically engineered to have modified N-glycosylation activity |
EP2508612A2 (en) | 2007-04-03 | 2012-10-10 | Oxyrane UK Limited | Glycosylation of molecules |
US9222083B2 (en) | 2007-04-03 | 2015-12-29 | Oxyrane Uk Limited | Microorganisms genetically engineered to have modified N-glycosylation activity |
US9138461B2 (en) | 2007-05-01 | 2015-09-22 | Biogen Ma Inc. | Compositions and methods for increasing vascularization |
US8329655B2 (en) | 2007-05-01 | 2012-12-11 | Biogen Idec Ma Inc. | Methods for increasing vascularization |
US8821431B2 (en) | 2007-09-07 | 2014-09-02 | Beta O2 Technologies Ltd. | Air gap for supporting cells |
US9463083B2 (en) | 2007-09-07 | 2016-10-11 | Beta-O2 Technologies Ltd. | Air gap for supporting cells |
WO2009125332A1 (en) * | 2008-04-07 | 2009-10-15 | Peter Bromley | New and safe procedure for immunization against infectious diseases agents |
WO2009126251A2 (en) | 2008-04-07 | 2009-10-15 | Nupotential, Inc. | Reprogramming a cell by inducing a pluripotent gene through use of an hdac modulator |
US9675669B2 (en) | 2008-07-24 | 2017-06-13 | Hoba Therapeutics Aps | Therapeutic use of a growth factor, METRNL |
US9068015B2 (en) | 2008-07-24 | 2015-06-30 | Nsgene A/S | Therapeutic use of a growth factor, METRNL |
US10034918B2 (en) | 2008-07-24 | 2018-07-31 | Hoba Therapeutics Aps | Therapeutic use of a growth factor, METRNL |
US8334264B2 (en) | 2008-07-24 | 2012-12-18 | NsGenee A/S | Therapeutic use of a growth factor, METRNL |
US9540630B2 (en) | 2008-09-17 | 2017-01-10 | Beta O2 Technologies Ltd. | Optimization of alginate encapsulation of islets for transplantation |
US8043271B2 (en) | 2008-11-26 | 2011-10-25 | Beta 02 Technologies Ltd. | Apparatus for transportation of oxygen to implanted cells |
WO2010075500A1 (en) | 2008-12-23 | 2010-07-01 | Stemcells California, Inc | Target populations of oligodendrocyte precursor cells and methods of making and using same |
US10400214B2 (en) | 2008-12-23 | 2019-09-03 | Boco Silicon Valley, Inc. | Target populations of oligodendrocyte precursor cells and methods of making and using same |
US10888526B2 (en) | 2009-01-23 | 2021-01-12 | Gloriana Therapeutics Sarl | Cell lines and their use in encapsulated cell biodelivery |
WO2010083841A2 (en) | 2009-01-23 | 2010-07-29 | Nsgene A/S | Improved cell lines and their use in encapsulated cell biodelivery |
WO2010083842A2 (en) | 2009-01-23 | 2010-07-29 | Nsgene A/S | Expression of neuropeptides in mammalian cells |
US9452185B2 (en) | 2009-03-23 | 2016-09-27 | The Texas A&M University System | Mesenchymal stem cells and supports for tissue regeneration, repair and reconstruction |
US9511093B2 (en) | 2009-03-23 | 2016-12-06 | The Texas A & M University System | Compositions of mesenchymal stem cells to regenerate bone |
WO2010142007A1 (en) | 2009-06-09 | 2010-12-16 | Universidade Bandeirante De São Paulo - Academia Paulista Anchieta S/C Ltda | Pharmaceutical composition and use of the pharmaceutical composition for the treatment, prophylaxis or prevention of neoplastic diseases in humans and animals |
WO2011039634A2 (en) | 2009-09-29 | 2011-04-07 | Universiteit Gent | Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose |
US10392609B2 (en) | 2009-09-29 | 2019-08-27 | Oxyrane Uk Limited | Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose |
US9598682B2 (en) | 2009-09-29 | 2017-03-21 | Vib Vzw | Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose |
WO2011061629A2 (en) | 2009-11-19 | 2011-05-26 | Oxyrane Uk Limited | Yeast strains producing mammalian-like complex n-glycans |
US10287557B2 (en) | 2009-11-19 | 2019-05-14 | Oxyrane Uk Limited | Yeast strains producing mammalian-like complex N-glycans |
US11225646B2 (en) | 2009-11-19 | 2022-01-18 | Oxyrane Uk Limited | Yeast strains producing mammalian-like complex n-glycans |
US9446168B2 (en) | 2010-06-07 | 2016-09-20 | Beta-O2 Technologies Ltd. | Multiple-layer immune barrier for donor cells |
WO2012027494A1 (en) | 2010-08-24 | 2012-03-01 | Regents Of The University Of Minnesota | Bispecific targeting reagents |
US9689015B2 (en) | 2010-09-29 | 2017-06-27 | Oxyrane Uk Limited | De-mannosylation of phosphorylated N-glycans |
US9347050B2 (en) | 2010-09-29 | 2016-05-24 | Oxyrane Uk Limited | Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated N-glycans and methods of facilitating mammalian cellular uptake of glycoproteins |
WO2012042387A2 (en) | 2010-09-29 | 2012-04-05 | Oxyrane Uk Limited | De-mannosylation of phosphorylated n-glycans |
US10344310B2 (en) | 2010-09-29 | 2019-07-09 | Oxyrane Uk Limited | De-mannosylation of phosphorylated N-glycans |
WO2012042386A2 (en) | 2010-09-29 | 2012-04-05 | Oxyrane Uk Limited | Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated n-glycans and methods of facilitating mammalian cellular uptake of glycoproteins |
US10011857B2 (en) | 2010-09-29 | 2018-07-03 | Oxyrane Uk Limited | Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated N-glycans and methods of facilitating mammalian cellular uptake of glycoproteins |
WO2012041328A1 (en) | 2010-10-01 | 2012-04-05 | Nsgene A/S | Use of meteorin for the treatment of allodynia, hyperalgesia, spontaneous pain and phantom pain |
US9724367B2 (en) | 2010-11-10 | 2017-08-08 | Regenmed (Cayman) Ltd. | Injectable formulations for organ augmentation |
US9149427B2 (en) | 2010-12-02 | 2015-10-06 | Neurotech Usa, Inc. | Cell lines that secrete anti-angiogenic antibody-scaffolds and soluble receptors and uses thereof |
WO2012075184A2 (en) | 2010-12-02 | 2012-06-07 | Neurotech Usa, Inc. | Cell lines that secrete anti-angiogenic antibody-scaffolds and soluble receptors and uses thereof |
US10004804B2 (en) | 2010-12-02 | 2018-06-26 | Neurotech Usa, Inc. | Cell lines that secrete anti-angiogenic antibody-scaffolds and soluble receptors and uses thereof |
US10364440B2 (en) | 2011-01-04 | 2019-07-30 | Brown University | Nanotubes as carriers of nucleic acids into cells |
US10344300B2 (en) | 2011-01-04 | 2019-07-09 | Brown University | Nanotubes as carriers of nucleic acids into cells |
US9878058B2 (en) | 2011-06-06 | 2018-01-30 | Kv1.3 Therapeutics, Inc. | SHK-based pharmaceutical compositions and methods of manufacturing and using the same |
US9381261B2 (en) | 2011-06-06 | 2016-07-05 | Kineta One, Llc | SHK-based pharmaceutical compositions and methods of manufacturing and using the same |
US10443072B2 (en) | 2011-06-07 | 2019-10-15 | Wisconsin Alumni Research Foundation | Hepatocyte based insulin gene therapy for diabetes |
US9732356B2 (en) | 2011-06-07 | 2017-08-15 | Wisconsin Alumni Research Foundation | Hepatocyte based insulin gene therapy for diabetes |
WO2013011438A1 (en) * | 2011-07-15 | 2013-01-24 | Piramal Enterprises Limited | Alginate tube drug delivery system and method therefor |
US9474786B2 (en) | 2011-09-05 | 2016-10-25 | Nsgene A/S | Treatment of allodynia |
US9861682B2 (en) | 2011-09-05 | 2018-01-09 | Hoba Therapeutics Aps | Treatment of hyperalgesia, spontaneous pain, and phantom pain |
WO2013034157A1 (en) | 2011-09-05 | 2013-03-14 | Nsgene A/S | Treatment of allodynia, hyperalgsia, spontaneous pain, and phantom pain |
US9561247B2 (en) | 2011-11-02 | 2017-02-07 | Tif Management, Llc | Methods and compositions for wound treatment |
EP3628326A1 (en) | 2012-03-15 | 2020-04-01 | Oxyrane UK Limited | Methods and materials for treatment of pompe's disease |
US10648044B2 (en) | 2012-03-15 | 2020-05-12 | Oxyrane Uk Limited | Methods and materials for treatment of Pompe's disease |
US9249399B2 (en) | 2012-03-15 | 2016-02-02 | Oxyrane Uk Limited | Methods and materials for treatment of pompe's disease |
WO2013136189A2 (en) | 2012-03-15 | 2013-09-19 | Oxyrane Uk Limited | Methods and materials for treatment of pompe's disease |
WO2013181424A1 (en) | 2012-05-30 | 2013-12-05 | Neurotech Usa, Inc. | Cryopreserved implantable cell culture devices and uses thereof |
US10071123B2 (en) | 2012-08-01 | 2018-09-11 | United Therapeutics Corporation | Treatment of pulmonary arterial hypertension with mesenchymal stem cells |
US10016463B2 (en) | 2012-08-01 | 2018-07-10 | United Therapeutics Corporation | Treatment of pulmonary arterial hypertension with prostacyclin-treated endothelial progenitor cells |
EP3492084A1 (en) | 2012-08-01 | 2019-06-05 | United Therapeutics Corporation | Treatment of pulmonary arterial hypertension with prostacyclin-treated endothelial progenitor cells |
US10842823B2 (en) | 2012-08-01 | 2020-11-24 | United Therapeutics Corporation | Treatment of pulmonary arterial hypertension with prostacyclin-treated endothelial progenitor cells |
US11839631B2 (en) | 2012-08-01 | 2023-12-12 | United Therapeutics Corporation | Treatment of pulmonary arterial hypertension with prostacyclin-treated endothelial progenitor cells |
US11666602B2 (en) | 2012-08-01 | 2023-06-06 | United Therapeutics Corporation | Treatment of pulmonary arterial hypertension with mesenchymal stem cells |
EP3415150A1 (en) | 2013-01-09 | 2018-12-19 | United Therapeutics Corporation | Treatment of vasculopathy with prostacyclin and mesenchymal stem cells |
US11839596B2 (en) | 2013-01-09 | 2023-12-12 | United Therapeutics Corporation | Treatment of vasculopathy with prostacyclin and mesenchymal stem cells |
US10080730B2 (en) | 2013-01-09 | 2018-09-25 | United Therapeutics Corporation | Treatment of vasculopathy with prostacyclin and mesenchymal stem cells |
US11141393B2 (en) | 2013-01-09 | 2021-10-12 | United Therapeutics Corporation | Treatment of vasculopathy with prostacyclin and mesenchymal stem cells |
EP3878452A1 (en) | 2013-01-09 | 2021-09-15 | United Therapeutics Corporation | Treatment of vasculopathy with prostacyclin and mesenchymal stem cells |
WO2014136065A2 (en) | 2013-03-05 | 2014-09-12 | Oxyrane Uk Limited | Production of catalytically active type i sulfatase |
WO2014138691A1 (en) | 2013-03-07 | 2014-09-12 | Viacyte, Inc. | 3-dimensional large capacity cell encapsulation device assembly |
US11077289B2 (en) | 2013-03-07 | 2021-08-03 | Viacyte, Inc. | 3-dimensional large capacity cell encapsulation device assembly |
EP3398559A1 (en) | 2013-03-07 | 2018-11-07 | ViaCyte, Inc. | 3-dimensional large capacity cell encapsulation device assembly |
USD755986S1 (en) | 2013-03-07 | 2016-05-10 | Viacyte, Inc. | Cell encapsulation device |
US9526880B2 (en) | 2013-03-07 | 2016-12-27 | Viacyte, Inc. | 3-dimensional large capacity cell encapsulation device assembly |
US10835486B2 (en) | 2013-03-14 | 2020-11-17 | Massachusetts Institute Of Technology | Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates |
US10786446B2 (en) | 2013-03-14 | 2020-09-29 | Massachusetts Institute Of Technology | Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates |
US11446239B2 (en) | 2013-03-14 | 2022-09-20 | Massachusetts Institute Of Technology | Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates |
WO2014194284A1 (en) | 2013-05-31 | 2014-12-04 | Mcintosh J Michael | Conotoxin peptides, pharmaceutical compositions and uses thereof |
WO2015042580A1 (en) | 2013-09-23 | 2015-03-26 | Biogen Idec Ma Inc. | Compositions and methods for treatment of neuropathic pain |
US9775842B2 (en) | 2014-03-14 | 2017-10-03 | Rhode Island Hospital | Nanocarriers and their processing for diagnostics and therapeutics |
US10555948B2 (en) | 2014-03-14 | 2020-02-11 | Rhode Island Hospital | Nanocarriers and their processing for diagnostics and therapeutics |
US10575765B2 (en) | 2014-10-13 | 2020-03-03 | Glusense Ltd. | Analyte-sensing device |
US10195140B2 (en) | 2015-05-27 | 2019-02-05 | Neurotech Usa, Inc. | Use of encapsulated cell therapy for treatment of ophthalmic disorders |
EP3662923A1 (en) | 2015-05-27 | 2020-06-10 | Neurotech USA, Inc. | Use of encapsulated cell therapy for treatment of ophthalmic disorders |
US11207266B2 (en) | 2015-05-27 | 2021-12-28 | Neurotech, USA, Inc. | Use of encapsulated cell therapy for treatment of ophthalmic disorders |
US10456356B2 (en) | 2015-05-27 | 2019-10-29 | Neurotech Usa, Inc. | Use of encapsulated cell therapy for treatment of ophthalmic disorders |
WO2017070738A1 (en) | 2015-10-27 | 2017-05-04 | The University Of Queensland | A method of treatment and agents useful for same |
US10871487B2 (en) | 2016-04-20 | 2020-12-22 | Glusense Ltd. | FRET-based glucose-detection molecules |
WO2018015330A1 (en) | 2016-07-18 | 2018-01-25 | Eth Zurich | B-cell-mimetic cells |
EP3272877A1 (en) | 2016-07-18 | 2018-01-24 | ETH Zurich | B-cell-mimetic cells |
US11571444B2 (en) | 2016-10-24 | 2023-02-07 | United Therapeutics Corporation | Enhancement of MSC immunomodulatory properties by treprostinil |
US11623023B2 (en) | 2016-11-10 | 2023-04-11 | Viacyte, Inc. | PDX1 pancreatic endoderm cells in cell delivery devices and methods thereof |
US11701379B2 (en) | 2018-03-26 | 2023-07-18 | Rhode Island Hospital | In vitro and in vivo intracellular delivery of siRNA via self-assembled nanopieces |
US20220000789A1 (en) * | 2018-09-27 | 2022-01-06 | Sigilon Therapeutics, Inc. | Implantable devices for cell therapy and related methods |
WO2020262642A1 (en) | 2019-06-28 | 2020-12-30 | 持田製薬株式会社 | Transplantation device using chemically crosslinked alginic acid |
EP3777827A1 (en) * | 2019-08-14 | 2021-02-17 | MaxiVax SA | Implantable capsule |
WO2022137345A1 (en) | 2020-12-22 | 2022-06-30 | 持田製薬株式会社 | Transplantation device using chemically crosslinked alginic acid |
KR20230123959A (en) | 2020-12-22 | 2023-08-24 | 모찌다 세이야쿠 가부시끼가이샤 | Implantable device using chemically cross-linked alginic acid |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2109085C (en) | Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products | |
US5800829A (en) | Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core | |
US9265814B2 (en) | Micronized device for the delivery of biologically active molecules and methods of use thereof | |
EP0742818B1 (en) | Macroencapsulated secretory cells | |
Colton | Implantable biohybrid artificial organs | |
De Haan et al. | Factors influencing insulin secretion from encapsulated islets | |
CA2149420C (en) | Microporous macrocapsules | |
Lanza et al. | Experimental xenotransplantation of encapsulated cells |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AU CA FI JP KR NO US |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LU MC NL SE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 934545 Country of ref document: FI |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2109085 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1992912606 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 08179151 Country of ref document: US |
|
WWP | Wipo information: published in national office |
Ref document number: 1992912606 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: 1994 140015 Country of ref document: US Date of ref document: 19940617 Kind code of ref document: A |
|
WWG | Wipo information: grant in national office |
Ref document number: 1992912606 Country of ref document: EP |