WO1992012745A1 - Subcutaneous injector - Google Patents
Subcutaneous injector Download PDFInfo
- Publication number
- WO1992012745A1 WO1992012745A1 PCT/GB1992/000081 GB9200081W WO9212745A1 WO 1992012745 A1 WO1992012745 A1 WO 1992012745A1 GB 9200081 W GB9200081 W GB 9200081W WO 9212745 A1 WO9212745 A1 WO 9212745A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- piston
- needle
- barrel
- injector according
- seal
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2066—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/206—With automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M2005/3131—Syringe barrels specially adapted for improving sealing or sliding
Definitions
- a disposable subcutaneous injector comprises a first piston acted on by a spring held back until use by a safety catch, a second piston carrying the needle sealed to it, the medicament being contained substantially wholly in the space in the barrel defined between the two pistons, and the needle projecting in air, not in medicament, from the second piston towards the end of the barrel where there are both a penetrable diaphragm seal and also a tubular seal or guide which is already entered by the tip of the needle in its rest position.
- a disposable injector which is simple to use, low in cost, contains few parts, and keeps the medicament itself and the needle in a wholly sterile condition up to the moment of use, and at the same time it ensures that during the use substantially the whole of the contents are injected subcutaneously, i.e. only when the needle has achieved the desired penetration.
- the liner 2 is made of glass, instead of plastics, and is shrink wrapped in a PVC sleeve 20. This makes the liner stronger, less fragile, and less likely to notch or scratch. Even if the glass sleeve should fracture the PVC sleeve maintains its structural integrity.
- the head of the collet 6 (referenced as No. 21) is received in the liner 2 prior to firing of the injector, and engages the inside walls of the liner 2. This ensures accurate alignment of the collet and liner during assembly of the injector and avoids any jarring impact on the liner should the collet hit the rearward end of the liner (which may sometimes occur in the embodiment of Figure 1) .
- the second piston 11 and the mounting of the needle 13 relative to it are also different.
- the embodiment of Figure 3 has a similar arrangement and shows the detail more clearly.
- the needle 13 is a double-ended needle having sharp points at each end and has a needle guide 22 such as a disc (perforated) , cross, or the like swaged to it.
- the needle guide 22 mainly serves to transmit drive from the piston 11 to the needle 13, but also centres and guides the needle 13.
- the piston 11 has a stopped central bore 23 at its forward face and a membrane 24 at its rear face.
- a needle holder, or guide 25, is received in the bore 23 and holds the needle 13 and protects the membrane 24 from the needle.
- the end cap 17 has a membrane 27 closing the hole 17', and the guide seal 18 also has a membrane, membrane 28, closing its forward end.
- the membranes 27 and/or 28 may be omitted.
- the medicament does not contact the needle 13 until the injector is fired, and even then the medicament can be dispensed only after substantially all of the air in the injector forward of the piston 11 has been expelled out of the front of the injector.
- the bush 16 and guide valve 18 of the injector of Figure 2 operate in the same way as those of Figure 1.
- cylindrical seal portion 18' of the guide 18 has a relatively tight sealing fit on the needle 13, but does not seal so tightly that air cannot be forced out of the injector between the cylindrical portion 18 and the needle during firing.
- the cylindrical portion 18 ' may seal the unactuated injector against the ingress of atmospheric air past the needle, or it may not - the membrane 15 being sufficient.
- the way of mounting the needle to the second plunger may be a separate invention.
- FIG. 4 Another automatic injector is shown in Figure 4 in which the needle guide 18 is movable relative to the bush 16 during the initial firing of the injector.
- the bush 16 has a stopped internal bore 40 which communicates with an annular space 41 surrounding the forward end of the bush via a channel 42 in the bush.
- the channel 42 has an enlarged radially inner end 43.
- the annular space 41 communicates with atmosphere via the less than airtight attachment of the end cap 17 to the body 1.
- Air escape grooves such as groove 31 of the embodiment of Figure 3, may be provided to facilitate the escape of air.
- the parallel cylindrical sections of the needle guide 18 and bush 16 contact each other so as to form a sterile seal.
- the friction of the needle in the needle guide 18 moves the needle guide 18 forward.
- the guide 18 is pushed fully into the bore 40.
- the groove 44 then communicates with end 43 of the channel 42 and air in the needle chamber has an easy escape route past the radially outer edges of the guide 18, through groove 44 and channel 42, and out between the end cap 17 and the body 1.
- Air can also leave the needle chamber between the needle guide and the needle, via hole or recess 17' (either directly out of the hole 17' after it has been formed by the needle, or out along the interface between the end cap and body) .
- the needle guide 18 may be grooved on its internal surface, adjacent the needle 13.
- the bush 16 may have grooves on its internal surface.
- the automatic injector of Figure 6 has a bush 16 which has a flexible, weakened, region 60 which in effect serves as a sealing lip.
- the bush 16 also has a radial passageway or groove 61 in the region of the weakened region 60.
- the wall of the bush 16 at the weakened region 60 is spaced slightly from the liner 2 at its rearmost end.
- the bush 16 Prior to use the bush 16 seals around the liner 2 to form a sterile seal. Upon firing of the injector the increase of air pressure in the needle chamber distorts the bush at the weakened region 60, allowing the air to pass between the region 60 and the liner 2. The air enters air escape groove or grooves 31 in the end cap 17 via the groove 61.
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/087,804 US5391151A (en) | 1991-01-15 | 1992-01-14 | Subcutaneous injector |
EP92902159A EP0567483B1 (en) | 1991-01-15 | 1992-01-14 | Subcutaneous injector |
DE69220210T DE69220210T2 (en) | 1991-01-15 | 1992-01-14 | SUBCUTANEOUS INJECTION SYRINGE |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9100819.3 | 1991-01-15 | ||
GB919100819A GB9100819D0 (en) | 1991-01-15 | 1991-01-15 | Subcutaneous injector |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1992012745A1 true WO1992012745A1 (en) | 1992-08-06 |
Family
ID=10688450
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1992/000081 WO1992012745A1 (en) | 1991-01-15 | 1992-01-14 | Subcutaneous injector |
Country Status (11)
Country | Link |
---|---|
US (1) | US5391151A (en) |
EP (1) | EP0567483B1 (en) |
AT (1) | ATE153863T1 (en) |
AU (1) | AU1161892A (en) |
CA (1) | CA2100561A1 (en) |
DE (1) | DE69220210T2 (en) |
DK (1) | DK0567483T3 (en) |
ES (1) | ES2102489T3 (en) |
GB (1) | GB9100819D0 (en) |
IE (1) | IE920108A1 (en) |
WO (1) | WO1992012745A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5480381A (en) * | 1991-08-23 | 1996-01-02 | Weston Medical Limited | Needle-less injector |
EP0732950A1 (en) * | 1993-12-07 | 1996-09-25 | Survival Technology, Inc. | Injection device having polyparaxylylene coated container |
EP2974758A1 (en) * | 2014-07-15 | 2016-01-20 | LTS LOHMANN Therapie-Systeme AG | Cylinder-piston unit with cannulas |
Families Citing this family (166)
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- 1992-01-14 US US08/087,804 patent/US5391151A/en not_active Expired - Lifetime
- 1992-01-14 DK DK92902159.0T patent/DK0567483T3/en active
- 1992-01-14 CA CA002100561A patent/CA2100561A1/en not_active Abandoned
- 1992-01-14 EP EP92902159A patent/EP0567483B1/en not_active Expired - Lifetime
- 1992-01-14 IE IE010892A patent/IE920108A1/en unknown
- 1992-01-14 AU AU11618/92A patent/AU1161892A/en not_active Abandoned
- 1992-01-14 DE DE69220210T patent/DE69220210T2/en not_active Expired - Fee Related
- 1992-01-14 AT AT92902159T patent/ATE153863T1/en not_active IP Right Cessation
- 1992-01-14 WO PCT/GB1992/000081 patent/WO1992012745A1/en active IP Right Grant
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Publication number | Priority date | Publication date | Assignee | Title |
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US5480381A (en) * | 1991-08-23 | 1996-01-02 | Weston Medical Limited | Needle-less injector |
EP0732950A1 (en) * | 1993-12-07 | 1996-09-25 | Survival Technology, Inc. | Injection device having polyparaxylylene coated container |
EP0732950A4 (en) * | 1993-12-07 | 1997-06-18 | Survival Technology | Injection device having polyparaxylylene coated container |
EP2974758A1 (en) * | 2014-07-15 | 2016-01-20 | LTS LOHMANN Therapie-Systeme AG | Cylinder-piston unit with cannulas |
WO2016008845A1 (en) * | 2014-07-15 | 2016-01-21 | Lts Lohmann Therapie-Systeme Ag | Cylinder-piston unit comprising cannulas |
Also Published As
Publication number | Publication date |
---|---|
ES2102489T3 (en) | 1997-08-01 |
DK0567483T3 (en) | 1997-12-29 |
US5391151A (en) | 1995-02-21 |
DE69220210D1 (en) | 1997-07-10 |
CA2100561A1 (en) | 1992-07-16 |
AU1161892A (en) | 1992-08-27 |
EP0567483B1 (en) | 1997-06-04 |
EP0567483A1 (en) | 1993-11-03 |
DE69220210T2 (en) | 1997-10-02 |
GB9100819D0 (en) | 1991-02-27 |
IE920108A1 (en) | 1992-07-15 |
ATE153863T1 (en) | 1997-06-15 |
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