WO1992010999A1 - Substance that can stop bleeding in surgical, medical and dental uses/substance powder 001 that can stop bleeding during surgery, after surgery, medicine, dentistry or any bleeding due to any causes - Google Patents

Abstract

A method for stopping bleeding is described. The method entails applying to the site of bleeding powdered Vitamin C.

Description

SUBSTANCE THAT CAN STOP BLEEDING IN SURGICAL, MEDICAL AND DENTAL

USES/SUBSTANCE POWDER 001 THAT CAN STOP BLEEDING DURING SURGERY,

AFTER SURGERY, MEDECINE, DENTISTRY OR ANY BLEEDING DUE TO ANY CAUSES

SPECIFICATION OF INVENTION

(a) Title of the Invention.

The substance powder 001 that can stop (stanch) bleeding in surgical, postsurgical, medical and dental uses or any bleeding due to any causes by topical administration or the substance powder 001 that has very potent hemostatic action can be administered topically to stop bleeding during surgery, after surgery, medicine by ingestion, dental surgery, extraction of teeth, and any injury or due to any causes for any normal and pathological persons.

(b) Cross-References to Related Applications.

The early literature on scurvy due to vitamin C deficiency was reviewed by Bourne in 1944, he showed hieroglyphs from Egyptian papyri as convincing evidence that this disease, charaterized by bleeding gums and hemorrhages in the skin, existed about 3000 years ago. A sudden pain seized their feet, and legs;

immediately afterwards the gums and teeth were attacked by a sort of gangrene. The bones of the legs become horribly black. The legs shrivelled up and became covered with black spots. It was a sure sign of death when the nose began to bleed. ( Bourne, G,H, 1944, Proc. R. Soc. Med., 37, 512 ) PATNAIK 1971 stated that the concentration of ascorbio acid has been reported as decreasingwith age in the rat eye lens, adrenal, brain, testis, and blood. ( Patnaik, B.K. 1971,

Gerontologia, 17, 122 ) Purpura (extensive bruising ) and hemorrhages under the tongue are common in elderly people.

Tattersal and Seville 1950 reported purpura in 60 out of 809 elderly patients admitted to hospital; the bruises were most commonly seen on the anterior aspects of their arms and forearms. and on the backs of their hands, noth patients. and the controls were ascorbate deficient, as judged by ascorbic acid loading tests; skin biopsies from those with purpura showed degeneration of the collagen fibres of the dermis. Tattersall (c) Background of the Invention.

(1) THIS invention pertains to the field of disorder of hemostasis, which is further classified into evaluation of hemostatic function, platelet disorders, coagulation factor disorders and thromboembolic disorders. However, the blood coagulation mechanism of ascorbi c acid which was administered topically does not fall into either

intrinsic or extrinsic pathway cascade, since it works the same for hemostasis in normal situation as in chronic- hepatitis, colon cancer, and hemophilia patients in

whom the coagulation factors 2, 7, 9, 10 in the l iver disease and factor 8 or 9 in the hemophilia A or B cannot be produced. (2) The present methods available to stop bleeding in surgery are cautery, epinephrine injection, pressure and some fiber foam. The cautery can cause tissue necrosis in

some cases. The epinephrine, pressure and fiber foam can not work for bleeding tendency patients, and fiber foam can cause tissue hemotoma, nor can they work for diffuse capillary bleeding and oozing, while ascorbic acid does not cause any tissue necrosis and works particularly w el l for diffuse capillary bleeding and any traditionally uncontrollable bleeding tendency patients such as for patients with liver diseases, hemophilia and rectal anal cancer and for postoperation bleeding tendency of the kinds of aforementioned patients. The ascorbic acid can facilitate wound healing also ( Oral Surg 1982 Mar: 53(3): 231-6 ) by increasing type 1 procollagen mRNA in the regulation of col l agen synthesis ( Atherosclerosis 1982 Jan: 41(1): 15-9 ) (d) Explanation of Invention / Summary.

Substance powder 001 represents ascorbic acid powder that is obtained by grinding the vitamin C tablets into powder. This powder has a very potent hemostatic action to stop bleeding when spraying it topically on the bleeding a rea for any

normal or any diseased pa t ient s . When t he powder come s i n contact with the blood, the black tar gel like material is formed, and later becomes solid. The amount of the powder that is

needed to react completely with the blood is proportional

to the amount of the blood that comes out of the blood

vessels. In rats, one capillary, one venous and one femoral artery bleeding were stanched within one second, if sufficient amounts of the powder of ascorbic acid were applied. The artery bleeding needs much more this powder of interest. In the test tube conditions, it requires 0.1568 g of this substance powder to coagulate ( make the blood black and not move in the tube ) 1 ml of human blood in 6 minutes. This is the same for normal, colon cancer and hemophilia patients; 1 ml of normal blood

needs 0.1568 g of ascorbic acid powder, 1 ml of colon cancer blood needs 0.1568 g of ascorbic acid powder, and 1 ml of

hemophilia blood needs 0.1568 g of ascorbic acid powder. Sufficient substance powder 001 is particularly useful to help stop bleeding in the case of diffuse capillary oozing and mistakenly cut off artery or arteries that cannot be found during massive bleeding bleeding so as to save the patients' lives.

The present methods available to stop bleeding in surgery as previously mentioned are cautery, epinephrine injection, pressure and some fiber foam. The cautery can cause tissue necrosis in some cases. The epinephrine, pressure and fiber foam can not cannot work for bleeding tendency and diffuse capi l l ary oozing patients, while ascorbic acid powder does not cause any tissue necrosis and particularly works well for diffuse capillary bleeding and oozing and any traditionally uncontrollable bleeding tendency patients such as for patients with liver diseases, hemophilia and colon rectal or other cancer bleeding conditions and for postoperation bleeding tendency of the kinds of aformentioned patients. The ascorbic acid also facilitate wound healing ( Oral Surg. 1982 Mar: 53 (3): 231-6 ) by increasing type 1 procollagen mRNA in the regulation of collagen synthesis ( Atherosclerosis 1982 Jan: 41(1): 15-9 ) and when the vitamin C is absorbed into the system, it is good for health by making the leucocytes stronger and slowing the aging process etc, ( Patnaik and Kanungo 1964, Gerontologia, 10, 155 ) as long as it is within the optimal dose such as 1 g, However, at the end of operation before closure, the excessive black tar gel like material can be wiped away

and washed with Ringer's solution.

( e) Description of the preferred embodiments of the invention:

As already mentioned previously, the substance powder 001 is made by grinding the pure vitamin C tablets into powder.

Application of this powder topically to the bleeding area is better by spraying the powder topically on the bleeding area.

The amount of vitamin C powder needed to spray is proportional to the amount of blood coming out of the vessels. In test tube conditions, it requires 0.1568 g of this vitamin C powder to coagulate 1 ml of human blood. This is the same for normal, liver diseases, cancer, and hemophilia patients. The black coagulation takes place in 6 minutes by shaking the test tube. The description of this situation is made in the evidence of animal ( rats ) experiments and clinical evidence as follows:

(f) Rats Experiments

1) Sufficient substance powder 001 can stop massive bleeding of femoral artery within one second when femoral artery is cut off. ( Photograph # 1 : massive bleeding when the femoral artery is cut off ) ( Photogrph # 2: bleeding stops within one second when sufficient powder of interest was poured topically into

the bleeding area, in this case of massive active bleeding I did pouring instead of spraying. The amount of the powder needed is proportional to the amount of blood coming out of the vessel.

It varies with the rats. Usually 0.1344 g is sufficient to stop bleeding for the femoral artery of the rat which is cut off within one second. In the photograph # 2, the black tar gel like material was formed in one second as soon as the powder contacts with the blood . Those white spots indicate the powder that is not yet mixed up with the blood. The black gel forms first on the surface of the pond of blood, that stop the fluid moving. If stirring the blood to break through the surface film like structure that keep the blood fluid from moving when the powder is insufficien it will bleed again, but slower than ( much slower ) before

pouring the powder into the bleeding area; but after adding

sufficient powder into the blood, stirring makes the powder

molecules well saturated with the hemoglobin and plasma proteins molecules and thus forming the concentrated black sticky gel like structure. After 5-6 minutes, when most of the sticky tar like structure is wiped away, it appears there is no bleeding at

all. ( Photograph # 3 ). In the case of capillary bleeding

in which one capillary is cut off, about 0. 0112 g of this

powder can stop the bleeding within one second, ( Photograph #

4 ). After 1 minute count from adding the powder, it appears there is no more bleeding while wiping away the black tar gel like structure, while in the case of one vein cut of f , i t needs abou t 0.0224 g of the powder to stop bleed i ng , and about after 1 1/2 minutes, it appears there is no more bleeding when the black coagulation is wiped away. ( Photograph # 5 ).

The nostril was cut slightly to bleed ( Photograph # 6 ) in rat, the bleeding stop within one second when applying this powder

0.0037 g topically into the bleeding nostril, ( Photograph #

7 ). After injection of histamin into the rat, it induces

secretion of gastric acid, open up the stomach ( Photograph #

8 ), cut the mucosa layer to bleed ( Photograph # 9 ), applying the powder topically to the bleeding area, the black coagulation formed, but slower than normal, since the secretion dilute the black coagulation. ( Photograph # 10) Thus this powder can

treat the gastric ulcer bleeding when it is ingested orally. Clinical Evidence.

This powder also help stop massive bleeding in surgery, no matter what kind of diseases the patients suffered from.

Case 1. Age 32, male, scalp tumor excision, massive bleeding

when the tumor vas excised. ( Photograph # 11 ) Sufficiently spraying this powder into the bleeding area also help stop bleeding before it was closed by suture. ( Photograph # 12 )

Case 2. Age 40, female, acute renal failure, A-V fistula formation operation, massive bleeding ( Photograph * 13 )

The operation of stopping bleeding consists of combining the powder with press with gauze. When applying this powder to the bleeding area, those that look black in color indicate the black blood coagulation ( Photograph # 14), while those that are white in color are those the powder does not get mixed up with the blood ( Photograph # 15). At the end of the operation, most of black blood coagulation was wiped out with 4x4 gauze, and rinsed with Ringer's solution ( Photograph # 16 ). It took totally 5 minutes to stop the bleeding completely. The patient's conditions are especially well, better than without using this powder.

Case 3. Age 40, male, skin contracture on the palm, which needs

to be removed, and it requires skin graft.

When the skin graft is removed from the hand,massive bleeding occurs ( Photograph # 17) . On applying sufficient powder to the bleeding area topically, it appears black coagulation within one second. Bleeding stops nt the same time ac the black coagulation forms. Those that appears white indicate the powder not yet mixed up with the blood. ( Photograph 4 18); those that appears more black area indicate the more powder mixed up with the blood (Photograph # 19), Suture going on ( Photograph # 20 ) Case 4. Age 70, female, paraanal abscess excision, bleeding when it is opened up ( Photograph # 21 ). When spraying the powder to the bleeding area, it stop bleeding by forming black blood coagulation immediately. Those that appears white are the powder that are not mixed up with the blood. ( Photograph # 212), Suture going on ( Photograph # 23 ).

Case 5. Age 50, male, paraanal abscess excision.

maasive bleeding when it is opened up ( Photograph # 24 ). On spraying the powder topically to the bleeding area, the black color is formed immediately because of the blood coagulation ( Photograph # 25 ) . The white color is the powder instantly not mixed up with the blood yet. ( Photograph # 25 ), lastly, insert the long gauze into the anus. ( Photograph # 27 )

Case 6. Age 30, male, extraction of tooth, the gum injected bleeds

( Photograph # 28 ). Applying this powder topically to the bleeding area, the bleeding stop within one second and black blood coagulation forms within one second

( Photograph # 29 ) . Wipe out the black coagulation in 10 seconds, stop bleeding still persisted ( Photograph # 30 )

Case 7. Age 60, female, chronic hepatitis, has bleeding tendency, extraction of teeth cause massive bleeding ( Photograph # 31 ) On applying this powder to the socket of the gum, the black coagulation forms within one second, the bleeding of Ihis socket stops within one second accordingly.

( Photograph # 32 )

Case 8. myself, finger little scratched, slightly bleeds

( Photograph # 33 ). Upon contact with the powder, the black color forms within one second or shorter ( Photo In test, tube condition as mentioned previously, 1 ml of human

blood requires 0.1568 g of powder to form black blood coagulation by shaking the tube with hand or stirer machine.

It takes 6 minutes to form the unmobile black coagulation

in the test tube for normal, liver diseases, colon cancer

and hemophilia blood respectively. ( Photograph # 35 normal

blood, colon cancer Photograph # 36, and hemophilia blood

Photograph # 37 ) This indicates that the mechanism of

the coagulation by this powder does not involve the coagulation

factors. The hemophilia blood ( both prior to adding the powder

and after adding powder) are still stored in the freezer here.

This patient's name: Su Jean Wang, Age 25, male, D.I.

# S 121745233, address: No 5, Su Ming Rd., Lane 100

Nan Tze District, Kaohsiung City , lastly, Stops bleeding in tonsillectomy rat within one second by topical use of this (f). Claims of Utilities of ascorbic acid powder.

1. Stops bleeding in the nose bleeding in humans w i thin one

second, experienced in my 6 years old daughter by applying

this powder topically in to her bleeding nostril.

2 . Stops bleeding in any ijury due to any cause, this also be

useful for wound bleeding in the war or combat zone.

3. Stops bleeding in bleeding tendency patients in surgery

or after surgery. Help stop bleeding in A-V fistula formation

surgery in preparation for hemodialysis.

4. Stops bleeding in massive bleeding in scalp tumor excision.

5. Stops bleeding in bleeding tendency in paranal abscess

oxcision.

6. Stops bleeding in postoperation ( after surgery ) bleeding

in perineum wound bleeding after rectal anal cancer surgery.

7. Stops bleeding in teeth extraction within one second in

bleeding tendency patients when applying this powder topically

to the bleeding socket of the gum.

8. Stops bleeding in the hemophilia patients due to injury when

applying the powder topically to bleeding area sufficiently.

9. Stops bleeding in Ob & Gyn surgery in bleeding tendency

Claims

patients when applying this powder sufficiently to the

bleeding area.

10. Stops bleeding due to injury or bleeding due to any causes.

11. Stops gastric ulcer bleeding when ingestion of this powder about 1 g / day orally.

12. Help stop and prevent internal bleeding when taking

1 g of this powder daily orally.

13. Stops bleeding and help stop bleeding in tonsillectomy

and

and after tonsillectomy bleeding. 14. The ascorbic acid powder is

obtained by grinding the

v itami n C tablets into powder