WO1991018614A1 - Method for the treatment of aging or photo-damaged skin - Google Patents
Method for the treatment of aging or photo-damaged skin Download PDFInfo
- Publication number
- WO1991018614A1 WO1991018614A1 PCT/US1990/002976 US9002976W WO9118614A1 WO 1991018614 A1 WO1991018614 A1 WO 1991018614A1 US 9002976 W US9002976 W US 9002976W WO 9118614 A1 WO9118614 A1 WO 9118614A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- aging
- skin
- photo
- treatment
- composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Definitions
- the present invention relates to a composition for improving the appearance of skin affected by natural aging processes and by similar processes accelerated by overexposure to solar radiation. More particularly, this invention relates to a topical formulation which has been found effective to reduce localized furrows (wrinkles) in the epidermis.
- Skin is composed of a top layer, the epidermis, which is approximately 20 cell layers or about 0.1mm thick, and a lower layer, the dermis, which is from about 1 to about 4mm thick and contains small blood vessels, collagen, elastin and fibroblasts.
- the dermis provides structural support and nutrients to the epidermis. While aging has been shown to increase cellular heterogeneity of the epidermal layer, it has little effect on the thickness of that layer.
- the supporting dermis is known to thin with age and sun exposure. Since the dermal layer provides the support and blood supply for the epidermis, it is of critical importance in maintaining the elasticity and appearance of the skin. Disruption of the supporting dermis layer leads directly to sagging and consequent furrowing of the epidermis, i.e., the formation of wrinkles.
- Deep wrinkles are due to continual stretching and contraction of both the dermis and epidermis, and such deep furrows can only be eliminated by plastic surgery or by collagen injections directly beneath the depressed areas.
- fine wrinkles which occur with age (and repeated prolonged exposure to the sun) on skin areas which are less stretched during use are the direct result of deterioration of the supporting dermal layer.
- Collagen exists normally in dense, organized patterns. During the aging process it becomes disorganized and less supportive of the epidermis.
- elastin is lost from the dermis, and there is a progressive loss of circulatory support from the small blood vessels which are more numerous and close to the surface in young skin.
- Dermatologists and cosmetologists alike have directed their efforts to improving the appearance of skin interrupted by time-telling wrinkles.
- One much explored approach has been treatment with agents known to stimulate the growth and proliferation of epidermal cells. Because newly proliferated cells provide more structure and hold more moisture, the skin takes on a younger appearance. This has been accomplished by use of an irritant or chemical peel. The uppermost layers of the epidermis are caused to slough off and be replaced with new epidermal cells. While such treatment is recognized to provide some cosmetic improvement, it does not address the major causative factor - the compromised supporting dermal layer.
- the present invention is directed to a treatment for sun damaged or aged skin which targets the cells of the supporting dermal layer.
- a composition of ascorbic acid, tyrosine and a non-toxic zinc salt, preferably zinc sulfate in a vehicle suitable for topical application, when applied to areas showing the fine wrinkles associated with aging/sun exposure, results in a readily perceivable dimunition of the fine wrinkle structure. While the mode of action of the present composition is not wholly understood, it is believed that the ingredients cooperate to stimulate fibroblast proliferation and to promote their production of collagen and elastin, thereby promoting the supporting role of the associated dermal tissues.
- This invention differs from the most prominent current treatment of aged/photo-aged skin, that is, topical treatment with tretinoin (Retin-A) .
- Tretinoin stimulates epidermal cells, but does not result in any observable changes in the dermis [Weiss, JAMA, p. 531 (1988)].
- Tretinoin apparently increases epidermal turnover time by stimulating the growth of those cells which are not normally shed as often as younger skin.
- the increased proliferation of epidermal cells by tretinoin has been shown to improve the appearance of skin having age-induced wrinkles, it does not compensate for the age-related losses of melanocytes which exist in the epidermis.
- the increased proliferation of the epidermal cells may lead to more rapid loss of melanocytes and such is known to be associated with increasing susceptibility to sun damage. Therefore, individuals utilizing the tretinoin treatment must take great care to avoid unnecessary exposure to the sun.
- the present invention is directed to a composition for topical application to reduce epidermal wrinkling resulting from intrinsic aging or photo-aging.
- the composition comprises from about 2 to about 20%, more preferably about 5 to about 15% ascorbic acid, about 1 to about 10%, more preferably 3 to about 8% tyrosine, and about 0.5 to about 5%, more preferably from about 1 to about 2%, zinc sulfate.
- Those components are preferably blended into a tissue compatible vehicle, such as hydrophilic lotion-, ointment-, cream- or gel-based vehicle.
- Such pharmaceutically acceptable vehicles are well known in the art and commercially available for formulation of active ingredients into a suitable form for topical application. Exemplary of such vehicles are the commercially available Dermabase and Unibase formulations.
- An essential ingredient in the present composition is a non-toxic, water soluble zinc salt, preferably zinc sulfate. Without zinc sulfate in the present formulation, we have found no beneficial effect. Although it has been observed that aged persons who develop abnormal skin conditions may be deficient in zinc, recent studies suggest that the apparent low serum zinc was actually due to decreased serum albumin, the carrier protein for zinc, and not a zinc deficiency itself. No improvement was noted in patients receiving supplemental zinc, even though elevated plasma zinc was detected.
- the present topical preparation was formulated with 3% zinc sulfate and used daily by five female subjects, aged between 45 and 70.
- One subject discontinued use of the test formulation during the study due to skin irritation. That subject was later maintained on a similar formulation containing only 1% zinc sulfate. All five subjects noted slight improvement in fine wrinkles within a week, particularly those around the mouth. After three months' use, the four subjects who continued participation in the trial, all reported excellent results.
- test formulation was prepared by blending the ingredients shown in Table 1 in the indicated proportions.
- a control cream was prepared with the same ingredients except without tyrosine and ascorbic acid.
- One or two independent cosmetologists recorded the location of a fine wrinkle or wrinkle pattern for each of 50 female subjects.
- Each participant in the study was instructed to utilize the cream sparingly and apply it only to the wrinkled area of the skin to be treated and not to their whole face.
- the participants were told that the formulation can be applied to the forehead, and the areas around the mouth and chin, but that the area immediately under the eyes should be avoided.
- the participants were also told that should they experience an uncomfortable tingling or sensation lasting more than a few minutes following application of the cream that they should apply a very light moisturizer cream before application of the test substance.
- the subjects were also informed that the cream should be applied morning and night.
- the subjects were randomly given one of the two cream samples to use twice daily for four weeks.
Abstract
Description
Claims
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK90909965.7T DK0533667T3 (en) | 1988-11-14 | 1990-05-25 | Procedure for treating aging or photo-damaged skin |
JP50981190A JP2988491B2 (en) | 1988-11-14 | 1990-05-25 | How to treat aging or light damaged skin |
ES90909965T ES2073577T3 (en) | 1988-11-14 | 1990-05-25 | METHOD FOR TREATING LIGHT AGED OR DAMAGED SKIN, BACKGROUND AND SUMMARY OF THE INVENTION. |
HU9203683A HU215931B (en) | 1988-11-14 | 1990-05-25 | Process for producing topical composition for diminishing wrinkles |
MC90@@D MC2286A1 (en) | 1988-11-14 | 1990-05-25 | PROCESS FOR TREATING DAMAGED SKIN BY AGING OR LIGHT |
RU9092016359A RU2086231C1 (en) | 1988-11-14 | 1990-05-25 | Method for diminishing depth of wrinkles on patient's skin |
CA002063610A CA2063610C (en) | 1988-11-14 | 1990-05-25 | Method for the treatment of aging or photo-damaged skin |
EP90909965A EP0533667B1 (en) | 1988-11-14 | 1990-05-25 | Method for the treatment of aging or photo-damaged skin |
AU59230/90A AU649618B2 (en) | 1988-11-14 | 1990-05-25 | Method for the treatment of aging or photo-damaged skin |
BR909008018A BR9008018A (en) | 1988-11-14 | 1990-05-25 | PROCESS FOR TREATING AGED OR PHOTO-DAMAGED SKIN |
AT90909965T ATE124263T1 (en) | 1988-11-14 | 1990-05-25 | METHOD FOR TREATING AGING OR PHOTODAMAGE TO THE SKIN. |
DE69020584T DE69020584T2 (en) | 1988-11-14 | 1990-05-25 | METHOD FOR TREATING AGING OR LIGHT DAMAGE TO THE SKIN. |
FI925190A FI102589B (en) | 1988-11-14 | 1992-11-16 | Composition for care of aging or light damaged skin |
NO1992924457A NO924457D0 (en) | 1988-11-14 | 1992-11-19 | PROCEDURE FOR THE PREPARATION OF MIXTURES FOR TREATMENT OF WRINKLE SKIN |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/271,213 US4938969A (en) | 1988-11-14 | 1988-11-14 | Method for the treatment of aging or photo-damaged skin |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1991018614A1 true WO1991018614A1 (en) | 1991-12-12 |
Family
ID=23034664
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1990/002976 WO1991018614A1 (en) | 1988-11-14 | 1990-05-25 | Method for the treatment of aging or photo-damaged skin |
Country Status (15)
Country | Link |
---|---|
US (1) | US4938969A (en) |
EP (1) | EP0533667B1 (en) |
JP (1) | JP2988491B2 (en) |
AT (1) | ATE124263T1 (en) |
AU (1) | AU649618B2 (en) |
BR (1) | BR9008018A (en) |
CA (1) | CA2063610C (en) |
DE (1) | DE69020584T2 (en) |
DK (1) | DK0533667T3 (en) |
ES (1) | ES2073577T3 (en) |
FI (1) | FI102589B (en) |
MC (1) | MC2286A1 (en) |
NO (1) | NO924457D0 (en) |
RU (1) | RU2086231C1 (en) |
WO (1) | WO1991018614A1 (en) |
Cited By (1)
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---|---|---|---|---|
WO2000056278A1 (en) * | 1999-03-24 | 2000-09-28 | La Roche Posay Laboratoire Pharmaceutique | Use of vitamin c or the like for stimulating skin cell synthesis |
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US4938969A (en) * | 1988-11-14 | 1990-07-03 | Milor Scientific, Ltd. | Method for the treatment of aging or photo-damaged skin |
US5140043A (en) * | 1989-04-17 | 1992-08-18 | Duke University | Stable ascorbic acid compositions |
US5624675A (en) * | 1989-06-06 | 1997-04-29 | Kelly; Patrick D. | Genital lubricants containing zinc salts to reduce risk of HIV infection |
US5376361A (en) * | 1993-01-13 | 1994-12-27 | Perricone; Nicholas V. | Method and compositions for topical application to the skin for prevention and/or treatment of radiation-induced skin damage |
US5935584A (en) * | 1994-01-13 | 1999-08-10 | Elizabeth Arden Company | Vitamin C delivery system |
US5470874A (en) * | 1994-10-14 | 1995-11-28 | Lerner; Sheldon | Ascorbic acid and proanthocyanidine composition for topical application to human skin |
US5643586A (en) * | 1995-04-27 | 1997-07-01 | Perricone; Nicholas V. | Topical compositions and methods for treatment of skin damage and aging using catecholamines and related compounds |
FR2737971B1 (en) * | 1995-08-25 | 1997-11-14 | Lvmh Rech | USE OF VITAMIN C OR DERIVATIVES OR THE LIKE TO STIMULATE SKIN ELASTINE SYNTHESIS |
US5879690A (en) * | 1995-09-07 | 1999-03-09 | Perricone; Nicholas V. | Topical administration of catecholamines and related compounds to subcutaneous muscle tissue using percutaneous penetration enhancers |
US5827884A (en) * | 1995-09-15 | 1998-10-27 | Omp Acquisition Corporation | Skin peel maintenance composition and method |
FR2740335B1 (en) * | 1995-10-26 | 1997-12-19 | Oreal | USE OF LANTHANIDE, LITHIUM, TIN, ZINC, MANGANESE OR YTTRIUM SALT AS A SUBSTANCE P ANTAGONIST |
US5843411A (en) * | 1997-02-06 | 1998-12-01 | Topix Pharmaceuticals Inc. | Stabilization of ascorbic acid, ascorbic acid derivatives and/or extracts containing ascorbic acid for topical use |
FR2779059B1 (en) * | 1998-05-29 | 2004-09-10 | Guerlain | COSMETIC TREATMENT PROCESS FOR COMBATING THE EFFECTS OF CUTANEOUS AGING; NEW COSMETIC COMPOSITIONS FOR ITS IMPLEMENTATION |
US6471972B1 (en) | 1996-11-07 | 2002-10-29 | Lvmh Recherche | Cosmetic treatment method for fighting against skin ageing effects |
US5804594A (en) * | 1997-01-22 | 1998-09-08 | Murad; Howard | Pharmaceutical compositions and methods for improving wrinkles and other skin conditions |
US6124348A (en) * | 1997-07-01 | 2000-09-26 | Lawrence M. Wells | Vitamin C skin formulations |
US6194452B1 (en) | 1997-11-07 | 2001-02-27 | Howard Murad | Stable pharmaceutical compositions including ascorbic acid and methods of using same |
US6110966A (en) * | 1998-02-20 | 2000-08-29 | Medi-Cell Laboratories, Inc. | Triple action complex |
US6110477A (en) * | 1998-10-30 | 2000-08-29 | Topix Pharmaceuticals Inc. | Stabilization of ascorbic acid, ascorbic acid derivatives and/or extracts containing ascorbic acid for topical use |
US7816402B2 (en) | 1999-03-19 | 2010-10-19 | Bioderm, Inc. | Compositions and methods for the treatment of skin |
US6217914B1 (en) | 1999-03-19 | 2001-04-17 | Bioderm, Inc. | Ascorbic acid composition and method for treatment of aging or damaged skin |
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US20070178058A1 (en) * | 2006-02-02 | 2007-08-02 | Ramirez Jose E | Methods of using stable ascorbic acid compositions |
US20070269534A1 (en) * | 2006-02-02 | 2007-11-22 | Ramirez Jose E | Methods of treating skin to enhance therapeutic treatment thereof |
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US8952057B2 (en) | 2011-01-11 | 2015-02-10 | Jr Chem, Llc | Compositions for anorectal use and methods for treating anorectal disorders |
KR101989666B1 (en) | 2017-03-24 | 2019-06-17 | (주)셀아이콘랩 | Cosmetic composition that prevents aging and improves wrinkles by containing novel heptapeptide monomer and dimer |
KR102140652B1 (en) | 2019-12-06 | 2020-08-03 | (주)이시스코스메틱 | Composition Comprising Vitamin C |
WO2022124386A1 (en) * | 2020-12-07 | 2022-06-16 | L' Oreal | Composition comprising ascorbic acid and cyclic amino acid |
FR3118710A1 (en) * | 2021-01-11 | 2022-07-15 | L'oreal | COMPOSITION COMPRISING ASCORBIC ACID AND CYCLIC AMINO ACID |
JP2023167026A (en) * | 2022-05-11 | 2023-11-24 | 克昭 團 | Pancreatic function activating agent, anti-aging agent, therapeutic or prophylactic agent for type-2 diabetes, medicine, cosmetic, and food or beverage |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4704280A (en) * | 1986-12-19 | 1987-11-03 | Bates Harry L | Cosmetic lotion |
US4743442A (en) * | 1983-08-02 | 1988-05-10 | Blendax-Werke R. Schneider Gmbh & Co. | Skin care composition |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2543437B1 (en) * | 1983-03-30 | 1987-07-10 | Duraffourd Alain | COMPOSITION FOR REGENERATING COLLAGEN OF CONNECTIVE TISSUE OF THE SKIN AND METHOD FOR PREPARING SAME |
CA1291034C (en) * | 1987-10-19 | 1991-10-22 | Mostafa S. Fahim | Composition for promoting epithelial regeneration |
US4938969A (en) * | 1988-11-14 | 1990-07-03 | Milor Scientific, Ltd. | Method for the treatment of aging or photo-damaged skin |
-
1988
- 1988-11-14 US US07/271,213 patent/US4938969A/en not_active Expired - Lifetime
-
1990
- 1990-05-25 RU RU9092016359A patent/RU2086231C1/en not_active IP Right Cessation
- 1990-05-25 MC MC90@@D patent/MC2286A1/en unknown
- 1990-05-25 CA CA002063610A patent/CA2063610C/en not_active Expired - Lifetime
- 1990-05-25 AU AU59230/90A patent/AU649618B2/en not_active Expired
- 1990-05-25 ES ES90909965T patent/ES2073577T3/en not_active Expired - Lifetime
- 1990-05-25 DE DE69020584T patent/DE69020584T2/en not_active Expired - Lifetime
- 1990-05-25 BR BR909008018A patent/BR9008018A/en not_active IP Right Cessation
- 1990-05-25 JP JP50981190A patent/JP2988491B2/en not_active Expired - Lifetime
- 1990-05-25 DK DK90909965.7T patent/DK0533667T3/en active
- 1990-05-25 AT AT90909965T patent/ATE124263T1/en not_active IP Right Cessation
- 1990-05-25 EP EP90909965A patent/EP0533667B1/en not_active Expired - Lifetime
- 1990-05-25 WO PCT/US1990/002976 patent/WO1991018614A1/en active IP Right Grant
-
1992
- 1992-11-16 FI FI925190A patent/FI102589B/en active
- 1992-11-19 NO NO1992924457A patent/NO924457D0/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4743442A (en) * | 1983-08-02 | 1988-05-10 | Blendax-Werke R. Schneider Gmbh & Co. | Skin care composition |
US4704280A (en) * | 1986-12-19 | 1987-11-03 | Bates Harry L | Cosmetic lotion |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000056278A1 (en) * | 1999-03-24 | 2000-09-28 | La Roche Posay Laboratoire Pharmaceutique | Use of vitamin c or the like for stimulating skin cell synthesis |
FR2791259A1 (en) * | 1999-03-24 | 2000-09-29 | Roche Posay Lab Pharma | USE OF VITAMIN C OR THE LIKE TO INCREASE THE RATE OF DIFFERENTIATION AND / OR PROLIFERATION OF SKIN CELLS |
Also Published As
Publication number | Publication date |
---|---|
DE69020584D1 (en) | 1995-08-03 |
AU649618B2 (en) | 1994-06-02 |
ATE124263T1 (en) | 1995-07-15 |
CA2063610A1 (en) | 1991-11-26 |
MC2286A1 (en) | 1993-07-14 |
RU2086231C1 (en) | 1997-08-10 |
DE69020584T2 (en) | 1995-11-30 |
JPH05506840A (en) | 1993-10-07 |
FI925190A (en) | 1992-11-16 |
EP0533667B1 (en) | 1995-06-28 |
JP2988491B2 (en) | 1999-12-13 |
ES2073577T3 (en) | 1995-08-16 |
BR9008018A (en) | 1993-03-02 |
DK0533667T3 (en) | 1995-11-13 |
US4938969A (en) | 1990-07-03 |
AU5923090A (en) | 1991-12-31 |
NO924457D0 (en) | 1992-11-19 |
EP0533667A1 (en) | 1993-03-31 |
EP0533667A4 (en) | 1993-05-12 |
FI102589B1 (en) | 1999-01-15 |
FI925190A0 (en) | 1992-11-16 |
FI102589B (en) | 1999-01-15 |
CA2063610C (en) | 2001-12-18 |
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