WO1991011172A1 - Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof - Google Patents
Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof Download PDFInfo
- Publication number
- WO1991011172A1 WO1991011172A1 PCT/US1991/000326 US9100326W WO9111172A1 WO 1991011172 A1 WO1991011172 A1 WO 1991011172A1 US 9100326 W US9100326 W US 9100326W WO 9111172 A1 WO9111172 A1 WO 9111172A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- independently
- group
- alkylene
- cyclodextrin
- derivative
- Prior art date
Links
- 0 CCCC(C(*)*1)OC(C*)C1C(C)(*)OC(C(*)N*)OC(CN)C(C*=C)C(C)(C)OC(C(*)*1)OC(C*)C1OCC Chemical compound CCCC(C(*)*1)OC(C*)C1C(C)(*)OC(C(*)N*)OC(CN)C(C*=C)C(C)(C)OC(C(*)*1)OC(C*)C1OCC 0.000 description 2
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/16—Cyclodextrin; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nanotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medical Informatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019920701734A KR0166088B1 (en) | 1990-01-23 | 1990-01-22 | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
DE69130165T DE69130165T2 (en) | 1990-01-23 | 1991-01-22 | CYCLODEXTRIN DERIVATIVES WITH INCREASED WATER-SOLUBILITY AND THEIR USE |
SU925052811A RU2099354C1 (en) | 1990-01-23 | 1991-01-22 | Purified derivative of cyclodextrine, clathrate complex of purified derivative of cyclodextrine with drug, pharmaceutical composition |
CA002074186A CA2074186C (en) | 1990-01-23 | 1991-01-22 | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
EP91903891A EP0512050B1 (en) | 1990-01-23 | 1991-01-22 | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US469,087 | 1990-01-23 | ||
US07/469,087 US5134127A (en) | 1990-01-23 | 1990-01-23 | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1991011172A1 true WO1991011172A1 (en) | 1991-08-08 |
Family
ID=23862363
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1991/000326 WO1991011172A1 (en) | 1990-01-23 | 1991-01-22 | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
Country Status (10)
Country | Link |
---|---|
US (1) | US5134127A (en) |
EP (1) | EP0512050B1 (en) |
JP (1) | JP2722277B2 (en) |
KR (1) | KR0166088B1 (en) |
AT (1) | ATE170742T1 (en) |
AU (1) | AU646020B2 (en) |
CA (1) | CA2074186C (en) |
DE (1) | DE69130165T2 (en) |
RU (1) | RU2099354C1 (en) |
WO (1) | WO1991011172A1 (en) |
Cited By (311)
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DE4204315A1 (en) * | 1992-02-13 | 1993-08-19 | Consortium Elektrochem Ind | CYCLODEXTRINGLYCOSIDES AND METHOD FOR THE PRODUCTION THEREOF |
DE4309579A1 (en) * | 1993-03-24 | 1994-09-29 | Sanol Arznei Schwarz Gmbh | Pharmaceutical composition in the form of a kit |
EP0620828A1 (en) * | 1992-07-27 | 1994-10-26 | The University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
EP0710673A2 (en) | 1990-05-21 | 1996-05-08 | Toppan Printing Co., Ltd. | Cyclodextrin derivatives |
JPH08510232A (en) * | 1993-05-12 | 1996-10-29 | キノイン・ジヨージセル・エーシユ・ベジエーセテイ・テルメーケク・ジヤーラ・エル・テー | Inclusion complex consisting of taxol or taxotere or yew extract and cyclodextrin, production and use of the complex |
WO1996041646A2 (en) * | 1995-06-13 | 1996-12-27 | Dyer, Alison, Margaret | Pharmaceutical compositions containing lornoxicam and cyclodextrin |
EP0796858A1 (en) | 1996-03-19 | 1997-09-24 | Pfizer Limited | Triazole antifungal agents |
EP0867175A1 (en) * | 1997-03-27 | 1998-09-30 | Wacker-Chemie GmbH | Complexes of gamma-cyclodextrins and retinol or retinol-derivatives and manufacturing process thereof and their use |
WO1998050077A1 (en) * | 1997-05-05 | 1998-11-12 | Cydex Inc. | Solid pharmaceutical formulations containing a physical mixture of sulfoalkyl ether cyclodextrin and a therapeutic agent |
WO1998058677A1 (en) * | 1997-06-21 | 1998-12-30 | Pfizer Limited | Pharmaceutical formulations containing voriconazole |
EP0889056A2 (en) * | 1997-07-01 | 1999-01-07 | Pfizer Products Inc. | Process for making a cyclodextrin |
WO2001000243A1 (en) * | 1999-06-29 | 2001-01-04 | Pfizer Limited | Pharmaceutical complex |
US6350735B1 (en) | 1999-10-14 | 2002-02-26 | Pfizer Inc | Purine derivatives |
US6420557B1 (en) | 2000-07-28 | 2002-07-16 | Pfizer Inc. | Crystalline therapeutic agent |
US6448236B1 (en) | 1999-10-14 | 2002-09-10 | Pfizer Inc | Purine derivatives |
US6468989B1 (en) | 2000-07-13 | 2002-10-22 | Dow Pharmaceutical Sciences | Gel compositions containing metronidazole |
US6548508B2 (en) | 2000-10-20 | 2003-04-15 | Pfizer, Inc. | Use of PDE V inhibitors for improved fecundity in mammals |
US6624158B2 (en) | 2000-09-15 | 2003-09-23 | Pfizer Inc | Purine derivatives |
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AU646020B2 (en) | 1994-02-03 |
RU2099354C1 (en) | 1997-12-20 |
EP0512050A1 (en) | 1992-11-11 |
AU7236491A (en) | 1991-08-21 |
CA2074186C (en) | 2001-04-03 |
JP2722277B2 (en) | 1998-03-04 |
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EP0512050A4 (en) | 1993-04-21 |
KR0166088B1 (en) | 1999-01-15 |
DE69130165D1 (en) | 1998-10-15 |
US5134127A (en) | 1992-07-28 |
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CA2074186A1 (en) | 1991-07-24 |
ATE170742T1 (en) | 1998-09-15 |
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