WO1990013283A1 - Aqueous based personal washing cleanser - Google Patents

Aqueous based personal washing cleanser Download PDF

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Publication number
WO1990013283A1
WO1990013283A1 PCT/GB1990/000700 GB9000700W WO9013283A1 WO 1990013283 A1 WO1990013283 A1 WO 1990013283A1 GB 9000700 W GB9000700 W GB 9000700W WO 9013283 A1 WO9013283 A1 WO 9013283A1
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WO
WIPO (PCT)
Prior art keywords
composition according
active surfactant
acid
composition
acyl
Prior art date
Application number
PCT/GB1990/000700
Other languages
French (fr)
Inventor
Alan Paul Green
Barbara Mcfarquhar
Rosa Paredes
Marianne Mellett
Frederick Silvio Osmer
Original Assignee
Unilever Plc
Unilever Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23366097&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1990013283(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Unilever Plc, Unilever Nv filed Critical Unilever Plc
Priority to DE69010907T priority Critical patent/DE69010907T2/en
Priority to BR909007347A priority patent/BR9007347A/en
Priority to EP90907305A priority patent/EP0479795B1/en
Publication of WO1990013283A1 publication Critical patent/WO1990013283A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/596—Mixtures of surface active compounds

Definitions

  • the present invention is in the field of aqueous based, surfactant containing, mild cleansers, providing good foaming, moisturizing and cleaning, without excessive harshness.
  • moisturizers in traditional washing bars is severely limited by processing constraints. Usually bars with a high content of moisturizer are sticky and cannot be easily stamped. Some of the difficulties of formulating a good personal washing product with high levels of moisturizers were eliminated by using liquid products to avoid the stamping problem.
  • Moisturizers have also been found to inhibit lathering. However, lathering is desirable for washing products. Further, a high concentration of moisturizers while being desirable for mildness and skin benefit has a tendency to de-stabilize liquid products.
  • Japanese Patent JP-A-63/243,200 discloses a detergent composition containing a combination of specified acyl isethionates, higher fatty acids and N-acylglutamic acid salts.
  • US 4 556 510 and 4 617 148 both disclose liquid soaps containing polymeric thickeners along with several other surfactants including optionally sodium cocoyl isethionate.
  • US 4 495 079 discloses a therapeutic facial skin cleanser composed of selected surfactant mixtures and active ingredients.
  • a liquid aqueous based skin cleansing composition characterised in that it comprises (i) at least 3 t% acyl esters of isethionic acid salts, ssaaiidd eesstteerrss bbeing predominantly C O 0 to C_ ⁇ *_ acyl isethionates;
  • weight ratio of said acyl esters to said fatty acid ranges from about 1:0.1 to about 1:10, and soap is present in an amount from 0 to 5% by weight of the composition.
  • aqueous based composition containing acylisethionates, fatty acid, and moisturizer component in specified amounts and ratios can provide a fluid aqueous based cleansing and moisturizing product characterized by its mildness, good lathering properties, acceptable viscosity and stability while substantially eliminating many of the problems of the art.
  • a co-active surfactant is additionally present in an amount at least 2wt% with respect to the total composition.
  • the inventive composition can have the advantages of mildness, good moisturizing, good lathering, and excellent long term stability.
  • Other standard ingredients such as polymeric thickeners, preservatives, further co-surfactants, sequestrants, foam boosters, and the like may also be employed to advantage.
  • composition comprises
  • composition comprises at least 5wt% of said at least one long chain fatty acid, at least 5wt% of said co-active surfactant and at least 5wt% of said moisturizer component.
  • the formulation may suitably contain the following general ingredients provided an appropriate viscosity is achieved:
  • a critical component of the formulations of the present invention is a non-soap anionic surface active agent.
  • Particularly suitable agents for the present invention are the C -C_ 2 acyl isethionates. These esters may be prepared by the reaction between alkali metal isethionate and mixed aliphatic fatty acids having from 8 to 22 carbon atoms and an Iodine Value of less than 20. In one embodiment of the invention at least 75% of these mixed fatty acids should preferably have from 12 to 18 carbon atoms and up to 25% should have from 8 to 10 carbon atoms.
  • alkyl glycerol ether sulfonate Another suitable syndet is that of alkyl glycerol ether sulfonate.
  • Alkyl chains for this surfactant are from C to C ?? , preferably C 1Q to C lg . It is envisaged that the present compositions could be prepared containing alkyl glycerol ether sulfonate in place of or as well as the acyl isethionate.
  • a number of anionic, nonionic, cationic and amphoteric surfactants may be employed as the co-active.
  • co-active combinations in bars with acyl isethionates are disclosed.
  • suitable anionic co-actives are the alkyl sulfates, alkyl ether sulfates, alkyl ether sulfonates, sarcoscommunes, sulfosuccinates, taurates and combinations thereof.
  • suitable amphoteric co-actives may be included alkylbetaines, amidopropyl betaines, amidopropyl sultaines and combinations thereof.
  • the relative amounts of isethionate esters to co-actives will preferably range in the weight ratio of about 20:1 to about 1:1, preferably from about 5:1 to about 2:1, optimally about 3:1.
  • Alkyl ether sulfates will be of the general formula R-0(CH 2 CH 2 ) n 0S0 3 -M + wherein R ranges from C 8 -C 20 alkyl, preferably 12 -C. 5 alkyl, n is an integer from 9 to 40, preferably from 10 to 20, optimally about 12, and M is a sodium, potassium, ammonium or triethanolammonium cation.
  • R ranges from C 8 -C 20 alkyl, preferably 12 -C. 5 alkyl
  • n is an integer from 9 to 40, preferably from 10 to 20, optimally about 12
  • M is a sodium, potassium, ammonium or triethanolammonium cation.
  • Typical commercial co-actives of this variety are listed in the Table below:
  • Alkyl ether sulfonates may also be employed in the present composition.
  • Illustrative of this category is a commercial product known as Avenel S-150 commonly known as a sodium c 12 ⁇ c i 5 Pareth-15 sulfonate.
  • Another co-active type suitable for use in the present composition is that of the sulfosuccinates. This category is best represented by the monoalkyl sulfosuccinates having the formula:
  • Typical commercial products representative of these co-actives are those listed in the Table below:
  • Emcol 4400-1 Disodium Lauryl Solid Witco Sulfosuccinate
  • Sarcosinates may also be useful in the present composition as a co-active. This category is indicated by the general formula RCON(CH 3 )CH-CO_-M , wherein R ranges from C -C 2 alkyl, preferably 12 ⁇ C 1 5 alkvl and M is a sodium, potassium, ammonium or triethanolammonium cation. Typical commercial products representative of these co-actives are those listed in the Table below: Trademark Chemical Name Physical Manu ⁇ Form facturer
  • Taurates may also be employed in the present composition as co-actives. These materials are generally identified by the formula RCONR CH 2 CH 2 S0 -M , wherein R ranges from C 8 -C alkyl, preferably c -C 5 alkyl, R ranges from C -C alkyl, and M is a sodium, potassium, ammonium or triethanolammonium cation. Typical commercial products representative of these co-actives are those listed in the Table below:
  • amphoterics there are three general categories suitable for use in the present compositions. These include alkylbetaines of the formula RN (CH 3 ) 2 CH 2 CO -M , amidopropylbetaines of the formula RCONHCH 2 CH 2 CH 2 N + (CH 3 ) 2 CH 2 CO -M + , and amidopropyl sultaines of the formula RCONHCH 2 CH 2 N (CH 3 ) 2 CH 2 S0 3 ⁇ M + , wherein R ranges from C 8 -C 20 alkyl, preferably C 12 -C 5 alkyl, and M + is a sodium, potassium, ammonium or triethanolammonium cation. Typical commercial products representative of these co-actives are found in the Table below:
  • liquid co-actives Within the broad category of liquid co-actives, the most effective are the alkyl sulfates, alkyl ether sulfates, alkyl ether sulfonates and sulfosuccinates.
  • Free fatty acids of 8-22 carbons are desirably incorporated within the compositions of the present invention. These fatty acids are present to operate as lather enhancing agents and as skin feel, lubricity, and creaminess enhancers.
  • the agents may be selected from fatty acids of carbon atoms numbering 8-18 in an amount up to about 15% by weight erf the composition.
  • the most important agent is a stearic acid/palmitic acid mixture. Levels of these acids can range from 1% up to 15% by weight so as to provide a major proportion of C_, g and above.
  • a combination of principally palmitic and stearic acids of about 45wt% stearic and 55wt% palmitic is preferred.
  • Moisturizers are included to provide skin conditioning benefits and to improve the mildness of the product.
  • the selection of the levels and types of moisturizers to be incorporated into the product is done in such a manner as not to affect adversely the stability of the product or its in-use characteristics, and still deliver good moisturization and lather.
  • moistureturizer is often use synonymously with the term emollient, and is then meant to describe a material which imparts a smooth and soft feeling to the skin surface.
  • One way of reducing water loss from the stratum corneum is to deposit on the surface of the skin a layer which reduces the rate of evaporation.
  • Another method is to add hygroscopic substances, which will retain water, to the stratum corneum, to make this water available to the stratum corneum.
  • moisturizers Both types of moisturizers as well as mixtures of these are operative in the present invention.
  • Some examples of moisturizers are long chain fatty acids, liquid water-soluble polyols, glycerin, propylene glycol, sorbitol, polyethylene glycol, ethoxylated/propoxylated ethers of methyl glucose and ethoxylated/propoxylated ethers of lanolin alcohol.
  • the present composition requires the presence of long chain fatty acids and in addition another moisturizer.
  • the moisturizers useful in the present invention are preferably used at a level of in total about 5% to 35% by weight of the composition.
  • the preferred and more preferred levels of total moisturizers are, respectively, 5wt% to 30wt% and 8wt% to 20wt%.
  • the most preferred moisturizer combination is a mixture of propylene glycol and a combination of stearic and palmitic acids having a weight ratio of glycol to acid of 1:3 to 5:1.
  • the moisturizer combination at the above levels, provides superior moisturization.
  • the high level of moisturizer can provide enhanced mildness.
  • the moisturizer to soap weight ratios when soap is used are preferably 7 to 1 and, more preferably, 4 to 1.
  • moisturizers are compounds found naturally in the stratum corneum of the skin.
  • Moisturizers also include petrolatum, mineral oil, beeswax, silicones, lanolin and oil-soluble lanolin derivatives, saturated and unsaturated fatty alcohols and various animal and vegetable oils.
  • Soaps may optionally be included in the compositions of the present invention as a structurant.
  • Soaps can be used at levels of preferably about 5% and most preferably at a level of about 2% by weight.
  • the soaps may be added neat " or made in situ via adding a base, e-g», NaOH to convert free fatty acids.
  • Other ingredients e-g » NaOH to convert free fatty acids.
  • Free sodium isethionate in an amount of about 1% to about 7% by weight affects stability and viscosity and may also affect mildness and can suitably be included in the present composition. It can either be added as a separate ingredient or may be present in commercially available acyl isethionate.
  • Standard additives such as colouring agents, opacifying agents e.g. TiO_, thickenrs e.g. carbopols may be used with the present compositions in varying amounts to insure appropriate benefits.
  • Sequestering agents such as EDTA, ethylene diamine tetraacetic acid trisodium salt of EHDP [disodium (1-Hydroxyethylidene) biphosphate] or mixtures of these in amounts ranging from 0.01 to as high as 1.0wt% preferably about 0.01 to 0.05wt% may be used.
  • Preservatives such as antimicrobials or antimould/fungus agents may be used. Examples of these are methyl paraben (p hydroxymethylbenzoate) ; propyl paraben (p hydroxypropylbenzoate) ; and Dowicil 200 [N-(3-chlorallyl) Hexaminium chloride]. These and other similar materials may be used in amounts of about 0.lwt% to about 0.5wt% and may be used separately or in combination.
  • Antioxidants such as, for example, butylated hydroxytoluene (BHT) may be used advantageously in amounts of about 0.01wt% or higher if appropriate.
  • BHT butylated hydroxytoluene
  • Viscosity of the formulation is measured with a Brookfield cone and plate H.B.D.V. II viscometer at 2 min. , 25°C and a shear rate of Is .
  • the viscosity of the present compositions can vary from about 100 cps to about 30,000 cps or higher if desirable, and will preferably be from about 10,000 cps to 15,000 cps.
  • Lather evaluations are done by applying a two gram sample to the hands, followed by applying six millilitres of water. The hands are then placed palm to palm and rotated five times in a circular motion in order to dissolve the product. The product is then "worked up” by rotating the hands ten times. The resulting lather is measured by immersing the hands in a distilled water bath and lowering a funnel, whose neck has been fitted with a graduated cylinder, over the hands, so that the volume of lather can be measured.
  • Selected combinations of acyl isethionate and stearic/palmitic acid can show, improved lathering.
  • An aqueous based formulation embodying the present invention contains the following ingredients in the indicated amounts: Ingredients wt%
  • a batch of the present formulation is prepared as follows. Some of the numbers are approximate since commercial solutions vary in content.
  • a submix is first prepared by charging 1451.1kg (3,200 lbs.) of propylene glycol to a tank with agitation. 916 kg (2,019.20 lbs.) of sodium isethionate is added with slow speed agitation. 532.5kg (1,174.40 lbs.) of a slurry containing 293kg (645.9 lbs.) of sodium alkyl benzene sulfonate is then added and mixing is continued to ensure uniformity. 1814.5kg (4,000 lbs.) of a 40% solution of triethanolamine lauryl sulfate is then added and mixed until uniform at a temperature of about 26.6°C to 32.2°C (80 to 90°F) . This submix is then set aside for future use.
  • This material contains 55wt% sodium cocoyl isethionate; 30wt% long chain fatty acids; 8wt% sodium isethionate and 7wt% miscellaneous; 348.5kg (768 lbs.) of soap; 29kg (64 lbs.) of methyl paraben, 14.5 kg (32 lbs.) of propyl paraben, 7.5 kg (16.32 lbs.) of EDTA and 5 kg (10.56 lbs.) of EHDP are added with mixing at about 5 minute intervals. 273 kg (601.60 lbs.) of stearic acid is then added and agitation is increased as necessary to achieve uniformity.
  • the entire batch is then mixed at 79.4°C to 82.2°C (175° to 180° F) to ensure uniformity.
  • the batch is then slowly cooled to about 46.1°C (115°F) .
  • 14.5 kg (32 pounds) of Dowicil is mixed into 18 kg (65 lbs.) of cold deionized water and this mixture is added to the batch.
  • a previously prepared homogeneous fragrance mix composed of 58 kg (128 lbs.) of perfume and 1 kg (2.56 lbs) of BHT are added and mixed into the batch.
  • the entire batch is then mixed and cooled to reach a suitable viscosity.
  • Thickener slurries may, of course, optionally be used at appropriate points. These slurries may contain suitable materials such as polymers, e.g. carbopol, gums and the like.
  • This Example illustrates the equivalency in mildness between a composition A embodying the present invention and a 50% aqueous slurry of a commercial non soap detergent bar B. The percentages of B are approximate. Table I lists the two compositions.
  • Mean end point scores are the mean of the evaluation scores at which the first arm received a grade "2" or greater erythema score or at the completion of nineteen washes.
  • the Flex Wash Test The Flex Wash procedure consists of four daily 60 second washes of the antecubital fossa (flex area of elbow) . This method was designed to produce erythema quickly. Erythemal response varies only slightly with temperature and humidity fluctuations making the protocol suitable for year round testing.
  • Panelist flex areas must be free of any skin condition (eczema, dryness, irritation, cuts or abrasions) .
  • Skin condition eczema, dryness, irritation, cuts or abrasions
  • An antihistamines, anti-inflammatory drugs or topical, oral or injectable cortisone on a regular basis was excluded from the study. The panel was divided into two subgroups which were balanced for left handedness. Group I was assigned composition "A" for the left flex and "B" for the right flex. Group II reversed the order.
  • the panelist was instructed to moisten the left flex area.
  • a sponge was dampened with tap water (100 ppm calcium/magnesium ions) .
  • a fixed amount of test product was applied to the sponge.
  • the "dosed" sponge was placed in the panelist's right hand.
  • the panelist then washed the left flex area for exactly 60 seconds (approximately 120 strokes) .
  • the flex was rinsed and patted dry. This washing procedure was repeated on the right arm with the appropriate composition. Washing by this procedure was repeated 4 times daily for four days and 3 times on the fifth day for a total of 19 washes. Treatment times were scheduled 1.5 hours apart.
  • Each test site was evaluated immediately prior to washing and 4 hours after the third daily wash.
  • the final grading is the sum total of grade scores for 20 assessments per panelist averages over the scores from ail panelists.
  • the average score could range from 0 to 38; the lower value indicating absolutely no skin irritation with the latter being severe. In practice, scores generally range from 15 to 30.
  • the objective is to compare the levels of irritation and/or dryness of two products on skin by assessing the changes in skin condition during exaggerated use conditions. Changes are assessed both visually and instrumentally.
  • the subject/panelist is in the age group of 18-55 years.
  • the subject must have been screened for soap sensitivity and found to be sensitive to the screening solution.
  • the target site must be free of cuts and abrasions and have a grade "0" for both erythema and dryness following a two week preconditioning period.
  • the subject must refrain from using creams, lotions or other types of moisturizing products over the target body area (the forearms) throughout the duration of the test.
  • Subjects are required to precondition their skin using the conditioning product supplied under normal use conditions. This preconditioning period is two weeks in length immediately prior to the onset of the study. Use of the preconditioning product will continue throughout the study for all bathing and showering.
  • a group panel of 30 subjects is randomly selected based on an acceptable skin condition score for dryness and erythema established at baseline.
  • the panel is randomly balanced for age and sex and each panelist is assigned a subject number.
  • Laboratory wash treatments are for two morning sessions and two afternoon sessions over a four day test period. The fifth day includes two morning washes.
  • the time interval between treatment and final assessment are standard within the panel.
  • Visual and tactile assessments are conducted immediately before each wash treatment to evaluate and compare changes in skin condition. A final visual assessment is conducted.
  • the target site is the volar surface of the forearm from the antecubital fossa (flex area) to the wrist.
  • Subjects are supplied with blinded product for all home bathing and are instructed to avoid washing the test site during the test week.
  • each forearm is wet thoroughly from the flex area to the wrist.
  • the product is placed on a wet pad and spread over the pad.
  • the treated pad is then placed on the designated arm and is then gently glided up and down the volar surface of the forearm for two minutes.
  • the arm is rinsed under running water for 30 seconds and patted dry gently with a soft disposable towel.
  • a trained skin evaluator conducts all visual assessments. The forearms are assessed for erythema and dryness immediately prior to each wash treatment. A five point scoring scale (0-4) is used to assess skin condition for both dryness and erythema. Half point increments are used to denote slight differences between arms or for responses not warranting a full point increase.
  • Forearms are treated until a grade "3" or greater erythema or dryness develops (end point score) . Once an end point score is attained treatment of both sites is discontinued. The final visual assessment is conducted approximately three hours after the last wash.
  • Formulation B represents a 50% slurry of a commercial bar. The percentages are thus approximate.
  • Formulation C has no guar gum or viscasil. The test was run to compare the mildness/irritation potential of cleanser C with a 50% slurry of a commercial bar B. The test site was treated with one gram of slurry B or 0.5 gram of the facial cleanser C. Table IV
  • Mean end point scores are the mean of the evaluation scores at which the first arm receives a grade "2" or greater erythema score or grade "3" dryness score or at the completion of nineteen washes.
  • the inventive composition has been evaluated in clinical studies against a slurry of a commercial bar.
  • the scores for the present composition were identical to the slurry scores for erythema.
  • the present composition scores for dryness were very close to those of the slurry. There were some negative differences between the present composition score and the slurry for erythema in the Arm Wash.
  • the test group includes 35 subjects/panelists in the age group of 18 to 55 years.
  • the subject must have no history of allergies or skin diseases. Panelists must refrain from using facial creams, lotions or other type of moisturizing products on their faces throughout the duration of the test period.
  • each subject is provided with (2) bars of commercial soap to be used at home for a two week period prior to the start of testing.
  • Eligible panelists are assigned test products selected at random to equal a Right/Left or Left/Right balance in product assignment to each half-face side.
  • the schedule of wash treatments includes a single facial wash conducted both in the morning and afternoon and for four consecutive test days or a total of 7 wash treatments. Panelists are instructed not to use anything on their faces except to wash with warm water and face cloth.
  • Panelist self-assessment of facial skin condition is conducted once during the study.
  • Panelists will assess their facial condition based on a global evaluation of appearance and feel of skin, comparing both left and right sides of the face.
  • Trained assessors also assess the skin condition using a grade score scale ranging from 0 to 2.5; independent parameters of evaluation will include softness and feel, degree of dryness, erythema and roughness or the face.
  • the raw data scores are analysed employing a paired t-test and parametric statistical design.
  • a half face test was conducted as described above on 35 panelists with "normal" skin types to compare the formulation of the invention and a commercial liquid soap. After one week screening period, the test period consisted of 8 wash treatments over a 4 day span with 9 evaluations done. The first evaluation was made prior to the first wash treatment and the ninth evaluation was made on the morning of the fifth day. The panelists have refrained from the use of anything but water on their faces during the study. Evaluations of various attributes were made by one expert judge and each panelist over the test period.
  • Table VI The top line results of this study are summarized in Table VI.
  • the table indicate those evaluations for which statistically significant differences (with 95% confidence) were detected for each of the expert judge and panelist questions.
  • composition A specified in Table I was compared to a commercial liquid soap with the following results.
  • composition A Liguid Composition A Liguid
  • the judge's scores reflect mean ranks for all panelists.
  • the panelist's scores are individual scores based on a 0-9 scale.
  • Composition A is significantly (95% confidence level) preferred by both judges and panelists for overall softness.
  • the judges also rated the Composition A significantly (95% confidence level) better than the Commercial Liquid for dryness, roughness, tightness, burning, itching and stinging.

Abstract

An aqueous based personal washing product is disclosed which when used has good cleaning ability and is particularly mild to the skin. The free flowing liquid product is particularly adapted for facial washing and contains acyl ester of isethionic acid salt, long fatty acids and moisturizer component, and preferably a co-active surfactant.

Description

AQUEOUS BASED PERSONAL WASHING CLEANSER
Technical Field
The present invention is in the field of aqueous based, surfactant containing, mild cleansers, providing good foaming, moisturizing and cleaning, without excessive harshness.
The use of moisturizers in traditional washing bars is severely limited by processing constraints. Usually bars with a high content of moisturizer are sticky and cannot be easily stamped. Some of the difficulties of formulating a good personal washing product with high levels of moisturizers were eliminated by using liquid products to avoid the stamping problem.
Moisturizers have also been found to inhibit lathering. However, lathering is desirable for washing products. Further, a high concentration of moisturizers while being desirable for mildness and skin benefit has a tendency to de-stabilize liquid products.
It was thus desirable to formulate an aqueous based product containing high levels of moisturizers in combination with high levels of mild surfactants to result in a substantially stable personal washing product which is exceptionally mild to the skin; and having excellent lathering characteristics which also leaves the skin feeling smooth, silky, and moisturized.
Background
Japanese Patent JP-A-63/243,200 discloses a detergent composition containing a combination of specified acyl isethionates, higher fatty acids and N-acylglutamic acid salts. US 4 556 510 and 4 617 148 both disclose liquid soaps containing polymeric thickeners along with several other surfactants including optionally sodium cocoyl isethionate. US 4 495 079 discloses a therapeutic facial skin cleanser composed of selected surfactant mixtures and active ingredients.
There have been many different approaches to the problem of producing an aqueous based mild cleanser containing high levels of emollients/moisturizers together with combinations of mild surfactants having good viscosity, good stability, and high lathering characteristics. None of these approaches has been completely satisfactory. In many cases, stability is sacrificed to improve viscosity, or mildness is de-emphasized to improve cleaning ability or moisturizing is minimized to improve lathering.
Disclosure of the Invention
According to the present invention there is provided a liquid aqueous based skin cleansing composition characterised in that it comprises (i) at least 3 t% acyl esters of isethionic acid salts, ssaaiidd eesstteerrss bbeing predominantly C O0 to C_ώ*_ acyl isethionates;
(ii) at least 2wt% of at least one long chain fatty acid having a major proportion of C_β or above; and
(iii)at least 2wt% of a moisturizer component;
wherein the weight ratio of said acyl esters to said fatty acid ranges from about 1:0.1 to about 1:10, and soap is present in an amount from 0 to 5% by weight of the composition.
The presently defined aqueous based composition containing acylisethionates, fatty acid, and moisturizer component in specified amounts and ratios can provide a fluid aqueous based cleansing and moisturizing product characterized by its mildness, good lathering properties, acceptable viscosity and stability while substantially eliminating many of the problems of the art. Preferably a co-active surfactant is additionally present in an amount at least 2wt% with respect to the total composition.
The inventive composition can have the advantages of mildness, good moisturizing, good lathering, and excellent long term stability. Other standard ingredients such as polymeric thickeners, preservatives, further co-surfactants, sequestrants, foam boosters, and the like may also be employed to advantage.
Preferably the composition comprises
(i) 3 to 20wt% said acyl esters of isethionic acid; (ii) 2 to 15 wt% said long chain fatty acid(s) ;
(iii)2 to 20wt% said co-active surfactant;
(iv) 2 to 15% said moisturizer component.
Suitably the composition comprises at least 5wt% of said at least one long chain fatty acid, at least 5wt% of said co-active surfactant and at least 5wt% of said moisturizer component.
The formulation may suitably contain the following general ingredients provided an appropriate viscosity is achieved:
Ingredients wt%
acylisethionate 3-20% fatty acids 2-15% moisturizer 2-15%' co-surfactant 2-20% preservative 0.1-1% sequestrant 0.01-0.1% standard additives 3-15% water balance
100
Acylisethionate
A critical component of the formulations of the present invention is a non-soap anionic surface active agent. Particularly suitable agents for the present invention are the C -C_2 acyl isethionates. These esters may be prepared by the reaction between alkali metal isethionate and mixed aliphatic fatty acids having from 8 to 22 carbon atoms and an Iodine Value of less than 20. In one embodiment of the invention at least 75% of these mixed fatty acids should preferably have from 12 to 18 carbon atoms and up to 25% should have from 8 to 10 carbon atoms.
Another suitable syndet is that of alkyl glycerol ether sulfonate. Alkyl chains for this surfactant are from C to C??, preferably C1Q to Clg. It is envisaged that the present compositions could be prepared containing alkyl glycerol ether sulfonate in place of or as well as the acyl isethionate.
Co-active surfactant
A number of anionic, nonionic, cationic and amphoteric surfactants may be employed as the co-active. In copending case US Serial Number 340,185 filed on April 19, 1989, co-active combinations in bars with acyl isethionates are disclosed. Among suitable anionic co-actives are the alkyl sulfates, alkyl ether sulfates, alkyl ether sulfonates, sarcosincates, sulfosuccinates, taurates and combinations thereof. Among suitable amphoteric co-actives may be included alkylbetaines, amidopropyl betaines, amidopropyl sultaines and combinations thereof.
The relative amounts of isethionate esters to co-actives will preferably range in the weight ratio of about 20:1 to about 1:1, preferably from about 5:1 to about 2:1, optimally about 3:1.
Alkyl ether sulfates will be of the general formula R-0(CH2CH2)n0S03-M+ wherein R ranges from C8-C20 alkyl, preferably 12-C.5 alkyl, n is an integer from 9 to 40, preferably from 10 to 20, optimally about 12, and M is a sodium, potassium, ammonium or triethanolammonium cation. Typical commercial co-actives of this variety are listed in the Table below:
Trademark Chemical Name Physical Manu¬ Form facturer
Alkasurf ES-60 Sodium Laureth Paste Alkaril
Sulfate
Cycloryl TD TEA Laureth Paste Cyclo
Sulfate
Standapol Sodium Laureth-12 Liquid Henkel 125-E Sulfate
Cedepal Sodium Trideceth Paste Miranol TD407MF Sulfate
Standapol T TEA Lauryl Sulfate Liquid Henkel
Alkyl ether sulfonates may also be employed in the present composition. Illustrative of this category is a commercial product known as Avenel S-150 commonly known as a sodium c 12~c i5 Pareth-15 sulfonate.
Another co-active type suitable for use in the present composition is that of the sulfosuccinates. This category is best represented by the monoalkyl sulfosuccinates having the formula:
R02CCH2CH(S03-Na+)COO-M+; and amido-MEA sulfosuccinates of the formula: RCONHCH2CH2-02CCH2CH(S03-M+)CCO-M+; wherein R ranges from C8-C20 alkyl, preferably c 12-c 15 alkyl and M+ is a sodium, potassium, ammonium or triethanolammonium cation. Typical commercial products representative of these co-actives are those listed in the Table below:
Trademark Chemical Name Physical Manu¬ Form facturer
Emcol 4400-1 Disodium Lauryl Solid Witco Sulfosuccinate
Schercopol Disodium Cocoamido Liquid Scher CMSNa MEA Sulfosuccinate
Emcol 4100M Disodium Paste Witco Myristamido MEA Sulfosuccinate
Schercopol Disodium Oleamido Liquid Scher MEA
Varsulf S13333 Disodium Solid Scherex
Ricinoleamido MEA Sulfosuccinate
Sarcosinates may also be useful in the present composition as a co-active. This category is indicated by the general formula RCON(CH3)CH-CO_-M , wherein R ranges from C -C2 alkyl, preferably 12~C 15 alkvl and M is a sodium, potassium, ammonium or triethanolammonium cation. Typical commercial products representative of these co-actives are those listed in the Table below: Trademark Chemical Name Physical Manu¬ Form facturer
Hamposyl L-95 Sodium Lauroyl Solid W.R.
Sarcosinate Grace
Hamposyl TEA Cocoyl Liquid W.R. TOC-30 Sarcosinate Grace
Taurates may also be employed in the present composition as co-actives. These materials are generally identified by the formula RCONR CH2CH2S0 -M , wherein R ranges from C 8-C alkyl, preferably c -C 5 alkyl, R ranges from C -C alkyl, and M is a sodium, potassium, ammonium or triethanolammonium cation. Typical commercial products representative of these co-actives are those listed in the Table below:
Trademark Chemical Name Physical Manu¬ Form facturer
Igepon TC 42 Sodium Methyl Paste GAF Cocoyl Taurate
Igepon T-77 Sodium Methyl Paste GAF Oleoyl Taurate
Within the category of amphoterics there are three general categories suitable for use in the present compositions. These include alkylbetaines of the formula RN (CH3)2CH2CO -M , amidopropylbetaines of the formula RCONHCH2CH2CH2N+(CH3)2CH2CO -M+, and amidopropyl sultaines of the formula RCONHCH2CH2N (CH3)2CH2S03~M+, wherein R ranges from C8-C20 alkyl, preferably C12-C 5 alkyl, and M+ is a sodium, potassium, ammonium or triethanolammonium cation. Typical commercial products representative of these co-actives are found in the Table below:
Trademark Chemical Name Physical Manu¬ Form facturer
Lonzaine C Cocamidopropyl Liquid Lonza Betaine
Lonzaine CS Cocamidopropyl Liquid Lonza
Hydroxysultaine
Lonzaine 12C Coco-Betaine Liquid Lonza
Schercotaine Myristamidopropyl Liquid Lonza
MAB Betaine
Velvetex Oleyl Betaine Paste Henkel OLB-50
Within the broad category of liquid co-actives, the most effective are the alkyl sulfates, alkyl ether sulfates, alkyl ether sulfonates and sulfosuccinates.
Long chain fatty acids
Free fatty acids of 8-22 carbons are desirably incorporated within the compositions of the present invention. These fatty acids are present to operate as lather enhancing agents and as skin feel, lubricity, and creaminess enhancers. The agents may be selected from fatty acids of carbon atoms numbering 8-18 in an amount up to about 15% by weight erf the composition. The most important agent is a stearic acid/palmitic acid mixture. Levels of these acids can range from 1% up to 15% by weight so as to provide a major proportion of C_,g and above. A combination of principally palmitic and stearic acids of about 45wt% stearic and 55wt% palmitic is preferred.
Moisturizer component
Moisturizers are included to provide skin conditioning benefits and to improve the mildness of the product. The selection of the levels and types of moisturizers to be incorporated into the product is done in such a manner as not to affect adversely the stability of the product or its in-use characteristics, and still deliver good moisturization and lather.
The term "moisturizer" is often use synonymously with the term emollient, and is then meant to describe a material which imparts a smooth and soft feeling to the skin surface.
One way of reducing water loss from the stratum corneum is to deposit on the surface of the skin a layer which reduces the rate of evaporation. Another method is to add hygroscopic substances, which will retain water, to the stratum corneum, to make this water available to the stratum corneum.
Both types of moisturizers as well as mixtures of these are operative in the present invention. Some examples of moisturizers are long chain fatty acids, liquid water-soluble polyols, glycerin, propylene glycol, sorbitol, polyethylene glycol, ethoxylated/propoxylated ethers of methyl glucose and ethoxylated/propoxylated ethers of lanolin alcohol. Thus the present composition requires the presence of long chain fatty acids and in addition another moisturizer.
The moisturizers useful in the present invention, including the long chain free fatty acids, are preferably used at a level of in total about 5% to 35% by weight of the composition. The preferred and more preferred levels of total moisturizers are, respectively, 5wt% to 30wt% and 8wt% to 20wt%. The most preferred moisturizer combination is a mixture of propylene glycol and a combination of stearic and palmitic acids having a weight ratio of glycol to acid of 1:3 to 5:1. The moisturizer combination, at the above levels, provides superior moisturization. The high level of moisturizer can provide enhanced mildness.
The moisturizer to soap weight ratios when soap is used are preferably 7 to 1 and, more preferably, 4 to 1.
Other moisturizers are compounds found naturally in the stratum corneum of the skin.
Moisturizers also include petrolatum, mineral oil, beeswax, silicones, lanolin and oil-soluble lanolin derivatives, saturated and unsaturated fatty alcohols and various animal and vegetable oils.
Soaps
Soaps may optionally be included in the compositions of the present invention as a structurant.
Soaps can be used at levels of preferably about 5% and most preferably at a level of about 2% by weight. The soaps may be added neat"or made in situ via adding a base, e-g», NaOH to convert free fatty acids. Other ingredients
Free sodium isethionate in an amount of about 1% to about 7% by weight affects stability and viscosity and may also affect mildness and can suitably be included in the present composition. It can either be added as a separate ingredient or may be present in commercially available acyl isethionate.
Standard additives such as colouring agents, opacifying agents e.g. TiO_, thickenrs e.g. carbopols may be used with the present compositions in varying amounts to insure appropriate benefits.
Sequestering agents such as EDTA, ethylene diamine tetraacetic acid trisodium salt of EHDP [disodium (1-Hydroxyethylidene) biphosphate] or mixtures of these in amounts ranging from 0.01 to as high as 1.0wt% preferably about 0.01 to 0.05wt% may be used.
Preservatives such as antimicrobials or antimould/fungus agents may be used. Examples of these are methyl paraben (p hydroxymethylbenzoate) ; propyl paraben (p hydroxypropylbenzoate) ; and Dowicil 200 [N-(3-chlorallyl) Hexaminium chloride]. These and other similar materials may be used in amounts of about 0.lwt% to about 0.5wt% and may be used separately or in combination.
Antioxidants such as, for example, butylated hydroxytoluene (BHT) may be used advantageously in amounts of about 0.01wt% or higher if appropriate.
Viscosity Viscosity of the formulation is measured with a Brookfield cone and plate H.B.D.V. II viscometer at 2 min. , 25°C and a shear rate of Is . The viscosity of the present compositions can vary from about 100 cps to about 30,000 cps or higher if desirable, and will preferably be from about 10,000 cps to 15,000 cps.
Lather
Lather evaluations are done by applying a two gram sample to the hands, followed by applying six millilitres of water. The hands are then placed palm to palm and rotated five times in a circular motion in order to dissolve the product. The product is then "worked up" by rotating the hands ten times. The resulting lather is measured by immersing the hands in a distilled water bath and lowering a funnel, whose neck has been fitted with a graduated cylinder, over the hands, so that the volume of lather can be measured.
Selected combinations of acyl isethionate and stearic/palmitic acid can show, improved lathering.
Embodiments of the Invention
The invention will now be illustrated with reference to the following Examples, which are by way of example only. Unless otherwise indicated all percentages are by weight.
Example I
An aqueous based formulation embodying the present invention contains the following ingredients in the indicated amounts: Ingredients wt%
Sodium cocoyl isethionate 11%
Stearic acid 8%
Propylene glycol 10%
Sodium isethionate 5%
TEA lauryl sulfate 5%
Sodium soap * (82/18) 2.5%
Sodium alkylbenzene sulfonate 2%
Fragrance 0.4%
Methylparaben 0.20%
Propylparaben 0.10%
Dowicil 200 0.10%
EDTA 0.02%
EHDP 0.02%
BHT 0.008
Water to 100.00%
* A mixture of 82wt% tallow soap and 18wt% coconut soap.
Process
A batch of the present formulation is prepared as follows. Some of the numbers are approximate since commercial solutions vary in content.
A submix is first prepared by charging 1451.1kg (3,200 lbs.) of propylene glycol to a tank with agitation. 916 kg (2,019.20 lbs.) of sodium isethionate is added with slow speed agitation. 532.5kg (1,174.40 lbs.) of a slurry containing 293kg (645.9 lbs.) of sodium alkyl benzene sulfonate is then added and mixing is continued to ensure uniformity. 1814.5kg (4,000 lbs.) of a 40% solution of triethanolamine lauryl sulfate is then added and mixed until uniform at a temperature of about 26.6°C to 32.2°C (80 to 90°F) . This submix is then set aside for future use.
6159 kg (13,577.76 lbs.) of deionized water is heated and charged to the main mixing tank and is maintained at about 82.2°C (180 degrees F) . The previously prepared submix is then slowly added with slow speed agitation. 2871 kg (6,329.6 lbs.) of a commercial preparation of sodium cocoyl isethionate is then added. This material contains 55wt% sodium cocoyl isethionate; 30wt% long chain fatty acids; 8wt% sodium isethionate and 7wt% miscellaneous; 348.5kg (768 lbs.) of soap; 29kg (64 lbs.) of methyl paraben, 14.5 kg (32 lbs.) of propyl paraben, 7.5 kg (16.32 lbs.) of EDTA and 5 kg (10.56 lbs.) of EHDP are added with mixing at about 5 minute intervals. 273 kg (601.60 lbs.) of stearic acid is then added and agitation is increased as necessary to achieve uniformity. The entire batch is then mixed at 79.4°C to 82.2°C (175° to 180° F) to ensure uniformity. The batch is then slowly cooled to about 46.1°C (115°F) . 14.5 kg (32 pounds) of Dowicil is mixed into 18 kg (65 lbs.) of cold deionized water and this mixture is added to the batch. A previously prepared homogeneous fragrance mix composed of 58 kg (128 lbs.) of perfume and 1 kg (2.56 lbs) of BHT are added and mixed into the batch. The entire batch is then mixed and cooled to reach a suitable viscosity.
Thickener slurries may, of course, optionally be used at appropriate points. These slurries may contain suitable materials such as polymers, e.g. carbopol, gums and the like. EXAMPLE 2
This Example illustrates the equivalency in mildness between a composition A embodying the present invention and a 50% aqueous slurry of a commercial non soap detergent bar B. The percentages of B are approximate. Table I lists the two compositions.
TABLE I
Formulations
A %wt/wt. B %wt. /wt.
Sodium Cocoyl Isethionate 10.95 25.0
Stearic Acid * 8.01 10.0
Na Soap (82/18 tallow/ 2.40 5.5 coconut)
Sodium Alkylbenzenesulfonate 2.02 1.0
Sodium Isethionate 5.09 2.4
TEA Lauryl Sulfate 5.00
Propylene Glycol 10.00 —
Cosmedia Guar C-261 . 0.50 —
(guar gum/thickener)
Methylparaben 0.20 —
Propylparaben 0.10
Dowicil 200 0.10
Viscasil 60M (silicone) 1.00
Perfume 0.10 0.5
Lower Fatty acid — 1.5 Miscellaneous solids 1.7 & electrolytes
Water to 100.00 to 100.00
* Cχ4 = 3%; C16 - 50%; C18 - 47%
Both formulations were tested by Flex Wash. Table II lists the Flex Wash outcome which confirms the equivalent mild behaviour of Formulation A to a 50% slurry of a commercial bar whose major ingredient is sodium cocoyl isethionate.
TABLE II
Flex Wash Test
Sample Mean Scores * Mean Rank
Erythema Endpoint Erythema
A 1.385 13.62 B 1.385 13.38
Statistical Analysis
Rank Score: P = 0.9580
(Wilcoxon 2 sample)
* Mean end point scores are the mean of the evaluation scores at which the first arm received a grade "2" or greater erythema score or at the completion of nineteen washes.
The Flex Wash Test The Flex Wash procedure consists of four daily 60 second washes of the antecubital fossa (flex area of elbow) . This method was designed to produce erythema quickly. Erythemal response varies only slightly with temperature and humidity fluctuations making the protocol suitable for year round testing.
Approximately 15 panelists were used as the test population. Panelist flex areas must be free of any skin condition (eczema, dryness, irritation, cuts or abrasions) . Anyone taking antihistamines, anti-inflammatory drugs or topical, oral or injectable cortisone on a regular basis was excluded from the study. The panel was divided into two subgroups which were balanced for left handedness. Group I was assigned composition "A" for the left flex and "B" for the right flex. Group II reversed the order.
Following an evaluation, the panelist was instructed to moisten the left flex area. A sponge was dampened with tap water (100 ppm calcium/magnesium ions) . A fixed amount of test product was applied to the sponge. The "dosed" sponge was placed in the panelist's right hand. The panelist then washed the left flex area for exactly 60 seconds (approximately 120 strokes) . Thereupon, the flex was rinsed and patted dry. This washing procedure was repeated on the right arm with the appropriate composition. Washing by this procedure was repeated 4 times daily for four days and 3 times on the fifth day for a total of 19 washes. Treatment times were scheduled 1.5 hours apart. Each test site was evaluated immediately prior to washing and 4 hours after the third daily wash.
One trained assessor evaluated test sites prior to each wash and 4 hours after the third wash of the fifth day for a total of 20 evaluations. The grading scale was as follows:
0 - no erythema
0.5 - barely perceptible erythema
1 - mild spotty erythema/no oedema
1.5 - mild/moderate erythema/with or without oedema
2 - moderate confluent erythema/with or without oedema or vesiculation
Each site was treated in the prescribed method until a grading of "2" or greater was attained or 19 washings had been completed. When a score of "2" or greater was attained the treatment was discontinued on that flex. The inal score was then carried through for all remaining evaluations. The remaining flex was washed until either a grading of at least "2" or 19 treatments were attained, whichever was first. In this Example, the final grading is the sum total of grade scores for 20 assessments per panelist averages over the scores from ail panelists. Thus, theoretically the average score could range from 0 to 38; the lower value indicating absolutely no skin irritation with the latter being severe. In practice, scores generally range from 15 to 30.
Arm Wash
The objective is to compare the levels of irritation and/or dryness of two products on skin by assessing the changes in skin condition during exaggerated use conditions. Changes are assessed both visually and instrumentally.
The subject/panelist is in the age group of 18-55 years. The subject must have been screened for soap sensitivity and found to be sensitive to the screening solution. The target site must be free of cuts and abrasions and have a grade "0" for both erythema and dryness following a two week preconditioning period.
The subject must refrain from using creams, lotions or other types of moisturizing products over the target body area (the forearms) throughout the duration of the test.
Subjects with allergies to soap and fragrances, a history of skin disease or currently undergoing treatment for a dermatologic condition or who did not respond positively to the soap sensitivity screening test as well as subjects currently within the 2 weeks prior to the start date, taking antiinflammatory agents are excluded.
Experimental Design
Subjects are required to precondition their skin using the conditioning product supplied under normal use conditions. This preconditioning period is two weeks in length immediately prior to the onset of the study. Use of the preconditioning product will continue throughout the study for all bathing and showering.
A group panel of 30 subjects is randomly selected based on an acceptable skin condition score for dryness and erythema established at baseline. The panel is randomly balanced for age and sex and each panelist is assigned a subject number. Laboratory wash treatments are for two morning sessions and two afternoon sessions over a four day test period. The fifth day includes two morning washes. The time interval between treatment and final assessment are standard within the panel. Visual and tactile assessments are conducted immediately before each wash treatment to evaluate and compare changes in skin condition. A final visual assessment is conducted.
The target site is the volar surface of the forearm from the antecubital fossa (flex area) to the wrist.
Subjects are supplied with blinded product for all home bathing and are instructed to avoid washing the test site during the test week.
Wash Procedure
All wash treatments are conducted by a technician. Both forearms are washed simultaneously taking care to exert equal pressure/force to each arm. Technicians alternate their treatment groups at each wash interval.
1. Using water maintained at 32°C (90°F) each forearm is wet thoroughly from the flex area to the wrist.
2. The product is placed on a wet pad and spread over the pad. The treated pad is then placed on the designated arm and is then gently glided up and down the volar surface of the forearm for two minutes.
3. The arm is rinsed under running water for 30 seconds and patted dry gently with a soft disposable towel.
Visual Assessment
A trained skin evaluator conducts all visual assessments. The forearms are assessed for erythema and dryness immediately prior to each wash treatment. A five point scoring scale (0-4) is used to assess skin condition for both dryness and erythema. Half point increments are used to denote slight differences between arms or for responses not warranting a full point increase.
Dryness Erythema
0 - None 0 - None
1 - Slight flaking 1 - Mild erythema
2 - Moderate flaking/scaling 2 - Moderate confluent erythema
3 - Marked scaling, slight 3 - Marked erythema fissuring
4 - Severe scaling, fissuring 4 - Deep erythema
Forearms are treated until a grade "3" or greater erythema or dryness develops (end point score) . Once an end point score is attained treatment of both sites is discontinued. The final visual assessment is conducted approximately three hours after the last wash.
The arm wash test described above was run comparing the following two products. Formulation C embodies the present invention, whilst Formulation B is a comparative product.
Table III
Ingredients Form. C Comparative Form. B
% t/wt
Sodium Cocoyl Isethionate 10.95 25
Stearic Acid 8.01 10
Sodium Soap 2.40 5.5
Sodium Alkylbenzenesulfonate 2.02 1.0
Sodium Isethionate 5.09 2.4
TEA Lauryl Sulfate 5.00 —
Propylene Glycol 10.00 —
Methylparaben 0.20 —
Propylparaben 0.10 —
Dowicil 200 0.10 —
Fragrance 0.10 0.5
Lower Fatty acid 1.5
Miscellaneous solids 1.5
& electrolytes
Water to 100.00 to 100.00
As in Table I, Formulation B represents a 50% slurry of a commercial bar. The percentages are thus approximate. Formulation C has no guar gum or viscasil. The test was run to compare the mildness/irritation potential of cleanser C with a 50% slurry of a commercial bar B. The test site was treated with one gram of slurry B or 0.5 gram of the facial cleanser C. Table IV
RESULTS OF ARM WASH TEST:
MEAN SCORES * END POINT END POINT
ERYTHEMA DRYNESS
Slurry B 1.000 1.531
Product C 1.250 1.563
MEAN RANK: ERYTHEMA DRYNESS
Slurry B 13.88 15.81
Product C 19.13 17.19
STATISTICAL ANALYSIS OF RANK SCORES: p=0.0981 p=0.6844
(Wilcoxon 2 sample)
* Mean end point scores are the mean of the evaluation scores at which the first arm receives a grade "2" or greater erythema score or grade "3" dryness score or at the completion of nineteen washes.
The results indicated no significant difference (P 0.05) between Product B slurry and Product C based on the mean rank erythema and dryness scores at end point. Product C was somewhat more irritating than the slurry.
SUMMARY
The inventive composition has been evaluated in clinical studies against a slurry of a commercial bar. In the Flex Wash against the slurry, the scores for the present composition were identical to the slurry scores for erythema. In the Arm Wash test, the present composition scores for dryness were very close to those of the slurry. There were some negative differences between the present composition score and the slurry for erythema in the Arm Wash.
Table V
Slurry Present Composition
Flex Wash Erythema 1.385 1.385
Arm Wash Dryness 1.531 1.563
Arm Wash Erythema 1.000 1.250
Facial Wash Study
The test group includes 35 subjects/panelists in the age group of 18 to 55 years. The subject must have no history of allergies or skin diseases. Panelists must refrain from using facial creams, lotions or other type of moisturizing products on their faces throughout the duration of the test period. Upon admittance to the study, each subject is provided with (2) bars of commercial soap to be used at home for a two week period prior to the start of testing.
Eligible panelists are assigned test products selected at random to equal a Right/Left or Left/Right balance in product assignment to each half-face side.
Assigned Groups Include:
Group I Right half, Code B Group II Right half, Code A Left half, Code A Left half, Code B
Procedure
The schedule of wash treatments includes a single facial wash conducted both in the morning and afternoon and for four consecutive test days or a total of 7 wash treatments. Panelists are instructed not to use anything on their faces except to wash with warm water and face cloth.
Each subject has their face washed in the following manner by a technician:
a) Wet both sides of the face 10 seconds
b) An abundant lather is worked up for each test product for 10 seconds by gently rubbing a moistened pad 35 to 37.7°C (95 to 100°F) made of soft non-woven cotton cloth in each product.
c) The lathered pads are then massaged slowly but firmly over the cheek area using a counter-circular motion with a pad in each hand, washing for 60 seconds then rinsing with running water 35 to 37.7°C (95 to 100°F) for 10 seconds. This procedure is repeated a second time to equal a two-minute wash treatment. The face is then rinsed for 60 seconds with warm water and patted dry using soft disposable terry towels.
Evaluation and Scoring System
a) Panelist self-assessment of facial skin condition is conducted once during the study. b) Panelists will assess their facial condition based on a global evaluation of appearance and feel of skin, comparing both left and right sides of the face.
c) Trained assessors also assess the skin condition using a grade score scale ranging from 0 to 2.5; independent parameters of evaluation will include softness and feel, degree of dryness, erythema and roughness or the face.
d) Panelists and trained assessors assess both sides of their face and the same hand at all times. The inside forearm of the opposite arm will represent a reference control site for softness.
Data and Statistics
The raw data scores are analysed employing a paired t-test and parametric statistical design.
A half face test was conducted as described above on 35 panelists with "normal" skin types to compare the formulation of the invention and a commercial liquid soap. After one week screening period, the test period consisted of 8 wash treatments over a 4 day span with 9 evaluations done. The first evaluation was made prior to the first wash treatment and the ninth evaluation was made on the morning of the fifth day. The panelists have refrained from the use of anything but water on their faces during the study. Evaluations of various attributes were made by one expert judge and each panelist over the test period.
The top line results of this study are summarized in Table VI. The table indicate those evaluations for which statistically significant differences (with 95% confidence) were detected for each of the expert judge and panelist questions.
The composition A specified in Table I was compared to a commercial liquid soap with the following results.
Figure imgf000032_0001
TABLE VI
Results of Facial Wash
Attribute Judges * Commercial Panelists * Commercial
Composition A Liguid Composition A Liguid
Overall Softness 24 ** 1 17** 4
Erythema 26.1** 40.9
Dryness 23.4** 43.6 3.6** 5.1
Roughness 22.7** 44.3 3.4** 4.9
Tightness 3.0** 4.1
Burning 2.1** 3.3
Stinging 2.2** 2.9
Itching 2.9** 3.6
* The judge's scores reflect mean ranks for all panelists. The panelist's scores are individual scores based on a 0-9 scale.
** Significant at the 95% confidence level.
In the Half Face test against the Commercial Liquid, Composition A is significantly (95% confidence level) preferred by both judges and panelists for overall softness. The judges also rated the Composition A significantly (95% confidence level) better than the Commercial Liquid for dryness, roughness, tightness, burning, itching and stinging.

Claims

Claims
1. A liquid aqueous based skin cleansing composition characterised in that it comprises:
(i) at least 3wt% acyl esters of isethionic acid salts, said esters being predominantly c -C_2 acyl isethionates;
(ii) at least 2wt% of at least one long chain fatty acid having a major proportion of C_6 or above; and
(iii)at least 2wt% of a moisturizer component;
wherein the weight ratio of said acyl esters to fatty acid ranges from about 1:0.1 to about 1:10, and soap is present in an amount from 0 to 5% by weight of the composition..
2. Composition according to claim 1 comprising additionally at least 2wt% of co-active surfactant.
3. Composition according to claim 2 comprising
(i) 3 to 20 wt% said acyl esters of isethionic acid;
(ϋ) 2 to 15wt% said long chain fatty acid(s) ;
(iii)2 to 20wt% said co-active surfactant;
(iv) 2 to 15wt% said moisturizer component.
4. Composition according to claim 2 or claim 3 comprising at least 5wt% of said at least one long chain fatty acid, at least 5wt% of said co-active surfactant and at least 5wt% of said moisturizer component.
5. Composition according to claim 1 wherein the acyl esters of isethionic acid comprise at least 75% C_2 to C _ acyl isethionates.
6. Composition according to claim 1 wherein the said long chain fatty acids comprises a combination of about 45wt% stearic acid and 55wt% palmitic acid.
7. Composition according to claim 2 wherein the co-active surfactant is one or more components selected from the group comprising anionic, nonionic, cationic and amphoteric surfactants.
8. Composition according to claim 7 wherein the co-active surfactant includes an anionic surfactant and is selected from the group comprising alkyl sulfates, alkyl ether sulfates, alkyl ether sulfonates, sarcosinates, sulfosuccinates, taurates and combinations thereof.
9. Composition according to claim 7 wherein the co-active surfactant includes an amphoteric surfactant and is selected from the group comprising alkylbetaines, amidopropyl betaines, amidopropoyl sultaines and combinations thereof.
10. Composition according to claim 2 wherein the weight ratio of the said acyl esters of isethionic acid to the said co-active surfactant lies in the range of from about 20:1 to about 1:1.
11. Composition according to claim 1 wherein the said moisturizer component is selected from the group comprising liquid water-soluble polyols, glycerin, propylene glycol, sorbitol, polyethylene glycol, ethoxylated/propoxylated ethers of methyl glucose and ethoxylated/propoxylated ethers of lanolin alcohol, and mixtures thereof.
12. Composition according to claim 1 comprising 1 to 7wt% sodium isethionate.
13. Composition according to claim 1 having a viscosity aatt aa sshheeaarr _rate of Is of from about lOOcps to about 30,000 cps.
PCT/GB1990/000700 1989-05-05 1990-05-04 Aqueous based personal washing cleanser WO1990013283A1 (en)

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DE69010907T DE69010907T2 (en) 1989-05-05 1990-05-04 WATER-BASED SKIN CLEANSER.
BR909007347A BR9007347A (en) 1989-05-05 1990-05-04 WATER BASED LIQUID SKIN CLEANING COMPOSITION
EP90907305A EP0479795B1 (en) 1989-05-05 1990-05-04 Aqueous based personal washing cleanser

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US07/347,971 US5132037A (en) 1989-05-05 1989-05-05 Aqueous based personal washing cleanser
US347,971 1989-05-05
USNOTFURNISHED 2006-03-02

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Cited By (31)

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EP0485212A1 (en) * 1990-11-07 1992-05-13 Unilever Plc Detergent composition
EP0542526A1 (en) * 1991-11-12 1993-05-19 Unilever Plc Skin cleansing compositions
WO1993015171A1 (en) * 1992-01-27 1993-08-05 Deutsche Ici Gmbh Pearlescent surfactant composition
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US5336497A (en) * 1992-04-13 1994-08-09 Elizabeth Arden Co., Division Of Conopco, Inc. Cosmetic composition
EP0689581A1 (en) * 1993-01-23 1996-01-03 The Procter & Gamble Company Cleansing compositions
EP0689581A4 (en) * 1993-01-23 1996-08-21 Procter & Gamble Cleansing compositions
WO1994026866A1 (en) * 1993-05-19 1994-11-24 Unilever Plc Improvememts relating to soap bars
US5482643A (en) * 1993-05-19 1996-01-09 Lever Brothers Company, Division Of Conopco, Inc. Soap bars made with ternary system of fatty isethionate ester, fatty acid, and water
US5661189A (en) * 1994-07-19 1997-08-26 Lever Brothers Company, Division Of Conopco, Inc. Detergent composition
WO1996029049A1 (en) * 1995-03-20 1996-09-26 Unilever Plc Liquid cleansing formulations
US5929019A (en) * 1997-01-30 1999-07-27 Lever Brothers Company, Division Of Conopco, Inc. Cleansing composition with separately dispensed cleansing base and benefit base wherein benefit base also comprises surfactant
US6255264B1 (en) 1998-12-15 2001-07-03 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Detergent composition containing a benefit agent made up of aggregated particles
US6534456B2 (en) 2000-03-20 2003-03-18 Unilever Home And Personal Care Usa, Division Of Conopco, Inc. Extrudable multiphase composition comprising a lamellar phase and an isotropic phase
US6534457B2 (en) 2000-03-20 2003-03-18 Unilever Home And Personal Care Usa, Division Of Conopco, Inc. Extrudable multiphase composition comprising lamellar phase inducing structurant in each phase
US9675530B2 (en) 2002-09-20 2017-06-13 The Procter & Gamble Company Striped liquid personal cleansing compositions containing a cleansing phase and a seperate benefit phase
US7511003B2 (en) 2002-11-04 2009-03-31 The Procter & Gamble Company Striped liquid personal cleansing compositions containing a cleansing phase and a separate benefit phase with improved stability
US8124573B2 (en) 2002-11-04 2012-02-28 The Procter & Gamble Company Striped liquid personal cleansing compositions containing a cleansing phase and a separate benefit phase with improved stability
US7867962B2 (en) 2003-05-01 2011-01-11 The Procter & Gamble Company Striped liquid personal cleansing article containing a cleansing phase and a separate benefit phase comprising a high internal phase emulsion
US8084408B2 (en) 2003-05-01 2011-12-27 The Procter & Gamble Company Striped liquid personal cleansing compositions containing a cleansing phase and a separate benefit phase comprising a high internal phase emulsion
US9114087B2 (en) 2003-05-01 2015-08-25 The Procter & Gamble Company Process for making visually distinctive multiple liquid phase compositions
US8951947B2 (en) 2003-12-24 2015-02-10 The Procter & Gamble Company Multi-phase personal cleansing compositions comprising a lathering cleansing phase and a non-lathering structured aqueous phase
US8314054B2 (en) 2004-02-27 2012-11-20 The Procter & Gamble Company Mild multi-phased personal care composition
US7666825B2 (en) 2004-10-08 2010-02-23 The Procter & Gamble Company Stable, patterned multi-phased personal care composition
US7527077B2 (en) 2005-02-25 2009-05-05 The Procter & Gamble Company Multi-phase personal care compositions, processes for making and providing, and articles of commerce
US7820609B2 (en) 2005-04-13 2010-10-26 The Procter & Gamble Company Mild, structured, multi-phase personal cleansing compositions comprising density modifiers
US8088721B2 (en) 2005-04-13 2012-01-03 The Procter & Gamble Company Mild, structured, multi-phase personal cleansing compositions comprising density modifiers
US8084407B2 (en) 2005-04-13 2011-12-27 The Procter & Gamble Company Mild, structured, multiphase personal cleansing compositions comprising density modifiers
US9636283B2 (en) 2005-12-15 2017-05-02 The Procter & Gamble Company Non-migrating colorants in multi-phase personal cleansing compositions
US8158566B2 (en) 2007-03-30 2012-04-17 The Procter & Gamble Company Multiphase personal care composition comprising a structuring system that comprises an associative polymer, a low HLB emulsifier and an electrolyte
US8105996B2 (en) 2007-03-30 2012-01-31 The Procter & Gamble Company Multiphase personal care composition comprising a structuring

Also Published As

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CA2015868A1 (en) 1990-11-05
BR9007347A (en) 1992-04-28
JP2514112B2 (en) 1996-07-10
US5132037A (en) 1992-07-21
CA2015868C (en) 1995-07-18
DE69010907T2 (en) 1994-11-24
ES2057564T3 (en) 1994-10-16
EP0479795A1 (en) 1992-04-15
EP0479795B1 (en) 1994-07-20
AU634777B2 (en) 1993-03-04
AU5561790A (en) 1990-11-29
JPH07501785A (en) 1995-02-23
DE69010907D1 (en) 1994-08-25
ZA903408B (en) 1992-01-29

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