WO1990010470A1 - Device in connection with an inhaler - Google Patents
Device in connection with an inhaler Download PDFInfo
- Publication number
- WO1990010470A1 WO1990010470A1 PCT/SE1990/000137 SE9000137W WO9010470A1 WO 1990010470 A1 WO1990010470 A1 WO 1990010470A1 SE 9000137 W SE9000137 W SE 9000137W WO 9010470 A1 WO9010470 A1 WO 9010470A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- inhaler
- inhalation
- detector
- sound
- dosage
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
- A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
- A61J7/0418—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with electronic history memory
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
- A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
- A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3375—Acoustical, e.g. ultrasonic, measuring means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/43—General characteristics of the apparatus making noise when used correctly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/14—Static flow deviators in tubes disturbing laminar flow in tubes, e.g. archimedes screws
Definitions
- the present invention relates to a device in connection with an inhaler intended for measuring and recording of the inhalation course of a patient.
- the device is intended for use in medical treatment, e.g. in clinical tests, where there is a need for recording a course of events afterwards in order to be able to verify if the patient has taken medicine in the prescribed way.
- the device can also be used to detect the level of trouble of the patient between the patient's visits to a doctor.
- MEMS® system One type of control systems for the medication of patients, used today, the so called MEMS® system, comprises different types of ordinary standard medicines containers, which are provided with microprocessors, which record date and moment for each opening and closing of the containers.
- Nebulizer Chronolog® con ⁇ sists of a small portable device, in which is contained a stan ⁇ dard aerosol container.
- a contact device At each release of an aerosol dose, a contact device is actuated, whereby an electronical memory unit stores date and moment for each dosage fed ou .
- the object of the present invention is to solve the above prob ⁇ lems by a device in connection with an inhaler, which can measure and record if and when a satisfactory medication has been performed in a patient.
- a device of the kind discussed in the beginning is according to the invention characterized in that a detector is provided in the inhaler in connection with a passage for the inhalation air ⁇ flow, whereby the detector is arranged to detect the inhalation airflow through the inhaler as well as the accessibility of the medicine at the inhalation, whereby the combination of the de ⁇ tected values determines if and when the inhalation should be recorded in the electronical unit.
- a change of sound or pressure occuring at the feeding of a pow ⁇ der dose, at the release of a pressure aerosol or at the punc- tuation of a powder capsule can be detected by a detector and the generated signal can subsequently be treated and recorded by the components in an electronical unit.
- a characteristic back noice or a pressure drop, which occurs in the inhaler at inhala ⁇ tion can be detected by the detector and can thereafter be trea- ted and recorded by the electronical unit.
- the device according to the invention is also suitable for use in measuring and recording the level of severity of a patient's sickness state in periods between the patient's visits to a doctor.
- the doctor can get a good picture of the development of the patient's desease du- ring the time between the medical examinations.
- the detector can be comprised of a sound detector, e.g. a micro ⁇ phone of the type electret microphone, but also other types of detectors, such as for example a pressure transmitter, are feasible within the scope of the invention.
- Fig. 1 shows an exploded view of a powder inhaler wherein the airflow through the inhaler is marked with arrows.
- Fig. 2 shows a cross-sectional view through a powder inhaler according to Fig. 1 with a device for measuring and recording sound according to the invention.
- Fig. 3a show two alternative block diagrams of comprised and 3b electronical components in Fig. 2,
- Fig. 4 shows a diagram of how the microphone in Fig. 2 cat ⁇ ches outside, disturbing noise.
- Fig. 5 shows a diagram of how the microphone in Fig. 2 cat ⁇ ches inhalation noise through the inhaler
- Fig. 6 shows a diagram of the measuring signal of the inhala ⁇ tion after passage through filter and amplifier.
- Fig. 7 shows a cross sectional view through a dose aerosol with a device according to the invention.
- Fig. 8 shows a cross sectional view through a powder inhaler for gelatine capsules with a device according to the invention.
- Fig. 1 an exploded view of a powder inhaler is shown, which is driven by the patient's own breath.
- the airflow through the inhaler at the inhalation is marked by arrows A.
- Figs. 1 and 2 show the different parts of the powder inhaler.
- a pivotable control unit 1 with double grip rings 2 cooperates with a dosage unit 3, which, when the operating unit 1 is tur ⁇ ned, feeds a powder dose to an inhalation channel 4.
- the active substance is kept in a substance container 5.
- a mouthpiece 6 is provided with an insert with narrow helical deflection devices 7 for decomposition of the substance powder into an inhalatable powder fraction.
- the dosage unit 3 is shaped as a flat, rotat- able disc with groups of dosage holes 8 and the disc is arranged at the bottom of the substance container 5.
- the dosage holes 8 are filled with substance in the position below the substance container 5.
- a number of scrapers 9 are arranged to abut the dosage disc 3, whereby the scrapers remove excess powder substance above the dosage holes 8 at the turning of the dosage disc 3.
- an electronical unit 11 with a battery 12 as the source of voltage is arranged inside the two separable grip rings 2 of the operating unit.
- Two contact surfaces 13 are arranged on the upper and outer side of the upper grip ring 2.
- a protective cover 14 is put over the mouthpiece 6 of the inhaler and down over the air intakes 10, whereby the protective cover 14 with its lower edge abuts the upper side of the upper grip ring 2.
- the lower edge of the protective cover 14 is provi ⁇ ded with a metal contact ring 15.
- the contact ring 15 abuts the two contact surfaces 13 on the grip ring 2 when the protective cover 14 is put on, whereby the two contact surfaces 13 get electrical contact.
- a microphone 16 is arranged in direct connection with an air channel 17 between the air intakes 10 and the dosage disc 3 and the microphone is connected to the elec ⁇ tronical unit 11 inside the operating unit 1.
- the microphone 16 can alternatively be placed in connection with the air channel, but separated from this through a thin diaphragm.
- the electronical unit is explained more in detail with reference to the block diagram in Fig. 3a.
- the microphone 16 detects the sound of the "click", which occurs upon turning forward of a new dose and the sound of the airflow at an inhalation, and trans- fers these signals.
- a band pass filter 18 separates one for the inhalation typical and suitable working frequency (se Fig. 5) .
- An amplifier 19 lifts up the signal level from the microphone 16, which leaves signals of the order of a few millivolts and the signals will here be amplified to about 1 V.
- the signal is rectified and is low pass filtered in a detector- 20 so that the envelope of the signal is obtained.
- the envelope signal is a measure of the momentary air flow.
- a Schmitt trigger 21 quanti- tizes the signal and leaves the values "approved” and “not approved”, respectively.
- the signal of the microphone is here transformed to a binary signal which states if the strength of the inhalation is sufficient.
- the hysteres of the Schmitt trig ⁇ ger makes that small variations in flow will not make the signal flutter between "approved” and “not approved”.
- the Schmitt trigger 21 might be replaced by an ana ⁇ logue-digital-converter (A/D converter) 22, which is shown in Fig. 3b, the function of which is to measure the airflow one or several times during the inhalation.
- A/D converter ana ⁇ logue-digital-converter
- the microphone signal which is generated by the sound of the forward turning, is rectified in a detector 24 so that the abso- lute value of the signal is obtained.
- An amplifier 25 lifts the level of the signal from the microphone 16 to an order of about 1 V.
- This signal passes a puls stretcher 26, which stretches the short, transient "click" sound to a signal with logical levels and a sufficient duration for a processor to record it.
- the processor 27 shall keep track of acual time, i.e. be a clock, collect the treated signals from the micorphone and through these signals check that the patient takes his dosage in the prescribed way.
- the prescribed way means that the patient shall turn forward a dose and breath with a sufficient flow and sufficient duration in order to obtain an effective deposition in the lungs.
- the processor 27 performs the measurement of the length of the inhalation and transfers the time for an approved inhalation to the memory unit 23.
- the processor 27 also detects if the contact surfaces are short circuited, that is if the pro ⁇ tective cover 14 is put on, and takes care of the communication with a reading unit, which reads the gathered information in the memory unit 23.
- the processor 27 supplies the band pass filter
- the memory unit 23 is suitably comprised of an EPROM (Electri ⁇ cally Eraseably Programmable Read Only Memory) , which is an electrically eraseable, fixed memory.
- EPROM Electrically eraseable Read Only Memory
- An EPROM is preferably used here since the information must not be lost if the battery should be finished. In this memory the times of inhalation is saved for approved inhalations and optional inhalation measure ⁇ ment test results.
- Fig. 4 shows a diagram of how disturbing noise from the outside, in this case music from the radio at an extremely high sound le- vel, is captured by the microphone 16 inside the powder inhaler according to Fig.2.
- Fig. 5 shows the corresponding diagram of how the microphone 16 reacts to the airflow through the inhaler at the inhalation.
- the lower graph shows a sound spectrum for an airflow of 10 1/min
- the other graphs, in the upward direction show the corre ⁇ sponding sound spectra for 20 1/min, 30 1/min and 60 1/min, res ⁇ pectively.
- the measuring range which is of interest for the air- flow lies in the range of between 20 1/min and 100 1/min. Since the measurements should be insensitive for outside noise distur ⁇ sayes it is evident from the graphs in Figs. 4 and 5 that a signal at the frequency of 9 kHz is a suitable measuring signal in this embodiment.
- Fig. 6 shows the size of the measuring signal in Volts after filter and amplifier at inhalation flows from 20 1/min to 80 1/mi .
- the noise Since the noise has a characteristic segment, only noise at this frequency is amplified by the ampli ⁇ bomb 19.
- the signal after the amplifier is quantitized in two steps, insufficient flow or sufficient flow. Alternatively the signal can be measured at several levels with optional grading.
- the time for the inha- lation is stored in the memory 23 and in the alternative case also the "value" of the inhalation is stored.
- the doctor can, by sepa ⁇ rating the two grip rings 2, get access to the electronical unit and read the memory 23 using a special reading equipment, which is connected to the electronical unit.
- This reading equipment reads the approved inhalation times and transfers the informa ⁇ tion to a computer, which can process and present the material in a way suitable for the doctor.
- the "value" of the inhalation is also read, which can be presented as a flow/time diagram or as an inhalation measure, e.g. peak inspiratory flow, PIF of to- tal volume (VC) .
- a dose aerosol with pressure filled canister In Fig. 7 is shown a dose aerosol with pressure filled canister.
- the pressure canister 28 is provided with a nozzle 29 and is placed in a bracket 30 with a nozzle 31.
- the bracket 30 is sha- ped with a separable unit, which comprises a detector 32 in connection with the air channel for the inhalation flow and an electronical unit 33.
- the patient shall, during the introductory phase of the inhala ⁇ tion, press the canister 28 down so that a dose is released through the nozzle 29.
- the air flow aorund the canister 28 and the bracket 30 give rise to a noise, which can be detected by a noise detector 32.
- a noise detector 32 When a dosage is released through the nozzle a sound arises, which can be distinguished from the noise and can be detected by the detector. Since these sounds are diffe ⁇ rent from each other, a microphone can be used as detector also in this embodiment.
- a pressure drop is created between the ambient pressure and the pressure at the mouthpiece opening, i.e. a sub-pressure arises inside the bracket 30 when the patient inhales, which sub-pressure can be detected by a pressure transmitter.
- a pressure transmitter At the release of a dose a strong pressure change with short duration arises, which is also detectable by a pressure transmitter.
- a pressure transmitter can be used for detection of both the inhalation and the release of a dose, i.e. the information necessary for controlling that the patient uses the dose aerosol in the prescribed way.
- Fig. 8 shows a powder inhaler, which is loaded with a gelatine capsule 34 with powder substance.
- An electronical unit 35 with detector 36 works in a similar way as the powder inhaler shown in Fig. 2.
- a capsule When a capsule is placed in the inhaler it is punctuated/broken by needles 37 brought through the wall of the capsule.
- the capsule When the capsule has been punc ⁇ tuated/broken the substance will be available for the inhalation flow.
- the punctuation/braking of the capsule causes a short and intensive sound which is detected by the microphone 36.
- inha- lation here also arises a characteristic sound which is detec ⁇ ted/measured in the same way as in the other embodiments.
- the device according to the invention is also suitable for use in an inhalator with rotating parts, e.g. of the type Rotacaps® in that instead of measuring the level of the sound one measures the dominating frequency of the rotation sound.
- the recorded frequency images and can be transformed into a measure of the airflow through the inhaler.
- any type of external computer contact might be arranged in the cover of the inhaler, thereby being accessible for reading without any need of demounting the inhaler.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019900702391A KR0135309B1 (en) | 1989-03-07 | 1990-03-02 | Device in connection with an inhaler |
US08/088,628 US5331953A (en) | 1989-03-07 | 1990-03-02 | Device in connection with an inhaler |
CA 2028830 CA2028830C (en) | 1989-03-07 | 1990-03-02 | Device in connection with an inhaler |
NO904809A NO175289C (en) | 1989-03-07 | 1990-11-05 | Device in connection with an inhaler |
FI905521A FI102948B (en) | 1989-03-07 | 1990-11-07 | Inhaler and method of recording a medication performed by an inhaler |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8900793A SE466684B (en) | 1989-03-07 | 1989-03-07 | DEVICE INHALATOR AND PROCEDURE TO REGISTER WITH THE DEVICE INHALATOR MEDICATION |
SE8900793-4 | 1989-03-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1990010470A1 true WO1990010470A1 (en) | 1990-09-20 |
Family
ID=20375263
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE1990/000137 WO1990010470A1 (en) | 1989-03-07 | 1990-03-02 | Device in connection with an inhaler |
Country Status (16)
Country | Link |
---|---|
US (1) | US5331953A (en) |
EP (1) | EP0387222B1 (en) |
JP (1) | JP2927541B2 (en) |
KR (1) | KR0135309B1 (en) |
AT (1) | ATE91911T1 (en) |
AU (1) | AU613264B2 (en) |
CA (1) | CA2028830C (en) |
DE (1) | DE69002353T2 (en) |
DK (1) | DK0387222T3 (en) |
ES (1) | ES2042267T3 (en) |
FI (1) | FI102948B (en) |
IE (1) | IE64129B1 (en) |
NO (1) | NO175289C (en) |
PT (1) | PT93347B (en) |
SE (1) | SE466684B (en) |
WO (1) | WO1990010470A1 (en) |
Cited By (37)
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EP0617628A1 (en) * | 1991-12-20 | 1994-10-05 | Circadian, Inc. | Intelligent inhaler providing feedback to both patient and medical professional |
US5495848A (en) * | 1994-11-25 | 1996-03-05 | Nellcar Puritan Bennett | Monitoring system for delivery of therapeutic gas |
US5505195A (en) * | 1993-09-16 | 1996-04-09 | Medtrac Technologies Inc. | Dry powder inhalant device with dosage and air flow monitor |
US5544647A (en) * | 1994-11-29 | 1996-08-13 | Iep Group, Inc. | Metered dose inhalator |
US5622163A (en) * | 1994-11-29 | 1997-04-22 | Iep Group, Inc. | Counter for fluid dispensers |
US5890490A (en) * | 1996-11-29 | 1999-04-06 | Aylsworth; Alonzo C. | Therapeutic gas flow monitoring system |
US5911219A (en) * | 1997-04-18 | 1999-06-15 | Aylsworth; Alonzo C. | Therapeutic gas flow meter and monitor |
US5947117A (en) * | 1994-11-15 | 1999-09-07 | Bayer Aktiengesellschaft | Precipitation system for a powder inhaler |
US6076521A (en) * | 1994-11-29 | 2000-06-20 | Astra Aktiebolag | Dose indicating device |
US6240918B1 (en) * | 1996-02-21 | 2001-06-05 | Schering Corporation | Powdered medication inhaler |
US6260549B1 (en) | 1998-06-18 | 2001-07-17 | Clavius Devices, Inc. | Breath-activated metered-dose inhaler |
US7935065B2 (en) | 2005-05-03 | 2011-05-03 | The University Of Western Ontario | Oral device |
US8074594B2 (en) | 2003-12-15 | 2011-12-13 | Trudell Medical International | Dose indicating device |
US8157128B2 (en) | 1998-01-16 | 2012-04-17 | Trudell Medical International | Indicating device |
US8221356B2 (en) | 2004-10-21 | 2012-07-17 | Novo Nordisk A/S | Medication delivery system with a detector for providing a signal indicative of an amount of a set and/or ejected dose of drug |
EP2563436A1 (en) | 2010-04-26 | 2013-03-06 | Sagentia Limited | Drug delivery device |
US8517009B2 (en) | 2008-07-13 | 2013-08-27 | Map Pharmaceuticals, Inc. | Methods and apparatus for delivering aerosolized medication |
US8517729B2 (en) | 2010-03-04 | 2013-08-27 | The University of Western Ontario and Trudell Medical International | Oral mouthpiece and method for the use thereof |
US8540660B2 (en) | 2008-04-15 | 2013-09-24 | University Of Western Ontario | Swallowing air pulse therapy mouthpiece and method for the use thereof |
US8578934B2 (en) | 2003-10-28 | 2013-11-12 | Trudell Medical International | Indicating device with warning dosage indicator |
US8596265B2 (en) | 2008-10-22 | 2013-12-03 | Trudell Medical International | Modular aerosol delivery system |
US8662075B2 (en) | 1998-05-05 | 2014-03-04 | Trudell Medical International | Dispensing device |
US8973784B2 (en) | 2005-01-20 | 2015-03-10 | Trudell Medical International | Dispensing device |
US9101723B2 (en) | 2006-03-20 | 2015-08-11 | Novo Nordisk A/S | Electronic module for mechanical medication delivery devices |
US9265901B2 (en) | 2006-08-01 | 2016-02-23 | Trudell Medical International | Dispensing device |
US9767708B2 (en) | 2012-04-04 | 2017-09-19 | Genia Medical Inc. | Medicament training device and system |
US10004657B2 (en) | 2008-02-08 | 2018-06-26 | The University Of Western Ontario | Method of brain activation |
US10028885B2 (en) | 2013-03-15 | 2018-07-24 | The University Of Western Ontario | Oral mouthpiece and method for the use thereof |
US10283014B2 (en) | 2012-04-04 | 2019-05-07 | Jbcb Holdings, Llc | Smart packaging and display system |
US10383996B2 (en) | 2004-10-21 | 2019-08-20 | Novo Nordisk A/S | Injection device with a processor for collecting ejection information |
US10850050B2 (en) | 2016-05-19 | 2020-12-01 | Trudell Medical International | Smart valved holding chamber |
US10881818B2 (en) | 2016-07-08 | 2021-01-05 | Trudell Medical International | Smart oscillating positive expiratory pressure device |
US10894142B2 (en) | 2016-03-24 | 2021-01-19 | Trudell Medical International | Respiratory care system with electronic indicator |
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US11395890B2 (en) | 2018-06-04 | 2022-07-26 | Trudell Medical International | Smart valved holding chamber |
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US11712175B2 (en) | 2019-08-27 | 2023-08-01 | Trudell Medical International | Smart oscillating positive expiratory pressure device with feedback indicia |
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IT1248059B (en) * | 1991-06-14 | 1995-01-05 | Miat Spa | MULTI-DOSE INSUFFLATOR FOR POWDER DRUGS |
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WO1993024165A1 (en) * | 1992-05-29 | 1993-12-09 | Ggu Gesellschaft Für Gesundheits- Und Umweltforschung Mbh & Co. Vertriebs Kg | Device for generating inhalable active substance particles |
US6509006B1 (en) | 1992-07-08 | 2003-01-21 | Inhale Therapeutic Systems, Inc. | Devices compositions and methods for the pulmonary delivery of aerosolized medicaments |
US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
GB2273660B (en) * | 1992-09-11 | 1996-07-17 | Aid Medic Ltd | Drug delivery arrangement |
RU2111020C1 (en) * | 1992-12-18 | 1998-05-20 | Шеринг Корпорейшн | Powdered drug inhaler |
EP0681491B1 (en) * | 1993-01-29 | 2000-12-13 | Aradigm Corporation | Intrapulmonary delivery of hormones |
US5505192A (en) * | 1993-11-12 | 1996-04-09 | New-Med Corporation | Dispenser monitoring system |
DE4422710C1 (en) * | 1994-06-29 | 1995-09-14 | Boehringer Ingelheim Kg | Inhaler with storage container for aerosol |
US6390088B1 (en) | 1993-12-13 | 2002-05-21 | Boehringer Ingelheim Kg | Aerosol inhaler |
DE4400084C2 (en) * | 1994-01-04 | 2001-08-02 | Softec Gmbh & Co Kg | Device for administering medication in solid form finely distributed in an air stream |
US6051256A (en) * | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
ES2218543T3 (en) | 1994-03-07 | 2004-11-16 | Nektar Therapeutics | PROCEDURE AND PREPARATION FOR THE ADMINISTRATION OF INSULIN BY PULMONARY ROUTE. |
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- 1990-03-02 DE DE1990602353 patent/DE69002353T2/en not_active Expired - Lifetime
- 1990-03-02 EP EP19900850086 patent/EP0387222B1/en not_active Expired - Lifetime
- 1990-03-05 IE IE76590A patent/IE64129B1/en not_active IP Right Cessation
- 1990-03-06 PT PT93347A patent/PT93347B/en not_active IP Right Cessation
- 1990-11-05 NO NO904809A patent/NO175289C/en not_active IP Right Cessation
- 1990-11-07 FI FI905521A patent/FI102948B/en active IP Right Grant
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US5495848A (en) * | 1994-11-25 | 1996-03-05 | Nellcar Puritan Bennett | Monitoring system for delivery of therapeutic gas |
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Also Published As
Publication number | Publication date |
---|---|
FI905521A0 (en) | 1990-11-07 |
EP0387222A1 (en) | 1990-09-12 |
KR0135309B1 (en) | 1998-04-23 |
CA2028830C (en) | 2000-02-08 |
JP2927541B2 (en) | 1999-07-28 |
IE64129B1 (en) | 1995-07-12 |
NO904809D0 (en) | 1990-11-05 |
NO175289B (en) | 1994-06-20 |
AU613264B2 (en) | 1991-07-25 |
EP0387222B1 (en) | 1993-07-28 |
PT93347A (en) | 1990-11-07 |
AU5271090A (en) | 1990-10-09 |
CA2028830A1 (en) | 1990-09-08 |
SE8900793D0 (en) | 1989-03-07 |
NO175289C (en) | 1994-09-28 |
IE900765L (en) | 1990-09-07 |
ES2042267T3 (en) | 1993-12-01 |
NO904809L (en) | 1990-11-05 |
US5331953A (en) | 1994-07-26 |
PT93347B (en) | 1998-05-29 |
FI102948B1 (en) | 1999-03-31 |
FI102948B (en) | 1999-03-31 |
ATE91911T1 (en) | 1993-08-15 |
DE69002353D1 (en) | 1993-09-02 |
SE8900793L (en) | 1990-09-08 |
DK0387222T3 (en) | 1993-08-30 |
KR920700050A (en) | 1992-02-19 |
JPH03504457A (en) | 1991-10-03 |
SE466684B (en) | 1992-03-23 |
DE69002353T2 (en) | 1993-12-02 |
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