WO1990005528A3 - Anti-thrombotic steroids - Google Patents

Anti-thrombotic steroids Download PDF

Info

Publication number
WO1990005528A3
WO1990005528A3 PCT/US1989/004875 US8904875W WO9005528A3 WO 1990005528 A3 WO1990005528 A3 WO 1990005528A3 US 8904875 W US8904875 W US 8904875W WO 9005528 A3 WO9005528 A3 WO 9005528A3
Authority
WO
WIPO (PCT)
Prior art keywords
thrombotic
steroids
potentiators
thrombosis
cyclodextrin
Prior art date
Application number
PCT/US1989/004875
Other languages
French (fr)
Other versions
WO1990005528A2 (en
Inventor
Moses Judah Folkman
Original Assignee
Childrens Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Medical Center filed Critical Childrens Medical Center
Publication of WO1990005528A2 publication Critical patent/WO1990005528A2/en
Publication of WO1990005528A3 publication Critical patent/WO1990005528A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

Anti-thrombotic compositions include anti-thrombotic steroids together with potentiators thereof (e.g. heparin or cyclodextrin) or with a thrombolytic substance such as tissue plasminogen activator. Therapy, in which thrombosis in a mammal at risk is prevented or treated, comprises administering an effective amount of a steroid possessing anti-thrombotic activity or a pharmaceutically acceptable salt thereof.
PCT/US1989/004875 1988-11-01 1989-11-01 Anti-thrombotic steroids WO1990005528A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26559088A 1988-11-01 1988-11-01
US265,590 1988-11-01

Publications (2)

Publication Number Publication Date
WO1990005528A2 WO1990005528A2 (en) 1990-05-31
WO1990005528A3 true WO1990005528A3 (en) 1990-07-12

Family

ID=23011078

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1989/004875 WO1990005528A2 (en) 1988-11-01 1989-11-01 Anti-thrombotic steroids

Country Status (2)

Country Link
JP (1) JPH03502105A (en)
WO (1) WO1990005528A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0114589A1 (en) * 1982-12-20 1984-08-01 The President And Fellows Of Harvard College Inhibition of angiogenesis
US4727064A (en) * 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
US4771042A (en) * 1985-11-25 1988-09-13 The Upjohn Company Inhibition of angiogenesis involving the coadministration of steroids with heparin or heparin fragments

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0114589A1 (en) * 1982-12-20 1984-08-01 The President And Fellows Of Harvard College Inhibition of angiogenesis
US4727064A (en) * 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
US4771042A (en) * 1985-11-25 1988-09-13 The Upjohn Company Inhibition of angiogenesis involving the coadministration of steroids with heparin or heparin fragments

Also Published As

Publication number Publication date
JPH03502105A (en) 1991-05-16
WO1990005528A2 (en) 1990-05-31

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