WO1990001063A1 - New secretory leader sequences - Google Patents
New secretory leader sequences Download PDFInfo
- Publication number
- WO1990001063A1 WO1990001063A1 PCT/GB1989/000816 GB8900816W WO9001063A1 WO 1990001063 A1 WO1990001063 A1 WO 1990001063A1 GB 8900816 W GB8900816 W GB 8900816W WO 9001063 A1 WO9001063 A1 WO 9001063A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ser
- leu
- phe
- sequence
- arg
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Saccharide Compounds (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019900700595A KR100195632B1 (en) | 1988-07-23 | 1989-07-14 | New secretory leader sequences |
EP89909015A EP0387319B1 (en) | 1988-07-23 | 1989-07-14 | Secretory leader sequences |
DE68925893T DE68925893T2 (en) | 1988-07-23 | 1989-07-14 | SECRETORIC LEADER SEQUENCES |
GB8928849A GB2230268B (en) | 1988-07-23 | 1989-12-21 | Leader sequences for the secretion of heterologous polypeptides from fungi. |
FI901428A FI104564B (en) | 1988-07-23 | 1990-03-21 | Peptide and DNA sequences |
DK199000729A DK175853B1 (en) | 1988-07-23 | 1990-03-21 | Secretory leader sequences |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888817598A GB8817598D0 (en) | 1988-07-23 | 1988-07-23 | Dna & peptide sequences |
GB898906920A GB8906920D0 (en) | 1989-03-28 | 1989-03-28 | Peptide and dna sequences |
GB8906920.7 | 1989-03-28 | ||
GB8817598.9 | 1989-03-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1990001063A1 true WO1990001063A1 (en) | 1990-02-08 |
Family
ID=26294196
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1989/000816 WO1990001063A1 (en) | 1988-07-23 | 1989-07-14 | New secretory leader sequences |
Country Status (15)
Country | Link |
---|---|
US (1) | US5302697A (en) |
EP (1) | EP0387319B1 (en) |
JP (1) | JP3092811B2 (en) |
KR (1) | KR100195632B1 (en) |
AT (1) | ATE135045T1 (en) |
AU (1) | AU633020B2 (en) |
CA (1) | CA1340547C (en) |
DE (1) | DE68925893T2 (en) |
DK (1) | DK175853B1 (en) |
FI (1) | FI104564B (en) |
GB (1) | GB2230268B (en) |
HU (1) | HU213571B (en) |
IE (1) | IE62266B1 (en) |
IL (1) | IL91024A (en) |
WO (1) | WO1990001063A1 (en) |
Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0366400A2 (en) * | 1988-10-26 | 1990-05-02 | Tonen Corporation | DNA encoding human serum albumin a (HSA), plasmids and hosts containing such DNA, and the production of HSA |
WO1992011378A1 (en) * | 1990-12-19 | 1992-07-09 | Novo Nordisk A/S | A method of constructing synthetic leader sequences |
US5521086A (en) * | 1993-09-16 | 1996-05-28 | Cephalon, Inc. | Secretion sequence for the production of a heterologous protein in yeast |
US5919654A (en) * | 1995-02-03 | 1999-07-06 | Asahi Glass Company Ltd. | Secretion signal gene and expression vector containing it |
WO2003060071A2 (en) | 2001-12-21 | 2003-07-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
WO2004009819A2 (en) * | 2002-07-23 | 2004-01-29 | Delta Biotechnology Limited | Polypeptides with a signal sequence comprising an fivsi motif and olynucleotides encoding therefor |
US6867231B1 (en) | 1997-06-14 | 2005-03-15 | Enzacta R & D Limited | Therapeutic systems |
US7045318B2 (en) * | 1995-12-30 | 2006-05-16 | Delta Biotechnology Limited | Recombinant fusion proteins to growth hormone and serum albumin |
WO2006067511A1 (en) | 2004-12-23 | 2006-06-29 | Novozymes Delta Limited | Gene expression technique |
WO2009019314A1 (en) | 2007-08-08 | 2009-02-12 | Novozymes A/S | Transferrin variants and conjugates |
EP2048234A1 (en) | 1999-01-30 | 2009-04-15 | Novozymes Biopharma UK Limited | Chromatographic method for purification of albumin |
EP2048236A1 (en) | 2003-12-23 | 2009-04-15 | Novozymes Biopharma DK A/S | Gene expression technique |
EP2090589A1 (en) | 2002-02-07 | 2009-08-19 | Dyax Corp. | Albumin-fused Kunitz domain peptides |
EP2206720A1 (en) | 2000-04-12 | 2010-07-14 | Human Genome Sciences, Inc. | Albumin fusion proteins |
WO2010089385A1 (en) | 2009-02-06 | 2010-08-12 | Novozymes Biopharma Dk A/S | Purification process |
WO2010092135A2 (en) | 2009-02-11 | 2010-08-19 | Novozymes Biopharma Uk Ltd. | Albumin variants and conjugates |
US8252551B2 (en) | 2003-12-23 | 2012-08-28 | Novozymes Biopharma Dk A/S | 2-micron family plasmid and use thereof |
US8420087B2 (en) | 2004-01-05 | 2013-04-16 | Antisoma Research Limited | Interleukin-12 targeted to oncofoetal fibronectin |
WO2014012082A2 (en) | 2012-07-13 | 2014-01-16 | Zymeworks Inc. | Multivalent heteromultimer scaffold design an constructs |
US8765915B2 (en) | 2006-02-06 | 2014-07-01 | Csl Behring Gmbh | Modified coagulation factor VIIa with extended half-life |
WO2014182970A1 (en) | 2013-05-08 | 2014-11-13 | Zymeworks Inc. | Bispecific her2 and her3 antigen binding constructs |
WO2016086320A1 (en) | 2014-12-05 | 2016-06-09 | UNIVERSITé LAVAL | Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases |
US9499605B2 (en) | 2011-03-03 | 2016-11-22 | Zymeworks Inc. | Multivalent heteromultimer scaffold design and constructs |
US9505823B2 (en) | 2006-08-07 | 2016-11-29 | TEV A Biopharmaceuticals USA, Inc. | Albumin-insulin fusion proteins |
WO2017112847A1 (en) | 2015-12-22 | 2017-06-29 | Albumedix A/S | Improved protein expression strains |
WO2018234349A1 (en) | 2017-06-20 | 2018-12-27 | Albumedix Ltd | Improved protein expression strains |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1340772C (en) * | 1987-12-30 | 1999-09-28 | Patricia Tekamp-Olson | Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences |
DK105489D0 (en) * | 1989-03-03 | 1989-03-03 | Novo Nordisk As | POLYPEPTIDE |
US5766883A (en) * | 1989-04-29 | 1998-06-16 | Delta Biotechnology Limited | Polypeptides |
FR2650598B1 (en) * | 1989-08-03 | 1994-06-03 | Rhone Poulenc Sante | DERIVATIVES OF ALBUMIN WITH THERAPEUTIC FUNCTION |
FR2686899B1 (en) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | NOVEL BIOLOGICALLY ACTIVE POLYPEPTIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
US5712114A (en) * | 1995-06-06 | 1998-01-27 | Basf Aktiengesellschaft | Compositions for expression of proteins in host cells using a preprocollagen signal sequence |
ATE406577T1 (en) * | 1997-11-07 | 2008-09-15 | Conjuchem Biotechnologies Inc | METHODS FOR SCREENING AFFINITY MARKER LIBRARIES |
US20050100991A1 (en) * | 2001-04-12 | 2005-05-12 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US6946134B1 (en) | 2000-04-12 | 2005-09-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US20060084794A1 (en) * | 2001-04-12 | 2006-04-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US7507413B2 (en) | 2001-04-12 | 2009-03-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US20050054051A1 (en) * | 2001-04-12 | 2005-03-10 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US20050244931A1 (en) * | 2001-04-12 | 2005-11-03 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US7176278B2 (en) | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
WO2003030821A2 (en) * | 2001-10-05 | 2003-04-17 | Human Genome Sciences, Inc. | Albumin fusion proteins |
EP1463752A4 (en) * | 2001-12-21 | 2005-07-13 | Human Genome Sciences Inc | Albumin fusion proteins |
US20080194481A1 (en) | 2001-12-21 | 2008-08-14 | Human Genome Sciences, Inc. | Albumin Fusion Proteins |
CA2513213C (en) | 2003-01-22 | 2013-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
MXPA06006392A (en) | 2003-12-05 | 2007-03-15 | Childrens Hosp Medical Center | Oligosaccharide compositions and use thereof in the treatment of infection. |
CN101511868B (en) | 2006-07-24 | 2013-03-06 | 比奥雷克西斯制药公司 | Exendin fusion proteins |
WO2008051383A2 (en) * | 2006-10-19 | 2008-05-02 | Amgen Inc. | Use of alcohol co-solvents to improve pegylation reaction yields |
PE20081140A1 (en) * | 2006-10-25 | 2008-09-22 | Amgen Inc | THERAPEUTIC AGENTS BASED ON PEPTIDES DERIVED FROM TOXINS |
MX2009012609A (en) | 2007-05-22 | 2009-12-07 | Amgen Inc | Compositions and methods for producing bioactive fusion proteins. |
WO2010108153A2 (en) | 2009-03-20 | 2010-09-23 | Amgen Inc. | Carrier immunoglobulins and uses thereof |
TW201129379A (en) | 2009-11-20 | 2011-09-01 | Amgen Inc | Anti-Orai1 antigen binding proteins and uses thereof |
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EP2619226B1 (en) | 2010-09-22 | 2018-09-12 | Amgen Inc. | Carrier immunoglobulins and uses thereof |
KR20140009311A (en) | 2011-01-18 | 2014-01-22 | 암젠 인크 | Nav1.7 knockout mice and uses thereof |
CN103930437A (en) | 2011-03-16 | 2014-07-16 | 安姆根有限公司 | Potent and selective inhibitors of Nav1.3 and Nav1.7 |
CA2864702A1 (en) | 2012-02-22 | 2013-08-29 | Amgen Inc. | Autologous mammalian models derived from induced pluripotent stem cells and related methods |
UY35397A (en) | 2013-03-12 | 2014-10-31 | Amgen Inc | POWERFUL AND SELECTIVE INHIBITORS OF NaV1.7 |
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WO2016061141A1 (en) | 2014-10-13 | 2016-04-21 | University Of Maryland, Baltimore | Methods for treating cardiovascular dysfunction and improving fluid homeostasis with a peptide hormone |
MX2017004769A (en) | 2014-10-15 | 2017-10-16 | Amgen Inc | Promoter and regulatory elements for improved expression of heterologous genes in host cells. |
JP6937309B2 (en) | 2016-01-27 | 2021-09-22 | ジャスト−エヴォテック バイオロジックス、インコーポレイテッド | Hybrid promoter and its use |
WO2018094316A1 (en) | 2016-11-21 | 2018-05-24 | Just Biotherapeutics, Inc. | Aflibercept formulations and uses thereof |
DK3668985T3 (en) | 2017-08-17 | 2021-09-20 | Just Evotec Biologics Inc | PROCEDURE FOR PURIFICATION OF GLYCOSYLED PROTEIN FROM HOST CELL GALECTINS AND OTHER IMPURITIES |
WO2019099965A1 (en) | 2017-11-20 | 2019-05-23 | Just Biotherapeutics, Inc. | Aflibercept formulations containing a lysine salt as tonicifying agent and uses thereof |
SG11202107441RA (en) | 2019-02-15 | 2021-08-30 | Just Evotec Biologics Inc | Automated biomanufacturing systems, facilities, and processes |
US11739166B2 (en) | 2020-07-02 | 2023-08-29 | Davol Inc. | Reactive polysaccharide-based hemostatic agent |
WO2023287707A1 (en) | 2021-07-15 | 2023-01-19 | Just-Evotec Biologics, Inc. | Bidirectional tangential flow filtration (tff) perfusion system |
WO2023154305A2 (en) | 2022-02-10 | 2023-08-17 | Amgen Inc. | Antibody protein product expression constructs for high throughput sequencing |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0123544A2 (en) * | 1983-04-25 | 1984-10-31 | Genentech, Inc. | Process for expressing heterologous protein in yeast, expression vehicles and yeast organisms therefor |
EP0127304A1 (en) * | 1983-04-25 | 1984-12-05 | Genentech, Inc. | Process for producing heterologous protein in yeast, expression vehicle therefor, and yeast transformed therewith |
EP0206783A2 (en) * | 1985-06-20 | 1986-12-30 | The Salk Institute Biotechnology Industrial Associates, Inc. | Expression and secretion of polypeptides from saccharomyces cerevisiae |
EP0220689A2 (en) * | 1985-10-25 | 1987-05-06 | Zymogenetics, Inc. | Method of using bar1 for secreting foreign proteins |
EP0252561A2 (en) * | 1986-07-11 | 1988-01-13 | SCLAVO S.p.A. | Expression and secretion vector in yeasts, useful for preparing heterologous proteins |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4588684A (en) * | 1983-04-26 | 1986-05-13 | Chiron Corporation | a-Factor and its processing signals |
FR2593518B1 (en) * | 1985-05-02 | 1989-09-08 | Transgene Sa | VECTORS FOR THE EXPRESSION AND SECRETION OF HIRUDIN BY TRANSFORMED YEASTS |
AU6543286A (en) * | 1985-10-25 | 1987-05-19 | Zymogenetics Inc. | Method of using bar1 for secreting foreign proteins |
GB8613388D0 (en) * | 1986-06-03 | 1986-07-09 | Delta Biotechnology Ltd | Induction of galactose regulated gene expression in yeast |
JP2507874B2 (en) * | 1986-11-27 | 1996-06-19 | 工業技術院長 | DNA sequence encoding a secretory signal peptide |
-
1989
- 1989-07-14 WO PCT/GB1989/000816 patent/WO1990001063A1/en active IP Right Grant
- 1989-07-14 DE DE68925893T patent/DE68925893T2/en not_active Expired - Lifetime
- 1989-07-14 HU HU894572A patent/HU213571B/en unknown
- 1989-07-14 KR KR1019900700595A patent/KR100195632B1/en not_active IP Right Cessation
- 1989-07-14 AT AT89909015T patent/ATE135045T1/en not_active IP Right Cessation
- 1989-07-14 AU AU40427/89A patent/AU633020B2/en not_active Expired
- 1989-07-14 EP EP89909015A patent/EP0387319B1/en not_active Expired - Lifetime
- 1989-07-14 JP JP01508293A patent/JP3092811B2/en not_active Expired - Lifetime
- 1989-07-17 CA CA000605832A patent/CA1340547C/en not_active Expired - Fee Related
- 1989-07-18 IL IL9102489A patent/IL91024A/en unknown
- 1989-07-20 IE IE236189A patent/IE62266B1/en not_active IP Right Cessation
- 1989-12-21 GB GB8928849A patent/GB2230268B/en not_active Expired
-
1990
- 1990-03-21 DK DK199000729A patent/DK175853B1/en not_active IP Right Cessation
- 1990-03-21 FI FI901428A patent/FI104564B/en active IP Right Grant
-
1993
- 1993-05-21 US US08/067,243 patent/US5302697A/en not_active Expired - Lifetime
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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EP0123544A2 (en) * | 1983-04-25 | 1984-10-31 | Genentech, Inc. | Process for expressing heterologous protein in yeast, expression vehicles and yeast organisms therefor |
EP0127304A1 (en) * | 1983-04-25 | 1984-12-05 | Genentech, Inc. | Process for producing heterologous protein in yeast, expression vehicle therefor, and yeast transformed therewith |
EP0206783A2 (en) * | 1985-06-20 | 1986-12-30 | The Salk Institute Biotechnology Industrial Associates, Inc. | Expression and secretion of polypeptides from saccharomyces cerevisiae |
EP0220689A2 (en) * | 1985-10-25 | 1987-05-06 | Zymogenetics, Inc. | Method of using bar1 for secreting foreign proteins |
EP0252561A2 (en) * | 1986-07-11 | 1988-01-13 | SCLAVO S.p.A. | Expression and secretion vector in yeasts, useful for preparing heterologous proteins |
Non-Patent Citations (1)
Title |
---|
DIALOG INFORMATION SERVICES, File 351, World Patent Index 81-89, Dialog Accession No. 88-195319/28, AGENCY OF IND. SCI. TECH., "DNA Sequence Coding Secretory Signal Peptide - Secretes Protein when DNA Sequence is Integrated Between Promoter and Exotix Gene in Yeast Host"; & JP,A,63 133 986, (06-06-88), 8828 (Basic). * |
Cited By (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0366400A3 (en) * | 1988-10-26 | 1990-08-01 | Tonen Corporation | Dna encoding human serum albumin a (hsa), plasmids and hosts containing such dna, and the production of hsa |
US5759802A (en) * | 1988-10-26 | 1998-06-02 | Tonen Corporation | Production of human serum alubumin A |
EP0366400A2 (en) * | 1988-10-26 | 1990-05-02 | Tonen Corporation | DNA encoding human serum albumin a (HSA), plasmids and hosts containing such DNA, and the production of HSA |
WO1992011378A1 (en) * | 1990-12-19 | 1992-07-09 | Novo Nordisk A/S | A method of constructing synthetic leader sequences |
US5521086A (en) * | 1993-09-16 | 1996-05-28 | Cephalon, Inc. | Secretion sequence for the production of a heterologous protein in yeast |
US5919654A (en) * | 1995-02-03 | 1999-07-06 | Asahi Glass Company Ltd. | Secretion signal gene and expression vector containing it |
EP1681304A2 (en) | 1995-12-30 | 2006-07-19 | Delta Biotechnology Limited | Recombinant fusion proteins of growth hormone and serum albumin |
US7045318B2 (en) * | 1995-12-30 | 2006-05-16 | Delta Biotechnology Limited | Recombinant fusion proteins to growth hormone and serum albumin |
US8642542B2 (en) | 1995-12-30 | 2014-02-04 | Novozymes Biopharma Dk A/S | Recombinant fusion proteins to growth hormone and serum albumin |
US6867231B1 (en) | 1997-06-14 | 2005-03-15 | Enzacta R & D Limited | Therapeutic systems |
US7138122B2 (en) | 1997-06-14 | 2006-11-21 | Enzacta R & D Limited | Therapeutic systems |
EP2048234A1 (en) | 1999-01-30 | 2009-04-15 | Novozymes Biopharma UK Limited | Chromatographic method for purification of albumin |
EP2272961A1 (en) | 1999-01-30 | 2011-01-12 | Novozymes Biopharma DK A/S | Process for producing recombinant albumin with reduced mannosylation |
EP2267026A1 (en) | 2000-04-12 | 2010-12-29 | Human Genome Sciences, Inc. | Albumin fusion proteins |
EP2236152A1 (en) | 2000-04-12 | 2010-10-06 | Human Genome Sciences, Inc. | Albumin fusion proteins |
EP2357008A1 (en) | 2000-04-12 | 2011-08-17 | Human Genome Sciences, Inc. | Albumin fusion proteins |
EP2311872A1 (en) | 2000-04-12 | 2011-04-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
EP2298355A2 (en) | 2000-04-12 | 2011-03-23 | Human Genome Sciences, Inc. | Albumin fusion proteins |
EP2295456A1 (en) | 2000-04-12 | 2011-03-16 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US9821039B2 (en) | 2000-04-12 | 2017-11-21 | Albumedix A/S | Albumin fusion proteins |
US9849162B2 (en) | 2000-04-12 | 2017-12-26 | Albumedix A/S | Treatment with factor VII-albumin fusion protein |
EP2206720A1 (en) | 2000-04-12 | 2010-07-14 | Human Genome Sciences, Inc. | Albumin fusion proteins |
EP2213743A1 (en) | 2000-04-12 | 2010-08-04 | Human Genome Sciences, Inc. | Albumin fusion proteins |
EP2216409A1 (en) | 2000-04-12 | 2010-08-11 | Human Genome Sciences, Inc. | Albumin fusion proteins |
EP2275557A1 (en) | 2000-04-12 | 2011-01-19 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US7847079B2 (en) | 2001-12-21 | 2010-12-07 | Human Genome Sciences, Inc. | Albumin fusion proteins |
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US8252739B2 (en) | 2001-12-21 | 2012-08-28 | Human Genome Sciences, Inc. | Albumin fusion proteins |
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Also Published As
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EP0387319B1 (en) | 1996-03-06 |
KR100195632B1 (en) | 1999-06-15 |
US5302697A (en) | 1994-04-12 |
CA1340547C (en) | 1999-05-18 |
KR920700288A (en) | 1992-02-19 |
DE68925893T2 (en) | 1996-08-08 |
DK175853B1 (en) | 2005-04-04 |
HU213571B (en) | 1997-08-28 |
GB2230268B (en) | 1992-01-29 |
AU633020B2 (en) | 1993-01-21 |
EP0387319A1 (en) | 1990-09-19 |
AU4042789A (en) | 1990-02-19 |
GB8928849D0 (en) | 1990-07-18 |
FI104564B (en) | 2000-02-29 |
DE68925893D1 (en) | 1996-04-11 |
HUT57829A (en) | 1991-12-30 |
JPH03500370A (en) | 1991-01-31 |
FI901428A0 (en) | 1990-03-21 |
ATE135045T1 (en) | 1996-03-15 |
HU894572D0 (en) | 1991-05-28 |
DK72990A (en) | 1990-03-21 |
IL91024A0 (en) | 1990-02-09 |
IE892361L (en) | 1990-01-23 |
GB2230268A (en) | 1990-10-17 |
JP3092811B2 (en) | 2000-09-25 |
IE62266B1 (en) | 1995-01-11 |
DK72990D0 (en) | 1990-03-21 |
IL91024A (en) | 1995-08-31 |
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