WO1989011878A2 - A method of removing deposits from objects such as contact lenses - Google Patents
A method of removing deposits from objects such as contact lenses Download PDFInfo
- Publication number
- WO1989011878A2 WO1989011878A2 PCT/GB1989/000559 GB8900559W WO8911878A2 WO 1989011878 A2 WO1989011878 A2 WO 1989011878A2 GB 8900559 W GB8900559 W GB 8900559W WO 8911878 A2 WO8911878 A2 WO 8911878A2
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- WIPO (PCT)
- Prior art keywords
- solution
- contact lenses
- lens
- objects
- cleaning
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
- A61L12/141—Biguanides, e.g. chlorhexidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/10—Halogens or compounds thereof
- A61L12/102—Chlorine dioxide (ClO2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/10—Halogens or compounds thereof
- A61L12/107—Hypohalites; Active halogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/12—Non-macromolecular oxygen-containing compounds, e.g. hydrogen peroxide or ozone
- A61L12/124—Hydrogen peroxide; Peroxy compounds
Definitions
- the present invention provides a safe, convenient and simple method of removing all of these deposits in a matter of seconds.
- a one step method of cleaning and removing harmful deposits from objects such as contact lenses comprises:
- an inhibitor or detoxifyer comprising one or more inhibiting/detoxifying compounds (such as soya bean saponin) in tablet, solution or particle form which react with the protease or other deposit remover in said solution, and thereby form an aqueous solution containing said reaction products with the addition of mild disinfectants, buffers and stabilizers (if these are desired) and having a pH of 6.5 - 8.5, and a coating encasing said tablet or particles which dissolves gradually in said solution so as to release one or more inhibiting/detoxifying compounds and other water soluble agents only after a predetermined period of time has elapsed, preferably about 15 - 20 minutes, whereby said released compounds transform said solution in situ into a buffered lens storage solution. After this the lens should be rinsed briefly before being reinserted into the eye.
- an inhibitor or detoxifyer comprising one or more inhibiting/detoxifying compounds (such as soya bean saponin) in tablet, solution or particle form which react with the protease or other deposit
- the lens should emerge from the solution of said cleaning regimen in a clean, disinfected and deposit free state.
- the inhibitor/detoxifyer is placed into the solution, in which the lens is immersed, at any time before the lens is freed of deposits, but only after the lens has been in the solution long enough to be freed of deposits and deproteinized.
- the lens and inhibitor are placed into the solution at about the same time, and preferably simultaneously with the inhibitor enclosed within a time capsule whose release is predetermined.
- the detoxifyer/inhibitor is provided to transform the solution into a buffered and disinfected solution in which the lens can be safely stored and this transformation takes place after a predetermined period of time.
- the present invention in its preferred embodiment is particularly advantageous because it lets the wearer perform all the necessary steps at one time.
- the lens, inhibitor and deposit remover are sealed into a container the user does not need thereafter to break the sterility.
- the detoxifying agent will stop the activity of the protease or other deposit remover for the user inside a sterilized environment.
- the inhibitor/detoxifying agents can contain water soluble buffering agents and disinfectants to provide that when the inhibitor dissolves and the activity of the deposit remover has been arrested, the resultant solution of buffering agents, reaction products and disinfectants is a stable, buffered solution in which the lens can be safely stored.
- the lens may initially be placed, in a disinfecting solution such as H202 (Hydr ⁇ gen peroxide).
- a disinfecting solution such as H202 (Hydr ⁇ gen peroxide).
- the tablet, particle or other solution inhibitor/detoxifyer should also contain compounds that will effectively neutralize the disinfecting solution (e.g. catalase or sodium pyruvate) as well as compounds that remove the harmful deposits (protease) and also other compounds designed to inactivate the deposit remover (soya bean saponin) after it has had a chance to effectively remove the deposits from a lens.
- Such an embodiment is not as difficult as it sounds to compose so long as all ingredients are held within separate time capsules that are designed to release at predetermined times.
- the inhibitor/detoxifyer may (if desired) contain a small amount of a chelating agent such as EDTA. In certain circumstances this additive may help retain the stability of other agents in the solution and could also help any preservative or disinfectant that may be present to retain its activity.
- the detoxifyer may also include an acid and a base which form an effervescent couple that react in solution to generate a stream of C02 bubbles when the components dissolve.
- the detoxifyer/inhibitor may be a coated tablet wherein the components within said tablet dissolve within a predetermined time span when placed within the subject solution.
- a number of particles can be prepared, each particle once again having the ability to release its contents into the subject solution after a predetermined timespan.
- An alternative embodiment of this invention can be carried out with the aid of a suitable cleaning apparatus comprising tank means that will vibrate or agitate lenses in the tank which contains the appropriate cleaning solution.
- the cleaning compositions to be used with this embodiment of the invention preferably should comprise at least one catalyst of an acid or alkaline nature.
- the catalyst will aid the removal of harmful deposits from the surface of the object to be cleaned.
- the object may then be neutralized by alkali's such as sodium bicarbonate or can simply be rinsed away with saline if the catalyst is alkaline.
- the composition may alternatively comprise a group of powerful detergents or surfactants that are known or proven to be effective at removing strongly adhering deposits from objects such as contact lenses.
- the preferred embodiment will comprise a combination of strong surfactants having dimethyl - polysiloxane - polyoxyalkylene together with the appropriate catalyst as the active ingredient.
- a tablet When using this composition for cleaning contact lenses, a tablet may be formulated comprising a alkaline substance such as sodium bicarbonate and a disinfecting composition such as H202 (Hydrogen peroxide), chlorhexidine or chlorine.
- a disinfecting composition such as H202 (Hydrogen peroxide), chlorhexidine or chlorine.
- H202 Hydrophilicity Agent
- the tablet is dissolved in a measured amount of H20 or saline and then used to neutralize, disinfect and detoxify the lens after cleaning.
- the most preferred embodiment is one that combines the deposit removing compounds together with the detoxifying compounds and also includes disinfecting agents which will formulate a completely all in one contact lens solution.
- Example 1 This composition will not require neutralization
- Part (B) of this composition is a tablet prepared on a hand punch to give a tablet of hardness 2.5kg.
- Chlorine 0.009 When a contact lens containing protein deposits is immersed within said composition of deposit removing compounds and is additionally subjected to the specified ranges of epicyclic movement in a rotational or linear sense, the desired results are actually achieved. Protein film and biofilm layers are quickly and effectively removed and the process will help in the removal of the many other deposits that adhere to an object such as a contact lens. For example the presence of organic protein deposits on a lens may predispose that lens to buildups of inorganic matter such as calcium and the like. By therefore employing this system to protein deposits a great many other deposits may also be reduced and possibly even eliminated.
- the time required to remove these deposits and rinse them thereafter can be reduced to a time of approximately 30 - 60 seconds when operating at a frequency of 30 - 50 Hz, thus allowing such a regimen to be performed daily.
- neutralization of the acid catalyst may be achieved by using simple, universal compounds such as sodium bicarbonate although the use of an alkaline catalyst may be preferred.
- the lens to be cleaned is first removed from the eye and then immersed in a vial containing a compound known to be effective at removing proteinaceous deposits from contact lenses.
- Suitable compounds include the proteolytic enzymes that are non toxic to the eye of the user of the lens.
- Papain is an enzyme derived from the native green fruit of the tropical pawpaw or melon tree Ccarica papaya) whose clear watery fluid is collected, dried and sieved to produce papain.
- Other suitable enzymes include trypsin, ficin, subtilisin A, bromelin and other such enzymes known to be effective at removing deposits from contact lenses. Normally the lens would be soaked in this solution for a period in excess of 15 - 30 minutes.
- the lens and enzyme solution is subjected to epicyclic movement of 30 - 50 Hz and is then exposed to detoxifying compounds which inactivate the enzyme in a process that can be achieved in 30 - 60 seconds.
- the detoxifying compounds may comprise sulfhydryl reagents such as iodocietamide or iodocicetic acids which will react with the free sulfhydryl in the enzyme and lead to inactivation of the papain.
- Soya bean extracts such as soya bean saponin are also known to be inhibitory.
- carbobenzozy-L-glutamic acids or even Chloromethyl ketones of phenylamine and lyslne may help to detoxify the active ingredient.
- Aldehyde reagents such as phenlhyyrazine or hydroykmine will be effective.
- One of the aforementioned compounds can be used in conjunction with Hydrogen peroxide at a concentration of 3%.
- This composition will rapidly inactivate the enzyme and will also serve as an effective disinfectant with excellent antimicrobial properties.
- the detoxifying compounds will act to minimise the accumulation of enzyme that adheres to the lens and H202 (Hydrogen peroxide) will reduce the activity of the enzyme to at least 15% of its original activity within one minute.
- An object such as a contact lens is immersed in a solution comprising disinfectants, deposit removers, detoxifying co pounds and neutralizers which react with each otherto clean, disinfect and remove harmful deposits from the lens in an all in on action.
- the lens is then rinsed briefly before being re-inserted in the eye.
- An object such as a contact lens is immersed in a solution comprising disinfectants, deposit removers, detoxifying co pounds and neutralizers which react with each other to clean, disinfect and remove harmful deposits from the lens in an all in o action.
- the lens is then rinsed briefly before being re-inserted in the eye.
- An object such as a contact lens is immersed in a solution comprising disinfectants, deposit removers, detoxifying co pounds and neutralizers which react with eachotherto clean, disinfect and remove harmful deposits fromthe lens in an all in action.
- the lens is then rinsed briefly before being re-inserted in the eye.
Abstract
An object such as a contact lens is immersed in a solution comprising disinfectants, deposit removers, detoxifying compounds and neutralizers which react with each other to clean, disinfect and remove harmful deposits from the lens in an all in one action. The lens is then rinsed briefly before being re-inserted in the eye.
Description
A method of removing deposits from objects such as contact lenses
Present methods of removing deposits are unsatisfactory, thus in recent years there has been an alarming rise in the numbers of people developing eye infections, corneal ulcers or even going blind as a direct result of wearing contact lenses. The problem is caused because waste matter produced by the eye which the body would normally excrete is deposited on the lens and thus remains in the eye. The stubborn nature of these deposits means that the compositions currently employed in removing them are very toxic and can cause damage to eye tissue if used too frequently or if they are not thoroughly rinsed after cleaning.
The most common type of deposit to be found on the majority of contact lenses are stubborn and tenacious protein deposits. The incidence of protein deposits amongst contact lens wearers ranges from very low to nearly 100 percent but over 8 out of every 10 lenses are likely to show depositions. Glycoproteins, mucoproteins, lysozymes, globulins, mucins, lipids and calciums are just some of the substances that adhere to contact lenses during wear Several different deposit removing compositions are currently needed to cope with all of these different substances. Another potentially dangerous consequence of these deposits, especially the protein deposit, is that a disinfecting solution containing preservatives such as chlorhexidine may chemically bind to the protein on the lens. This may result in both an increased contact time between the preservative and the eye tissue and also an increased concentration of the preservative, which will result in red eye reactions or stinging or burning sensations.
The percentage incidence of these reactions reported in literature seems to vary widely from over 50% to 10% but even the lowest report will be seen to represent a significant proportion of lens wear problems. As o result the contact lens industry has seen a significant shift away from the use
of preservative based disinfecting solutions. The problems caused by protein and other harmful deposits on contact lenses still, however, remains to be solved. It would be desirable to find a contact lens care system that could remove the vast majority of deposits, especially protein deposits that adhere to objects such as contact lenses, preferably on a daily basis.
Contact lens wearers are at present instructed to clean their lenses using a surfactant cleaning solution. However once protein deposits have formed on the lens they cannot be removed by surfactant cleaners alone no matter how thin the film of protein may be. Therefore patients are additionally advised to remove protein deposits from lenses by then soaking the lenses in either a proteolytic enzyme solution or an intensive cleaning solution for a time of between 15 minutes to 12 hours intermitantly or each weekend. Illustrative compounds are described in US patents No.3 910 296 and 4 048 122 respectively. Cleaning lenses intermitantly with such compounds will not protect nor prevent lenses from collecting all the harmful deposits again in a week of normal daily wear. Cleaning lenses in this way is also a time consuming procedure which can sometimes last for many hours and thus is often ignored by the lens wearer altogether. Apart from this e. patient is also expected to remove calcium deposits from his lenses with the aid of a calcium deposit remover which once again requires 15 to 20 minutes to be effective. It would be desirable therefore to find a regimen that could reduce the amount of time it takes to remove stubborn and tenacious deposits from objects such as contact lenses and also be able to remove all harmful deposits in one step.
The present invention provides a safe, convenient and simple method of removing all of these deposits in a matter of seconds. Herewith is an embodiment in which there is provided a one step method of cleaning and removing harmful
deposits from objects such as contact lenses. The process comprises:
1. Immersing the lens in a predetermined volume of an aqueous solution consisting essentially of a protease or other deposit removing compound at a concentration suitable for removing deposits from the lens.
2. Arresting the action of the deposit removing compound in said solution by adding to said solution an inhibitor or detoxifyer comprising one or more inhibiting/detoxifying compounds (such as soya bean saponin) in tablet, solution or particle form which react with the protease or other deposit remover in said solution, and thereby form an aqueous solution containing said reaction products with the addition of mild disinfectants, buffers and stabilizers (if these are desired) and having a pH of 6.5 - 8.5, and a coating encasing said tablet or particles which dissolves gradually in said solution so as to release one or more inhibiting/detoxifying compounds and other water soluble agents only after a predetermined period of time has elapsed, preferably about 15 - 20 minutes, whereby said released compounds transform said solution in situ into a buffered lens storage solution. After this the lens should be rinsed briefly before being reinserted into the eye.
The lens should emerge from the solution of said cleaning regimen in a clean, disinfected and deposit free state. In the broadest aspect of this invention the inhibitor/detoxifyer is placed into the solution, in which the lens is immersed, at any time before the lens is freed of deposits, but only after the lens has been in the solution long enough to be freed of deposits and deproteinized. In the preferred embodiment, the lens and inhibitor are placed into the solution at about the same time, and preferably simultaneously with the inhibitor enclosed within a time capsule whose release is predetermined. Specifically the detoxifyer/inhibitor is provided to transform the solution into a buffered and disinfected solution in which the lens
can be safely stored and this transformation takes place after a predetermined period of time.
The present invention in its preferred embodiment is particularly advantageous because it lets the wearer perform all the necessary steps at one time. In addition, once the lens, inhibitor and deposit remover are sealed into a container the user does not need thereafter to break the sterility. The detoxifying agent will stop the activity of the protease or other deposit remover for the user inside a sterilized environment.
As beforementioned the inhibitor/detoxifying agents can contain water soluble buffering agents and disinfectants to provide that when the inhibitor dissolves and the activity of the deposit remover has been arrested, the resultant solution of buffering agents, reaction products and disinfectants is a stable, buffered solution in which the lens can be safely stored.
Alternatively the lens may initially be placed, in a disinfecting solution such as H202 (Hydrσgen peroxide). In this case the tablet, particle or other solution inhibitor/detoxifyer should also contain compounds that will effectively neutralize the disinfecting solution (e.g. catalase or sodium pyruvate) as well as compounds that remove the harmful deposits (protease) and also other compounds designed to inactivate the deposit remover (soya bean saponin) after it has had a chance to effectively remove the deposits from a lens. Such an embodiment is not as difficult as it sounds to compose so long as all ingredients are held within separate time capsules that are designed to release at predetermined times.
The inhibitor/detoxifyer may (if desired) contain a small amount of a chelating agent such as EDTA. In certain circumstances this additive may help retain the stability of other agents in the solution and could also help any preservative or disinfectant that may be present to retain its activity. The detoxifyer may also include an acid and a
base which form an effervescent couple that react in solution to generate a stream of C02 bubbles when the components dissolve.
The detoxifyer/inhibitor may be a coated tablet wherein the components within said tablet dissolve within a predetermined time span when placed within the subject solution. Alternatively instead of having one tablet, a number of particles can be prepared, each particle once again having the ability to release its contents into the subject solution after a predetermined timespan.
An alternative embodiment of this invention, can be carried out with the aid of a suitable cleaning apparatus comprising tank means that will vibrate or agitate lenses in the tank which contains the appropriate cleaning solution. The cleaning compositions to be used with this embodiment of the invention preferably should comprise at least one catalyst of an acid or alkaline nature. The catalyst will aid the removal of harmful deposits from the surface of the object to be cleaned. The object may then be neutralized by alkali's such as sodium bicarbonate or can simply be rinsed away with saline if the catalyst is alkaline. The composition may alternatively comprise a group of powerful detergents or surfactants that are known or proven to be effective at removing strongly adhering deposits from objects such as contact lenses. A wide variety of different combinations of detergents or surfactants may be formulated to fulfil this role but it may be necessary to perform a great number of saline rinses before the solution is thereafter effectively removed from the object. The preferred embodiment will comprise a combination of strong surfactants having dimethyl - polysiloxane - polyoxyalkylene together with the appropriate catalyst as the active ingredient.
When using this composition for cleaning contact lenses, a tablet may be formulated comprising a alkaline substance such as sodium bicarbonate and a disinfecting composition such as
H202 (Hydrogen peroxide), chlorhexidine or chlorine. The tablet is dissolved in a measured amount of H20 or saline and then used to neutralize, disinfect and detoxify the lens after cleaning. It may be preferable to include detoxifying compounds in the initial cleaning solution resulting in a composition which will act to prevent the toxic effects of the solution without substantial loss of its suitability for removing proteinaceous and other deposits from contact lenses. The most preferred embodiment is one that combines the deposit removing compounds together with the detoxifying compounds and also includes disinfecting agents which will formulate a completely all in one contact lens solution.
The following examples will serve as an illustration of the invention. Example 1 This composition will not require neutralization
Dimethyl polysiloxane polyoxyalkylene 0.075
Potassium Silanolate 0.050
Example 2
Part (B) of this composition is a tablet prepared on a hand punch to give a tablet of hardness 2.5kg.
(A) Dimethyl polysiloxane polyoxyalkylene 0.075 Akyl carboxylic acid amine condensate 0.050
(B) Sodium Bicarbonate 0.050
Chlorine 0.009
Example 3 Dimethyl polysiloxane polyoxyalkylene 0.075
Polyhydroxyethlmethacrylate 0.040
Carboxymethyl Cellulose 0.200
Polyoxyethylene fatty acid esters 0.075
Chlorine 0.009
When a contact lens containing protein deposits is immersed within said composition of deposit removing compounds and is additionally subjected to the specified ranges of epicyclic movement in a rotational or linear sense, the desired results are actually achieved. Protein film and biofilm layers are quickly and effectively removed and the process will help in the removal of the many other deposits that adhere to an object such as a contact lens. For example the presence of organic protein deposits on a lens may predispose that lens to buildups of inorganic matter such as calcium and the like. By therefore employing this system to protein deposits a great many other deposits may also be reduced and possibly even eliminated. The time required to remove these deposits and rinse them thereafter can be reduced to a time of approximately 30 - 60 seconds when operating at a frequency of 30 - 50 Hz, thus allowing such a regimen to be performed daily. When rinsing the lens, neutralization of the acid catalyst may be achieved by using simple, universal compounds such as sodium bicarbonate although the use of an alkaline catalyst may be preferred.
As has been stated different combinations of surfactants can be used with this embodiment of the invention so long as they are known or are proven to be effective at removing strongly adhering deposits from objects such, as contact lenses. Such a composition may once again only require a conventional rinse using a saline solution. Where only a small amount of the deposits are present, that have not become too strongly adherent to the lens, the lens may be cleaned by digital cleaning methods, i.e. gentle rubbing of the subject solution on the lens surface followed by rinsing. However in most cases it will be desirable to clean the lens using the abovementioned cleaning regimen. After cleaning, the lenses should be placed in a disinfecting and allowed to soak overnight. It will be obvious that changes and modification may be practiced within the invention without departing from the
scope thereof. In this embodiment of the invention the lens to be cleaned is first removed from the eye and then immersed in a vial containing a compound known to be effective at removing proteinaceous deposits from contact lenses. Suitable compounds include the proteolytic enzymes that are non toxic to the eye of the user of the lens. Papain is an enzyme derived from the native green fruit of the tropical pawpaw or melon tree Ccarica papaya) whose clear watery fluid is collected, dried and sieved to produce papain. Other suitable enzymes include trypsin, ficin, subtilisin A, bromelin and other such enzymes known to be effective at removing deposits from contact lenses. Normally the lens would be soaked in this solution for a period in excess of 15 - 30 minutes. It would then be required to rinse the lens very thoroughly thereafter, otherwise residual enzyme solution present on the lens when re-inserted into the eye, will start to attack eye tissues. In the present invention the lens and enzyme solution is subjected to epicyclic movement of 30 - 50 Hz and is then exposed to detoxifying compounds which inactivate the enzyme in a process that can be achieved in 30 - 60 seconds.
The detoxifying compounds may comprise sulfhydryl reagents such as iodocietamide or iodocicetic acids which will react with the free sulfhydryl in the enzyme and lead to inactivation of the papain. Soya bean extracts such as soya bean saponin are also known to be inhibitory. Alternatively carbobenzozy-L-glutamic acids or even Chloromethyl ketones of phenylamine and lyslne may help to detoxify the active ingredient. In certain preparations of papain Aldehyde reagents such as phenlhyyrazine or hydroykmine will be effective. One of the aforementioned compounds can be used in conjunction with Hydrogen peroxide at a concentration of 3%. This composition will rapidly inactivate the enzyme and will also serve as an effective disinfectant with excellent antimicrobial properties. In general the detoxifying compounds will act to minimise the accumulation of enzyme
that adheres to the lens and H202 (Hydrogen peroxide) will reduce the activity of the enzyme to at least 15% of its original activity within one minute.
It should be appreciated that the percentages, quantities and components used in this invention can be modified or used in different combinations. Different deposit removers, inhibitors/detoxifyers or disinfectants may be used in any novel method or combination of methods as disclosed herein. Slight variations may be made to the ingredients or percentages of ingredients without departing from the scope thereof. Thus it would be possible to add calcium sequestering agents if these are deemed necessary. The invention may be used with or without a suitable cleaning apparatus for cleaning objects such as contact lenses also as deemed necessary, and a surfactant or surface active agent such as Fluronic may be added to the tablet or particles if desired.
FOR THEPURPOSESOFINFORMATIONONLY
Codes used to identify States party to the PCT on the front pages of pamphlets publishing international applications under the PCT.
AT Austria ES Spain MG Madagascar
AU Australia FT Finland ML MaU
BB Barbados FR France MR Mauritania
BE Belgium GA Gabon MW Malawi
BF Burkina Fasso GB United Kingdom NL Netherlands
BG Bulgaria HU Hungary NO Norway
BJ Benin rr Italy RO Romania
BR Brazil JP Japan . SD Sudan
CA Canada KP DemocraticPeople's Republic SE Sweden
CF Central African Republic ofKorea SN Senegal
CG Congo KR RepublicofKorea SU Soviet Union
CH Switzerland U Liechtenstein TO Chad
CM Cameroon LK Sri Lanka TG Togo
DE Germany. Federal Republicof UJ Luxembourg US United States of America
DK Denmark MC Monaco
PCT WORLD INTELLECTUAL PROPERTY ORGANIZATION International Bureau
INTERNATIONAL APPLICATION PUBLISHED UNDE-R THE PATENT COOPERATION TREATY (PCT)
(51) International Patent Classification 4 : (11)International Publication Number: WO 89/118 A61L2/00 A3 (43)International Publication Date: 14 December 1989 (14.12.8
(21)International Application Number: PCT/GB89/00559 Published
With international search report
(22)InternationalFilingDate: 22 May 1989 (22.05.89) Before the expiration of the time limit for amending th claims and to be republished in the event ofthe receipt amendments.
(30)Priority data:
8812109.0 23 May 1988 (23.05.88) GB (88) Date of publication of the international search report:
5 April 1990 (05.04.90
(71X72)Applicantand Inventor: IFEJIKA, Charles [GB/GB]; 49 Donaldson Road, London NW66NE (GB).
(81)Designated States: AT (European patent), BE (European patent), CH (European patent), DE (European patent), FR (European patent), GB (European patent), IT (European patent), JP, LU (European patent), NL (European patent), SE (European patent), US.
(54)Title: A METHOD OF REMOVING DEPOSITS FROM OBJECTS SUCH AS CONTACT LENSES
(57)Abstract
An object such as a contact lens is immersed in a solution comprising disinfectants, deposit removers, detoxifying co pounds and neutralizers which react with each otherto clean, disinfect and remove harmful deposits from the lens in an all in on action. The lens is then rinsed briefly before being re-inserted in the eye.
r
FOK THE PURPOSES OF INFORMATION ONLY
Codes used to identify States party to the PCT on the front pages of pamphlets publishing international applications under the PCT.
AT Austria ES Spain MG Madagascar
AU Australia FT Finland ML Mali
BB Barbados FR Fiance MR Mauritania
BE Belgium GA Gabon MW Malawi
BF Burkina Fasso GB United Kingdom NL Netherlands
BG Bufearia HU Hungary NO Norway
Bi Benin rr Italy RO Romania
BR Brazil JP Japan SD Sudan
CA Canada KP Democratic People's Republic SE Sweden
CF Central African Republic of Korea SN Senegal
CG Congo KR Republic of Korea SU Soviet Union
CH Switzerland U Liechtenstein TD Chad
CM Cameroon LK Sri Lanka TG Togo
DE Germany; Federal Republic of Ul Luxembourg US United States of America
DK Denmark MC Monaco
PCT WORLD INTELLECTUAL PROPERTY ORGANIZATION International Bureau
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT)
(51) International Patent Classification 4 (11) International Publication Number: WO 89/11 A61L 2/00 A3 (43) International Publication Date: 14 December 1989 (14.12.
(21) International Application Number : PCT/GB89/00559
(22) International Filing Date: 22 May 1989 (22.05.89) Published
With international search report With amended claims.
(30) Priority data:
8812109.0 23 May 1988 (23.05.88) GB (88) Date of publication of the international search report:
5 April 1990 (05.04.9
(71X72) Applicant and Inventor: IFEJIKA, Charles [GB/GB]; Date of publication of the amended claims: 49 Donaldson Road, London NW6 6NE (GB). 3 May 1990 (03.05.9
(81) Designated States: AT (European patent), BE (European patent), CH (European patent), DE (European patent), FR (European patent), GB (European patent), IT (European patent), JP, LU (European patent), NL (European patent), SE (European patent), US.
(54) Title: A METHOD OF REMOVING DEPOSITS FROM OBJECTS SUCH AS CONTACT LENSES
(57) Abstract
An object such as a contact lens is immersed in a solution comprising disinfectants, deposit removers, detoxifying co pounds and neutralizers which react with each other to clean, disinfect and remove harmful deposits from the lens in an all in o action. The lens is then rinsed briefly before being re-inserted in the eye.
FOR THE PURPOSES OF INFORMATION ONLY
Codes used to identify States party to the PCT on the front pages of pamphlets publishing international applications under the PCT.
AT Austria Ft Finland ML Mali
AU Australia FR France MR Mauritania
BB Barbados GA Gabon MW Malawi
BE Belgium GB United Kingdom NL Netherlands
BF Burkina Fasso HU Hungary NO Norway
BG Bulgaria IT Italy RO Romania
BJ Benin JP Japan SD Sudan
BR Brazil KP Democratic People's: Republic SE Sweden
CF Central African Republic of Korea SN Senegal
CG Congo KR Republic of Korea SU Soviet Union
CH Switzerland U Liechtenstein TD Chad
CM Cameroon LK Sri Lanka TG Togo
DE Germany. Federal Republic of LU Luxembourg US United States of America
DK Denmark MC Monaco
ES Spain MG Madagascar
per WORLD INTELLECTUAL PROPERTY ORGANIZATION International Bureau
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT)
(51) International Patent Classification 4 (11)International Publication Number: WO 89/11 A61L2/00 A3 (43)International Publication Date: 14 December 1989 (14.12
(21) InternationalApplication Number: PCT/GB89/00559
(22)International Filing Date: 22 May 1989 (22.05.89) Published
With international search report With amended claims.
(30)Priority data:
8812109.0 23 May 1988 (23.05.88) GB (88) Date of publication of the international search report:
5 April 1990 (05.04.
(71X72)ApplicantandInventor: IFEJIKA, Charles [GB/GB]; 49 Donaldson Road, London NW66NE (GB). Date of publication of the amended claims:
3 May 1990 (03.05.
(81)Designated States: AT (European patent), BE (European patent), CH (European patent), DE (European patent), FR (European patent), GB (European patent), IT (European patent), JP, LU (European patent), NL (European patent), SE (European patent), US.
(54)Title: A METHOD OF REMOVING DEPOSITS FROM OBJECTS SUCH AS CONTACT LENSES
(57)Abstract
An object such as a contact lens is immersed in a solution comprising disinfectants, deposit removers, detoxifying co pounds and neutralizers which react with eachotherto clean, disinfect and remove harmful deposits fromthe lens in an all in action. The lens is then rinsed briefly before being re-inserted in the eye.
FOR THEPURPOSESOFINFORMATIONONLY
Codes used to identify States party to the PCT on the front pages of pamphlets publishing international applications under the PCT.
AT Austria FI Finland ML Mali
AU Australia FR France MR Mauritania
BB Barbados GA Gabon MW Malawi
BE Belgium GB United Kingdom NL Netherlands
BF Burkina Fasso HU Hungary NO Norway
BG Bulgaria IT Italy RO Romania
BJ Benin JP Japan SD Sudan
BR Brazil KP DemocraticPeople's Republic SE Sweden
CF Central African Republic ofKorea SN Senegal
CG Congo KR RepublicofKorea SU Soviet Union
CH Switzerland Li Liechtenstein TD Chad
CM Cameroon LK Sri Lanka TG Togo
DE Germany, Federal Republicof LU Luxembourg US United States of America
DK Denmark MC Monaco
ES Spain MG Madagascar
Claims
1. A composition and. a method of cleaning and removing deposits from objects such as contact lenses comprising: a) an effective amount of a deposit removing compound which is non toxic to the eyes. b) one or more detoxifying/inhibiting compounds capable of removing the toxic effects of said deposit remover or other cleaning and sterilising agents in said composition. c) disinfecting agents capable of sterilising objects such as contact lenses.
2. A method according to claim 1 in any method or combination of methods as disclosed herein.
3. A method for cleaning and removing deposits from objects such as contact lenses wherein the cleaning agent is a combination of one or more detoxifying compounds together with soaking and disinfecting agents in aqueous solution, whereby said solution cleans, rinses, detoxifies, disinfects and stores the contact lenses safely once harmful deposits have been removed from the objects surface by the action of the deposit remover.
4. The method according to claim 1, 2 or 3 wherein the contact lenses are thereafter received within a cleaning apparatus, said apparatus comprising tank means for receiving one or more pairs of contact lenses, and appropriate means for agitating said tank means in a rotational or linear sense, such that a thorough cleaning of the lenses is effected.
5. A method of cleaning objects such as contact lenses comprising a solution or combination of solutions that either simultaneously or within a predetermined timespan cleans, disinfects and removes harmful deposits from objects such as contact lenses.
6. A method of cleaning, disinfecting and removing harmful deposits from objects such as contact lenses wherein the activity of the deposit remover and disinfectant in said solution is arrested by adding to said solution, before the
lens is freed of harmful deposits, a detoxifyer/inhibitor or neutralizer in the form of a tablet or a plurality of particles and comprising one or more detoxifying/inhibiting compounds which react with the deposit remover and disinfectant to form an aqueous solution that is non toxic to the eyes and has a pH of 6.5 to 8.5.
7. A method according to claim 6 wherein there is a coating encasing said tablet or each of said particles which dissolves gradually in said solution, so as to release one or more inhibiting/detoxifying compounds and other water soluble agents into said solution only after a predetermined period of time has elapsed.
8. A method according to claim 6 or 7 wherein the tablet or plurality of particles additionally comprise effective amounts of non toxic agents or compounds that can be used to sterilize objects such as contact lenses, whereby said released compounds transform said solution into a buffered lens soaking solution in which the object can be safely stored.
9. A tablet or plurality of particles according to claim 6, 7 or 8 additionally comprising effective amounts of non toxic agents that may be used as buffers, stabilizers, lubricants and other agents that can provide extra comfort to the user of the object such as the contact lens.
10. A method according to any one of the preceding claims wherein the lens and the detoxifying/inhibiting compounds are immersed into a predetermined volume of a solution consisting essentially of H202 (Hydrogen peroxide) at a concentration of 3%.
11. A method according to any one of the preceding claims wherein the detoxifyer/inhibitor and the object to be cleaned are placed into said solution simultaneously.
12. A method according to 6 to 10 wherein the detoxifyer/inhibitor also includes an acid and a base which gives off an effervesence when dissolved in said solution to
ensure that all ingredients of said tablet or the particles are evenly distributed.
13. A method of any of the preceding claims, said method comprising the additional steps of sealing the tank means after insertion of the object or the detoxifyer/inhibitor into the tank means containing the appropriate solution.
14. A method according to any one of the preceding claims wherein the deposit remover is a protease or an intensive cleaning agent such as dimethyl polysiloxane polyoxyalkylene or any other deposit remover that is used in the method or combination of methods as disclosed herein.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888812109A GB8812109D0 (en) | 1988-05-23 | 1988-05-23 | Method for daily cleaning & protein deposit removal for contact lenses |
| GB8812109.0 | 1988-05-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1989011878A2 true WO1989011878A2 (en) | 1989-12-14 |
| WO1989011878A3 WO1989011878A3 (en) | 1990-04-05 |
Family
ID=10637348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/GB1989/000559 WO1989011878A2 (en) | 1988-05-23 | 1989-05-22 | A method of removing deposits from objects such as contact lenses |
Country Status (2)
| Country | Link |
|---|---|
| GB (2) | GB8812109D0 (en) |
| WO (1) | WO1989011878A2 (en) |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0384666A2 (en) * | 1989-02-21 | 1990-08-29 | BAUSCH & LOMB INCORPORATED | Method and composition for cleaning and disinfecting contact lenses |
| EP0456467A2 (en) * | 1990-05-09 | 1991-11-13 | Alcon Laboratories, Inc. | Contact lens cleaning and disinfecting with combinations of polymeric quaternary ammonium compounds and enzymes |
| WO1992015334A1 (en) * | 1991-03-04 | 1992-09-17 | Allergan, Inc. | Compositions and methods to clean contact lenses |
| US5306440A (en) * | 1989-10-02 | 1994-04-26 | Allergan, Inc. | Methods for generating chlorine dioxide and compositions for disinfecting |
| US5324447A (en) * | 1989-10-02 | 1994-06-28 | Allergan, Inc. | Method and activator compositions to disinfect lenses |
| US5422029A (en) * | 1993-06-18 | 1995-06-06 | Potini; Chimpiramma | Composition for cleaning contact lenses |
| US5500144A (en) * | 1993-06-18 | 1996-03-19 | Polymer Technology Corporation | Composition for cleaning and wetting contact lenses |
| US5604189A (en) * | 1993-06-18 | 1997-02-18 | Zhang; Hong J. | Composition for cleaning and wetting contact lenses |
| US5630884A (en) * | 1993-06-17 | 1997-05-20 | Allergan | Methods for contact lens cleaning |
| US5648074A (en) * | 1993-05-25 | 1997-07-15 | Allergan | Compositions and methods for disinfecting contact lenses and reducing proteinaceous deposit formation |
| US5736165A (en) * | 1993-05-25 | 1998-04-07 | Allergan | In-the-eye use of chlorine dioxide-containing compositions |
| WO1998025650A2 (en) * | 1996-12-13 | 1998-06-18 | Alcon Laboratories, Inc. | Multi-purpose compositions for cleaning and disinfecting of lenses |
| US5783532A (en) * | 1993-06-17 | 1998-07-21 | Allergan | Enzyme compositions and methods for contact lens cleaning |
| US5919698A (en) * | 1995-09-25 | 1999-07-06 | Novo Nordisk A/S | Disinfection and cleaner of contact lenses |
| US6228323B1 (en) | 1996-12-13 | 2001-05-08 | Alcon Laboratories, Inc. | Multi-purpose compositions containing an alkyl-trypsin and methods of use in contact lens cleaning and disinfecting |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3910296A (en) * | 1973-04-20 | 1975-10-07 | Allergan Pharma | Method of removing proteinaceous deposits from contact lenses |
| US4048122A (en) * | 1976-01-23 | 1977-09-13 | Barnes-Hind Pharmaceuticals, Inc. | Cleaning agents for contact lenses |
| EP0139994A1 (en) * | 1983-08-25 | 1985-05-08 | Allergan, Inc. | Process and kit for disinfection of contact lenses |
| EP0257942A1 (en) * | 1986-08-15 | 1988-03-02 | Hoya Corporation | Use of a cleaning composition for contact lens cleaning |
-
1988
- 1988-05-23 GB GB888812109A patent/GB8812109D0/en active Pending
- 1988-07-14 GB GB888816710A patent/GB8816710D0/en active Pending
-
1989
- 1989-05-22 WO PCT/GB1989/000559 patent/WO1989011878A2/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3910296A (en) * | 1973-04-20 | 1975-10-07 | Allergan Pharma | Method of removing proteinaceous deposits from contact lenses |
| US3910296B1 (en) * | 1973-04-20 | 1987-04-14 | ||
| US4048122A (en) * | 1976-01-23 | 1977-09-13 | Barnes-Hind Pharmaceuticals, Inc. | Cleaning agents for contact lenses |
| EP0139994A1 (en) * | 1983-08-25 | 1985-05-08 | Allergan, Inc. | Process and kit for disinfection of contact lenses |
| EP0257942A1 (en) * | 1986-08-15 | 1988-03-02 | Hoya Corporation | Use of a cleaning composition for contact lens cleaning |
Cited By (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU628926B2 (en) * | 1989-02-21 | 1992-09-24 | Bausch & Lomb Incorporated | Method and composition for cleaning and disinfecting contact lenses |
| EP0384666A3 (en) * | 1989-02-21 | 1991-01-23 | BAUSCH & LOMB INCORPORATED | Method and composition for cleaning and disinfecting contact lenses |
| EP0384666A2 (en) * | 1989-02-21 | 1990-08-29 | BAUSCH & LOMB INCORPORATED | Method and composition for cleaning and disinfecting contact lenses |
| US5096607A (en) * | 1989-02-21 | 1992-03-17 | Bausch & Lomb Incorporated | Method for cleaning and disinfecting contact lenses |
| US5324447A (en) * | 1989-10-02 | 1994-06-28 | Allergan, Inc. | Method and activator compositions to disinfect lenses |
| US5306440A (en) * | 1989-10-02 | 1994-04-26 | Allergan, Inc. | Methods for generating chlorine dioxide and compositions for disinfecting |
| US5338480A (en) * | 1989-10-02 | 1994-08-16 | Allegan, Inc. | Compositions and methods to clean contact lenses |
| EP0456467A3 (en) * | 1990-05-09 | 1993-01-20 | Alcon Laboratories Inc | Contact lens cleaning and disinfecting with combinations of polymeric quaternary ammonium compounds and enzymes |
| EP0456467A2 (en) * | 1990-05-09 | 1991-11-13 | Alcon Laboratories, Inc. | Contact lens cleaning and disinfecting with combinations of polymeric quaternary ammonium compounds and enzymes |
| WO1992015334A1 (en) * | 1991-03-04 | 1992-09-17 | Allergan, Inc. | Compositions and methods to clean contact lenses |
| US5736165A (en) * | 1993-05-25 | 1998-04-07 | Allergan | In-the-eye use of chlorine dioxide-containing compositions |
| US5648074A (en) * | 1993-05-25 | 1997-07-15 | Allergan | Compositions and methods for disinfecting contact lenses and reducing proteinaceous deposit formation |
| US6165954A (en) * | 1993-06-17 | 2000-12-26 | Allergan, Inc. | Enzyme compositions and methods for contact lens cleaning |
| US5783532A (en) * | 1993-06-17 | 1998-07-21 | Allergan | Enzyme compositions and methods for contact lens cleaning |
| US5746838A (en) * | 1993-06-17 | 1998-05-05 | Allergan | Enzyme compositions and methods for contact lens cleaning |
| US5630884A (en) * | 1993-06-17 | 1997-05-20 | Allergan | Methods for contact lens cleaning |
| US5604189A (en) * | 1993-06-18 | 1997-02-18 | Zhang; Hong J. | Composition for cleaning and wetting contact lenses |
| US5607908A (en) * | 1993-06-18 | 1997-03-04 | Wilmington Partners L.P. | Composition for cleaning contact lenses |
| US5773396A (en) * | 1993-06-18 | 1998-06-30 | Polymer Technology Corporation | Contact lens cleaning and wetting solutions containing a non-amine polyethyleneocy adduct having a HLB value of at least about 18, a surface active agent having a HLB of less than 18, and wetting agent |
| US5500144A (en) * | 1993-06-18 | 1996-03-19 | Polymer Technology Corporation | Composition for cleaning and wetting contact lenses |
| US5422029A (en) * | 1993-06-18 | 1995-06-06 | Potini; Chimpiramma | Composition for cleaning contact lenses |
| US5919698A (en) * | 1995-09-25 | 1999-07-06 | Novo Nordisk A/S | Disinfection and cleaner of contact lenses |
| WO1998025650A2 (en) * | 1996-12-13 | 1998-06-18 | Alcon Laboratories, Inc. | Multi-purpose compositions for cleaning and disinfecting of lenses |
| WO1998025650A3 (en) * | 1996-12-13 | 1998-11-12 | Alcon Lab Inc | Multi-purpose compositions for cleaning and disinfecting of lenses |
| US6228323B1 (en) | 1996-12-13 | 2001-05-08 | Alcon Laboratories, Inc. | Multi-purpose compositions containing an alkyl-trypsin and methods of use in contact lens cleaning and disinfecting |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1989011878A3 (en) | 1990-04-05 |
| GB8812109D0 (en) | 1988-06-29 |
| GB8816710D0 (en) | 1988-08-17 |
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