WO1989010091A1 - Device for taking specimens, in particular for histological examination of human organs - Google Patents

Device for taking specimens, in particular for histological examination of human organs Download PDF

Info

Publication number
WO1989010091A1
WO1989010091A1 PCT/HU1988/000022 HU8800022W WO8910091A1 WO 1989010091 A1 WO1989010091 A1 WO 1989010091A1 HU 8800022 W HU8800022 W HU 8800022W WO 8910091 A1 WO8910091 A1 WO 8910091A1
Authority
WO
WIPO (PCT)
Prior art keywords
needle
cutting tube
spring
cutting
sampling device
Prior art date
Application number
PCT/HU1988/000022
Other languages
German (de)
French (fr)
Inventor
Sándor LOVÁSZ
Original Assignee
Zalaform Kft.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zalaform Kft. filed Critical Zalaform Kft.
Priority to PCT/HU1988/000022 priority Critical patent/WO1989010091A1/en
Publication of WO1989010091A1 publication Critical patent/WO1989010091A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A61B10/0266—Pointed or sharp biopsy instruments means for severing sample
    • A61B10/0275—Pointed or sharp biopsy instruments means for severing sample with sample notch, e.g. on the side of inner stylet

Definitions

  • the invention relates to a biopsy sampling device for the histological examination of various organs (liver, muscle, kidney, prostate gland, etc.), with the aid of which an adjustable amount of tissue sample can be easily taken, the device can be removed using only one hand, with a significantly increased accuracy .
  • tissue samples in order to determine the nature of the disease, to determine the diagnosis, tissue samples must be taken from the organs to be examined, and information about the curability of the disease and the type of treatment can be obtained on the basis of these tissue samples using various examination methods .
  • the course or the degree of progress of various diseases is controlled by repeated sampling.
  • the oldest method of sampling is surgery, whereby the tissue sample to be examined is removed from the organ by an open operation that is extremely stressful for the patient.
  • a more modern and widespread method today is the so-called sampling with a biopsy needle.
  • a variant of this method is the sampling with the so-called Tru-Cut needle from TRAVENOL, whereby without an open operation, i.e. without major intervention, a thin tube with a sharp end edge, the diameter of which is approximately 2 mm, has a sharp cutting edge at its tip and in its end region with a lateral recess, a needle with a diameter of approximately 1.5 mm is inserted into the organ to be examined.
  • the desired puncture depth ie the organ to be examined or its specific part
  • the depth of the tube is fixed with one hand and the inner needle, the so-called stylet, is advanced with the other hand. Then the position of the stylet is fixed and the previously fixed tube with the cutting edge is pushed onto the stylet with a quick movement.
  • the tissue cylinder to be examined which has penetrated into the recess in this way, is cut off and this can be pulled out of the cutter with the stylet, or the whole can be removed together.
  • One of the main disadvantages is that both hands of the doctor performing the procedure are required to use this device, so that in certain areas of application such as when taking samples from the prostate when penetrating through the perineum or rectum, the organ-supporting function of one hand fails and the position of the biopsy needle cannot be checked at the moment of cutting. This has the consequence - especially if the stitch is to be moved to a smaller area described in more detail - that the probability of being hit is reduced.
  • the biopsy needle consists of the fact that there is no supportive - targeted physical contact between the patient and the doctor performing the procedure, especially at the moment of cutting, so that if the cutting edge is suddenly pushed forward, it can accidentally cause serious injury to the vital neighboring organs, e.g. one Prostate biopsy is the injury to the bladder and intestines, in the case of a kidney and liver biopsy the injury to the intestines and / or the large veins supplying these organs with blood.
  • Another disadvantage of this method is that when the cutting edge is suddenly pushed forward, the stylet - due to its inadequate fixation - is inevitably moved backwards, which reduces the size of the tissue cylinder that can be cut out.
  • Another major disadvantage of this method is that the cutting process (the excision) is relatively slow, so that the tissues partially jam in front of the cutting edge and so only a minimal amount of test material can be obtained. In some cases - in the case of tissues with a loose structure - the tissue is pushed out of the cutout of the stylet by the cutting edge and in this way the attempt to take the sample remains unsuccessful.
  • US Pat. No. 4,256,119 describes a biopsy needle construction, the stylet (inner needle) of which, together with the tissue sample removed thereby, is torn back into the interior of the cutting tube provided with a sharp end edge by a tension spring.
  • This solution also has the disadvantage that both hands are required to operate it and a large part of the tissues during the return of the stylet to its original one Position before the stitch returned, so that only a very small amount of tissue sample can be obtained through a relatively large excision and destruction.
  • the aim of the invention is to remedy the shortcomings of the known solutions, that is to say to ensure the operation of the device with only one hand, to aim more precisely, to reduce the risk to vital organs and at the same time to obtain a sufficiently large tissue sample - if necessary with a continuous touch account - roll through the other hand.
  • the invention is based on the knowledge that the sampling can also be carried out with one hand and the advancing of the tube provided with the cutting edge can be omitted if an external force source which ensures a movement of adjustable length is used to move the tube.
  • such a device for taking samples from organs for histological examination, which has a needle in a cutting tube provided with a cutting edge at one end thereof and / or can be moved independently of it and in its one end region it contains a recess for the tissue sample and has a needle moving handle attached to the other end of the needle.
  • the other end of the cutting tube is provided with a stop collar, and on the needle section between the needle-moving handle and the stop collar there is a spring which is subjected to pressure, the cutting tube having an element which limits the axial overflow.
  • the device can be produced with optimal dimensions if a steel coil spring is used as the spring a spring constant of 0.1 m / kg is used.
  • the advancement of the cutting tube that is to say the rapid excision of the tissue sample, is started with the aid of a trigger bar which can be pressed on with the hand holding the device.
  • a toothed bar movable by a toothed segment is attached to the end of the cutting tube and a leaf spring provided with hooks is attached to the end of the needle.
  • the toothed segment can be fastened to the release bar and a screw that adjusts the stroke length can be arranged at the end of the toothed segment.
  • the overflow of the cutting tube that is to say the damage to the other parts of the organism to be protected, which are located behind the organs to be examined, can advantageously be prevented with the aid of a limiting end face which determines the stroke length and is formed in the needle-moving handle.
  • FIG. 1 is a side view of a sampling device according to the invention
  • FIG. 2 shows the rear of the sampling device according to Fig.1
  • Fig. 3 shows the top view of the sampling device
  • Fig. 1 partially in section
  • Fig. 4 is a side view of a sampling device with a pistol grip.
  • a cutting tube 1 the lower end of which is provided with a stop collar 16, is located in a plastic-made handle of a sampling device according to the invention.
  • a needle 2 with sharp cutting edges at its tip 3, the lower end of which is attached to a needle-moving handle 21.
  • the handle 21 is provided with an end surface 21a which receives the palm pressure.
  • a helical spring 17 is arranged on the section of the needle 2 between the stop collar 16 and the handle 21, the spring constant of which was chosen to exert a force of at least 0.5 N to a value of 0. m / kg.
  • a stop screw 9 is embedded, at the front end face of which is provided with a limiting groove 12 - rod 11.
  • the axial movement of the stop screw 9 can be achieved with the aid of the position-adjusting nut 10 arranged thereon.
  • the slipping out of the handle 21 moving from the handle 8 is prevented by a limiting screw 7 located behind the handle 21.
  • An element 18 limiting the end position is fastened to the needle-moving handle 21 and one is the overflow in the handle 8 of the cutting tube 1 preventing end face 25 is formed.
  • the advanced position of the needle is fixed by the stroke length-adjusting bolt 15 which is stuck in the limiting groove 12 and which can be pivoted about the axis 13 by pressing in a push button 15a.
  • the needle 2 can be advanced during a gripping movement by pressing the end face 21a.
  • the middle finger of the right hand should be placed in the handle 23a shown in FIG.
  • Fig. 3 shows in detail the formed at the front end of the cutting tube 1 cutting edge 6 and the needle tip 3 at the front end of the needle 2. Behind the sharp cutting needle tip 3 is formed on the needle 2, a recess 5 for the tissue sample, which is actually an axial Represents flattening of the needle body.
  • the handle 23a receiving the middle finger of the right hand is located symmetrically to the handle 23b.
  • a stop collar 16 is fastened to the end of the cutting tube 1.
  • a helical spring 17 is arranged on the section of the needle 2 between the stop collar 16 and the handle 21.
  • the advanced position of the needle 2 can be stopped in the limiting groove 12 by stopping the stroke-length-adjusting bolt 15 are locked, the bolt 15 is held in a locking (locking) position by a winding on the axis 13 and supported on the handle 8 or on the side surface of the stroke-length-adjusting bolt 15.
  • the pushing of the cutting tube 1 can be started by the push button 19a.
  • the push button 19a is located on the side of the release bar 19 which can be pivoted about the axis 24.
  • the release bar 19 is pressed in the rest position by a spring 20 against the stop collar 16 and by pressing the push button 19a it is possible for the cutting tube 1 to be moved by the spring 17 can be advanced. A possible overflow of the cutting tube 1 is prevented by a boundary face 25.
  • the device shown in FIG. 4 differs from the exemplary embodiment described above in that the handle 8 looks similar to a pistol handle, the trigger bar 19 of which can be pivoted about the axis 24.
  • a toothed segment 27 is fastened in the trigger bar 19, while a toothed rack 26 is fastened to the needle 2.
  • a leaf spring 28 provided with a hook 29 is connected to the end of the cutting tube 1.
  • a screw 30 which adjusts the stroke length is arranged at the rear section of the handle 8, a window 31 allowing the movement of the screw 30 is provided.
  • the stroke length ie the size of the sample to be examined, is set to 1 cm e with the position-adjusting nut 10 Thereafter, the entire length of the needle 2 is pushed into the cutting tube 1 when the push button 15a is pressed.
  • the stroke length can of course also be set larger or smaller as desired.
  • the needle 2 located in the cutting tube 1 is to be inserted at a depth by grasping the handle 8 with the right hand into the, for example bulging organ to be examined, so that the tip 3 of the needle 2 reaches the tumor (the tumor).
  • the index finger of the right hand is placed on the handle 23b, while the middle finger is placed on the handle 23a, and the end face 21a of the needle-moving handle 21 is pushed forward with the palm until the stroke-length-adjusting bolt 15 gets stuck in the limiting groove 12.
  • the needle 2 extends in the predetermined length of 1 cm into the tumor and part of the tumor penetrates into the recess 5 of the needle 2.
  • the advance of the handle 21 simultaneously causes the spring 17 to be compressed.
  • the handle 8 should also be gripped from below with the right hand and the push button 19a pressed with the thumb, as a result of which the release latch 19 releases the stop collar 16 and the spring 17 releases it
  • the cutting tube 1 pushes forward, as a result of which the tumor part which has penetrated into the recess 5 is cut off by the cutting edge 6 of the cutting tube 1.
  • the tissue sample is taken with the embodiment of the sampling device according to the invention shown in FIG. 4 in such a way that with one hand the pistol grip-like handle 8 is firmly inserted into the cutting tube 1 receiving the needle 2 as far as the organ to be examined. Thereafter, the needle 2 is pushed forward by pulling the trigger bar 19 through the toothed segment 27 together with the toothed strip 26 and after reaching the through the. stroke length-adjusting screw 30 of predetermined depth, the screw 30 extending through the window 31 moves the hook 29 of the leaf spring 28. Accordingly, the envy tube 1 is released and pushed forward by the spring 17 and the tissue sample to be examined is paced through the cutting tube 1. In the end position of the cutting, the stop collar 16 of the cutting tube 1 is stopped by the limiting face 25 of the handle 8.
  • the device containing the tissue sample can be pulled out of the tumor or from the examined organ and the tissue sample obtained in this way can be subjected to the known histological examinations.
  • the sampling device according to the invention can be operated with one hand; when used, the risk of damage to the other organs located near the organ to be examined is practically completely eliminated and with continuous tactile control by the other A quick excision of a tissue sample with a preset size is guaranteed by hand.

Abstract

A device for taking biopsy specimens, in particular for histological examination of human organs, comprises a cutting tube (1) with a cutting edge (6) at one end and a recess (5) in its end region for the movable needle (2) containing the tissue specimens; a handle (21) secured to the other end of the needle (2) which moves said needle; and a spring (17) which alters the relative positions of the needle (2) and the cutting tube (1). A stopping collar (16) is arranged at the other end of the cutting tube (1), the pressure-loaded spring (17) is arranged on the section of the needle (2) between the handle (21) which moves the needle and the stopping collar (16), and the cutting tube (1) has a limiting front face (25) which prevents excess travel of said tube. A rack (26) moved by a toothed segment (27) is advantageously mounted on the end of the needle (2) and a leaf spring (28) provided with hooks is advantageously mounted on the end of the cutting tube (1). A screw (30) which co-operates with the leaf spring for adjusting the incremental advance of the needle (2) is provided at the end of the toothed segment (27).

Description

PROBENENTNAHMEVORRICHTUNG, INSBESONDERE ZUR HISTOLOGISCHEN UNTERSUCHUNG VON MENSCHLICHEN ORGANEN SAMPLING DEVICE, IN PARTICULAR FOR HISTOLOGICAL EXAMINATION OF HUMAN ORGANS
Die Erfindung betrifft eine biopsiche Probenentnahmevorrichtung zur histologischen Untersuchung von verschiedenen Organen (Leber, Muskel, Niere, Vorsteherdrüse usw.), mit deren Hilfe eine einstellbare Menge von Gewebeprobe leicht, die Vorrichgung nur mit einer Hand betätigend entnommen werden kann, bei einer wesentlich erhöhten Treffgenauigkeit.The invention relates to a biopsy sampling device for the histological examination of various organs (liver, muscle, kidney, prostate gland, etc.), with the aid of which an adjustable amount of tissue sample can be easily taken, the device can be removed using only one hand, with a significantly increased accuracy .
Es ist bekannt, dass zum Zweck der Feststellung der Natur der Krankheit, zur Bestimmung der Diagnose Gewebeproben aus den zu untersuchenden Organen entnommen werden müssen und anhand dieser Gewebeproben mit verschiedenen Untersuchungsmethoden Informationen bezüglich der Heilbarkeit der Krankheit und der Art und Weise der Behandlung gewonnen werden können. Der Ablauf bzw. der Fortgeschrittenheitsgrad von verschiedenen Krankheiten wird durch wiederholte Probenentnahmen, kontrolliert.It is known that in order to determine the nature of the disease, to determine the diagnosis, tissue samples must be taken from the organs to be examined, and information about the curability of the disease and the type of treatment can be obtained on the basis of these tissue samples using various examination methods . The course or the degree of progress of various diseases is controlled by repeated sampling.
Die älteste Probenentnahmemethode ist die Operation, wobei die zu untersuchende Gewebeprobe durch eine den Patienten stark belastende offene Operation dem Organ entnommen wird.The oldest method of sampling is surgery, whereby the tissue sample to be examined is removed from the organ by an open operation that is extremely stressful for the patient.
Eine modernere und auch heutzutage weit verbreitete Methode ist die sogenannte Probenentnahme mit Biopsienadel. Eine Variante dieser Methode ist die Probenentnahme mit der sogenannten Tru-Cut-Nadel der Firma TRAVENOL, wobei ohne offene Operation, also ohne grösseren Eingriff mit einem dünnen Rohr scharfer Endkante zusammen, dessen Durchmesser etwa 2 mm beträgt, eine an ihrer Spitze scharfe Schneiden aufweisende und in ihrem Endbereich mit einer seitlichen Aussparung versehene Nadel mit einem Durchmesser von etwa 1,5 mm in das zu untersuchende Organ gestochen wird. Nach dem Erreichen der gewünschten Einstichtiefe, d.h. des zu untersuchenden Organs bzw. dessen bestimmten Teiles wird mit einer Hand die Tiefenlage des Rohres fixiert und mit der anderen Hand wird die innere Nadel, das sogenannte Mandrin vorgeschoben. Danach wird die Lage des Mandrins fixiert und das bisher fixierte, mit Schneidkante versehene Rohr mit einer raschen Bewegung auf das Mandrin daraufgeschoben.A more modern and widespread method today is the so-called sampling with a biopsy needle. A variant of this method is the sampling with the so-called Tru-Cut needle from TRAVENOL, whereby without an open operation, i.e. without major intervention, a thin tube with a sharp end edge, the diameter of which is approximately 2 mm, has a sharp cutting edge at its tip and in its end region with a lateral recess, a needle with a diameter of approximately 1.5 mm is inserted into the organ to be examined. After reaching the desired puncture depth, ie the organ to be examined or its specific part, the depth of the tube is fixed with one hand and the inner needle, the so-called stylet, is advanced with the other hand. Then the position of the stylet is fixed and the previously fixed tube with the cutting edge is pushed onto the stylet with a quick movement.
Der in dieser Weise in die Aussparung eingedrungene, zu untersuchende Gewebezylinder wird abgeschnitten und dies kann mit dem Mandrin zusammen aus dem Schneiderchr herausgezogen, oder das Ganze zusammen entfernt werden.The tissue cylinder to be examined, which has penetrated into the recess in this way, is cut off and this can be pulled out of the cutter with the stylet, or the whole can be removed together.
Diese Probenentnahmemethode ermöglicht zwar, dass die für die Untersuchung unbedingt notwendige Gewebeprobe geringer Menge ohne besondere Zerstörung und grösseren Operationseingriff aus den Organen entnommen werden kann, ihre Anwendung ist jedoch mit mehreren Nachteilen verbunden.Although this sampling method enables the tissue sample, which is absolutely necessary for the examination, to be taken from the organs without special destruction and major surgical intervention, its use is associated with several disadvantages.
Einer der wichtigsten Nachteile besteht darin, dass zur Benutzung dieses Gerätes beide Hände des den Eingriff durchführenden Arztes benötigt werden, so dass bei bestimmten Anwendungsgebieten wie z.B. bei der Probenentnahme aus der Prostata beim Eindrigen durch den Damm oder den Mastdarm die organunterstützende Funktion der einen Hand ausfällt und gerade im Augenblick des Schneidens die Lage der Biopsienadel nicht kontrolliert werden kann. Das hat - insbesondere, wenn der Stich in einen näher beschriebenen, geringeren Bereich versetzt werden soll - die Verminderung der Treffwahrscheinlichkeit zur Folge.One of the main disadvantages is that both hands of the doctor performing the procedure are required to use this device, so that in certain areas of application such as when taking samples from the prostate when penetrating through the perineum or rectum, the organ-supporting function of one hand fails and the position of the biopsy needle cannot be checked at the moment of cutting. This has the consequence - especially if the stitch is to be moved to a smaller area described in more detail - that the probability of being hit is reduced.
Ein anderer Nachteil der die beiden Hände in Anspruch neh menden Biopsienadel besteht darin, dass gerade im Augenblick des Schneidens kein unterstützender - zielender Körperkontakt zwischen dem Patienten und dem den Eingriff durchführenden Arzt besteht, so dass beim plötzlichen Vorstossen der Schneid kante diese zufällig eine schwere Verletzung der lebenswichtigen benachbarten Organe verursachen kann, z.B. bei einer Prostatabiopsie die Verletzung der Harnblase und der Därme, bei einer Nieren- und Leberbiopsie die Verletzung der Därme und/oder der diese Organe mit Blut versorgenden grossen Adern. Ein weiterer Nachteil dieser Methode besteht darin, dass beim plötzlichen Vorstossen der Schneidkante das Mandrin - infolge seiner nicht ausreichenden Fixierung - unvermeidlich nach hinten verschoben wird, wodurch die Grosse des ausschneidbaren Gewebezylinders vermindert wird.Another disadvantage of using the two hands The biopsy needle consists of the fact that there is no supportive - targeted physical contact between the patient and the doctor performing the procedure, especially at the moment of cutting, so that if the cutting edge is suddenly pushed forward, it can accidentally cause serious injury to the vital neighboring organs, e.g. one Prostate biopsy is the injury to the bladder and intestines, in the case of a kidney and liver biopsy the injury to the intestines and / or the large veins supplying these organs with blood. Another disadvantage of this method is that when the cutting edge is suddenly pushed forward, the stylet - due to its inadequate fixation - is inevitably moved backwards, which reduces the size of the tissue cylinder that can be cut out.
Ein bedeutender Nachteil dieser .Methode ist weiterhin, dass der Schneidvorgang (die Exzision) relativ langsam vor sich geht, so dass die Geweben sich teilweise vor der Schneidkante stauen und so nur eine minimale Menge von Prüfstoff gewonnen werden kann. In einigen Fällen - bei Geweben lockerer Struktur - wird das Gewebe durch die Schneidkante aus der Aussparung des Mandrins herausgedrückt und in dieser Weise bleibt der Versuch der Probenentnahme erfolglos.Another major disadvantage of this method is that the cutting process (the excision) is relatively slow, so that the tissues partially jam in front of the cutting edge and so only a minimal amount of test material can be obtained. In some cases - in the case of tissues with a loose structure - the tissue is pushed out of the cutout of the stylet by the cutting edge and in this way the attempt to take the sample remains unsuccessful.
In der US-PS 4 256 119 wird eine Biopsienadelkonstruktion beschrieben, deren Mandrin (innere Nadel) zusammen mit der durch dieses entnommenen Gewebeprobe durch eine Zugfeder in das Innere des mit scharfer Endkante versehenen Schneiderohr zurückgerissen wird.US Pat. No. 4,256,119 describes a biopsy needle construction, the stylet (inner needle) of which, together with the tissue sample removed thereby, is torn back into the interior of the cutting tube provided with a sharp end edge by a tension spring.
Diese Lösung hat auch den Nachteil, dass bei ihrer Betätigung beide Hände benötigt werden und ein grosser Teil der Geweben während der Zurückstellung des Mandrins in seine ursprüngliche Lage vor dem Stich zurückgelangt, so dass durch eine relativ grosse Exzision und Zerstörung nur eine äusserst geringe Menge von Gewebeprobe gewonnen werden kann.This solution also has the disadvantage that both hands are required to operate it and a large part of the tissues during the return of the stylet to its original one Position before the stitch returned, so that only a very small amount of tissue sample can be obtained through a relatively large excision and destruction.
Das Ziel der Erfindung ist die Behebung der Mängel der bekannten Lösungen, also die Gewährleistung der Betätigung der Vorrichtung nur mit einer Hand, ein genaueres Zielen, die Verminderung der Gefährdung von lebenswichtigen Organen und gleichzeitig die Gewinnung einer genügend grossen Gewebeprobe - notwendigerfalls bei einer kontinuierlichen Tastkont- rolle durch die andere Hand.The aim of the invention is to remedy the shortcomings of the known solutions, that is to say to ensure the operation of the device with only one hand, to aim more precisely, to reduce the risk to vital organs and at the same time to obtain a sufficiently large tissue sample - if necessary with a continuous touch account - roll through the other hand.
Der Erfindung liegt die Erkenntnis zugrunde, dass die Proben- entnahme auch mit einer Hand durchgeführt werden kann und das mit Hand erfolgende Vorstossen des mit Schneidkante versehenen Rohres entfallen kann, wenn zur Bewegung des Rohres eine äussere, eine Bewegung eintellbarer Länge gewährleistende Kraftquelle eingesetzt wird.The invention is based on the knowledge that the sampling can also be carried out with one hand and the advancing of the tube provided with the cutting edge can be omitted if an external force source which ensures a movement of adjustable length is used to move the tube.
Aufgrund dieser Erkenntnis wird zur Probenentnahme aus Organen zur histologischen Untersuchung eine solche Vorrichtung vorgeschlagen, die eine in einem an seinem einen Ende mit einer Schneidkante versehenen Schneiderohr damit zusammen und/oder davon unabhängig bewegbare und in ihrem einen Endbereich eine Aussparu für die Gewebeprobe enthaltende Nadel sowie einen am anderen Ende der Nadel befestigten nadelbewegenden Griff aufweist. Erfindungsgemäss ist das andere Ende des Schneiderohres mit einem Anschlagbund versehen, und auf dem Nadelabschnitt zwischen dem nadelbewegenden Griff und dem Anschlagbund befindet sich eine auf Druck beanspruchte Feder, wobei das Schneiderohr ein das axiale Überlaufen begrenzendes Element aufweist.On the basis of this knowledge, such a device is proposed for taking samples from organs for histological examination, which has a needle in a cutting tube provided with a cutting edge at one end thereof and / or can be moved independently of it and in its one end region it contains a recess for the tissue sample and has a needle moving handle attached to the other end of the needle. According to the invention, the other end of the cutting tube is provided with a stop collar, and on the needle section between the needle-moving handle and the stop collar there is a spring which is subjected to pressure, the cutting tube having an element which limits the axial overflow.
Die Vorrichtung kann mit optimalen Abmessungen hergestellt werden, wenn als Feder eine Schraubenfeder aus Stahl mit einer Federkonstante von 0,1 m/kg verwendet wird.The device can be produced with optimal dimensions if a steel coil spring is used as the spring a spring constant of 0.1 m / kg is used.
Zur Gewährleistung der einfachen, mit einer Hand erfolgenden Betätigung ist es zweckmässig, wenn das Vorstossen des Schneiderohres, also die schnelle Exzision der Gewebeprobe mit Hilfe eines mit der die Vorrichtung haltenden Hand andrückbaren Auslöseriegel gestartet wird.To ensure simple operation with one hand, it is expedient if the advancement of the cutting tube, that is to say the rapid excision of the tissue sample, is started with the aid of a trigger bar which can be pressed on with the hand holding the device.
Aus diesem Zweck ist es vorteilhaft, wenn am Ende des Schneiderohres eine durch ein Zahnsegment bewegbare Zahnleiste und am Ende der Nadel eine mit Haken versehene Blattfeder befestigt ist. In diesem Fall kann das Zahnsegment am Auslöse riegel befestigt werden und am Ende des Zahnsegmentes kann eine die Hublänge einstellende Schraube angeordnet werden.For this purpose, it is advantageous if a toothed bar movable by a toothed segment is attached to the end of the cutting tube and a leaf spring provided with hooks is attached to the end of the needle. In this case, the toothed segment can be fastened to the release bar and a screw that adjusts the stroke length can be arranged at the end of the toothed segment.
DAs Überlaufen des Schneiderohres, also die Beschädigung der sich hinter den zu untersuchenden Organen befindlichen anderen zu behütenden Teilen des Organismus kann vorteilhafterweise mit Hilfe einer die Hublänge bestimmenden Begrenzungsstirnf lache verhindert werden, die im nadelbewegenden Griff ausgebildet ist.The overflow of the cutting tube, that is to say the damage to the other parts of the organism to be protected, which are located behind the organs to be examined, can advantageously be prevented with the aid of a limiting end face which determines the stroke length and is formed in the needle-moving handle.
Die Erfindung wird ausführlicher anhand der beigefügten Zeichnung erläutert. In der Zeichnung erläutert. In der Zeichnung, wo die gleichen Bezugsnummern gleiche Bestandteile bezeichnen, sind mögliche Ausführungsbeispiele der erfindungsgemässen Probenentnahmevorrichtung dargestellt.The invention will be explained in more detail with reference to the accompanying drawing. Explained in the drawing. In the drawing, where the same reference numbers designate the same components, possible exemplary embodiments of the sampling device according to the invention are shown.
In der Zeichung zeigenShow in the drawing
Fig. 1 die Seitenansicht einer erfindungsgemässen Probenentnahmevorrichtung,1 is a side view of a sampling device according to the invention,
Fig. 2 die Hinter an sieht der Probenentnahmevorrichtung nach Fig.1, Fig. 3 die Draufsicht der Probenentnahmevorricht ung nach2 shows the rear of the sampling device according to Fig.1, Fig. 3 shows the top view of the sampling device
Fig. 1, teilweise im Schnitt, und Fig. 4 die Seitenansicht einer Probenentnahmevorrichtung mit einem Pistolengriff.Fig. 1, partially in section, and Fig. 4 is a side view of a sampling device with a pistol grip.
Wie es aus Fig. 1 ersichtlich ist, befindet sich in einem aus Kunststoff gefertigten Handgriff einer erfindungsgemäss Proben entn ahmevorrichtung ein Schneiderohr 1, dessen untere Ende mit einem Anschlagbund 16 versehen ist. Im Inneren des Schneiderohres verläuft eine an ihrer Spitze 3 scharfe Schneiden aufweisende Nadel 2, deren unteres Ende zu einem nadelbewegenden Griff 21 befestigt ist. Der Griff 21 ist mit einer den Handtellerdruck aufnehmenden Stirnfläche 21a versehen. Auf dem Abschnitt der Nadel 2 zwischen dem Anschlagbund 16 und dem Griff 21 ist eine Schraubenlinienförmige Feder 17 angeordnet, deren Federkonstante zur Ausübung einer Kraft von mindestens 0,5 N auf einen Wert von 0, m/kg gewählt wurde. In dem nadelbewegenden Griff 21 ist dre eine Anschlagschraube 9 eingebettet, an deren vorderen Stir fläche eine mit einer Begrenzungsnut 12- versehene Begrenzun stange 11 befestigt ist.As can be seen from FIG. 1, a cutting tube 1, the lower end of which is provided with a stop collar 16, is located in a plastic-made handle of a sampling device according to the invention. Inside the cutting tube runs a needle 2 with sharp cutting edges at its tip 3, the lower end of which is attached to a needle-moving handle 21. The handle 21 is provided with an end surface 21a which receives the palm pressure. A helical spring 17 is arranged on the section of the needle 2 between the stop collar 16 and the handle 21, the spring constant of which was chosen to exert a force of at least 0.5 N to a value of 0. m / kg. In the needle-moving handle 21, a stop screw 9 is embedded, at the front end face of which is provided with a limiting groove 12 - rod 11.
Die axiale Bewegung der Anschlagschraube 9 kann mit Hilfe der daran angeordneten lageneinstellenden Mutter 10 erreicht werden.The axial movement of the stop screw 9 can be achieved with the aid of the position-adjusting nut 10 arranged thereon.
Das Hinausgleiten des hadelbewegenden Griffes 21 aus dem Hand-griff 8 wird durch eine sich hinter dem Griff 21 befindlich Begrenzungsschraube 7 verhindert.The slipping out of the handle 21 moving from the handle 8 is prevented by a limiting screw 7 located behind the handle 21.
Zum nadelbewegenden Griff 21 ist ein die Endlage begrenzendes Element 18 befestigt und im Handgriff 8 -ist eine das Überlaufen des Schneiderohres 1 verhindernde Stirnfläche 25 ausgebildet.An element 18 limiting the end position is fastened to the needle-moving handle 21 and one is the overflow in the handle 8 of the cutting tube 1 preventing end face 25 is formed.
Die vorgeschobene Lage der Nadel wird durch den in der Begrenzungsnut 12 steckenbleibenden hublängerneinstellenden Riegel 15 fixiert, der um die Achse 13 durch Eindrücken eines Druckknopfes 15a verschwenkbar ist.The advanced position of the needle is fixed by the stroke length-adjusting bolt 15 which is stuck in the limiting groove 12 and which can be pivoted about the axis 13 by pressing in a push button 15a.
Der Vorschub der Nadel 2 kann nach dem Hineinlegen des Zeigefingers der rechten Hand in den Griff 23b während einer greifenden Bewegung durch Drücken der Stirnfläche 21a durchgeführt werden. Gleichzeitig soll der Mittelfinger der rechten Hand in den aus Fig.3 ersichtlichen Griff 23a hineingelegt werden.After the index finger of the right hand is inserted into the handle 23b, the needle 2 can be advanced during a gripping movement by pressing the end face 21a. At the same time, the middle finger of the right hand should be placed in the handle 23a shown in FIG.
Aus der Hinteransicht in Fig. 2. ist ersichtlich, dass der nadelbewegende Griff 21 beim Vorschub der Nadel 2 auf einer schlittenführenden Gleitbahn 22 bewegt wird und das Vorstossen des Schneidrohres 1 durch den Druckknopf 19a gestartet werden kann.From the rear view in FIG. 2 it can be seen that the needle-moving handle 21 is moved when the needle 2 is advanced on a slide-guiding slideway 22 and the advancement of the cutting tube 1 can be started by the push button 19a.
Fig. 3 zeigt ausführlich die am vorderen Ende des Schneiderohres 1 ausgebildete Schneidkante 6 sowie die Nadelspitze 3 am vorderen Ende der Nadel 2. Hinter der scharfe Schneiden aufweisnden Nadelspitze 3 ist and der Nadel 2 eine Aussparung 5 für die Gewebeprobe ausgebildet, die eigentlich eine axiale Abflachung des Nadelkörpers darstellt. Symmetrisch zum Griff 23b befindet sich der den Mittelfinger der rechten Hand aufnehmende Griff 23a. Zum Ende des Schneiderohres 1 ist ein Anschlagbund 16 befestigt. Auf dem Abschnitt der Nadel 2 zwischen dem Anschlagbund 16 und dem Griff 21 ist eine schraubenlinienformige Feder 17 angeordnet.Fig. 3 shows in detail the formed at the front end of the cutting tube 1 cutting edge 6 and the needle tip 3 at the front end of the needle 2. Behind the sharp cutting needle tip 3 is formed on the needle 2, a recess 5 for the tissue sample, which is actually an axial Represents flattening of the needle body. The handle 23a receiving the middle finger of the right hand is located symmetrically to the handle 23b. A stop collar 16 is fastened to the end of the cutting tube 1. A helical spring 17 is arranged on the section of the needle 2 between the stop collar 16 and the handle 21.
Die vorgeschobene Lage der Nadel 2 kann durch Aufhalten des hublängeneinstellenden Riegels 15 in der Begrenzungsnut 12 arretiert werden, wobei der Riegel 15 durch eine auf die Achse 13 gewundene und auf dem Handgriff 8 bzw. an der Seitenfläche des hublängeneinstellenden Riegels 15 abgestützte Rastfeder 14 in verriegelnder (arretierender) Lage gehalten wird.The advanced position of the needle 2 can be stopped in the limiting groove 12 by stopping the stroke-length-adjusting bolt 15 are locked, the bolt 15 is held in a locking (locking) position by a winding on the axis 13 and supported on the handle 8 or on the side surface of the stroke-length-adjusting bolt 15.
Nach dem Eindringen der Gewebeprobe in die Aussparung 5 kann das Vorstossen des Schneiderohres 1 durch den Druckknopf 19a gestartet werden. Der Druckknopf 19a befindet sich an der Seite des um die Achse 24 verschwenkbaren Auslöseriegels 19. Der Auslöseriegel 19 wird in Ruhelage durch eine Feder 20 an den Anschlagbund 16 gedrückt und durch Drücken des Druckknopfes 19a wird es ermöglicht, dass das Schneiderohr 1 durch die Feder 17 vorgestossen werden kann. Ein eventuelles Überlaufen des Schneiderohres 1 wird durch eine Begrenzungsstirnfläche 25 verhindert.After the tissue sample has penetrated into the recess 5, the pushing of the cutting tube 1 can be started by the push button 19a. The push button 19a is located on the side of the release bar 19 which can be pivoted about the axis 24. The release bar 19 is pressed in the rest position by a spring 20 against the stop collar 16 and by pressing the push button 19a it is possible for the cutting tube 1 to be moved by the spring 17 can be advanced. A possible overflow of the cutting tube 1 is prevented by a boundary face 25.
Die in Fig. 4 dargestellte Vorrichtung unterscheidet sich von dem oben beschriebenen Ausführungsbeispiel darin, dass der Handgriff 8 einem Pistolenhandgriff ähnlich aussieht, dessen Auslöseriegel 19 um die Achse 24 verschwenkbar ist. Im Auslöseriegel 19 ist ein Zahnsegment 27, während an der Nadel 2 eine Zahnstange 26 befestigt. An das Ende des Schneiderohres 1 ist eine mit einem Haken 29 versehene Blattfeder 28 angeschlössen. Am Ende des Zahnsegmentes 27 ist eine die Hublänge einstellende Schraube 30 angeordnet. Am hinteren Abschnitt des Handgriffes 8 ist ein die Bewegung der Schraube 30 erlaubendes Fenster 31 vorgesehen.The device shown in FIG. 4 differs from the exemplary embodiment described above in that the handle 8 looks similar to a pistol handle, the trigger bar 19 of which can be pivoted about the axis 24. A toothed segment 27 is fastened in the trigger bar 19, while a toothed rack 26 is fastened to the needle 2. A leaf spring 28 provided with a hook 29 is connected to the end of the cutting tube 1. At the end of the toothed segment 27, a screw 30 which adjusts the stroke length is arranged. At the rear section of the handle 8, a window 31 allowing the movement of the screw 30 is provided.
Die Arbeitsweise der Probenentnahmevorrichtung gemäss Fig.1-3 ist wie folgt:The method of operation of the sampling device according to Fig. 1-3 is as follows:
Mit der lageeinstellenden Mutter 10 wird die Hublänge, d.h. die Grosse der zu untersuchenden Probe auf 1 cm e ingestellt Danach wird beim Drücken des Druckknopfes 15a die Nadel 2 in ihrer ganzen Länge in das Schneiderohr 1 hineingeschoben. Die Hublänge kann selbstverständlich wunschgemäss auch grösser oder kleiner eingestellt werden. Die sich im Schneiderohr 1 befindliche Nadel 2 soll durch Anfassung des Handgriffes 8 mit der rechten Hand in das zu untersuchende , z.B. gewulstige Organ in einer Tiefe hineingestochen werden, damit die Spitze 3 der Nadel 2 die Geschwulst (den Tumor) erreicht. Danach wird der Zeigefinger der rechten Hand auf den Griff 23b, während der Mittelfinger auf den Griff 23a gelegt und mit dem Handteller wird die Stirnfläche 21a des nadelbewegenden Griffes 21 solange nach vorn geschoben, bis der hublängeneinstellende Riegel 15 in der Begrenzungsnut 12 steckenbleibt. Dabei reicht die Nadel 2 in der im voraus bestimmten Länge von 1 cm in die Geschwulst hinein und ein Teil der Geschwulst dringt in die Aussparung 5 der Nadel 2 ein. Der Vorschub des Griffes 21 bewirkt gleichzeitig das Zusammendrücken der Feder 17. Danach soll der Handgriff 8 ebenfalls mit der rechten Hand von unten angefasst werden und der Druckknopf 19a mit dem Daumen gedrückt werden, infolgedessen der Auslöseriegel 19 den Anschlagbund 16 freigibt und die Feder 17 das Schneiderohr 1 nach vorne stosst, wodurch der in die Aussparung 5 hineingedrungene Geschwulstteil durch die Schneidkante 6 des Schneiderohres 1 abgeschnitten wird.The stroke length, ie the size of the sample to be examined, is set to 1 cm e with the position-adjusting nut 10 Thereafter, the entire length of the needle 2 is pushed into the cutting tube 1 when the push button 15a is pressed. The stroke length can of course also be set larger or smaller as desired. The needle 2 located in the cutting tube 1 is to be inserted at a depth by grasping the handle 8 with the right hand into the, for example bulging organ to be examined, so that the tip 3 of the needle 2 reaches the tumor (the tumor). Then the index finger of the right hand is placed on the handle 23b, while the middle finger is placed on the handle 23a, and the end face 21a of the needle-moving handle 21 is pushed forward with the palm until the stroke-length-adjusting bolt 15 gets stuck in the limiting groove 12. The needle 2 extends in the predetermined length of 1 cm into the tumor and part of the tumor penetrates into the recess 5 of the needle 2. The advance of the handle 21 simultaneously causes the spring 17 to be compressed. Thereafter, the handle 8 should also be gripped from below with the right hand and the push button 19a pressed with the thumb, as a result of which the release latch 19 releases the stop collar 16 and the spring 17 releases it The cutting tube 1 pushes forward, as a result of which the tumor part which has penetrated into the recess 5 is cut off by the cutting edge 6 of the cutting tube 1.
Die Entnahme der Gewebeprobe erfolgt mit der in Fig. 4 dargestellten Ausführungsform der erf indungsgemässen Probenentnahmevorrichtung in der Weise, dass mit der einen Hand den pistolengriffähnlichen Handgriff 8 festhaltend das die Nadel 2 aufnehmende Schneiderohr 1 bis zum zu untersuchenden Organ hineingestochen wird. Danach wird die Nadel 2 beim Ziehen des Auslöseriegels 19 durch das Zahnsegment 27 zusammen mit der Zahnleiste 26 nach vorn geschoben und nach dem Erreichen der durch die. hublängeneinstellenden Schraube 30 vorbestimmten Tiefe verschiebt die durch das Fenster 31 hindurchreichende Schraube 30 den Haken 29 der Blattfeder 28. Demzufolge wird das neiderohr 1 freigegeben und durch die Feder 17 vorgestossen und die zu untersuchende Gewebeprobe wird durch das Schneiderohr 1 abgeschritten. In der Endlage des Schneidens wird der Anschlagbund 16 des Schneiderohrεs 1 durch die Begrenzungsstirnflache 25 des Handgriffes 8 aufgehalten.The tissue sample is taken with the embodiment of the sampling device according to the invention shown in FIG. 4 in such a way that with one hand the pistol grip-like handle 8 is firmly inserted into the cutting tube 1 receiving the needle 2 as far as the organ to be examined. Thereafter, the needle 2 is pushed forward by pulling the trigger bar 19 through the toothed segment 27 together with the toothed strip 26 and after reaching the through the. stroke length-adjusting screw 30 of predetermined depth, the screw 30 extending through the window 31 moves the hook 29 of the leaf spring 28. Accordingly, the envy tube 1 is released and pushed forward by the spring 17 and the tissue sample to be examined is paced through the cutting tube 1. In the end position of the cutting, the stop collar 16 of the cutting tube 1 is stopped by the limiting face 25 of the handle 8.
Nach diesem in einigen Sekunden durchgeführten Vorgang kann die die Gewebeprobe enthaltende Vorrichtung aus der Geschwulst bzw. aus dem untersuchten Organ herausgezogen werden und die so gewonnene Gewebeprobe kann den bekannten histologischen Untersuchungen untergeworfen werden.After this process, which is carried out in a few seconds, the device containing the tissue sample can be pulled out of the tumor or from the examined organ and the tissue sample obtained in this way can be subjected to the known histological examinations.
Wie es aus den beschriebenen Beispielen hervorgeht, kann die erfindungsgemässe Probenentnahmevorrichtung mit einer Hand betätigt werden, bei ihrem Einsatz wird die Gefahr der Beschädigung der sich In der Nähe des zu untersuchenden, Organs befindlichen anderen Organe praktisch völlig behoben und bei einer kontinuierlichen Tastkontrolle durch die andere Hand wird eine schnelle Exzision einer Gewebeprobe mit im voraus eingestellten Grosse gewährleistet. As can be seen from the examples described, the sampling device according to the invention can be operated with one hand; when used, the risk of damage to the other organs located near the organ to be examined is practically completely eliminated and with continuous tactile control by the other A quick excision of a tissue sample with a preset size is guaranteed by hand.

Claims

PA TEN TANSPRÜCHE PA TEN CLAIMS
1. Probenentnahmevorrichtung, insbesondere zur histologischen Untersuchung von menschlichen Organen, mit einer in einem an seinem einen Ende mit einer Schneidkante versehenen Schneiderohr mit dem Schneiderohr zusammen und/oder davon unabhängig bewegbaren und in ihrem einen Endbereich eine Aussparung für die Gewebeprobe enthaltenden Nadel, einem am anderen Ende der Nadel befestigten nadelbewegenden Griff sowie mit einem die gegenseitige Lage der Nadel und des Schneiderohres ändernden energiespeicherndem Element, vorteilhafterweise einer Feder, dadurch gekennzeichnet , dass das andere Ende des Schneiderohres (1) mit einem Anschlagbund (16) versehen ist, die druckbeanspruchte Feder (17) auf dem Abschnitt der Nadel (2) zwischen dem nadelbewegenden Griff (21) und dem Anschlagbund (16) angeordnet ist, ausserdem das Schneiderohr (1) eine sein Überlaufen behindernde Begrenzungsstirnflache (25) aufweist.1. Sampling device, in particular for the histological examination of human organs, with a cutting tube provided with a cutting edge in one end with a cutting edge and / or movable independently of it and in its one end region containing a recess for the tissue sample, an am the other end of the needle attached needle moving handle and with an energy-storing element changing the mutual position of the needle and the cutting tube, advantageously a spring, characterized in that the other end of the cutting tube (1) is provided with a stop collar (16), the compression spring (17) is arranged on the section of the needle (2) between the needle-moving handle (21) and the stop collar (16), moreover the cutting tube (1) has a limiting end face (25) which prevents it from overflowing.
2. Probenentnahmevorrichtung nach Anspruch 1, dadurc h gekennzeichnet , dass die Feder (17) eine Schraubenfeder aus Stahl ist, deren Federkonstante höchstens 0,1 m/kg beträgt.2. Sampling device according to claim 1, characterized in that the spring (17) is a coil spring made of steel, the spring constant of which is at most 0.1 m / kg.
3. Probenentnahmevorrichtung nach Anspruch 1 oder 2, dadurch gekennzeichnet , dass das Schneiderohr (1) einen sein Vorstossen erlaubenden Auslöseriegel (19) aufweist.3. Sampling device according to claim 1 or 2, characterized in that the cutting tube (1) has a trigger bar allowing its advance (19).
4. Probenentnahmevorrichtung nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet , dass am Ende des Schneiderohres (1) eine durch ein Zahnradsegment (27) bewegbare Zahnleiste (26) befestigt ist. 4. Sampling device according to one of claims 1 to 3, characterized in that at the end of the cutting tube (1) by a gear segment (27) movable toothed bar (26) is attached.
5. Probenentnahmevorrichtung nach einem der Ansprüche 1 bis 4, d adurch gekennzeichnet , dass am Ende der Nadel (2) eine mit Haken (29) versehene Blattfeder (28) befestigt ist.5. Sampling device according to one of claims 1 to 4, characterized in that a leaf spring (28) provided with hooks (29) is attached to the end of the needle (2).
6. Probenentnahmevorrichtung nach einem der Ansprüche 1 bis 5, dadurch gekennzeichnet, dass das Zahnsegment (27) am Auslöseriegel (19) befestigt ist und am Ende des Zahnsegmentes eine hublängeneinstellende Schraube (30) vorgesehen ist. 6. Sampling device according to one of claims 1 to 5, characterized in that the toothed segment (27) is fastened to the trigger bar (19) and a stroke-length-adjusting screw (30) is provided at the end of the toothed segment.
PCT/HU1988/000022 1988-04-19 1988-04-19 Device for taking specimens, in particular for histological examination of human organs WO1989010091A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/HU1988/000022 WO1989010091A1 (en) 1988-04-19 1988-04-19 Device for taking specimens, in particular for histological examination of human organs

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/HU1988/000022 WO1989010091A1 (en) 1988-04-19 1988-04-19 Device for taking specimens, in particular for histological examination of human organs

Publications (1)

Publication Number Publication Date
WO1989010091A1 true WO1989010091A1 (en) 1989-11-02

Family

ID=10980795

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU1988/000022 WO1989010091A1 (en) 1988-04-19 1988-04-19 Device for taking specimens, in particular for histological examination of human organs

Country Status (1)

Country Link
WO (1) WO1989010091A1 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5127419A (en) * 1991-07-02 1992-07-07 Antoine Kaldany Biopsy instrument with slotted driving member
FR2688681A1 (en) * 1992-03-23 1993-09-24 Lebosse Guy Universal handle for coeliosurgery instrumentation
US5358474A (en) * 1991-07-02 1994-10-25 Intermed, Inc. Subcutaneous drug delivery device
WO1995022943A1 (en) * 1994-02-24 1995-08-31 Medl Maximilian J Tissue resection forceps for treating teat canal stenoses
US5562613A (en) * 1991-07-02 1996-10-08 Intermed, Inc. Subcutaneous drug delivery device
US5830153A (en) * 1994-04-26 1998-11-03 Kass; Erik S. Controlled surgical core biopsy system
US6659996B1 (en) 1995-11-09 2003-12-09 Intermed, Inc. Device for delivering biological agents

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD141108A1 (en) * 1978-12-28 1980-04-16 Heinz Kuhn EXZISIONSINSTRUMENT
EP0153047A2 (en) * 1984-02-10 1985-08-28 Dan Beraha Transrectal prostate biopsy device
WO1987006815A1 (en) * 1986-05-14 1987-11-19 Dan Beraha Biopsy instrument

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD141108A1 (en) * 1978-12-28 1980-04-16 Heinz Kuhn EXZISIONSINSTRUMENT
EP0153047A2 (en) * 1984-02-10 1985-08-28 Dan Beraha Transrectal prostate biopsy device
WO1987006815A1 (en) * 1986-05-14 1987-11-19 Dan Beraha Biopsy instrument

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5127419A (en) * 1991-07-02 1992-07-07 Antoine Kaldany Biopsy instrument with slotted driving member
US5358474A (en) * 1991-07-02 1994-10-25 Intermed, Inc. Subcutaneous drug delivery device
US5501664A (en) * 1991-07-02 1996-03-26 Intermed, Inc. Subcutaneous drug delivery device
US5562613A (en) * 1991-07-02 1996-10-08 Intermed, Inc. Subcutaneous drug delivery device
FR2688681A1 (en) * 1992-03-23 1993-09-24 Lebosse Guy Universal handle for coeliosurgery instrumentation
WO1995022943A1 (en) * 1994-02-24 1995-08-31 Medl Maximilian J Tissue resection forceps for treating teat canal stenoses
US5830153A (en) * 1994-04-26 1998-11-03 Kass; Erik S. Controlled surgical core biopsy system
US6659996B1 (en) 1995-11-09 2003-12-09 Intermed, Inc. Device for delivering biological agents

Similar Documents

Publication Publication Date Title
DE69530130T2 (en) BIOPSY INSTRUMENT FOR ENDOSCOPIC TAKING OF MULTIPLE SAMPLES
DE849592C (en) Bisturi
EP1156746B1 (en) Instrument for cutting biological and notably human tissue
DE69825249T2 (en) APPLICATOR FOR MOUNTING A SURGICAL CLIP IN TISSUE
DE602006000798T2 (en) Device for protecting a pointed end of a cannula and method for using the same device
DE60203598T2 (en) DEVICE FOR TAKING TISSUE SAMPLES
DE4306277C2 (en) Operation marking tool
DE69432971T2 (en) TROCAR AND CANNULA
DE69633750T2 (en) Device for automatic biopsy and soft tissue removal
DE19510455B4 (en) Surgical instrument for the abrupt insertion of an intraosseous trocar needle
DE3403962C2 (en)
EP0010321A1 (en) Device for the single-handed operation of a biopsy instrument
DE935625C (en) Excision device
DE102012221109B4 (en) Surgical instrument and handle for a surgical instrument
CH624291A5 (en)
DE10026683A1 (en) Surgical stapling device
DE2430970C3 (en) Surgical clip for connecting ends of severed tubular body organs, one end of which is everted and the other end is pulled over the everted end, and device for using this clip
DE10223558A1 (en) System useful in withdrawing blood for diagnostic purposes, has housing, lancet guide and lancet drive provided with drive spring, cocking device, drive rotor and outputs side coupling mechanism
EP0742695B1 (en) Microsurgery instrument
DE2544262A1 (en) Catheter for intra:uterine use - has puncturing point and protective and removable hose in longitudinal central channel
DE112008003820T5 (en) One-body Lancet and Painless Blood Collection Device
DE60107590T2 (en) SURGICAL CLASS INSTRUMENT
EP0843536B1 (en) Surgical instrument
DE2453058A1 (en) Excision head for tissue sample removal in vivo - has sliding knife which cuts tissue protruding through aperture in casing wall
DE102005023414B3 (en) Cardiac surgical puncture catheter has outer sheath around a screw catheter for surgical needle with end-stop puncture limiter

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE FR GB IT LU NL SE