WO1988009808A3 - Receptor-based biosensors - Google Patents

Receptor-based biosensors Download PDF

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Publication number
WO1988009808A3
WO1988009808A3 PCT/US1988/001853 US8801853W WO8809808A3 WO 1988009808 A3 WO1988009808 A3 WO 1988009808A3 US 8801853 W US8801853 W US 8801853W WO 8809808 A3 WO8809808 A3 WO 8809808A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor
analyte
based biosensors
polymeric film
determining
Prior art date
Application number
PCT/US1988/001853
Other languages
French (fr)
Other versions
WO1988009808A2 (en
Inventor
Richard F Taylor
Ingrid G Marenchic
Edward J Cook
Original Assignee
Little Inc A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Little Inc A filed Critical Little Inc A
Publication of WO1988009808A2 publication Critical patent/WO1988009808A2/en
Publication of WO1988009808A3 publication Critical patent/WO1988009808A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/817—Enzyme or microbe electrode
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier

Abstract

A method of immobilizing and stabilizing an active biological receptor in a polymeric film and receptor-based biosensors for determining an analyte of interest in a sample. The receptor-based biosensors include a polymeric film having a biological receptor capable of binding an analyte of interest immobilized therein according to the method of the present invention and an electrical means for determining the presence and quantity of the analyte. In particular, acetylcholine receptor and opiate receptor have been immobilized in a polymeric film made by combining the receptor, a material (e.g., bovine serum albumin, gelatin) capable of polymerizing and a polymerizing agent (e.g., glutaraldehyde).
PCT/US1988/001853 1987-06-05 1988-06-01 Receptor-based biosensors WO1988009808A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US058,389 1987-06-05
US07/058,389 US5001048A (en) 1987-06-05 1987-06-05 Electrical biosensor containing a biological receptor immobilized and stabilized in a protein film

Publications (2)

Publication Number Publication Date
WO1988009808A2 WO1988009808A2 (en) 1988-12-15
WO1988009808A3 true WO1988009808A3 (en) 1989-04-06

Family

ID=22016510

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1988/001853 WO1988009808A2 (en) 1987-06-05 1988-06-01 Receptor-based biosensors

Country Status (4)

Country Link
US (1) US5001048A (en)
EP (1) EP0367788A1 (en)
JP (1) JPH02503826A (en)
WO (1) WO1988009808A2 (en)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5132402A (en) * 1987-11-25 1992-07-21 Agency Of Industrial Science And Technology Adsorbent, method for production thereof, and method for use thereof
US5594113A (en) 1988-06-23 1997-01-14 Associates Of Cape Cod, Inc. Endotoxin binding and neutralizing protein and uses thereof
US5063081A (en) * 1988-11-14 1991-11-05 I-Stat Corporation Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor
IT1229691B (en) * 1989-04-21 1991-09-06 Eniricerche Spa SENSOR WITH ANTIGEN CHEMICALLY LINKED TO A SEMICONDUCTIVE DEVICE.
US5328847A (en) * 1990-02-20 1994-07-12 Case George D Thin membrane sensor with biochemical switch
WO1992020715A1 (en) * 1991-05-16 1992-11-26 Associates Of Cape Cod, Inc. Endotoxin binding and neutralizing protein and uses thereof
JPH0634596A (en) * 1992-07-20 1994-02-08 Fujitsu Ltd Oxygen electrode, biosensor and manufacture thereof
US5547555A (en) * 1993-02-22 1996-08-20 Ohmicron Technology, Inc. Electrochemical sensor cartridge
WO1994025862A1 (en) * 1993-05-04 1994-11-10 Washington State University Research Foundation Biosensor substrate for mounting bilayer lipid membrane containing a receptor
WO1995008637A1 (en) * 1993-09-21 1995-03-30 Washington State University Research Foundation Immunoassay comprising ligand-conjugated, ion channel receptor immobilized in lipid film
AU705351B2 (en) * 1994-11-10 1999-05-20 Orchid Biosciences, Inc. Liquid distribution system
US5603351A (en) * 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
SE510733C2 (en) 1995-01-03 1999-06-21 Chemel Ab Chemical sensor based on interchangeable recognition component and its use
US20120160687A1 (en) 1995-03-17 2012-06-28 President And Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US6362002B1 (en) * 1995-03-17 2002-03-26 President And Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
DE19512117A1 (en) 1995-04-04 1996-10-10 Itt Ind Gmbh Deutsche Measuring device
US5698083A (en) * 1995-08-18 1997-12-16 Regents Of The University Of California Chemiresistor urea sensor
US5958791A (en) * 1996-09-27 1999-09-28 Innovative Biotechnologies, Inc. Interdigitated electrode arrays for liposome-enhanced immunoassay and test device
US6358752B1 (en) 1996-09-27 2002-03-19 Cornell Research Foundation, Inc. Liposome-enhanced test device and method
DE19640092A1 (en) * 1996-09-28 1998-04-16 Beiersdorf Ag Structures with lipid double membranes, in the lipophilic area of which longer-chain molecules are immersed or which are docked to such molecules through hydrophobic interactions
GB9622304D0 (en) 1996-10-26 1996-12-18 Univ Manchester Sensor
US5922537A (en) * 1996-11-08 1999-07-13 N.o slashed.AB Immunoassay, Inc. Nanoparticles biosensor
CA2282433A1 (en) * 1997-03-03 1998-09-11 Deborah Charych Direct colorimetric detection of biocatalysts
US5948694A (en) * 1997-04-07 1999-09-07 Motorola, Inc. Molecular detection apparatus
US5882931A (en) * 1997-07-14 1999-03-16 Petersen; Roger Method and apparatus for performing urinalysis in real time
CN100337106C (en) * 1997-09-11 2007-09-12 生物风险公司 Method of making high density arrays
US6001239A (en) * 1998-09-30 1999-12-14 Mercury Diagnostics, Inc. Membrane based electrochemical test device and related methods
DE19822123C2 (en) 1997-11-21 2003-02-06 Meinhard Knoll Method and device for the detection of analytes
WO1999060399A1 (en) * 1998-05-21 1999-11-25 Cornell Research Foundation, Inc. Liposome-enhanced test device and method
GB9812783D0 (en) 1998-06-12 1998-08-12 Cenes Ltd High throuoghput screen
US6692696B1 (en) * 1998-06-18 2004-02-17 ARETé ASSOCIATES Biosensor
US6267872B1 (en) 1998-11-06 2001-07-31 The Regents Of The University Of California Miniature support for thin films containing single channels or nanopores and methods for using same
WO2000064539A1 (en) 1999-04-26 2000-11-02 U.S. Army Medical Research And Materiel Command Method to make op detoxifying sponges
ATE253091T1 (en) 1999-04-26 2003-11-15 Us Army Med Res Mat Command DIFFERENTIATE FUNCTIONING SPONGES FOR DETOXIFICATION OF SURGICAL COMPOUNDS
US6485690B1 (en) 1999-05-27 2002-11-26 Orchid Biosciences, Inc. Multiple fluid sample processor and system
CA2375532A1 (en) 1999-06-23 2000-12-28 Cornell Research Foundation, Inc. Dehydration/rehydration of marked liposomes on a test device
US6576460B1 (en) 1999-10-28 2003-06-10 Cornell Research Foundation, Inc. Filtration-detection device and method of use
CA2393733A1 (en) * 1999-12-09 2001-06-14 Motorola, Inc. Methods and compositions relating to electrical detection of nucleic acid reactions
US6518024B2 (en) 1999-12-13 2003-02-11 Motorola, Inc. Electrochemical detection of single base extension
AU2001236625A1 (en) * 2000-02-01 2001-08-14 Motorola, Inc. Detection and differentiation of bacteria using electrical detection methods
US6824669B1 (en) 2000-02-17 2004-11-30 Motorola, Inc. Protein and peptide sensors using electrical detection methods
US20040094414A1 (en) * 2000-03-30 2004-05-20 Manfred Engelhardt Biosensor, biosensor array, method for producing an electrode of a biosensor , method for producing a biosensor
US6406876B1 (en) 2000-04-26 2002-06-18 The United States Of America As Represented By The Secretary Of The Army Immobilized enzymes biosensors for chemical toxins
US7008524B2 (en) 2000-10-03 2006-03-07 Hrl Laboratories, Llc Sensors with variable response behavior
US6835552B2 (en) * 2000-12-14 2004-12-28 The Regents Of The University Of California Impedance measurements for detecting pathogens attached to antibodies
US7022218B2 (en) * 2001-05-29 2006-04-04 Matsushita Electric Industrial Co., Ltd. Biosensor with interdigitated electrodes
US20030104428A1 (en) * 2001-06-21 2003-06-05 President And Fellows Of Harvard College Method for characterization of nucleic acid molecules
WO2003081223A2 (en) * 2001-08-29 2003-10-02 Hrl Laboratories, Llc Sensors with variable response behavior
GB0203053D0 (en) * 2002-02-08 2002-03-27 Ayanda Biosystems Sarl Bio-sensors
EP1939627B1 (en) 2002-05-31 2010-08-18 Cornell Research Foundation, Inc. Methods to detect analytes in samples
US7468255B2 (en) * 2002-12-20 2008-12-23 Acea Biosciences Method for assaying for natural killer, cytotoxic T-lymphocyte and neutrophil-mediated killing of target cells using real-time microelectronic cell sensing technology
US7470533B2 (en) * 2002-12-20 2008-12-30 Acea Biosciences Impedance based devices and methods for use in assays
US8206903B2 (en) 2002-12-20 2012-06-26 Acea Biosciences Device and method for electroporation-based delivery of molecules into cells and dynamic monitoring of cell responses
US8263375B2 (en) 2002-12-20 2012-09-11 Acea Biosciences Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology
US7560269B2 (en) * 2002-12-20 2009-07-14 Acea Biosciences, Inc. Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays
CN100487133C (en) * 2002-07-20 2009-05-13 艾森生物(杭州)有限公司 Testing apparatuses and methods based impedance
US7732127B2 (en) 2002-12-20 2010-06-08 Acea Biosciences, Inc. Dynamic monitoring of cell adhesion and spreading using the RT-CES system
US20040110205A1 (en) * 2002-09-23 2004-06-10 Hui Wang Methods and systems for nanopore data analysis
US10215748B2 (en) 2002-12-20 2019-02-26 Acea Biosciences, Inc. Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways
US10539523B2 (en) 2002-12-20 2020-01-21 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties
US11346797B2 (en) 2002-12-20 2022-05-31 Agilent Technologies, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties
US10551371B2 (en) 2003-11-10 2020-02-04 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function
US20040248287A1 (en) * 2003-03-28 2004-12-09 Qianjin Hu Multi-array systems and methods of use thereof
KR100554649B1 (en) * 2003-06-09 2006-02-24 주식회사 아이센스 Electrochemical biosensor
WO2005017025A2 (en) 2003-08-15 2005-02-24 The President And Fellows Of Harvard College Study of polymer molecules and conformations with a nanopore
US20050054025A1 (en) * 2003-09-09 2005-03-10 Rogers Kim R. Stabilized enzymes for detecting and monitoring chemical toxins
US7276351B2 (en) 2003-09-10 2007-10-02 Seahorse Bioscience Method and device for measuring multiple physiological properties of cells
JP4458802B2 (en) * 2003-10-02 2010-04-28 パナソニック株式会社 Method for measuring glucose in blood and sensor used therefor
US8658349B2 (en) 2006-07-13 2014-02-25 Seahorse Bioscience Cell analysis apparatus and method
CA2550274A1 (en) * 2003-11-12 2005-05-26 Acea Biosciences, Inc. Real time electronic cell sensing systems and applications for cell-based assays
US7238485B2 (en) 2004-03-23 2007-07-03 President And Fellows Of Harvard College Methods and apparatus for characterizing polynucleotides
US20060194198A1 (en) * 2004-06-29 2006-08-31 Carlo Licata Use of fibrous protein fibers for chemical sensing and radiation detection
JP2007003439A (en) * 2005-06-27 2007-01-11 Hitachi Software Eng Co Ltd Manufacturing method of biosensor
US8041515B2 (en) * 2006-09-20 2011-10-18 Acea Biosciences, Inc. Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents
CA2723223C (en) 2008-05-05 2017-06-06 Acea Biosciences, Inc. Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution
JP2011067766A (en) 2009-09-25 2011-04-07 Ricoh Co Ltd Method for manufacturing powder and fluidized bed-type crusher
US9910040B2 (en) 2012-07-09 2018-03-06 Sevident, Inc. Molecular nets comprising capture agents and linking agents
US9733242B2 (en) 2012-10-07 2017-08-15 Sevident, Inc. Devices for capturing analyte
WO2011146531A1 (en) 2010-05-18 2011-11-24 Acea Biosciences, Inc Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (rtca) cardio instruments
CN103154729B (en) 2010-06-08 2015-01-07 哈佛大学校长及研究员协会 Nanopore device with graphene supported artificial lipid membrane
US9903830B2 (en) 2011-12-29 2018-02-27 Lifescan Scotland Limited Accurate analyte measurements for electrochemical test strip based on sensed physical characteristic(s) of the sample containing the analyte
CN104471052B (en) 2012-11-13 2017-06-13 海马生物科学公司 For the apparatus and method of the three-dimensional tissue's measurement based on control media flow
DE102013008243A1 (en) 2013-05-15 2014-11-20 Kimal Plc Probe for measuring biomolecules by means of electrochemical impedance spectroscopy
US9243276B2 (en) 2013-08-29 2016-01-26 Lifescan Scotland Limited Method and system to determine hematocrit-insensitive glucose values in a fluid sample
US9459231B2 (en) 2013-08-29 2016-10-04 Lifescan Scotland Limited Method and system to determine erroneous measurement signals during a test measurement sequence
DE102013217359A1 (en) * 2013-08-30 2015-03-05 Fachhochschule Aachen biosensor
US10118177B2 (en) 2014-06-02 2018-11-06 Seahorse Bioscience Single column microplate system and carrier for analysis of biological samples
WO2018161063A1 (en) 2017-03-03 2018-09-07 Acea Biosciences, Inc. METHODS AND SYSTEMS FOR FUNCTIONAL MATURATION OF iPSC AND ESC DERIVED CARDIOMYOCYTES
USD941488S1 (en) 2020-02-07 2022-01-18 Agilent Technologies, Inc. Instrument for analyzing biological cells
USD1021136S1 (en) 2021-12-14 2024-04-02 Agilent Technologies, Inc. Booster plate

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1318815A (en) * 1970-06-08 1973-05-31 Miles Lab Specific chemical probes
GB2136130A (en) * 1983-02-28 1984-09-12 Theodore Henry Krueger Chemical Assay Systems
WO1984003945A1 (en) * 1983-03-26 1984-10-11 Cambridge Life Sciences Conductimetric bioassay techniques
WO1987003095A1 (en) * 1985-11-19 1987-05-21 The Johns Hopkins University/Applied Physics Labor Capacitive sensor for chemical analysis and measurement

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4004979A (en) * 1968-03-29 1977-01-25 Agence Nationale De Valorisation De La Recherche (Anvar) Preparation of active proteins cross-linked to inactive proteins
US3833894A (en) * 1973-06-20 1974-09-03 Ibm Organic memory device
US4078049A (en) * 1977-02-28 1978-03-07 Hoffmann-La Roche Inc. Acetylcholine assay
US4229537A (en) * 1978-02-09 1980-10-21 New York University Preparation of trichloro-s-triazine activated supports for coupling ligands
JPS5548392A (en) * 1978-02-17 1980-04-07 Toyo Jozo Co Ltd Novel immobilizing material combined with biologically active substance, its preparation, device comprising it, method, and preparation of support
JPS5510590A (en) * 1978-05-04 1980-01-25 Wellcome Found Enzyme immunity quantity analysis
US4344438A (en) * 1978-08-02 1982-08-17 The United States Of America As Represented By The Department Of Health, Education And Welfare Optical sensor of plasma constituents
JPS6029475B2 (en) * 1978-09-29 1985-07-10 株式会社日立製作所 Immobilized enzyme membrane and its manufacturing method
DE2842862A1 (en) * 1978-10-02 1980-04-10 Boehringer Mannheim Gmbh METHOD FOR DETERMINING ION, POLAR AND / OR LIPOPHILE SUBSTANCES IN LIQUIDS
JPS56115727A (en) * 1980-02-19 1981-09-11 Kuraray Co Ltd Carrier for immobilizing physiologically active substance
US4324858A (en) * 1980-06-16 1982-04-13 Midwest Research Institute Stabilization of cholinesterase, detector kit using stabilized cholinesterase, and methods of making and using the same
US4357142A (en) * 1980-07-18 1982-11-02 Akzona Incorporated Glass support coated with synthetic polymer for bioprocess
US4456522A (en) * 1981-09-23 1984-06-26 Critikon, Inc. Support and anchoring mechanism for membranes in selectively responsive field effect devices
US4418148A (en) * 1981-11-05 1983-11-29 Miles Laboratories, Inc. Multilayer enzyme electrode membrane
US4415666A (en) * 1981-11-05 1983-11-15 Miles Laboratories, Inc. Enzyme electrode membrane
JPS5963554A (en) * 1982-10-04 1984-04-11 Hitachi Ltd Urease immobilizing urea electrode and its production
US4490216A (en) * 1983-02-03 1984-12-25 Molecular Devices Corporation Lipid membrane electroanalytical elements and method of analysis therewith
US4484987A (en) * 1983-05-19 1984-11-27 The Regents Of The University Of California Method and membrane applicable to implantable sensor
US4518527A (en) * 1983-08-16 1985-05-21 Mitsubishi Chemical Industries Limited Polypeptides related to the pre-acetylcholine receptor-α of the electric organ of Torpedo californica
IL69644A (en) * 1983-09-02 1986-11-30 Univ Ramot Enzyme electrodes and their preparation
US4592894A (en) * 1983-11-22 1986-06-03 The United States Of America As Represented By The United States Department Of Energy Field emission chemical sensor for receptor/binder, such as antigen/antibody
US4661235A (en) * 1984-08-03 1987-04-28 Krull Ulrich J Chemo-receptive lipid based membrane transducers
US4721601A (en) * 1984-11-23 1988-01-26 Massachusetts Institute Of Technology Molecule-based microelectronic devices
USH201H (en) * 1985-08-23 1987-01-06 United States Of America Biosensors from membrane proteins reconstituted in polymerized lipid bilayers
US4637861A (en) * 1985-12-16 1987-01-20 Allied Corporation Stabilized, lipid membrane-based device and method of analysis
JPH0721478B2 (en) * 1986-03-31 1995-03-08 財団法人化学及血清療法研究所 Working film for immunosensor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1318815A (en) * 1970-06-08 1973-05-31 Miles Lab Specific chemical probes
GB2136130A (en) * 1983-02-28 1984-09-12 Theodore Henry Krueger Chemical Assay Systems
WO1984003945A1 (en) * 1983-03-26 1984-10-11 Cambridge Life Sciences Conductimetric bioassay techniques
WO1987003095A1 (en) * 1985-11-19 1987-05-21 The Johns Hopkins University/Applied Physics Labor Capacitive sensor for chemical analysis and measurement

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts, vol. 107, no. 21, 23 November 1987 (Columbus, Ohio, US) Masao Gotoh et al.: "Acetylcholine sensor based on ion sensitive field effect transistor and acetylcholine receptor" *
Chemical Abstracts, vol. 88, no. 19, 8 May 1978 (Columbus, Ohio, US) Tran Minh Canh et al.: "Construction and study of an electrode using immobilized acetyl-cholinesterase for the determination of acetylcholine", see page 209 *

Also Published As

Publication number Publication date
US5001048A (en) 1991-03-19
JPH02503826A (en) 1990-11-08
EP0367788A1 (en) 1990-05-16
WO1988009808A2 (en) 1988-12-15

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