WO1988000027A1 - Method for treatment of morbid obesity - Google Patents

Method for treatment of morbid obesity Download PDF

Info

Publication number
WO1988000027A1
WO1988000027A1 PCT/US1986/001466 US8601466W WO8800027A1 WO 1988000027 A1 WO1988000027 A1 WO 1988000027A1 US 8601466 W US8601466 W US 8601466W WO 8800027 A1 WO8800027 A1 WO 8800027A1
Authority
WO
WIPO (PCT)
Prior art keywords
stomach
appliance
shape
esophagus
fundus
Prior art date
Application number
PCT/US1986/001466
Other languages
French (fr)
Inventor
Jean Pierre Angelchik
Original Assignee
Angelchik Jean P
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US06/690,852 priority Critical patent/US4607618A/en
Application filed by Angelchik Jean P filed Critical Angelchik Jean P
Priority to PCT/US1986/001466 priority patent/WO1988000027A1/en
Publication of WO1988000027A1 publication Critical patent/WO1988000027A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
    • A61F5/0003—Apparatus for the treatment of obesity; Anti-eating devices
    • A61F5/0013—Implantable devices or invasive measures
    • A61F5/0036—Intragastrical devices

Definitions

  • This invention pertains to medical treatment methods and apparatus useful therein. 5
  • the invention conce ⁇ a method for treating morbid obesity.
  • the invention 10 concerns an appliance useful in such treatment.
  • the invention relates to bougie, adapted for inserting the appliance into the fundus of the stomach.
  • treatment methods have been propos 25 wherein the interior volume of the stomach, is only temporar reduced by causing the patient to swallow an inflatable balloon which is inflated after it reaches the stomach.
  • the inflated balloon serves to substantially reduce the interior volume of the stomach such 30 that ingestion of a relatively small amount of food will cau distension of the stomach.
  • Such distension causes excitatio of certain neuroreceptors in the sub-mucosa of the stomach * ⁇ lying in the upper fundus.
  • Excitation of these neurorecep ⁇ tors which are endings of the vagus nerves of the gastric ⁇ 35 plexus, causes the patient to experience the sensation of satiety even though the patient has ingested only a rela ⁇ tively small amount of food.
  • Yet another object of the present invention is to provide apparatus for conveniently inserting appliances useful in such treatment methods.
  • Still another object of the invention is to provide such methods and apparatus which function more reliably and with a minimum of opportunity for undesired side effects.
  • Fig. 1 is a perspective view of a collapsible appliance which is useful in accordance with the method of the invention, shown in its normal uncollapsed shape;
  • Fig. 2 is a perspective view of the appliance of fig. 1 in the collapsed shape
  • Fig. 3 is a partially cut-away view of a bougie- type device for inserting the appliance of Figs. 1-2 into 5 the stomach;
  • Figs. 4A and 4B are sectional views of the stomach and esophagus illustrating insertion and final placement of the device of Figs. 1-2 into the fundus of the stomach 10 utilizing the bougie of Fig. 3;
  • Figs. 5 and 6 are partially cut-away perspective views of appliances constructed in accordance with alternat embodiments of the invention.
  • Tfee appliance comprises semi-rigid skeleto members joined to form a collapsible, hollow structure whic
  • the structure is temporarily deformable by external force to a collapsed sha and cross-section, such that it is dimensionally compatible
  • the bougie comprises a hollow, generally
  • -" ⁇ cylindrical, flexible barrel portion having an open lower end.
  • the barrel portion is cross-sectionally dimensioned t -, be inserted through the esophagus and the lower end thereof is dimensioned to receive and enclose the appliance and is adapted to exert and maintain inwardly directed circumferen force to maintain the appliance in the collapsed shape whil -4-
  • a collapsed c rounded portion of the appliance protrudes from the lower open end of the bougie and acts as an obturator.
  • Means are provided for ejecting the appliance from the lower end of the barrel portion into the fundus of the stomach.
  • I provide a method for treating morbid obesity which is an improvement upon the prior method involving implacement of a shaped device in the stomach to reduce the interior volume thereof.
  • the improvement comprises implacing , ,- a shaped structure which is normally shaped and dimensioned to be received and retained within the fundus portion of the stomach and which has a deformable semi-rigid skeletal struc ⁇ ture.
  • the implacement of the collapsible structure is accomplished by collapsing the semi-rigid skeleton thereof by applying external force to deform the structure to a shape and cross-sectional dimension which is insertable through the esophagus and cardiac opening, per-orally inserting the collapsed structure into the fundus and releasing the col ⁇ lapsing force to cause the collapsed structure to autogenously re-assume its normal uncollapsed shape.
  • Fig. 1 illustrates the presently preferred embodiment of an appliance constructed in accordance with the invention.
  • the 30 appliance generally indicated by reference numeral 10, simply consists of a plurality of normally semi-circular longitudinal skeleton members 11 joined at respective common ends 12 and 13 to form a collapsible hollow structure. As illustrated in
  • the force F (Fig. 2) can be applied and maintained in any convenient fashion, for example, by deforming the 5appliance by hand pressure and securing the appliance in the collapsed condition by tying dissolvable sutures around the circumference of the collapsed appliance at one or more points, as indicated by the dashed lines 14.
  • the device of Fig. 1 can be deforme by hand pressure and inserted into the lower end portion 15 of a bougie-type device (generally indicated by reference numeral 16), as shown in Fig. 3.
  • the appliance 10 in the collapsed condition as shown in Fig. 2 is enclosed by the wall 17 of the bougie 16 which exerts inwardly directed circumferential force to maintain the appliance 10 in the collapsed condition shown in Fig. 1.
  • the collapsed, rounded lower end 10a of the appliance 10 protrudes from the bougie acting as an obturator.
  • the bougie device 16 also includes a suitable ejector rod 18, operable through the upper end 19 of the bougie.
  • Movement of the rod 18 in the direction of the arrow A exerts force on an internal piston portion 20 formed on the lower end of the rod 18 which, in turn, exerts force upon the collapsed appliance 10, causing it to be ejec from the bougie 16 through the open lower end 21 thereof.
  • the bougie 16 is per-orally inserted through the esophagus 22 and the cardiac opening 23 of the stomach (generally indicated by reference character 24 Movement of the ejector rod 18 causes the collapsed appliance 10 to be displaced from the lower end 15 of the bougie 16 in the fundus 25 of the stomach 24.
  • the appliance 10 after it is completely ejected from the lower end of the bougie, auto ⁇ genously re-assumes its normal shape as shown in Fig. 1 and is received and retained within and substantially occupies the interior volume of the fundus 25, thereby reducing the -6-
  • FIG. 5 Alternative embodiments of the appliance of Fig. 1 are illustrated in Figs. 5 and 6.
  • a flexible integument 26 either attached to the inside surfaces of the skeleton members 11 (as shown in Fig. 5) or to their outer surfaces (as shown in Fig. 6) .
  • the integument 26 is pleated and folded into the interior of the appliance 10 so as not to interfere with the insertion of the applicance in the bougie or its ejection therefrom into the fundus. The integument will prevent the formation of a bezoar in the interior of the appliance 10.
  • the appliance can be constructed of lightweight or hollow materials which will float in the liquids within the stomach.
  • the materials of construction of the appliance are not highly critical so long as they are compatible with the body tissues and fluids involved.
  • Removal of the appliance can be effected by various means including surgical invasion or retrieval through the esophagus by endoscopic techniques. In certain applications, it may be desirable to form the entire appliance of biodegrada materials such that the device will dissolve after a pre-selec period of time in the stomach and be passed from the body through the digestive tract.

Abstract

Morbid obesity is treated by implacement in the fundus of a hollow shaped appliance. The appliance (10) is formed of semi-rigid skeleton members (11) and is collapsible to a dimension and shape which can be inserted into the stomach through the esophagus and cardiac opening. Upon release of the collapsed device in the stomach, it autogenously re-assumes its normal uncollapsed shape.

Description

-1- .
1 METHOD FOR TREATMENT OF MORBID OBESITY
This invention pertains to medical treatment methods and apparatus useful therein. 5
In a more particular respect, the invention conce ~ a method for treating morbid obesity.
In another particular respect, the invention 10 concerns an appliance useful in such treatment.
In yet another respect, the invention relates to bougie, adapted for inserting the appliance into the fundus of the stomach.
15
In the past, treatment of morbid obesity has been attempted by a variety of medical techniques, including, for example, removal of portions of the stomach and/or intestines, and stapling the stomach to reduce its volume.
20 Such treatments either reduce the volume of food which can be comfortably ingested or the efficiency with which it is digested.
More recently, treatment methods have been propos 25 wherein the interior volume of the stomach, is only temporar reduced by causing the patient to swallow an inflatable balloon which is inflated after it reaches the stomach. According to this method, the inflated balloon serves to substantially reduce the interior volume of the stomach such 30 that ingestion of a relatively small amount of food will cau distension of the stomach. Such distension causes excitatio of certain neuroreceptors in the sub-mucosa of the stomach *^ lying in the upper fundus. Excitation of these neurorecep¬ tors, which are endings of the vagus nerves of the gastric ι 35 plexus, causes the patient to experience the sensation of satiety even though the patient has ingested only a rela¬ tively small amount of food. -2-
While such techniques have met with certain success they do suffer certain disadvantages, principally associated with the mechanical integrity of the balloon, inflation of the balloon and the need to remove the balloon periodically or after the treatment period.
It would be highly advantageous to provide medical methods for treatment of morbid obesity which simplify the insertion and removal of volume-reduction devices into and from the stomach and which more reliably provide the neces¬ sary volume reduction while minimizing untoward side effects caused by displacement of the devices within the stomach, accidental deflation, and the like.
It is, therefore, the principal object of the present invention to provide improved methods and apparatus for treatment of morbid obesity.
Yet another object of the present invention is to provide apparatus for conveniently inserting appliances useful in such treatment methods.
Still another object of the invention is to provide such methods and apparatus which function more reliably and with a minimum of opportunity for undesired side effects.
These and other, further and more specific objects and advantages of the invention will be apparent to those skilled in the art from the following detailed description thereof, taken in conjunction with the drawings, in which:
Fig. 1 is a perspective view of a collapsible appliance which is useful in accordance with the method of the invention, shown in its normal uncollapsed shape;
Fig. 2 is a perspective view of the appliance of fig. 1 in the collapsed shape;
Figure imgf000005_0001
1 -3-
Fig. 3 is a partially cut-away view of a bougie- type device for inserting the appliance of Figs. 1-2 into 5 the stomach;
Figs. 4A and 4B are sectional views of the stomac and esophagus illustrating insertion and final placement of the device of Figs. 1-2 into the fundus of the stomach 10 utilizing the bougie of Fig. 3;
Figs. 5 and 6 are partially cut-away perspective views of appliances constructed in accordance with alternat embodiments of the invention.
15
Brieflye in accordance with the present invention
I provide an intra-gastric appliance for the treatment of morbid obesity. Tfee appliance comprises semi-rigid skeleto members joined to form a collapsible, hollow structure whic
20 s dimensioned and saormally shaped to be received and retained within the fandus portion of the stomach. To facilitate implaceβent of the appliance, the structure is temporarily deformable by external force to a collapsed sha and cross-section, such that it is dimensionally compatible
25 with per-oral implacement of ithe appliance through the esophagus and cardiac opening of the stomach. Upon release of the collapsing force, t s appliance autogenously re-assu its normal uncollapsed shape-
30 In accordance wi±Ja another aspect of the inventio I provide a bougie for per-oral implacement of the applianc described above. The bougie comprises a hollow, generally
-"\ cylindrical, flexible barrel portion having an open lower end. The barrel portion is cross-sectionally dimensioned t -, be inserted through the esophagus and the lower end thereof is dimensioned to receive and enclose the appliance and is adapted to exert and maintain inwardly directed circumferen force to maintain the appliance in the collapsed shape whil -4-
it is received in the lower end of the bougie. A collapsed c rounded portion of the appliance protrudes from the lower open end of the bougie and acts as an obturator. Means are provided for ejecting the appliance from the lower end of the barrel portion into the fundus of the stomach.
0 In accordance with yet another aspect of the invention, I provide a method for treating morbid obesity which is an improvement upon the prior method involving implacement of a shaped device in the stomach to reduce the interior volume thereof. The improvement comprises implacing , ,- a shaped structure which is normally shaped and dimensioned to be received and retained within the fundus portion of the stomach and which has a deformable semi-rigid skeletal struc¬ ture. The implacement of the collapsible structure is accomplished by collapsing the semi-rigid skeleton thereof by applying external force to deform the structure to a shape and cross-sectional dimension which is insertable through the esophagus and cardiac opening, per-orally inserting the collapsed structure into the fundus and releasing the col¬ lapsing force to cause the collapsed structure to autogenously re-assume its normal uncollapsed shape.
Turning now to the drawings, in which like reference characters identify the same elements in the several views,
Fig. 1 illustrates the presently preferred embodiment of an appliance constructed in accordance with the invention. The 30 appliance, generally indicated by reference numeral 10, simply consists of a plurality of normally semi-circular longitudinal skeleton members 11 joined at respective common ends 12 and 13 to form a collapsible hollow structure. As illustrated in
Fig. 2, application of inwardly directed force F causes temporary deformation of the appliance from the spherical shape as shown in Fig. 1 to the elongate shape of reduced cross-section as shown in Fig. 2. 1 -5-
The force F (Fig. 2) can be applied and maintained in any convenient fashion, for example, by deforming the 5appliance by hand pressure and securing the appliance in the collapsed condition by tying dissolvable sutures around the circumference of the collapsed appliance at one or more points, as indicated by the dashed lines 14.
Alternatively, the device of Fig. 1 can be deforme by hand pressure and inserted into the lower end portion 15 of a bougie-type device (generally indicated by reference numeral 16), as shown in Fig. 3. The appliance 10, in the collapsed condition as shown in Fig. 2, is enclosed by the wall 17 of the bougie 16 which exerts inwardly directed circumferential force to maintain the appliance 10 in the collapsed condition shown in Fig. 1. The collapsed, rounded lower end 10a of the appliance 10 protrudes from the bougie acting as an obturator. The bougie device 16 also includes a suitable ejector rod 18, operable through the upper end 19 of the bougie. Movement of the rod 18 in the direction of the arrow A exerts force on an internal piston portion 20 formed on the lower end of the rod 18 which, in turn, exerts force upon the collapsed appliance 10, causing it to be ejec from the bougie 16 through the open lower end 21 thereof.
As shown in Fig. 4A, the bougie 16 is per-orally inserted through the esophagus 22 and the cardiac opening 23 of the stomach (generally indicated by reference character 24 Movement of the ejector rod 18 causes the collapsed appliance 10 to be displaced from the lower end 15 of the bougie 16 in the fundus 25 of the stomach 24.
As shown in Fig. 4B, the appliance 10, after it is completely ejected from the lower end of the bougie, auto¬ genously re-assumes its normal shape as shown in Fig. 1 and is received and retained within and substantially occupies the interior volume of the fundus 25, thereby reducing the -6-
total interior volume of the stomach by upwards of 30%-50%.
Alternative embodiments of the appliance of Fig. 1 are illustrated in Figs. 5 and 6.
In certain instances, as where the appliance is intended to remain in the stomach for extended periods of time, it may be desirable to enclose the hollow structure by means of a flexible integument 26, either attached to the inside surfaces of the skeleton members 11 (as shown in Fig. 5) or to their outer surfaces (as shown in Fig. 6) . During insertion, the integument 26 is pleated and folded into the interior of the appliance 10 so as not to interfere with the insertion of the applicance in the bougie or its ejection therefrom into the fundus. The integument will prevent the formation of a bezoar in the interior of the appliance 10.
In order to enhance and maintain the accuracy of placement of the appliance in the stomach, the appliance can be constructed of lightweight or hollow materials which will float in the liquids within the stomach. The materials of construction of the appliance are not highly critical so long as they are compatible with the body tissues and fluids involved.
Removal of the appliance can be effected by various means including surgical invasion or retrieval through the esophagus by endoscopic techniques. In certain applications, it may be desirable to form the entire appliance of biodegrada materials such that the device will dissolve after a pre-selec period of time in the stomach and be passed from the body through the digestive tract.
Having described my invention in such terms as to enable those skilled in the art to understand and practice it, and having identified the presently preferred embodiments ther

Claims

1 -7-Claims
1. In a method for treating morbid obesity, including the step of implacing a shaped device in the stomach, the 5 improvement comprising:
(a) providing a collapsible, hollow, shaped device, said device
10 (i) being normally shaped and dimensioned to be received and retained within the fundus without deforming the stomach walls beyond its normal shape and dimensions,
15
(ii) being formed of a semi-rigid skeleton which is collapsible by the application of external force to deform said device to a shape and cross-sectional dimension
20 which is insertable into the stomach through the esophagus and the cardiac opening,
(iii) being capable of autogenously reassuming 25 and retaining said normal shape when such collapsing external force is removed;
(b) collapsing said semi-rigid skeleton device by applying such external force to said shape and
30 cross-sectional dimensions for insertion through the esophagus and cardiac opening;
(c) per-orally inserting said collapsed structure s*\ into the fundus of the stomach through the
35 esophagus and cardiac opening;
(d) releasing said collapsing force to cause said collapsed skeleton structure to autogenously reassume and retain its normal shape; and (e) maintaining said device within the stomach for a length of time sufficient to cause a substantial weight loss by the patient.
PCT/US1986/001466 1983-02-23 1986-07-09 Method for treatment of morbid obesity WO1988000027A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US06/690,852 US4607618A (en) 1983-02-23 1985-01-11 Method for treatment of morbid obesity
PCT/US1986/001466 WO1988000027A1 (en) 1986-07-09 1986-07-09 Method for treatment of morbid obesity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1986/001466 WO1988000027A1 (en) 1986-07-09 1986-07-09 Method for treatment of morbid obesity

Publications (1)

Publication Number Publication Date
WO1988000027A1 true WO1988000027A1 (en) 1988-01-14

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Application Number Title Priority Date Filing Date
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Country Status (1)

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WO (1) WO1988000027A1 (en)

Cited By (33)

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Publication number Priority date Publication date Assignee Title
US5467633A (en) * 1993-08-25 1995-11-21 Sankyo Seisakusho Co. Mechanical pressing machine
EP1401320A2 (en) * 2000-11-03 2004-03-31 Satiety, Inc. Method and device for use in minimally invasive placement of intragastric devices
WO2005107641A2 (en) 2004-05-03 2005-11-17 Fulfillium, Inc. Method and system for gastric volume control
WO2006055839A2 (en) 2004-11-19 2006-05-26 Fulfillium, Inc. Wireless breach detection
WO2007027812A2 (en) 2005-08-29 2007-03-08 Baronova, Inc. Gastric retaining devices and methods
WO2007075978A3 (en) * 2005-12-22 2007-11-29 Wilson Cook Medical Inc Coiled intragastric member for treating obesity
WO2012097225A2 (en) 2011-01-13 2012-07-19 Sensurtec, Inc. Breach detection in solid structures
WO2012054297A3 (en) * 2010-10-19 2012-08-02 Allergan, Inc. Intragastric implants with collapsible frames
EP2579936A1 (en) * 2010-06-13 2013-04-17 Virender K. Sharma Intragastric device for treating obesity
US8870966B2 (en) 2010-10-18 2014-10-28 Apollo Endosurgery, Inc. Intragastric balloon for treating obesity
US8920447B2 (en) 2010-10-19 2014-12-30 Apollo Endosurgery, Inc. Articulated gastric implant clip
US8956380B2 (en) 2010-10-18 2015-02-17 Apollo Endosurgery, Inc. Reactive intragastric implant devices
US9072579B2 (en) 2009-10-21 2015-07-07 Apollo Endosurgery, Inc. Bariatric device and method for weight loss
US9095405B2 (en) 2010-10-19 2015-08-04 Apollo Endosurgery, Inc. Space-filling intragastric implants with fluid flow
US9155650B2 (en) 2010-03-15 2015-10-13 Apollo Endosurgery, Inc. Bariatric device and method for weight loss
US9198790B2 (en) 2010-10-19 2015-12-01 Apollo Endosurgery, Inc. Upper stomach gastric implants
US9233016B2 (en) 2010-10-18 2016-01-12 Apollo Endosurgery, Inc. Elevating stomach stimulation device
US9398969B2 (en) 2010-10-19 2016-07-26 Apollo Endosurgery, Inc. Upper stomach gastric implants
US9456915B2 (en) 2004-11-19 2016-10-04 Fulfilium, Inc. Methods, devices, and systems for obesity treatment
US9463107B2 (en) 2010-10-18 2016-10-11 Apollo Endosurgery, Inc. Variable size intragastric implant devices
US9498365B2 (en) 2010-10-19 2016-11-22 Apollo Endosurgery, Inc. Intragastric implants with multiple fluid chambers
US9498366B2 (en) 2003-07-28 2016-11-22 Baronova, Inc. Devices and methods for pyloric anchoring
US9504591B2 (en) 2007-09-07 2016-11-29 Baronova, Inc. Device for intermittently obstructing a gastric opening and method of use
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
US9668901B2 (en) 2010-10-18 2017-06-06 Apollo Endosurgery Us, Inc. Intragastric implants with duodenal anchors
US9700450B2 (en) 2003-07-28 2017-07-11 Baronova, Inc. Devices and methods for gastrointestinal stimulation
US10070981B2 (en) 2013-03-15 2018-09-11 Baronova, Inc. Locking gastric obstruction device and method of use
US10070980B2 (en) 2010-10-19 2018-09-11 Apollo Endosurgery Us, Inc. Anchored non-piercing duodenal sleeve and delivery systems
US10413436B2 (en) 2010-06-13 2019-09-17 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
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US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
US11135078B2 (en) 2010-06-13 2021-10-05 Synerz Medical, Inc. Intragastric device for treating obesity

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Publication number Priority date Publication date Assignee Title
US5467633A (en) * 1993-08-25 1995-11-21 Sankyo Seisakusho Co. Mechanical pressing machine
EP1401320A4 (en) * 2000-11-03 2008-09-17 Satiety Inc Method and device for use in minimally invasive placement of intragastric devices
EP1401320A2 (en) * 2000-11-03 2004-03-31 Satiety, Inc. Method and device for use in minimally invasive placement of intragastric devices
US7753928B2 (en) 2000-11-03 2010-07-13 Satiety, Inc. Method and device for use in minimally invasive placement of intragastric devices
US9498366B2 (en) 2003-07-28 2016-11-22 Baronova, Inc. Devices and methods for pyloric anchoring
US9642735B2 (en) 2003-07-28 2017-05-09 Baronova, Inc. Pyloric valve corking device
US9510834B2 (en) 2003-07-28 2016-12-06 Baronova, Inc. Gastric retaining devices and methods
US9687243B2 (en) 2003-07-28 2017-06-27 Baronova, Inc. Gastric retaining devices and methods
US9700450B2 (en) 2003-07-28 2017-07-11 Baronova, Inc. Devices and methods for gastrointestinal stimulation
US11197774B2 (en) 2003-07-28 2021-12-14 Baronova, Inc. Devices and methods for gastrointestinal stimulation
US9924948B2 (en) 2003-07-28 2018-03-27 Baronova, Inc. Gastric retaining devices and methods
US9931122B2 (en) 2003-07-28 2018-04-03 Baronova, Inc. Gastric retaining devices and methods
WO2005107641A2 (en) 2004-05-03 2005-11-17 Fulfillium, Inc. Method and system for gastric volume control
US8066780B2 (en) 2004-05-03 2011-11-29 Fulfillium, Inc. Methods for gastric volume control
US10179060B2 (en) 2004-11-19 2019-01-15 Fulfillium, Inc. Methods, devices, and systems for obesity treatment
US9445930B2 (en) 2004-11-19 2016-09-20 Fulfillium, Inc. Methods, devices, and systems for obesity treatment
US10524946B2 (en) 2004-11-19 2020-01-07 Fulfillium, Inc. Methods, devices, and systems for obesity treatment
WO2006055839A2 (en) 2004-11-19 2006-05-26 Fulfillium, Inc. Wireless breach detection
US10285835B2 (en) 2004-11-19 2019-05-14 Fulfillium, Inc. Methods, devices, and systems for obesity treatment
US11026825B2 (en) 2004-11-19 2021-06-08 Fulfillium, Inc. Methods, devices, and systems for obesity treatment
US9456915B2 (en) 2004-11-19 2016-10-04 Fulfilium, Inc. Methods, devices, and systems for obesity treatment
US9808367B2 (en) 2004-11-19 2017-11-07 Fulfillium, Inc. Methods, devices, and systems for obesity treatment
US8070807B2 (en) 2004-11-19 2011-12-06 Fulfillium, Inc. Wireless breach detection
WO2007027812A2 (en) 2005-08-29 2007-03-08 Baronova, Inc. Gastric retaining devices and methods
EP1919370A4 (en) * 2005-08-29 2015-07-29 Baronova Inc Gastric retaining devices and methods
WO2007075978A3 (en) * 2005-12-22 2007-11-29 Wilson Cook Medical Inc Coiled intragastric member for treating obesity
JP2009521277A (en) * 2005-12-22 2009-06-04 ウィルソン−クック・メディカル・インコーポレーテッド Coil-like intragastric member for the treatment of obesity
US10736763B2 (en) 2007-09-07 2020-08-11 Baronova, Inc. Device for intermittently obstructing a gastric opening
US9504591B2 (en) 2007-09-07 2016-11-29 Baronova, Inc. Device for intermittently obstructing a gastric opening and method of use
US10166133B2 (en) 2007-09-07 2019-01-01 Baronova, Inc. Device for intermittently obstructing a gastric opening
US9072579B2 (en) 2009-10-21 2015-07-07 Apollo Endosurgery, Inc. Bariatric device and method for weight loss
US9532892B2 (en) 2009-10-21 2017-01-03 Apollo Endosurgery, Inc. Bariatric device and method for weight loss
US10111771B2 (en) 2009-10-21 2018-10-30 Apollo Endosurgery Us, Inc. Bariatric device and method for weight loss
US9155650B2 (en) 2010-03-15 2015-10-13 Apollo Endosurgery, Inc. Bariatric device and method for weight loss
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
EP2579936A1 (en) * 2010-06-13 2013-04-17 Virender K. Sharma Intragastric device for treating obesity
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