WO1987005198A1 - Blood sampling device - Google Patents

Blood sampling device Download PDF

Info

Publication number
WO1987005198A1
WO1987005198A1 PCT/DE1987/000092 DE8700092W WO8705198A1 WO 1987005198 A1 WO1987005198 A1 WO 1987005198A1 DE 8700092 W DE8700092 W DE 8700092W WO 8705198 A1 WO8705198 A1 WO 8705198A1
Authority
WO
WIPO (PCT)
Prior art keywords
tube
piston
blood
piston rod
handle
Prior art date
Application number
PCT/DE1987/000092
Other languages
German (de)
French (fr)
Inventor
Uwe Ballies
Original Assignee
Uwe Ballies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uwe Ballies filed Critical Uwe Ballies
Publication of WO1987005198A1 publication Critical patent/WO1987005198A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/15003—Source of blood for venous or arterial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150236—Pistons, i.e. cylindrical bodies that sit inside the syringe barrel, typically with an air tight seal, and slide in the barrel to create a vacuum or to expel blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150244—Rods for actuating or driving the piston, i.e. the cylindrical body that sits inside the syringe barrel, typically with an air tight seal, and slides in the barrel to create a vacuum or to expel blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150259—Improved gripping, e.g. with high friction pattern or projections on the housing surface or an ergonometric shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150351—Caps, stoppers or lids for sealing or closing a blood collection vessel or container, e.g. a test-tube or syringe barrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150885—Preventing re-use
    • A61B5/150908—Preventing re-use by disconnecting components, e.g. breaking or rupturing of connected parts, e.g. piston and rod

Definitions

  • the invention relates to a blood sampling device with a tube, a device arranged at the bottom of the tube for introducing the blood, a piston inserted into the tube and a piston rod for moving the piston in the tube.
  • the piston rod is connected directly to the piston via a predetermined breaking point, the piston rod being broken off after the blood has been drawn into the tube and the piston remaining in the tube, closing the upper end thereof. Access to the withdrawn blood is then made possible by unscrewing a cap which closes the bottom of the tube and which accommodates the cannula socket which forms the device for introducing the blood. The cap closing the bottom of the tube is then unscrewed again for analyzing the withdrawn blood.
  • the known blood collection device has the disadvantage that during manufacture the cap closing the bottom of the tube is shaped separately, screwed onto the tube and used to analyze the blood must be unscrewed again.
  • the invention has for its object to improve the blood collection device of the type mentioned in such a way that the manufacture and use is simplified.
  • this object is achieved in that a handle piece is arranged between the piston and the piston rod, which is fixed to the piston and connected to the piston rod via a predetermined breaking point.
  • a particularly preferred embodiment is characterized by a stopper formed on the inner wall of the tube in the vicinity of its upper edge.
  • This stopper is preferably formed as a thread, the piston being provided with knobs or the like which engage in the thread.
  • the handle is tongue-shaped and is provided with corrugation.
  • the handle can also be pear-shaped.
  • Fig. 1 is a sectional view of the device before taking blood
  • Fig. 2 is a sectional view of the device after blood sampling.
  • the blood collection device consists of a tube 10, a cannula nozzle attached to its base 12
  • a piston 16 arranged displaceably in the tube, a handle 22 connected to the piston 16 and connected to a piston rod 18 via a predetermined breaking point 20.
  • a cannula (not shown) is attached to the cannula nozzle 14 and, after being inserted into the vein, the blood is drawn into the tube by pulling the piston rod 18; After the knobs 30 of the piston 16 abut against the thread 28 formed in the vicinity of the upper edge 26 of the tube ⁇ 10, the piston rod 18 is broken off above the handle piece 22 at the predetermined breaking point 20. The handle 22 now protrudes beyond the edge 26 of the tube 10 and is therefore accessible. After removing the piston rod 18, the piston 16 now forms a stopper which reliably closes the tube.
  • the grip between the thumb and forefinger is grasped and rotated counter-clockwise relative to the tube 10.
  • the knobs engage in the thread 28, which causes an axial displacement of the piston in the tube when further turning.
  • the piston is pushed axially out of the tube.
  • the piston 16 can be pulled off slightly upwards, since the sealing lips 32 arranged at the lower end of the piston - unlike the knobs 30 - are flexible.
  • the proposed device can also be used with cannulas in which the device for introducing the blood is not formed by a cannula nozzle but by a membrane to be pierced by a cannula.
  • the knobs 30 or the like on the piston 16 can be wedge-shaped with a downward slope so that the piston can be inserted into the tube without a turning operation. However, it is also possible to stamp the thread 28 on the tube only after it has been inserted into the tube.

Abstract

A blood sampling device includes a tubule (10), an element arranged at the bottom (12) of the tubule (10) for introducing blood in the tubule, a piston (16) displaceable in the tubule (10) and a piston rod (18) for moving the piston (16) and linked to the piston rod (18) by a predetermined breaking point (20).

Description

BlutentnahmeVorrichtung Blood sampling device
Die Erfindung betrifft eine Blutentnahmevorrichtung mit einem Röhrchen, einer an den Boden des Röhrchens ange¬ ordneten Einrichtung zum Einbringen des Blutes, einem in dem Röhrchen eingeführten Kolben und einer Kolben¬ stange zum Bewegen des Kolbens in dem Röhrchen.The invention relates to a blood sampling device with a tube, a device arranged at the bottom of the tube for introducing the blood, a piston inserted into the tube and a piston rod for moving the piston in the tube.
Bei einer vorbekannten derartigen Blutentnahmevorrich¬ tung ist die Kolbenstange über eine Sollbruchstelle direkt mit dem Kolben verbunden, wobei die Kolbenstange nach Aufziehen des Blutes in das Röhrchen abgebrochen wird und der Kolben das obere Ende des Röhrchens ver¬ schließend in diesem verbleibt. Der Zugang zu dem ent¬ nommenen Blut wird sodann durch Abschrauben einer den Boden des Röhrchens verschließenden, den die Einrich¬ tung zum Einbringen des Blutes bildenden Kanülenstutzen aufnehmenden Kappe ermöglicht. Zum Analysieren des entnommenen Blutes wird sodann die den Boden des Röhr¬ chens verschließende Kappe wieder abgeschraubt.In a previously known blood sampling device of this type, the piston rod is connected directly to the piston via a predetermined breaking point, the piston rod being broken off after the blood has been drawn into the tube and the piston remaining in the tube, closing the upper end thereof. Access to the withdrawn blood is then made possible by unscrewing a cap which closes the bottom of the tube and which accommodates the cannula socket which forms the device for introducing the blood. The cap closing the bottom of the tube is then unscrewed again for analyzing the withdrawn blood.
Die bekannte Blutentnahmevorrichtung hat den Nachteil, daß bei der Herstellung die den Boden des Röhrchens verschließende Kappe gesondert ausgeformt, auf das Röhrchen aufgeschraubt und zum Analysieren des aufge- nommenen Blutes wieder abgeschraubt werden muß.The known blood collection device has the disadvantage that during manufacture the cap closing the bottom of the tube is shaped separately, screwed onto the tube and used to analyze the blood must be unscrewed again.
Der Erfindung liegt die Aufgabe zugrunde, die Blutent¬ nahmevorrichtung der eingangs genannten Art dahingehend zu verbessern, daß die Herstellung und Benutzung ver¬ einfacht wird.The invention has for its object to improve the blood collection device of the type mentioned in such a way that the manufacture and use is simplified.
Erfindungsgemäß wird diese Aufgabe dadurch gelöst, daß ein zwischen Kolben und Kolbenstange angeordnetes, mit dem Kolben fest und mit der Kolbenstange über eine Sollbruchstelle verbundenes Griffstück vorgesehen ist.According to the invention, this object is achieved in that a handle piece is arranged between the piston and the piston rod, which is fixed to the piston and connected to the piston rod via a predetermined breaking point.
Eine besonders bevorzugte Ausführungsform zeichnet sich aus durch einen an der Innenwandung des Rδhrchens in der Nähe dessen oberen Randes ausgebildeten Stopper. Dieser Stopper ist vorzugsweise als Gewindegang ausge¬ bildet, wobei der Kolben mit Noppen oder dergleichen versehen ist, die in den Gewindegang eingreifen.A particularly preferred embodiment is characterized by a stopper formed on the inner wall of the tube in the vicinity of its upper edge. This stopper is preferably formed as a thread, the piston being provided with knobs or the like which engage in the thread.
Vorzugsweise ist vorgesehen, daß das Griffstück zungen- för ig ausgebildet und mit einer Riffelung versehen ist. Das Griffstück kann aber auch birnenförmig ausge¬ bildet sein.It is preferably provided that the handle is tongue-shaped and is provided with corrugation. The handle can also be pear-shaped.
Weitere Merkmale und Vorteile der Erfindung ergeben sich aus der Beschreibung, in der ein Ausführungsbei¬ spiel der Erfindung anhand einer Zeichnung erläutert wird. Dabei zeigt:Further features and advantages of the invention result from the description in which an exemplary embodiment of the invention is explained with reference to a drawing. It shows:
Fig. 1 eine Schnittdarstellung der Vorrichtung vor der Blutentnahme, undFig. 1 is a sectional view of the device before taking blood, and
Fig. 2 eine Schnittdarstellung der Vorrichtung nach der Blutentnahme.Fig. 2 is a sectional view of the device after blood sampling.
ie Blutentnahmevorrichtung besteht aus einem Röhrchen 10, einen an dessen Boden 12 angesetzten Kanülenstutzen
Figure imgf000005_0001
The blood collection device consists of a tube 10, a cannula nozzle attached to its base 12
Figure imgf000005_0001
33
14, einem in dem Röhrchen verschiebbar angeordneten Kolben 16, einem mit dem Kolben 16 fest und mit einer Kolbenstange 18 über eine Sollbruchstelle 20 verbunde¬ nen Griffstück 22.14, a piston 16 arranged displaceably in the tube, a handle 22 connected to the piston 16 and connected to a piston rod 18 via a predetermined breaking point 20.
Zur Verwendung dieser Blutentnahmevorrichtung wird eine - nicht gezeigte - Kanüle an den Kanülenstutzen 14 angesetzt und nach Einstechen in die Vene das Blut durch Aufziehen der Kolbenstange 18 in das Röhrchen eingesogen; Nach Anstoßen der Noppen 30 des Kolbens 16 gegen den in der Nähe des oberen Randes 26 des Röhr- chen≤ 10 ausgebildeten Gewindegangs 28 wird die Kolben¬ stange 18 oberhalb des Griff Stücks 22 an der Sollbruch¬ stelle 20 abgebrochen. Das Griffstück 22 ragt nun über den Rand 26 des Röhrchens 10 hinaus und ist damit zugänglich. Der Kolben 16 bildet jetzt nach Entfernen der Kolbenstange 18 einen Stöpsel, der das Röhrchen zuverlässig verschließt.To use this blood collection device, a cannula (not shown) is attached to the cannula nozzle 14 and, after being inserted into the vein, the blood is drawn into the tube by pulling the piston rod 18; After the knobs 30 of the piston 16 abut against the thread 28 formed in the vicinity of the upper edge 26 of the tube ≤ 10, the piston rod 18 is broken off above the handle piece 22 at the predetermined breaking point 20. The handle 22 now protrudes beyond the edge 26 of the tube 10 and is therefore accessible. After removing the piston rod 18, the piston 16 now forms a stopper which reliably closes the tube.
Um das von dem Röhrchen aufgenommene Blut nun für die Analyse zugänglich zu machen, wird das Griffstück zwi¬ schen Daumen und Zeigefinger erfaßt und gegen den Uhr¬ zeigersinn relativ zum Röhrchen 10 verdreht. Dabei greifen die Noppen in den Gewindegang 28 ein, was bei weiterem Verdrehen eine axiale Verschiebung des Kolbens in dem Röhrchen bewirkt. Bei weiterem Verdrehen des Griff Stücks 22 relativ zum Röhrchen 10 wird der Kolben so axial aus dem Röhrchen herausgeschoben. Nach Austre¬ ten der Noppen 30 aus dem Gewindegang 28 kann der Kolben 16 leicht nach oben abgezogen werden, da die am unteren Ende des Kolbens angeordneten Dichtlippen 32 - anders als die Noppen 30 - nachgiebig sind.In order to make the blood taken up by the tube accessible for analysis, the grip between the thumb and forefinger is grasped and rotated counter-clockwise relative to the tube 10. The knobs engage in the thread 28, which causes an axial displacement of the piston in the tube when further turning. When the handle piece 22 is further rotated relative to the tube 10, the piston is pushed axially out of the tube. After the knobs 30 have emerged from the thread 28, the piston 16 can be pulled off slightly upwards, since the sealing lips 32 arranged at the lower end of the piston - unlike the knobs 30 - are flexible.
Anders als bei der vorbekannten Blutentnahmevorrichtung wird also der Zugang zu dem entnommenen Blut nicht durch Abschrauben einer den Boden des Röhrchens bilden¬ den Kappe, sondern durch Abziehen bzw Herausschrauben des mit einem Griffstück versehenen, die Funktion eines Stöpsels übernehmenden Kolbens bewirkt.In contrast to the previously known blood collection device, access to the withdrawn blood is therefore not by unscrewing a cap forming the bottom of the tube, but by pulling it out or unscrewing it of the piston provided with a handle, which takes over the function of a stopper.
Es versteht sich, daß die vorgeschlagene Vorrichtung auch bei Kanülen verwendet werden kann, bei denen die Einrichtung zum Einbringen des Blutes nicht durch einen Kanülenstutzen sondern durch eine von einer Kanüle zu durchstechenden Membran gebildet wird.It goes without saying that the proposed device can also be used with cannulas in which the device for introducing the blood is not formed by a cannula nozzle but by a membrane to be pierced by a cannula.
Die Noppen 30 oder dergleichen- an dem Kolben 16 können keilförmig mit nach unten weisender Schräge ausgebildet sein, damit das Einsetzen des Kolbens in das Röhrchen ohne einen Drehvorgang möglich wird. Es ist jedoch auch möglich, den Gewindegang 28 erst nach Einsetzen des Kolbens in das Röhrchen auf dieses aufzuprägen. The knobs 30 or the like on the piston 16 can be wedge-shaped with a downward slope so that the piston can be inserted into the tube without a turning operation. However, it is also possible to stamp the thread 28 on the tube only after it has been inserted into the tube.

Claims

- ~ -Ansprüche - ~ claims
1. Blutennahmevorrichtung mit einem Röhrchen (10), einer an dem Boden (12) des Röhrchens (10) angeordneten Einrichtung zum Einbringen des Blutes in das Röhrchen, einem in dem Röhrchen (10) geführten Kolben (16) und einer Kolbenstange (18) zum Bewegen des Kolbens (16) in dem Röhrchen (10), dadurch gekennzeichnet, daß ein zwischen Kolben (16) und Kolbenstange (18) angeordne¬ tes, mit dem Kolben (16) fest und mit der Kolbenstange (18) über eine Sollbruchstelle (20) verbundenes Griff- stück (22) vorgesehen ist.1. Blood collection device with a tube (10), a device arranged on the bottom (12) of the tube (10) for introducing the blood into the tube, a piston (16) guided in the tube (10) and a piston rod (18) for moving the piston (16) in the tube (10), characterized in that an arrangement between the piston (16) and the piston rod (18) is fixed with the piston (16) and with the piston rod (18) via a predetermined breaking point (20) connected handle (22) is provided.
2. Blutentnahmevorrichtung nach Anspruch 1 , gekenn¬ zeichnet durch einen an der Innenwandung des Rδhrchens (10) in der Nähe dessen oberen Randes (26) ausgebilde¬ ten Stopper. - 2. Blood collection device according to claim 1, marked by a stopper on the inner wall of the tube (10) in the vicinity of its upper edge (26). -
3. Blutentnahmevorrichtung nach Anspruch 2, dadurch gekennzeichnet, daß der Stopper als Gewindegang (28) ausgebildet ist, wobei der Kolben (16) mit in den Gewindegang (28) eingreifenden Noppen (30) oder der¬ gleichen versehen ist.3. Blood sampling device according to claim 2, characterized in that the stopper is designed as a thread (28), the piston (16) having knobs (30) engaging in the thread (28) or the like being provided.
4. Blutentnahmevorrichtung nach einem der vorangehen¬ den Ansprüche, dadurch gekennzeichnet, daß das Griff¬ stück (22) zungenfδrmig ausgebildet und mit einer Rif- felung (24) versehen ist.4. Blood collection device according to one of the preceding claims, characterized in that the handle (22) is tongue-shaped and is provided with a corrugation (24).
5. Blutentnahmevorrichtung nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, daß das Griffstück bir¬ nenförmig ausgebildet ist. 5. Blood sampling device according to one of claims 1 to 3, characterized in that the handle is formed in a pear-shaped manner.
PCT/DE1987/000092 1986-03-04 1987-03-04 Blood sampling device WO1987005198A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEG8605803.7U 1986-03-04
DE8605803U DE8605803U1 (en) 1986-03-04 1986-03-04

Publications (1)

Publication Number Publication Date
WO1987005198A1 true WO1987005198A1 (en) 1987-09-11

Family

ID=6792329

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1987/000092 WO1987005198A1 (en) 1986-03-04 1987-03-04 Blood sampling device

Country Status (3)

Country Link
EP (1) EP0262165A1 (en)
DE (1) DE8605803U1 (en)
WO (1) WO1987005198A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0643944A1 (en) * 1993-09-22 1995-03-22 B. Braun Melsungen Ag Blood sampling device

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3747812A (en) * 1971-10-21 1973-07-24 Medical Concepts Inc Syringe
US3937211A (en) * 1972-10-27 1976-02-10 Fa. Walter Sarstedt Kunststoff-Spritzgusswerk Multi-purpose syringe
DE3120258A1 (en) * 1980-05-22 1982-03-18 Behringwerke Ag, 3550 Marburg Device for the withdrawal of blood, and its use for the separation of blood cells
EP0143292A1 (en) * 1983-10-27 1985-06-05 Uwe Werner Dr. Ballies Device for taking blood samples
US4562844A (en) * 1984-11-27 1986-01-07 Jett Labs, Inc. Multipurpose syringe

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3747812A (en) * 1971-10-21 1973-07-24 Medical Concepts Inc Syringe
US3937211A (en) * 1972-10-27 1976-02-10 Fa. Walter Sarstedt Kunststoff-Spritzgusswerk Multi-purpose syringe
DE3120258A1 (en) * 1980-05-22 1982-03-18 Behringwerke Ag, 3550 Marburg Device for the withdrawal of blood, and its use for the separation of blood cells
EP0143292A1 (en) * 1983-10-27 1985-06-05 Uwe Werner Dr. Ballies Device for taking blood samples
US4562844A (en) * 1984-11-27 1986-01-07 Jett Labs, Inc. Multipurpose syringe

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0643944A1 (en) * 1993-09-22 1995-03-22 B. Braun Melsungen Ag Blood sampling device

Also Published As

Publication number Publication date
EP0262165A1 (en) 1988-04-06
DE8605803U1 (en) 1987-07-02

Similar Documents

Publication Publication Date Title
DE2804788C2 (en)
DE2948653C2 (en) Blood collection device
EP1268301B1 (en) Screw cap with a brush
DE102008057866B4 (en) Chair sampling device
DE1566053A1 (en) Valve device, especially on blood collection devices
EP1060106B1 (en) Container with a discharge nozzle
DE10392369T5 (en) Device for puncturing the skin of a patient
DE3029886A1 (en) BLOOD COLLECTION DEVICE
EP0764118B1 (en) Membrane-sealed tube with a membrane-piercing cap
DE19716073A1 (en) Dosing device for dispensing small amounts of liquid
EP0396882B1 (en) Fixing device for holding fascia-holding-threads, with a conical seal for laparoscopy
DE3702785C2 (en) Liquid ink writing instrument
DE1566638A1 (en) Injection syringe
EP0818159A1 (en) Device for cleaning dirty nails
DE2048415A1 (en) Holder for a writing implement and method for fastening the same
WO1987005198A1 (en) Blood sampling device
DE3736095C2 (en)
DE10243305B4 (en) Swivel spout for sanitary fittings
DE3914290C1 (en)
DE2732518A1 (en) WRITING DEVICE
DE2435236A1 (en) DEVICE FOR FASTENING THE CAP OF A WRITING DEVICE, IN PARTICULAR A FOUNTAIN PEN, ON THE REAR PART
DE4412913C1 (en) Blood removal device
DE3925860A1 (en) Tooth-brush with head, neck and handle - has lengthwise hole along which moves tube, with ridges and duct forming tight seal
DE3042035A1 (en) WRITING, SIGNING, PAINTING OR THE LIKE. DEVICE WITH A REPLACEABLE CARTRIDGE
DE2728969A1 (en) PEN WITH A SLEEVE CONTAINING A PAINTABLE BODY, IN PARTICULAR COSMETIC PEN

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE FR GB IT LU NL SE