WO1987003490A3 - Transdermal delivery system - Google Patents

Transdermal delivery system Download PDF

Info

Publication number
WO1987003490A3
WO1987003490A3 PCT/US1986/002584 US8602584W WO8703490A3 WO 1987003490 A3 WO1987003490 A3 WO 1987003490A3 US 8602584 W US8602584 W US 8602584W WO 8703490 A3 WO8703490 A3 WO 8703490A3
Authority
WO
WIPO (PCT)
Prior art keywords
delivery system
transdermal delivery
weight
carrier
oleic acid
Prior art date
Application number
PCT/US1986/002584
Other languages
French (fr)
Other versions
WO1987003490A2 (en
Inventor
Nicholas Bodor
Thorsteinn Loftsson
Original Assignee
Key Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Key Pharma filed Critical Key Pharma
Priority to KR1019870700681A priority Critical patent/KR900002653B1/en
Priority to DE8787900446T priority patent/DE3688075T2/en
Priority to AT87900446T priority patent/ATE86870T1/en
Publication of WO1987003490A2 publication Critical patent/WO1987003490A2/en
Publication of WO1987003490A3 publication Critical patent/WO1987003490A3/en
Priority to DK407587A priority patent/DK407587A/en
Priority to MYPI87002301A priority patent/MY102378A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A transdermal delivery system comprising nitroglycerine and a carrier which includes 1 to 10 % by weight of oleic acid based on the weight of the carrier and preferably about 5 % by weight of oleic acid together with 50 % or more of 2-ethyl-1,3-hexanediol based on the weight of the carrier.
PCT/US1986/002584 1985-12-06 1986-12-05 Transdermal delivery system WO1987003490A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
KR1019870700681A KR900002653B1 (en) 1985-12-06 1986-12-05 Transdermal delivery system
DE8787900446T DE3688075T2 (en) 1985-12-06 1986-12-05 TRANSDERMAL ADMINISTRATION SYSTEM.
AT87900446T ATE86870T1 (en) 1985-12-06 1986-12-05 TRANSDERMAL DELIVERY SYSTEM.
DK407587A DK407587A (en) 1985-12-06 1987-08-05 TRANSDERMAL SUBMISSION SYSTEM
MYPI87002301A MY102378A (en) 1985-12-06 1987-09-29 Transdermal delivery system.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US806,257 1985-12-06
US06/806,257 US4764381A (en) 1985-12-06 1985-12-06 Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol

Publications (2)

Publication Number Publication Date
WO1987003490A2 WO1987003490A2 (en) 1987-06-18
WO1987003490A3 true WO1987003490A3 (en) 1987-07-30

Family

ID=25193671

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1986/002584 WO1987003490A2 (en) 1985-12-06 1986-12-05 Transdermal delivery system

Country Status (11)

Country Link
US (2) US4764381A (en)
EP (2) EP0250542B1 (en)
JP (1) JPS63502108A (en)
KR (1) KR900002653B1 (en)
AT (1) ATE86870T1 (en)
AU (2) AU602324B2 (en)
CA (1) CA1280974C (en)
DE (1) DE3688075T2 (en)
DK (1) DK407587A (en)
MY (1) MY102378A (en)
WO (1) WO1987003490A2 (en)

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US4931283A (en) * 1983-12-22 1990-06-05 American Home Products Corp. (Del) Menthol enhancement of transdermal drug delivery
US4933184A (en) * 1983-12-22 1990-06-12 American Home Products Corp. (Del) Menthol enhancement of transdermal drug delivery
US4983396A (en) * 1985-12-06 1991-01-08 Key Pharmaceuticals, Inc. Percutaneous penetration enhancer of oleic acid and 2-ethyl-1,3-hexanediol
US5051260A (en) * 1987-07-16 1991-09-24 The Regents Of The University Of California Method and composition for enhancing the cutaneous penetration of pharmacologically active agents
US5045317A (en) * 1987-07-16 1991-09-03 The Regents Of The University Of California Enhancing the cutaneous penetration of pharmacologically active agents
US4971800A (en) * 1988-07-08 1990-11-20 The Regents Of The University Of California Method and compositions for enhancing the cutaneous penetration of pharmacologically active agents
US4994267A (en) * 1988-03-04 1991-02-19 Noven Pharmaceuticals, Inc. Transdermal acrylic multipolymer drug delivery system
US5059603A (en) * 1989-06-12 1991-10-22 Centuries Laboratories, Inc. Method and composition for treating impotence
US5262165A (en) * 1992-02-04 1993-11-16 Schering Corporation Transdermal nitroglycerin patch with penetration enhancers
EP0486529A1 (en) * 1989-08-17 1992-05-27 Schering Corporation Transdermal nitroglycerin patch with penetration enhancers
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US5202125A (en) * 1990-12-10 1993-04-13 Theratech, Inc. Method and systems for administering nitroglycerin transdermally at enhanced transdermal fluxes
US5518734A (en) * 1991-09-25 1996-05-21 Beta Pharmaceuticals Co. Transdermal delivery system for estradiol and process for manufacturing said device
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US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
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US8980290B2 (en) 2000-08-03 2015-03-17 Antares Pharma Ipl Ag Transdermal compositions for anticholinergic agents
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US6727287B2 (en) 2001-04-16 2004-04-27 Pts International, Inc. Toluene sulfonamide-containing anti-tumor composition and method of use thereof
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CA2530407A1 (en) * 2003-07-23 2005-02-03 The Regents Of The University Of California Penetration enhancer combinations for transdermal delivery
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WO2008089242A1 (en) * 2007-01-16 2008-07-24 Dermworx, Incorporated Topical anesthetic for rapid local anesthesia and method of applying a topical anesthetic
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JP5453093B2 (en) * 2007-09-05 2014-03-26 株式会社ポーラファルマ Antifungal pharmaceutical composition
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GB2021950A (en) * 1978-06-05 1979-12-12 Riker Laboratories Inc Nitroglycerin carriers and bandages
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EP0127468A2 (en) * 1983-05-26 1984-12-05 CASSELLA Aktiengesellschaft Percutaneous pharmaceutical preparations for external use
EP0043738B1 (en) * 1980-07-09 1985-10-02 THE PROCTER & GAMBLE COMPANY Penetrating topical pharmaceutical compositions

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DE243661C (en) *
FR1111910A (en) * 1953-11-11 1956-03-06 Boehringer Sohn Ingelheim Process for preparing solidified and moldable masses for cosmetic and pharmaceutical uses
GB2021950A (en) * 1978-06-05 1979-12-12 Riker Laboratories Inc Nitroglycerin carriers and bandages
EP0043738B1 (en) * 1980-07-09 1985-10-02 THE PROCTER & GAMBLE COMPANY Penetrating topical pharmaceutical compositions
EP0121712A1 (en) * 1983-03-03 1984-10-17 The Dow Chemical Company Sustained release compositions from cellulose ethers
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Also Published As

Publication number Publication date
KR900002653B1 (en) 1990-04-21
MY102378A (en) 1992-06-17
AU625830B2 (en) 1992-07-16
ATE86870T1 (en) 1993-04-15
EP0250542A1 (en) 1988-01-07
US4885174A (en) 1989-12-05
EP0393727A3 (en) 1990-11-22
DK407587D0 (en) 1987-08-05
JPS63502108A (en) 1988-08-18
AU6733687A (en) 1987-06-30
DE3688075T2 (en) 1993-06-24
WO1987003490A2 (en) 1987-06-18
DE3688075D1 (en) 1993-04-22
EP0393727A2 (en) 1990-10-24
EP0250542B1 (en) 1993-03-17
CA1280974C (en) 1991-03-05
AU602324B2 (en) 1990-10-11
AU6115890A (en) 1991-02-07
DK407587A (en) 1987-08-05
KR880700675A (en) 1988-04-11
US4764381A (en) 1988-08-16

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