WO1984001292A1 - Procede et conteneur de stockage de plaquettes sanguines - Google Patents
Procede et conteneur de stockage de plaquettes sanguines Download PDFInfo
- Publication number
- WO1984001292A1 WO1984001292A1 PCT/US1983/001290 US8301290W WO8401292A1 WO 1984001292 A1 WO1984001292 A1 WO 1984001292A1 US 8301290 W US8301290 W US 8301290W WO 8401292 A1 WO8401292 A1 WO 8401292A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- container
- platelet
- range
- gtr
- storage container
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 28
- 238000003860 storage Methods 0.000 claims abstract description 73
- 230000035899 viability Effects 0.000 claims abstract description 18
- 230000035699 permeability Effects 0.000 claims abstract description 16
- 239000002861 polymer material Substances 0.000 claims abstract description 11
- 239000000463 material Substances 0.000 claims description 74
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 25
- 239000004800 polyvinyl chloride Substances 0.000 claims description 25
- 239000003634 thrombocyte concentrate Substances 0.000 claims description 21
- 229920000098 polyolefin Polymers 0.000 claims description 11
- 239000004698 Polyethylene Substances 0.000 claims description 10
- -1 polyethylene Polymers 0.000 claims description 10
- 229920000573 polyethylene Polymers 0.000 claims description 10
- 239000012141 concentrate Substances 0.000 claims description 3
- 238000001990 intravenous administration Methods 0.000 claims description 3
- 229920005570 flexible polymer Polymers 0.000 claims description 2
- 239000012611 container material Substances 0.000 abstract description 4
- 238000006243 chemical reaction Methods 0.000 abstract description 2
- 230000005540 biological transmission Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 22
- 239000011347 resin Substances 0.000 description 12
- 229920005989 resin Polymers 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 11
- 239000008280 blood Substances 0.000 description 11
- 239000004014 plasticizer Substances 0.000 description 11
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 8
- 238000012546 transfer Methods 0.000 description 8
- 239000012760 heat stabilizer Substances 0.000 description 7
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 6
- 235000013539 calcium stearate Nutrition 0.000 description 6
- 239000008116 calcium stearate Substances 0.000 description 6
- 229910002092 carbon dioxide Inorganic materials 0.000 description 5
- 239000001993 wax Substances 0.000 description 5
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 5
- KRADHMIOFJQKEZ-UHFFFAOYSA-N Tri-2-ethylhexyl trimellitate Chemical compound CCCCC(CC)COC(=O)C1=CC=C(C(=O)OCC(CC)CCCC)C(C(=O)OCC(CC)CCCC)=C1 KRADHMIOFJQKEZ-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000002386 leaching Methods 0.000 description 4
- 230000006641 stabilisation Effects 0.000 description 4
- 238000011105 stabilization Methods 0.000 description 4
- 235000015112 vegetable and seed oil Nutrition 0.000 description 4
- 239000008158 vegetable oil Substances 0.000 description 4
- 239000012503 blood component Substances 0.000 description 3
- 239000001569 carbon dioxide Substances 0.000 description 3
- 238000003306 harvesting Methods 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 101100230376 Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) celI gene Proteins 0.000 description 1
- 241000288673 Chiroptera Species 0.000 description 1
- 229920006385 Geon Polymers 0.000 description 1
- 229920012485 Plasticized Polyvinyl chloride Polymers 0.000 description 1
- 239000004930 VINNOL Substances 0.000 description 1
- 229920004482 WACKER® Polymers 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- HRBZRZSCMANEHQ-UHFFFAOYSA-L calcium;hexadecanoate Chemical compound [Ca+2].CCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCC([O-])=O HRBZRZSCMANEHQ-UHFFFAOYSA-L 0.000 description 1
- 238000003490 calendering Methods 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 235000021388 linseed oil Nutrition 0.000 description 1
- 239000000944 linseed oil Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 239000011342 resin composition Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 239000011232 storage material Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 229940012185 zinc palmitate Drugs 0.000 description 1
- GJAPSKMAVXDBIU-UHFFFAOYSA-L zinc;hexadecanoate Chemical compound [Zn+2].CCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCC([O-])=O GJAPSKMAVXDBIU-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0263—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0427—Platelets; Thrombocytes
Definitions
- the present invention relates to the storage of blood components. More particularly, the present invention relates to the storage of platelets in concentrated form.
- Blood may be collected and processed under sterile conditions to obtain various blood components as may be desired, such as packed red cells, plasma, platelets and cryoprecipitate, for example.
- the individual components may then be stored for a limited period of time and then utilized as desired.
- platelet concentrates may be used in the treatment of thrombocytopenia. Since platelets are generally stored for a period of time before use, effective storage techniques are needed.
- preferred storage conditions for platelet concentrates include storage in medical grade polyvinyl chloride (PYC) bags at about 22°C.
- PYC polyvinyl chloride
- Several available storage bags for platelets contain polyvinyl chloride materials which are heat stabilized with epoxidized vegetable oils.
- Typical epoxidized vegetable oils which are used as heat stabilizers for PVC include epoxidized soybean oil and epoxidized linseed oil.
- PVC polyvinyl chloride
- Typical epoxidized vegetable oils which are used as heat stabilizers for PVC include epoxidized soybean oil and epoxidized linseed oil.
- such platelet storage bags are disclosed in U.S. Patent No. 4,280,497 to Warner et al.
- a unit of platelet concentrate (the amount of platelet concentrate obtained from a unit of blood) whould have at least 0.55 x 10 11 viable platelets according to the American Association of Blood Banks.
- a unit of platelets will contain from about 0.55 x 10 11 to about 1.5 x 10 11 platelet cells.
- the amount of platelet cells obtained from a unit of blood can vary widely.
- a unit of platelet cells contains from about 0.55 x 10 11 to about 1.5 x 10 11 .
- the absolute number of platelet cells present in a unit of normal human blood can be as high as about 2.0 x 10 11 .
- Currently available platelet cell harvesting techniques generally permit harvesting about 80%, or in some cases, about 90%, of the total number of platelets present in whole blood. It is anticipated that in the future, improved harvesting techniques may become available, and such improved techniques will not affect the spirit or scope of the present invention and appended claims.
- the number of platelets present in a container markedly affects the storage characteristics of the platelets. Since the number of platelets collected from a unit of blood generally varies between about 0.55 x 10 11 and 1.5 x 10 11 , it would be highly desirable to be able to provide a container and method for storing platelets which optimize storage conditions for this particular number or number range of platelet cells or some, other number or number range of platelet cells in order to maximize the storage time and viability of the stored platelet cells.
- certain types of storage conditions are more conducive to platelet viability over storage periods of up to at least five days. More specifically, it has been discovered that improved platelet viability results when platelet cells are stored in a container which has a carbon dioxide gas permeability transfer rate through the container within a certain range relative to the number of platelet cells stored therein. Platelet viability of the stored cells diminishes when the carbon dioxide permeability transfer rate is not within the specified range, thus, it has been discovered that either too little or too much carbon dioxide gas transfer through the container is deleterious to the viability of stored platelets.
- the container should be such that the following range is satisfied: 110 ⁇ R ⁇ 360 wherein and wherein R is in units of (nanomoles CO 2 )x(min. x 10 11 platelet cel l s-cm Hg co2 ) ; C represents a unit conversion constant of 2.68 x 10 -4 in units of (nanomoles-sec)/(cc-min) ; represents the CO 2 gas permeabil ity constant for the container material in units of barrer SA represents the total surface area of the container in square centimeters; and
- FT represents the thickness of the container material in centimeters.
- the container should meet the R value requirements for any number of platelet cells between 0.55 x 10 11 and 1.5 x 10 11 .
- the number of platelet cells to be stored therein will be greater than about 0.75 x
- an improved platelet storage container for maintaining a unit of plaatelets at an acceptable level of viability is provided wherein the gas transfer rate (GTR) of the container satisfies the following range: 85 ⁇ GTR ⁇ 180
- GTR is in units of (nanomoles)/(min.-cm
- a method of storing platelet cells includes containing the platelet cells in a container wherein the following range is satisfied: 110 ⁇ R ⁇ 360
- R, C, PCO 2 , SA and FT being the same variables as in equation (1) and generally, more than about 0.75 x 10 11 platelet cells are stored therein.
- a method of storing a unit of platelet cells includes containing the unit of platelet cells in a container wherein the following range is satisfied:
- a container suitable for storing platelets and having a concentrate of platelet cells stored therein includes a container which satisfies the following range:
- the container will have at least about 0.75 x 10 11 platelet cells stored therein.
- a container having a concentrated unit of viable platelet cells stored therein which is suitable for intravenous use includes a container which satisfies the range: 85 ⁇ GTR ⁇ 180 wherein the variables being as previously defined.
- the number of platelet cells to be stored in the container can be set forth as a number range so that an optimum storage container with a specific GTR is provided for the number range of platelet cells that will be encountered.
- optimized containers for storing a unit of platelet cells are provided.
- a method for manufacturing a platelet storage container of the proper size, volume and thickness for storing a given number or range of platelet cells under improved conditions so that an acceptable level of platelet viability is maintained during storage.
- a platelet storage container is manufactured for containing a number or number range of platelet cells in which the following range is satisfied: 110 ⁇ R ⁇ 360,
- the number of platelet cells to be stored in the container will be greater than about 0.75 x 10 11 .
- the container will be constructed of a flexible polymer film material of a suitable type.
- suitable types of polymers include plastlcized polyvinyl chloride compositions, polyethylene materials and polyolefin materials.
- Fig. 1 is a plan view of a platelet storage container in accordance with the invention.
- platelet storage container in accordance with the present invention which is a platelet storage bag 10.
- Platelet storage bag 10 may be of conventional construction, with the exception of the type of materials of which it is made and the size and thickness of the container.
- platelet storage bag 10 includes an inlet port 14 to which is connected a length of flexible tubing 16 to a donor bag (not shown), for example. Alternately, tubing 16 may communicate with the interior of another container (not shown).
- the container includes a number of normally sealed, selectively operable access ports 12.
- the container satisfies the range 110 ⁇ R ⁇ 360.
- R is greater than 120 and even more preferably, R is greater than 140.
- R is greater than 160.
- R is less than 270 and most preferably, R is less than 210.
- the gas transfer rate, "GTR" is within the range 85 ⁇ GTR ⁇ 180.
- GTR is within the range 100 ⁇ GTR ⁇ 170 and more preferably 120 ⁇ GTR ⁇ 170.
- the most preferred range for GTR for storing a unit of platelet cells is from about 160 to about 170.
- a platelet storage container can be provided which is optimized for storing a number of platelet cells within a given range.
- a container is provided such that the GTR of the container preferably provides an R value within the range of 110 ⁇ R ⁇ 360 and more preferably 120 ⁇ R ⁇ 270 for the entire range of platelet cells which may be stored in the container.
- the GTR of the container preferably provides an R value within the range of 110 ⁇ R ⁇ 360 and more preferably 120 ⁇ R ⁇ 270 for the entire range of platelet cells which may be stored in the container.
- an optimum platelet container is desired for storage of a unit of platelet concentrate, which generally may contain from about 0.5 x 10 11 to about 1.5 x 10 11 platelet cells
- a container having a GTR of 165 would have an R of 110 when 1.5 x 10 11 platelets are stored therein and an R of 330 when 0.5 x 10 11 platelets are stored therein.
- an R value could be provided within the more preferred R range of 120 ⁇ R ⁇ 270.
- storage of platelet celIs in a container having a GTR of between about 150 and 180 would always result in an R value in the range of 120 ⁇ R ⁇ 240 when from 0.75 x 10 11 to 1.25 x 10 11 platelet cells are stored therein.
- the invention allows platelet storage containers to be optimized for storage of a wide range of platelet cells, such as the range encountered when units of platelet concentrate are obtained from units of blood.
- Platelet storage bag 10 may be constructed of a material of a suitable type.
- polymer material such as a plasticized polyvinyl chloride resin compositions, polyethylene material and polyolefin material may be used.
- Such materials may be plasticized and heat stabilized as desired by any suitable material or materials known to those skilled in the art, as long as the resulting material is suitable for storing platelets and the value of R or GTR is within the desired range.
- Other types of materials, polymers or nonpolymers, may be used, as long as the requirements for gas transfer are provided.
- combinations of materials could be used and materials having various thickness could also be used, as long as the overall gas transfer requirements are met.
- a container could have a very thick, relatively non-porous portion or portions with other portions of the container being relatively porous, as long as the overall gas transfer requirements are met.
- the invention is not limited to containers of a certain material or design or to materials having a uniform thickness. Polymers and polymer films are generally useful in practicing the invention.
- one preferred type of polyvinyl chloride composition includes PVC resin, an effective amount of tri-(2-ethylhexyl) trimellitate to plasticize the PVC, less than about one percent by weight of the total composition of the heat stabilization system and optionally an effective amount of an antiblock agent.
- the amount of plasticizer can be chosen such that the desired degree of flexibility is obtained.
- Compositions containing a relatively low quantity of plasticizer may be harder and less flexible than desired and those with a relatively high quantity of plasticizer may be softer and more flexible than desired.
- an effective amount of plasticizer for this type of composition will be from about 25 to 90 parts per 100 parts resin by weight.
- the amount of plasticizer is from about 63 to 85 parts per 100 parts resin by weight and most preferably about 74 parts.
- the heat stabilization system should generally be present in an amount greater than about 0.15 percent by weight of the total composition and is preferably present in an amount of between about 0.26 and 0.35 parts per 100 parts resin by weight. Generally, as the amount of heat stabilizer is increased, increased leaching occurs and hazing may also result if the amount of heat stabilizer is high enough.
- the antiblock agent when utilized, will be present in an amount sufficient to provide the desired antiblock effect, or stated otherwise, to prevent adhesion of films made from the composition.
- the amount of antiblock agent will usually be from about 0.2 to about 0.6 parts per 100 parts resin by weight and preferably about 0.4 parts. Again, generally as the amount of wax increases, increased leaching also results.
- the preferred amount of antiblock agent is generally the minimum amount which will prevent adhesion of films made from the composition.
- An especially preferred composition is, per 100 parts of PVC resin, 74 parts of tri(2-ethylhexyl) trimellitate, 0.3 parts of a calcium stearate and zinc stearate heat stabilizer sold by the trade designation "CZ-11-P" by the Interstab
- Such a composition has a at 25°C of about 49 bar.
- the ingredients of a composition can generally be suitably mixed by a blender, for example.
- a composition can be formed into sheets by conventional methods such as by calendaring or by extrusion to a desired thickness.
- a mixing screw type apparatus may be used in extruding the material.
- the materials are processed under suitable conditions so that unacceptable heat degradation or color change of the material does not occur.
- the type and amount of heat stabilizer will affect the processing conditions to which the composition may be subjected without the occurrence of significant degradation or color change. For example, a PVC composition without calcium stearate is more likely to undesirably darken during processing than a PVC composition containing calcium stearate and zinc stearate.
- the polyvinyl chloride resin can be any suitable type. Those types of PVC resins which relatively easily absorb the plasticizer are preferred. Especially suitable resins are those known as "blotter” resins. One such preferred resin is marketed by the B.F. Goodrich Chemical Co. under the trade designation “GEON 80X80.” Another preferred resin is marketed by the Wacker Co. under the trade designation "VINNOL H70DF”.
- the plasticizer which may be utilized tri(2-ethylhexyl) trimellitate, is commercially available.
- One source is the Hatco Chemical Corp. marketing the plasticizer under the trade designation "HATCOL 200".
- the heat stabilization system may be calcium stearate, zinc stearate or mixtures thereof. More generally, the heat stabilization system can be at least one salt of C 10 to C 26 saturated fatty acids. A 1:1 weight ratio of zinc stearate/calcium stearate is preferred. A suitable co ⁇ mercial source of the zinc stearate/calcium stearate combination is the Interstab Company which markets such a heat stabilizer under the trade designation "CZ-11-P". "CZ-11-P" formulation may also contain minor amounts of calcium palmitate, zinc palmitate and C 18 fatty acids.
- the antiblock agent which may be present generally may be any material that provides the desired antiblock effect without an undesired degree of leaching and which is not otherwise objectionable.
- Preferred antiblock agents are low viscosity, high melting point waxes, such as wax marketed under the trade designation "Acrawax C" by Glycol Chemicals, Inc. High viscosity oils may also be utilized. In general, oils will leach to a greater degree than waxes. Mixtures of antiblock agents may also be used. Reference is made to United States Patent Application Serial No. 424,679 filed September 27, 1982 for a more complete description of such PVC compositions. Other PVC compositions may contain an epoxidized vegetable oil or oils which function as a heat stabilizer. Such compositions are disclosed in U.S. Patent No.4,280,497 to Warner et al. and reference is made thereto for further descriptions thereof. However, it should be kept in mind that the scope and spirit of the present invention is not limited to particular materials or compositions.
- the thickness of the polymer material will be between about 0.01 centimeter and 0.05 centimeter.
- platelet storage materials may be used including those previously described and other which are known to those skilled in the art.
- Bag Volume/Surface Area 300 ml/365 cm 2 1000 ml/644 cm 2
- Bag Volume/Surface Area 300 ml/280 cm 2 600 ml/398 cm 2
- Thickness 300 ml bag: 0.015 cm 600 ml bag: 0.015 cm
- Thickness 0.038 cm
- Platelet concentrate was obtained from single units of blood or from a continuous centrifugation system in which blood was continuously withdrawn, centrifuged to remove platelets and returned to the donor.
- the platelets were stored at ambient temperature and the following results were obtained after storage for about three and five days:
Abstract
Procédés et conteneurs de stockage de cellules de plaquettes sanguines. Selon un aspect de l'invention, un conteneur amélioré de stockage d'une unité de cellules de plaquettes sanguines à un niveau acceptable de viabilité est fabriqué avec un matériau polymère, et ce conteneur remplit les conditions suivantes de vitesse de transmission de gaz: 85 <= GTR <= 180; dans cette relation, GTR =$(6,)$où GTR et calculé en unités de (nanomoles)/(min.-cm Hgco2); C est une constante de conversion d'unités de 2,68 x 10-4 en unités de (nanomoles-sec.)/(cc-min.); Pco2 est la constante de perméabilité du gaz CO2 pour le matériau du conteneur en unités de barrière$(7,)$SA est la surface totale du conteneur en centimètres carrés; et FT est l'épaisseur du matériau du conteneur en centimètres; selon l'invention, des conteneurs et des procédés sont décrits, lesquels permettent une optimisation du stockage d'un nombre particulier ou plage de nombres de cellules de plaquettes sanguines de manière à rendre la viabilité et le temps de stockage maximum.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU19470/83A AU1947083A (en) | 1982-09-27 | 1983-08-22 | Method and container for storing platelets |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42467882A | 1982-09-27 | 1982-09-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1984001292A1 true WO1984001292A1 (fr) | 1984-04-12 |
Family
ID=23683483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1983/001290 WO1984001292A1 (fr) | 1982-09-27 | 1983-08-22 | Procede et conteneur de stockage de plaquettes sanguines |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0120875A4 (fr) |
JP (1) | JPS59501733A (fr) |
CA (1) | CA1227432A (fr) |
WO (1) | WO1984001292A1 (fr) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1986002545A1 (fr) * | 1984-10-29 | 1986-05-09 | Bellhouse Medical Products Limited | Poche a sang |
US5683768A (en) * | 1994-12-21 | 1997-11-04 | Baxter International Inc. | Plastic formulations for platelet storage containers and the like |
WO2005039291A2 (fr) * | 2003-10-22 | 2005-05-06 | Fred Hutchinson Cancer Research Center | Methodes, compositions et dispositifs permettant d'induire une stase dans des cellules |
EP2685815A2 (fr) * | 2011-03-16 | 2014-01-22 | Mayo Foundation For Medical Education And Research | Procédés et matériaux pour prolonger le stockage utile des préparations d'hématies et des préparations de plaquettes |
US9140223B2 (en) | 2008-12-29 | 2015-09-22 | C.R.F. SOCIETá CONSORTILE PER AZIONI | Fuel injection system with high repeatability and stability of operation for an internal-combustion engine |
US9440011B2 (en) | 2012-07-12 | 2016-09-13 | Terumo Bct, Inc. | Hybrid blood component storage bag and method of making such bag |
WO2023197518A1 (fr) * | 2022-04-13 | 2023-10-19 | 西安北光医学生物技术有限公司 | Procédé de conservation contre les lésions et système de conservation pour des cellules, des tissus ou des organes |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0435670A (ja) * | 1990-05-31 | 1992-02-06 | Nissho Corp | 血液分離装置 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3928294A (en) * | 1972-02-22 | 1975-12-23 | Owens Illinois Inc | Biocompatible articles including polymeric membranes having high permeability to gases and uses thereof |
AU489541B2 (en) * | 1976-08-24 | 1978-01-19 | Green Cross Corporation, The | Medical appliance made of plastic |
US4082509A (en) * | 1976-08-05 | 1978-04-04 | Dow Corning Corporation | Method of storing blood and a blood storage bag therefor |
BE862722A (fr) * | 1977-01-08 | 1978-05-02 | Terumo Corp | Ustensile medical |
US4132594A (en) * | 1976-06-28 | 1979-01-02 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Gas diffusion liquid storage bag and method of use for storing blood |
US4228032A (en) * | 1978-11-06 | 1980-10-14 | Dow Corning Corporation | Method of storing blood and a blood storage bag therefore |
JPS5676955A (en) * | 1979-11-27 | 1981-06-24 | Sekisui Chemical Co Ltd | Manufacture of medical resin molding |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4496361A (en) * | 1981-08-05 | 1985-01-29 | E. I. Du Pont De Nemours And Company | Platelet storage container |
-
1983
- 1983-08-22 WO PCT/US1983/001290 patent/WO1984001292A1/fr not_active Application Discontinuation
- 1983-08-22 EP EP19830902868 patent/EP0120875A4/fr active Pending
- 1983-08-22 JP JP50291883A patent/JPS59501733A/ja active Pending
- 1983-09-15 CA CA000436747A patent/CA1227432A/fr not_active Expired
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US3928294A (en) * | 1972-02-22 | 1975-12-23 | Owens Illinois Inc | Biocompatible articles including polymeric membranes having high permeability to gases and uses thereof |
US4132594A (en) * | 1976-06-28 | 1979-01-02 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Gas diffusion liquid storage bag and method of use for storing blood |
US4082509A (en) * | 1976-08-05 | 1978-04-04 | Dow Corning Corporation | Method of storing blood and a blood storage bag therefor |
US4162676A (en) * | 1976-08-05 | 1979-07-31 | Dow Corning Corporation | Blood bag having co2 absorbent therein |
AU489541B2 (en) * | 1976-08-24 | 1978-01-19 | Green Cross Corporation, The | Medical appliance made of plastic |
BE862722A (fr) * | 1977-01-08 | 1978-05-02 | Terumo Corp | Ustensile medical |
US4228032A (en) * | 1978-11-06 | 1980-10-14 | Dow Corning Corporation | Method of storing blood and a blood storage bag therefore |
JPS5676955A (en) * | 1979-11-27 | 1981-06-24 | Sekisui Chemical Co Ltd | Manufacture of medical resin molding |
Non-Patent Citations (1)
Title |
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See also references of EP0120875A4 * |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1986002545A1 (fr) * | 1984-10-29 | 1986-05-09 | Bellhouse Medical Products Limited | Poche a sang |
US4675019A (en) * | 1984-10-29 | 1987-06-23 | Bellhouse Medical Products Limited | Blood monitoring system |
US4758083A (en) * | 1984-10-29 | 1988-07-19 | Bellhouse Technology Limited | Blood monitoring system |
US5683768A (en) * | 1994-12-21 | 1997-11-04 | Baxter International Inc. | Plastic formulations for platelet storage containers and the like |
US7993681B2 (en) | 2003-10-22 | 2011-08-09 | Fred Hutchinson Cancer Research Center | Methods, compositions and devices for inducing stasis in tissues and organs |
WO2005039291A3 (fr) * | 2003-10-22 | 2005-08-25 | Hutchinson Fred Cancer Res | Methodes, compositions et dispositifs permettant d'induire une stase dans des cellules |
WO2005039291A2 (fr) * | 2003-10-22 | 2005-05-06 | Fred Hutchinson Cancer Research Center | Methodes, compositions et dispositifs permettant d'induire une stase dans des cellules |
US9140223B2 (en) | 2008-12-29 | 2015-09-22 | C.R.F. SOCIETá CONSORTILE PER AZIONI | Fuel injection system with high repeatability and stability of operation for an internal-combustion engine |
EP2685815A2 (fr) * | 2011-03-16 | 2014-01-22 | Mayo Foundation For Medical Education And Research | Procédés et matériaux pour prolonger le stockage utile des préparations d'hématies et des préparations de plaquettes |
EP2685815A4 (fr) * | 2011-03-16 | 2014-09-17 | Mayo Foundation | Procédés et matériaux pour prolonger le stockage utile des préparations d'hématies et des préparations de plaquettes |
US9315775B2 (en) | 2011-03-16 | 2016-04-19 | Mayo Foundation For Medical Education And Research | Methods and materials for prolonging useful storage of red blood cell preparations and platelet preparations |
US9440011B2 (en) | 2012-07-12 | 2016-09-13 | Terumo Bct, Inc. | Hybrid blood component storage bag and method of making such bag |
WO2023197518A1 (fr) * | 2022-04-13 | 2023-10-19 | 西安北光医学生物技术有限公司 | Procédé de conservation contre les lésions et système de conservation pour des cellules, des tissus ou des organes |
Also Published As
Publication number | Publication date |
---|---|
EP0120875A1 (fr) | 1984-10-10 |
CA1227432A (fr) | 1987-09-29 |
JPS59501733A (ja) | 1984-10-18 |
EP0120875A4 (fr) | 1985-12-05 |
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