USRE45384E1 - Electrochemical-sensor design - Google Patents
Electrochemical-sensor design Download PDFInfo
- Publication number
- USRE45384E1 USRE45384E1 US14/022,189 US201314022189A USRE45384E US RE45384 E1 USRE45384 E1 US RE45384E1 US 201314022189 A US201314022189 A US 201314022189A US RE45384 E USRE45384 E US RE45384E
- Authority
- US
- United States
- Prior art keywords
- working electrode
- sensor
- sub
- test sample
- counter electrode
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
Abstract
Description
-
- 1) a base which provides a flow path for the fluid test sample having on its surface a counter electrode and a working electrode in electrical communication with a detector of electrical current,
- 2) a reaction layer on the surface of at least the working electrode which contains an enzyme which reacts with the analyte to produce electrons that are transferred to the working electrode, and
- 3) a cover which when mated with the base member forms a capillary space with an opening for the introduction of fluid test sample into this space. The capillary space encloses the flow path for the fluid test sample in which the counter and working electrodes are contained. These electrodes are situated on the base in relation to the opening so that a major portion of the counter electrode is located downstream of the opening from the working electrode. The counter electrode contains a sub-element which is located upstream of the working electrode, so that when electrical communication between only the sub-element of the counter electrode and working electrode due to incomplete filling of the capillary space by the fluid test sample occurs, there is insufficient flow of electrical current through the detector to constitute a valid test for the concentration of analyte in the fluid test sample. In the event of such insufficient flow of electrical current, the detector gives an error signal to notify the user that the test has failed and that it should be repeated.
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- a) making multiple current measurements at different time periods when a driving potential is applied between the electrodes;
- b) converting the multiple current measurements into error checking parameters; and
- c) checking the values of the error checking parameters against their corresponding tolerance limits to determine if a short fill has occurred.
Note: k characterizes how the current decays in a general current-glucose relationship I=c·G·t−k, where I is the current, c is a constant, G is the glucose concentration, and t is the time.
The Read-to-Burn ratio, R/B is defined as:
R/B=Ir10/Ib10 Eq. 2
if |k−(ak1+bk1·G)|>wk is true when G≦dk1, or
if |k−(ak2+bk2·G)|>wk is true when dk1<G≦dk2, or
if |k−(ak3+bk3·G)|>wk is true when G>dk2 Eq. 3
where ak1, ak2, ak3, bk1, bk2, bk3, wk, dk1, dk2 and dk3 are predetermined constants, G is the glucose measurement.
Condition 2 (R/B ratio checking):
if |R/B−(ac1+bc1·G)|>wc is true when G≦dc, or
if |R/B−(ac2+bc2·G)|>wc is true when G>dc Eq. 4
where ac1, ac2, bc1, bc2, wc, and dc are predetermined constants, G is the glucose measurement.
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- Tests a large number of sensors at various glucose levels, G.
- Calculates the decay factor, k, of each sensor from their Ib5 and Ib10 currents.
- Plots all the data points in a k vs. G chart.
- Fits a 3-piece piecewise-linear line to the data points in the k vs. G chart. These three pieces are ak1+bk1×G for G≦dk1; ak2+bk2×G for G>dk1 and ≦dk2; and ak3+bk3×G for G>dk2
- Add a tolerance width of ±wk to the three lines so that the band between the −wk and +wk is wide enough to enclose all the normal data points in the chart.
The constants ac's, bc's, dc and wc in Eq. 4 are also predetermined experimentally in the same way, on a R/B vs. G chart.
A sample calculation is as follows:
- Step A—Make three current measurements of a sensor:
- Ib10=505.1 nA, Ir5=656.5 nA, and Ir10=561.8 nA.
- Step B—Determine the value of the decay factor k and R/B ratio:
- The decay factor and read-to-burn ratio were calculated from the current measurements:
- Decay factor
-
- Read-to-Burn ratio
R/B=Ir10/Ib10=561.8/505.1=1.11
- Read-to-Burn ratio
- Step C—Check against the tolerance limits:
- The constants used in this example were:
- ak1=0.36, bk1=−0.0002 dL/mg, wk=0.13, and dk1=100 mg/dL
The glucose reading from the sensor system is 22.9 mg/dL.
Condition 1 was true because of the first line in Eq. 3 was true.
if |k−(ak1+bk1·G)|>wk is true when G≦dk1
|0.225−(0.36−0.0002·22.9)|=0.1304>0.13 is true when G=22.9≦dk1=100
No further check on Condition 2 was needed in this example, because Condition 1 was already true.
Therefore, this sensor was determined as a short fill.
Claims (35)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/022,189 USRE45384E1 (en) | 1999-08-02 | 2013-09-09 | Electrochemical-sensor design |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36626999A | 1999-08-02 | 1999-08-02 | |
US09/731,943 US6531040B2 (en) | 1999-08-02 | 2000-12-08 | Electrochemical-sensor design |
US09/861,437 US6841052B2 (en) | 1999-08-02 | 2001-05-21 | Electrochemical-sensor design |
US10/864,011 US7125481B2 (en) | 1999-08-02 | 2004-06-09 | Electrochemical-sensor design |
US12/257,031 USRE44521E1 (en) | 1999-08-02 | 2008-10-23 | Electrochemical-sensor design |
US14/022,189 USRE45384E1 (en) | 1999-08-02 | 2013-09-09 | Electrochemical-sensor design |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/864,011 Reissue US7125481B2 (en) | 1999-08-02 | 2004-06-09 | Electrochemical-sensor design |
Publications (1)
Publication Number | Publication Date |
---|---|
USRE45384E1 true USRE45384E1 (en) | 2015-02-24 |
Family
ID=33134759
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/861,437 Expired - Lifetime US6841052B2 (en) | 1999-08-02 | 2001-05-21 | Electrochemical-sensor design |
US10/864,011 Ceased US7125481B2 (en) | 1999-08-02 | 2004-06-09 | Electrochemical-sensor design |
US12/257,031 Expired - Fee Related USRE44521E1 (en) | 1999-08-02 | 2008-10-23 | Electrochemical-sensor design |
US14/022,189 Expired - Fee Related USRE45384E1 (en) | 1999-08-02 | 2013-09-09 | Electrochemical-sensor design |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/861,437 Expired - Lifetime US6841052B2 (en) | 1999-08-02 | 2001-05-21 | Electrochemical-sensor design |
US10/864,011 Ceased US7125481B2 (en) | 1999-08-02 | 2004-06-09 | Electrochemical-sensor design |
US12/257,031 Expired - Fee Related USRE44521E1 (en) | 1999-08-02 | 2008-10-23 | Electrochemical-sensor design |
Country Status (1)
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US (4) | US6841052B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10948475B2 (en) * | 2006-09-18 | 2021-03-16 | Cfph, Llc | Products and processes for analyzing octane content |
Families Citing this family (109)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE227844T1 (en) | 1997-02-06 | 2002-11-15 | Therasense Inc | SMALL VOLUME SENSOR FOR IN-VITRO DETERMINATION |
US6036924A (en) | 1997-12-04 | 2000-03-14 | Hewlett-Packard Company | Cassette of lancet cartridges for sampling blood |
US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
US6338790B1 (en) | 1998-10-08 | 2002-01-15 | Therasense, Inc. | Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator |
US6841052B2 (en) | 1999-08-02 | 2005-01-11 | Bayer Corporation | Electrochemical-sensor design |
CN100363739C (en) | 1999-11-15 | 2008-01-23 | 松下电器产业株式会社 | Biosensor, method of forming thin-film electrode, and method and apparatus for quantitative determination |
DE10057832C1 (en) * | 2000-11-21 | 2002-02-21 | Hartmann Paul Ag | Blood analysis device has syringe mounted in casing, annular mounting carrying needles mounted behind test strip and being swiveled so that needle can be pushed through strip and aperture in casing to take blood sample |
US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
WO2002044705A1 (en) * | 2000-11-30 | 2002-06-06 | Matsushita Electric Industrial Co., Ltd. | Biosensor, measuring instrument for biosensor, and method of quantifying substrate |
AU784254B2 (en) * | 2001-05-21 | 2006-03-02 | Bayer Corporation | Improved electrochemical sensor |
ES2336081T3 (en) | 2001-06-12 | 2010-04-08 | Pelikan Technologies Inc. | SELF-OPTIMIZATION PUNCTURE DEVICE WITH MEANS OF ADAPTATION TO TEMPORARY VARIATIONS IN CUTANEOUS PROPERTIES. |
US7025774B2 (en) | 2001-06-12 | 2006-04-11 | Pelikan Technologies, Inc. | Tissue penetration device |
DE60238119D1 (en) | 2001-06-12 | 2010-12-09 | Pelikan Technologies Inc | ELECTRIC ACTUATOR ELEMENT FOR A LANZETTE |
JP4272051B2 (en) | 2001-06-12 | 2009-06-03 | ペリカン テクノロジーズ インコーポレイテッド | Blood sampling apparatus and method |
US20070100255A1 (en) * | 2002-04-19 | 2007-05-03 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
WO2002100254A2 (en) | 2001-06-12 | 2002-12-19 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
EP1404234B1 (en) | 2001-06-12 | 2011-02-09 | Pelikan Technologies Inc. | Apparatus for improving success rate of blood yield from a fingerstick |
CA2419213C (en) * | 2002-03-07 | 2011-06-21 | Bayer Healthcare Llc | Improved electrical sensor |
US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US7331931B2 (en) | 2002-04-19 | 2008-02-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7229458B2 (en) | 2002-04-19 | 2007-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7708701B2 (en) | 2002-04-19 | 2010-05-04 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device |
US7524293B2 (en) * | 2002-04-19 | 2009-04-28 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7297122B2 (en) | 2002-04-19 | 2007-11-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7410468B2 (en) * | 2002-04-19 | 2008-08-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
US7547287B2 (en) | 2002-04-19 | 2009-06-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7491178B2 (en) | 2002-04-19 | 2009-02-17 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7901362B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
US7717863B2 (en) | 2002-04-19 | 2010-05-18 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8360992B2 (en) | 2002-04-19 | 2013-01-29 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7244265B2 (en) * | 2002-04-19 | 2007-07-17 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
US7291117B2 (en) * | 2002-04-19 | 2007-11-06 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7648468B2 (en) | 2002-04-19 | 2010-01-19 | Pelikon Technologies, Inc. | Method and apparatus for penetrating tissue |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7371247B2 (en) | 2002-04-19 | 2008-05-13 | Pelikan Technologies, Inc | Method and apparatus for penetrating tissue |
US7232451B2 (en) | 2002-04-19 | 2007-06-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7175642B2 (en) | 2002-04-19 | 2007-02-13 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
US8372016B2 (en) | 2002-04-19 | 2013-02-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling and analyte sensing |
US7265881B2 (en) * | 2002-12-20 | 2007-09-04 | Hewlett-Packard Development Company, L.P. | Method and apparatus for measuring assembly and alignment errors in sensor assemblies |
US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
US7132041B2 (en) * | 2003-02-11 | 2006-11-07 | Bayer Healthcare Llc | Methods of determining the concentration of an analyte in a fluid test sample |
ATE476137T1 (en) | 2003-05-30 | 2010-08-15 | Pelikan Technologies Inc | METHOD AND DEVICE FOR INJECTING LIQUID |
DK1633235T3 (en) | 2003-06-06 | 2014-08-18 | Sanofi Aventis Deutschland | Apparatus for sampling body fluid and detecting analyte |
WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
US8206565B2 (en) * | 2003-06-20 | 2012-06-26 | Roche Diagnostics Operation, Inc. | System and method for coding information on a biosensor test strip |
US8058077B2 (en) | 2003-06-20 | 2011-11-15 | Roche Diagnostics Operations, Inc. | Method for coding information on a biosensor test strip |
US7645421B2 (en) | 2003-06-20 | 2010-01-12 | Roche Diagnostics Operations, Inc. | System and method for coding information on a biosensor test strip |
US7718439B2 (en) * | 2003-06-20 | 2010-05-18 | Roche Diagnostics Operations, Inc. | System and method for coding information on a biosensor test strip |
EP1671096A4 (en) | 2003-09-29 | 2009-09-16 | Pelikan Technologies Inc | Method and apparatus for an improved sample capture device |
EP1680014A4 (en) | 2003-10-14 | 2009-01-21 | Pelikan Technologies Inc | Method and apparatus for a variable user interface |
WO2005040407A1 (en) | 2003-10-24 | 2005-05-06 | Bayer Healthcare Llc | Enzymatic electrochemical biosensor |
EP1706026B1 (en) | 2003-12-31 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Method and apparatus for improving fluidic flow and sample capture |
US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
AU2005213658A1 (en) * | 2004-02-06 | 2005-08-25 | Bayer Healthcare Llc | Fluid testing sensor having vents for directing fluid flow |
EP1714148B1 (en) | 2004-02-06 | 2011-11-02 | Bayer HealthCare LLC | Electrochemical biosensor |
RU2006132051A (en) * | 2004-02-06 | 2008-03-20 | БАЙЕР ХЕЛТКЭР ЭлЭлСи (US) | OXIDIZABLE COMPOUNDS AS AN INTERNAL STANDARD FOR BIOSENSORS AND METHOD OF APPLICATION |
US8828203B2 (en) | 2004-05-20 | 2014-09-09 | Sanofi-Aventis Deutschland Gmbh | Printable hydrogels for biosensors |
WO2005120365A1 (en) | 2004-06-03 | 2005-12-22 | Pelikan Technologies, Inc. | Method and apparatus for a fluid sampling device |
US9775553B2 (en) | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
JP4805259B2 (en) * | 2004-06-17 | 2011-11-02 | バイエル・ヘルスケア・エルエルシー | Detection of incomplete filling of biosensor |
US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
CA2603542C (en) | 2005-04-08 | 2014-01-14 | Bayer Healthcare Llc | Oxidizable species as an internal reference in control solutions for biosensors |
US7695600B2 (en) * | 2005-06-03 | 2010-04-13 | Hypoguard Limited | Test system |
AR054851A1 (en) | 2005-07-20 | 2007-07-18 | Bayer Healthcare Llc | REGULATED AMPEROMETRY |
WO2007014231A1 (en) | 2005-07-26 | 2007-02-01 | Bayer Healthcare Llc | Method and system for checking an electromechanical biosensor |
KR100801905B1 (en) * | 2005-08-08 | 2008-02-12 | 주식회사 인포피아 | Method and apparatus for measuring results of samples on biosensor |
US8404100B2 (en) | 2005-09-30 | 2013-03-26 | Bayer Healthcare Llc | Gated voltammetry |
US7887682B2 (en) | 2006-03-29 | 2011-02-15 | Abbott Diabetes Care Inc. | Analyte sensors and methods of use |
US7636033B2 (en) | 2006-04-05 | 2009-12-22 | Larry Golden | Multi sensor detection, stall to stop and lock disabling system |
EP2008088B1 (en) | 2006-04-10 | 2011-06-29 | Bayer HealthCare LLC | Correction of oxygen effect in test sensor using reagents |
US8038859B2 (en) * | 2006-04-28 | 2011-10-18 | Hmd Biomedical Inc. | Electrochemical sensor and method for analyzing liquid sample |
WO2007133457A2 (en) * | 2006-05-08 | 2007-11-22 | Bayer Healthcare Llc | Electrochemical test sensor with reduced sample volume |
US7993512B2 (en) | 2006-07-11 | 2011-08-09 | Bayer Healthcare, Llc | Electrochemical test sensor |
US7797987B2 (en) * | 2006-10-11 | 2010-09-21 | Bayer Healthcare Llc | Test sensor with a side vent and method of making the same |
EP2083674B1 (en) | 2006-10-24 | 2018-03-07 | Ascensia Diabetes Care Holdings AG | Transient decay amperometry |
US20080133059A1 (en) * | 2006-12-05 | 2008-06-05 | Bayer Healthcare Llc | Table-driven test sequence |
US20090288964A1 (en) * | 2006-12-13 | 2009-11-26 | Sung-Kwon Jung | Biosensor with coded information and method for manufacturing the same |
US7802467B2 (en) | 2006-12-22 | 2010-09-28 | Abbott Diabetes Care Inc. | Analyte sensors and methods of use |
WO2008085251A1 (en) | 2007-01-05 | 2008-07-17 | Bayer Healthcare Llc | Electrochemical test sensor with light guide |
US7972866B2 (en) * | 2007-06-18 | 2011-07-05 | Nipro Diagnostics, Inc. | Biosensor and ultrasonic method of making a biosensor |
JP2010536035A (en) * | 2007-08-06 | 2010-11-25 | バイエル・ヘルスケア・エルエルシー | System and method for automatic calibration |
WO2009076302A1 (en) | 2007-12-10 | 2009-06-18 | Bayer Healthcare Llc | Control markers for auto-detection of control solution and methods of use |
WO2009076271A2 (en) * | 2007-12-10 | 2009-06-18 | Bayer Healthcare Llc | Wear-resistant electrochemical test sensor and method of forming the same |
US20090205399A1 (en) * | 2008-02-15 | 2009-08-20 | Bayer Healthcare, Llc | Auto-calibrating test sensors |
WO2009126900A1 (en) | 2008-04-11 | 2009-10-15 | Pelikan Technologies, Inc. | Method and apparatus for analyte detecting device |
US20100187132A1 (en) * | 2008-12-29 | 2010-07-29 | Don Alden | Determination of the real electrochemical surface areas of screen printed electrodes |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
US9378443B2 (en) * | 2009-05-14 | 2016-06-28 | Ascensia Diabetes Care Holding Ag | Calibration coded sensors and apparatus, systems and methods for reading same |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
WO2012064648A1 (en) | 2010-11-12 | 2012-05-18 | Bayer Healthcare Llc | Auto-coded analyte sensors and apparatus, systems, and methods for detecting same |
TWI493186B (en) * | 2013-02-08 | 2015-07-21 | Hmd Biomedical Inc | Test strip, detecting device and detection method |
KR101771829B1 (en) * | 2013-03-15 | 2017-08-25 | 에프. 호프만-라 로슈 아게 | Descriptor-based methods of electrochemically measuring an analyte as well as devices, apparatuses and systems incoporating the same |
GB201420982D0 (en) * | 2014-11-26 | 2015-01-07 | Inside Biometrics Ltd | Verifying operation of a meter |
KR20190091569A (en) | 2014-12-19 | 2019-08-06 | 에프. 호프만-라 로슈 아게 | Test element for electrochemically detecting at least one analyte |
Citations (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4172770A (en) | 1978-03-27 | 1979-10-30 | Technicon Instruments Corporation | Flow-through electrochemical system analytical method |
US4549952A (en) * | 1982-11-22 | 1985-10-29 | Eastman Kodak Company | Capillary transport device having means for increasing the viscosity of the transported liquid |
EP0429076A2 (en) | 1989-11-24 | 1991-05-29 | Matsushita Electric Industrial Co., Ltd. | Preparation of biosensor |
US5120420A (en) | 1988-03-31 | 1992-06-09 | Matsushita Electric Industrial Co., Ltd. | Biosensor and a process for preparation thereof |
US5141868A (en) | 1984-06-13 | 1992-08-25 | Internationale Octrooi Maatschappij "Octropa" Bv | Device for use in chemical test procedures |
EP0502504A1 (en) | 1991-03-04 | 1992-09-09 | Matsushita Electric Industrial Co., Ltd. | A biosensor utilizing enzyme and a method for producing the same |
US5192415A (en) | 1991-03-04 | 1993-03-09 | Matsushita Electric Industrial Co., Ltd. | Biosensor utilizing enzyme and a method for producing the same |
EP0537761A2 (en) | 1991-10-18 | 1993-04-21 | Matsushita Electric Industrial Co., Ltd. | A biosensor and a method for measuring a concentration of a substrate in a sample |
JPH05502727A (en) | 1989-12-15 | 1993-05-13 | ベーリンガー マンハイム コーポレーション | Biosensor system and method used therein |
JPH06109688A (en) | 1992-09-25 | 1994-04-22 | Matsushita Electric Ind Co Ltd | Liquid constituent measuring device |
US5352351A (en) | 1993-06-08 | 1994-10-04 | Boehringer Mannheim Corporation | Biosensing meter with fail/safe procedures to prevent erroneous indications |
EP0636879A2 (en) | 1993-07-23 | 1995-02-01 | Matsushita Electric Industrial Co., Ltd. | Biosensor and method for producing the same |
EP0679720A1 (en) | 1994-04-25 | 1995-11-02 | Matsushita Electric Industrial Co., Ltd. | Method for quantifying specific compound |
US5512159A (en) | 1992-01-21 | 1996-04-30 | Matsushita Electric Industrial Co. Ltd. | Biosensor |
GB2296332A (en) | 1994-12-22 | 1996-06-26 | Draegerwerk Ag | Method for identifying causes of faults in amperometric measuring cells |
EP0732406A1 (en) | 1995-03-17 | 1996-09-18 | Matsushita Electric Industrial Co., Ltd. | A method and a device for quantifying a substrate in a sample liquid using a biosensor |
US5575403A (en) | 1995-01-13 | 1996-11-19 | Bayer Corporation | Dispensing instrument for fluid monitoring sensors |
JPH08304340A (en) | 1995-05-05 | 1996-11-22 | Bayer Corp | Method and device for measuring concentration of analysis object by utilizing amperometric sensor |
JPH08320304A (en) | 1995-03-17 | 1996-12-03 | Matsushita Electric Ind Co Ltd | Biosensor as well as method and apparatus for determination using it |
US5628890A (en) | 1995-09-27 | 1997-05-13 | Medisense, Inc. | Electrochemical sensor |
EP0795748A1 (en) | 1996-03-12 | 1997-09-17 | Matsushita Electric Industrial Co., Ltd. | Biosensor and method for quantitating biochemical substrate using the same |
EP0795601A2 (en) | 1996-03-13 | 1997-09-17 | Matsushita Electric Industrial Co., Ltd. | Biosensor |
EP0800080A2 (en) | 1996-04-04 | 1997-10-08 | Matsushita Electric Industrial Co., Ltd. | Method for quantifying substrate using an enzyme electrode |
US5759364A (en) | 1997-05-02 | 1998-06-02 | Bayer Corporation | Electrochemical biosensor |
EP0851224A1 (en) | 1996-12-24 | 1998-07-01 | Matsushita Electric Industrial Co., Ltd. | Biosensor with C-shaped counter electrode |
US5786584A (en) | 1995-09-06 | 1998-07-28 | Eli Lilly And Company | Vial and cartridge reading device providing audio feedback for a blood glucose monitoring system |
US5798031A (en) | 1997-05-12 | 1998-08-25 | Bayer Corporation | Electrochemical biosensor |
EP0872728A1 (en) | 1997-04-14 | 1998-10-21 | Matsushita Electric Industrial Co., Ltd. | Biosensor with divalent metallic salt |
EP0909952A2 (en) | 1997-09-29 | 1999-04-21 | Matsushita Electric Industrial Co., Ltd. | Biosensor and method for quantitative measurement of a substrate using the same |
DE19747875A1 (en) | 1997-10-20 | 1999-05-06 | Meinhard Prof Dr Knoll | Method for measuring variable sizes and device for carrying out the method |
JP2960265B2 (en) | 1991-10-18 | 1999-10-06 | 松下電器産業株式会社 | Biosensor and measurement method using the same |
WO1999060391A1 (en) | 1998-05-20 | 1999-11-25 | Arkray, Inc. | Method and apparatus for electrochemical measurement using statistical technique |
EP0987544A1 (en) | 1998-04-02 | 2000-03-22 | Matsushita Electric Industrial Co., Ltd. | Substrate determining method |
US6153069A (en) | 1995-02-09 | 2000-11-28 | Tall Oak Ventures | Apparatus for amperometric Diagnostic analysis |
EP1074335A2 (en) | 1999-07-08 | 2001-02-07 | Meltog Limited | Mandrel and tooling replacement and apparatus therefor |
EP1074832A1 (en) | 1999-08-02 | 2001-02-07 | Bayer Corporation | Improved electrochemical-sensor design |
WO2001067099A1 (en) | 2000-03-08 | 2001-09-13 | Inverness Medical Limited | Measurement of substances in liquids |
JP2003004691A (en) | 2001-05-21 | 2003-01-08 | Bayer Corp | Improved electrochemical sensor |
JP2003014684A (en) | 2001-06-28 | 2003-01-15 | Matsushita Electric Ind Co Ltd | Biosensor and its measurement sensitivity controlling method |
US6518034B1 (en) | 1998-06-25 | 2003-02-11 | Abb Diagnostics, Ltd. | Test strip for blood glucose determination |
CA2419213A1 (en) | 2002-03-07 | 2003-09-07 | Bayer Healthcare, Llc | Improved electrical sensor |
US6814844B2 (en) | 2001-08-29 | 2004-11-09 | Roche Diagnostics Corporation | Biosensor with code pattern |
US6841052B2 (en) * | 1999-08-02 | 2005-01-11 | Bayer Corporation | Electrochemical-sensor design |
US20070045127A1 (en) | 2004-02-06 | 2007-03-01 | Dijia Huang | Electrochemical biosensor |
-
2001
- 2001-05-21 US US09/861,437 patent/US6841052B2/en not_active Expired - Lifetime
-
2004
- 2004-06-09 US US10/864,011 patent/US7125481B2/en not_active Ceased
-
2008
- 2008-10-23 US US12/257,031 patent/USRE44521E1/en not_active Expired - Fee Related
-
2013
- 2013-09-09 US US14/022,189 patent/USRE45384E1/en not_active Expired - Fee Related
Patent Citations (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4172770A (en) | 1978-03-27 | 1979-10-30 | Technicon Instruments Corporation | Flow-through electrochemical system analytical method |
US4549952A (en) * | 1982-11-22 | 1985-10-29 | Eastman Kodak Company | Capillary transport device having means for increasing the viscosity of the transported liquid |
US5141868A (en) | 1984-06-13 | 1992-08-25 | Internationale Octrooi Maatschappij "Octropa" Bv | Device for use in chemical test procedures |
US5120420A (en) | 1988-03-31 | 1992-06-09 | Matsushita Electric Industrial Co., Ltd. | Biosensor and a process for preparation thereof |
US5120420B1 (en) | 1988-03-31 | 1999-11-09 | Matsushita Electric Ind Co Ltd | Biosensor and a process for preparation thereof |
EP0429076A2 (en) | 1989-11-24 | 1991-05-29 | Matsushita Electric Industrial Co., Ltd. | Preparation of biosensor |
JPH05502727A (en) | 1989-12-15 | 1993-05-13 | ベーリンガー マンハイム コーポレーション | Biosensor system and method used therein |
US5192415A (en) | 1991-03-04 | 1993-03-09 | Matsushita Electric Industrial Co., Ltd. | Biosensor utilizing enzyme and a method for producing the same |
EP0502504A1 (en) | 1991-03-04 | 1992-09-09 | Matsushita Electric Industrial Co., Ltd. | A biosensor utilizing enzyme and a method for producing the same |
EP0537761A2 (en) | 1991-10-18 | 1993-04-21 | Matsushita Electric Industrial Co., Ltd. | A biosensor and a method for measuring a concentration of a substrate in a sample |
US5264103A (en) | 1991-10-18 | 1993-11-23 | Matsushita Electric Industrial Co., Ltd. | Biosensor and a method for measuring a concentration of a substrate in a sample |
JP2960265B2 (en) | 1991-10-18 | 1999-10-06 | 松下電器産業株式会社 | Biosensor and measurement method using the same |
EP0735363A1 (en) | 1991-10-18 | 1996-10-02 | Matsushita Electric Industrial Co., Ltd. | A biosensor and a method for measuring a concentration of a substrate in a sample |
US5512159A (en) | 1992-01-21 | 1996-04-30 | Matsushita Electric Industrial Co. Ltd. | Biosensor |
JPH06109688A (en) | 1992-09-25 | 1994-04-22 | Matsushita Electric Ind Co Ltd | Liquid constituent measuring device |
US5352351A (en) | 1993-06-08 | 1994-10-04 | Boehringer Mannheim Corporation | Biosensing meter with fail/safe procedures to prevent erroneous indications |
JPH08502589A (en) | 1993-06-08 | 1996-03-19 | ベーリンガー マンハイム コーポレーション | Bio-sensing meter with fail-safe function to prevent false display |
EP0636879A2 (en) | 1993-07-23 | 1995-02-01 | Matsushita Electric Industrial Co., Ltd. | Biosensor and method for producing the same |
EP0679720A1 (en) | 1994-04-25 | 1995-11-02 | Matsushita Electric Industrial Co., Ltd. | Method for quantifying specific compound |
GB2296332A (en) | 1994-12-22 | 1996-06-26 | Draegerwerk Ag | Method for identifying causes of faults in amperometric measuring cells |
US5575403A (en) | 1995-01-13 | 1996-11-19 | Bayer Corporation | Dispensing instrument for fluid monitoring sensors |
US6153069A (en) | 1995-02-09 | 2000-11-28 | Tall Oak Ventures | Apparatus for amperometric Diagnostic analysis |
JPH08320304A (en) | 1995-03-17 | 1996-12-03 | Matsushita Electric Ind Co Ltd | Biosensor as well as method and apparatus for determination using it |
US5582697A (en) | 1995-03-17 | 1996-12-10 | Matsushita Electric Industrial Co., Ltd. | Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same |
EP0732406A1 (en) | 1995-03-17 | 1996-09-18 | Matsushita Electric Industrial Co., Ltd. | A method and a device for quantifying a substrate in a sample liquid using a biosensor |
US5620579A (en) | 1995-05-05 | 1997-04-15 | Bayer Corporation | Apparatus for reduction of bias in amperometric sensors |
US5653863A (en) | 1995-05-05 | 1997-08-05 | Bayer Corporation | Method for reducing bias in amperometric sensors |
JPH08304340A (en) | 1995-05-05 | 1996-11-22 | Bayer Corp | Method and device for measuring concentration of analysis object by utilizing amperometric sensor |
US5786584A (en) | 1995-09-06 | 1998-07-28 | Eli Lilly And Company | Vial and cartridge reading device providing audio feedback for a blood glucose monitoring system |
JPH09222411A (en) | 1995-09-27 | 1997-08-26 | Medisense Inc | Electrochemical sensor |
US5628890A (en) | 1995-09-27 | 1997-05-13 | Medisense, Inc. | Electrochemical sensor |
EP0795748A1 (en) | 1996-03-12 | 1997-09-17 | Matsushita Electric Industrial Co., Ltd. | Biosensor and method for quantitating biochemical substrate using the same |
EP0795601A2 (en) | 1996-03-13 | 1997-09-17 | Matsushita Electric Industrial Co., Ltd. | Biosensor |
EP0800080A2 (en) | 1996-04-04 | 1997-10-08 | Matsushita Electric Industrial Co., Ltd. | Method for quantifying substrate using an enzyme electrode |
EP0851224A1 (en) | 1996-12-24 | 1998-07-01 | Matsushita Electric Industrial Co., Ltd. | Biosensor with C-shaped counter electrode |
EP0851224B1 (en) | 1996-12-24 | 2002-03-27 | Matsushita Electric Industrial Co., Ltd. | Biosensor with C-shaped counter electrode |
EP0872728A1 (en) | 1997-04-14 | 1998-10-21 | Matsushita Electric Industrial Co., Ltd. | Biosensor with divalent metallic salt |
US5759364A (en) | 1997-05-02 | 1998-06-02 | Bayer Corporation | Electrochemical biosensor |
JPH10318970A (en) | 1997-05-02 | 1998-12-04 | Bayer Corp | Electrochemical biosensor |
EP0877244A1 (en) | 1997-05-02 | 1998-11-11 | Bayer Corporation | Electrochemical biosensor |
US5798031A (en) | 1997-05-12 | 1998-08-25 | Bayer Corporation | Electrochemical biosensor |
EP0909952A2 (en) | 1997-09-29 | 1999-04-21 | Matsushita Electric Industrial Co., Ltd. | Biosensor and method for quantitative measurement of a substrate using the same |
DE19747875A1 (en) | 1997-10-20 | 1999-05-06 | Meinhard Prof Dr Knoll | Method for measuring variable sizes and device for carrying out the method |
EP0987544A1 (en) | 1998-04-02 | 2000-03-22 | Matsushita Electric Industrial Co., Ltd. | Substrate determining method |
WO1999060391A1 (en) | 1998-05-20 | 1999-11-25 | Arkray, Inc. | Method and apparatus for electrochemical measurement using statistical technique |
EP1081490A1 (en) | 1998-05-20 | 2001-03-07 | ARKRAY, Inc. | Method and apparatus for electrochemical measurement using statistical technique |
US6518034B1 (en) | 1998-06-25 | 2003-02-11 | Abb Diagnostics, Ltd. | Test strip for blood glucose determination |
EP1074335A2 (en) | 1999-07-08 | 2001-02-07 | Meltog Limited | Mandrel and tooling replacement and apparatus therefor |
US7125481B2 (en) | 1999-08-02 | 2006-10-24 | Bayer Healthcare Llc | Electrochemical-sensor design |
US6841052B2 (en) * | 1999-08-02 | 2005-01-11 | Bayer Corporation | Electrochemical-sensor design |
USRE44521E1 (en) * | 1999-08-02 | 2013-10-08 | Bayer Healthcare Llc | Electrochemical-sensor design |
EP1074832A1 (en) | 1999-08-02 | 2001-02-07 | Bayer Corporation | Improved electrochemical-sensor design |
JP2001066279A (en) | 1999-08-02 | 2001-03-16 | Bayer Corp | Improved electrochemical sensor design |
US6531040B2 (en) * | 1999-08-02 | 2003-03-11 | Bayer Corporation | Electrochemical-sensor design |
WO2001067099A1 (en) | 2000-03-08 | 2001-09-13 | Inverness Medical Limited | Measurement of substances in liquids |
US7122110B2 (en) | 2001-05-21 | 2006-10-17 | Bayer Healthcare Llc | Electrochemical test sensor |
JP2003004691A (en) | 2001-05-21 | 2003-01-08 | Bayer Corp | Improved electrochemical sensor |
JP2003014684A (en) | 2001-06-28 | 2003-01-15 | Matsushita Electric Ind Co Ltd | Biosensor and its measurement sensitivity controlling method |
US6814844B2 (en) | 2001-08-29 | 2004-11-09 | Roche Diagnostics Corporation | Biosensor with code pattern |
US7118668B1 (en) | 2002-03-07 | 2006-10-10 | Bayer Healthcare Llc | Electrochemical test sensor |
CA2419213A1 (en) | 2002-03-07 | 2003-09-07 | Bayer Healthcare, Llc | Improved electrical sensor |
US20070045127A1 (en) | 2004-02-06 | 2007-03-01 | Dijia Huang | Electrochemical biosensor |
EP1714148B1 (en) | 2004-02-06 | 2011-11-02 | Bayer HealthCare LLC | Electrochemical biosensor |
JP4814110B2 (en) | 2004-02-06 | 2011-11-16 | バイエル・ヘルスケア・エルエルシー | Electrochemical biosensor |
Non-Patent Citations (6)
Title |
---|
Extended European Search Report for European Application No. 10 18 3635 dated Dec. 23, 2010 (6 pages). |
Interlocutory decision in Oral Proceedings (Art. 101(3)(a) and 106(2) EPC) to European Patent EP 1 074 832 B1 dated Feb. 28, 2013, 42 pages. |
Letter from Opposer Concerning the Summons to Attend Oral Proceedings to Rule 115(1) EPC to European Patent EP 1 074 832 B1 dated Dec. 27, 2012, 48 pages. |
Notice of Opposition to European Patent EP 1 074 832 B1 dated Jun. 24, 2010, 30 pages. |
Response to Opposition to European Patent EP 1 074 832 B1 filed with European Patent Office on Jan. 25, 2011, 12 pages. |
Summons to Attend Oral Proceedings Pursuant to Rule 115(1) EPC to European Patent EP 1 074 832 B1 dated Sep. 3, 2012, 12 pages. |
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US20040200720A1 (en) | 2004-10-14 |
US7125481B2 (en) | 2006-10-24 |
US6841052B2 (en) | 2005-01-11 |
USRE44521E1 (en) | 2013-10-08 |
US20040222092A1 (en) | 2004-11-11 |
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