Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.

Patents

  1. Advanced Patent Search
Publication numberUSD665095 S1
Publication typeGrant
Application numberUS 29/389,681
Publication date7 Aug 2012
Filing date14 Apr 2011
Priority date11 Jul 2008
Also published asUSD618820, USD637737
Publication number29389681, 389681, US D665095 S1, US D665095S1, US-S1-D665095, USD665095 S1, USD665095S1
InventorsKerry Wilson, Kalyan Handique, Jeff Williams, Sundaresh N. Brahmasandra
Original AssigneeHandylab, Inc.
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Reagent holder
US D665095 S1
Abstract  available in
Images(4)
Previous page
Next page
Claims(1)
  1. The ornamental design for a reagent holder, substantially as shown and described.
Description

FIG. 1 is a perspective view of a reagent holder showing our new design;

FIG. 2 is a first side plan view thereof;

FIG. 3 is a second side plan view thereof with the second side plan view being a mirror image of the first side plan view shown in FIG. 2;

FIG. 4 is a first end view thereof;

FIG. 5 is a second end view thereof;

FIG. 6 is a top plan thereof; and,

FIG. 7 is a bottom plan view thereof.

The broken lines where present in FIGS. 1 through 7 are for illustrative purposes only and identify portions of the reagent holder that form no part of the claimed design.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US14343144 Aug 192131 Oct 1922Anthony RaichLunch pail
US16164193 Apr 19251 Feb 1927Everlasting Valve CompanyAutomatic shut-off device for gas in case of fire
US173340129 Mar 192829 Oct 1929Matthias ChristmanJournal box
US352844927 Feb 196815 Sep 1970Trw IncFluid flow control apparatus
US398564925 Nov 197412 Oct 1976Eddelman Roy TFerromagnetic separation process and material
US40180895 May 197619 Apr 1977Beckman Instruments, Inc.Fluid sampling apparatus
US40186529 Jan 197619 Apr 1977Mcdonnell Douglas CorporationProcess and apparatus for ascertaining the concentration of microorganism in a water specimen
US403819214 Jul 197526 Jul 1977International Biomedical Laboratories, Inc.Device for exchange between fluids suitable for treatment of blood
US405539529 Oct 197625 Oct 1977Hitachi, Ltd.Analysis apparatus
US41390051 Sep 197713 Feb 1979Dickey Gilbert CSafety release pipe cap
US421274414 Jun 197815 Jul 1980Asahi Medical Co., Ltd.Haemodialyzer apparatus
US430141229 Oct 197917 Nov 1981United States Surgical CorporationLiquid conductivity measuring system and sample cards therefor
US443952626 Jul 198227 Mar 1984Eastman Kodak CompanyClustered ingress apertures for capillary transport devices and method of use
US44573294 Dec 19813 Jul 1984Air Products And Chemicals, Inc.Safety pressure regulator
US44667407 Oct 198121 Aug 1984Olympus Optical Co., Ltd.Particle agglutination analyzing plate
US45045827 Feb 198312 Mar 1985Genex CorporationVermiculite as a carrier support for immobilized biological materials
US452278610 Aug 198311 Jun 1985E. I. Du Pont De Nemours And CompanyMultilayered test device for detecting analytes in liquid test samples
US459931513 Sep 19838 Jul 1986University Of California RegentsMicrodroplet test apparatus
US46128732 Sep 198323 Sep 1986Firma Andreas HettichCentrifuge chamber for cytodiagnostic investigation of epithelial cells contained in a sample
US46129597 May 198523 Sep 1986Mobil Oil CorporationValveless shut-off and transfer device
US465412727 Nov 198531 Mar 1987Sentech Medical CorporationSelf-calibrating single-use sensing device for clinical chemistry and method of use
US46736571 Jun 198416 Jun 1987The Regents Of The University Of CaliforniaMultiple assay card and system
US46831957 Feb 198628 Jul 1987Cetus CorporationProcess for amplifying, detecting, and/or-cloning nucleic acid sequences
US468320225 Oct 198527 Nov 1990Cetus CorpTitle not available
US472037422 Jul 198519 Jan 1988E. I. Du Pont De Nemours And CompanyContainer having a sonication compartment
US47986933 Aug 198717 Jan 1989Ngk Insulators, Ltd.Method of manufacturing an electrochemical device
US48000224 Nov 198624 Jan 1989Baxter International Inc.Platelet collection system
US48417866 Jun 198827 Jun 1989Forschungs-& Entwicklungs-KgSpecimen distributing system
US489565025 Feb 198823 Jan 1990Gen-Probe IncorporatedMagnetic separation rack for diagnostic assays
US491982930 Dec 198824 Apr 1990The United States Of America As Represented By The Secretary Of CommerceAluminum hydroxides as solid lubricants
US492180929 Sep 19871 May 1990Findley Adhesives, Inc.Polymer coated solid matrices and use in immunoassays
US49353421 Dec 198619 Jun 1990Syngene, Inc.Method of isolating and purifying nucleic acids from biological samples
US49465624 Aug 19887 Aug 1990Medtest Systems, Inc.Apparatus and methods for sensing fluid components
US494974226 Apr 198921 Aug 1990Spectra-Physics, Inc.Temperature operated gas valve
US496349815 Jan 198816 Oct 1990BiotrackCapillary flow device
US496795031 Oct 19896 Nov 1990International Business Machines CorporationSoldering method
US497850215 Dec 198718 Dec 1990Dole Associates, Inc.Immunoassay or diagnostic device and method of manufacture
US49786221 Sep 198918 Dec 1990Regents Of The University Of CaliforniaCytophaga-derived immunopotentiator
US49896268 Nov 19895 Feb 1991Hitachi, Ltd.Apparatus for and method of controlling the opening and closing of channel for liquid
US500141725 May 198819 Mar 1991Abbott LaboratoriesApparatus for measuring electrolytes utilizing optical signals related to the concentration of the electrolytes
US50045838 Aug 19882 Apr 1991Medtest Systems, Inc.Universal sensor cartridge for use with a universal analyzer for sensing components in a multicomponent fluid
US504855424 Sep 199017 Sep 1991Ceodeux S.A.Valve for a gas cylinder
US505319921 Feb 19891 Oct 1991Boehringer Mannheim CorporationElectronically readable information carrier
US506082315 Sep 198829 Oct 1991Brandeis UniversitySterile transfer system
US50613361 May 198929 Oct 1991Soane Technologies, Inc.Gel casting method and apparatus
US506461826 Aug 198812 Nov 1991Thorn Emi PlcSensor arrangements
US50715311 May 198910 Dec 1991Soane Technologies, Inc.Casting of gradient gels
US509132821 Nov 198925 Feb 1992National Semiconductor CorporationMethod of late programming MOS devices
US509666915 Sep 198817 Mar 1992I-Stat CorporationDisposable sensing device for real time fluid analysis
US512600225 Sep 199030 Jun 1992Glory Kogyo Kabushiki KaishaLeaf paper bundling apparatus
US512602228 Feb 199030 Jun 1992Soane Tecnologies, Inc.Method and device for moving molecules by the application of a plurality of electrical fields
US513562715 Oct 19904 Aug 1992Soane Technologies, Inc.Mosaic microcolumns, slabs, and separation media for electrophoresis and chromatography
US513587228 Apr 19894 Aug 1992Sangstat Medical CorporationMatrix controlled method of delayed fluid delivery for assays
US51476066 Aug 199015 Sep 1992Miles Inc.Self-metering fluid analysis device
US516951221 Mar 19898 Dec 1992Robert Bosch GmbhPlanar polarographic probe for determining the λ value of gas mixtures
US518633918 Jul 199116 Feb 1993Eastman Kodak CompanyDevice comprising a plurality of receptacles arranged in a single row for containers filled with a liquid
US51925074 Mar 19919 Mar 1993Arthur D. Little, Inc.Receptor-based biosensors
US52081636 Dec 19914 May 1993Miles Inc.Self-metering fluid analysis device
US522322614 Apr 199229 Jun 1993Millipore CorporationInsulated needle for forming an electrospray
US525026330 Oct 19915 Oct 1993Ciba-Geigy CorporationApparatus for processing or preparing liquid samples for chemical analysis
US525274313 Nov 199012 Oct 1993Affymax Technologies N.V.Spatially-addressable immobilization of anti-ligands on surfaces
US525637612 Sep 199126 Oct 1993Medical Laboratory Automation, Inc.Agglutination detection apparatus
US527578717 Aug 19924 Jan 1994Canon Kabushiki KaishaApparatus for separating or measuring particles to be examined in a sample fluid
US528295014 Jul 19921 Feb 1994Boehringer Mannheim GmbhElectrochemical analysis system
US52963751 May 199222 Mar 1994Trustees Of The University Of PennsylvaniaMesoscale sperm handling devices
US53044772 Jul 199219 Apr 1994Fuji Oil Company, LimitedProcess for producing hard fats using 1,3-specific lipase and mixture of palmitic, lauric and behemic acids
US53044871 May 199219 Apr 1994Trustees Of The University Of PennsylvaniaFluid handling in mesoscale analytical devices
US531189610 Apr 199017 May 1994Niilo KaartinenMethod for producing a heatable and refrigerable element for a system handling small quantities of liquid, and an element manufactured by the method
US53119965 Jan 199317 May 1994Duffy Thomas JEdge protector
US531672728 Aug 199231 May 1994Terumo Kabushiki KaishaMeasuring apparatus
US532703816 Dec 19915 Jul 1994Rockwell International CorporationWalking expansion actuator
US533948610 Mar 199323 Aug 1994Persic Jr William VGolf ball cleaner
US53645911 Jun 199215 Nov 1994Eastman Kodak CompanyDevice for moving a target-bearing solid through a liquid for detection while being contained
US53729466 Jan 199413 Dec 1994International Technidyne CorporationBlood coagulation time test apparatus and method
US537439514 Oct 199320 Dec 1994Amoco CorporationDiagnostics instrument
US538933919 Aug 199214 Feb 1995Enprotech CorporationIntegral biomolecule preparation device
US539770927 Aug 199314 Mar 1995Becton Dickinson And CompanySystem for detecting bacterial growth in a plurality of culture vials
US54014655 May 199228 Mar 1995Chiron CorporationLuminometer with reduced sample crosstalk
US54117085 Aug 19922 May 1995Moscetta; PompeoApparatus for the determination of analytes in liquid samples
US54142453 Aug 19929 May 1995Hewlett-Packard CorporationThermal-ink heater array using rectifying material
US541600021 Nov 199116 May 1995Chemtrak, Inc.Analyte immunoassay in self-contained apparatus
US542227120 Nov 19926 Jun 1995Eastman Kodak CompanyNucleic acid material amplification and detection without washing
US542228429 Oct 19936 Jun 1995E. I. Du Pont De Nemours And CompanyMethod of performing affinity separation using immobilized flocculating agent on chromatographic support
US542794621 Jan 199427 Jun 1995Trustees Of The University Of PennsylvaniaMesoscale sperm handling devices
US547479627 May 199312 Dec 1995Protogene Laboratories, Inc.Method and apparatus for conducting an array of chemical reactions on a support surface
US548633524 Apr 199523 Jan 1996Trustees Of The University Of PennsylvaniaAnalysis based on flow restriction
US549463913 Oct 199427 Feb 1996Behringwerke AktiengesellschaftBiosensor for measuring changes in viscosity and/or density of a fluid
US549839219 Sep 199412 Mar 1996Trustees Of The University Of PennsylvaniaMesoscale polynucleotide amplification device and method
US55038039 Aug 19942 Apr 1996Conception Technologies, Inc.Miniaturized biological assembly
US55164109 Dec 199414 May 1996Robert Bosch GmbhPlanar sensor element having a solid electrolyte substrate
US55196356 Sep 199421 May 1996Hitachi Ltd.Apparatus for chemical analysis with detachable analytical units
US552967711 Sep 199325 Jun 1996Robert Bosch GmbhPlanar polarographic sensor for determining the lambda value of gas mixtures
US555943229 Jun 199424 Sep 1996Logue; Delmar L.Joystick generating a polar coordinates signal utilizing a rotating magnetic field within a hollow toroid core
US556517110 May 199515 Oct 1996Governors Of The University Of AlbertaContinuous biochemical reactor for analysis of sub-picomole quantities of complex organic molecules
US556936410 May 199429 Oct 1996Soane Biosciences, Inc.Separation media for electrophoresis
US557881810 May 199526 Nov 1996Molecular DynamicsLED point scanning system
US55799286 Mar 19953 Dec 1996Anukwuem; Chidi I.Test tube holder with lock down clamp
US55805231 Apr 19943 Dec 1996Bard; Allen J.Integrated chemical synthesizers
US558288429 Sep 199210 Dec 1996Alcan International LimitedPeelable laminated structures and process for production thereof
US558506910 Nov 199417 Dec 1996David Sarnoff Research Center, Inc.Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US55850897 Jun 199517 Dec 1996Protein Design Labs, Inc.Humanized immunoglobulins
US558524231 Aug 199517 Dec 1996Abbott LaboratoriesMethod for detection of nucleic acid using total internal reflectance
US558712814 Nov 199424 Dec 1996The Trustees Of The University Of PennsylvaniaMesoscale polynucleotide amplification devices
US558913620 Jun 199531 Dec 1996Regents Of The University Of CaliforniaSilicon-based sleeve devices for chemical reactions
US559383831 May 199514 Jan 1997David Sarnoff Research Center, Inc.Partitioned microelectronic device array
US559570818 Nov 199421 Jan 1997Becton Dickinson And CompanySystem for detecting bacterial growth in a plurality of culture vials
US55994328 Nov 19944 Feb 1997Ciba-Geigy CorporationDevice and a method for the electrophoretic separation of fluid substance mixtures
US559950322 Nov 19914 Feb 1997Ciba-Geigy CorporationDetector cell
US559966723 Sep 19944 Feb 1997Gen-Probe IncorporatedPolycationic supports and nucleic acid purification separation and hybridization
US56017273 Nov 199211 Feb 1997Pall CorporationDevice and method for separating plasma from a biological fluid
US56033517 Jun 199518 Feb 1997David Sarnoff Research Center, Inc.Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
US56056621 Nov 199325 Feb 1997Nanogen, Inc.Active programmable electronic devices for molecular biological analysis and diagnostics
US562889027 Sep 199513 May 1997Medisense, Inc.Electrochemical sensor
US563092028 Feb 199520 May 1997Robert Bosch GmbhElectrochemical sensor for determining the oxygen concentration in gas mixtures
US563133719 Jan 199620 May 1997Soane BioscienceThermoreversible hydrogels comprising linear copolymers and their use in electrophoresis
US56328766 Jun 199527 May 1997David Sarnoff Research Center, Inc.Apparatus and methods for controlling fluid flow in microchannels
US56329579 Sep 199427 May 1997NanogenMolecular biological diagnostic systems including electrodes
US563535814 Feb 19943 Jun 1997Trustees Of The University Of PennsylvaniaFluid handling methods for use in mesoscale analytical devices
US563746930 Nov 199410 Jun 1997Trustees Of The University Of PennsylvaniaMethods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US563942331 Aug 199217 Jun 1997The Regents Of The University Of CalforniaMicrofabricated reactor
US564373831 May 19951 Jul 1997David Sarnoff Research Center, Inc.Method of synthesis of plurality of compounds in parallel using a partitioned solid support
US56460396 Jun 19958 Jul 1997The Regents Of The University Of CaliforniaMicrofabricated reactor
US564799420 Jun 199415 Jul 1997Labsystems OyMethod and apparatus for separating magnetic particles from a solution
US565183926 Oct 199529 Jul 1997Queen's University At KingstonProcess for engineering coherent twin and coincident site lattice grain boundaries in polycrystalline materials
US56521496 Mar 199529 Jul 1997Westinghouse Electric CorporationMixing apparatus & method for an optical agglutination assay device
US566797614 Feb 199616 Sep 1997Becton Dickinson And CompanySolid supports for nucleic acid hybridization assays
US567130317 Apr 199623 Sep 1997Motorola, Inc.Molecular detection apparatus and method using optical waveguide detection
US567439424 Mar 19957 Oct 1997Johnson & Johnson Medical, Inc.Single use system for preparation of autologous plasma
US56747426 Jun 19957 Oct 1997The Regents Of The University Of CaliforniaMicrofabricated reactor
US568148431 May 199528 Oct 1997David Sarnoff Research Center, Inc.Etching to form cross-over, non-intersecting channel networks for use in partitioned microelectronic and fluidic device arrays for clinical diagnostics and chemical synthesis
US568152923 Aug 199528 Oct 1997Nihon Medi-Physics Co., Ltd.Biological fluid analyzing device
US56836575 Jun 19954 Nov 1997Gamera Bioscience, Corp.DNA meltometer
US569915716 Jul 199616 Dec 1997Caliper Technologies Corp.Fourier detection of species migrating in a microchannel
US570063719 Apr 199423 Dec 1997Isis Innovation LimitedApparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US57058131 Nov 19956 Jan 1998Hewlett-Packard CompanyIntegrated planar liquid handling system for maldi-TOF MS
US572602614 Nov 199410 Mar 1998Trustees Of The University Of PennsylvaniaMesoscale sample preparation device and systems for determination and processing of analytes
US572640431 May 199610 Mar 1998University Of WashingtonValveless liquid microswitch
US57269445 Feb 199610 Mar 1998Motorola, Inc.Voltage regulator for regulating an output voltage from a charge pump and method therefor
US573121220 Dec 199424 Mar 1998International Technidyne CorporationTest apparatus and method for testing cuvette accommodated samples
US574436614 Nov 199428 Apr 1998Trustees Of The University Of PennsylvaniaMesoscale devices and methods for analysis of motile cells
US574766626 Mar 19975 May 1998Willis; John P.Point-of-care analyzer module
US575001513 Mar 199612 May 1998Soane BiosciencesMethod and device for moving molecules by the application of a plurality of electrical fields
US575594229 Aug 199626 May 1998David Sarnoff Research Center, Inc.Partitioned microelectronic device array
US57632623 Apr 19929 Jun 1998Quidel CorporationImmunodiagnostic device
US577002930 Jul 199623 Jun 1998Soane BiosciencesIntegrated electrophoretic microdevices
US577038813 Dec 199323 Jun 1998Dade Behring Marburg GmbhMethod of separation employing magnetic particles and second medium
US577296624 Jan 199730 Jun 1998Maracas; George N.Assay dispensing apparatus
US577986828 Jun 199614 Jul 1998Caliper Technologies CorporationElectropipettor and compensation means for electrophoretic bias
US578703210 Jun 199428 Jul 1998NanogenDeoxyribonucleic acid(DNA) optical storage using non-radiative energy transfer between a donor group, an acceptor group and a quencher group
US57888149 Apr 19964 Aug 1998David Sarnoff Research CenterChucks and methods for positioning multiple objects on a substrate
US58006903 Jul 19961 Sep 1998Caliper Technologies CorporationVariable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
US58044362 Aug 19968 Sep 1998Axiom Biotechnologies, Inc.Apparatus and method for real-time measurement of cellular response
US582748131 Jul 199727 Oct 1998Hewlett-Packard CompanyCartridge system for effecting sample acquisition and introduction
US58421069 Nov 199524 Nov 1998Sarnoff CorporationMethod of producing micro-electrical conduits
US58427879 Oct 19971 Dec 1998Caliper Technologies CorporationMicrofluidic systems incorporating varied channel dimensions
US58463969 Nov 19958 Dec 1998Sarnoff CorporationLiquid distribution system
US58492087 Sep 199515 Dec 1998Microfab Technoologies, Inc.Making apparatus for conducting biochemical analyses
US584948627 Sep 199515 Dec 1998Nanogen, Inc.Methods for hybridization analysis utilizing electrically controlled hybridization
US584948923 Aug 199615 Dec 1998Nanogen, Inc.Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system
US584959815 Mar 199615 Dec 1998Washington UniversityMethod for transferring micro quantities of liquid samples to discrete locations
US585249530 Sep 199722 Dec 1998Caliper Technologies CorporationFourier detection of species migrating in a microchannel
US585617419 Jan 19965 Jan 1999Affymetrix, Inc.Integrated nucleic acid diagnostic device
US585818726 Sep 199612 Jan 1999Lockheed Martin Energy Systems, Inc.Apparatus and method for performing electrodynamic focusing on a microchip
US58581884 Apr 199612 Jan 1999Aclara Biosciences, Inc.Acrylic microchannels and their use in electrophoretic applications
US586350223 Jan 199726 Jan 1999Sarnoff CorporationParallel reaction cassette and associated devices
US586370827 Jan 199726 Jan 1999Sarnoff CorporationPartitioned microelectronic device array
US586380114 Jun 199626 Jan 1999Sarnoff CorporationAutomated nucleic acid isolation
US58663455 Mar 19972 Feb 1999The Trustees Of The University Of PennsylvaniaApparatus for the detection of an analyte utilizing mesoscale flow systems
US58690049 Jun 19979 Feb 1999Caliper Technologies Corp.Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems
US58720103 Jul 199616 Feb 1999Northeastern UniversityMicroscale fluid handling system
US587262326 Sep 199616 Feb 1999Sarnoff CorporationMassively parallel detection
US587404630 Oct 199623 Feb 1999Raytheon CompanyBiological warfare agent sensor system employing ruthenium-terminated oligonucleotides complementary to target live agent DNA sequences
US58766755 Aug 19972 Mar 1999Caliper Technologies Corp.Microfluidic devices and systems
US58800716 Dec 19969 Mar 1999Caliper Technologies CorporationElectropipettor and compensation means for electrophoretic bias
US588246518 Jun 199716 Mar 1999Caliper Technologies Corp.Method of manufacturing microfluidic devices
US588321123 Apr 199616 Mar 1999Aclara Biosciences, Inc.Thermoreversible hydrogels comprising linear copolymers and their use in electrophoresis
US588543222 Jan 199623 Mar 1999Soane BiosciencesUn-crosslinked polymeric media for electrophoresis
US588547014 Apr 199723 Mar 1999Caliper Technologies CorporationControlled fluid transport in microfabricated polymeric substrates
US58957626 Mar 199720 Apr 1999Diasys CorporationApparatus and method for handling fluid samples of body materials
US590013018 Jun 19974 May 1999Alcara Biosciences, Inc.Method for sample injection in microchannel device
US591212414 Jun 199615 Jun 1999Sarnoff CorporationPadlock probe detection
US591213414 Jan 199715 Jun 1999Biometric Imaging, Inc.Disposable cartridge and method for an assay of a biological sample
US591652214 May 199829 Jun 1999Careside, Inc.Electrochemical analytical cartridge
US591677627 Aug 199729 Jun 1999Sarnoff CorporationAmplification method for a polynucleotide
US59196461 Aug 19976 Jul 1999Axiom Biotechnologies, Inc.Apparatus and method for real-time measurement of cellular response
US59197117 Aug 19976 Jul 1999Careside, Inc.Analytical cartridge
US592259127 Jun 199613 Jul 1999Affymetrix, Inc.Integrated nucleic acid diagnostic device
US592754712 Jun 199827 Jul 1999Packard Instrument CompanySystem for dispensing microvolume quantities of liquids
US592888011 Jun 199727 Jul 1999Trustees Of The University Of PennsylvaniaMesoscale sample preparation device and systems for determination and processing of analytes
US59292084 Oct 199627 Jul 1999Nanogen, Inc.Methods for electronic synthesis of polymers
US593279921 Jul 19973 Aug 1999Ysi IncorporatedMicrofluidic analyzer module
US593540118 Sep 199610 Aug 1999Aclara BiosciencesSurface modified electrophoretic chambers
US593929114 Jun 199617 Aug 1999Sarnoff CorporationMicrofluidic method for nucleic acid amplification
US594244328 Jun 199624 Aug 1999Caliper Technologies CorporationHigh throughput screening assay systems in microscale fluidic devices
US594822717 Dec 19977 Sep 1999Caliper Technologies Corp.Methods and systems for performing electrophoretic molecular separations
US595502814 Aug 199721 Sep 1999Caliper Technologies Corp.Analytical system and method
US595502912 Mar 199621 Sep 1999Trustees Of The University Of PennsylvaniaMesoscale polynucleotide amplification device and method
US595757930 Sep 199828 Sep 1999Caliper Technologies Corp.Microfluidic systems incorporating varied channel dimensions
US595820326 Jun 199728 Sep 1999Caliper Technologies CorportionElectropipettor and compensation means for electrophoretic bias
US595869416 Oct 199728 Sep 1999Caliper Technologies Corp.Apparatus and methods for sequencing nucleic acids in microfluidic systems
US59592214 Feb 199828 Sep 1999Bayer CorporationAutomatic closed tube sampler
US595929125 Jun 199828 Sep 1999Caliper Technologies CorporationMethod and apparatus for measuring low power signals
US59649954 Apr 199712 Oct 1999Caliper Technologies Corp.Methods and systems for enhanced fluid transport
US596499721 Mar 199712 Oct 1999Sarnoff CorporationBalanced asymmetric electronic pulse patterns for operating electrode-based pumps
US59650013 Jul 199712 Oct 1999Caliper Technologies CorporationVariable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
US596541025 Nov 199712 Oct 1999Caliper Technologies Corp.Electrical current for controlling fluid parameters in microchannels
US596588614 Mar 199712 Oct 1999Sarnoff CorporationInfrared imager using room temperature capacitance sensor
US597218720 Mar 199826 Oct 1999Caliper Technologies CorporationElectropipettor and compensation means for electrophoretic bias
US597313830 Oct 199826 Oct 1999Becton Dickinson And CompanyMethod for purification and manipulation of nucleic acids using paramagnetic particles
US597633625 Apr 19972 Nov 1999Caliper Technologies Corp.Microfluidic devices incorporating improved channel geometries
US59807047 Oct 19969 Nov 1999David Sarnoff Research Center Inc.Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
US598071929 Sep 19979 Nov 1999Sarnoff CorporationElectrohydrodynamic receptor
US598173512 Feb 19979 Nov 1999Cobra Therapeutics LimitedMethod of plasmid DNA production and purification
US598940229 Aug 199723 Nov 1999Caliper Technologies Corp.Controller/detector interfaces for microfluidic systems
US599282019 Nov 199730 Nov 1999Sarnoff CorporationFlow control in microfluidics devices by controlled bubble formation
US599361124 Sep 199730 Nov 1999Sarnoff CorporationCapacitive denaturation of nucleic acid
US599375011 Apr 199730 Nov 1999Eastman Kodak CompanyIntegrated ceramic micro-chemical plant
US599770830 Apr 19977 Dec 1999Hewlett-Packard CompanyMultilayer integrated assembly having specialized intermediary substrate
US60012291 Aug 199414 Dec 1999Lockheed Martin Energy Systems, Inc.Apparatus and method for performing microfluidic manipulations for chemical analysis
US600123115 Jul 199714 Dec 1999Caliper Technologies Corp.Methods and systems for monitoring and controlling fluid flow rates in microfluidic systems
US600130722 Apr 199714 Dec 1999Kyoto Daiichi Kagaku Co., Ltd.Device for analyzing a sample
US600451527 Oct 199821 Dec 1999Calipher Technologies Corp.Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems
US600769030 Jul 199728 Dec 1999Aclara Biosciences, Inc.Integrated microfluidic devices
US601060716 Sep 19984 Jan 2000Lockheed Martin Energy Research CorporationApparatus and method for performing microfluidic manipulations for chemical analysis and synthesis
US601060816 Sep 19984 Jan 2000Lockheed Martin Energy Research CorporationApparatus and method for performing microfluidic manipulations for chemical analysis and synthesis
US601062719 Jun 19964 Jan 2000Quantic Biomedical PartnersDevice for concentrating plasma
US601290225 Sep 199711 Jan 2000Caliper Technologies Corp.Micropump
US602492014 Apr 199915 Feb 2000Bio-Rad Laboratories, Inc.Microplate scanning read head
US603354615 Sep 19987 Mar 2000Lockheed Martin Energy Research CorporationApparatus and method for performing microfluidic manipulations for chemical analysis and synthesis
US604308011 Dec 199828 Mar 2000Affymetrix, Inc.Integrated nucleic acid diagnostic device
US60460566 Dec 19964 Apr 2000Caliper Technologies CorporationHigh throughput screening assay systems in microscale fluidic devices
US60487343 Jul 199711 Apr 2000The Regents Of The University Of MichiganThermal microvalves in a fluid flow method
US60540349 May 199725 Apr 2000Aclara Biosciences, Inc.Acrylic microchannels and their use in electrophoretic applications
US605427723 Mar 199825 Apr 2000Regents Of The University Of MinnesotaIntegrated microchip genetic testing system
US605686018 Sep 19972 May 2000Aclara Biosciences, Inc.Surface modified electrophoretic chambers
US605714915 Sep 19952 May 2000The University Of MichiganMicroscale devices and reactions in microscale devices
US606226116 Dec 199816 May 2000Lockheed Martin Energy Research CorporationMicrofluIdic circuit designs for performing electrokinetic manipulations that reduce the number of voltage sources and fluid reservoirs
US60633419 Jun 199816 May 2000Roche Diagnostics CorporationDisposable process device
US606358922 May 199816 May 2000Gamera Bioscience CorporationDevices and methods for using centripetal acceleration to drive fluid movement on a microfluidics system
US60714782 Feb 19996 Jun 2000Caliper Technologies Corp.Analytical system and method
US607472510 Dec 199713 Jun 2000Caliper Technologies Corp.Fabrication of microfluidic circuits by printing techniques
US60748275 Feb 199813 Jun 2000Aclara Biosciences, Inc.Microfluidic method for nucleic acid purification and processing
US608674029 Oct 199811 Jul 2000Caliper Technologies Corp.Multiplexed microfluidic devices and systems
US609650924 May 19991 Aug 2000Axiom Biotechnologies, Inc.Apparatus and method for compound profiling of living cells
US610054124 Feb 19988 Aug 2000Caliper Technologies CorporationMicrofluidic devices and systems incorporating integrated optical elements
US610289717 Nov 199715 Aug 2000Lang; VolkerMicrovalve
US610353730 Sep 199815 Aug 2000Aclara Biosciences, Inc.Capillary assays involving separation of free and bound species
US610668524 Dec 199722 Aug 2000Sarnoff CorporationElectrode combinations for pumping fluids
US61103434 Oct 199629 Aug 2000Lockheed Martin Energy Research CorporationMaterial transport method and apparatus
US612320526 Nov 199726 Sep 2000Bayer CorporationSample tube rack
US61237986 May 199826 Sep 2000Caliper Technologies Corp.Methods of fabricating polymeric structures incorporating microscale fluidic elements
US613009826 Sep 199710 Oct 2000The Regents Of The University Of MichiganMoving microdroplets
US613258028 Sep 199517 Oct 2000The Regents Of The University Of CaliforniaMiniature reaction chamber and devices incorporating same
US613268431 Oct 199717 Oct 2000Becton Dickinson And CompanySample tube holder
US613343619 Sep 199717 Oct 2000Sequenom, Inc.Beads bound to a solid support and to nucleic acids
US614325031 Jul 19967 Nov 2000Precision System Science Co., Ltd.Multi-vessel container for testing fluids
US614978714 Oct 199821 Nov 2000Caliper Technologies Corp.External material accession systems and methods
US615619911 Aug 19985 Dec 2000Zuk, Jr.; PeterCentrifugal filtration apparatus
US61582693 Dec 199812 Dec 2000Bayer CorporationMethod and apparatus for aspirating and dispensing sample fluids
US616791014 Jan 19992 Jan 2001Caliper Technologies Corp.Multi-layer microfluidic devices
US616894812 Jan 19982 Jan 2001Affymetrix, Inc.Miniaturized genetic analysis systems and methods
US61718508 Mar 19999 Jan 2001Caliper Technologies Corp.Integrated devices and systems for performing temperature controlled reactions and analyses
US617467527 Aug 199816 Jan 2001Caliper Technologies Corp.Electrical current for controlling fluid parameters in microchannels
US619061910 Jun 199820 Feb 2001Argonaut Technologies, Inc.Systems and methods for parallel synthesis of compounds
US619759519 Apr 19996 Mar 2001Affymetrix, Inc.Integrated nucleic acid diagnostic device
US62119894 Dec 19973 Apr 2001Bodenseewerk Perkin-Elmer GmbhLight-scanning device
US621315125 Apr 200010 Apr 2001Ut-Battelle, LlcMicrofluidic circuit designs for performing fluidic manipulations that reduce the number of pumping sources and fluid reservoirs
US62216008 Oct 199924 Apr 2001Board Of Regents, The University Of Texas SystemCombinatorial oligonucleotide PCR: a method for rapid, global expression analysis
US622863524 Jun 19978 May 2001Aastrom Bioscience, Inc.Portable cell growth cassette for use in maintaining and growing biological cells
US62351752 Oct 199822 May 2001Caliper Technologies Corp.Microfluidic devices incorporating improved channel geometries
US623531326 Mar 199722 May 2001Brown University Research FoundationBioadhesive microspheres and their use as drug delivery and imaging systems
US62354713 Apr 199822 May 2001Caliper Technologies Corp.Closed-loop biochemical analyzers
US623658114 Jan 200022 May 2001Mosaid Technologies IncorporatedHigh voltage boosted word line supply charge pump and regulator for DRAM
US625134324 Feb 199826 Jun 2001Caliper Technologies Corp.Microfluidic devices and systems incorporating cover layers
US625482613 Nov 19983 Jul 2001Gen-Probe IncorporatedAssay work station
US625963519 Jan 200010 Jul 2001Stmicroelectronics S.R.L.Capacitive boosting circuit for the regulation of the word line reading voltage in non-volatile memories
US626143128 Dec 199817 Jul 2001Affymetrix, Inc.Process for microfabrication of an integrated PCR-CE device and products produced by the same
US626785824 Jun 199731 Jul 2001Caliper Technologies Corp.High throughput screening assay systems in microscale fluidic devices
US627102118 Mar 19997 Aug 2001The Regents Of The University Of MichiganMicroscale devices and reactions in microscale devices
US62740898 Jun 199814 Aug 2001Caliper Technologies Corp.Microfluidic devices, systems and methods for performing integrated reactions and separations
US62809675 Aug 199928 Aug 2001Axiom Biotechnologies, Inc.Cell flow apparatus and method for real-time of cellular responses
US62810081 Feb 199928 Aug 2001Toyo Boseki Kabushiki KaishaNucleic acid extraction apparatus
US628411315 Sep 19984 Sep 2001Aclara Biosciences, Inc.Apparatus and method for transferring liquids
US62872542 Nov 199911 Sep 2001W. Jean DoddsAnimal health diagnosis
US628777421 May 199911 Sep 2001Caliper Technologies Corp.Assay methods and system
US629124811 Sep 200018 Sep 2001Norgen Biotek CorporationNucleic acid purification and process
US629406312 Feb 199925 Sep 2001Board Of Regents, The University Of Texas SystemMethod and apparatus for programmable fluidic processing
US630213415 Mar 200016 Oct 2001Tecan BostonDevice and method for using centripetal acceleration to device fluid movement on a microfluidics system
US630230420 Sep 199616 Oct 2001Rieke Packaging Systems LimitedDispensing systems
US63033436 Apr 199916 Oct 2001Caliper Technologies Corp.Inefficient fast PCR
US630627313 Apr 199923 Oct 2001Aclara Biosciences, Inc.Methods and compositions for conducting processes in microfluidic devices
US63065908 Jun 199823 Oct 2001Caliper Technologies Corp.Microfluidic matrix localization apparatus and methods
US631946918 Dec 199620 Nov 2001Silicon Valley BankDevices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
US632268314 Apr 199927 Nov 2001Caliper Technologies Corp.Alignment of multicomponent microfabricated structures
US63260838 Mar 19994 Dec 2001Calipher Technologies Corp.Surface coating for microfluidic devices that incorporate a biopolymer resistant moiety
US632621110 Mar 20004 Dec 2001Affymetrix, Inc.Method of manipulating a gas bubble in a microfluidic device
US633743510 Jul 20008 Jan 2002Bio-Rad Laboratories, Inc.Temperature control for multi-vessel reaction apparatus
US635347519 Aug 19995 Mar 2002Caliper Technologies Corp.Light source power modulation for use with chemical and biochemical analysis
US635838727 Mar 200019 Mar 2002Caliper Technologies CorporationUltra high throughput microfluidic analytical systems and methods
US636692427 Jul 19982 Apr 2002Caliper Technologies Corp.Distributed database for analytical instruments
US636887113 Aug 19979 Apr 2002CepheidNon-planar microstructures for manipulation of fluid samples
US63702064 Dec 20009 Apr 2002Infineon Technologies AgAdaptive cap receiver and method for controlling a cap receiver
US637518520 Oct 200023 Apr 2002Gamemax CorporationPaper currency receiving control assembly for currency-coin exchange machine
US637590120 Apr 199923 Apr 2002Agilent Technologies, Inc.Chemico-mechanical microvalve and devices comprising the same
US637988428 Dec 200030 Apr 2002Caliper Technologies Corp.Methods and systems for monitoring intracellular binding reactions
US637992919 Nov 199730 Apr 2002The Regents Of The University Of MichiganChip-based isothermal amplification devices and methods
US637997419 Aug 199930 Apr 2002Caliper Technologies Corp.Microfluidic systems
US639154130 May 200021 May 2002Kurt E. PetersenApparatus for analyzing a fluid sample
US63916239 Feb 200021 May 2002Affymetrix, Inc.Fluidics station injection needles with distal end and side ports and method of using
US639516112 Jun 199928 May 2002Robert Bosch GmbhGas sensor and corresponding production method
US639895630 May 20004 Jun 2002Bio/Data CorporationMethod and apparatus for directly sampling a fluid for microfiltration
US639902521 Mar 20004 Jun 2002Caliper Technologies Corp.Analytical system and method
US63993897 Jul 20004 Jun 2002Caliper Technologies Corp.High throughput screening assay systems in microscale fluidic devices
US639995212 May 20004 Jun 2002Aclara Biosciences, Inc.Multiplexed fluorescent detection in microfluidic devices
US640333827 Jun 200011 Jun 2002Mountain ViewMicrofluidic systems and methods of genotyping
US640887828 Feb 200125 Jun 2002California Institute Of TechnologyMicrofabricated elastomeric valve and pump systems
US64134013 Jul 19972 Jul 2002Caliper Technologies Corp.Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
US64166425 Feb 19999 Jul 2002Caliper Technologies Corp.Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection
US642014313 Feb 199816 Jul 2002Caliper Technologies Corp.Methods and systems for performing superheated reactions in microscale fluidic systems
US64259724 Feb 199930 Jul 2002Calipher Technologies Corp.Methods of manufacturing microfabricated substrates
US642898712 Dec 20006 Aug 2002Bruker Daltonik GmbhDevices for fast DNA replication by polymerase chain reactions (PCR)
US643051229 Dec 19986 Aug 2002Caliper Technologies Corp.Software for the display of chromatographic separation data
US64323669 Feb 200113 Aug 2002Bristol-Myers Squibb CompanyApparatus for synthesis of multiple organic compounds with pinch valve block
US644072524 Dec 199827 Aug 2002CepheidIntegrated fluid manipulation cartridge
US644446120 Sep 20003 Sep 2002Caliper Technologies Corp.Microfluidic devices and methods for separation
US644766112 Oct 199910 Sep 2002Caliper Technologies Corp.External material accession systems and methods
US644772717 Nov 199710 Sep 2002Caliper Technologies Corp.Microfluidic systems
US644806429 Jan 200110 Sep 2002Ut-Battelle, LlcIntegrated circuit biochip microsystem
US64539288 Jan 200124 Sep 2002Nanolab Ltd.Apparatus, and method for propelling fluids
US646525718 Nov 199715 Oct 2002Caliper Technologies Corp.Microfluidic systems
US64687615 Jan 200122 Oct 2002Caliper Technologies, Corp.Microfluidic in-line labeling method for continuous-flow protease inhibition analysis
US647214111 May 200029 Oct 2002Caliper Technologies Corp.Kinase assays using polycations
US64753642 Feb 20005 Nov 2002Caliper Technologies Corp.Methods, devices and systems for characterizing proteins
US64888971 May 20013 Dec 2002Caliper Technologies Corp.Microfluidic devices and systems incorporating cover layers
US649510419 Aug 199917 Dec 2002Caliper Technologies Corp.Indicator components for microfluidic systems
US649849713 Aug 199924 Dec 2002Caliper Technologies Corp.Microfluidic controller and detector system with self-calibration
US650032326 Mar 199931 Dec 2002Caliper Technologies Corp.Methods and software for designing microfluidic devices
US650039013 Dec 199931 Dec 2002David A. BoultonMethod for sealing and venting a microplate assembly
US650660911 May 200014 Jan 2003Caliper Technologies Corp.Focusing of microparticles in microfluidic systems
US650919320 May 199621 Jan 2003Precision System Science Co., Ltd.Method and apparatus for controlling magnetic particles by pipetting machine
US65118532 Aug 200028 Jan 2003Caliper Technologies Corp.Optimized high-throughput analytical system
US651575317 May 20014 Feb 2003Aclara Biosciences, Inc.Optical alignment in capillary detection using capillary wall scatter
US65177839 Mar 200111 Feb 2003Gen-Probe IncorporatedReaction receptacle apparatus
US652019730 May 200118 Feb 2003The Regents Of The University Of CaliforniaContinuous laminar fluid mixing in micro-electromechanical systems
US652118822 Nov 200018 Feb 2003Industrial Technology Research InstituteMicrofluidic actuator
US652445629 Sep 199925 Feb 2003Ut-Battelle, LlcMicrofluidic devices for the controlled manipulation of small volumes
US65247908 Jun 199825 Feb 2003Caliper Technologies Corp.Apparatus and methods for correcting for variable velocity in microfluidic systems
US653429511 Sep 200118 Mar 2003California Institute Of TechnologyCell lysis device
US65377716 Oct 200025 Mar 2003Caliper Technologies Corp.Use of nernstein voltage sensitive dyes in measuring transmembrane voltage
US65408964 Aug 19991 Apr 2003Caliper Technologies Corp.Open-Field serial to parallel converter
US65447349 Dec 19998 Apr 2003Cynthia G. BriscoeMultilayered microfluidic DNA analysis system and method
US654794225 Jun 199715 Apr 2003Caliper Technologies Corp.Electropipettor and compensation means for electrophoretic bias
US655538923 Dec 199929 Apr 2003Aclara Biosciences, Inc.Sample evaporative control
US655692326 Jan 200029 Apr 2003Caliper Technologies Corp.Software for high throughput microfluidic systems
US65589167 Feb 20016 May 2003Axiom Biotechnologies, Inc.Cell flow apparatus and method for real-time measurements of patient cellular responses
US65589458 Mar 20006 May 2003Aclara Biosciences, Inc.Method and device for rapid color detection
US65696071 May 200127 May 2003Caliper Technologies Corp.Multi depth substrate fabrication processes
US657283021 Jun 19993 Jun 2003Motorola, Inc.Integrated multilayered microfludic devices and methods for making the same
US657518818 Sep 200110 Jun 2003Handylab, Inc.Methods and systems for fluid control in microfluidic devices
US657645923 Mar 200110 Jun 2003The Regents Of The University Of CaliforniaSample preparation and detection device for infectious agents
US657945329 Sep 199817 Jun 2003Roche Diagnostics CorporationApparatus for separating magnetic particles
US658972931 Jan 20018 Jul 2003Caliper Technologies Corp.Methods, devices, and systems for monitoring time dependent reactions
US659282110 May 200115 Jul 2003Caliper Technologies Corp.Focusing of microparticles in microfluidic systems
US659745014 Jan 200022 Jul 2003Becton, Dickinson And CompanyAutomated Optical Reader for Nucleic Acid Assays
US66024742 Oct 20005 Aug 2003Precision System Science Co., Ltd.Multi-vessel container for testing fluids
US661321117 Aug 20002 Sep 2003Aclara Biosciences, Inc.Capillary electrokinesis based cellular assays
US66135128 Jun 19982 Sep 2003Caliper Technologies Corp.Apparatus and method for correcting for variable velocity in microfluidic systems
US661358030 Jun 20002 Sep 2003Caliper Technologies Corp.Microfluidic systems and methods for determining modulator kinetics
US661358117 Aug 20002 Sep 2003Caliper Technologies Corp.Microfluidic analytic detection assays, devices, and integrated systems
US661403015 May 20022 Sep 2003Aclara Biosciences, Inc.Multiplexed fluorescent detection in microfluidic devices
US662062528 Dec 200016 Sep 2003Caliper Technologies Corp.Ultra high throughput sampling and analysis systems and methods
US662386010 Oct 200123 Sep 2003Aclara Biosciences, Inc.Multilevel flow structures
US662740610 May 200030 Sep 2003Aclara Biosciences, Inc.Sample evaporative control
US663265522 Feb 200014 Oct 2003Caliper Technologies Corp.Manipulation of microparticles in microfluidic systems
US664935825 May 200018 Nov 2003Caliper Technologies Corp.Microscale assays and microfluidic devices for transporter, gradient induced, and binding activities
US66641047 Nov 200116 Dec 2003CepheidDevice incorporating a microfluidic chip for separating analyte from a sample
US666983110 May 200130 Dec 2003Caliper Technologies Corp.Microfluidic devices and methods to regulate hydrodynamic and electrical resistance utilizing bulk viscosity enhancers
US667015313 Sep 200130 Dec 2003Caliper Technologies Corp.Microfluidic devices and methods for performing temperature mediated reactions
US66816169 Nov 200127 Jan 2004Caliper Technologies Corp.Microfluidic viscometer
US668178824 Jan 200227 Jan 2004Caliper Technologies Corp.Non-mechanical valves for fluidic systems
US668581320 Aug 20013 Feb 2004Aclara Biosciences, Inc.Tandem isotachophoresis/zone electrophoresis method and system
US669270014 Feb 200117 Feb 2004Handylab, Inc.Heat-reduction methods and systems related to microfluidic devices
US669500930 Oct 200124 Feb 2004Caliper Technologies Corp.Microfluidic methods, devices and systems for in situ material concentration
US670651922 Jun 200016 Mar 2004Tecan Trading AgDevices and methods for the performance of miniaturized in vitro amplification assays
US672014820 Feb 200213 Apr 2004Caliper Life Sciences, Inc.Methods and systems for identifying nucleotides by primer extension
US673020617 Mar 20014 May 2004Aclara Biosciences, Inc.Microfluidic device and system with improved sample handling
US673364512 Apr 200111 May 2004Caliper Technologies Corp.Total analyte quantitation
US673440128 Jun 200111 May 20043M Innovative Properties CompanyEnhanced sample processing devices, systems and methods
US675066112 Nov 200215 Jun 2004Caliper Life Sciences, Inc.Method and apparatus for controllably effecting samples using two signals
US67529661 Sep 200022 Jun 2004Caliper Life Sciences, Inc.Microfabrication methods and devices
US67560196 Apr 200029 Jun 2004Caliper Technologies Corp.Microfluidic devices and systems incorporating cover layers
US676681725 Feb 200227 Jul 2004Tubarc Technologies, LlcFluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action
US677356714 Sep 200010 Aug 2004Caliper Life Sciences, Inc.High-throughput analytical microfluidic systems and methods of making same
US677718411 May 200117 Aug 2004Caliper Life Sciences, Inc.Detection of nucleic acid hybridization by fluorescence polarization
US678396224 Mar 200031 Aug 2004Upfront ChromatographyParticulate material for purification of bio-macromolecules
US678701520 Jul 20017 Sep 2004Aclara Biosciences, Inc.Methods for conducting electrophoretic analysis
US67870161 May 20017 Sep 2004Aclara Biosciences, Inc.Dynamic coating with linear polymer mixture for electrophoresis
US679032812 Jan 200114 Sep 2004Ut-Battelle, LlcMicrofluidic device and method for focusing, segmenting, and dispensing of a fluid stream
US679033014 Jun 200114 Sep 2004Board Of Regents, The University Of Texas SystemSystems and methods for cell subpopulation analysis
US681166815 Jun 20002 Nov 2004Caliper Life Sciences, Inc.Apparatus for the operation of a microfluidic device
US681811310 Feb 200116 Nov 2004Aclara Biosciences, Inc.Microfluidic device with sample injector and method of using
US68190274 Mar 200216 Nov 2004CepheidMethod and apparatus for controlling ultrasonic transducer
US682466325 Aug 200030 Nov 2004Aclara Biosciences, Inc.Efficient compound distribution in microfluidic devices
US682783126 Aug 19987 Dec 2004Callper Life Sciences, Inc.Controller/detector interfaces for microfluidic systems
US68279069 May 20007 Dec 2004Aclara Biosciences, Inc.Continuous form microstructure assay array
US683815629 Mar 20004 Jan 2005Aclara Biosciences, Inc.Method for linking two plastic work pieces without using foreign matter
US683868023 Jul 20024 Jan 2005Aclara Biosciences, Inc.Multiplexed fluorescent detection in microfluidic devices
US685228712 Sep 20018 Feb 2005Handylab, Inc.Microfluidic devices having a reduced number of input and output connections
US685818523 Aug 200022 Feb 2005Caliper Life Sciences, Inc.Dilutions in high throughput systems with a single vacuum source
US685969821 Jun 200122 Feb 2005Snap-On IncorporatedDetachable cartridge unit and auxiliary unit for function expansion of a data processing system
US686103530 Jul 20021 Mar 2005Aurora Discovery, Inc.Multi-well platforms, caddies, lids and combinations thereof
US68785407 Nov 200112 Apr 2005CepheidDevice for lysing cells, spores, or microorganisms
US687875522 Jan 200112 Apr 2005Microgen Systems, Inc.Automated microfabrication-based biodetector
US688462828 Apr 200026 Apr 2005Eidgenossische Technische Hochschule ZurichMultifunctional polymeric surface coatings in analytic and sensor devices
US68876937 Nov 20013 May 2005CepheidDevice and method for lysing cells, spores, or microorganisms
US68938797 Nov 200117 May 2005CepheidMethod for separating analyte from a sample
US690088918 Dec 200331 May 2005Aclara Biosciences, Inc.Submersible light-directing member for material excitation in microfluidic devices
US690558310 Dec 200314 Jun 2005Aclara Biosciences, Inc.Closed-loop control of electrokinetic processes in microfluidic devices based on optical readings
US690561221 Mar 200314 Jun 2005Hanuman LlcPlasma concentrate apparatus and method
US690679713 Sep 200014 Jun 2005Aclara Biosciences, Inc.Side light activated microfluid channels
US690859418 Oct 200021 Jun 2005Aclara Biosciences, Inc.Efficient microfluidic sealing
US69111836 Mar 200028 Jun 2005The Regents Of The University Of MichiganMoving microdroplets
US691413714 Dec 20005 Jul 2005Dna Research Innovations LimitedIsolation of nucleic acids
US691567923 Feb 200112 Jul 2005Caliper Life Sciences, Inc.Multi-reservoir pressure control system
US691840413 Apr 200419 Jul 2005Tubarc Technologies, LlcIrrigation and drainage based on hydrodynamic unsaturated fluid flow
US693945124 Aug 20016 Sep 2005Aclara Biosciences, Inc.Microfluidic chip having integrated electrodes
US694277121 Apr 199913 Sep 2005Clinical Micro Sensors, Inc.Microfluidic systems in the electrochemical detection of target analytes
US695839218 Jul 200125 Oct 2005Whatman, Inc.Methods for the isolation of nucleic acids and for quantitative DNA extraction and detection for leukocyte evaluation in blood products
US696474721 Jan 200315 Nov 2005Bioarray Solutions, Ltd.Production of dyed polymer microparticles
US69771634 Jun 200220 Dec 2005Caliper Life Sciences, Inc.Methods and systems for performing multiple reactions by interfacial mixing
US698451610 Jan 200310 Jan 2006Motorola, Inc.Multilayered microfluidic DNA analysis system and method
US700185328 Aug 200321 Feb 2006Caliper Life Sciences, Inc.Flow control of photo-polymerizable resin
US700418423 Jul 200128 Feb 2006The Reagents Of The University Of MichiganCompositions and methods for liquid metering in microchannels
US701039128 Mar 20017 Mar 2006Handylab, Inc.Methods and systems for control of microfluidic devices
US702300716 Jan 20034 Apr 2006Caliper Life Sciences, Inc.Methods and systems for alignment of detection optics
US702428110 Dec 20014 Apr 2006Callper Life Sciences, Inc.Software for the controlled sampling of arrayed materials
US70366674 May 20042 May 2006Caliper Life Sciences, Inc.Container providing a controlled hydrated environment
US703741611 Jan 20012 May 2006Caliper Life Sciences, Inc.Method for monitoring flow rate using fluorescent markers
US703847212 May 20032 May 2006Caliper Life Sciences, Inc.Methods and systems for measuring internal dimensions of microscale structures
US703952730 Sep 20042 May 2006Caliper Life Sciences, Inc.Method for measuring diffusivities of compounds using microchips
US704014426 Jul 20029 May 2006Caliper Life Sciences, Inc.Microfluidic viscometer
US70556952 Jun 20036 Jun 2006Caliper Life Sciencee, Inc.Container providing a controlled hydrated environment
US706017124 Jul 200213 Jun 2006Caliper Life Sciences, Inc.Methods and systems for reducing background signal in assays
US706658613 Apr 200427 Jun 2006Tubarc Technologies, LlcInk refill and recharging system
US706995212 Nov 20024 Jul 2006Caliper Life Sciences, Inc.Microfluidic devices and methods of their manufacture
US709977830 Dec 200329 Aug 2006Caliper Life Sciences, Inc.Method for determining diffusivity and molecular weight in a microfluidic device
US710146722 Dec 20035 Sep 2006Caliper Life Sciences, Inc.Mixed mode microfluidic systems
US71053045 Nov 200112 Sep 2006Caliper Life Sciences, Inc.Pressure-based mobility shift assays
US711891027 Nov 200210 Oct 2006Fluidigm CorporationMicrofluidic device and methods of using same
US71380326 Feb 200321 Nov 2006Caliper Life Sciences, Inc.Methods of fabricating polymeric structures incorporating microscale fluidic elements
US71480438 May 200312 Dec 2006Bio-Rad Laboratories, Inc.Systems and methods for fluorescence detection with a movable detection module
US71508148 Aug 200219 Dec 2006Callper Life Sciences, Inc.Prevention of surface adsorption in microchannels by application of electric current during pressure-induced flow
US71509995 Mar 200219 Dec 2006Califer Life Sciences, Inc.Process for filling microfluidic channels
US71604234 Mar 20039 Jan 2007Caliper Life Sciences, Inc.Mixed mode microfluidic systems
US716135612 May 20039 Jan 2007Caliper Life Sciences, Inc.Voltage/current testing equipment for microfluidic devices
US716927731 Jul 200130 Jan 2007Caliper Life Sciences, Inc.High throughput separations based analysis systems
US716961826 Jun 200130 Jan 2007Skold TechnologyMagnetic particles and methods of producing coated magnetic particles
US719255714 Dec 200120 Mar 2007Handylab, Inc.Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids
US71959867 Mar 200327 Mar 2007Caliper Life Sciences, Inc.Microfluidic device with controlled substrate conductivity
US720812525 Jun 200324 Apr 2007Caliper Life Sciences, IncMethods and apparatus for minimizing evaporation of sample materials from multiwell plates
US723540628 Jul 200026 Jun 2007Applera CorporationNucleic acid analysis device
US724727412 Nov 200224 Jul 2007Caliper Technologies Corp.Prevention of precipitate blockage in microfluidic channels
US725292825 Feb 20037 Aug 2007Caliper Life Sciences, Inc.Methods for prevention of surface adsorption of biological materials to capillary walls in microchannels
US727078614 Dec 200118 Sep 2007Handylab, Inc.Methods and systems for processing microfluidic samples of particle containing fluids
US727633017 Apr 20032 Oct 2007Caliper Technologies Corp.Devices, systems and methods for time domain multiplexing of reagents
US730372719 Feb 20034 Dec 2007Caliper Life Sciences, IncMicrofluidic sample delivery devices, systems, and methods
US732314015 Feb 200229 Jan 2008Handylab, Inc.Moving microdroplets in a microfluidic device
US733213017 Feb 200419 Feb 2008Handylab, Inc.Heat-reduction methods and systems related to microfluidic devices
US733876024 Oct 20024 Mar 2008Ntu Ventures Private LimitedSample preparation integrated chip
US735137718 Jun 20011 Apr 2008Caliper Life Sciences, Inc.Methods and devices for enhancing bonded substrate yields and regulating temperature
US737494910 May 200420 May 2008Bayer Healthcare LlcDiagnostic test strip for collecting and detecting an analyte in a fluid sample
US739046018 Nov 200324 Jun 2008Hitachi Koki Co., Ltd.Control device for automatic liquid handling system
US741978427 Mar 20032 Sep 2008Dubrow Robert SMethods, systems and apparatus for separation and isolation of one or more sample components of a sample biological material
US742266916 Jan 20049 Sep 2008Ut-Battelle, LlcMicrofluidic device and method for focusing, segmenting, and dispensing of a fluid stream
US744068430 Dec 200521 Oct 2008Spaid Michael AMethod and apparatus for improved temperature control in microfluidic devices
US747631317 May 200613 Jan 2009Iqbal Waheed SiddiqiApparatus for mixing magnetic particles
US749457730 Sep 200324 Feb 2009Monogram Biosciences, Inc.Tandem isotachophoresis/zone electrophoresis method and system
US749477030 Apr 200324 Feb 2009Trustees Of The University Of PennsylvaniaMesoscale polynucleotide amplification analysis
US75140464 Jun 20047 Apr 2009Caliper Life Sciences, Inc.Methods and systems for processing microscale devices for reuse
US751872612 Apr 200614 Apr 2009Caliper Lifesciences, Inc.Compact optical detection system for a microfluidic device
US752118610 Sep 200321 Apr 2009Caliper Lifesciences Inc.PCR compatible nucleic acid sieving matrix
US75277695 May 20065 May 2009Caliper Life Sciences, Inc.Microtitre plate with a relieved perimeter
US755367125 May 200430 Jun 2009Vertex Pharmaceuticals, Inc.Modular test tube rack
US759519710 May 200429 Sep 2009Caliper Life Sciences, Inc.Automated sample analysis
US760493817 Feb 200620 Oct 2009Canon U.S. Life Sciences, Inc.Devices and methods for monitoring genomic DNA of organisms
US763558819 May 200322 Dec 2009Applied Biosystems, LlcApparatus and method for differentiating multiple fluorescence signals by excitation wavelength
US76455814 Oct 200712 Jan 2010Caliper Life Sciences, Inc.Determining nucleic acid fragmentation status by coincident detection of two labeled probes
US767055919 Aug 20022 Mar 2010Caliper Life Sciences, Inc.Microfluidic systems with enhanced detection systems
US770473526 Apr 200727 Apr 2010Fluidigm CorporationIntegrated chip carriers with thermocycler interfaces and methods of using the same
US772312331 May 200225 May 2010Caliper Life Sciences, Inc.Western blot by incorporating an affinity purification zone
US77273717 Oct 20051 Jun 2010Caliper Life Sciences, Inc.Electrode apparatus for use with a microfluidic device
US772747728 Nov 20051 Jun 2010Bio-Rad Laboratories, Inc.Apparatus for priming microfluidics devices with feedback control
US77448176 Feb 200629 Jun 2010Sakura Finetek U.S.A., Inc.Manifold assembly
US78677766 May 200411 Jan 2011Caliper Life Sciences, Inc.Priming module for microfluidic chips
US789281911 Aug 200322 Feb 2011Trustees Of The University Of PennsylvaniaMesoscale polynucleotide amplification devices
US200100238485 Apr 200127 Sep 2001Gjerde Douglas T.Non-polar media for polynucleotide separations
US2001003845029 Mar 20018 Nov 2001Mccaffrey John T.Methods and apparatus to improve the sensitivity and reproducibility of bioluminescent analytical methods
US2001004670219 Jun 200129 Nov 2001Schembri Carol T.Devices for performing array hybridization assays and methods of using the same
US2001005576520 Feb 200127 Dec 2001O'keefe MatthewApparatus and methods for parallel processing of micro-volume liquid reactions
US2002000184818 Apr 20013 Jan 20023M Innovative Properties CompanyMulti-format sample processing devices, methods and systems
US2002000901520 Mar 200124 Jan 2002Laugharn James A.Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
US2002001566712 Oct 20017 Feb 2002Caliper Technologies Corp.Analytical system and method
US2002002198323 Jul 200121 Feb 2002Comte Roger LeDevice for processing samples of blood products
US200200374995 Jun 200128 Mar 2002California Institute Of TechnologyIntegrated active flux microfluidic devices and methods
US200200397837 Nov 20014 Apr 2002CepheidDevice and method for lysing cells, spores, or microorganisms
US200200533997 Dec 20019 May 2002Aclara Biosciences, IncMethods for fabricating enclosed microchannel structures
US2002005483514 Dec 20019 May 2002Robotti Karla M.Chemico-mechanical microvalve and devices comprising the same
US200200551677 Nov 20019 May 2002CepheidDevice incorporating a microfluidic chip for separating analyte from a sample
US2002006015616 Jul 200123 May 2002Affymetrix, Inc.Integrated microvolume device
US200200683579 Aug 20016 Jun 2002Mathies Richard A.Miniaturized integrated nucleic acid processing and analysis device and method
US2002014190314 Dec 20013 Oct 2002Gene ParunakMethods and systems for processing microfluidic samples of particle containing fluids
US2002014247115 Feb 20023 Oct 2002Kalyan HandiqueMethods and systems for moving fluid in a microfluidic device
US2002014329727 Mar 20023 Oct 2002Becton, Dickinson And CompanyAdaptor for use with point-of-care testing cartridge
US2002014343728 Mar 20013 Oct 2002Kalyan HandiqueMethods and systems for control of microfluidic devices
US2002016951824 Apr 200114 Nov 2002Luoma Robert P.Sample handling system
US200201875573 Jun 200212 Dec 2002Hobbs Steven E.Systems and methods for introducing samples into microfluidic devices
US2003001952218 Sep 200130 Jan 2003Gene ParunakMethods and systems for fluid control in microfluidic devices
US2003004983311 Sep 200213 Mar 2003Shuqi ChenSample vessels
US2003007067723 Jul 200117 Apr 2003The Regents Of The University Of MichiganCompositions and methods for liquid metering in microchannels
US2003007310631 May 200217 Apr 2003Johansen Jack T.Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices
US2003008368619 Apr 20021 May 2003Freeman Dominique M.Tissue penetration device
US2003008730022 Nov 20028 May 2003Caliper Technologies Corp.Microfluidic sequencing methods
US2003012732727 Dec 200210 Jul 2003Kurnik Ronald T.Microfluidic device and method for improved sample handling
US2003013667918 Oct 200224 Jul 2003The Board Of Trustees Of The University Of IllinoisHybrid microfluidic and nanofluidic system
US2003018629527 Aug 20012 Oct 2003Bruno ColinReaction card and use of same
US2003019908130 Apr 200323 Oct 2003Peter WildingMesoscale polynucleotide amplification analysis
US2003021151722 Jun 200113 Nov 2003Carulli John P.Gp354 nucleic acids and polypeptides
US2004001423817 Jan 200322 Jan 2004Krug Robert E.Precision liquid dispensing system
US2004002925811 Apr 200312 Feb 2004Paul HeaneyMethods and devices for performing chemical reactions on a solid support
US2004005329011 Apr 200318 Mar 2004Terbrueggen Robert HenryDevices and methods for biochip multiplexing
US2004006321714 May 20031 Apr 2004Webster James RussellMiniaturized fluid delivery and analysis system
US200400722781 Apr 200315 Apr 2004Fluidigm CorporationMicrofluidic particle-analysis systems
US2004007237514 Jul 200315 Apr 2004Gjerde Douglas T.Low dead volume extraction column device
US200401418877 Nov 200322 Jul 2004Irm, LlcApparatus and methods to process substrate surface features
US2004015162931 Jan 20035 Aug 2004Grant PeaseMicrofluidic device with thin-film electronic devices
US2004015722010 Feb 200312 Aug 2004Purnima KurnoolMethods and apparatus for sample tracking
US200401617885 Feb 200419 Aug 2004Shuqi ChenSample processing
US2004018931123 Dec 200330 Sep 2004Glezer Eli N.Assay cartridges and methods of using the same
US2004020933116 Jul 200221 Oct 2004Kirk RirieThermal cycling system and method of use
US2004020935429 Dec 200321 Oct 2004The Regents Of The University Of CaliforniaFluid control structures in microfluidic devices
US2004021907017 Feb 20044 Nov 2004Handylab, Inc., A Delaware CorporationHeat-reduction methods and systems related to microfluidic devices
US2004024009727 Apr 20042 Dec 2004Hewlett-Packard Development Company, L.P.Method and apparatus for use in data transfer
US2005000917430 Jun 200413 Jan 2005Caliper Life Sciences, Inc.Detection of nucleic acid hybridization by fluorescence polarization
US2005004854018 Jun 20043 Mar 2005Hisao InamiChip for processing of gene and apparatus for processing of gene
US200500844242 Aug 200421 Apr 2005Karthik GanesanSystems and methods for thermal actuation of microfluidic devices
US2005010606617 Jun 200419 May 2005Micronics, Inc.Microfluidic devices for fluid manipulation and analysis
US200501213247 Sep 20049 Jun 2005Caliper Life Sciences, Inc.Analyte injection system
US2005013337012 Jun 200423 Jun 2005Caliper Life Sciences, Inc.Analyte injection system
US2005013565513 Jan 200523 Jun 2005Caliper Life Sciences, Inc.Ultra high throughput microfluidic analytical systems and methods
US2005015280812 Sep 200214 Jul 2005Karthik GanesanMicrofluidic devices having a reduced number of input and output connections
US200501703628 Apr 20044 Aug 2005Caliper Life Sciences, Inc.Reduction of migration shift assay interference
US2005020247011 Jan 200515 Sep 2005Caliper Life Sciences, Inc.Binding assays using molecular melt curves
US200502025046 May 200515 Sep 2005Affymetrix, Inc.Miniaturized genetic analysis systems and methods
US2005020867617 Mar 200522 Sep 2005Espir KahattDevice for aspirating, manipulating, mixing and dispensing nano-volumes of liquids
US2005022067522 Mar 20056 Oct 2005Reed Mark THigh density plate filler
US2005022726918 Feb 200513 Oct 2005Research Think Tank, Inc.Devices and methods for collection, storage and transportation of biological specimens
US2005023337023 May 200520 Oct 2005Gen-Probe IncorporatedMethod for agitating the fluid contents of a container
US2005023854523 Jun 200527 Oct 2005Caliper Life Sciences, Inc.Control of operation conditions within fluidic systems
US2005027207929 Apr 20058 Dec 2005The Regents Of The University Of MichiganThermal microvalves
US2006004105822 Nov 200423 Feb 2006Anp Technologies, Inc.Asymmetrically branched polymer conjugates and microarray assays
US200600570392 Aug 200516 Mar 2006The Regents Of The University Of CaliforniaChemical microreactor and method thereof
US2006005762914 Sep 200516 Mar 2006Min-Soo KimDevice for injecting PCR solution into PCR channels of PCR chip, and PCR chip unit including the device
US200600626967 Nov 200523 Mar 2006Caliper Life Sciences, Inc.Optimized high throughput analytical systems
US2006009410815 Sep 20054 May 2006Karl YoderThermal cycler for microfluidic array assays
US200601131906 Jan 20061 Jun 2006Kurnik Ronald TMicrofluidic device and method for improved sample handling
US2006013396530 Jan 200422 Jun 2006Universal Bio Research Co., Ltd.Monitoring function-equipped dispensing system and method of monitoring dispensing device
US2006013479014 Dec 200522 Jun 2006Yasunobu TanakaSolid surface with immobilized degradable cationic polymer for transfecting eukaryotic cells
US2006014806316 Sep 20056 Jul 2006Fauzzi John AMethod and apparatus for automated pre-treatment and processing of biological samples
US2006016555819 Dec 200527 Jul 2006Thomas WittyCartridge for diagnostic assays
US2006016555920 May 200527 Jul 2006Caliper Life Sciences, Inc.Automated system for handling microfluidic devices
US2006016623316 Nov 200527 Jul 2006Handylab, Inc.Method and apparatus for processing polynucleotide-containing samples
US2006017737621 Jul 200410 Aug 2006Dendritic Nanotechnologies, Inc.Stabilized and chemically functionalized nanoparticles
US2006018321623 Jan 200617 Aug 2006Kalyan HandiqueContainers for liquid storage and delivery with application to microfluidic devices
US2006020794417 May 200621 Sep 2006Siddiqi Iqbal WApparatus for mixing magnetic particles
US200602464934 Apr 20062 Nov 2006Caliper Life Sciences, Inc.Method and apparatus for use in temperature controlled processing of microfluidic samples
US200602465333 Apr 20062 Nov 2006Caliper Life Sciences, Inc.Method and apparatus for performing peptide digestion on a microfluidic device
US2007000402810 Mar 20064 Jan 2007Gen-Probe IncorporatedSignal measuring system for conducting real-time amplification assays
US2007000938630 Jun 200611 Jan 2007Honeywell International Inc.Molded cartridge with 3-d hydrodynamic focusing
US2007002069919 Jul 200525 Jan 2007Idexx Laboratories, Inc.Lateral flow assay and device using magnetic particles
US200700264219 Feb 20061 Feb 2007Caliper Life Sciences, Inc.Method and apparatus for generating thermal melting curves in a microfluidic device
US200700424412 May 200622 Feb 2007Bioscale, Inc.Method and apparatus for detecting estradiol and metabolites thereof using an acoustic device
US2007009290114 Nov 200626 Apr 2007The Government Of The Us, As Represented By The Secretary Of The NavyAutomated sample-to-microarray system
US2007009860018 Sep 20063 May 2007Clinical Micro Sensors, Inc.Devices and methods for biochip multiplexing
US2007009920025 Apr 20063 May 2007Caliper Life Sciences, Inc.High throughput mobility shift
US200701046174 Nov 200510 May 2007Advanced Biotechnologies LimitedCapped tubes
US2007015489530 Dec 20055 Jul 2007Caliper Life Sciences, Inc.Multi-assay microfluidic chips
US2007017714726 Mar 20072 Aug 2007Caliper Life Sciences, Inc.Microfluidic devices for electrophoretic analysis of materials
US2007017860722 Mar 20072 Aug 2007Prober James MMicroparticle-based methods and systems and applications thereof
US200701844632 Oct 20069 Aug 2007Caliper Life Sciences, Inc.Microfluidic device for purifying a biological component using magnetic beads
US2007018454711 Oct 20069 Aug 2007Kalyan HandiquePolynucleotide sample preparation device
US2007019623828 Dec 200623 Aug 2007Caliper Life Sciences, Inc.Integrated dissolution processing and sample transfer system
US200701998214 Oct 200630 Aug 2007Chow Andrea WAutomated two-dimensional gel electrophoresis
US2007021555422 Jul 200520 Sep 2007Kreuwel Hermannus J MDevice And Method For Separating, Mixing And Concentrating Magnetic Particles With A Fluid And Use Thereof In Purification Methods
US2007021845920 Sep 200420 Sep 2007Miller Benjamin LDiagnostic System For Otolaryngologic Pathogens And Use Thereof
US200702312132 Oct 20064 Oct 2007Nanyang PolytechnicSmart nano-integrated system assembly
US2007026147918 May 200715 Nov 2007Caliper Technologies, Corp.Methods and Systems for Monitoring Molecular Interactions
US200702698617 Dec 200622 Nov 2007Allergan Inc., Allergan Botox LimitedSoluble recombinant botulinum toxin proteins
US2007029294126 Mar 200720 Dec 2007Handylab, Inc.Integrated system for processing microfluidic samples, and method of using the same
US2008000077416 Apr 20073 Jan 2008Caliper Life Sciences, Inc.Method for modifying the concentration of reactants in a microfluidic device
US2008005080430 Oct 200728 Feb 2008Kalyan HandiqueMoving microdroplets in a microfluidic device
US200800569485 Sep 20076 Mar 2008Canon U.S. Life Sciences, Inc.Chip and cartridge design configuration for performing micro-fluidic assays
US2008007563421 Sep 200627 Mar 2008Abbott LaboratoriesSpecimen sample rack
US2008009024417 Oct 200717 Apr 2008Caliper Life Sciences, Inc.Methods of detecting low copy nucleic acids
US2008009567321 Oct 200724 Apr 2008Lin XuMicroplate with fewer peripheral artifacts
US200801189877 Sep 200722 May 2008Authentix, Inc.Microfluidic Device for Identification, Quantification, and Authentication of Latent Markers
US2008012472329 Jun 200729 May 2008Canon U.S. Life Sciences, Inc.Combined thermal devices for thermal cycling
US2008014984014 Nov 200726 Jun 2008Kalyan HandiqueFluorescence Detector for Microfluidic Diagnostic System
US2008016060114 Nov 20073 Jul 2008Kalyan HandiqueHeater Unit for Microfluidic Diagnostic System
US2008018230114 Nov 200731 Jul 2008Kalyan HandiqueMicrofluidic system for amplifying and detecting polynucleotides in parallel
US2008019225415 Oct 200714 Aug 2008Samsung Electronics Co., Ltd.System and method for detecting fluorescence in microfluidic chip
US200802479144 Apr 20089 Oct 2008Ted Carl EdensSample Preparation System And Method for Processing Clinical Specimens
US200802622133 May 200523 Oct 2008Betty WuProcessing Polynucleotide-Containing Samples
US2009004771314 Nov 200719 Feb 2009Kalyan HandiqueMicrofluidic Cartridge and Method of Making Same
US2009012997814 Jul 200821 May 2009Handylab, Inc.Reagent holder, and kits containing same
US2009013071926 Sep 200821 May 2009Handylab, Inc.Microfluidic Cartridge
US2009013074514 Jul 200821 May 2009Handylab, Inc.Integrated Apparatus for Performing Nucleic Acid Extraction and Diagnostic Testing on Multiple Biological Samples
US2009013165011 Jul 200821 May 2009Handylab, Inc.Polynucleotide Capture Materials, and Methods of Using Same
US2009013406923 Jul 200828 May 2009Handylab, Inc.Integrated Heater and Magnetic Separator
US2009013638523 Jul 200828 May 2009Handylab, Inc.Reagent Tube
US2009013638623 Jul 200828 May 2009Handylab, Inc.Rack for Sample Tubes and Reagent Holders
US2009015512317 Sep 200818 Jun 2009Handylab, Inc.Automated Pipetting Apparatus Having a Combined Liquid Pump and Pipette Head System
US2009022105914 Jul 20083 Sep 2009Handylab, Inc.Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US2009022392527 Mar 200910 Sep 2009Morse Jeffrey DChemical microreactor and method thereof
USD24970617 Dec 197626 Sep 1978Eastman Kodak CompanySample cup tray for chemical analysis of biological fluids
USD25215714 Apr 197719 Jun 1979Warner-Lambert CompanyDiagnostic device for measuring biochemical characteristics of microorganisms and the like
USD25234112 May 197710 Jul 1979Ryder International CorporationTesting tray
USD25468725 Jan 19798 Apr 1980Mcdonnell Douglas CorporationBiochemical card for use with an automated microbial identification machine
USD2610335 Feb 197929 Sep 1981American Optical CorporationBilirubin concentration analyzer
USD2611735 Feb 19796 Oct 1981American Optical CorporationBilirubinometer
USD27981719 Jul 198223 Jul 1985Daryl Laboratories, Inc.Immunoassay test slide
USD28847821 Jun 198424 Feb 1987Sentech Medical CorporationClinical chemistry analyzer
USD29273527 Apr 198410 Nov 1987A/S NuncTube for the immunological adsorption analysis
USD3022943 Oct 198618 Jul 1989Biotrack, Inc.Reagent cartridge for blood analysis
USD31041317 Dec 19874 Sep 1990Miles Inc.Sample processor
USD32442620 Oct 19893 Mar 1992Pacific Biotech, Inc.Reaction unit for use in analyzing biological fluids
USD32813512 Jan 199021 Jul 1992Pacific Biotech, Inc.Reaction unit for use in analyzing biological fluids
USD32879419 Jul 198918 Aug 1992Pb Diagnostic Systems, Inc.Diagnostic instrument or similar article
USD33352223 Jul 199123 Feb 1993P B Diagnostic Systems, Inc.Sample tube holder
USD3382753 Nov 198910 Aug 1993Bayer Diagnostics, GmbHCombined clinical-chemical analyzer evaluation unit and work station
USD34747827 Apr 199231 May 1994Hybaid Ltd.Laboratory instrument for handling bimolecular samples
USD3514757 Jul 199211 Oct 1994 Skin patch for testing allergic reactions
USD35191325 Feb 199325 Oct 1994Diametrics Medical, Inc.Disposable electrochemical measurement cartridge for a portable medical analyzer
USD3661163 Nov 19949 Jan 1996 Electrical box for storing dental wax
USD3787821 Mar 19968 Apr 1997Johnson & Johnson Clinical Diagnostics, Inc.Processor for nucleic acid detection
USD38234613 Oct 199512 Aug 1997Roche Diagnostic Systems, Inc.Vessel holder
USD38264717 Jan 199619 Aug 1997Biomerieux Vitek, Inc.Biochemical test card
USD39995924 Jan 199720 Oct 1998Abbott LaboratoriesHousing for a device for measuring the concentration of an analyte in a sample of blood
USD4133915 Feb 199831 Aug 1999Bayer CorporationTest tube sample rack
USD41367726 Nov 19977 Sep 1999Bayer CorporationSample tube rack
USD4170092 Mar 199823 Nov 1999Bayer CorporationSample tube rack
USD42074710 Jul 199815 Feb 2000Bayer CorporationSample tube rack
USD42113015 Jun 199822 Feb 2000Bayer CorporationSample tube rack
USD42165318 Nov 199614 Mar 2000Tekmar CompanyHousing for a laboratory instrument
USD4284976 Mar 199818 Jul 2000Bayer CorporationTest tube sample rack
USD43375918 Jun 199814 Nov 2000Bayer CorporationVial carrier
USD43831121 Jan 200027 Feb 2001Matsushita Electric Industrial Co.,Ltd.Strip for blood test
USD43863221 Dec 19996 Mar 2001Compucyte CorporationMulti-well reagent cartridge for treating a sample
USD43863321 Dec 19996 Mar 2001Compucyte CorporationReagent cartridge for treating a sample
USD44630627 Sep 20007 Aug 2001Matsushita Electric Industrial Co., Ltd.Medical information communication apparatus
USD46190625 Oct 199920 Aug 2002Tuan Hung PhamDiagnostic test card
USD46303111 Oct 200017 Sep 2002Aclara Biosciences, Inc.Microvolume sample plate
USD46734815 Oct 200117 Dec 2002Kimberly-Clark Worldwide, Inc.Diagnostic test carrier
USD46734928 Sep 200117 Dec 2002Orasure Technologies, Inc.Analyzer
USD46843721 Nov 20007 Jan 2003Acon Laboratories, Inc.Test platform
USD47059510 Oct 200118 Feb 2003Andrea CrisantiAssay device
USD4723245 Apr 200225 Mar 2003Charles River Laboratories, Inc.Cuvette
USD47427915 May 20026 May 2003Monogen, Inc.Specimen processing instrument
USD47428011 Sep 20026 May 2003Orasure Technologies, Inc.Analyzer
USD48081411 Jun 200214 Oct 2003Diversa CorporationGigamatrix holding tray
USD4827964 Mar 200225 Nov 2003Sysmex CorporationSample analyzer
USD48498920 Sep 20026 Jan 2004Dade Behring Inc.Multi-well liquid container
USD49127213 Dec 20028 Jun 2004Immunivest CorporationAutoprep instrument
USD49127319 Dec 20028 Jun 20043M Innovative Properties CompanyHybridization cartridge
USD4912769 Dec 20028 Jun 2004Babette LangillePlastic diagnostic card
USD4958052 Jul 20017 Sep 2004Umedik, Inc.Assay device
USD49981322 Aug 200314 Dec 2004As.Pire Bioresearch Inc.Assay testing device
USD50014210 Oct 200121 Dec 2004Andrea CrisantiAssay device
USD50899924 Jul 200330 Aug 2005Biomerieux, Inc.Sample testing machine
USD51215511 Mar 200229 Nov 2005Techno Medica Co., Ltd.Automatic blood sampling tube preparation apparatus
USD51570730 Dec 200321 Feb 2006Matsushita Electric Industrial Co., Ltd.Fluorescent reader
USD5162219 Sep 200228 Feb 2006Meso Scale Technologies, Llc.Diagnostic instrument
USD51755416 Aug 200421 Mar 2006Seiko Epson CorporationFilm scanner
USD52315321 Dec 200413 Jun 2006Hitachi High-Technologies CorporationMain part for immunity analysis machine
USD52821529 Mar 200412 Sep 2006Biacore AbChip carrier for biosensor
USD5313213 Oct 200531 Oct 2006Akubio LimitedCartridge
USD5342804 May 200526 Dec 2006Abbott LaboratoriesReagent carrier for use in an automated analyzer
USD53540323 Aug 200516 Jan 2007Fuji Photo Film Co., Ltd.Component extractor for biochemistry
USD53795120 Apr 20066 Mar 2007Sanyo Electric Co., Ltd.Gene amplification apparatus
USD5384366 Mar 200613 Mar 2007Steris Inc.Reprocessor for decontaminating medical, dental and veterinary instruments and articles
USD54884115 Oct 200414 Aug 2007Microsulis, LtdElectrical equipment for ablative treatment
USD54982714 Mar 200628 Aug 2007Horiba, Ltd.Blood analyzer
USD5540693 May 200630 Oct 2007Data I/O CorporationProcessing apparatus
USD5540703 May 200630 Oct 2007Data I/O CorporationProcessing apparatus
USD55691420 Apr 20064 Dec 2007Sanyo Electric Co., Ltd.Gene amplification apparatus
USD55999527 Mar 200615 Jan 2008Handylab, Inc.Controller cartridge for a diagnostic instrument
USD56629127 Mar 20068 Apr 2008Handylab, Inc.Microfluidic cartridge
USD56952627 Mar 200620 May 2008Handylab, Inc.Molecular diagnostic instrument
USD59631213 Jun 200814 Jul 2009Csp Technologies, Inc.Vial rack
USD598566 *12 Aug 200818 Aug 2009Diagenode Societe AnonymeMedical instrument for laboratory use
USD632799 *18 Oct 200815 Feb 2011The Automation PartnershipCell dispenser
CA2294819C2 Jul 19985 Apr 2005The Regents Of The University Of MichiganThermal microvalves
DE19929734B429 Jun 19996 Oct 2005Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo AltoMikrofluidvorrichtung
EP0766256B129 Sep 19951 Dec 1999SGS-THOMSON MICROELECTRONICS S.r.l.Voltage regulator for semiconductor non-volatile electrically programmable memory devices
FR2672301A1 Title not available
FR2795426A1 Title not available
JPS58212921A Title not available
Non-Patent Citations
Reference
1Bollet, C. et al., "A simple method for the isolation of chromosomal DNA from Gram positive or acid-fast bacteria", Nucleic Acids Research, vol. 19, No. 8 (1991), p. 1955.
2Brahmassandra, et al., On-Chip DNA Detection in Microfabricated Separation Systems, Part of the SPIE Conference on Microfludic Devices and Systems, 1998, Santa Clara, California, vol. 3515, pp. 242-251.
3Breadmore, M.C. et al., "Microchip-Based Purification of DNA from Biological Samples", Anal. Chem., vol. 75 (2003), pp. 1880-1886.
4Brody, et al., Diffusion-Based Extraction in a Microfabricated Device, Sensors and Actuators Elsevier, 1997, vol. A58, No. 1, pp. 13-18.
5Broyles, et al., "Sample Filtration, Concentration, and Separation Integrated on Microfluidic Devices" Analytical Chemistry (American Chemical Society), vol. 75 No. 11: pp. 2761-2767.
6Burns et al., "An Integrated Nanoliter DNA Analysis Device", Science 282:484-487 (1998).
7Carlen et al., "Paraffin Actuated Surface Micromachined Valve," in IEEE MEMS 2000 Conference, p. 381-385, Miyazaki, Japan, Jan. 2000.
8Chung, Y. et al., "Microfluidic chip for high efficiency DNA extraction", Miniaturisation for Chemistry, Biology & Bioengineering, vol. 4, No. 2 (Apr. 2004), pp. 141-147.
9Handique K., et al., On-Chip Thermopneumatic Pressure for Discrete Drop Pumping, Analytical Chemistry, American Chemical Society, Apr. 15, 2001, vol. 73, No. 8, 1831-1838.
10Handique, K. et al, "Microflidic flow control using selective hydrophobic patterning", SPIE, vol. 3224, pp. 185-194 (1997).
11Handique, K. et al., "Mathematical Modeling of Drop Mixing in a Slit-Type Micochannel", J. Micromech. Microeng., 11:548-554 (2001).
12Handique, K. et al., "Nanoliter Liquid Metering in Microchannels Using Hydrophobic Patterns", Anal. Chem., 72:4100-4109 (2000).
13Handique, K. et al., "Nanoliter-volume discrete drop injection and pumping in microfabricated chemical analysis systems", Solid-State Sensor and Actuator Workshop (Hilton Head, South Carolina, Jun. 8-11, 1998) pp. 346-349.
14He, et al., Microfabricated Filters for Microfludic Analytical Systems, Analytical Chemistry, American Chemical Society, 1999, vol. 71, No. 7, pp. 1464-1468.
15Ibrahim, et al., Real-Time Microchip PCR for Detecting Single-Base Differences in Viral and Human DNA, Analytical Chemistry, American Chemical Society, 1998, vol. 70, No. 9, pp. 2013-2017.
16Khandurina, et al., Microfabricated Porous Membrane Structure for Sample Concentraction and Electrophoretic Analysis, Analytical Chemistry American Chemical Society, 1999, vol. 71, No. 9, pp. 1815-1819.
17Kopp, et al., Chemical Amplification: Continuous-Flow PCR on a Chip, www.sciencemag.org, 1998, vol. 280, pp. 1046-1048.
18Kutter, et al., Solid Phase Extraction on Microfludic Devices, J. Microcolumn Separations, John Wiley & Sons, Inc., 2000, vol. 12, No. 2, pp. 93-97.
19Lagally, et al., Single-Molecule DNA Amplification and Analysis in an Integrated Microfluidic Device, Analytical Chemistry, American Chemical Society, 2001, vol. 73, No. 3 pp. 565-570.
20Livache, T. et al., "Polypyrrole DNA chip on a Silicon Device: Example of Hepatitis C Virus Genotyping", Analytical Biochemistry, vol. 255 (1998), pp. 188-194.
21Northrup, et al., A Miniature Analytical Instrument for Nucleic Acids Based on Micromachined Silicon Reaction Chambers, Analytical Chemistry, American Chemical Society, 1998, vol. 70, No. 5, pp. 918-922.
22Oleschuk, et al., Trapping of Bead-Based Reagents within Microfluidic Systems,: On-Chip Solid-Phase Extraction and Electrochromatography, Analytical Chemistry, American Chemical Society, 2000, vol. 72, No. 3, pp. 585-590.
23Orchid BioSciences, Inc., www.orchid.com, Jul. 6, 2001.
24Roche, et al. "Ectodermal commitment of insulin-producing cells derived from mouse embryonic stem cells" Faseb J (2005) 19: 1341-1343.
25Ross, et al., Analysis of DNA Fragments from Conventional and Microfabricated PCR Devices Using Delayed Extraction MALDI-TOF Mass Spectrometry, Analytical Chemistry, American Chemical Society, 1998, vol. 70, No. 10, pp. 2067-2073.
26Shoffner, M. A. et al., Chip PCR.I. Surface Passivation of Microfabricated Silicon-Glass Chips for PCR, Nucleic Acids Research, Oxford University Press, 1996, vol. 24, No. 2, 375-379.
27Smith, K. et al., "Comparison of Commercial DNA Extraction Kits for Extraction of Bacterial Genomic DNA from Whole-Blood Samples", Journal of Clinical Microbiology, vol. 41, No. 6 (Jun. 2003), pp. 2440-2443.
28Waters, et al., Microchip Device for Cell Lysis, Multiplex PCR Amplification, and Electrophoretic Sizing, Analytical Chemistry, American Chemical Society, 1998, vol. 70, No. 1, pp. 158-162.
29Weigl, et al., Microfluidic Diffusion-Based Separation and Detection, www.sciencemag.org, 1999, vol. 283, pp. 346-347.
30Yoza, Brandon et al., DNA extraction using bacterial magnetic particles modified with hyperbranched polyamidoamine dendrimer, Mar. 20, 2003, vol. 101, No. 3, 219-228.
31Yoza, et al., "Fully Automated DNA Extraction fro Blood Using Magnetic Particles Modified with a Hyperbranched Polyamidomine Dendrimer", Journal of Bioscience and Bioengineering, 95(1):21-26, 2003.
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US953508213 Mar 20133 Jan 2017Abbott LaboratoriesMethods and apparatus to agitate a liquid
US97894549 Nov 201617 Oct 2017Abbott LaboratoriesMethods and apparatus to agitate a liquid
USD737993 *13 Aug 20131 Sep 2015Access Medical Systems, Ltd.Medical test cartridge
USD759268 *28 Aug 201514 Jun 2016Access Medical Systems, Ltd.Medical test cartridge
USD782060 *21 Dec 201521 Mar 2017Abbott LaboratoriesReagent kit with multiple bottles
USD782061 *21 Dec 201521 Mar 2017Abbott LaboratoriesReagent kit with multiple bottles
USD782062 *21 Dec 201521 Mar 2017Abbott LaboratoriesReagent kit with multiple bottles
USD782063 *21 Dec 201521 Mar 2017Abbott LaboratoriesReagent kit with multiple bottles
Classifications
U.S. ClassificationD24/227