US9279140B2 - Personal care products with visual indicator of vaginitis - Google Patents
Personal care products with visual indicator of vaginitis Download PDFInfo
- Publication number
- US9279140B2 US9279140B2 US13/975,545 US201313975545A US9279140B2 US 9279140 B2 US9279140 B2 US 9279140B2 US 201313975545 A US201313975545 A US 201313975545A US 9279140 B2 US9279140 B2 US 9279140B2
- Authority
- US
- United States
- Prior art keywords
- indicator
- dye
- personal care
- pad
- care product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/56—Wetness-indicators or colourants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/528—Atypical element structures, e.g. gloves, rods, tampons, toilet paper
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/84—Accessories, not otherwise provided for, for absorbent pads
- A61F2013/8473—Accessories, not otherwise provided for, for absorbent pads for diagnostic purposes
Definitions
- the invention concerns processes and products for the indication of infection such as in vaginitis.
- Vaginal infections are the most common women's health problem, and commonly or medically referred to as vaginitis. Vaginal infections are the most frequent reason American women see their doctors, and account for more than 10 million office visits per year. Vaginal infection (“vaginitis”), for example, exists in three primary forms, i.e., bacterial vaginosis, candidal vaginitis (“yeast”), and trichomonas vaginitis (“trich”). The most prevalent type of infection is bacterial vaginosis, affecting up to 40 to 50% of American women of childbearing age.
- vaginal infection The most characteristic symptoms of vaginal infection are discharge, odor, irritation, and elevation of pH and amine(s) level.
- Various mono- and di-amines are produced by anaerobic bacteria, and result in odor in the vaginal fluid with bacterial vaginosis.
- vaginitis Various techniques have been developed in an attempt to rapidly diagnose the forms of vaginitis. For example, microbiological techniques have been utilized to identify “clue cells” (vaginal epithelial cells with adherent surface bacteria). Conventional techniques for confirming the presence of “clue cells”, however, are often complicated and slow. Likewise, techniques have been utilized that detect an elevated pH level in an infected sample. Unfortunately, conventional techniques for detecting an elevated pH level are often misleading due to other factors, such as the use of antimicrobials and cervical discharge, which also cause an elevated pH. Several detection methods are known for amines, these methods, however, have complex multiple steps, require expensive instrumentation, or are time-consuming.
- the typical personal care product has a body side liner and a baffle and may have an absorbent pad there between.
- An indicator strip may be placed in the product.
- the indicator has an amine sensitive dye deposit that may be near at least one end.
- the indicator may be in the target area only or may extend from the target area and/or the middle of pad.
- the indicator may extend from just below the liner to just above the baffle such that the dye deposit is visible to an unaided eye either from the liner side (body) or baffle side (garment).
- the dye changes color in the presence of amines which are characteristic of infection, thus alerting the user to the possibility of infection.
- a feminine hygiene pad having such an indicator may be useful in the diagnosis of vaginitis.
- the indicator is useful in diagnosing vaginitis by placing it into tampons, swabs, removable patches, reusable underwear, and the like.
- Also disclosed is a method of providing a system for visually indicating the presence of amines that are characteristic of vaginitis the method.
- the method includes the steps of providing a feminine hygiene pad having an indicator, providing instructions to enable a user to properly place the pad, providing instructions to enable a user to visually examine the indicator at an appropriate time, providing instructions to enable a user to visually interpret changes in the indicator, so that a user is enabled to utilize the system to visually indicate the presence of amines that are characteristic of vaginitis.
- FIG. 1 is a broken away drawing of a feminine hygiene product.
- FIG. 2 is a drawing of an absorbent underpant.
- FIG. 3 is a drawing of an indicator in a tampon.
- FIG. 4 is a drawing of an indicator strip.
- FIGS. 5A and 5B are plan (a) and cross-sectional (b) views of a feminine hygiene pad having an indicator strip wherein only one end of the strip has dye.
- FIGS. 6A and 6B are plan (a) and cross-sectional (b) views of a feminine hygiene pad having an indicator strip wherein both ends of the strip have dye.
- FIGS. 7A and 7B are plan (a) and cross-sectional (b) views of a feminine hygiene pad having an indicator in the middle of pad liner.
- FIG. 8 is a drawing of a diaper having an indicator in the target area.
- the present invention involves the visual indication of infection in vaginitis.
- Such an indicator may be placed in personal care products, e.g.; absorbent underpants and feminine hygiene products.
- Bacterial vaginosis is the most common vaginal infection. Bacterial vaginosis (BV) affects up to 40 to 50% of American women of childbearing age, and is caused by increased anaerobic bacteria in the vagina that leads to characteristic amine production and odor. Various amines are produced by anaerobic bacteria, and these amines are released into the vaginal fluid in bacterial vaginosis (BV).
- trichomonas is a common sexually transmitted disease (STD) that affects 2 to 3 million Americans yearly. It is caused by a single-celled protozoan parasite called trichomonas vaginalis . Trichomoniasis is primarily an infection of the urogenital tract; the urethra is the most common site of infection in men, and the vagina is the most common site of infection in women. Though trichomoniasis occurs in men, they have no symptoms, whereas in women symptoms usually appear within four to 20 days of exposure.
- One of the diagnostic criteria for trichomonas is the detection of a fishy amine odor.
- Vaginal yeast infection or vulvovaginal candidiasis is the second most common cause of vaginitis in the US and the most common cause in Europe. Doctors estimate that approximately 75 percent of all women will experience at least one symptomatic yeast infection during their lifetimes, and approximately 5 percent of women will have recurrent episodes.
- Candida albicans is the infecting agent in 80 to 90 percent of the yeast infected patients, and the doctor usually diagnoses yeast infection through microscopic examination of vaginal secretions for evidence of yeast forms such as candida albicans . Both pH and amine odors are not significantly changed in yeast vaginitis compared to normal women.
- bacterial vaginosis and trichomoniasis produce tell-tale amine odors.
- bacterial vaginosis several members of anaerobic bacteria, prevotella, bacteroides, mobiluncus , and peptococcus , are present in large numbers in the vagina. Some of these organisms produce metabolic products such as amines, including trimethyl amine, putrescine, cadaverine, and tyramine which are responsible for the odor noticed by the affected patients.
- a “Whiff test” is routinely conducted for amine odors where enhanced odor is generated by adding strong alkali to the sample, however, this test must be professionally performed and the use of strong alkali is not applicable to personal care products due to the caustic nature of the chemical.
- an amine sensitive chemichromic dye can be used to indicate the presence of amines in vaginal odor and thus to signal a possible infection.
- three dyes with different color spectrum were identified for the indication of amine odors, though others with similar characteristics regarding their reaction to amines may also be used.
- One class of chemichromic dyes that is particularly useful is arylmethane dyes, such as diarylmethanes, triarylmethanes, and the like.
- Triarylmethane dyes may have the following general structure:
- R, R′, and R′′ are independently selected from substituted and unsubstituted aryl groups, such as phenyl, naphthyl, anthracenyl, etc.
- the aryl groups may, for example, be substituted with functional groups, such as amino, hydroxyl, carbonyl, carboxyl, sulfonic, alkyl, and/or other known functional groups.
- the amino group of the amine e.g., ammonia, diamines, and/or tertiary amines
- reacts with the central carbon atom of the dye reacts with the central carbon atom of the dye.
- the addition of the amino group causes the dye to undergo a change in color.
- An example of the resulting structure is set forth below:
- pararosanilin also known as “basic fuchsin” or “magenta 0” and analogs thereof, such as rosanilin (“magenta I”), magenta II, new fuchsin (“magenta III”), methyl violet 2B, methyl violet 6B, methyl violet 10B (“crystal violet”), methyl green, ethyl green, acid fuchsin, and so forth.
- Pararosanilin shifts from a red color to colorless (i.e., white) upon reaction with an amine.
- Pararosanilin contains three phenylamine groups (i.e., amino-substituted aryl groups). Specifically, the structure of the structure of pararosanilin is set forth below:
- triarylmethane dyes may be formed by converting a leuco base to a colorless carbinol and then treating the carbinol with an acid to oxidize the carbinol and form the dye.
- pararosanilin may be derived by reacting the carbinol form of pararosanilin (“pararosaniline base”) with an acid, such as, but not limited to, sulfonic acids, phosphoric acids, hydrochloric acid, and so forth.
- pararosanilin may be derived by reacting the carbinol form of pararosanilin (“pararosaniline base”) with an acid, such as, but not limited to, sulfonic acids, phosphoric acids, hydrochloric acid, and so forth.
- the carbinol form of pararosanilin is set forth below.
- alpha-naphtholbenzein is alpha-naphtholbenzein and analogs thereof.
- Alpha-naphtholbenzein turns from an orange/red color to a gray/black color upon reaction with an amine.
- Alpha-naphtholbenzein contains a hydroxyl-substituted naphthyl group, a carbonyl-substituted naphthyl group, and a phenyl group.
- the structure of alpha-naphtholbenzein is set forth below:
- naphthocrome green turns from a pale yellow color to a blue/green color upon reaction with an amine. Similar to alpha-naphtholbenzein, naphthocrome green contains a hydroxyl-substituted naphthyl group, a carbonyl-substituted naphthyl group, and a phenyl group. However, each naphthyl group is also substituted with a sodium carboxyl. Specifically, the structure of naphthocrome green is set forth below:
- diarylmethanes may also be used.
- One example of such a diarylmethane is 4,4′-bis(dimethylamino)benzhydrol (also known as “Michler's hydrol”), which has the following structure:
- Still other examples include analogs of Michler's hydrol, such as Michler's hydrol leucobenzotriazole, Michler's hydrol leucomorpholine, Michler's hydrol leucobenzenesulfonamide, and so forth, as well as other diarylmethanes, such as malachite green leuco, malachite green carbinol, sodium 2,6-dichloroindopheno-late, rhodamine lactam, crystal violet lactone, and crystal violet leuco.
- Michler's hydrol such as Michler's hydrol leucobenzotriazole, Michler's hydrol leucomorpholine, Michler's hydrol leucobenzenesulfonamide, and so forth
- other diarylmethanes such as malachite green leuco, malachite green carbinol, sodium 2,6-dichloroindopheno-late, rhodamine lactam, crystal violet lac
- TMA trimethylamine
- putrescine (1,4-diaminobutane or 1,4 DAB
- cadaverine (1,5-diamino pentane or 1,5 DAP
- ANB alpha-naphtholbenzein
- the indicator may be a removable patch.
- the indicator may be placed, for example, in every product in a package containing multiple products or may be placed in every second, third or fifth product in the package, etcetera.
- biological sample generally refers to a biological material suspected of containing the analyte.
- the biological sample may be obtained or derived from any biological source, such as a physiological fluid, including, blood, menses, interstitial fluid, saliva, ocular lens fluid, cerebral spinal fluid, sweat, urine, milk, ascites fluid, mucous, synovial fluid, peritoneal fluid, vaginal fluid, amniotic fluid, and so forth.
- Feminine hygiene products include, for example, the pad shown in FIG. 1 .
- This pad 10 has a liquid impervious baffle 12 on the side away from the wearer.
- the baffle 12 is often made from a film like a polyethylene or polypropylene film and is transparent or translucent.
- the layer closest to the wearer is the body side liner 14 and is a liquid pervious layer that is preferably soft and absorbent. Between the baffle 12 and liner 14 there may be a number of layers for different purposes, such as an absorbent core 16 designed to hold the majority of any liquid discharge.
- Other optional layers include transfer delay layers 18 , and tissue wraps (not shown).
- Absorbent underpants 20 as shown in FIG. 2 have a baffle 22 , liner 24 and absorbent core (not shown).
- a further discussion regarding absorbent underpants may be found, for example, in U.S. Pat. Nos. 6,240,569 and 6,367,089 which are incorporated herein in their entirety by reference thereto for all purposes.
- a tampon as shown in FIG. 3 may also contain the indicator 30 .
- Tampons have the general structure as described in U.S. Pat. Nos. 3,520,302 and 3,683,912 which are incorporated herein in their entirety by reference thereto for all purposes.
- the generally elongate shape of a tampon typically has an absorbent body 26 and a withdrawal string 28 . Additional structural features may also be present.
- the indicator may be placed in a standard cotton swab so that it is visible on the end.
- the swab may have cotton at one or both ends.
- the dye portion of the indicator may be between the ends of the swab so that amines contacted by the ends of the swab will move toward the dye located in a more visible portion of the swab and thus be more easily observed by a user.
- the indicator 30 contains a porous membrane 32 that acts as a fluidic medium.
- the porous membrane 32 may be made from any of a variety of materials through which the test sample is capable of passing.
- the materials used to form the porous membrane 32 may include, but are not limited to, natural, synthetic, or naturally occurring materials that are synthetically modified, such as polysaccharides (e.g., cellulose materials such as paper and cellulose derivatives, such as cellulose acetate and nitrocellulose); polyether sulfone; polyethylene; nylon; polyvinylidene fluoride (PVDF); polyester; polypropylene; silica; inorganic materials, such as deactivated alumina, diatomaceous earth, MgSO 4 , or other inorganic finely divided material uniformly dispersed in a porous polymer matrix, with polymers such as vinyl chloride, vinyl chloride-propylene copolymer, and vinyl chloride-vinyl acetate copolymer; cloth, both naturally occurring (e.g., cotton) and synthetic (e.g., nylon or rayon); porous gels, such as silica gel, agarose, dextran, and gelatin; polymeric films, such as polyacrylamide; and
- the porous membrane 32 is formed from nitrocellulose and/or polyether sulfone materials.
- nitrocellulose refers to nitric acid esters of cellulose, which may be nitrocellulose alone, or a mixed ester of nitric acid and other acids, such as aliphatic carboxylic acids having from 1 to 7 carbon atoms.
- the indicator 30 may also contain an absorbent pad 34 .
- the absorbent pad 34 generally receives fluid that has migrated through the entire porous membrane 32 .
- the absorbent pad 34 may assist in promoting capillary action and fluid flow through the membrane 32 .
- the indicator 30 contains a detection zone 36 that may generally provide any number of distinct detection regions so that a user may better determine the concentration of a particular analyte within a test sample. Each region may contain a deposit of the chemichromic dye, or may contain different dyes for reacting with different types of amines.
- the detection zone 36 may, for example, include two or more distinct detection regions (e.g., lines, dots, etc.). The detection regions may be disposed in the form of lines in a direction that is substantially perpendicular to the flow of the test sample through the indicator 30 . In some embodiments the detection regions may be disposed in the form of lines in a direction that is substantially parallel to the flow of fluid through the indicator 30 .
- the size of the dye deposit in the detection zone 36 may be varied, with the sole requirement being that it be of sufficient size and quantity to be seen by the unaided eye.
- Dye deposits as small as a few millimeters in area to as large as necessary may be produced, with the most likely sizes for personal care products being between 0.25 cm 2 and 5 cm 2 , more desirably between about 0.5 cm 2 and 3 cm 2 , still more desirably between 1 cm 2 and 2 cm 2 .
- the indicator 30 may be of any size appropriate to the personal care product in which it is to be used. In particular, a size of between about 0.25 and 3 centimeters in width and about 8 to 25 cm in length may be used. More particularly a width of about 1 to 2 cm and length of about 10 to 15 cm may be appropriate for many feminine hygiene pad products. Still more particularly a width of about 1.3 cm and a length of about 12 cm may be appropriate.
- the indicator 30 may be placed below the liner 14 in one area of the pad and extend to just above the baffle 12 . In this location adjacent to the liner the indicator may be contacted directly by any discharge, yet is still appropriately located so that it may be seen by the user upon removal. It should be noted that the indicator may be located in the “target area” (the area where discharges generally impact upon the product). The important factor is that it be visible to a user after amine exposure. In use, upon receipt of a discharge, the fluid will pass through the liner 14 and come in contact with the indicator 30 .
- the fluid will travel along the indicator 30 and eventually contact the chemichromic dye(s) in the detection zone 36 . This will cause a color change if there are amines present. Upon removal of the pad, the detection zone 36 will be visible through the baffle 12 . A color change will alert the user to the possibility of infection and the need to seek treatment.
- the indicator 30 may be placed below the liner 14 in the target area and both ends of the indicator 30 may extend to just above the baffle 12 . Again, the indicator 30 may be contacted by any discharge in the target area, which will travel along the indicator 30 to the detection zones 36 and, if amines are present, cause a color change visible to the user through the baffle 12 .
- the indicator 30 with dye in the detection zone 36 may be inserted just below the liner 14 in, for example, the target area. In this position the indicator will change color when contacted with amine containing discharges and be visible through the liner when the product is removed from the body.
- the detection zone 36 may be the size of the entire indicator 30 .
- the indicator may be a removable patch that may be positioned by a user in a product such as a feminine hygiene pad.
- the patch may be held in place with any appropriate means such as by adhesive, hook and loop fastener, and so forth.
- FIG. 8 shows the indicator 30 located in the target area of a diaper 38 .
- This indicator may be of the removable patch type or may be permanently mounted in the diaper 38 .
- the dye may be applied directly to the membrane 32 or first formed into a solution prior to application.
- Various solvents may be utilized to form the solution, such as, but not limited to, acetonitrile, dimethylsulfoxide (DMSO), ethyl alcohol, dimethylformamide (DMF), and other polar organic solvents.
- the amount of the dye in the solution may range from about 0.001 to about 10 milligram per milliliter of solvent, and in some embodiments, from about 0.01 to about 0.1 milligrams per milliliter of solvent.
- the dye solution may be coated onto the porous membrane 32 using known methods and then dried.
- the dye may be coated onto the substrate layer by the dip and squeeze method, which entails dipping the layer into a solution having the absorbent and binder, squeezing out the excess, and drying.
- the dye may alternatively be applied to the substrate by placing a few drops of the dye solution on the desired area and allowing the substrate to air-dry, as for example.
- the dye concentration may be selectively controlled to provide the desired level of detection sensitivity; for example, higher concentrations may provide a higher level of detection sensitivity when low amine levels are suspected.
- Printing techniques like ink jet printing, rotogravure printing and other techniques known to those skilled in the art may suitable be used to apply the dye to the substrate.
- the dye may be applied, as indicated herein, in a pattern of circular dots. Many other sizes and patterns for the dye may be used, of course, including lettering such as “See your doctor” and the like.
- the issue is that the area of the dye in the product be visible by the unaided eye after the product is used. In this way the color change, from colored to colorless, from colorless to colored, or from one color to another color, will alert the user to the need to seek medical attention.
- a personal care product includes a visual indicator having a basic amine-sensitive, chemichromic dye, arranged such that said dye is observable to a user, said dye has either general formula (I) or (II)
- R is H, (NH 2 )C 6 H 4 — or C 6 H 5 —, R′ is
- Another aspect of the disclosure is method of visualizing bacterial vaginosis that includes the following steps:
- said amine-sensitive dye has either general formula (I) or (II).
- R is H, (NH 2 )C 6 H 4 — or C 6 H 5 —, R′ is
- a visual indicator was incorporated into a KOTEX LIGHTDAYS Ultra coverage (purse-paks, unscented) feminine hygiene pad as a small strip of tissue and demonstrated to be sensitive to the amine-based vaginal odors.
- ANB dye at a concentration of 50-5000 micrograms was coated onto a cellulose towel substrate and allowed to air dry, producing an orange color. Small strips (1 cm ⁇ 2 cm) of the towel were then inserted into the pad at one end under the body side liner. The orange colored strip was still quite visible.
- the pad was then insulted with 10 microliters of a 10 mg/ml TMA amine solution at a concentration of 100 micrograms placed in the target area of the pad, and then the pad was placed into a 1 quart, glass jar and sealed. The liquid amine did not directly touch the dye.
- the orange color of the cellulose strip rapidly changed color to a grey/black color, indicating the presence of amines and therefore serving as an alert signal for potential vaginitis.
- a visual indicator was incorporated into a KOTEX LIGHTDAYS Long (unscented) feminine hygiene pad as a small strip of nitrocellulosic material and demonstrated to be sensitive to the amine-based vaginal fluid.
- ANB dye at a concentration of 50-5000 micrograms was placed on the strip on one end in three relatively circular dots (not shown) with a diameter of about 7 mm and allowed to air dry, producing an orange color.
- a strip (1.3 cm ⁇ 8 cm) of the material was then inserted into the pad as shown in FIGS. 5A and 5B with the three dots on the end just above the baffle. The dots on the strip were visible through the baffle but the strip was not visible through the body side liner.
- the pad was then insulted with 200 microliters of a 1.5 mg/ml mixed amine (TMA, 1,5-DAP, 1,4-DAB, and Tyramine) solution placed in the target area of the pad.
- TMA 1.5 mg/ml mixed amine
- the orange color of the dye deposits changed color to a grey/black color after approximately ⁇ 5 minutes, indicating the presence of amines and therefore serving as an alert signal for potential vaginitis.
- the dots of dye changed color sequentially with the dot closest to the target area changing color first and the others following in order.
- This experiment demonstrates the potential application for the visual indicator to detect amines from the center of the pad and act as visual alert to the user.
- a visual indicator was incorporated into a KOTEX LIGHTDAYS Long (unscented) feminine hygiene pad as a small strip of nitrocellulosic material and demonstrated to be sensitive to the amine-based vaginal fluid.
- ANB dye at a concentration of 50-5000 micrograms was placed on the strip on both ends in three relatively circular dots with a diameter of about 7 mm and allowed to air dry, producing an orange color.
- a strip (1.3 cm ⁇ 8 cm) of the material was then inserted into the pad as shown in FIGS. 5A and 5B with the three dots on each end just above the baffle. The dots on the strip were visible through the baffle but the strip was not visible through the body side liner.
- the pad was then insulted with 200 microliters of a 1.5 mg/ml mixed amine (TMA, 1,5-DAP, 1,4-DAB) solution placed in the target area of the pad.
- TMA 1.5 mg/ml mixed amine
- the orange color of the dye deposits changed color to a grey/black color after approximately ⁇ 5 minutes, indicating the presence of amines and therefore serving as an alert signal for potential vaginitis.
- the dots of dye changed color sequentially with the dot closest to the target area changing color first and the others following in order.
- a visual indicator was incorporated into a KOTEX LIGHTDAYS Long (unscented) feminine hygiene pad as a small strip of nitrocellulosic material and demonstrated to be sensitive to the amine-based vaginal fluid.
- ANB dye at a concentration of 50-5000 micrograms was placed on the strip on both ends in three relatively circular dots with a diameter of about 7 mm and allowed to air dry, producing an orange color.
- a strip (1.3 cm ⁇ 8 cm) of the material having the three dots on each end (not shown) was then inserted into the pad with the ends just above the baffle as shown in FIG. 6B . The dots on the strip were visible through the baffle but the strip was not visible through the body side liner.
- the pad was then insulted with 200 microliters of normal vaginal secretion sample placed in the target area of the pad, and the solution was flowed from the center zone to the indicator zone by ⁇ 10 minutes.
- a visual indicator was incorporated into a KOTEX LIGHTDAYS Long (unscented) feminine hygiene pad as a small strip of nitrocellulosic material and demonstrated to be sensitive to the amine-based vaginal fluid.
- ANB dye at a concentration of 50-5000 micrograms was placed on the strip on both ends in three relatively circular dots with a diameter of about 7 mm and allowed to air dry, producing an orange color.
- a strip (1.3 cm ⁇ 8 cm) of the material having the three dots on each end (not shown) was then inserted into the pad with the ends just above the baffle as shown in FIG. 6B . The dots on the strip were visible through the baffle but the strip was not visible through the body side liner.
- the pad was then insulted with 200 microliters of vaginal secretion sample with spiked amines (1.5 mg/ml concentration of mixed amines TMA, 1,5-DAP, 1,4-DAB, and tyramine) placed in the target area of the pad.
- spiked amines 1.5 mg/ml concentration of mixed amines TMA, 1,5-DAP, 1,4-DAB, and tyramine
- the orange color of the dye deposits changed color to a grey/black color after approximately ⁇ 10 minutes, indicating the presence of amines and therefore serving as an alert signal for potential vaginitis.
- the dots of dye changed color sequentially with the dot closest to the target area changing color first and the others following in order.
- a visual indicator was incorporated into a KOTEX LIGHTDAYS Long (unscented) feminine hygiene pad as a small strip of nitrocellulosic material and demonstrated to be sensitive to the amine-based vaginal fluid.
- ANB dye at a concentration of 50-5000 micrograms was placed on the strip on both ends in three relatively circular dots with a diameter of about 7 mm and allowed to air dry, producing an orange color.
- a strip (1.3 cm ⁇ 8 cm) of the material having the three dots on each end (not shown) was then inserted into the pad with the ends just above the baffle as shown in FIGS. 6A and 6B . The dots on the strip were visible through the baffle but the strip was not visible through the body side liner.
- the pad was then insulted with 200 microliters of normal menses sample placed in the target area of the pad, and the solution was flowed from the center zone to the indicator zone by ⁇ 5 minutes.
- a visual indicator was incorporated into a KOTEX LIGHTDAYS Long (unscented) feminine hygiene pad as a small strip of nitrocellulosic material and demonstrated to be sensitive to the amine-based vaginal fluid.
- ANB dye at a concentration of 50-5000 micrograms was placed on the strip on both ends in three relatively circular dots with a diameter of about 7 mm and allowed to air dry, producing an orange color.
- a strip (1.3 cm ⁇ 8 cm) of the material having the three dots on each end (not shown) was then inserted into the pad with the ends just above the baffle as shown in FIGS. 6A and 6B . The dots on the strip were visible through the baffle but the strip was not visible through the body side liner.
- the pad was then insulted with 200 microliters of menses sample with spiked amines (1.5 mg/ml concentration of mixed amines TMA, 1,5-DAP, 1,4-DAB, and tyramine) placed in the target area of the pad.
- spiked amines 1.5 mg/ml concentration of mixed amines TMA, 1,5-DAP, 1,4-DAB, and tyramine
- the orange color of the dye deposits changed color to a grey/black color after approximately ⁇ 10 minutes, indicating the presence of amines and therefore serving as an alert signal for potential vaginitis.
- the dots of dye changed color sequentially with the dot closest to the target area changing color first and the others following in order.
- Assay devices were prepared from a nitrocellulose porous membrane (HF 12002 from Millipore, Inc.) having a length of approximately 30 centimeters laminated onto a corresponding supporting card (60 mm ⁇ 301 mm from Millipore Corporation part number HF00MC100). Chemichromic detection zones were formed on each of the devices using a stock solution ( ⁇ 8.0 milligrams per milliliter) of alpha-naphtholbenzein (Sigma-Aldrich Chemical Company) in a methanol/water mixture (4/6 ratio). One (1) microliter of this stock solution was then spotted onto the assay devices to form the circular indicator zone, and the devices were then dried for 30 minutes at room temperature (25° C.). A cotton swab dipped normal vaginal sample was applied onto circular indicator zone to produce a color change from orange to grey/black color.
- Assay devices as described above in Example 8 were used with a vaginal sample with additional “spiked” amines (1.5 mg/ml concentration of mixed amines TMA, 1,5-DAP, 1,4-DAB, and tyramine) and a cotton swab dipped in this solution was placed onto the circular indicator zone to produce a color change.
- the orange color of the indicator zone changed color to a grey/black color after 1-2 minutes, indicating the presence of amines and therefore serving as an alert signal for potential vaginitis.
- Assay devices as described above in Example 8 were used for menstrual samples and cotton swabs dipped in the samples were placed onto the circular indicator zones to produce a color change.
- Assay devices as described above in Example 8 were used for menstrual samples spiked with amines (1.5 mg/ml concentration of mixed amines TMA, 1,5-DAP, 1,4-DAB, and tyramine) and a dipped cotton swab was placed onto the circular indicator zones to produce a color change.
- the orange color of the indicator zone changed color to a grey/black color after 1-2 minutes, indicating the presence of amines and therefore serving as an alert signal for potential vaginitis.
- This experiment demonstrates the potential application for the visual indicator to detect amines from the center of the pad and act as visual alert to the user.
Abstract
Description
wherein R, R′, and R″ are independently selected from substituted and unsubstituted aryl groups, such as phenyl, naphthyl, anthracenyl, etc. The aryl groups may, for example, be substituted with functional groups, such as amino, hydroxyl, carbonyl, carboxyl, sulfonic, alkyl, and/or other known functional groups. When contacted with the dye, the amino group of the amine (e.g., ammonia, diamines, and/or tertiary amines) reacts with the central carbon atom of the dye. The addition of the amino group causes the dye to undergo a change in color. An example of the resulting structure is set forth below:
Another aspect of the disclosure is method of visualizing bacterial vaginosis that includes the following steps:
Claims (6)
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US13/975,545 US9279140B2 (en) | 2009-02-06 | 2013-08-26 | Personal care products with visual indicator of vaginitis |
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US12/367,286 US8518374B2 (en) | 2004-10-08 | 2009-02-06 | Personal care products with visual indicator of vaginitis |
US13/975,545 US9279140B2 (en) | 2009-02-06 | 2013-08-26 | Personal care products with visual indicator of vaginitis |
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US12/367,286 Continuation-In-Part US8518374B2 (en) | 2004-10-08 | 2009-02-06 | Personal care products with visual indicator of vaginitis |
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Cited By (1)
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US20230054322A1 (en) * | 2021-08-23 | 2023-02-23 | Leslie P. Taylor | Urine indication pad with inbuilt diagnostics for training and indication of potential disease |
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US10448861B2 (en) * | 2013-09-06 | 2019-10-22 | Covidien Lp | System and method for light based lung visualization |
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