US8926902B2 - Aliquoting apparatus for biological material containers - Google Patents
Aliquoting apparatus for biological material containers Download PDFInfo
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- US8926902B2 US8926902B2 US13/256,880 US201013256880A US8926902B2 US 8926902 B2 US8926902 B2 US 8926902B2 US 201013256880 A US201013256880 A US 201013256880A US 8926902 B2 US8926902 B2 US 8926902B2
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- test tubes
- test tube
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- biological material
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
- G01N2035/00861—Identification of carriers, materials or components in automatic analysers printing and sticking of identifiers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/046—General conveyor features
- G01N2035/0467—Switching points ("aiguillages")
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1032—Dilution or aliquotting
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Definitions
- the present invention concerns an apparatus for the withdrawal and distribution of portions of biological materials from a parent test tube transported by an automatic plant for transporting child test tubes, marking and unloading the same from the automatic transport plant towards further processing modules.
- An automatic working chain means a set of devices for processing biological materials, comprising a conveyor belt suitable for presenting the biological material containers to said devices, managing the processing and storing the life cycle thereof.
- Possible hold-ups may be caused because various types of tests generally need to be carried out on the same specimen contained in a single test tube.
- the analyzers suitable for carrying out the required tests on the specimen are not always all connected to the automation chain, but in some cases may be located in different areas of the same laboratory, and sometimes even in different laboratories.
- the specimen may be aliquoted, which consists in portioning the same, from the original test tube, named parent, into several test tubes, named children, thus containing portions of the original biological material specimen.
- the tests to be carried out on the specimen may be carried out in parallel, thus reducing the waiting times and also obtaining a high number of tests on the same specimen in a short time.
- an automatic apparatus suitable for the withdrawal of portions of biological material from a parent test tube, mobile in a conveyor of a test tube transport plant by means of transport devices of single test tubes, to be loaded in one or more child test tubes countermarked beforehand with suitable identification means and to be sent to different biological material analysis instruments interfaced to said transport plant, characterized in that it includes a work bench which provides a first lane for stocking and filling of transport devices with empty child test tubes, a second lane for stocking parent test tubes, said lanes being selectively joined in such a way to consent the sending of single parent test tubes with a predefined number of child test tubes subsequently assigned to be filled of biological material drawn from the parent test tube in a work point, and a return third lane of parent test tubes and child test tubes filled with portions of biological material drawn from parent test tubes, said lanes joining to a conveyor suitable for the transport of test tubes to and from subsequent processing modules, a recruitment device of empty child test tubes, marking and loading devices of empty child test tubes into empty transport devices
- the conveyor comprising the interface area serves the function of presenting the parent test tubes to be aliquoted, transport devices to be loaded with child test tubes and conveying, at the end of the working cycle, the aliquoted test tubes and children test tubes toward further processing modules.
- the marking and loading device of children test tubes ensures a suitable supply of children test tubes, if required during the process.
- the device suitable for withdrawing and distributing biological material from parent test tubes to previously marked children test tubes could be a mechanical arm provided with disposable needle or pipette suitable for drawing a predetermined amount of the biological material contained in the parent test tube and for distributing said material into the children test tube(s) so that such a material may be distributed in previous established equal or different amounts.
- Said device may be integrated with a further device adapted to supply the disposable pipettes.
- the device object of the invention must be capable of coordinating the devices it consists of and running operations in parallel so as to optimize the working cycle.
- a control unit is included, which may be a software application residing on a computer and suitable for receiving information and sending commands to the operating devices.
- FIG. 1 is a perspective view of the aliquoting apparatus
- FIG. 2 is a top plan view of the configuration in FIG. 1 in which the withdrawal and distribution device is shown with a dashed areas for simplicity;
- FIG. 3 is a perspective view of the marking and loading device
- FIG. 4 is a front view of the marking and loading device with some covers and the hopper being removed;
- FIG. 5 is a top plan view of the configuration in FIG. 3 ;
- FIG. 6 is a perspective top view of the test tube revolving device
- FIG. 7 is a perspective bottom view of the configuration in FIG. 6 ;
- FIG. 8 is a perspective view of the test tube marking device
- FIG. 9 is a perspective left side view of the test tube handling device
- FIG. 10 is a perspective right side view of the configuration in FIG. 9 ;
- FIG. 11 is a perspective view of the withdrawal and distribution device
- FIG. 12 is a perspective view of the pipette recruitment device
- FIG. 13 is a perspective bottom view of the pipette container
- FIG. 14 is a perspective view of the pipette raising device.
- FIG. 1 shows an aliquoting or portioning apparatus of biological material from parent test tubes 1 into children test tubes 2 according to the present invention, comprising a marking and loading device 3 of children test tubes 2 and a withdrawal and distribution device 4 of biological material.
- Said devices 3 and 4 interface with a work area or bench 5 connected to a conveyor 6 of a transport plant of test tubes to and from processing and testing modules.
- a conveyor 6 consists of a conveyor belt 7 ( FIGS. 1 and 2 ) organized in lanes and suitable for conveying the test tubes to the interface points with processing modules.
- the conveyor 6 uses test tube transport devices or carriers 8 , suitable for containing the test tubes in a vertical, firm position and further stopping and diverting devices.
- the work area 5 ( FIG. 2 ) comprises a lane 9 adapted to receive empty transport devices 8 from the conveyor 6 , which are queued in said lane 9 waiting for being loaded with children test tubes 2 by the marking and loading apparatus 3 , a lane 10 suitable for presenting conveying devices 8 containing parent test tubes 1 close to the work point 11 of the biological material withdrawal and distribution apparatus 4 , a return lane 12 of parent test tubes 1 and children test tubes 2 filled with aliquots or portions of biological material contained in the parent test tube.
- the conveyor 6 has a main lane 13 ( FIG. 2 ), a diversion 14 adapted to convey empty transport devices 8 into a secondary lane 130 and thus into the lane 9 , a diversion 15 after diversion 14 suitable for conveying transport devices 8 containing parent test tubes 1 of the lane 10 .
- control unit 100 consisting of a software program installed on a personal computer communicating with a code residing on one or more electronic boards suitable for the handling of the involved devices.
- the identity of a parent test tube 1 is communicated by the control unit 100 to the marking and loading apparatus 3 , starting the preparation of child test tubes and ensuring the univocal association with the parent test tube from which the biological material aliquots are extracted.
- the child test tubes may also be marked without providing for any association with the original parent test tube; this depends on the test laboratory request only.
- the information to be included in the children test tube marking may be thus configured, according to the laboratory, in the software which manages the marking during installation of the apparatus in the laboratory.
- the parent test tube is parked in a stop point 16 ; when the children test tubes are appropriately marked, positioned in the lane 9 and queued in a stop point 106 , the parent test tube 1 is released from the stop point 16 to reach the work point 11 , followed by the children test tubes, which are released and queued after the parent behind the work point 11 , passing from lane 9 to lane 10 through the diversion 17 .
- the actual presence of the expected number of children test tubes 2 queued after the parent test tube 1 in the work point 11 is controlled by presence sensors 18 appropriately positioned on lane 10 .
- the number of children test tube to be prepared depends on the type of processing required on the biological material contained in the parent test tube 1 .
- the marking and loading apparatus 3 ( FIG. 3 ) comprises a test tube recruitment device 19 , adapted to present children test tubes 2 to a marking device 20 ; at the end of this operation, the appropriately countermarked children test tubes 2 are positioned in transport devices 8 by a test tube handling device 21 .
- the marked children test tubes 2 positioned in the transport devices 8 are then queued, as previously explained, to the parent test tube 1 in the work point 11 .
- Said work point 11 is the work area of the withdrawal and distribution apparatus 4 ( FIG. 11 ), which comprises a recruitment device 22 of pipettes 23 , having the function of presenting a pipette 23 in an appropriate position at each new work cycle.
- Said pipette 23 ( FIG. 1 ) is a tubular body, equivalent to a pipe, which is adapted to aspirate the biological material contained in the parent test tubes.
- the pipette 23 recruited by the recruitment device 22 , is then engaged and automatically mounted and interlocked on a biological material distribution device 24 , as will be explained below.
- the reason why the pipette for drawing biological material from the parent test tube 1 is changed at each cycle is to avoid risks of contamination between biological materials belonging to different test tubes.
- a parent test tube 1 to be aliquoted contained in a specific transport device is present on the main line 13 of the conveyor 6 ,
- the conveyor 6 diverts such a test tube to lane 10 through diversion 15 to allow the test tube to reach the work area 5 ,
- the parent test tube 1 is stopped by a stop device in waiting point 16 ,
- control unit 100 controls the marking and loading apparatus 3 for preparing a given number of children test tubes (in the example, the children test tubes are 4),
- the marking and loading device 3 thus prepares the required number of children test tubes, marking them and positioning them in the transport devices 8 available and queued in lane 9 ,
- the children test tubes 2 queued in lane 9 are released through diversion 17 to be queued after the parent test tube in lane 10 ,
- a new pipette 23 is recruited by the pipette recruitment device 22 ad positioned in point 64 in which it must be engaged by the distribution device 24 to start the biological material withdrawal operation,
- the distribution device 24 which withdraws the biological material from the parent test tube 1 at the top of the list
- the presence sensors 18 check that the number of children test tubes 2 queued after the parent test tube 1 is the expected one
- the biological material taken by the distribution device 24 with the pipette 23 is distributed in the queued children test tubes,
- the parent 1 and children test tubes 2 are released onto return lane 12 to go back to the main line 13 of the conveyor 6 and may be transported to subsequent processing or analysis modules.
- the test tube recruitment device 19 ( FIG. 4 ) consists of fixed combs 25 and mobile combs 26 .
- the mobile combs 26 move (as shown by the arrows in FIG. 4 ) on fixed combs 25 engaging the test tubes, contained in a hopper 101 ( FIGS. 3 and 5 ), and moving them upwards.
- the mobile combs 26 are moved by an electric motor 27 , which, by means of a transmission system 28 , moves a mobile arm 29 , generating the travel of the mobile combs 26 on the fixed combs 25 ( FIGS. 3 , 4 and 5 ).
- a test tube engaged by such a mechanism reaches the fixed test tube 30 ( FIG. 4 ) positioned in the highest position, slides on an inclined tray 31 falling onto a test tube revolving device 32 ( FIG. 6 ).
- Said tray may accommodate up to 8 test tubes; a presence sensor 33 ( FIG. 4 ) on the cover 34 of the tray 31 has the task of checking the actual presence of the eighth test tube on the tray and possibly stop the operation of the test tube recruitment device 18 to disposal of the 8 test tubes.
- a pneumatically operated test tube timer 35 is over the tray 31 ( FIGS. 3 and 4 ) for checking that the test tubes fall on the revolving device 32 one at a time.
- Said test tube revolution device 32 ( FIG. 6 ) comprises a revolving dish 36 , which includes a lodging 37 consisting of four cylindrical retractable pegs 38 (two of which are not shown in FIG. 6 because they are hidden by the body of the child test tube 2 ) and a fixed cylinder pin 39 in which the test tube falling from the tray 31 is engaged.
- a cylinder 103 ( FIG. 6 ) works as sensor, detecting the position of the test tube on the revolving dish 36 : when the test tube is in the lodging 37 said cylinder 103 is actuated and a piston 102 consequently exits.
- the piston does not enter, it means that the closed end of the test tube is facing the side of the sensor, thus preventing the entrance of the piston therein.
- test tube may be released by the dish 36 ; in the first case, instead, the dish turns by one-hundred-eighty degrees to take the test tube to the desired position.
- the two pneumatic cylinders 41 retract the cylindrical pegs 38 , allowing the release of the test tube into a lodging 104 comprising two rollers 40 ( FIGS. 4 and 8 , in FIG. 8 the second roller 40 is not visible because it is hidden by the body of the test tube 2 positioned in the lodging 104 ).
- the dish 36 ( FIGS. 6 and 7 ), included in a lodging 42 , is inclined with respect to the horizontal to allow the test tube, when released from the cylindrical retractable pegs 38 to roll inside the lodging 104 .
- a cylinder 43 generates the rotation of the plate 36 .
- the linear movement generated by said cylinder 43 is transformed by virtue of a transmission system comprising a rack 44 which by engaging a gear 45 moves a shaft 46 , which generates the rotation of the plate 36 in the lodging 42 , when required.
- the test tube marking device 20 ( FIG. 8 ) comprises a label application device 48 adapted to ensure the adhesion of said adhesive labels onto the side walls of the child test tube 2 positioned in the housing 104 . These adhesive labels are printed by a printer 47 .
- a sensor 500 (positioned in the lodging 104 under the test tube and not visible in FIG. 8 ) confirms the presence of the child test tube 2 , operating the label printer 47 which produces a label containing useful information for identifying the child test tube 2 during the subsequent steps of processing on the conveyor 6 and, if required, associates the identity to the parent test tube.
- Said label, exiting from the printer 47 is engaged between the rollers 40 and, being adhesive on one side, is glued onto the wall of the test tube.
- the label application device 48 has the function of making sure that the label sticks to the side wall of the test tube. It comprises an active roller 49 , the rotation of which generates the rotation of the two rollers 40 , actuated by an electric motor 50 the movement of which is transmitted to the roller 49 by a transmission system 51 .
- rollers may be present in a loading 105 in order to ensure a better revolution of the test tube while the label is being glued.
- the revolution of the rollers is sufficiently long to ensure the adhesion of the label onto the side wall of the test tube.
- the correctly marked child test tube 2 is ready to be loaded into a transport device 8 in lane 9 positioned in a release point 63 ( FIG. 2 ) by the test tube handling device 21 .
- Said test tube handling device 21 ( FIGS. 9 and 10 ) consist of a mechanical arm 56 comprising a gripper 57 capable of gripping the test tube, as shown in the FIG. 9 , and turning on the pins 62 , reaches the release point 63 following the direction of revolution shown by the arrow in FIG. 10 .
- the revolutionary movement of the mechanical arm is obtained by transforming the linear movement of a cylinder 58 by means of a rack 59 contained in a guide 60 on which a circular gear 61 turns.
- the gripper 57 after having reached the release point 63 opens pneumatically and releases the test tube, inserting it in an empty transport device 8 idling in the release point 63 .
- a child test tube ready in its transport device 8 is released from the release point 63 and queued in the stop point 106 ; the described process is repeated and when all the children test tubes 2 are correctly positioned in the corresponding transport devices 8 queued in stop point 106 , are conveyed from lane 9 to lane 10 and queue after the parent test tube positioned in work point 11 ( FIG. 2 ).
- the biological material withdraw and distribution device 4 ( FIG. 11 ) has the task, after having acquired a new pipette 23 from the spare pipette position 64 , to draw a specimen of biological material from the parent test tube 1 at the top of the queue and distribute it into the queuing children test tubes 2 .
- a pipette 23 is prepared in the spare pipette position 64 by means of the pipette recruitment device 22 ( FIG. 12 ), comprising a pipette positioning device 65 and a pipette raising device 66 .
- the pipettes are recruited by a container 150 ( FIG. 13 ) which, for a greater process efficiency, must be loaded with the pipettes positioned in a horizontal direction; it consists of a lower base 67 removable by sliding along guides 68 and comprising a coupling 69 suitable to be engaged by a sliding hook 70 accommodated in a guide 71 positioned on the side wall of the container 150 .
- the pipettes are separately loaded into the container 150 ; subsequently, the container is fitted on the recruitment device 22 ; when correctly positioned in its seat, a support 73 couples with the hook 70 causing the lifting and consequent uncoupling from the coupling 69 , which is immediately coupled by a second hook 74 (not shown in FIG. 12 ) mounted on a slides 75 .
- Said slider 75 by sliding on a cylinder 76 , removes the lower base 67 allowing to open the lower part of the container 150 .
- the vertical movement of the inclined surface 170 and of the comb 171 is generated by a piston 190 .
- the pipettes roll until they reach two guides 173 positioned at reciprocal distance equal to the width of the lower part, the thinnest, of the pipette (enlargement in FIG. 1 ). Said distance allows the pipette to “straighten up” when its reaches it remaining suspended on the edges of the two guides resting on the head which is wider than the body.
- a pushing system 180 consisting of for example a solenoid valve adapted to generate a jet of air in the direction of the pipette 23 positioned on the two guides 173 , generates the movement of said pipette in the direction of a chamber 181 present inside the test tube lifting device 66 , as shown in FIG. 14 .
- the pipettes 23 are pushed upwards, to reach the spare pipette position 64 ( FIG. 12 ) by a pusher 183 moved by means of a piston 182 .
- a mechanical arm 184 suitable for handling the pipette is positioned in a reject tube 185 ( FIG. 1 ), where the pipette inserted inside said tube, is disengaged by the mechanical arm 184 , falling in a pipette reject container 186 .
- the mechanical arm is positioned in the spare pipette position 64 and may engage a new waiting pipette.
Abstract
Description
Claims (3)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI2009A000398A IT1393352B1 (en) | 2009-03-16 | 2009-03-16 | EQUIPMENT FOR THE MAKING OF CONTAINERS OF BIOLOGICAL MATERIAL. |
ITMI2009A000398 | 2009-03-16 | ||
ITMI2009A0398 | 2009-03-16 | ||
PCT/EP2010/053228 WO2010105992A1 (en) | 2009-03-16 | 2010-03-12 | Aliquoting apparatus for biological material containers |
Publications (2)
Publication Number | Publication Date |
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US20120058010A1 US20120058010A1 (en) | 2012-03-08 |
US8926902B2 true US8926902B2 (en) | 2015-01-06 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US13/256,880 Active 2031-07-10 US8926902B2 (en) | 2009-03-16 | 2010-03-12 | Aliquoting apparatus for biological material containers |
Country Status (6)
Country | Link |
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US (1) | US8926902B2 (en) |
EP (1) | EP2409159B1 (en) |
CN (1) | CN102282470B (en) |
ES (1) | ES2735532T3 (en) |
IT (1) | IT1393352B1 (en) |
WO (1) | WO2010105992A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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US20140346009A1 (en) * | 2011-11-16 | 2014-11-27 | Inpeco Holding Ltd. | Process station of devices for conveying biological product containers |
US11181541B2 (en) | 2016-02-17 | 2021-11-23 | Becton Dickinson And Company | Automated sample preparation system for diagnostic testing of same |
US11199560B2 (en) | 2016-04-22 | 2021-12-14 | Becton Dickinson And Company | Automated diagnostic analyzer and method for its operation |
US11353472B2 (en) | 2016-04-22 | 2022-06-07 | Becton Dickinson And Company | Automated sample diagnostic analyzer and method for its operation |
Families Citing this family (12)
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ITMI20080101A1 (en) * | 2008-01-24 | 2009-07-25 | Dachi S R L | "LOADING SYSTEM IN A TRANSPORTATION SYSTEM OF CONTAINERS OF BIOLOGICAL MATERIAL" |
BR112014011035A2 (en) * | 2011-11-07 | 2017-06-13 | Beckman Coulter, Inc. | aliquot system and workflow |
ITMI20120975A1 (en) * | 2012-06-05 | 2013-12-06 | Inpeco Ip Ltd | INTERFACE SYSTEM BETWEEN A LABORATORY AUTOMATION PLANT AND A PLATFORM FOR THE HANDLING OF CONSUMABLES AND LIQUIDS IN MOLECULAR BIOLOGY. |
ITMI20130181A1 (en) * | 2013-02-08 | 2014-08-09 | Inpeco Holding Ltd | TRANSPORT UNIT OF BIOLOGICAL SAMPLES CONTAINERS IN LABORATORY AUTOMATION EQUIPMENT WITH PERIPHERAL UNITS WITH AT LEAST ONE RAMP TRAFFICKING. |
CN103217541A (en) * | 2013-04-23 | 2013-07-24 | 上海裕隆生物科技有限公司 | Full-automatic pipe-type chemiluminescent analyzer |
JP6306340B2 (en) * | 2013-12-20 | 2018-04-04 | 株式会社日立ハイテクノロジーズ | Sample transport device |
US10126318B2 (en) * | 2014-02-19 | 2018-11-13 | Siemens Healthcare Diagnostics Inc. | Mother daughter tube carrier for aliquoters |
US10024875B2 (en) | 2014-03-17 | 2018-07-17 | Inpeco Holding Ltd. | Apparatus for moving and testing biological samples |
FR3043782B1 (en) * | 2015-11-13 | 2017-12-08 | Horiba Abx Sas | STIRRING AND SAMPLING DEVICE FOR SAMPLE BIOLOGICAL LIQUIDS SUITABLE FOR SORTING |
CN107662798A (en) * | 2016-07-27 | 2018-02-06 | 陈贤儒 | Automatically integrating type checking system |
CN111689155A (en) * | 2019-03-12 | 2020-09-22 | 陈贤儒 | Automatic test tube conveying system |
TWI703074B (en) * | 2019-09-09 | 2020-09-01 | 科誠股份有限公司 | Test tube preparing device and preparing method thereof |
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- 2010-03-12 CN CN201080012456XA patent/CN102282470B/en active Active
- 2010-03-12 EP EP10707933.7A patent/EP2409159B1/en active Active
- 2010-03-12 ES ES10707933T patent/ES2735532T3/en active Active
- 2010-03-12 WO PCT/EP2010/053228 patent/WO2010105992A1/en active Application Filing
- 2010-03-12 US US13/256,880 patent/US8926902B2/en active Active
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EP0243915A2 (en) | 1986-04-30 | 1987-11-04 | Teruaki Itoh | Apparatus for distributing liquid samples among test tubes and for dividing the test tubes into groups |
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US20140346009A1 (en) * | 2011-11-16 | 2014-11-27 | Inpeco Holding Ltd. | Process station of devices for conveying biological product containers |
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US11754582B2 (en) | 2016-04-22 | 2023-09-12 | Becton Dickinson And Company | Automated diagnostic analyzer and method for its operation |
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WO2010105992A1 (en) | 2010-09-23 |
CN102282470B (en) | 2013-11-27 |
EP2409159B1 (en) | 2019-05-08 |
CN102282470A (en) | 2011-12-14 |
IT1393352B1 (en) | 2012-04-20 |
ES2735532T3 (en) | 2019-12-19 |
EP2409159A1 (en) | 2012-01-25 |
US20120058010A1 (en) | 2012-03-08 |
ITMI20090398A1 (en) | 2010-09-17 |
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