US8016817B2 - Device for controlling exposure of reservoir contents to surroundings - Google Patents
Device for controlling exposure of reservoir contents to surroundings Download PDFInfo
- Publication number
- US8016817B2 US8016817B2 US12/348,609 US34860909A US8016817B2 US 8016817 B2 US8016817 B2 US 8016817B2 US 34860909 A US34860909 A US 34860909A US 8016817 B2 US8016817 B2 US 8016817B2
- Authority
- US
- United States
- Prior art keywords
- reservoir
- cap
- release
- molecules
- reservoirs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related, expires
Links
- 239000000463 material Substances 0.000 claims abstract description 128
- 239000000758 substrate Substances 0.000 claims abstract description 73
- 230000008859 change Effects 0.000 claims abstract description 30
- 238000010438 heat treatment Methods 0.000 claims abstract description 23
- 229910052751 metal Inorganic materials 0.000 claims description 11
- 239000002184 metal Substances 0.000 claims description 11
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 238000000034 method Methods 0.000 description 77
- 235000012431 wafers Nutrition 0.000 description 70
- 229920002120 photoresistant polymer Polymers 0.000 description 41
- 238000012384 transportation and delivery Methods 0.000 description 39
- 238000004519 manufacturing process Methods 0.000 description 36
- -1 poly(ethylene glycol) Polymers 0.000 description 36
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 32
- 239000003814 drug Substances 0.000 description 25
- 229940079593 drug Drugs 0.000 description 24
- 229920000642 polymer Polymers 0.000 description 23
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 21
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 21
- 239000012528 membrane Substances 0.000 description 21
- 229910052710 silicon Inorganic materials 0.000 description 21
- 239000010703 silicon Substances 0.000 description 21
- 239000000203 mixture Substances 0.000 description 19
- 230000008569 process Effects 0.000 description 19
- HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 description 18
- 238000004528 spin coating Methods 0.000 description 18
- 238000001727 in vivo Methods 0.000 description 17
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 16
- 229910052581 Si3N4 Inorganic materials 0.000 description 16
- 229910052697 platinum Inorganic materials 0.000 description 16
- 230000015556 catabolic process Effects 0.000 description 15
- 238000006731 degradation reaction Methods 0.000 description 15
- 150000004767 nitrides Chemical class 0.000 description 15
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 14
- 238000011049 filling Methods 0.000 description 14
- 239000000126 substance Substances 0.000 description 14
- 239000010409 thin film Substances 0.000 description 14
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 12
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 12
- CSCPPACGZOOCGX-UHFFFAOYSA-N acetone Substances CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 12
- 238000001816 cooling Methods 0.000 description 12
- 238000000151 deposition Methods 0.000 description 12
- 239000007789 gas Substances 0.000 description 12
- 238000005530 etching Methods 0.000 description 11
- 239000010408 film Substances 0.000 description 11
- 238000002347 injection Methods 0.000 description 11
- 239000007924 injection Substances 0.000 description 11
- 230000001419 dependent effect Effects 0.000 description 10
- 238000009792 diffusion process Methods 0.000 description 10
- 238000000338 in vitro Methods 0.000 description 10
- 238000007641 inkjet printing Methods 0.000 description 10
- 239000012071 phase Substances 0.000 description 10
- 230000008021 deposition Effects 0.000 description 9
- FFUAGWLWBBFQJT-UHFFFAOYSA-N hexamethyldisilazane Chemical compound C[Si](C)(C)N[Si](C)(C)C FFUAGWLWBBFQJT-UHFFFAOYSA-N 0.000 description 9
- 230000008018 melting Effects 0.000 description 9
- 238000002844 melting Methods 0.000 description 9
- 238000012545 processing Methods 0.000 description 9
- 239000007787 solid Substances 0.000 description 9
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 description 9
- 239000011810 insulating material Substances 0.000 description 8
- 238000010884 ion-beam technique Methods 0.000 description 8
- 238000000206 photolithography Methods 0.000 description 8
- 239000004065 semiconductor Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 7
- 239000000919 ceramic Substances 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 7
- 239000011521 glass Substances 0.000 description 7
- 230000007246 mechanism Effects 0.000 description 7
- 150000002739 metals Chemical class 0.000 description 7
- 239000001301 oxygen Substances 0.000 description 7
- 229910052760 oxygen Inorganic materials 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 6
- 229920001577 copolymer Polymers 0.000 description 6
- 239000003989 dielectric material Substances 0.000 description 6
- 238000012377 drug delivery Methods 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 230000035699 permeability Effects 0.000 description 6
- 239000000377 silicon dioxide Substances 0.000 description 6
- 235000012239 silicon dioxide Nutrition 0.000 description 6
- 239000000560 biocompatible material Substances 0.000 description 5
- 238000003486 chemical etching Methods 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 5
- 230000007613 environmental effect Effects 0.000 description 5
- 230000001965 increasing effect Effects 0.000 description 5
- 238000004377 microelectronic Methods 0.000 description 5
- 238000000623 plasma-assisted chemical vapour deposition Methods 0.000 description 5
- 230000000541 pulsatile effect Effects 0.000 description 5
- 230000004044 response Effects 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 230000004913 activation Effects 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
- 239000002131 composite material Substances 0.000 description 4
- 239000003792 electrolyte Substances 0.000 description 4
- 238000001704 evaporation Methods 0.000 description 4
- 230000008020 evaporation Effects 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- QPJSUIGXIBEQAC-UHFFFAOYSA-N n-(2,4-dichloro-5-propan-2-yloxyphenyl)acetamide Chemical compound CC(C)OC1=CC(NC(C)=O)=C(Cl)C=C1Cl QPJSUIGXIBEQAC-UHFFFAOYSA-N 0.000 description 4
- 238000001020 plasma etching Methods 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- WGTYBPLFGIVFAS-UHFFFAOYSA-M tetramethylammonium hydroxide Chemical compound [OH-].C[N+](C)(C)C WGTYBPLFGIVFAS-UHFFFAOYSA-M 0.000 description 4
- 241001050985 Disco Species 0.000 description 3
- 241000529895 Stercorarius Species 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 238000007792 addition Methods 0.000 description 3
- 229920002988 biodegradable polymer Polymers 0.000 description 3
- 239000004621 biodegradable polymer Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000036760 body temperature Effects 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000005229 chemical vapour deposition Methods 0.000 description 3
- 230000008602 contraction Effects 0.000 description 3
- 229920006237 degradable polymer Polymers 0.000 description 3
- 238000010894 electron beam technology Methods 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 230000009477 glass transition Effects 0.000 description 3
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 3
- 229910052737 gold Inorganic materials 0.000 description 3
- 239000010931 gold Substances 0.000 description 3
- 239000001307 helium Substances 0.000 description 3
- 229910052734 helium Inorganic materials 0.000 description 3
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 3
- 150000002596 lactones Chemical class 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 238000000059 patterning Methods 0.000 description 3
- 229920000728 polyester Polymers 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 241000252506 Characiformes Species 0.000 description 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 125000002947 alkylene group Chemical group 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 125000003636 chemical group Chemical group 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000004020 conductor Substances 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- BUMGIEFFCMBQDG-UHFFFAOYSA-N dichlorosilicon Chemical compound Cl[Si]Cl BUMGIEFFCMBQDG-UHFFFAOYSA-N 0.000 description 2
- 238000001312 dry etching Methods 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 230000003628 erosive effect Effects 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 230000033444 hydroxylation Effects 0.000 description 2
- 238000005805 hydroxylation reaction Methods 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000002648 laminated material Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229910052744 lithium Inorganic materials 0.000 description 2
- 238000004518 low pressure chemical vapour deposition Methods 0.000 description 2
- 230000000873 masking effect Effects 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 229910000069 nitrogen hydride Inorganic materials 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 229910052814 silicon oxide Inorganic materials 0.000 description 2
- 238000004544 sputter deposition Methods 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 238000012385 systemic delivery Methods 0.000 description 2
- 238000007736 thin film deposition technique Methods 0.000 description 2
- 230000001960 triggered effect Effects 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 1
- 241000282461 Canis lupus Species 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- XPDWGBQVDMORPB-UHFFFAOYSA-N Fluoroform Chemical compound FC(F)F XPDWGBQVDMORPB-UHFFFAOYSA-N 0.000 description 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 1
- 102000004310 Ion Channels Human genes 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 229920002732 Polyanhydride Polymers 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- 229920001710 Polyorthoester Polymers 0.000 description 1
- 229910008045 Si-Si Inorganic materials 0.000 description 1
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 229910006411 Si—Si Inorganic materials 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 229910021417 amorphous silicon Inorganic materials 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 229940035674 anesthetics Drugs 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000002508 contact lithography Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 229940039227 diagnostic agent Drugs 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000005566 electron beam evaporation Methods 0.000 description 1
- 230000003028 elevating effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007071 enzymatic hydrolysis Effects 0.000 description 1
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 150000001261 hydroxy acids Chemical class 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- 239000002955 immunomodulating agent Substances 0.000 description 1
- 229940121354 immunomodulator Drugs 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000008011 inorganic excipient Substances 0.000 description 1
- 239000012212 insulator Substances 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000010338 mechanical breakdown Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 125000005395 methacrylic acid group Chemical class 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000000520 microinjection Methods 0.000 description 1
- 238000005459 micromachining Methods 0.000 description 1
- 238000001053 micromoulding Methods 0.000 description 1
- 238000002324 minimally invasive surgery Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 239000008012 organic excipient Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 239000006179 pH buffering agent Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 229920001308 poly(aminoacid) Polymers 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 1
- 229920001610 polycaprolactone Polymers 0.000 description 1
- 229910021420 polycrystalline silicon Inorganic materials 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 238000007569 slipcasting Methods 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000000807 solvent casting Methods 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- SFZCNBIFKDRMGX-UHFFFAOYSA-N sulfur hexafluoride Chemical compound FS(F)(F)(F)(F)F SFZCNBIFKDRMGX-UHFFFAOYSA-N 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
- B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0097—Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0819—Microarrays; Biochips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Micromachines (AREA)
- Medicinal Preparation (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Secondary Cells (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Abstract
Description
-
- Dichlorosilane (SiH2Cl2)=253 sccm
-
- (“HMDS vapor prime”) in vacuum oven approximately 30 min. at 150° C.
-
- 7 sec. at 500 rpm (coat); 7 sec. at 750 rpm (spread); and
- 30 sec. at 3500 rpm (spin)
-
- 32 sec. at wavelength=320 nm
-
- Develop Time=approximately 40 seconds
-
- Carbon Tetrafluoride (CF4)=15 sccm
-
- 6 sec. at 500 rpm (coat); 6 sec. at 750 rpm (spread); and
- 30 sec. at 4000 rpm (spin)
-
- 40 sec. at wavelength=320 nm
-
- Approximately 200 sec. at wavelength=320 nm
-
- Develop Time=approximately 1 min. 30 sec.
-
- 7 sec. at 500 rpm (coat); 7 sec. at 750 rpm (spread); and
- 30 sec. at 3500 rpm (spin)
-
- 32 sec. at wavelength=320 nm
-
- Develop Time=approximately 55 sec.
19) Allow the solvent in the thermally responsive polymer solution to evaporate, resulting in the formation of a solid polymeric reservoir cap covering the
-
- The drying time and temperature depend on the particular solvent used in the polymer solution (e.g., water takes longer to evaporate than methanol).
20) Use a microinjector or other filling technique to fill the reservoir withrelease system 400 a/420 a (and implied step between 420 b and 440 b) and then seal the large reservoir opening by bonding a backing plate across the large opening side of thesubstrate 440 a/440 b.
21) Dice the wafers with a diesaw (Disco Automatic Dicing Saw Model DAD-2H/6T). - Process yields 21 devices per 4″ wafer with each device measuring 17 mm by 17 mm on a side
Fabrication of the active microchip devices having resistors near the reservoir caps is complete.
- The drying time and temperature depend on the particular solvent used in the polymer solution (e.g., water takes longer to evaporate than methanol).
-
- 6 sec. at 500 rpm (coat); 6 sec. at 750 rpm (spread); and
- 30 sec. at 4000 rpm (spin)
-
- 40 sec. at wavelength=320 nm
-
- Approximately 200 sec. at wavelength=320 nm
-
- Develop Time=approximately 1 min. 30 sec.
-
- Process yields 21 devices per 4″ wafer with each device measuring 17 mm by 17 mm on a side
Fabrication of the active microchip devices having resistors in the reservoirs is complete.
- Process yields 21 devices per 4″ wafer with each device measuring 17 mm by 17 mm on a side
-
- Wafer thickness=approximately 295-310 μm for devices with reservoirs extending completely through the wafer (devices that do not have reservoirs extending all the way through the wafer can be of any desired thickness)
2) Deposit approximately 1600-1900 Å of low stress (10:1, silicon rich) silicon nitride on both sides of the wafers in an SVG/Thermco 7000 Series vertical tube reactor (VTR) 30.
- Wafer thickness=approximately 295-310 μm for devices with reservoirs extending completely through the wafer (devices that do not have reservoirs extending all the way through the wafer can be of any desired thickness)
-
- Dichlorosilane (SiH2Cl2)=253 sccm
-
- Hexamethyldisilazane deposition on both sides of the wafer (“HMDS vapor prime”) in vacuum oven approximately 30 min. at 150° C.
-
- 7 sec. at 500 rpm (coat); 7 sec. at 750 rpm (spread); and
- 30 sec. at 3500 rpm (spin)
-
- 32 sec. at wavelength=320 nm
-
- Develop Time=approximately 40 seconds
-
- Carbon Tetrafluoride (CF4)=15 sccm
-
- 10 sec. in 50:1 water:HF solution (by volume)
9) Seal the reservoir openings on the side of the wafer through which the reservoirs were filled 44.
10) Etch the nitride membranes on the side of the wafer opposite the filling side by using a plasma etcher (Plasmaquest Series II Reactor Model 145) until the cap material or release system is reached (etch parameters may vary depending on the type of cap material or release system under the nitride) 46.
-
- Carbon Tetrafluoride (CF4)=15 sccm
-
- 7 sec. at 500 rpm (coat); 7 sec. at 750 rpm (spread); and
- 30 sec. at 3500 rpm (spin)
-
- Process yields 21 devices per 4″ wafer with each device measuring 17 mm by 17 mm on a side
13) Clean the devices with solvents and O2 plasma (these steps may not be necessary, depending on the type of exposed cap material or release system).
- Process yields 21 devices per 4″ wafer with each device measuring 17 mm by 17 mm on a side
-
- Gas Flows: O2=25 sccm; He=15 sccm
- Power: RF=10 W; ECR=200 W
- Chamber Pressure=20 mtorr; Temperature=25° C.
Fabrication of the passive microchip devices is complete.
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/348,609 US8016817B2 (en) | 1999-08-18 | 2009-01-05 | Device for controlling exposure of reservoir contents to surroundings |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14949399P | 1999-08-18 | 1999-08-18 | |
US09/638,109 US6527762B1 (en) | 1999-08-18 | 2000-08-11 | Thermally-activated microchip chemical delivery devices |
US10/341,305 US6669683B2 (en) | 1999-08-18 | 2003-01-13 | Thermally-activated microchip chemical delivery devices |
US10/747,900 US7473248B2 (en) | 1999-08-18 | 2003-12-29 | Thermally-activated reservoir devices |
US12/348,609 US8016817B2 (en) | 1999-08-18 | 2009-01-05 | Device for controlling exposure of reservoir contents to surroundings |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/747,900 Continuation US7473248B2 (en) | 1999-08-18 | 2003-12-29 | Thermally-activated reservoir devices |
Publications (2)
Publication Number | Publication Date |
---|---|
US20090112188A1 US20090112188A1 (en) | 2009-04-30 |
US8016817B2 true US8016817B2 (en) | 2011-09-13 |
Family
ID=22530537
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/638,109 Expired - Lifetime US6527762B1 (en) | 1999-08-18 | 2000-08-11 | Thermally-activated microchip chemical delivery devices |
US10/341,305 Expired - Lifetime US6669683B2 (en) | 1999-08-18 | 2003-01-13 | Thermally-activated microchip chemical delivery devices |
US10/747,900 Expired - Fee Related US7473248B2 (en) | 1999-08-18 | 2003-12-29 | Thermally-activated reservoir devices |
US12/348,609 Expired - Fee Related US8016817B2 (en) | 1999-08-18 | 2009-01-05 | Device for controlling exposure of reservoir contents to surroundings |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/638,109 Expired - Lifetime US6527762B1 (en) | 1999-08-18 | 2000-08-11 | Thermally-activated microchip chemical delivery devices |
US10/341,305 Expired - Lifetime US6669683B2 (en) | 1999-08-18 | 2003-01-13 | Thermally-activated microchip chemical delivery devices |
US10/747,900 Expired - Fee Related US7473248B2 (en) | 1999-08-18 | 2003-12-29 | Thermally-activated reservoir devices |
Country Status (8)
Country | Link |
---|---|
US (4) | US6527762B1 (en) |
EP (1) | EP1210064B1 (en) |
JP (2) | JP4397558B2 (en) |
AT (1) | ATE290364T1 (en) |
AU (1) | AU6639400A (en) |
CA (1) | CA2381951A1 (en) |
DE (1) | DE60018582T2 (en) |
WO (1) | WO2001012157A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9024394B2 (en) | 2013-05-22 | 2015-05-05 | Transient Electronics, Inc. | Controlled transformation of non-transient electronics |
US10737090B2 (en) | 2017-07-11 | 2020-08-11 | Medtronic, Inc. | External defibrillation electrode conductive electrolyte dispersal pad |
Families Citing this family (220)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6783543B2 (en) * | 2000-06-05 | 2004-08-31 | Scimed Life Systems, Inc. | Intravascular stent with increasing coating retaining capacity |
US7070590B1 (en) | 1996-07-02 | 2006-07-04 | Massachusetts Institute Of Technology | Microchip drug delivery devices |
US7341598B2 (en) | 1999-01-13 | 2008-03-11 | Boston Scientific Scimed, Inc. | Stent with protruding branch portion for bifurcated vessels |
CA2358296A1 (en) * | 1999-01-05 | 2000-07-13 | Anthony P. Adamis | Targeted transscleral controlled release drug delivery to the retina and choroid |
DE60018582T2 (en) * | 1999-08-18 | 2006-01-19 | Microchips, Inc., Bedford | THERMALLY ACTIVATABLE MICROCHIP AS CHARGING DEVICE FOR CHEMICALS |
EP2308522A3 (en) | 1999-11-17 | 2012-02-29 | Boston Scientific Limited | Microfabricated devices for the delivery of molecules into a carrier fluid |
US6982058B2 (en) * | 1999-12-08 | 2006-01-03 | Baxter International, Inc. | Method for fabricating three dimensional structures |
US6808522B2 (en) | 1999-12-10 | 2004-10-26 | Massachusetts Institute Of Technology | Microchip devices for delivery of molecules and methods of fabrication thereof |
ATE499988T1 (en) | 2000-03-02 | 2011-03-15 | Microchips Inc | MICROMECHANICAL DEVICES AND METHODS FOR STORAGE AND SELECTIVE EXPOSURE OF CHEMICALS |
ATE525977T1 (en) * | 2000-06-05 | 2011-10-15 | Boston Scient Ltd | INTRAVASCULAR STENT WITH IMPROVED RETENTION CAPACITY OF A COATING |
AU2001283359A1 (en) * | 2000-08-14 | 2002-02-25 | Pharmacia Corporation | Drug release (delivery system) |
DE60116520T2 (en) * | 2000-10-10 | 2006-08-31 | Microchips, Inc., Bedford | MICROCHIP RESERVOIR DEVICES WITH WIRELESS TRANSMISSION OF ENERGY AND DATA |
FR2817969B1 (en) * | 2000-12-08 | 2003-02-28 | Diagast | DEVICE AND METHOD FOR IMMUNOLOGICAL ANALYSIS |
US20040209190A1 (en) * | 2000-12-22 | 2004-10-21 | Yoshiaki Mori | Pattern forming method and apparatus used for semiconductor device, electric circuit, display module, and light emitting device |
JP4657577B2 (en) * | 2001-01-09 | 2011-03-23 | マイクロチップス・インコーポレーテッド | Flexible microchip device for ocular and other applications |
US6858220B2 (en) | 2001-02-28 | 2005-02-22 | Second Sight Medical Products, Inc. | Implantable microfluidic delivery system using ultra-nanocrystalline diamond coating |
US7232460B2 (en) * | 2001-04-25 | 2007-06-19 | Xillus, Inc. | Nanodevices, microdevices and sensors on in-vivo structures and method for the same |
WO2002096389A1 (en) * | 2001-05-30 | 2002-12-05 | Microchips, Inc. | Conformal coated microchip reservoir devices |
WO2002099457A1 (en) * | 2001-05-31 | 2002-12-12 | Massachusetts Inst Technology | Microchip devices with improved reservoir opening |
EP1399135B1 (en) | 2001-06-28 | 2004-12-29 | Microchips, Inc. | Methods for hermetically sealing microchip reservoir devices |
US6936183B2 (en) * | 2001-10-17 | 2005-08-30 | Applied Materials, Inc. | Etch process for etching microstructures |
US7097775B2 (en) * | 2001-10-26 | 2006-08-29 | Second Sight Medical Products, Inc. | Coated microfluidic delivery system |
WO2003048665A1 (en) | 2001-12-03 | 2003-06-12 | Massachusetts Institute Of Technology | Microscale lyophilization and drying methods for the stabilization of molecules |
US20040073175A1 (en) * | 2002-01-07 | 2004-04-15 | Jacobson James D. | Infusion system |
AU2003217531A1 (en) * | 2002-05-02 | 2003-11-17 | Massachusetts Eye And Ear Infirmary | Ocular drug delivery systems and use thereof |
US6953455B2 (en) * | 2002-07-30 | 2005-10-11 | Hospira, Inc. | Medicine delivery system |
AU2007200736B2 (en) * | 2002-08-16 | 2008-09-18 | Microchips, Inc. | Controlled release device and method |
JP4436258B2 (en) * | 2002-08-16 | 2010-03-24 | マイクロチップス・インコーポレーテッド | Controlled release device and method |
US7497855B2 (en) * | 2002-09-04 | 2009-03-03 | Microchips, Inc. | Method and device for the controlled delivery of parathyroid hormone |
US7534241B2 (en) * | 2002-09-23 | 2009-05-19 | Microchips, Inc. | Micro-reservoir osmotic release systems and microtube array device |
US7599737B2 (en) * | 2002-10-04 | 2009-10-06 | Microchips, Inc. | Medical device for neural stimulation and controlled drug delivery |
AU2003279842A1 (en) * | 2002-10-04 | 2004-05-04 | Microchips, Inc. | Medical device for controlled drug delivery and cardiac monitoring and/or stimulation |
IL152629A (en) * | 2002-11-04 | 2010-12-30 | Innoventions Ltd | Implantable medical device for controlled release of a substance |
WO2004073551A2 (en) * | 2003-02-18 | 2004-09-02 | Massachusetts Eye And Ear Infirmary | Transscleral drug delivery device and related methods |
CA2523432C (en) * | 2003-04-25 | 2014-10-28 | Microchips, Inc. | Solid drug formulation and device for storage and controlled delivery thereof |
US7114312B2 (en) * | 2003-07-17 | 2006-10-03 | Microchips, Inc. | Low temperature methods for hermetically sealing reservoir devices |
WO2005016558A2 (en) | 2003-08-04 | 2005-02-24 | Microchips, Inc. | Methods for accelerated release of material from a reservoir device |
US7169405B2 (en) * | 2003-08-06 | 2007-01-30 | Warsaw Orthopedic, Inc. | Methods and devices for the treatment of intervertebral discs |
KR101330431B1 (en) | 2003-09-11 | 2013-11-20 | 테라노스, 인코포레이티드 | Medical device for analyte monitoring and drug delivery |
US20050107742A1 (en) * | 2003-09-15 | 2005-05-19 | The Regents Of The University Of Michigan | Shatter-resistant microprobes |
EP1694200B1 (en) * | 2003-11-03 | 2010-09-29 | MicroCHIPS, Inc. | Medical device for sensing glucose |
EP1691679B1 (en) * | 2003-11-13 | 2010-08-11 | Medtronic MiniMed, Inc. | Long term analyte sensor array |
US8414489B2 (en) * | 2003-11-13 | 2013-04-09 | Medtronic Minimed, Inc. | Fabrication of multi-sensor arrays |
US7457667B2 (en) | 2004-02-19 | 2008-11-25 | Silverleaf Medical Products, Inc. | Current producing surface for a wound dressing |
US9801527B2 (en) | 2004-04-19 | 2017-10-31 | Gearbox, Llc | Lumen-traveling biological interface device |
US8024036B2 (en) | 2007-03-19 | 2011-09-20 | The Invention Science Fund I, Llc | Lumen-traveling biological interface device and method of use |
US9011329B2 (en) | 2004-04-19 | 2015-04-21 | Searete Llc | Lumenally-active device |
US8337482B2 (en) | 2004-04-19 | 2012-12-25 | The Invention Science Fund I, Llc | System for perfusion management |
US8000784B2 (en) | 2004-04-19 | 2011-08-16 | The Invention Science Fund I, Llc | Lumen-traveling device |
US8092549B2 (en) | 2004-09-24 | 2012-01-10 | The Invention Science Fund I, Llc | Ciliated stent-like-system |
US7850676B2 (en) * | 2004-04-19 | 2010-12-14 | The Invention Science Fund I, Llc | System with a reservoir for perfusion management |
US8353896B2 (en) | 2004-04-19 | 2013-01-15 | The Invention Science Fund I, Llc | Controllable release nasal system |
US7998060B2 (en) | 2004-04-19 | 2011-08-16 | The Invention Science Fund I, Llc | Lumen-traveling delivery device |
US8361013B2 (en) | 2004-04-19 | 2013-01-29 | The Invention Science Fund I, Llc | Telescoping perfusion management system |
JP4709836B2 (en) * | 2004-05-21 | 2011-06-29 | ギブン イメージング リミテッド | Autonomous internal device |
WO2006085908A2 (en) * | 2004-06-01 | 2006-08-17 | Microchips, Inc. | Devices and methods for measuring and enhancing drug or analyte transport to/from medical implant |
WO2005122959A2 (en) | 2004-06-08 | 2005-12-29 | Advanced Stent Technologies, Inc. | Stent with protruding branch portion for bifurcated vessels |
US9267167B2 (en) * | 2004-06-28 | 2016-02-23 | Becton, Dickinson And Company | Dissolvable films and methods including the same |
US20070036835A1 (en) * | 2004-07-19 | 2007-02-15 | Microchips, Inc. | Hermetically Sealed Devices for Controlled Release or Exposure of Reservoir Contents |
US7537590B2 (en) * | 2004-07-30 | 2009-05-26 | Microchips, Inc. | Multi-reservoir device for transdermal drug delivery and sensing |
US7026441B2 (en) * | 2004-08-12 | 2006-04-11 | Intel Corporation | Thermoresponsive sensor comprising a polymer solution |
ATE424928T1 (en) * | 2004-09-01 | 2009-03-15 | Microchips Inc | CONTAINER DEVICES WITH MULTIPLE CLOSURES FOR CONTROLLED DISPENSING OR EXPOSURE OF CONTAINERS CONTENTS |
EP1802258A4 (en) | 2004-09-13 | 2015-09-23 | Chrono Therapeutics Inc | Biosynchronous transdermal drug delivery |
GB2418144A (en) * | 2004-09-17 | 2006-03-22 | Psimedica Ltd | Medical device for delivery of beneficial substance |
CA2583911A1 (en) * | 2004-10-28 | 2006-05-11 | Microchips, Inc. | Orthopedic and dental implant devices providing controlled drug delivery |
CN101080359A (en) | 2004-11-04 | 2007-11-28 | 微芯片公司 | Compression and cold weld sealing methods and devices |
US7413846B2 (en) * | 2004-11-15 | 2008-08-19 | Microchips, Inc. | Fabrication methods and structures for micro-reservoir devices |
US20080009801A1 (en) * | 2004-12-02 | 2008-01-10 | Nickel Janice H | Method for dispensing material into a drug delivery device |
CA2591092A1 (en) * | 2004-12-17 | 2006-06-22 | Alza Corporation | Temperature modulation of transdermal drug delivery |
DE102004061732B4 (en) * | 2004-12-17 | 2015-05-21 | Technische Universität Dresden | Controllable device consisting of several hydrogel-based individual storage cells |
US7827983B2 (en) * | 2004-12-20 | 2010-11-09 | Hewlett-Packard Development Company, L.P. | Method for making a pharmaceutically active ingredient abuse-prevention device |
CA2595457A1 (en) * | 2005-01-25 | 2006-08-03 | Microchips, Inc. | Control of drug release by transient modification of local microenvironments |
US7888125B2 (en) * | 2005-05-09 | 2011-02-15 | Theranos, Inc. | Calibration of fluidic devices |
US8309057B2 (en) * | 2005-06-10 | 2012-11-13 | The Invention Science Fund I, Llc | Methods for elevating neurotrophic agents |
WO2007001624A2 (en) * | 2005-06-28 | 2007-01-04 | Microchips, Inc. | Medical and dental implant devices for controlled drug delivery |
JP2009511153A (en) * | 2005-10-11 | 2009-03-19 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Individually operated sensors for embeddable sensors |
WO2007047556A2 (en) * | 2005-10-14 | 2007-04-26 | Microchips, Inc. | Passive wear-indicating sensor for implantable prosthetic device |
US8083710B2 (en) | 2006-03-09 | 2011-12-27 | The Invention Science Fund I, Llc | Acoustically controlled substance delivery device |
US9067047B2 (en) * | 2005-11-09 | 2015-06-30 | The Invention Science Fund I, Llc | Injectable controlled release fluid delivery system |
US8936590B2 (en) | 2005-11-09 | 2015-01-20 | The Invention Science Fund I, Llc | Acoustically controlled reaction device |
US20070106271A1 (en) | 2005-11-09 | 2007-05-10 | Searete Llc, A Limited Liability Corporation | Remote control of substance delivery system |
US8273071B2 (en) | 2006-01-18 | 2012-09-25 | The Invention Science Fund I, Llc | Remote controller for substance delivery system |
US8992511B2 (en) | 2005-11-09 | 2015-03-31 | The Invention Science Fund I, Llc | Acoustically controlled substance delivery device |
US9028467B2 (en) | 2005-11-09 | 2015-05-12 | The Invention Science Fund I, Llc | Osmotic pump with remotely controlled osmotic pressure generation |
US8585684B2 (en) | 2005-11-09 | 2013-11-19 | The Invention Science Fund I, Llc | Reaction device controlled by magnetic control signal |
US7540881B2 (en) | 2005-12-22 | 2009-06-02 | Boston Scientific Scimed, Inc. | Bifurcation stent pattern |
ES2643140T3 (en) * | 2005-12-22 | 2017-11-21 | Oakwood Laboratories L.L.C. | Sublimable slow release delivery system and procedure for carrying it out |
SE531121C2 (en) * | 2005-12-30 | 2008-12-23 | Nanospace Ab | One-off valve |
US20080140057A1 (en) * | 2006-03-09 | 2008-06-12 | Searete Llc, A Limited Liability Corporation Of State Of The Delaware | Injectable controlled release fluid delivery system |
EP1998829B1 (en) * | 2006-03-14 | 2011-02-09 | University Of Southern California | Mems device for delivery of therapeutic agents |
US8323570B2 (en) * | 2006-03-21 | 2012-12-04 | Koninklijke Philips Electronics N.V. | Microelectronic sensor device with sensor array |
US8741230B2 (en) | 2006-03-24 | 2014-06-03 | Theranos, Inc. | Systems and methods of sample processing and fluid control in a fluidic system |
US11287421B2 (en) | 2006-03-24 | 2022-03-29 | Labrador Diagnostics Llc | Systems and methods of sample processing and fluid control in a fluidic system |
WO2007120640A2 (en) * | 2006-04-11 | 2007-10-25 | University Of South Florida | Thermally induced single-use valves and method of use |
US20080058785A1 (en) | 2006-04-12 | 2008-03-06 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Autofluorescent imaging and target ablation |
US20120035437A1 (en) | 2006-04-12 | 2012-02-09 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Navigation of a lumen traveling device toward a target |
US7771414B2 (en) * | 2006-04-24 | 2010-08-10 | Warsaw Orthopedic, Inc. | Controlled release devices for therapeutic treatments of spinal discs |
US7879027B2 (en) * | 2006-04-24 | 2011-02-01 | Warsaw Orthopedic, Inc. | Controlled release devices for fusion of osteal structures |
US8642059B2 (en) | 2006-04-24 | 2014-02-04 | Warsaw Orthopedic, Inc. | Controlled release systems and methods for intervertebral discs |
US8642060B2 (en) * | 2006-04-24 | 2014-02-04 | Warsaw Orthopedic, Inc. | Controlled release systems and methods for osteal growth |
US7846158B2 (en) * | 2006-05-05 | 2010-12-07 | Covidien Ag | Apparatus and method for electrode thermosurgery |
US8007999B2 (en) | 2006-05-10 | 2011-08-30 | Theranos, Inc. | Real-time detection of influenza virus |
EP2029216A1 (en) * | 2006-06-02 | 2009-03-04 | Koninklijke Philips Electronics N.V. | Device for the controlled release of a substance |
US7803148B2 (en) * | 2006-06-09 | 2010-09-28 | Neurosystec Corporation | Flow-induced delivery from a drug mass |
EP1867990A1 (en) * | 2006-06-14 | 2007-12-19 | Koninklijke Philips Electronics N.V. | Sensitive assay through amplification of a label signal |
WO2008008845A2 (en) * | 2006-07-11 | 2008-01-17 | Microchips, Inc. | Multi-reservoir pump device for dialysis, biosensing, or delivery of substances |
JP2009544393A (en) * | 2006-07-27 | 2009-12-17 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Drug delivery system with heat-switchable membrane |
US20080033260A1 (en) * | 2006-08-03 | 2008-02-07 | Microchips, Inc. | Cardiac Biosensor Devices and Methods |
US20130226267A9 (en) * | 2006-08-21 | 2013-08-29 | Marom Bikson | Method to reduce heating at implantable medical devices including neuroprosthetic devices |
WO2008029372A2 (en) * | 2006-09-08 | 2008-03-13 | Koninklijke Philips Electronics N.V. | Device for the controlled release of a predefined quantity of a substance |
US20080060995A1 (en) * | 2006-09-12 | 2008-03-13 | Sean Zhang | Semi-Permeable Membrane |
US7951191B2 (en) | 2006-10-10 | 2011-05-31 | Boston Scientific Scimed, Inc. | Bifurcated stent with entire circumferential petal |
US20080113391A1 (en) * | 2006-11-14 | 2008-05-15 | Ian Gibbons | Detection and quantification of analytes in bodily fluids |
US7842082B2 (en) | 2006-11-16 | 2010-11-30 | Boston Scientific Scimed, Inc. | Bifurcated stent |
EP2157907B1 (en) | 2007-06-07 | 2013-03-27 | MicroCHIPS, Inc. | Electrochemical biosensors and arrays |
DE102007032688A1 (en) * | 2007-07-13 | 2009-01-22 | Biotronik Vi Patent Ag | Implant and system of an implant and an excitation device |
US8158430B1 (en) | 2007-08-06 | 2012-04-17 | Theranos, Inc. | Systems and methods of fluidic sample processing |
US7959669B2 (en) | 2007-09-12 | 2011-06-14 | Boston Scientific Scimed, Inc. | Bifurcated stent with open ended side branch support |
US20090076591A1 (en) * | 2007-09-19 | 2009-03-19 | Boston Scientific Scimed, Inc. | Stent Design Allowing Extended Release of Drug and/or Enhanced Adhesion of Polymer to OD Surface |
EP2052700A1 (en) | 2007-09-26 | 2009-04-29 | Microchips, Inc. | Drug delivery device and method for use with prosthetic device implantation |
US20100298808A1 (en) * | 2007-11-28 | 2010-11-25 | Janisys Limited | Method and a delivery device for administering an active substance to a subject |
US7833266B2 (en) | 2007-11-28 | 2010-11-16 | Boston Scientific Scimed, Inc. | Bifurcated stent with drug wells for specific ostial, carina, and side branch treatment |
US8989858B2 (en) | 2007-12-05 | 2015-03-24 | The Invention Science Fund I, Llc | Implant system for chemical modulation of neural activity |
US8165669B2 (en) | 2007-12-05 | 2012-04-24 | The Invention Science Fund I, Llc | System for magnetic modulation of neural conduction |
US8170659B2 (en) | 2007-12-05 | 2012-05-01 | The Invention Science Fund I, Llc | Method for thermal modulation of neural activity |
US8165668B2 (en) | 2007-12-05 | 2012-04-24 | The Invention Science Fund I, Llc | Method for magnetic modulation of neural conduction |
US8195287B2 (en) | 2007-12-05 | 2012-06-05 | The Invention Science Fund I, Llc | Method for electrical modulation of neural conduction |
US8180447B2 (en) | 2007-12-05 | 2012-05-15 | The Invention Science Fund I, Llc | Method for reversible chemical modulation of neural activity |
US8180446B2 (en) | 2007-12-05 | 2012-05-15 | The Invention Science Fund I, Llc | Method and system for cyclical neural modulation based on activity state |
US8170658B2 (en) | 2007-12-05 | 2012-05-01 | The Invention Science Fund I, Llc | System for electrical modulation of neural conduction |
EP2666510B1 (en) | 2007-12-20 | 2017-10-18 | University Of Southern California | Apparatus for controlled delivery of therapeutic agents |
US8277501B2 (en) | 2007-12-21 | 2012-10-02 | Boston Scientific Scimed, Inc. | Bi-stable bifurcated stent petal geometry |
US7869044B2 (en) * | 2008-01-16 | 2011-01-11 | Optotrace Technologies, Inc. | Optical sensing system based on a micro-array structure |
WO2009097468A2 (en) | 2008-01-29 | 2009-08-06 | Kliman Gilbert H | Drug delivery devices, kits and methods therefor |
US8231609B2 (en) | 2008-05-08 | 2012-07-31 | Minipumps, Llc | Drug-delivery pumps and methods of manufacture |
US9333297B2 (en) | 2008-05-08 | 2016-05-10 | Minipumps, Llc | Drug-delivery pump with intelligent control |
CN104353150A (en) | 2008-05-08 | 2015-02-18 | 迷你泵有限责任公司 | Implantable pums and cannulas therefor |
DE102008024447A1 (en) | 2008-05-20 | 2009-11-26 | Biotronik Crm Patent Ag | Implantable shock electrode lead and implantable defibrillation assembly |
US8932340B2 (en) | 2008-05-29 | 2015-01-13 | Boston Scientific Scimed, Inc. | Bifurcated stent and delivery system |
US20100061976A1 (en) * | 2008-07-24 | 2010-03-11 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method for treating or preventing osteoporosis by reducing follicle stimulating hormone to cyclic physiological levels in a mammalian subject |
WO2010014690A2 (en) * | 2008-07-31 | 2010-02-04 | Boston Scientific Scimed, Inc. | Medical devices for therapeutic agent delivery |
WO2010022252A2 (en) * | 2008-08-21 | 2010-02-25 | Third Rock Ventures | Device and method for drug evaluation and local treatment |
US20100136095A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems for modulating inflammation |
US20100137246A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Anti-inflammatory compositions and methods |
US20100136097A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems for modulating inflammation |
US20100135983A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Anti-inflammatory compositions and methods |
US20100136094A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems for modulating inflammation |
US20100137844A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Delivery devices for modulating inflammation |
US20100136096A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems for modulating inflammation |
US20110295090A1 (en) | 2008-12-04 | 2011-12-01 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems, devices, and methods including implantable devices with anti-microbial properties |
US8285387B2 (en) | 2008-12-12 | 2012-10-09 | Microchips, Inc. | Wireless communication with a medical implant |
US7838715B2 (en) * | 2009-01-21 | 2010-11-23 | Palo Alto Research Center Incorporated | Drug deactivation system and method of deactivating a drug using the same |
US9480795B2 (en) * | 2009-01-21 | 2016-11-01 | Palo Alto Research Center Incorporated | Sensor system for drug delivery device, drug delivery device having the same and method of using the same |
US8236238B2 (en) | 2009-01-21 | 2012-08-07 | Palo Alto Research Center Incorporated | Drug deactivation system |
US8167871B2 (en) | 2009-02-25 | 2012-05-01 | The Invention Science Fund I, Llc | Device for actively removing a target cell from blood or lymph of a vertebrate subject |
US8317737B2 (en) | 2009-02-25 | 2012-11-27 | The Invention Science Fund I, Llc | Device for actively removing a target component from blood or lymph of a vertebrate subject |
US8003521B2 (en) * | 2009-04-07 | 2011-08-23 | Micron Technology, Inc. | Semiconductor processing |
JP5643488B2 (en) * | 2009-04-28 | 2014-12-17 | 信越化学工業株式会社 | Manufacturing method of SOI wafer having low stress film |
EP2467797B1 (en) | 2009-08-18 | 2017-07-19 | MiniPumps, LLC | Electrolytic drug-delivery pump with adaptive control |
US10092691B2 (en) | 2009-09-02 | 2018-10-09 | Becton, Dickinson And Company | Flexible and conformal patch pump |
WO2011047271A1 (en) | 2009-10-16 | 2011-04-21 | Microchips, Inc. | Multi-channel potentiostat for biosensor arrays |
CN105825049A (en) | 2009-10-19 | 2016-08-03 | 提拉诺斯公司 | Integrated health data capture and analysis system |
EP2533737B1 (en) * | 2010-02-08 | 2014-01-08 | On Demand Therapeutics, Inc. | Low-permeability, laser-activated drug delivery device |
US8828246B2 (en) * | 2010-02-18 | 2014-09-09 | Anpac Bio-Medical Science Co., Ltd. | Method of fabricating micro-devices |
WO2011116151A2 (en) * | 2010-03-16 | 2011-09-22 | The Regents Of The University Of California | Enzyme-logic biosensing |
US9125625B2 (en) | 2010-06-10 | 2015-09-08 | The Regents Of The University Of California | Textile-based printable electrodes for electrochemical sensing |
US8895597B2 (en) | 2010-06-17 | 2014-11-25 | Violette Renard Recinos | Combination of local temozolomide with local BCNU |
US9953138B2 (en) | 2010-06-29 | 2018-04-24 | Codman Neuro Sciences Sarl | Drug component admixture library for a drug infusion delivery system |
EP2436446B1 (en) | 2010-10-04 | 2016-09-21 | F. Hoffmann-La Roche AG | Multi-chamber plate and method for filling it with a sample fluid |
US9687182B2 (en) | 2010-10-07 | 2017-06-27 | Biotronik Se & Co. Kg | Medical sensor system for detecting a feature in a body |
EP2438860A1 (en) | 2010-10-07 | 2012-04-11 | BIOTRONIK SE & Co. KG | Medical sensor system |
US8679093B2 (en) | 2010-11-23 | 2014-03-25 | Microchips, Inc. | Multi-dose drug delivery device and method |
EP2699266B1 (en) | 2011-04-21 | 2019-06-12 | Trustees Of Tufts College | Compositions and methods for stabilization of active agents |
KR101356671B1 (en) | 2011-08-22 | 2014-02-03 | 서울대학교산학협력단 | A microchip for sustained drug delivery |
US10427153B2 (en) | 2011-08-25 | 2019-10-01 | Microchips Biotech, Inc. | Systems and methods for sealing a plurality of reservoirs of a microchip element with a sealing grid |
SG11201400907PA (en) | 2011-08-25 | 2014-07-30 | Microchips Inc | Space-efficient containment devices and method of making same |
JP6563653B2 (en) | 2011-12-30 | 2019-08-21 | カイバー メディカル, インコーポレイテッド | Implantable devices and methods for evaluating active agents |
US20150005595A1 (en) | 2011-12-30 | 2015-01-01 | Kibur Medical, Inc. | Implantable devices and methods for evaluation of active agents |
US20130261372A1 (en) * | 2012-03-30 | 2013-10-03 | Elwha LLC, a limited liability company of the State of Delaware | Device, System, and Method for Delivery of Sugar Glass Stabilized Compositions |
SG11201504886SA (en) | 2012-12-21 | 2015-07-30 | Microchips Biotech Inc | Implantable medical device for minimally-invasive insertion |
US10617300B2 (en) * | 2013-02-13 | 2020-04-14 | The Board Of Trustees Of The University Of Illinois | Injectable and implantable cellular-scale electronic devices |
WO2014134323A1 (en) | 2013-02-28 | 2014-09-04 | Microchips, Inc | Implantable medical device for minimally-invasive insertion |
WO2014179398A1 (en) * | 2013-05-02 | 2014-11-06 | Elwha Llc | Implantable device for manipulating immune cells |
US20140330256A1 (en) * | 2013-05-02 | 2014-11-06 | Elwha Llc | Implantable Device for Manipulating Immune Cells |
US20140330244A1 (en) * | 2013-05-02 | 2014-11-06 | Elwha Llc | Implantable Device for Manipulating Immune Cells |
EP3030286B1 (en) | 2013-08-05 | 2019-10-09 | Cam Med LLC | Conformable patch pump |
EP3080589B1 (en) * | 2013-12-13 | 2019-05-22 | Abionic SA | Gas evacuation system for nanofluidic biosensor |
CA2946739A1 (en) * | 2014-04-25 | 2015-10-29 | Johnson & Johnson Vision Care, Inc. | Method and ophthalmic device with active agent release system |
US20160067466A1 (en) | 2014-09-05 | 2016-03-10 | Elwha LLC, a limited company of the State of Delaware | Systems, methods, and devices addressing the gastro-intestinal tract |
US10183154B2 (en) | 2014-09-05 | 2019-01-22 | Elwha Llc | Systems, methods, and devices addressing the gastro-intestinal tract |
US9937124B2 (en) | 2014-09-11 | 2018-04-10 | International Business Machines Corporation | Microchip substance delivery devices having low-power electromechanical release mechanisms |
US9808608B2 (en) | 2014-11-16 | 2017-11-07 | International Business Machines Corporation | Helical coil delivery device for active agent |
AU2016211330A1 (en) | 2015-01-28 | 2017-08-03 | Chrono Therapeutics Inc. | Drug delivery methods and systems |
WO2016130767A1 (en) | 2015-02-11 | 2016-08-18 | The Johns Hopkins University | Local delivery forms of acriflavine for treating tumors |
WO2017004576A1 (en) | 2015-07-02 | 2017-01-05 | The Board Of Trustees Of The University Of Illinois | Wireless optofluidic systems for programmable in vivo pharmacology and optogenetics |
US9867932B2 (en) | 2015-10-30 | 2018-01-16 | International Business Machines Corporation | Drug delivery device having a cavity sealed by a pressurized membrane |
US10881788B2 (en) | 2015-10-30 | 2021-01-05 | International Business Machines Corporation | Delivery device including reactive material for programmable discrete delivery of a substance |
EP3402558B1 (en) * | 2016-01-11 | 2023-11-29 | Syqe Medical Ltd. | Personal vaporizing device |
US11090404B2 (en) | 2016-05-19 | 2021-08-17 | The Procter & Gamble Company | Systems for dispensing fluid materials |
US10406336B2 (en) * | 2016-08-03 | 2019-09-10 | Neil S. Davey | Adjustable rate drug delivery implantable device |
US10620151B2 (en) | 2016-08-30 | 2020-04-14 | Analog Devices Global | Electrochemical sensor, and a method of forming an electrochemical sensor |
US11268927B2 (en) | 2016-08-30 | 2022-03-08 | Analog Devices International Unlimited Company | Electrochemical sensor, and a method of forming an electrochemical sensor |
CA3037337A1 (en) | 2016-09-19 | 2018-03-22 | Vaxess Technologies, Inc. | Vaccine formulations with increased stability |
WO2018089688A1 (en) | 2016-11-09 | 2018-05-17 | Jinjun Shi | Restoration of tumor suppression using mrna-based delivery system |
AU2017373857A1 (en) * | 2016-12-05 | 2019-06-13 | Morningside Venture Investments Limited | Transdermal drug delivery devices and methods |
WO2018129304A1 (en) | 2017-01-06 | 2018-07-12 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
US10864358B2 (en) * | 2017-05-02 | 2020-12-15 | Bernard Fryshman | Induction heating systems |
CN108968976B (en) | 2017-05-31 | 2022-09-13 | 心脏起搏器股份公司 | Implantable medical device with chemical sensor |
US10508755B2 (en) * | 2017-07-21 | 2019-12-17 | International Business Machines Corporation | Fluid delivery device with hydrophobic surface |
CN109381195B (en) | 2017-08-10 | 2023-01-10 | 心脏起搏器股份公司 | Systems and methods including electrolyte sensor fusion |
CN109419515B (en) | 2017-08-23 | 2023-03-24 | 心脏起搏器股份公司 | Implantable chemical sensor with staged activation |
CN109864746B (en) | 2017-12-01 | 2023-09-29 | 心脏起搏器股份公司 | Multimode analyte sensor for medical devices |
CN109864747B (en) | 2017-12-05 | 2023-08-25 | 心脏起搏器股份公司 | Multimode analyte sensor optoelectronic interface |
US11022579B2 (en) | 2018-02-05 | 2021-06-01 | Analog Devices International Unlimited Company | Retaining cap |
WO2019209290A1 (en) | 2018-04-25 | 2019-10-31 | Hewlett-Packard Development Company, L.P. | Selective release of material in thermally degradable capsule |
EP3801732A4 (en) | 2018-05-29 | 2022-04-27 | Morningside Venture Investments Limited | Drug delivery methods and systems |
US20220193384A1 (en) * | 2019-04-08 | 2022-06-23 | Universite De Lille | Cutaneous device for storing and releasing molecules, and corresponding method |
JP2022553563A (en) | 2019-11-01 | 2022-12-23 | ダーレ エムビー インコーポレイテッド | Two-step microchip drug delivery device and method |
KR20230043779A (en) | 2020-07-29 | 2023-03-31 | 바이오링크 인코포레이티드 | Continuous Analyte Monitoring System with Microneedle Array |
CA3184224A1 (en) | 2021-05-08 | 2022-11-17 | Joshua Ray Windmiller | Fault detection for microneedle array based continuous analyte monitoring device |
Citations (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5167625A (en) | 1990-10-09 | 1992-12-01 | Sarcos Group | Multiple vesicle implantable drug delivery system |
US5196002A (en) | 1990-10-09 | 1993-03-23 | University Of Utah Research Foundation | Implantable drug delivery system with piston acutation |
US5200051A (en) | 1988-11-14 | 1993-04-06 | I-Stat Corporation | Wholly microfabricated biosensors and process for the manufacture and use thereof |
US5252294A (en) | 1988-06-01 | 1993-10-12 | Messerschmitt-Bolkow-Blohm Gmbh | Micromechanical structure |
US5366454A (en) | 1993-03-17 | 1994-11-22 | La Corporation De L'ecole Polytechnique | Implantable medication dispensing device |
US5368704A (en) | 1993-08-06 | 1994-11-29 | Teknekron Corporation | Micro-electrochemical valves and method |
US5443508A (en) | 1993-03-01 | 1995-08-22 | Giampapa; Vincent C. | Subcutaneous implantable multiple agent delivery system |
US5490962A (en) | 1993-10-18 | 1996-02-13 | Massachusetts Institute Of Technology | Preparation of medical devices by solid free-form fabrication methods |
DE19716683C1 (en) | 1997-04-21 | 1998-06-04 | Fraunhofer Ges Forschung | Miniature encapsulation device for sensitive materials |
US5797898A (en) | 1996-07-02 | 1998-08-25 | Massachusetts Institute Of Technology | Microchip drug delivery devices |
JPH10285274A (en) | 1997-04-04 | 1998-10-23 | Murata Mach Ltd | Communication terminal equipment |
US6114658A (en) | 1996-03-15 | 2000-09-05 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Device for the encapsulated reception of a material |
US6178349B1 (en) | 1999-04-15 | 2001-01-23 | Medtronic, Inc. | Drug delivery neural stimulation device for treatment of cardiovascular disorders |
US6247485B1 (en) | 1996-11-21 | 2001-06-19 | Laboratoires D'hygiene Et De Dietetique (L.H.D.) | Miniature valve for filling the reservoir of an apparatus for the transdermal administration of medicine |
US6349232B1 (en) | 1997-07-11 | 2002-02-19 | Pets 'n People Ltd. | Apparatus and method for dispensing pet care substances |
US20020022826A1 (en) | 2000-08-14 | 2002-02-21 | Reynolds John R. | Burst electrode |
US20020072784A1 (en) | 2000-10-10 | 2002-06-13 | Sheppard Norman F. | Microchip reservoir devices using wireless transmission of power and data |
US20020072734A1 (en) | 2000-12-08 | 2002-06-13 | Pharmed Holding Gmbh | Chip systems for the controlled emission of substances having a chemosensory effect |
US20020099359A1 (en) | 2001-01-09 | 2002-07-25 | Santini John T. | Flexible microchip devices for ophthalmic and other applications |
WO2002056862A2 (en) | 2000-12-20 | 2002-07-25 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Microsystem for controlled dispensation of an active substance from a reservoir |
US20020107470A1 (en) | 1999-12-10 | 2002-08-08 | Richards Amy C. | Microchip devices for delivery of molecules and methods of fabrication thereof |
US20020111658A1 (en) | 2001-02-13 | 2002-08-15 | Greenberg Robert J. | Implantable retinal electrode array configuration for minimal retinal damage and method of reducing retinal stress |
US20020138067A1 (en) | 2000-10-11 | 2002-09-26 | Sheppard Norman F. | Microchip reservoir devices and facilitated corrosion of electrodes |
US20020183721A1 (en) | 2001-05-31 | 2002-12-05 | Santini John T. | Microchip devices with improved reservoir opening |
US6491666B1 (en) | 1999-11-17 | 2002-12-10 | Microchips, Inc. | Microfabricated devices for the delivery of molecules into a carrier fluid |
US20020187260A1 (en) | 2001-05-30 | 2002-12-12 | Sheppard Norman F. | Conformal coated microchip reservoir devices |
US20030010808A1 (en) | 2001-06-28 | 2003-01-16 | Uhland Scott A. | Methods for hermetically sealing microchip reservoir devices |
US20030036794A1 (en) | 1995-06-07 | 2003-02-20 | Cook Incorporated | Coated implantable medical device |
US6527762B1 (en) * | 1999-08-18 | 2003-03-04 | Microchips, Inc. | Thermally-activated microchip chemical delivery devices |
US20030069560A1 (en) | 2001-05-03 | 2003-04-10 | Massachusetts Eye And Ear Infirmary | Implantable drug delivery device and use thereof |
US6551838B2 (en) | 2000-03-02 | 2003-04-22 | Microchips, Inc. | Microfabricated devices for the storage and selective exposure of chemicals and devices |
US6571125B2 (en) | 2001-02-12 | 2003-05-27 | Medtronic, Inc. | Drug delivery device |
US6663615B1 (en) | 2001-09-04 | 2003-12-16 | The Ohio State University | Dual stage microvalve and method of use |
US20040043042A1 (en) | 2001-12-03 | 2004-03-04 | Johnson Audrey M. | Microscale lyophilization and drying methods for the stabilization of molecules |
US20040082937A1 (en) | 2002-09-04 | 2004-04-29 | Dennis Ausiello | Method and device for the controlled delivery of parathyroid hormone |
US6730072B2 (en) | 2000-05-30 | 2004-05-04 | Massachusetts Institute Of Technology | Methods and devices for sealing microchip reservoir devices |
Family Cites Families (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3692027A (en) | 1971-04-23 | 1972-09-19 | Everett H Ellinwood Jr | Implanted medication dispensing device and method |
US4003379A (en) | 1974-04-23 | 1977-01-18 | Ellinwood Jr Everett H | Apparatus and method for implanted self-powered medication dispensing |
US3952741A (en) | 1975-01-09 | 1976-04-27 | Bend Research Inc. | Controlled release delivery system by an osmotic bursting mechanism |
US4360019A (en) | 1979-02-28 | 1982-11-23 | Andros Incorporated | Implantable infusion device |
JPS57163309A (en) | 1981-04-01 | 1982-10-07 | Olympus Optical Co Ltd | Capsule apparatus for medical use |
GB8422876D0 (en) | 1984-09-11 | 1984-10-17 | Secr Defence | Silicon implant devices |
US4585652A (en) | 1984-11-19 | 1986-04-29 | Regents Of The University Of Minnesota | Electrochemical controlled release drug delivery system |
US5042975A (en) | 1986-07-25 | 1991-08-27 | Rutgers, The State University Of New Jersey | Iontotherapeutic device and process and iontotherapeutic unit dose |
US4731049A (en) | 1987-01-30 | 1988-03-15 | Ionics, Incorporated | Cell for electrically controlled transdermal drug delivery |
US5170801A (en) | 1990-10-02 | 1992-12-15 | Glaxo Inc. | Medical capsule device actuated by radio-frequency (rf) signal |
US5493177A (en) | 1990-12-03 | 1996-02-20 | The Regents Of The University Of California | Sealed micromachined vacuum and gas filled devices |
US5279607A (en) | 1991-05-30 | 1994-01-18 | The State University Of New York | Telemetry capsule and process |
EP0604504A4 (en) | 1991-08-26 | 1995-05-17 | Univ Rutgers | Iontotherapeutic device and process. |
US5429822A (en) | 1992-03-13 | 1995-07-04 | Cambridge Scientific, Inc. | Biodegradable bursting release system |
US5756117A (en) | 1992-04-08 | 1998-05-26 | International Medical Asscociates, Inc. | Multidose transdermal drug delivery system |
US5318557A (en) | 1992-07-13 | 1994-06-07 | Elan Medical Technologies Limited | Medication administering device |
US5380272A (en) | 1993-01-28 | 1995-01-10 | Scientific Innovations Ltd. | Transcutaneous drug delivery applicator |
US5368588A (en) | 1993-02-26 | 1994-11-29 | Bettinger; David S. | Parenteral fluid medication reservoir pump |
US5427585A (en) | 1993-03-29 | 1995-06-27 | Bettinger; David S. | On-demand iontophoretic system |
US5474527A (en) * | 1993-03-29 | 1995-12-12 | Bettinger; David S. | Positive displacement transdermal system |
US5900160A (en) | 1993-10-04 | 1999-05-04 | President And Fellows Of Harvard College | Methods of etching articles via microcontact printing |
US6129685A (en) | 1994-02-09 | 2000-10-10 | The University Of Iowa Research Foundation | Stereotactic hypothalamic obesity probe |
US5770076A (en) | 1994-03-07 | 1998-06-23 | The Regents Of The University Of California | Micromachined capsules having porous membranes and bulk supports |
US5893974A (en) | 1994-03-07 | 1999-04-13 | Regents Of University Of California | Microfabricated capsules for immunological isolation of cell transplants |
US5660680A (en) | 1994-03-07 | 1997-08-26 | The Regents Of The University Of California | Method for fabrication of high vertical aspect ratio thin film structures |
US5798042A (en) | 1994-03-07 | 1998-08-25 | Regents Of The University Of California | Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters |
US5985328A (en) | 1994-03-07 | 1999-11-16 | Regents Of The University Of California | Micromachined porous membranes with bulk support |
US5651900A (en) | 1994-03-07 | 1997-07-29 | The Regents Of The University Of California | Microfabricated particle filter |
US5971931A (en) | 1994-03-29 | 1999-10-26 | Raff; Gilbert Lewis | Biologic micromonitoring methods and systems |
US5504026A (en) | 1995-04-14 | 1996-04-02 | Analog Devices, Inc. | Methods for planarization and encapsulation of micromechanical devices in semiconductor processes |
US5992769A (en) | 1995-06-09 | 1999-11-30 | The Regents Of The University Of Michigan | Microchannel system for fluid delivery |
SE9502258D0 (en) | 1995-06-21 | 1995-06-21 | Pharmacia Biotech Ab | Method for the manufacture of a membrane-containing microstructure |
US5662689A (en) | 1995-09-08 | 1997-09-02 | Medtronic, Inc. | Method and apparatus for alleviating cardioversion shock pain |
US5939923A (en) | 1995-12-27 | 1999-08-17 | Texas Instruments Incorporated | Selectable low power signal line and method of operation |
WO1997029802A2 (en) | 1996-02-20 | 1997-08-21 | Advanced Bionics Corporation | Improved implantable microstimulator and systems employing the same |
US5736154A (en) * | 1996-03-11 | 1998-04-07 | Fuisz Technologies Ltd. | Transdermal delivery system |
FI965067A0 (en) | 1996-12-17 | 1996-12-17 | Jvs Polymers Oy | Implantmaterial som kan plastiseras |
US5938923A (en) | 1997-04-15 | 1999-08-17 | The Regents Of The University Of California | Microfabricated filter and capsule using a substrate sandwich |
US5949187A (en) | 1997-07-29 | 1999-09-07 | Motorola, Inc. | Organic electroluminescent device with plural microcavities |
US5961492A (en) * | 1997-08-27 | 1999-10-05 | Science Incorporated | Fluid delivery device with temperature controlled energy source |
US5842787A (en) * | 1997-10-09 | 1998-12-01 | Caliper Technologies Corporation | Microfluidic systems incorporating varied channel dimensions |
US6081736A (en) | 1997-10-20 | 2000-06-27 | Alfred E. Mann Foundation | Implantable enzyme-based monitoring systems adapted for long term use |
US6001090A (en) * | 1998-02-09 | 1999-12-14 | Lenhart; Douglas | Thermal pharmaceutical delivery system |
US6757560B1 (en) | 1999-04-09 | 2004-06-29 | Novosis Pharma Ag | Transdermal delivery system (TDS) with electrode network |
US6161047A (en) | 1998-04-30 | 2000-12-12 | Medtronic Inc. | Apparatus and method for expanding a stimulation lead body in situ |
US6319241B1 (en) | 1998-04-30 | 2001-11-20 | Medtronic, Inc. | Techniques for positioning therapy delivery elements within a spinal cord or a brain |
US6941171B2 (en) | 1998-07-06 | 2005-09-06 | Advanced Bionics Corporation | Implantable stimulator methods for treatment of incontinence and pain |
US6908770B1 (en) | 1998-07-16 | 2005-06-21 | Board Of Regents, The University Of Texas System | Fluid based analysis of multiple analytes by a sensor array |
US6201980B1 (en) | 1998-10-05 | 2001-03-13 | The Regents Of The University Of California | Implantable medical sensor system |
US6232150B1 (en) | 1998-12-03 | 2001-05-15 | The Regents Of The University Of Michigan | Process for making microstructures and microstructures made thereby |
US6289237B1 (en) | 1998-12-22 | 2001-09-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Apparatus for energizing a remote station and related method |
US6923784B2 (en) | 1999-04-30 | 2005-08-02 | Medtronic, Inc. | Therapeutic treatment of disorders based on timing information |
US6587719B1 (en) | 1999-07-01 | 2003-07-01 | Cyberonics, Inc. | Treatment of obesity by bilateral vagus nerve stimulation |
US6804558B2 (en) | 1999-07-07 | 2004-10-12 | Medtronic, Inc. | System and method of communicating between an implantable medical device and a remote computer system or health care provider |
US6334859B1 (en) * | 1999-07-26 | 2002-01-01 | Zuli Holdings Ltd. | Subcutaneous apparatus and subcutaneous method for treating bodily tissues with electricity or medicaments |
US6384353B1 (en) | 2000-02-01 | 2002-05-07 | Motorola, Inc. | Micro-electromechanical system device |
DE60134878D1 (en) | 2000-10-26 | 2008-08-28 | Medtronic Inc | DEVICE FOR THE ELECTRICAL STIMULATION OF THE NERVOUS SYSTEM FOR THE THERAPY OF VENTRICULAR MALFUNCTIONS, HEART FAILURES AND OTHER CARDIAL STATES |
DE60139411D1 (en) | 2000-10-26 | 2009-09-10 | Medtronic Inc | DEVICE FOR MINIMIZING THE EFFECTS OF A HEART INJURY |
JP2004512105A (en) | 2000-10-26 | 2004-04-22 | メドトロニック・インコーポレーテッド | Method and apparatus for protecting heart tissue from seizures |
WO2002056940A2 (en) | 2001-01-22 | 2002-07-25 | Integrated Sensing Systems, Inc. | Sensing catheter system and method of fabrication |
US20020144548A1 (en) | 2001-04-06 | 2002-10-10 | Cohn Michael B. | High precision accelerometer |
US6733485B1 (en) | 2001-05-25 | 2004-05-11 | Advanced Bionics Corporation | Microstimulator-based electrochemotherapy methods and systems |
JP2004533297A (en) | 2001-05-29 | 2004-11-04 | メドトロニック・インコーポレーテッド | Closed loop neuromodulation system for prevention and treatment of heart disease |
AU2003279842A1 (en) * | 2002-10-04 | 2004-05-04 | Microchips, Inc. | Medical device for controlled drug delivery and cardiac monitoring and/or stimulation |
-
2000
- 2000-08-11 DE DE60018582T patent/DE60018582T2/en not_active Expired - Lifetime
- 2000-08-11 JP JP2001516504A patent/JP4397558B2/en not_active Expired - Fee Related
- 2000-08-11 CA CA002381951A patent/CA2381951A1/en not_active Abandoned
- 2000-08-11 AT AT00954046T patent/ATE290364T1/en not_active IP Right Cessation
- 2000-08-11 WO PCT/US2000/022215 patent/WO2001012157A1/en active IP Right Grant
- 2000-08-11 AU AU66394/00A patent/AU6639400A/en not_active Abandoned
- 2000-08-11 EP EP00954046A patent/EP1210064B1/en not_active Expired - Lifetime
- 2000-08-11 US US09/638,109 patent/US6527762B1/en not_active Expired - Lifetime
-
2003
- 2003-01-13 US US10/341,305 patent/US6669683B2/en not_active Expired - Lifetime
- 2003-12-29 US US10/747,900 patent/US7473248B2/en not_active Expired - Fee Related
-
2007
- 2007-06-18 JP JP2007160766A patent/JP2007283117A/en active Pending
-
2009
- 2009-01-05 US US12/348,609 patent/US8016817B2/en not_active Expired - Fee Related
Patent Citations (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5252294A (en) | 1988-06-01 | 1993-10-12 | Messerschmitt-Bolkow-Blohm Gmbh | Micromechanical structure |
US5200051A (en) | 1988-11-14 | 1993-04-06 | I-Stat Corporation | Wholly microfabricated biosensors and process for the manufacture and use thereof |
US5196002A (en) | 1990-10-09 | 1993-03-23 | University Of Utah Research Foundation | Implantable drug delivery system with piston acutation |
US5167625A (en) | 1990-10-09 | 1992-12-01 | Sarcos Group | Multiple vesicle implantable drug delivery system |
US5443508A (en) | 1993-03-01 | 1995-08-22 | Giampapa; Vincent C. | Subcutaneous implantable multiple agent delivery system |
US5366454A (en) | 1993-03-17 | 1994-11-22 | La Corporation De L'ecole Polytechnique | Implantable medication dispensing device |
US5368704A (en) | 1993-08-06 | 1994-11-29 | Teknekron Corporation | Micro-electrochemical valves and method |
US5490962A (en) | 1993-10-18 | 1996-02-13 | Massachusetts Institute Of Technology | Preparation of medical devices by solid free-form fabrication methods |
US20030036794A1 (en) | 1995-06-07 | 2003-02-20 | Cook Incorporated | Coated implantable medical device |
US6114658A (en) | 1996-03-15 | 2000-09-05 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Device for the encapsulated reception of a material |
US6123861A (en) | 1996-07-02 | 2000-09-26 | Massachusetts Institute Of Technology | Fabrication of microchip drug delivery devices |
US5797898A (en) | 1996-07-02 | 1998-08-25 | Massachusetts Institute Of Technology | Microchip drug delivery devices |
US6247485B1 (en) | 1996-11-21 | 2001-06-19 | Laboratoires D'hygiene Et De Dietetique (L.H.D.) | Miniature valve for filling the reservoir of an apparatus for the transdermal administration of medicine |
JPH10285274A (en) | 1997-04-04 | 1998-10-23 | Murata Mach Ltd | Communication terminal equipment |
DE19716683C1 (en) | 1997-04-21 | 1998-06-04 | Fraunhofer Ges Forschung | Miniature encapsulation device for sensitive materials |
US6349232B1 (en) | 1997-07-11 | 2002-02-19 | Pets 'n People Ltd. | Apparatus and method for dispensing pet care substances |
US6178349B1 (en) | 1999-04-15 | 2001-01-23 | Medtronic, Inc. | Drug delivery neural stimulation device for treatment of cardiovascular disorders |
US6669683B2 (en) | 1999-08-18 | 2003-12-30 | Microchips, Inc. | Thermally-activated microchip chemical delivery devices |
US6527762B1 (en) * | 1999-08-18 | 2003-03-04 | Microchips, Inc. | Thermally-activated microchip chemical delivery devices |
US6537256B2 (en) | 1999-11-17 | 2003-03-25 | Microchips, Inc. | Microfabricated devices for the delivery of molecules into a carrier fluid |
US6656162B2 (en) | 1999-11-17 | 2003-12-02 | Microchips, Inc. | Implantable drug delivery stents |
US6491666B1 (en) | 1999-11-17 | 2002-12-10 | Microchips, Inc. | Microfabricated devices for the delivery of molecules into a carrier fluid |
US20020107470A1 (en) | 1999-12-10 | 2002-08-08 | Richards Amy C. | Microchip devices for delivery of molecules and methods of fabrication thereof |
US6551838B2 (en) | 2000-03-02 | 2003-04-22 | Microchips, Inc. | Microfabricated devices for the storage and selective exposure of chemicals and devices |
US20030104590A1 (en) | 2000-03-02 | 2003-06-05 | Santini, John T. | Microfabricated devices for the storage and selective exposure of chemicals and devices |
US6730072B2 (en) | 2000-05-30 | 2004-05-04 | Massachusetts Institute Of Technology | Methods and devices for sealing microchip reservoir devices |
US20020022826A1 (en) | 2000-08-14 | 2002-02-21 | Reynolds John R. | Burst electrode |
US20020072784A1 (en) | 2000-10-10 | 2002-06-13 | Sheppard Norman F. | Microchip reservoir devices using wireless transmission of power and data |
US20020138067A1 (en) | 2000-10-11 | 2002-09-26 | Sheppard Norman F. | Microchip reservoir devices and facilitated corrosion of electrodes |
US20020072734A1 (en) | 2000-12-08 | 2002-06-13 | Pharmed Holding Gmbh | Chip systems for the controlled emission of substances having a chemosensory effect |
WO2002056862A2 (en) | 2000-12-20 | 2002-07-25 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Microsystem for controlled dispensation of an active substance from a reservoir |
US20020099359A1 (en) | 2001-01-09 | 2002-07-25 | Santini John T. | Flexible microchip devices for ophthalmic and other applications |
US6571125B2 (en) | 2001-02-12 | 2003-05-27 | Medtronic, Inc. | Drug delivery device |
US20020111658A1 (en) | 2001-02-13 | 2002-08-15 | Greenberg Robert J. | Implantable retinal electrode array configuration for minimal retinal damage and method of reducing retinal stress |
US20030069560A1 (en) | 2001-05-03 | 2003-04-10 | Massachusetts Eye And Ear Infirmary | Implantable drug delivery device and use thereof |
US20020187260A1 (en) | 2001-05-30 | 2002-12-12 | Sheppard Norman F. | Conformal coated microchip reservoir devices |
US20020183721A1 (en) | 2001-05-31 | 2002-12-05 | Santini John T. | Microchip devices with improved reservoir opening |
US20030010808A1 (en) | 2001-06-28 | 2003-01-16 | Uhland Scott A. | Methods for hermetically sealing microchip reservoir devices |
US6663615B1 (en) | 2001-09-04 | 2003-12-16 | The Ohio State University | Dual stage microvalve and method of use |
US20040043042A1 (en) | 2001-12-03 | 2004-03-04 | Johnson Audrey M. | Microscale lyophilization and drying methods for the stabilization of molecules |
US20040082937A1 (en) | 2002-09-04 | 2004-04-29 | Dennis Ausiello | Method and device for the controlled delivery of parathyroid hormone |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9024394B2 (en) | 2013-05-22 | 2015-05-05 | Transient Electronics, Inc. | Controlled transformation of non-transient electronics |
US10737090B2 (en) | 2017-07-11 | 2020-08-11 | Medtronic, Inc. | External defibrillation electrode conductive electrolyte dispersal pad |
Also Published As
Publication number | Publication date |
---|---|
EP1210064B1 (en) | 2005-03-09 |
DE60018582D1 (en) | 2005-04-14 |
US20040143236A1 (en) | 2004-07-22 |
CA2381951A1 (en) | 2001-02-22 |
US20090112188A1 (en) | 2009-04-30 |
WO2001012157A1 (en) | 2001-02-22 |
JP2007283117A (en) | 2007-11-01 |
US6669683B2 (en) | 2003-12-30 |
US20030105455A1 (en) | 2003-06-05 |
US7473248B2 (en) | 2009-01-06 |
ATE290364T1 (en) | 2005-03-15 |
DE60018582T2 (en) | 2006-01-19 |
JP2003506477A (en) | 2003-02-18 |
EP1210064A1 (en) | 2002-06-05 |
AU6639400A (en) | 2001-03-13 |
US6527762B1 (en) | 2003-03-04 |
JP4397558B2 (en) | 2010-01-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US8016817B2 (en) | Device for controlling exposure of reservoir contents to surroundings | |
US7892221B2 (en) | Method of controlled drug delivery from implant device | |
EP0914092B1 (en) | Microchip drug delivery devices | |
US6875208B2 (en) | Microchip devices with improved reservoir opening | |
WO1998000107A9 (en) | Microchip drug delivery devices | |
US6973718B2 (en) | Methods for conformal coating and sealing microchip reservoir devices | |
ES2420279T3 (en) | Microfabricated devices and methods for storage and selective exposure of chemicals | |
US6953455B2 (en) | Medicine delivery system | |
EP1229901B1 (en) | Microfabricated devices for the delivery of molecules into a carrier fluid | |
US20040020173A1 (en) | Low temperature anodic bonding method using focused energy for assembly of micromachined systems |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
ZAAA | Notice of allowance and fees due |
Free format text: ORIGINAL CODE: NOA |
|
ZAAB | Notice of allowance mailed |
Free format text: ORIGINAL CODE: MN/=. |
|
ZAAA | Notice of allowance and fees due |
Free format text: ORIGINAL CODE: NOA |
|
STCF | Information on status: patent grant |
Free format text: PATENTED CASE |
|
FPAY | Fee payment |
Year of fee payment: 4 |
|
AS | Assignment |
Owner name: MICROCHIPS BIOTECH, INC., MASSACHUSETTS Free format text: CHANGE OF NAME;ASSIGNOR:MICROCHIPS, INC.;REEL/FRAME:039027/0671 Effective date: 20140912 |
|
MAFP | Maintenance fee payment |
Free format text: PAYMENT OF MAINTENANCE FEE, 8TH YR, SMALL ENTITY (ORIGINAL EVENT CODE: M2552); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY Year of fee payment: 8 |
|
FEPP | Fee payment procedure |
Free format text: MAINTENANCE FEE REMINDER MAILED (ORIGINAL EVENT CODE: REM.); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY |
|
LAPS | Lapse for failure to pay maintenance fees |
Free format text: PATENT EXPIRED FOR FAILURE TO PAY MAINTENANCE FEES (ORIGINAL EVENT CODE: EXP.); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY |
|
STCH | Information on status: patent discontinuation |
Free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362 |
|
FP | Lapsed due to failure to pay maintenance fee |
Effective date: 20230913 |