US6375981B1 - Modified starch as a replacement for gelatin in soft gel films and capsules - Google Patents
Modified starch as a replacement for gelatin in soft gel films and capsules Download PDFInfo
- Publication number
- US6375981B1 US6375981B1 US09/584,413 US58441300A US6375981B1 US 6375981 B1 US6375981 B1 US 6375981B1 US 58441300 A US58441300 A US 58441300A US 6375981 B1 US6375981 B1 US 6375981B1
- Authority
- US
- United States
- Prior art keywords
- composition
- starch
- film
- group
- gum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
- C08J5/18—Manufacture of films or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L3/00—Compositions of starch, amylose or amylopectin or of their derivatives or degradation products
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2303/00—Characterised by the use of starch, amylose or amylopectin or of their derivatives or degradation products
Definitions
- This invention relates to starch compositions useful in forming flexible films. More particularly, it relates to film-forming compositions containing certain modified starches.
- Gelatin is a protein that forms thermo-reversible films.
- Gel masses composed of gelatin and a plasticizer such as glycerin are formulated to be liquid above room temperature, form a film when cast on a cooled surface, and re-melt when exposed to higher temperatures again. This ability to re-tackify enables encapsulation of liquid materials in gelatin soft capsules.
- Films formed from plasticized gelatin set very quickly and have high wet film strength. They are also very elastic with good clarity. Plasticized gelatin also has a relatively low viscosity, even when used at high solids concentrations. In addition, when gelatin is in the presence of water at room temperature, it swells but does not go into solution until heat is applied.
- the soft gel composition In the manufacture of soft gel films and capsules, the soft gel composition must possess the properties of good wet and dry film strength, insolubility in cold water, oil, and alcohol, solubility in hot water, temperature and pressure sealability, film clarity, film flexibility, edibility, inertness to drugs or other materials to be encapsulated, and rapid setting from a hot liquid to form a gel.
- the soft gel films In the manufacture of photographic elements, the soft gel films must possess the qualities of clarity, strength, setting power, flexibility, and non-interaction with other chemicals in the photographic film.
- gelatin Although gelatin is useful in soft gel applications because of its rapid gelling ability, excellent film forming properties, and ability to impart oxygen impermeability, it has the disadvantages of high cost, limited availability, non-kosher status for food products and, at times, batch property variations. Because of these shortcomings, those industries where the need for gelatin is greatest have long sought means for replacing gelatin.
- a useful gelatin replacer must be compatible with common plasticizers and fill materials used in the industry, and must provide properties equivalent to those of the gelatin which it is replacing for a particular application, e.g., film or binding strength in the pharmaceutical industry, phototransmissibility and resistance to abrasion in the photographic industry, and binding strength in the adhesive industry.
- One aspect of the present invention is a film-forming composition that comprises starch material selected from the group consisting of modified starch and waxy starch; gum; and plasticizer.
- the modified starch or waxy starch has a dextrose equivalent (DE) of less than about 1, and preferably has no measurable DE.
- DE dextrose equivalent
- This composition can be, but is not required to be, 100% gelatin-free.
- the composition can be used as a gelatin replacement, or as an extender in gelatin formulations.
- the composition typically will be prepared with water, and have a solids concentration of about 30-70% by weight.
- the solids in the composition preferably comprise 25-75% starch material, 25-75% plasticizer, and 0.1-15% gum.
- the weight ratio of gum to starch is from about 0.1:1 to about 1:1, and the weight ratio of starch and gum to plasticizer is from about 1:0.8 to about 1:3.
- the starch material preferably comprises starch which has been chemically modified with a monoreactive moiety to a degree of substitution of least about 0.015. It is also preferred that the starch material has an average molecular weight between about 100,000-2,000,000.
- the starch material is selected from the group consisting of ether and ester derivatives of starch, such as hydroxypropyl, hydroxyethyl, succinate, and octenyl succinate starch.
- One specific embodiment of the invention comprises hydroxypropylated potato starch having a degree of substitution of about 0.015-0.30 and a molecular weight of about 100,000-2,000,000.
- the gum preferably is selected from the group consisting of carrageenan, locust bean, xanthan, gellan, agar, alginates, guar, gum arabic, and pectin.
- the plasticizer preferably comprises at least one polyol, such as glycerol, sorbitol, maltitol, or a mixture of one or more of these.
- the composition of the present invention can optionally also comprise at least one monovalent or divalent cation, such as sodium, potassium, and calcium salts, or mixtures thereof.
- Another aspect of the invention is an edible film that comprises the above-described starch-based composition, usually with much of the water removed.
- Yet another aspect of the invention is a soft gel capsule that comprises a sealed capsule wall and a first substance that is encapsulated by the sealed capsule wall.
- the capsule wall comprises the above-described starch-based composition.
- the film or the capsule wall consists essentially of the combination of starch material, gum, and plasticizer.
- the first substance encapsulated by the capsule wall can be any of a variety of materials which have been encapsulated by gelatin in the past. Many such substances are edible, including drugs, vitamins, nutritional supplements, and pre-measured food ingredients such as flavorings. It can also comprise, for example, photographic or dye solutions.
- Another aspect of the invention is a method of encapsulating a first substance.
- This method comprises the steps of: providing a first substance and an edible film as described above; and encapsulating the first substance in the film.
- the film used in this method has been formed on a surface having a temperature of at least about 100° F.
- One object of this invention to provide an economical means for replacing gelatin in compositions utilized in the production of soft gel for food, pharmaceutical, and industrial applications. It is a further object of this invention to provide starch-based materials which are compatible with the existing application equipment used for manufacture of the various products which are primarily comprised of gelatin films.
- modified starches that have been chemically modified with monoreactive moieties to a degree of substitution of at least 0.015 DS, and degraded to molecular weights between 100,000 and 2,000,000, or, alternatively, waxy starches, when combined with gum and plasticizing agents, are a highly functional replacement for gelatin in soft gel film forming applications.
- the presence of gum increases the rate of film formation and enhances film strength.
- the starch and gum preferably are mixed with plasticizers at ratios ranging from about 1 part starch and gum to about 0.8-3 parts plasticizer.
- the total solids in the composition preferably range from about 30 to 70% weight.
- Edible films are prepared by blending together the starch, gum, plasticizer, and water, and heating the mixture to a temperature and for a time sufficient to gelatinize the starch fully, (e.g., 80-100 ° C. for 10-60 min). A vacuum can be used either during or after cooking to remove entrained air and improve film properties. Additional materials may be added to the mixture of starch and plasticizer in order to impart improved functionality.
- properties of this system can be modified by the inclusion of various mono and divalent cations, including but not limited to sodium, potassium, and calcium.
- the mixture is then sheeted, while hot, to form a thin film.
- This film can be formed into soft gel capsules, encapsulating pharmaceutical, nutritional, photographic, or other materials, using well-known techniques.
- modified starch-based compositions of the present invention provide an acceptable balance of critical variables including mass viscosity and pot life, film rate, wet film strength, dry film strength and flexibility, and thermo-reversibility.
- wet film strength is significantly improved by increasing the temperature of the surface on which the film is formed. It is preferred in the present invention to use film-forming surface temperatures of about 100° F. or greater. Commercial capsule filming drum temperatures are often set around 50° F. for gelatin filming, but can easily be adjusted to 100-110° F. Breaking strengths can be increased by as much as 500% by increasing surface temperature from 53° F. to 150° F. Films cast at 105° F. can have as much as twice the breaking strength films cast on 53° F. surfaces.
- the gum component of the composition consists essentially of 50% kappa carrageenan and 50% iota carrageenan.
- This combination can increase film strength by as much as 50% over films formed with 100% kappa carrageenan as the gum component, increase film elasticity, reduce the viscosity of the hot mass, lower the minimum temperature at which the gelled mass can be handled in liquid form, and lower the gel-setting temperature of the mass.
- This composition also broadens the temperature range over which the mass gels, which can improve the ease of film sealing.
- the present invention has a number of benefits.
- One advantage of the invention is that it is a simple, cost-effective, dependable, intrinsically safe, Kosher, and efficient means for replacing the gelatin used in soft gel capsule compositions.
- Another advantage of the invention is that the preparation of the starch-based compositions can be carried out by ordinary means with conventional manufacturing apparatus.
- the resulting compositions can be utilized in any commercial process requiring gelatin and to which conventional coating and drying methods are adaptable.
- Examples of end-product uses for the compositions of the present invention include encapsulated bath beads, paint balls, and pharmaceuticals. Therefore, the present invention provides a novel, efficient means for replacing gelatin in these and other applications.
- FIG. 1 is a graph showing the effect of the temperature of the surface on which a film is formed on the strength of that film.
- FIG. 2 is a graph showing the effect of temperature on flow and gelation for compositions containing different types of carrageenan.
- FIG. 3 is a graph showing the effect of mass solids percentage on the flowability of compositions containing different types of carrageenan.
- modified starches examples include non-retrograding starches derived by chemical modification of starch from any plant source, including corn, waxy maize, potato, sweet potato, wheat, rice, sago, tapioca, sorghum, high amylose corn, and the like.
- the particular starch chosen will depend on its performance, availability, and cost.
- the starch should have a DE less than about 1, and preferably has no measurable DE (using the Lane-Eynon method).
- useful modified starches are the common ether and ester derivatives of starch, including but not limited to hydroxypropyl, hydroxyethyl, succinate, and octenyl succinate starch derivatives.
- modified starches suitable for use in the practice of this invention are the thermally converted, fluidity or thin boiling type products derived from the aforementioned types of chemically modified starches.
- Such materials may be of lower molecular weight, prepared by heating the modified starch alone or by subjecting the starch to a hydrolytic acid and/or heat treatment, or by any other known method designed for the thermal conversion of the starch, such as enzymic heat treatment.
- Preferred modified starches are the hydroxypropyl derivatives of potato starch having a degree of substitution from 0.015-0.30 ds and a molecular weight of from 100,000 to 2,000,000.
- the branches of the amylopectin replace the function of the ether or ester substituents; these starches are functional in the present invention without additional chemical modification, although their properties are not impaired by additional modification, and are enhanced by molecular weight reduction.
- Suitable plasticizers include, but are not limited to, glycerol, sorbitol, and maltitol.
- Suitable hydrocolloid gums include carrageenan, locust bean gum, xanthan gum, gellan gum, agar, alginates, guar gum, gum arabic, and pectin.
- compositions can be enhanced by the addition of certain cations, including but not limited to sodium, potassium, and calcium.
- certain cations including but not limited to sodium, potassium, and calcium.
- a variety of optional ingredients may be incorporated into the starch compositions of this invention, before, during, or after cooking the starch.
- suitable additives which may be utilized are preservatives, colorants, flavoring agents, hardeners, antifoggers, sensitizers, and spreading agents. The inclusion of such additives has no adverse effect upon the properties exhibited by the novel starch-based compositions of the present invention.
- a composition of the present invention is formed by combining the dry solids (i.e., the modified starch or waxy starch, gum, and plasticizer, plus any other additives), slurrying in water, and heating at a temperature and for a time sufficient to gelatinize the starch. Optionally, this can take place under a vacuum. Films can be formed from these starch-based compositions by any conventional method designed to solubilize and deposit a continuous coating or layer of the solution onto a substrate or mold of any form. Among the suitable coating techniques are spraying, dipping, air knife, trailing blade, reverse and direct roll coaters, etc.
- a film such as an overcoating or capsule shell, may then be formed by drying the coated solution to a desired moisture content, using any means suitable for the particular purpose. Suitable conventional means include warm or cold air impingement, low humidity chamber or oven drying, etc.
- soft gel capsules are prepared by casting a film of the gelatin solution and then continuously passing two ribbons of the film between two opposing rollers, each of which is equipped with an internal vacuum that draws in the film through half capsule wells engraved in its surface. The capsule contents are deposited between the shell halves as they are formed and sealed. The process is continuous, ending with the filled capsules being automatically conveyed to and through a drying unit that partially dries the capsule. Drying is completed in warm air tunnels.
- the films of the present invention can be re-melted, and two or more of these re-melted films can be joined to form a seal.
- the invention is particularly efficacious in the soft gel capsule manufacturing process that calls for film-forming materials, but it is not limited thereto.
- novel starch formulations particularly their ability to serve as a total replacement for gelatin, permit them to be used in a wide range of applications.
- compositions of the present invention can also be utilized as extenders in gelatin compositions such as creams, emulsions, binders, adhesives, etc. Further compositions of the present invention can be used in the replacement of gelatin in hard shell capsule manufacturing.
- compositions were prepared containing the component amounts given in Examples 1-7 on a dry solids basis.
- Starch molecular weights were measured by gel permeation chromatography and weight averaged.
- the starch, plasticizer, and gum, if used, were mixed with sufficient deionized water (except where indicated) to give a total slurry mass of 35 g.
- the components were mixed together in the cup of a Rapid Visco Analyzer (Model RVA-4D, Foss Food Technology, Eden Prairie, Minn.) (hereafter referred to as “RVA”), and heated, using 160 rpm stirring, to 98° C. over 4.5 minutes.
- RVA Rapid Visco Analyzer
- the film samples were prepared by casting a layer of the test solution at about 1 80° F. (82° C.) onto a Teflon-coated piece of glass (approximately 9 in ⁇ 13 in). The bottom of the glass was in contact with circulating cold water so that the surface temperature of the glass was 52° C. The film was formed by pouring the hot paste onto the Teflon surface and then quickly drawing the paste across the glass using a Bird Applicator or similar device, the gap width of which could be adjusted to control film thickness. Wet film thicknesses were typically 0.5-0.8 mm. The films were cast, dried, and aged in a room controlled to 70° F. and 25-30% relative humidity.
- the viscosity of the starch mixture was measured by the RVA instrument, which records viscosity throughout the cook.
- Pot life was evaluated by transferring the hot paste into preheated glass jars with screw lids, and placing these in a 180° F. oven.
- the fluidity of the mass was evaluated after 2 hours by tipping the jars upside down and assigning a flow rating of 0-5.
- a mass that flowed with the ease of water was given a rating of 5; a mass which did not flow at all was given a rating of 0.
- the oven temperature was then lowered by 10° C. and the samples allowed to equilibrate for 2 hours, and then their flow properties re-assessed.
- the oven was lowered in 10° F. increments until all samples had a flow rating of zero—that is, they had all gelled.
- the films were evaluated for rate of filming using a Gardco Electronic Multicycle Circular Drying Time Recorder, and following test method procedure ASTM D 5895.
- the recorder was placed above the wet film, and a stylus was lowered onto the surface of the film and allowed to rotate for a defined time of 10 minutes.
- Three points were determined from this test: tack free, dry hard, and dry through.
- Tack free is defined as the point in the path made by the stylus on the film where the continuous track ends and a discontinuous track or tear begins.
- Dry hard is the point in the path where the stylus no longer tears the film, and only leaves a visible trace. Dry through is reached when the stylus no longer leaves any visible track on the film.
- the tensile strength of the wet film was measured using a Stable Microsystems TA-XT2 Texture Analyzer. To do this, 0.5 in ⁇ 8 in strips were cut from the wet film 5 minutes after it was cast and these were loaded onto the Texture Analyzer. The tensile test was started 15 minutes after the film was cast.
- a formulation was prepared having the following composition (on an as-is basis):
- the total solids of the composition was 44%.
- the starch to carrageenan ratio was 6.75/1, and the ratio of plasticizer to thickener (starch plus carrageenan) was 1.6/1.
- the plasticizer was composed of 75% Sorbitol Special and 25% glycerine. The components were mixed together and then heated to 98° C. for 15 minutes (or to 92° C. for 30 minutes), then poured hot onto a surface and drawn down into a film.
- the kappa carrageenan used for this experiment was SKW Satiagel RPT 8/60 Kappa Carrageenan.
- the iota carrageenan used was FMC SD 389 PF Iota Carrageenan.
- FIG. 1 shows the variation in wet strength of the films formed as the surface temperature varied.
- wet film strength is the important strength parameter since the film must have sufficient integrity within 1-4 minutes of casting to survive an open draw and other rigors of capsule production.
- the film thicknesses were lower (probably due to flow on the heated surface).
- the temperature effect was especially dramatic—increasing 5 fold as the surface temperature increased from 53° F. to 150° F.
- the “as-is” film strength, uncorrected for film thickness, increased 4 fold.
- the higher film strength observed when the surface temperature was higher is due to larger, greater numbers and/or more perfect helices.
- the films cool slowly, they have time and mobility near the gelation temperature to form larger and/or more perfect helices.
- a higher percentage of the carrageenan may be involved in helices compared to material that is quench-cooled.
- compositions like that of Example 8 were performed using compositions like that of Example 8, but in which the carrageenan content was reduced by 25% and the total mass solids percentage was increased. These compositions had a mass viscosity and wet film strength similar to that exhibited by the formulation of Example 8.
- the composition and properties of the two soft gels are compared in Table 2 below.
- the two gel masses have similar viscosity/temperature profiles, and gel at similar temperatures. (As mentioned above, a flow rating of 5 is similar to water. A rating of zero indicates that the sample is gelled and there is no flow. A rating of at least 3 is preferred for handing on commercial equipment.)
- Starch-based compositions were prepared containing the same ingredients as in Example 8, except iota carrageenan was used as a complete replacement for kappa carrageenan.
- films formed from such compositions had a slow film formation rate.
- the films formed were soft, weak, and very elastic.
- Tests were then performed using a composition like that of Example 8, except that it included a combination of kappa and iota carrageenan, rather than only kappa carrageenan. This change resulted in stronger films (higher yield stress) than either of the two types of carrageenan alone.
- the strongest films comprised a 50/50 (weight) combination of the two. As much as 50% increase in film strength was measured with the 50/50 blend of kappa/iota compared with the kappa-only films.
- the temperature at which the kappa-only gel mass became a rigid gel was high—about 160° F. for the composition of Example 8 at 44% solids.
- the mass viscosity builds rapidly as its temperature is dropped below 180° F. This could be a problem in manufacturing operations, because the hot mass could set up in a location in manufacturing equipment that is inadvertently underheated. Further, even higher temperatures (190° F. plus) are needed to re-soften the kappa-only gel for capsule sealing.
- kappa carrageenan has a very sharp liquid-gel transition, whereas iota's transition is rather broad.
- FIG. 2 illustrates the effect. Lower gel temperature, and more gradual gelation, should make the films made from kappa/iota mixtures easier to handle and easier to seal.
- Table 3 above illustrates the importance of solids control during handling of these formulations.
- FIG. 3 illustrates the rapid decrease in mass flowability at 170° F. as mass solids increases. The effect is especially pronounced for the kappa-only formulation. Blending iota carrageenan with kappa allows for higher solids while maintaining manageable viscosity.
Abstract
Description
TABLE 1 | ||||||||
Peak | Wet film | |||||||
viscosity | Hot paste | Time | Time | tensile | Pot life | Minimum | Re- | |
Example | during | final visc, | until tack | until dry | strength, | rating @ | flowable | softening |
number | cook, cps | cps, 98° C. | free, sec | hard, sec | g force | 180° F. | temp, ° F. | temp, ° F. |
1 | 18000 | 1700 | <5 | <10 | 75 | 3.5 | 160 | 150 |
2 | 14000 | 2500 | 65 | 100 | * | |||
3 | 13000 | 1150 | 4020 | 5700 | * | |||
4 | 2300 | <5 | <10 | 108 | 0.5 | >180 | >180 | |
5 | 13000 | 2400 | <5 | <10 | 65 | 3.0 | 170 | 150 |
6 | 16000 | 1500 | <5 | <10 | 50 | 4.0 | 160 | 150 |
7 | 11000 | 1300 | <5 | <10 | 75 | 3.5 | 170 | 150 |
*Too weak to test |
TABLE 2 | ||||||||
mass | Flow | Flow | Flow | Flow | Breaking | Breaking | ||
solids, | % | % | rateing | rating | rating | rating | strength, g | strength, g |
% | carrageenan | starch | 180 F | 170 F | 160 F | 150 F | 53 F filming | 105 F filming |
44 | 4.1 | 37 | 4.5 | 4.0 | 2.0 | 0.0 | 57 | 180 |
48 | 5.2 | 42 | 4.0 | 3.0 | 2.0 | 0.0 | — | 78 |
TABLE 3 |
Effect of carrageenan on mass flow properties and gel temperature |
approx min. flow temp, deg F. | approx gel temp, deg F. |
% ds | kappa | kappa/iota | kappa | kappa/ |
42 | 160 | 150 | 150 | 140 |
44 | 165 | 160 | 160 | 150 |
45 | 170 | 160 | 160 | 150 |
46 | 180 | 170 | 160 | 150 |
47 | 185 | 170 | 160 | 150 |
Claims (21)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/584,413 US6375981B1 (en) | 2000-06-01 | 2000-06-01 | Modified starch as a replacement for gelatin in soft gel films and capsules |
PCT/US2001/014888 WO2001091721A2 (en) | 2000-06-01 | 2001-05-09 | Modified starch as a replacement for gelatin in soft gel films and capsules |
AU2001259644A AU2001259644A1 (en) | 2000-06-01 | 2001-05-09 | Modified starch as a replacement for gelatin in soft gel films and capsules |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/584,413 US6375981B1 (en) | 2000-06-01 | 2000-06-01 | Modified starch as a replacement for gelatin in soft gel films and capsules |
Publications (1)
Publication Number | Publication Date |
---|---|
US6375981B1 true US6375981B1 (en) | 2002-04-23 |
Family
ID=24337221
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/584,413 Expired - Lifetime US6375981B1 (en) | 2000-06-01 | 2000-06-01 | Modified starch as a replacement for gelatin in soft gel films and capsules |
Country Status (3)
Country | Link |
---|---|
US (1) | US6375981B1 (en) |
AU (1) | AU2001259644A1 (en) |
WO (1) | WO2001091721A2 (en) |
Cited By (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6528088B1 (en) * | 2000-06-01 | 2003-03-04 | A. E. Staley Manufacturing Co. | Highly flexible starch-based films |
US20030099692A1 (en) * | 2001-11-16 | 2003-05-29 | Susan Lydzinski | Film containing starch |
US20030138482A1 (en) * | 2002-01-18 | 2003-07-24 | Fonkwe Linus G. | Non-gelatin capsule shell formulation |
US20040052839A1 (en) * | 2002-01-18 | 2004-03-18 | Archibald Don A. | Non-gelatin film and method and apparatus for producing same |
US20040063927A1 (en) * | 2000-12-13 | 2004-04-01 | Tsai Albert G. | Production of carrageenan and carrageenan products |
US6730340B1 (en) * | 1999-05-07 | 2004-05-04 | Reg Macquarrie | Edible casing film formulation |
US20040092534A1 (en) * | 2002-07-29 | 2004-05-13 | Yam Nyomi V. | Methods and dosage forms for controlled delivery of paliperidone |
US20040096569A1 (en) * | 2002-11-15 | 2004-05-20 | Barkalow David G. | Edible film products and methods of making same |
US20040111275A1 (en) * | 2002-11-15 | 2004-06-10 | Kroll David B. | Methods for marketing and generating revenue from edible thin films |
US6749880B1 (en) * | 1999-01-29 | 2004-06-15 | Cooperative Verkoop-En Productivevereniging Van Aaardappelmeel En Derivaten Avebe B.A. | Composition based on cross-linked starch and depolymerized starch suitable as gelatine replacement |
US20040137206A1 (en) * | 2003-10-02 | 2004-07-15 | Pettis Rodney L. | Elastomer and polyolefin resin based films and associated methods |
US20040156794A1 (en) * | 2003-02-11 | 2004-08-12 | Barkalow David G. | Bioerodible and bioadhesive confectionery products and methods of making same |
US20040202772A1 (en) * | 2003-04-10 | 2004-10-14 | Matsutani Chemical Industries Co., Ltd. | Method for preparing glucose polymer having ion-exchanging ability and composition containing the same |
WO2004091537A2 (en) * | 2003-04-14 | 2004-10-28 | Fmc Corporation | Process for making gel films |
US20040241294A1 (en) * | 2003-05-31 | 2004-12-02 | Barabolak Roman M. | Edible films including aspartame and methods of making same |
US20050008736A1 (en) * | 2003-05-19 | 2005-01-13 | Egan Philip A. | Non-fluorocarbon high temperature packaging having flexible starch-based film and methods of producing same |
US20050008677A1 (en) * | 2003-04-14 | 2005-01-13 | Fmc Corporation | Delivery system of homogeneous, thermoreversible gel film containing kappa-2 carrageenan |
US20050014852A1 (en) * | 2003-04-14 | 2005-01-20 | Fmc Corporation | Homogeneous, thermoreversible gel containing reduced viscosity carrageenan and products made therefrom |
US20050013847A1 (en) * | 2003-04-14 | 2005-01-20 | Fmc Corporation | Delivery systems of homogeneous, thermoreversible alginate films |
US20050019295A1 (en) * | 2003-04-14 | 2005-01-27 | Fmc Corporation | Homogeneous, thermoreversible low viscosity polymannan gum films and soft capsules made therefrom |
US20050019294A1 (en) * | 2003-04-14 | 2005-01-27 | Fmc Corporation | Homogeneous, thermoreversible alginate films and soft capsules made therefrom |
US20050025968A1 (en) * | 2003-07-28 | 2005-02-03 | Suying Liu | Seamless BB paintball |
EP1508591A1 (en) * | 2003-08-22 | 2005-02-23 | Symrise GmbH & Co. KG | Wrapping material for seamless capsules |
US20050042331A1 (en) * | 2003-08-22 | 2005-02-24 | Billmers Robert L. | Starches for reduced fat in fried foods systems |
US20050048185A1 (en) * | 2003-04-14 | 2005-03-03 | Fmc Corporation | Delivery systems of homogeneous, thermoreversible low viscosity polymannan gum films |
US20050069579A1 (en) * | 2001-11-22 | 2005-03-31 | Ryosei Kamaguchi | Non-gelatinous capsule film compositions and capsules using the same |
US20050186256A1 (en) * | 2004-02-20 | 2005-08-25 | Dihel Deborah L. | Dissolvable film comprising an active ingredient and method of manufacture |
US20050196436A1 (en) * | 2004-03-02 | 2005-09-08 | Arjnarong Chantranukul | Blends of different acyl gellan gums and starch |
US20050196437A1 (en) * | 2004-03-02 | 2005-09-08 | Bednarz Christina A. | Hard capsules |
US20050233048A1 (en) * | 2004-04-20 | 2005-10-20 | Matsutani Chemical Industry Co., Ltd. | Edible film |
US20050277574A1 (en) * | 2004-06-14 | 2005-12-15 | Carl Niedbala | Composition and method for cleaning gelatin encapsulated products comprising comprising a non-volatile silicone/volatile silicone mixture |
US20060011089A1 (en) * | 2004-06-17 | 2006-01-19 | Edward Hensel | Paintball having reduced drag |
US20060053752A1 (en) * | 2003-03-07 | 2006-03-16 | Exopack-Technology, Llc | Method of filling a preformed bag having a reclosable seal |
US20060073175A1 (en) * | 1993-02-22 | 2006-04-06 | American Bioscience, Inc. | Methods and formulations for delivery of pharmacologically active agents |
US20060073292A1 (en) * | 2002-11-08 | 2006-04-06 | Exopack-Technology, Llc | Bag having an improved heat seal closure and associated methods |
US20060079156A1 (en) * | 2003-05-02 | 2006-04-13 | Applied Materials, Inc. | Method for processing a substrate using multiple fluid distributions on a polishing surface |
US20060127657A1 (en) * | 2003-10-02 | 2006-06-15 | Energy Technology Group, Inc. | Elastomer and polyolefin resin based films and associated methods |
US20060134311A1 (en) * | 2002-12-20 | 2006-06-22 | Rolf Mueller | Starch-based rubber-elastic confectionery |
US20060182867A1 (en) * | 2003-03-24 | 2006-08-17 | Clare Hill | Gelled food product with a liquid centre |
US20060289518A1 (en) * | 2005-05-20 | 2006-12-28 | Exopack-Technology, Llc | Microwave cooking package for food products and associated methods |
US20060289519A1 (en) * | 2005-05-20 | 2006-12-28 | Exopack-Technology, Llc | Microwave cooking package for food products and associated methods |
US20070047853A1 (en) * | 2005-08-29 | 2007-03-01 | Exopack-Technology, Llc | Grease-resistant bag having adhesive closure, adhesive closure for bag, and related methods |
US20070047852A1 (en) * | 2005-08-29 | 2007-03-01 | Exopack-Technology, Llc | Grease-resistant pinch-bottom bag, adhesive closure for bag, and related methods |
US20070148380A1 (en) * | 2005-12-27 | 2007-06-28 | Procaps L.P. | Paintball and method of manufacture |
US20070154609A1 (en) * | 2006-01-05 | 2007-07-05 | Yin Li | Extrudable Food Composition |
US20070161942A1 (en) * | 2006-01-06 | 2007-07-12 | Pharmaphil Inc. | Biodegradable tampon applicator and method of making |
US20070184184A1 (en) * | 2003-06-25 | 2007-08-09 | Linda Green | Production of capsule shells and capsules |
US20070281065A1 (en) * | 2006-06-06 | 2007-12-06 | Modliszewski James J | Kappa-2 carrageenan composition and products made therefrom |
US20080000464A1 (en) * | 2003-11-12 | 2008-01-03 | A.J. Acquisition I Llc | Projectile, projectile core, and method of making |
US20080035006A1 (en) * | 2005-02-05 | 2008-02-14 | Ciesiun Paul M | Bioluminescent paintball |
US20080194337A1 (en) * | 2004-10-25 | 2008-08-14 | Edward Hensel | Hunting Game Having Human And Electromechanical Players |
US20090087468A1 (en) * | 2007-03-28 | 2009-04-02 | Serena Stephenson | Semi-Rigid Gel Article For Disinfecting A Surface |
US20090238925A1 (en) * | 2007-12-18 | 2009-09-24 | Shiji Shen | Starch and Amphiphilic Surfactant or Particulate Emulsion for Paper Coating Applications |
US20090324143A1 (en) * | 2005-08-19 | 2009-12-31 | Exopack, Llc. | Bags having composite structures and related methods |
US20100083862A1 (en) * | 2005-02-05 | 2010-04-08 | Ciesiun Paul M | Water based paintall and method for fabricating water based paintballs |
US20100150479A1 (en) * | 2008-12-15 | 2010-06-17 | Exopack, Llc | Multi-layered bags and methods of manufacturing the same |
US20100151009A1 (en) * | 2006-04-12 | 2010-06-17 | Emisphere Technologies Inc. | Formulations for delivering insulin |
US20100158417A1 (en) * | 2008-12-22 | 2010-06-24 | Exopack, Llc | Multi-layered bags and methods of manufacturing the same |
US20110089168A1 (en) * | 2009-10-19 | 2011-04-21 | Exopack, Llc | Microwavable bags for use with liquid oil and related methods |
WO2012018329A1 (en) * | 2010-08-04 | 2012-02-09 | R.P. Scherer Technologies, Llc | Film-forming composition for soft capsules |
WO2012126941A1 (en) * | 2011-03-22 | 2012-09-27 | Nordbloom Ltd | A composition and method |
CN103520133A (en) * | 2013-10-26 | 2014-01-22 | 中山市凯博思淀粉材料科技有限公司 | Preparation method of starch-based soft capsules |
CN103893771A (en) * | 2014-04-21 | 2014-07-02 | 湖南同泰胶囊有限公司 | Film forming composition for producing soft starch material capsule and preparation method of film forming composition |
US20140261506A1 (en) * | 2009-10-09 | 2014-09-18 | Philip Morris Usa Inc. | Tobacco-free pouched product containing flavor beads providing immediate and long lasting flavor release |
CN104059248A (en) * | 2014-06-27 | 2014-09-24 | 江南大学 | Method for improving properties of starch-base edible packaging film by adding hydrophilic colloid |
WO2014209964A1 (en) * | 2013-06-25 | 2014-12-31 | R.P. Scherer Technologies, Llc | Shell-forming compositions for soft capsules and soft capsules |
EP2921276A1 (en) | 2009-03-03 | 2015-09-23 | Innogel AG | Soft capsule capsules based on starch, and method and device for making same |
CN105051129A (en) * | 2013-03-29 | 2015-11-11 | 罗盖特公司 | Film-forming compostions for the film-coating of solid forms |
US9339053B2 (en) | 2013-10-26 | 2016-05-17 | Zhongshan Capsule Starch Material Technology Co., Ltd. | Preparation process of a self-reinforced starch composite used to produce capsules |
US9408858B2 (en) | 2007-04-25 | 2016-08-09 | Opko Renal, Llc | Method for treating secondary hyperparathyroidism in CKD |
KR101675438B1 (en) * | 2015-12-18 | 2016-11-11 | 김문구 | Composition for preparing soft capsule shell |
WO2017021533A1 (en) * | 2015-08-06 | 2017-02-09 | Roquette Freres | Film-forming compositions based on starchy material and articles obtained thereof |
US9861644B2 (en) | 2013-03-15 | 2018-01-09 | Opko Ireland Global Holdings, Ltd. | Stabilized modified release vitamin D formulation and method of administering same |
US9872513B2 (en) | 2013-07-01 | 2018-01-23 | Priscila F. Kimes | Processes in the preparation of coconut meat based compositions and films |
US9895672B2 (en) | 2009-09-10 | 2018-02-20 | DuPont Nutrition USA, Inc. | High strength seamless alginate capsules |
US9943530B2 (en) | 2006-02-03 | 2018-04-17 | Opko Renal, Llc | Treating vitamin D insufficiency and deficiency with 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 |
EP3360544A1 (en) * | 2017-02-08 | 2018-08-15 | Roquette Freres | Film-forming compositions for hard capsule shells and hard capsule shells obtained thereof |
US10184765B1 (en) * | 2015-04-21 | 2019-01-22 | Briana Gardell | Throwable paint balls and method of manufacture |
US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
US10302660B2 (en) | 2008-04-02 | 2019-05-28 | Opko Renal, Llc | Methods useful for vitamin D deficiency and related disorders |
CN111116949A (en) * | 2018-10-31 | 2020-05-08 | 齐鲁工业大学 | Preparation method of double-enzyme modified composite edible film with slow digestion characteristic |
US10668089B2 (en) | 2006-06-21 | 2020-06-02 | Opko Ireland Global Holdings, Ltd. | Method of treating and preventing secondary hyperparathyroidism |
CN113121889A (en) * | 2019-12-30 | 2021-07-16 | 仙乐健康科技股份有限公司 | Starch film-forming composition and application thereof in plant soft capsules |
US11173168B2 (en) | 2016-03-28 | 2021-11-16 | Eirgen Pharma Ltd. | Methods of treating vitamin D insufficiency in chronic kidney disease |
WO2022226217A1 (en) | 2021-04-22 | 2022-10-27 | Civi Biopharma, Inc. | Oral delivery of oligonucleotides |
US11560439B2 (en) * | 2020-04-24 | 2023-01-24 | Hunan Er-Kang Pharmaceutical Co., Ltd. | Hydroxypropyl starch for preparing empty capsules and hydroxypropyl starch-based soft capsules |
US11672809B2 (en) | 2010-03-29 | 2023-06-13 | Eirgen Pharma Ltd. | Methods and compositions for reducing parathyroid levels |
US11752158B2 (en) | 2007-04-25 | 2023-09-12 | Eirgen Pharma Ltd. | Method of treating vitamin D insufficiency and deficiency |
US11801253B2 (en) | 2007-04-25 | 2023-10-31 | Opko Renal, Llc | Method of safely and effectively treating and preventing secondary hyperparathyroidism in chronic kidney disease |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1292639B1 (en) * | 2000-06-01 | 2009-03-11 | A.E. Staley Manufacturing Company | Highly flexible starch-based films |
AU4061702A (en) * | 2001-05-15 | 2003-04-03 | Mcneil-Ppc, Inc. | Dip coating compositions containing starch or dextrin |
US20030070584A1 (en) | 2001-05-15 | 2003-04-17 | Cynthia Gulian | Dip coating compositions containing cellulose ethers |
US8309118B2 (en) | 2001-09-28 | 2012-11-13 | Mcneil-Ppc, Inc. | Film forming compositions containing sucralose |
US20110033542A1 (en) | 2009-08-07 | 2011-02-10 | Monosol Rx, Llc | Sublingual and buccal film compositions |
US11207805B2 (en) | 2001-10-12 | 2021-12-28 | Aquestive Therapeutics, Inc. | Process for manufacturing a resulting pharmaceutical film |
US8663687B2 (en) | 2001-10-12 | 2014-03-04 | Monosol Rx, Llc | Film compositions for delivery of actives |
US20070281003A1 (en) | 2001-10-12 | 2007-12-06 | Fuisz Richard C | Polymer-Based Films and Drug Delivery Systems Made Therefrom |
US20190328679A1 (en) | 2001-10-12 | 2019-10-31 | Aquestive Therapeutics, Inc. | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
US8765167B2 (en) | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
US8900497B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for making a film having a substantially uniform distribution of components |
US7666337B2 (en) | 2002-04-11 | 2010-02-23 | Monosol Rx, Llc | Polyethylene oxide-based films and drug delivery systems made therefrom |
US8900498B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
US7425292B2 (en) | 2001-10-12 | 2008-09-16 | Monosol Rx, Llc | Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom |
US8603514B2 (en) | 2002-04-11 | 2013-12-10 | Monosol Rx, Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
US10285910B2 (en) | 2001-10-12 | 2019-05-14 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
US7357891B2 (en) | 2001-10-12 | 2008-04-15 | Monosol Rx, Llc | Process for making an ingestible film |
ES2735512T3 (en) * | 2001-10-12 | 2019-12-19 | Aquestive Therapeutics Inc | Thin film with uniform non-self-aggregating heterogeneity, process for its production and drug delivery systems made from it |
US20030198682A1 (en) * | 2002-02-12 | 2003-10-23 | Gruber James V. | Composition and method for protecting labile active components during high temperature drying |
US8017150B2 (en) | 2002-04-11 | 2011-09-13 | Monosol Rx, Llc | Polyethylene oxide-based films and drug delivery systems made therefrom |
WO2004066986A1 (en) * | 2003-01-30 | 2004-08-12 | Monosolrx Llc | Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom |
EP2716284A3 (en) * | 2003-05-28 | 2014-11-05 | MonoSol RX LLC | Polyethylene oxide-based films and drug delivery systems made herefrom |
US20070034827A1 (en) * | 2005-12-02 | 2007-02-15 | Zhixin Li | Blends of gelling and non-gelling starches with gellan gums and plasticizer |
US7569529B2 (en) | 2005-09-07 | 2009-08-04 | The Procter & Gamble Company | Method of using fabric care compositions to achieve a synergistic odor benefit |
US8574624B2 (en) | 2006-11-17 | 2013-11-05 | Corn Products Development, Inc. | Highly inhibited starch fillers for films and capsules |
AU2009203054B2 (en) * | 2008-04-02 | 2013-09-05 | Dsm Ip Assets B.V. | Gum confections |
JP4797211B2 (en) * | 2009-02-05 | 2011-10-19 | キャタレント・ジャパン株式会社 | Film forming composition for soft capsule |
EP2243381A1 (en) * | 2009-04-24 | 2010-10-27 | Mars, Incorporated | Edible composition |
US8475832B2 (en) | 2009-08-07 | 2013-07-02 | Rb Pharmaceuticals Limited | Sublingual and buccal film compositions |
EP2579844B1 (en) | 2010-06-10 | 2016-02-24 | Midatech Ltd. | Nanoparticle film delivery systems |
MX2013000041A (en) * | 2010-06-29 | 2013-06-05 | Tate & Lyle Ingredients | Hydroxypropyl substituted starches as source of soluble fiber. |
US9149959B2 (en) | 2010-10-22 | 2015-10-06 | Monosol Rx, Llc | Manufacturing of small film strips |
CN102167845A (en) * | 2010-12-09 | 2011-08-31 | 楼仲平 | Method for preparing degradable biomass material and straw |
BR112015028255B1 (en) * | 2013-05-21 | 2021-06-22 | Cargill, Incorporated | AQUEOUS COMPOSITION, METHOD FOR THE PRODUCTION OF AN AQUEOUS COMPOSITION, BINDING COMPOSITION, PAPER COATING COMPOSITION AND PAPER COATING COMPOSITION |
CN104257874A (en) * | 2014-09-28 | 2015-01-07 | 通化市佳俊生物电子有限公司 | Patch for treating hyperplasia of mammary glands and medical application of potatoes |
CN105166885A (en) * | 2015-08-07 | 2015-12-23 | 江南大学 | Conjugated linoleic acid embedded microcapsule preparation method |
CN105694118A (en) * | 2016-01-29 | 2016-06-22 | 上海盈美机电工程有限公司 | Novel lightly crosslinked-starch succinate-based empty capsule and preparation method thereof |
CN105646951B (en) * | 2016-03-03 | 2018-11-20 | 武汉市九合生物技术有限公司 | The preparation method of functional solvable edible composite membrane |
US11273131B2 (en) | 2016-05-05 | 2022-03-15 | Aquestive Therapeutics, Inc. | Pharmaceutical compositions with enhanced permeation |
WO2017192921A1 (en) | 2016-05-05 | 2017-11-09 | Monosol Rx, Llc | Enhanced delivery epinephrine compositions |
EP3758684A1 (en) * | 2018-03-02 | 2021-01-06 | Captek Softgel International, Inc | Soft gel compositions and capsules made from the same |
CN114306272A (en) * | 2019-06-12 | 2022-04-12 | 江苏艾兰得营养品有限公司 | Plant soft capsule and preparation method and application thereof |
WO2024064875A1 (en) * | 2022-09-23 | 2024-03-28 | Cargill, Incorporated | Natural based carbomer replacement |
Citations (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3499962A (en) | 1967-08-24 | 1970-03-10 | Nat Starch Chem Corp | Encapsulation of water insoluble materials |
US3865603A (en) | 1972-07-17 | 1975-02-11 | Nat Starch Chem Corp | Modified starch-extended gelatin compositions |
US3956173A (en) | 1974-07-05 | 1976-05-11 | Hercules Incorporated | Preparation of gels based on carrageenan |
US4009291A (en) * | 1974-03-25 | 1977-02-22 | General Foods Corporation | Cold water soluble stable bulked starch |
US4026986A (en) | 1975-05-22 | 1977-05-31 | The Dow Chemical Company | Capsule shell |
US4795642A (en) | 1986-05-01 | 1989-01-03 | Pharmacaps, Inc. | Gelatin-encapsulated controlled-release composition |
US4804542A (en) | 1985-08-20 | 1989-02-14 | R. P. Scherer Gmbh | Gelatin capsules and method of preparing same |
US4935243A (en) | 1988-12-19 | 1990-06-19 | Pharmacaps, Inc. | Chewable, edible soft gelatin capsule |
EP0400484A1 (en) | 1989-05-23 | 1990-12-05 | Mitsubishi Rayon Co., Ltd | Edible film and method of making same |
EP0409781A2 (en) | 1989-07-18 | 1991-01-23 | Warner-Lambert Company | Polymer base blend compositions containing destructurized starch |
EP0471558A2 (en) | 1990-08-14 | 1992-02-19 | Unilever Plc | Moisture barrier and its preparation |
EP0547551A1 (en) | 1991-12-16 | 1993-06-23 | National Starch and Chemical Investment Holding Corporation | Edible films |
US5334640A (en) | 1992-04-08 | 1994-08-02 | Clover Consolidated, Ltd. | Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods |
US5342626A (en) | 1993-04-27 | 1994-08-30 | Merck & Co., Inc. | Composition and process for gelatin-free soft capsules |
WO1994025493A1 (en) | 1993-04-23 | 1994-11-10 | The United States Of America, As Represented By The Secretary, U.S. Department Of Agriculture | Biodegradable films fabricated from mixtures of pectin/starch/plasticizers |
EP0633896A1 (en) | 1992-03-31 | 1995-01-18 | National Starch and Chemical Investment Holding Corporation | Esterified starch composition |
US5393054A (en) | 1994-03-09 | 1995-02-28 | Zap Paintball Corporation | Paint ball |
US5484598A (en) | 1992-08-18 | 1996-01-16 | R.P. Scherer Corporation | Soft gelatin medicament capsules with gripping construction |
US5554385A (en) | 1990-11-28 | 1996-09-10 | R. P. Scherer Corporation | High amylose starch substituted gelatin capsules |
US5726008A (en) | 1996-09-18 | 1998-03-10 | Eastman Kodak Company | Photographic elements with improved vehicles |
US5756123A (en) | 1994-12-01 | 1998-05-26 | Japan Elanco Co., Ltd. | Capsule shell |
US5817323A (en) | 1993-06-28 | 1998-10-06 | R.P. Scherer Corporation | Soft gelatin capsule shell compositions |
US5932639A (en) | 1996-05-06 | 1999-08-03 | National Starch And Chemical Investment Holding Corporation | Maltodextrin-based adhesives |
US5976586A (en) | 1997-03-10 | 1999-11-02 | Lawrence Foods | Glaze composition with vegetable gums |
WO2000010538A1 (en) | 1998-08-25 | 2000-03-02 | Banner Pharmacaps, Inc. | Non-gelatin substitutes for oral delivery capsules, their composition and process of manufacture |
WO2001003677A1 (en) | 1999-07-07 | 2001-01-18 | R.P. Scherer Technologies, Inc. | Film forming compositions comprising modified starches and iota-carrageenan and methods for manufacturing soft capsules using same |
US6210709B1 (en) | 1999-03-24 | 2001-04-03 | Elementis Specialties, Inc. | Flexible gelatin free encapsulation material useful for pharmaceuticals, paint balls and other formulations |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH054914A (en) * | 1991-06-27 | 1993-01-14 | Asahi Chem Ind Co Ltd | Capsule improved in adhesion |
JP2000116339A (en) * | 1998-08-13 | 2000-04-25 | Itoo Kaigai Jigyo Kk | Production of edible film |
FR2783832A1 (en) * | 1998-09-30 | 2000-03-31 | Warner Lambert Co | Compositions for manufacture of pharmaceutical capsules comprise hydroxy propylated starch and hydrocolloid plus cation hardening system |
ATE291420T1 (en) * | 1999-11-19 | 2005-04-15 | Swiss Caps Rechte & Lizenzen | METHOD FOR PRODUCING A MOLDED BODY CONTAINING STARCH, HOMOGENIZED MASS CONTAINING STARCH AND DEVICE FOR PRODUCING A SOFT CAPSULE |
-
2000
- 2000-06-01 US US09/584,413 patent/US6375981B1/en not_active Expired - Lifetime
-
2001
- 2001-05-09 AU AU2001259644A patent/AU2001259644A1/en not_active Abandoned
- 2001-05-09 WO PCT/US2001/014888 patent/WO2001091721A2/en active Application Filing
Patent Citations (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3499962A (en) | 1967-08-24 | 1970-03-10 | Nat Starch Chem Corp | Encapsulation of water insoluble materials |
US3865603A (en) | 1972-07-17 | 1975-02-11 | Nat Starch Chem Corp | Modified starch-extended gelatin compositions |
US4009291A (en) * | 1974-03-25 | 1977-02-22 | General Foods Corporation | Cold water soluble stable bulked starch |
US3956173A (en) | 1974-07-05 | 1976-05-11 | Hercules Incorporated | Preparation of gels based on carrageenan |
US4026986A (en) | 1975-05-22 | 1977-05-31 | The Dow Chemical Company | Capsule shell |
US4804542A (en) | 1985-08-20 | 1989-02-14 | R. P. Scherer Gmbh | Gelatin capsules and method of preparing same |
US4795642A (en) | 1986-05-01 | 1989-01-03 | Pharmacaps, Inc. | Gelatin-encapsulated controlled-release composition |
US4935243A (en) | 1988-12-19 | 1990-06-19 | Pharmacaps, Inc. | Chewable, edible soft gelatin capsule |
EP0400484A1 (en) | 1989-05-23 | 1990-12-05 | Mitsubishi Rayon Co., Ltd | Edible film and method of making same |
US5089307A (en) | 1989-05-23 | 1992-02-18 | Mitsubishi Rayon Co., Ltd. | Edible film and method of making same |
US5620757A (en) | 1989-05-23 | 1997-04-15 | Mitsubishi Rayon Co., Ltd. | Edible film and method of making same |
EP0409781A2 (en) | 1989-07-18 | 1991-01-23 | Warner-Lambert Company | Polymer base blend compositions containing destructurized starch |
EP0471558A2 (en) | 1990-08-14 | 1992-02-19 | Unilever Plc | Moisture barrier and its preparation |
US5554385A (en) | 1990-11-28 | 1996-09-10 | R. P. Scherer Corporation | High amylose starch substituted gelatin capsules |
EP0547551A1 (en) | 1991-12-16 | 1993-06-23 | National Starch and Chemical Investment Holding Corporation | Edible films |
EP0633896A1 (en) | 1992-03-31 | 1995-01-18 | National Starch and Chemical Investment Holding Corporation | Esterified starch composition |
US5334640A (en) | 1992-04-08 | 1994-08-02 | Clover Consolidated, Ltd. | Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods |
US5550178A (en) | 1992-04-08 | 1996-08-27 | Vivorx, Inc. | Process for encapsulating biologics using crosslinkable biocompatible encapsulation system |
US5484598A (en) | 1992-08-18 | 1996-01-16 | R.P. Scherer Corporation | Soft gelatin medicament capsules with gripping construction |
US5451673A (en) | 1993-04-23 | 1995-09-19 | The United States Of America As Represented By The Secretary Of Agriculture | Films fabricated from mixtures of pectin and starch |
WO1994025493A1 (en) | 1993-04-23 | 1994-11-10 | The United States Of America, As Represented By The Secretary, U.S. Department Of Agriculture | Biodegradable films fabricated from mixtures of pectin/starch/plasticizers |
US5342626A (en) | 1993-04-27 | 1994-08-30 | Merck & Co., Inc. | Composition and process for gelatin-free soft capsules |
US5817323A (en) | 1993-06-28 | 1998-10-06 | R.P. Scherer Corporation | Soft gelatin capsule shell compositions |
US5393054A (en) | 1994-03-09 | 1995-02-28 | Zap Paintball Corporation | Paint ball |
US5756123A (en) | 1994-12-01 | 1998-05-26 | Japan Elanco Co., Ltd. | Capsule shell |
US5932639A (en) | 1996-05-06 | 1999-08-03 | National Starch And Chemical Investment Holding Corporation | Maltodextrin-based adhesives |
US5726008A (en) | 1996-09-18 | 1998-03-10 | Eastman Kodak Company | Photographic elements with improved vehicles |
US5976586A (en) | 1997-03-10 | 1999-11-02 | Lawrence Foods | Glaze composition with vegetable gums |
WO2000010538A1 (en) | 1998-08-25 | 2000-03-02 | Banner Pharmacaps, Inc. | Non-gelatin substitutes for oral delivery capsules, their composition and process of manufacture |
US6210709B1 (en) | 1999-03-24 | 2001-04-03 | Elementis Specialties, Inc. | Flexible gelatin free encapsulation material useful for pharmaceuticals, paint balls and other formulations |
WO2001003677A1 (en) | 1999-07-07 | 2001-01-18 | R.P. Scherer Technologies, Inc. | Film forming compositions comprising modified starches and iota-carrageenan and methods for manufacturing soft capsules using same |
Non-Patent Citations (26)
Title |
---|
"The Birth of a Paintball," R.P. Scherer Paintballs-How Paintballs are. . . , pp. 1-2 (1998). |
Arvanitoyannis et al., "Edible Films Made from Hydroxypropyl Starch and Gelatin and Plasticized by Polyols and Water," Carbohydrate Polymers 36:105-119 (1998). |
BeMiller et al., "Carbohydrates," Food Chemistry, pp. 205-223 (No Date). |
Bergthaller et al., "Potato Starch Technology," Starch/Stärke 51:235-242 (1999). |
Derwent Abstract EP 273823 A. |
Derwent Abstract EP 400484 A. |
Derwent Abstract EP 471558 A. |
Derwent Abstract JP 5004914 A. |
Derwent Abstract JP 5148388 A. |
Derwent Abstract JP 60037966 A. |
Derwent Abstract JP 61009258 A. |
Derwent Abstract JP 63170310 A. |
Derwent Abstract JP 72023384 B. |
Derwent Abstract WO 9200731 A. |
Derwent Abstract WO 9206672 A. |
Derwent Abstract WO 9218014 A. |
Derwent Abstract WO 9304670 A. |
Derwent Abstract WO 9923118 A1. |
Hermansson et al., "Effects of Potassium, Sodium and Calcium on the Microstructure and Rheological Behaviour of Kappa-Carrageenan Gels," Carbohydrate Polymers 16:297-320 (1991). |
Kester et al., "Edible Films and Coatings: A Review," Food Technology 40:47-59 (1986). |
Krochta et al., "Edible and Biodegradable Polymer Films: Challenges and Opportunities," Food Technology 51:61-74 (1997). |
Lourdin et al., "Influence of Amylose Content on Starch Films and Foams," Carbohydrate Polymers 27:261-270 (1995). |
Picullel, "Gelling Carrageenans,"Food Polysaccharides and Their Applications, pp. 205, 210-212, 233-234 (1995). |
Rochas et al., "Relation Between the Molecular Structure and Mechanical Properties of Carrageenan Gels," Carbohydrate Polymers 10:115-127 (1989). |
Shih, "Effects of Additives on the Development of Edible Films," Chemistry of Novel Foods, Chapter 14, 1995 International Chemical Congress of Pacific Basin Societies, Honolulu, Hawaii (Dec. 17-22, 1995). |
U.S. Patent Application Ser. No. 09/585,846, filed Jun. 1, 2000. |
Cited By (163)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060073175A1 (en) * | 1993-02-22 | 2006-04-06 | American Bioscience, Inc. | Methods and formulations for delivery of pharmacologically active agents |
US6749880B1 (en) * | 1999-01-29 | 2004-06-15 | Cooperative Verkoop-En Productivevereniging Van Aaardappelmeel En Derivaten Avebe B.A. | Composition based on cross-linked starch and depolymerized starch suitable as gelatine replacement |
US6730340B1 (en) * | 1999-05-07 | 2004-05-04 | Reg Macquarrie | Edible casing film formulation |
US6528088B1 (en) * | 2000-06-01 | 2003-03-04 | A. E. Staley Manufacturing Co. | Highly flexible starch-based films |
US6649188B2 (en) * | 2000-06-01 | 2003-11-18 | A. E. Staley Manufacturing Co. | Highly flexible starch-based films |
US20040063927A1 (en) * | 2000-12-13 | 2004-04-01 | Tsai Albert G. | Production of carrageenan and carrageenan products |
US7772211B2 (en) | 2000-12-13 | 2010-08-10 | Fmc Corporation | Production of carrageenan and carrageenan products |
US20070112184A1 (en) * | 2000-12-13 | 2007-05-17 | Tsai Albert G | Production of carrageenan and carrageenan products |
US7189843B2 (en) | 2000-12-13 | 2007-03-13 | Fmc Corporation | Production of carrageenan and carrageenan products |
US20030099692A1 (en) * | 2001-11-16 | 2003-05-29 | Susan Lydzinski | Film containing starch |
US7255921B2 (en) * | 2001-11-22 | 2007-08-14 | Morishita Jintan Co., Ltd. | Non-gelatinous capsule shell composition and a capsule formed from the same |
US20050069579A1 (en) * | 2001-11-22 | 2005-03-31 | Ryosei Kamaguchi | Non-gelatinous capsule film compositions and capsules using the same |
US20040052839A1 (en) * | 2002-01-18 | 2004-03-18 | Archibald Don A. | Non-gelatin film and method and apparatus for producing same |
US7887838B2 (en) | 2002-01-18 | 2011-02-15 | Banner Pharmacaps, Inc. | Non-gelatin film and method and apparatus for producing same |
US20060029660A1 (en) * | 2002-01-18 | 2006-02-09 | Fonkwe Linus G | Non-gelatin capsule shell formulation |
US6949256B2 (en) | 2002-01-18 | 2005-09-27 | Banner Pharmacaps, Inc. | Non-gelatin capsule shell formulation |
US20030138482A1 (en) * | 2002-01-18 | 2003-07-24 | Fonkwe Linus G. | Non-gelatin capsule shell formulation |
US20040092534A1 (en) * | 2002-07-29 | 2004-05-13 | Yam Nyomi V. | Methods and dosage forms for controlled delivery of paliperidone |
US7544403B2 (en) | 2002-11-08 | 2009-06-09 | Exopack, Llc | Bag having an improved heat seal closure and associated methods |
US20060073292A1 (en) * | 2002-11-08 | 2006-04-06 | Exopack-Technology, Llc | Bag having an improved heat seal closure and associated methods |
US20040096569A1 (en) * | 2002-11-15 | 2004-05-20 | Barkalow David G. | Edible film products and methods of making same |
US20040111275A1 (en) * | 2002-11-15 | 2004-06-10 | Kroll David B. | Methods for marketing and generating revenue from edible thin films |
US20060134311A1 (en) * | 2002-12-20 | 2006-06-22 | Rolf Mueller | Starch-based rubber-elastic confectionery |
US20040156794A1 (en) * | 2003-02-11 | 2004-08-12 | Barkalow David G. | Bioerodible and bioadhesive confectionery products and methods of making same |
US20060053746A1 (en) * | 2003-03-07 | 2006-03-16 | Exopack-Technology, Llc | Method of forming a bag having a reclosable seal |
US7549269B2 (en) | 2003-03-07 | 2009-06-23 | Exopack Llc | Method of forming a bag having a reclosable seal |
US20060053752A1 (en) * | 2003-03-07 | 2006-03-16 | Exopack-Technology, Llc | Method of filling a preformed bag having a reclosable seal |
US20060182867A1 (en) * | 2003-03-24 | 2006-08-17 | Clare Hill | Gelled food product with a liquid centre |
AU2010257249B2 (en) * | 2003-03-24 | 2011-11-03 | Nestec S.A. | Gelled food product with a liquid centre |
CN100452981C (en) * | 2003-03-24 | 2009-01-21 | 雀巢技术公司 | Gelled food product with a liquid centre |
US20040202772A1 (en) * | 2003-04-10 | 2004-10-14 | Matsutani Chemical Industries Co., Ltd. | Method for preparing glucose polymer having ion-exchanging ability and composition containing the same |
US20050019294A1 (en) * | 2003-04-14 | 2005-01-27 | Fmc Corporation | Homogeneous, thermoreversible alginate films and soft capsules made therefrom |
US20050008677A1 (en) * | 2003-04-14 | 2005-01-13 | Fmc Corporation | Delivery system of homogeneous, thermoreversible gel film containing kappa-2 carrageenan |
JP2007528357A (en) * | 2003-04-14 | 2007-10-11 | エフ エム シー コーポレーション | Method for producing a gel film |
US20080089934A1 (en) * | 2003-04-14 | 2008-04-17 | Fmc Corporation | Process for making gel films |
WO2004091537A2 (en) * | 2003-04-14 | 2004-10-28 | Fmc Corporation | Process for making gel films |
US7816341B2 (en) | 2003-04-14 | 2010-10-19 | Fmc Corporation | Homogeneous, thermoreversible gel containing reduced viscosity carrageenan and products made therefrom |
US7807194B2 (en) | 2003-04-14 | 2010-10-05 | Fmc Corporation | Homogeneous, thermoreversible gel film containing kappa-2 carrageenan and soft capsules made therefrom |
US20050019374A1 (en) * | 2003-04-14 | 2005-01-27 | Fmc Corporation | Homogeneous, thermoreversible gel film containing kappa-2 carragenan and soft capsules made therefrom |
WO2004091537A3 (en) * | 2003-04-14 | 2005-05-06 | Fmc Corp | Process for making gel films |
US20050013847A1 (en) * | 2003-04-14 | 2005-01-20 | Fmc Corporation | Delivery systems of homogeneous, thermoreversible alginate films |
US20050084516A1 (en) * | 2003-04-14 | 2005-04-21 | Fmc Corporation | Process for making gel films |
US20050014852A1 (en) * | 2003-04-14 | 2005-01-20 | Fmc Corporation | Homogeneous, thermoreversible gel containing reduced viscosity carrageenan and products made therefrom |
US20050048185A1 (en) * | 2003-04-14 | 2005-03-03 | Fmc Corporation | Delivery systems of homogeneous, thermoreversible low viscosity polymannan gum films |
US20050019295A1 (en) * | 2003-04-14 | 2005-01-27 | Fmc Corporation | Homogeneous, thermoreversible low viscosity polymannan gum films and soft capsules made therefrom |
US20060079156A1 (en) * | 2003-05-02 | 2006-04-13 | Applied Materials, Inc. | Method for processing a substrate using multiple fluid distributions on a polishing surface |
US20050008736A1 (en) * | 2003-05-19 | 2005-01-13 | Egan Philip A. | Non-fluorocarbon high temperature packaging having flexible starch-based film and methods of producing same |
US20040241294A1 (en) * | 2003-05-31 | 2004-12-02 | Barabolak Roman M. | Edible films including aspartame and methods of making same |
US20070184184A1 (en) * | 2003-06-25 | 2007-08-09 | Linda Green | Production of capsule shells and capsules |
US20050025968A1 (en) * | 2003-07-28 | 2005-02-03 | Suying Liu | Seamless BB paintball |
US20060205546A1 (en) * | 2003-07-28 | 2006-09-14 | Suying Liu | Seamless BB paintball |
US7134978B2 (en) * | 2003-07-28 | 2006-11-14 | Sagittarius Life Science Corporation | Seamless BB paintball |
US20050042331A1 (en) * | 2003-08-22 | 2005-02-24 | Billmers Robert L. | Starches for reduced fat in fried foods systems |
WO2005021635A1 (en) * | 2003-08-22 | 2005-03-10 | Symrise Gmbh & Co. Kg | Covering material for seamless capsules |
EP1508591A1 (en) * | 2003-08-22 | 2005-02-23 | Symrise GmbH & Co. KG | Wrapping material for seamless capsules |
US7582341B2 (en) | 2003-10-02 | 2009-09-01 | Exopack Technology Llc | Elastomer and polyolefin resin based films and associated methods |
US7083838B2 (en) | 2003-10-02 | 2006-08-01 | Exopack, L.L.C. | Elastomer and polyolefin resin based films and associated methods |
US20040137206A1 (en) * | 2003-10-02 | 2004-07-15 | Pettis Rodney L. | Elastomer and polyolefin resin based films and associated methods |
US20060127657A1 (en) * | 2003-10-02 | 2006-06-15 | Energy Technology Group, Inc. | Elastomer and polyolefin resin based films and associated methods |
US7934454B2 (en) | 2003-11-12 | 2011-05-03 | Kee Action Sports I Llc | Projectile, projectile core, and method of making |
US20080000464A1 (en) * | 2003-11-12 | 2008-01-03 | A.J. Acquisition I Llc | Projectile, projectile core, and method of making |
US20050186256A1 (en) * | 2004-02-20 | 2005-08-25 | Dihel Deborah L. | Dissolvable film comprising an active ingredient and method of manufacture |
US7494667B2 (en) * | 2004-03-02 | 2009-02-24 | Brunob Ii B.V. | Blends of different acyl gellan gums and starch |
US20050196437A1 (en) * | 2004-03-02 | 2005-09-08 | Bednarz Christina A. | Hard capsules |
US20050196436A1 (en) * | 2004-03-02 | 2005-09-08 | Arjnarong Chantranukul | Blends of different acyl gellan gums and starch |
EP1589067A1 (en) * | 2004-04-20 | 2005-10-26 | Matsutani Chemical Industry Co., Ltd. | Edible film |
US20050233048A1 (en) * | 2004-04-20 | 2005-10-20 | Matsutani Chemical Industry Co., Ltd. | Edible film |
US6998374B2 (en) | 2004-06-14 | 2006-02-14 | Carl Niedbala | Composition and method for cleaning gelatin encapsulated products comprising a non-volatile silicone/volatile silicone mixture |
US20050277574A1 (en) * | 2004-06-14 | 2005-12-15 | Carl Niedbala | Composition and method for cleaning gelatin encapsulated products comprising comprising a non-volatile silicone/volatile silicone mixture |
US20060011089A1 (en) * | 2004-06-17 | 2006-01-19 | Edward Hensel | Paintball having reduced drag |
US20080194337A1 (en) * | 2004-10-25 | 2008-08-14 | Edward Hensel | Hunting Game Having Human And Electromechanical Players |
US20080035006A1 (en) * | 2005-02-05 | 2008-02-14 | Ciesiun Paul M | Bioluminescent paintball |
US7905181B2 (en) | 2005-02-05 | 2011-03-15 | Ciesiun Paul M | Bioluminescent paintball |
US8479656B2 (en) | 2005-02-05 | 2013-07-09 | Hydro-Caps, Llc | Water based paintball and method for fabricating water based paintballs |
US20100083862A1 (en) * | 2005-02-05 | 2010-04-08 | Ciesiun Paul M | Water based paintall and method for fabricating water based paintballs |
US20060289519A1 (en) * | 2005-05-20 | 2006-12-28 | Exopack-Technology, Llc | Microwave cooking package for food products and associated methods |
US20060289518A1 (en) * | 2005-05-20 | 2006-12-28 | Exopack-Technology, Llc | Microwave cooking package for food products and associated methods |
US20090324143A1 (en) * | 2005-08-19 | 2009-12-31 | Exopack, Llc. | Bags having composite structures and related methods |
US20070047852A1 (en) * | 2005-08-29 | 2007-03-01 | Exopack-Technology, Llc | Grease-resistant pinch-bottom bag, adhesive closure for bag, and related methods |
US20070047853A1 (en) * | 2005-08-29 | 2007-03-01 | Exopack-Technology, Llc | Grease-resistant bag having adhesive closure, adhesive closure for bag, and related methods |
US20070148380A1 (en) * | 2005-12-27 | 2007-06-28 | Procaps L.P. | Paintball and method of manufacture |
US20070154609A1 (en) * | 2006-01-05 | 2007-07-05 | Yin Li | Extrudable Food Composition |
US20070161942A1 (en) * | 2006-01-06 | 2007-07-12 | Pharmaphil Inc. | Biodegradable tampon applicator and method of making |
US9943530B2 (en) | 2006-02-03 | 2018-04-17 | Opko Renal, Llc | Treating vitamin D insufficiency and deficiency with 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 |
US10213442B2 (en) | 2006-02-03 | 2019-02-26 | Opko Renal, Llc | Treating vitamin D insufficiency and deficiency with 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 |
US11007204B2 (en) | 2006-02-03 | 2021-05-18 | Opko Renal, Llc | Treating vitamin D insufficiency and deficiency with 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 |
US11911398B2 (en) | 2006-02-03 | 2024-02-27 | Opko Renal, Llc | Treating Vitamin D insufficiency and deficiency with 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 |
US20100151009A1 (en) * | 2006-04-12 | 2010-06-17 | Emisphere Technologies Inc. | Formulations for delivering insulin |
US8927015B2 (en) | 2006-04-12 | 2015-01-06 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
US20100272866A1 (en) * | 2006-06-06 | 2010-10-28 | Fmc Corporation | Kappa-2 Carrageenan Composition and Products Made Therefrom |
US20070281065A1 (en) * | 2006-06-06 | 2007-12-06 | Modliszewski James J | Kappa-2 carrageenan composition and products made therefrom |
US10668089B2 (en) | 2006-06-21 | 2020-06-02 | Opko Ireland Global Holdings, Ltd. | Method of treating and preventing secondary hyperparathyroidism |
US20090087468A1 (en) * | 2007-03-28 | 2009-04-02 | Serena Stephenson | Semi-Rigid Gel Article For Disinfecting A Surface |
US9408858B2 (en) | 2007-04-25 | 2016-08-09 | Opko Renal, Llc | Method for treating secondary hyperparathyroidism in CKD |
US11154509B2 (en) | 2007-04-25 | 2021-10-26 | Eirgen Pharma Ltd. | Methods for controlled release oral dosage of a vitamin D compound |
US9925147B2 (en) | 2007-04-25 | 2018-03-27 | Opko Renal, Llc | Method for treating secondary hyperparathyroidism in CKD |
US9918940B2 (en) | 2007-04-25 | 2018-03-20 | Opko Renal, Llc | Methods for controlled release oral dosage of a vitamin D compound |
US9498486B1 (en) | 2007-04-25 | 2016-11-22 | Opko Renal, Llc | Method for controlled release oral dosage of a vitamin D compound |
US11752158B2 (en) | 2007-04-25 | 2023-09-12 | Eirgen Pharma Ltd. | Method of treating vitamin D insufficiency and deficiency |
US11801253B2 (en) | 2007-04-25 | 2023-10-31 | Opko Renal, Llc | Method of safely and effectively treating and preventing secondary hyperparathyroidism in chronic kidney disease |
US20090238925A1 (en) * | 2007-12-18 | 2009-09-24 | Shiji Shen | Starch and Amphiphilic Surfactant or Particulate Emulsion for Paper Coating Applications |
US10302660B2 (en) | 2008-04-02 | 2019-05-28 | Opko Renal, Llc | Methods useful for vitamin D deficiency and related disorders |
US9056697B2 (en) | 2008-12-15 | 2015-06-16 | Exopack, Llc | Multi-layered bags and methods of manufacturing the same |
US20100150479A1 (en) * | 2008-12-15 | 2010-06-17 | Exopack, Llc | Multi-layered bags and methods of manufacturing the same |
US20100158417A1 (en) * | 2008-12-22 | 2010-06-24 | Exopack, Llc | Multi-layered bags and methods of manufacturing the same |
US8282539B2 (en) | 2008-12-22 | 2012-10-09 | Exopack, Llc | Multi-layered bags and methods of manufacturing the same |
US9486415B2 (en) | 2009-03-03 | 2016-11-08 | Innogel Ag | Starch foils and/or films and a method and use of a device for the production thereof |
EP2921276A1 (en) | 2009-03-03 | 2015-09-23 | Innogel AG | Soft capsule capsules based on starch, and method and device for making same |
US11160760B2 (en) | 2009-03-03 | 2021-11-02 | Innogel Ag | Soft capsule based on starch and a method and device for the production thereof |
US9339474B2 (en) | 2009-03-03 | 2016-05-17 | Innogel Ag | Soft capsule based on starch and a method and device for the production thereof |
US9895672B2 (en) | 2009-09-10 | 2018-02-20 | DuPont Nutrition USA, Inc. | High strength seamless alginate capsules |
US20140261506A1 (en) * | 2009-10-09 | 2014-09-18 | Philip Morris Usa Inc. | Tobacco-free pouched product containing flavor beads providing immediate and long lasting flavor release |
US10143230B2 (en) * | 2009-10-09 | 2018-12-04 | Philip Morris Usa Inc. | Tobacco-free pouched product containing flavor beads providing immediate and long lasting flavor release |
US8604399B2 (en) | 2009-10-19 | 2013-12-10 | Exopack, Llc | Microwavable bags for use with liquid oil and related methods |
US20110089168A1 (en) * | 2009-10-19 | 2011-04-21 | Exopack, Llc | Microwavable bags for use with liquid oil and related methods |
US11672809B2 (en) | 2010-03-29 | 2023-06-13 | Eirgen Pharma Ltd. | Methods and compositions for reducing parathyroid levels |
KR101288079B1 (en) * | 2010-08-04 | 2013-07-22 | 알.피.쉐러 테크놀러지즈 엘엘씨 | Film-forming composition for soft capsules |
CN103228269A (en) * | 2010-08-04 | 2013-07-31 | R·P·舍勒科技有限责任公司 | Film-forming composition for soft capsules |
US20130189522A1 (en) * | 2010-08-04 | 2013-07-25 | R.P. Scherer Technologies, Llc | Film-forming composition for soft capsules |
CN103228269B (en) * | 2010-08-04 | 2015-06-17 | R·P·舍勒科技有限责任公司 | Film-forming composition for soft capsules |
WO2012018329A1 (en) * | 2010-08-04 | 2012-02-09 | R.P. Scherer Technologies, Llc | Film-forming composition for soft capsules |
WO2012126941A1 (en) * | 2011-03-22 | 2012-09-27 | Nordbloom Ltd | A composition and method |
US10350224B2 (en) | 2013-03-15 | 2019-07-16 | Opko Ireland Global Holdings, Ltd. | Stabilized modified release vitamin D formulation and method of administering same |
US9861644B2 (en) | 2013-03-15 | 2018-01-09 | Opko Ireland Global Holdings, Ltd. | Stabilized modified release vitamin D formulation and method of administering same |
US10300078B2 (en) | 2013-03-15 | 2019-05-28 | Opko Ireland Global Holdings, Ltd. | Stabilized modified release vitamin D formulation and method of administering same |
US10357502B2 (en) | 2013-03-15 | 2019-07-23 | Opko Ireland Global Holdings, Ltd. | Stabilized modified release vitamin D formulation and method of administering same |
US11253528B2 (en) | 2013-03-15 | 2022-02-22 | Eirgen Pharma Ltd. | Stabilized modified release Vitamin D formulation and method of administering same |
CN105051129B (en) * | 2013-03-29 | 2018-04-27 | 罗盖特公司 | Film-forming composition for the coating of solid form |
CN105051129A (en) * | 2013-03-29 | 2015-11-11 | 罗盖特公司 | Film-forming compostions for the film-coating of solid forms |
US11033504B2 (en) | 2013-03-29 | 2021-06-15 | Roquette Freres | Film-forming compositions for the film-coating of solid forms |
EP3013326A4 (en) * | 2013-06-25 | 2016-07-06 | Rp Scherer Technologies Llc | Shell-forming compositions for soft capsules and soft capsules |
WO2014209964A1 (en) * | 2013-06-25 | 2014-12-31 | R.P. Scherer Technologies, Llc | Shell-forming compositions for soft capsules and soft capsules |
US9814683B2 (en) | 2013-06-25 | 2017-11-14 | R.P. Scherer Technologies, Llc | Shell-forming compositions for soft capsules and soft capsules |
US9872513B2 (en) | 2013-07-01 | 2018-01-23 | Priscila F. Kimes | Processes in the preparation of coconut meat based compositions and films |
CN103520133A (en) * | 2013-10-26 | 2014-01-22 | 中山市凯博思淀粉材料科技有限公司 | Preparation method of starch-based soft capsules |
US9339053B2 (en) | 2013-10-26 | 2016-05-17 | Zhongshan Capsule Starch Material Technology Co., Ltd. | Preparation process of a self-reinforced starch composite used to produce capsules |
CN103893771B (en) * | 2014-04-21 | 2015-08-26 | 湖南尔康制药股份有限公司 | A kind of film-forming composition for the production of starch material soft capsule and preparation method thereof |
CN103893771A (en) * | 2014-04-21 | 2014-07-02 | 湖南同泰胶囊有限公司 | Film forming composition for producing soft starch material capsule and preparation method of film forming composition |
CN104059248A (en) * | 2014-06-27 | 2014-09-24 | 江南大学 | Method for improving properties of starch-base edible packaging film by adding hydrophilic colloid |
US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
US10493084B2 (en) | 2014-08-07 | 2019-12-03 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
US11738033B2 (en) | 2014-08-07 | 2023-08-29 | Eirgen Pharma Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
US11007205B2 (en) | 2014-08-07 | 2021-05-18 | Eirgen Pharma Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
US10184765B1 (en) * | 2015-04-21 | 2019-01-22 | Briana Gardell | Throwable paint balls and method of manufacture |
CN107847454B (en) * | 2015-08-06 | 2023-09-12 | 罗盖特公司 | Film-forming compositions based on starch materials and articles obtained therefrom |
US11278625B2 (en) | 2015-08-06 | 2022-03-22 | Roquette Freres | Film-forming compositions based on starchy material and articles obtained thereof |
CN107847454A (en) * | 2015-08-06 | 2018-03-27 | 罗盖特公司 | Film-forming composition based on starch material and the product by its acquisition |
WO2017021533A1 (en) * | 2015-08-06 | 2017-02-09 | Roquette Freres | Film-forming compositions based on starchy material and articles obtained thereof |
AU2016303022B2 (en) * | 2015-08-06 | 2021-05-27 | Roquette Freres | Film-forming compositions based on starchy material and articles obtained thereof |
US9968560B2 (en) * | 2015-12-18 | 2018-05-15 | Mun Gu KIM | Composition for preparing soft capsule shell |
KR101675438B1 (en) * | 2015-12-18 | 2016-11-11 | 김문구 | Composition for preparing soft capsule shell |
US11173168B2 (en) | 2016-03-28 | 2021-11-16 | Eirgen Pharma Ltd. | Methods of treating vitamin D insufficiency in chronic kidney disease |
WO2018146165A1 (en) * | 2017-02-08 | 2018-08-16 | Roquette Freres | Film-forming compositions for hard capsule shells and hard capsule shells obtained thereof |
JP2020507642A (en) * | 2017-02-08 | 2020-03-12 | ロケット フレールRoquette Freres | Film-forming composition for hard capsule shell and hard capsule shell obtained therefrom |
CN110300577B (en) * | 2017-02-08 | 2022-04-05 | 罗盖特公司 | Film-forming composition for hard capsule shells and hard capsule shells obtained therefrom |
EP3360544A1 (en) * | 2017-02-08 | 2018-08-15 | Roquette Freres | Film-forming compositions for hard capsule shells and hard capsule shells obtained thereof |
US11040105B2 (en) | 2017-02-08 | 2021-06-22 | Roquette Freres | Film-forming compositions for hard capsule shells and hard capsule shells obtained thereof |
KR20190111928A (en) * | 2017-02-08 | 2019-10-02 | 로께뜨프레르 | Film forming compositions for hard capsule shells and hard capsule shells obtained therefrom |
CN110300577A (en) * | 2017-02-08 | 2019-10-01 | 罗盖特公司 | Film-forming composition for hard capsule case and the hard capsule case by its acquisition |
CN111116949A (en) * | 2018-10-31 | 2020-05-08 | 齐鲁工业大学 | Preparation method of double-enzyme modified composite edible film with slow digestion characteristic |
CN113121889A (en) * | 2019-12-30 | 2021-07-16 | 仙乐健康科技股份有限公司 | Starch film-forming composition and application thereof in plant soft capsules |
US11560439B2 (en) * | 2020-04-24 | 2023-01-24 | Hunan Er-Kang Pharmaceutical Co., Ltd. | Hydroxypropyl starch for preparing empty capsules and hydroxypropyl starch-based soft capsules |
WO2022226217A1 (en) | 2021-04-22 | 2022-10-27 | Civi Biopharma, Inc. | Oral delivery of oligonucleotides |
Also Published As
Publication number | Publication date |
---|---|
WO2001091721A3 (en) | 2002-05-30 |
WO2001091721A2 (en) | 2001-12-06 |
AU2001259644A1 (en) | 2001-12-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6375981B1 (en) | Modified starch as a replacement for gelatin in soft gel films and capsules | |
US6528088B1 (en) | Highly flexible starch-based films | |
JP4065691B2 (en) | Pullulan film composition | |
US3865603A (en) | Modified starch-extended gelatin compositions | |
US20060240099A1 (en) | High-amylose starch | |
EP1570843B1 (en) | Blends of different acyl gellan gums and starch | |
US6210709B1 (en) | Flexible gelatin free encapsulation material useful for pharmaceuticals, paint balls and other formulations | |
JP4374497B2 (en) | Edible film | |
JP2007536308A (en) | Improved pullulan capsule | |
US20070034827A1 (en) | Blends of gelling and non-gelling starches with gellan gums and plasticizer | |
JP2004508321A (en) | Dry powder film coating composition and method for producing the same | |
CN107847454B (en) | Film-forming compositions based on starch materials and articles obtained therefrom | |
US20070128267A1 (en) | Blends of gelling and non-gelling starches with gellan gums and plasticizer | |
CN107936311B (en) | Edible film based on Sanzan glue crosslinking modification and preparation method and application thereof | |
JP4743690B2 (en) | Starch-based water-soluble film | |
EP1292639B1 (en) | Highly flexible starch-based films | |
KR100483072B1 (en) | Film-forming composition suitable for hard capsules and method for preparing the same | |
JP4393957B2 (en) | Soft capsule manufacturing method | |
JP2011026262A (en) | Method for manufacturing soft capsule | |
JP4500000B2 (en) | Capsule coating composition | |
JPH08169817A (en) | Capsule | |
MXPA02000739A (en) | Pullulan film compositions |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: A.E. STALEY MANUFACTURING CO, ILLINOIS Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:GILLELAND, G.M.;TURNER, J.L.;PATTON, P.A.;AND OTHERS;REEL/FRAME:010839/0477 Effective date: 20000511 |
|
STCF | Information on status: patent grant |
Free format text: PATENTED CASE |
|
FEPP | Fee payment procedure |
Free format text: PAYER NUMBER DE-ASSIGNED (ORIGINAL EVENT CODE: RMPN); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY Free format text: PAYOR NUMBER ASSIGNED (ORIGINAL EVENT CODE: ASPN); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY |
|
FPAY | Fee payment |
Year of fee payment: 4 |
|
AS | Assignment |
Owner name: TATE & LYLE INGREDIENTS AMERICAS, INC., ILLINOIS Free format text: CHANGE OF NAME;ASSIGNOR:A.E. STALEY MANUFACTURING COMPANY;REEL/FRAME:017519/0352 Effective date: 20041213 |
|
FPAY | Fee payment |
Year of fee payment: 8 |
|
FPAY | Fee payment |
Year of fee payment: 12 |
|
FEPP | Fee payment procedure |
Free format text: PAYOR NUMBER ASSIGNED (ORIGINAL EVENT CODE: ASPN); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY Free format text: PAYER NUMBER DE-ASSIGNED (ORIGINAL EVENT CODE: RMPN); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY |