US5851181A - Apparatus for simultaneously viewing and spectrally analyzing a portion of skin - Google Patents
Apparatus for simultaneously viewing and spectrally analyzing a portion of skin Download PDFInfo
- Publication number
- US5851181A US5851181A US08/708,080 US70808096A US5851181A US 5851181 A US5851181 A US 5851181A US 70808096 A US70808096 A US 70808096A US 5851181 A US5851181 A US 5851181A
- Authority
- US
- United States
- Prior art keywords
- housing
- opening
- disposed
- camera
- coupled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
- A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
- A61B5/444—Evaluating skin marks, e.g. mole, nevi, tumour, scar
Definitions
- the light source used to stimulate the photosensitivity agent was removed from the proximity of the treatment site and a spectrometer was placed in proximity to the treatment site. This process was repeated each time the spectral emissions from the treatment site was checked until the photosensitizing agent was consumed.
- the light source should have been replaced back at the identical spot from which it was removed to apply light to the identical area. This often did not happen, however. Each time the light source was replaced, it was often replaced at a slightly different location. In this manner, the light source "migrates" across the treatment site causing irregular and nonhomogeneous treatment of the tumor.
- the present invention is directed to a special monitoring apparatus including a housing having an opening adapted to be disposed adjacent to a portion of a treatment site, a camera coupled to the housing to view the opening, and a spectrometer optically coupled to the housing and disposed to sense radiation entering the housing at the opening.
- the spectrometer may include an optical bench disposed remotely from the housing and coupled to a first end of an optical fiber, wherein the second end of the optical fiber is coupled to the housing and disposed such that it receives radiation entering the housing through the opening.
- At least one lens may be provided to focus light entering the housing into the second end of the optical fiber.
- a window may be provided that is disposed across the opening in the field of view of the camera and between the camera and the opening.
- the apparatus may also include a computer display coupled to the computer and adapted to display a spectral distribution calculated by the computer from the spectral signal and transmitted by the computer to the display as well as an image received by the computer from the camera.
- the display may be adapted to display both an image and a spectral distribution simultaneously.
- FIG. 2 is a partial cross-sectional diagram of a monitoring apparatus in accordance with the present invention.
- a window 30 is provided that extends across the opening 14.
- Light guide 24 is coupled to the window, preferably in the field of view of the camera such that an image produced by the camera indicates the point at which the light guide is coupled to the window.
- the light guide preferably receives light emitted from a spot on the treatment site measuring between 1 and 10 mm 2 .
- the window transmits light from the light source out of the housing and onto the treatment site. It also transmits light emitted from the treatment site into the housing and thence into the camera.
- the optical fiber preferably extends through the window such that it receives light emitted directly from the treatment site without having to pass through the window.
- the inner and outer surfaces of the window preferably have an anti-reflective coating to attenuate any reflections internal to the housing from entering the camera.
- Window 30 is preferably recessed within opening 14 of housing 12. The depth of this recess is preferably between 3 and 10 mm.
- a portion of light guide 24 is disposed in the optical path of the camera, and thus tends to partially obstruct the camera's view. While this obstruction cannot be eliminated in the FIG. 2 embodiment, it may be significantly reduced by providing a light guide 24 having a diameter of between 0.1 and 1 mm. A light guide of this diameter provides a minimum of interference with the camera's image, while also conducting sufficient light from a range of 1 to 10 mm 2 area of the treatment site to provide a good spectral analysis of the treatment site.
- FIG. 5 discloses a monitoring apparatus similar to any of the above embodiments and further including a computer 38 coupled to spectrometer 20, camera 18 and computer display 40.
- Computer 38 receives signals from spectrometer 20 indicative of the spectrum of light received by spectrometer 20. These signals are processed by the computer which then transmits an electrical signal to display 40 causing display 40 to generate a representation of the spectrum 42 on the display.
- the spectrum is shown in graphical form as a function on display 40, in which the horizontal or X-axis indicates the frequency or wavelength of light received by the spectrometer, and the vertical or Y-axis indicates a value indicative of the relative intensity of light received by the spectrometer.
Abstract
Description
Claims (5)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/708,080 US5851181A (en) | 1996-08-30 | 1996-08-30 | Apparatus for simultaneously viewing and spectrally analyzing a portion of skin |
CA002212396A CA2212396A1 (en) | 1996-08-30 | 1997-08-06 | Monitoring apparatus |
AU33252/97A AU717103B2 (en) | 1996-08-30 | 1997-08-11 | Apparatus for simultaneously viewing and spectrally analyzing a portion of skin |
EP97114468A EP0826335A1 (en) | 1996-08-30 | 1997-08-21 | Spectral monitoring apparatus |
JP9234833A JPH1085222A (en) | 1996-08-30 | 1997-08-29 | Spectrum monitoring device |
KR1019970043560A KR19980019193A (en) | 1996-08-30 | 1997-08-30 | Spectrum Monitor Device (MONITORING DEVICE) |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/708,080 US5851181A (en) | 1996-08-30 | 1996-08-30 | Apparatus for simultaneously viewing and spectrally analyzing a portion of skin |
Publications (1)
Publication Number | Publication Date |
---|---|
US5851181A true US5851181A (en) | 1998-12-22 |
Family
ID=24844304
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/708,080 Expired - Lifetime US5851181A (en) | 1996-08-30 | 1996-08-30 | Apparatus for simultaneously viewing and spectrally analyzing a portion of skin |
Country Status (6)
Country | Link |
---|---|
US (1) | US5851181A (en) |
EP (1) | EP0826335A1 (en) |
JP (1) | JPH1085222A (en) |
KR (1) | KR19980019193A (en) |
AU (1) | AU717103B2 (en) |
CA (1) | CA2212396A1 (en) |
Cited By (76)
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WO1999022814A1 (en) | 1997-10-30 | 1999-05-14 | Esc Medical Systems Ltd. | System and method for endoscopically applying and monitoring photodynamic therapy and photodynamic diagnosis |
WO1999027343A3 (en) * | 1997-11-26 | 1999-08-12 | Imaging Diagnostic Systems Inc | Time-resolved breast imaging device |
US6032071A (en) * | 1994-12-01 | 2000-02-29 | Norbert Artner | Skin examination device |
US6129667A (en) * | 1998-02-02 | 2000-10-10 | General Electric Company | Luminal diagnostics employing spectral analysis |
US6148223A (en) * | 1997-04-04 | 2000-11-14 | Davis; James M. | Transilluminator device |
WO2001003770A1 (en) * | 1999-07-08 | 2001-01-18 | Light Sciences Corporation | Combined imaging and pdt delivery system |
DE19934038A1 (en) * | 1999-07-20 | 2001-02-08 | Gesellschaft Zur Foerderung Von Medizin-,Bio- Und Umwelttechnologien Ev | Device for spectral photometric diagnosis of healthy and sick skin tissue has transmission devices for illuminating skin surface and on remission measurement head light output side |
US6217512B1 (en) * | 1997-12-12 | 2001-04-17 | Program For Appropriate Technology In Health | Self-illuminated, non-invasive, visual cervical inspection apparatus and method |
US6324418B1 (en) * | 1997-09-29 | 2001-11-27 | Boston Scientific Corporation | Portable tissue spectroscopy apparatus and method |
GB2364567A (en) * | 2000-07-07 | 2002-01-30 | Astron Clinica Ltd | Determining distribution of chromophores in skin or other epithelial tissue |
US6345191B1 (en) * | 1999-03-29 | 2002-02-05 | F. Hoffman-La Roche Ag | System for quantitative determination of the local distribution of a quantity to be measured |
US6383177B1 (en) | 1997-08-29 | 2002-05-07 | Asah Medico A/S | Apparatus for tissue treatment |
US6418339B1 (en) * | 1997-05-26 | 2002-07-09 | Matthias Essenpreis | Method and apparatus for determining the lines of optimal direction for surgical cuts in the human skin |
US6424852B1 (en) * | 1996-10-18 | 2002-07-23 | Lucid, Inc. | System for confocal imaging within dermal tissue |
US20030050561A1 (en) * | 2001-07-09 | 2003-03-13 | L'oreal | System and method for evaluating a characteristic of body typology |
US6587711B1 (en) * | 1999-07-22 | 2003-07-01 | The Research Foundation Of Cuny | Spectral polarizing tomographic dermatoscope |
US20030130562A1 (en) * | 2002-01-09 | 2003-07-10 | Scimed Life Systems, Inc. | Imaging device and related methods |
US6676654B1 (en) | 1997-08-29 | 2004-01-13 | Asah Medico A/S | Apparatus for tissue treatment and having a monitor for display of tissue features |
US20040092802A1 (en) * | 2000-07-07 | 2004-05-13 | Cane Michael Roger | Epithelial diagnostic aid |
US20040111031A1 (en) * | 1999-07-22 | 2004-06-10 | Alfano Robert R. | Spectral polarizing tomographic dermatoscope |
US20040186363A1 (en) * | 1999-09-30 | 2004-09-23 | Smit Andries Jan | Method and apparatus for determining autofluorescence of skin tissue |
US20050038418A1 (en) * | 1997-05-15 | 2005-02-17 | Palomar Medical Technologies, Inc. | Light energy delivery head |
US20050154276A1 (en) * | 2002-03-28 | 2005-07-14 | Alessandro Barducci | Apparatus and process for reading radiation reflected from human skin |
US20050182321A1 (en) * | 2002-03-12 | 2005-08-18 | Beth Israel Deaconess Medical Center | Medical imaging systems |
US20070206275A1 (en) * | 2006-02-17 | 2007-09-06 | Paul Hemmer | System for macroscopic and confocal imaging of tissue |
US20070264625A1 (en) * | 2006-05-11 | 2007-11-15 | Reliant Technologies, Inc. | Apparatus and Method for Ablation-Related Dermatological Treatment of Selected Targets |
US20070264626A1 (en) * | 2006-05-11 | 2007-11-15 | Reliant Technologies, Inc. | Apparatus and Method for a Combination of Ablative and Nonablative Dermatological Treatment |
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US20080068604A1 (en) * | 2006-09-19 | 2008-03-20 | Seethrough Ltd. | Device and method for inspecting a hair sample |
US20080147053A1 (en) * | 2006-12-15 | 2008-06-19 | Korea Electro Technology Research Institute | Apparatus and method for photodynamic diagnosis and therapy of skin diseases and light source system thereof |
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US20080269576A1 (en) * | 2006-03-29 | 2008-10-30 | Uk Kang | Light Source for Fluorescence Diagnosis and Photodynamic Therapy |
US20090118600A1 (en) * | 2007-11-02 | 2009-05-07 | Ortiz Joseph L | Method and apparatus for skin documentation and analysis |
US20100137710A1 (en) * | 1996-10-18 | 2010-06-03 | Zavislan James M | System for marking the locations of imaged tissue with respect to the surface of the tissue |
US7758621B2 (en) | 1997-05-15 | 2010-07-20 | Palomar Medical Technologies, Inc. | Method and apparatus for therapeutic EMR treatment on the skin |
US20100305436A1 (en) * | 2007-09-14 | 2010-12-02 | Light Sciences Oncology , Inc. | Systems, devices, and methods for photoactive assisted resection |
US7942915B2 (en) | 2002-05-23 | 2011-05-17 | Palomar Medical Technologies, Inc. | Phototreatment device for use with coolants |
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US8182473B2 (en) | 1999-01-08 | 2012-05-22 | Palomar Medical Technologies | Cooling system for a photocosmetic device |
US8268332B2 (en) | 2004-04-01 | 2012-09-18 | The General Hospital Corporation | Method for dermatological treatment using chromophores |
US8328794B2 (en) | 1996-12-02 | 2012-12-11 | Palomar Medical Technologies, Inc. | System for electromagnetic radiation dermatology and head for use therewith |
US8346347B2 (en) | 2005-09-15 | 2013-01-01 | Palomar Medical Technologies, Inc. | Skin optical characterization device |
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US20130217984A1 (en) * | 2010-06-18 | 2013-08-22 | Diagnoptics Holding B.V. | Method and apparatus for determining an autofluorescence value of skin tissue |
US20130274834A1 (en) * | 2006-04-18 | 2013-10-17 | Daniel Barolet | Method for the treatment of skin tissues. |
US20130345685A1 (en) * | 2012-06-22 | 2013-12-26 | Epilady 2000, Llc | Aesthetic treatment device and method |
US8915948B2 (en) | 2002-06-19 | 2014-12-23 | Palomar Medical Technologies, Llc | Method and apparatus for photothermal treatment of tissue at depth |
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US9028536B2 (en) | 2006-08-02 | 2015-05-12 | Cynosure, Inc. | Picosecond laser apparatus and methods for its operation and use |
US9421280B2 (en) | 2005-04-26 | 2016-08-23 | Novadaq Technologies Inc. | Real time imaging during solid organ transplant |
US20160256707A1 (en) * | 2012-06-22 | 2016-09-08 | S & Y Enterprises Llc | Aesthetic treatment device and method |
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4336809A (en) * | 1980-03-17 | 1982-06-29 | Burleigh Instruments, Inc. | Human and animal tissue photoradiation system and method |
US4768513A (en) * | 1986-04-21 | 1988-09-06 | Agency Of Industrial Science And Technology | Method and device for measuring and processing light |
US5293872A (en) * | 1991-04-03 | 1994-03-15 | Alfano Robert R | Method for distinguishing between calcified atherosclerotic tissue and fibrous atherosclerotic tissue or normal cardiovascular tissue using Raman spectroscopy |
US5363854A (en) * | 1990-08-24 | 1994-11-15 | U.S. Philips Corporation | Method of detecting anomalies of the skin, more particularly melanomae, and apparatus for carrying out the method |
US5383467A (en) * | 1992-11-18 | 1995-01-24 | Spectrascience, Inc. | Guidewire catheter and apparatus for diagnostic imaging |
US5608520A (en) * | 1994-07-11 | 1997-03-04 | The United States Of America As Represented By He Department Of Energy | Plasma emission spectroscopy method of tumor therapy |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3718202C1 (en) * | 1987-05-29 | 1988-11-17 | Wolfgang Prof Dr Lohmann | Arrangement for measuring a condition value for organic tissue areas |
US5018531A (en) * | 1989-09-07 | 1991-05-28 | Hartman William B | Skin blemish measuring and recording system and method |
FR2719989B1 (en) * | 1994-05-20 | 1996-07-05 | Oreal | Method for the determination of quantities characteristic of the behavior of a surface, in particular of human skin, subjected to light radiation, and apparatus for its implementation. |
JPH08145794A (en) * | 1994-11-17 | 1996-06-07 | Shimadzu Corp | Spectroscope |
JP3579686B2 (en) * | 1995-08-07 | 2004-10-20 | アークレイ株式会社 | Measuring position reproducing method, measuring position reproducing device, and optical measuring device using the same |
US5813403A (en) * | 1995-11-08 | 1998-09-29 | Soller; Babs R. | Optical measurement of tissue pH |
-
1996
- 1996-08-30 US US08/708,080 patent/US5851181A/en not_active Expired - Lifetime
-
1997
- 1997-08-06 CA CA002212396A patent/CA2212396A1/en not_active Abandoned
- 1997-08-11 AU AU33252/97A patent/AU717103B2/en not_active Ceased
- 1997-08-21 EP EP97114468A patent/EP0826335A1/en not_active Withdrawn
- 1997-08-29 JP JP9234833A patent/JPH1085222A/en active Pending
- 1997-08-30 KR KR1019970043560A patent/KR19980019193A/en not_active Application Discontinuation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4336809A (en) * | 1980-03-17 | 1982-06-29 | Burleigh Instruments, Inc. | Human and animal tissue photoradiation system and method |
US4768513A (en) * | 1986-04-21 | 1988-09-06 | Agency Of Industrial Science And Technology | Method and device for measuring and processing light |
US5363854A (en) * | 1990-08-24 | 1994-11-15 | U.S. Philips Corporation | Method of detecting anomalies of the skin, more particularly melanomae, and apparatus for carrying out the method |
US5293872A (en) * | 1991-04-03 | 1994-03-15 | Alfano Robert R | Method for distinguishing between calcified atherosclerotic tissue and fibrous atherosclerotic tissue or normal cardiovascular tissue using Raman spectroscopy |
US5383467A (en) * | 1992-11-18 | 1995-01-24 | Spectrascience, Inc. | Guidewire catheter and apparatus for diagnostic imaging |
US5608520A (en) * | 1994-07-11 | 1997-03-04 | The United States Of America As Represented By He Department Of Energy | Plasma emission spectroscopy method of tumor therapy |
Non-Patent Citations (4)
Title |
---|
Laser Spectroscopy in Medical Diagnostics, Andersson Engels, et al., Chapter 24, pp. 387 417. * |
Laser Spectroscopy in Medical Diagnostics, Andersson-Engels, et al., Chapter 24, pp. 387-417. |
Optical Biopsy Detecting Cancer With Light, Katz, et al., Hot Topics, Leos Newsletter, pp. 6 7, Feb. 1996. * |
Optical Biopsy --Detecting Cancer With Light, Katz, et al., Hot Topics, Leos Newsletter, pp. 6-7, Feb. 1996. |
Cited By (137)
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US6032071A (en) * | 1994-12-01 | 2000-02-29 | Norbert Artner | Skin examination device |
US6424852B1 (en) * | 1996-10-18 | 2002-07-23 | Lucid, Inc. | System for confocal imaging within dermal tissue |
US20070287921A1 (en) * | 1996-10-18 | 2007-12-13 | Zavislan James M | System for confocal imaging within dermal tissue |
US20050171441A1 (en) * | 1996-10-18 | 2005-08-04 | Zavislan James M. | System for confocal imaging within dermal tissue |
US20020151782A1 (en) * | 1996-10-18 | 2002-10-17 | Zavislan James M. | System for confocal imaging within dermal tissue |
US8121670B2 (en) | 1996-10-18 | 2012-02-21 | Lucid, Inc. | System for confocal imaging within dermal tissue |
US20100137710A1 (en) * | 1996-10-18 | 2010-06-03 | Zavislan James M | System for marking the locations of imaged tissue with respect to the surface of the tissue |
US8606343B2 (en) | 1996-10-18 | 2013-12-10 | Lucid, Inc. | System and method for confocal imaging within dermal tissue |
US7225010B1 (en) | 1996-10-18 | 2007-05-29 | Lucid, Inc. | System and method for confocal imaging within dermal tissue |
US6937886B2 (en) | 1996-10-18 | 2005-08-30 | Lucid, Inc. | System for confocal imaging within dermal tissue |
US8328794B2 (en) | 1996-12-02 | 2012-12-11 | Palomar Medical Technologies, Inc. | System for electromagnetic radiation dermatology and head for use therewith |
US6148223A (en) * | 1997-04-04 | 2000-11-14 | Davis; James M. | Transilluminator device |
US7935107B2 (en) | 1997-05-15 | 2011-05-03 | Palomar Medical Technologies, Inc. | Heads for dermatology treatment |
US7758621B2 (en) | 1997-05-15 | 2010-07-20 | Palomar Medical Technologies, Inc. | Method and apparatus for therapeutic EMR treatment on the skin |
US7763016B2 (en) | 1997-05-15 | 2010-07-27 | Palomar Medical Technologies, Inc. | Light energy delivery head |
US8328796B2 (en) | 1997-05-15 | 2012-12-11 | Palomar Medical Technologies, Inc. | Light energy delivery head |
US8109924B2 (en) | 1997-05-15 | 2012-02-07 | Palomar Medical Technologies, Inc. | Heads for dermatology treatment |
US20050038418A1 (en) * | 1997-05-15 | 2005-02-17 | Palomar Medical Technologies, Inc. | Light energy delivery head |
US8002768B1 (en) | 1997-05-15 | 2011-08-23 | Palomar Medical Technologies, Inc. | Light energy delivery head |
US6418339B1 (en) * | 1997-05-26 | 2002-07-09 | Matthias Essenpreis | Method and apparatus for determining the lines of optimal direction for surgical cuts in the human skin |
US6383177B1 (en) | 1997-08-29 | 2002-05-07 | Asah Medico A/S | Apparatus for tissue treatment |
USRE38670E1 (en) | 1997-08-29 | 2004-12-14 | Asah Medico A/S | Apparatus for tissue treatment |
US6676654B1 (en) | 1997-08-29 | 2004-01-13 | Asah Medico A/S | Apparatus for tissue treatment and having a monitor for display of tissue features |
US6324418B1 (en) * | 1997-09-29 | 2001-11-27 | Boston Scientific Corporation | Portable tissue spectroscopy apparatus and method |
WO1999022814A1 (en) | 1997-10-30 | 1999-05-14 | Esc Medical Systems Ltd. | System and method for endoscopically applying and monitoring photodynamic therapy and photodynamic diagnosis |
US6339216B1 (en) | 1997-11-26 | 2002-01-15 | Imaging Diagnostic Systems, Inc. | Time-resolved breast imaging device |
WO1999027343A3 (en) * | 1997-11-26 | 1999-08-12 | Imaging Diagnostic Systems Inc | Time-resolved breast imaging device |
US6217512B1 (en) * | 1997-12-12 | 2001-04-17 | Program For Appropriate Technology In Health | Self-illuminated, non-invasive, visual cervical inspection apparatus and method |
US6129667A (en) * | 1998-02-02 | 2000-10-10 | General Electric Company | Luminal diagnostics employing spectral analysis |
US8182473B2 (en) | 1999-01-08 | 2012-05-22 | Palomar Medical Technologies | Cooling system for a photocosmetic device |
US6345191B1 (en) * | 1999-03-29 | 2002-02-05 | F. Hoffman-La Roche Ag | System for quantitative determination of the local distribution of a quantity to be measured |
US6210425B1 (en) * | 1999-07-08 | 2001-04-03 | Light Sciences Corporation | Combined imaging and PDT delivery system |
WO2001003770A1 (en) * | 1999-07-08 | 2001-01-18 | Light Sciences Corporation | Combined imaging and pdt delivery system |
DE19934038A1 (en) * | 1999-07-20 | 2001-02-08 | Gesellschaft Zur Foerderung Von Medizin-,Bio- Und Umwelttechnologien Ev | Device for spectral photometric diagnosis of healthy and sick skin tissue has transmission devices for illuminating skin surface and on remission measurement head light output side |
US20040111031A1 (en) * | 1999-07-22 | 2004-06-10 | Alfano Robert R. | Spectral polarizing tomographic dermatoscope |
US6587711B1 (en) * | 1999-07-22 | 2003-07-01 | The Research Foundation Of Cuny | Spectral polarizing tomographic dermatoscope |
US7881777B2 (en) | 1999-09-24 | 2011-02-01 | National Research Council Of Canada | Method and apparatus for performing intra-operative angiography |
US20080071176A1 (en) * | 1999-09-24 | 2008-03-20 | National Research Council Of Canada | Method and apparatus for performing intra-operative angiography |
US8892190B2 (en) | 1999-09-24 | 2014-11-18 | National Research Council Of Canada | Method and apparatus for performing intra-operative angiography |
US20040186363A1 (en) * | 1999-09-30 | 2004-09-23 | Smit Andries Jan | Method and apparatus for determining autofluorescence of skin tissue |
US7966060B2 (en) | 1999-09-30 | 2011-06-21 | Diagnoptics Holding B.V. | Method and apparatus for determining autofluorescence of skin tissue |
GB2364567A (en) * | 2000-07-07 | 2002-01-30 | Astron Clinica Ltd | Determining distribution of chromophores in skin or other epithelial tissue |
US20040092802A1 (en) * | 2000-07-07 | 2004-05-13 | Cane Michael Roger | Epithelial diagnostic aid |
US20030050561A1 (en) * | 2001-07-09 | 2003-03-13 | L'oreal | System and method for evaluating a characteristic of body typology |
US8423110B2 (en) * | 2002-01-09 | 2013-04-16 | Boston Scientific Scimed, Inc. | Imaging device and related methods |
US20030130562A1 (en) * | 2002-01-09 | 2003-07-10 | Scimed Life Systems, Inc. | Imaging device and related methods |
US8229548B2 (en) * | 2002-03-12 | 2012-07-24 | Beth Israel Deaconess Medical Center | Medical imaging systems |
US20050182321A1 (en) * | 2002-03-12 | 2005-08-18 | Beth Israel Deaconess Medical Center | Medical imaging systems |
US20050154276A1 (en) * | 2002-03-28 | 2005-07-14 | Alessandro Barducci | Apparatus and process for reading radiation reflected from human skin |
US7942915B2 (en) | 2002-05-23 | 2011-05-17 | Palomar Medical Technologies, Inc. | Phototreatment device for use with coolants |
US7942916B2 (en) | 2002-05-23 | 2011-05-17 | Palomar Medical Technologies, Inc. | Phototreatment device for use with coolants and topical substances |
US10556123B2 (en) | 2002-06-19 | 2020-02-11 | Palomar Medical Technologies, Llc | Method and apparatus for treatment of cutaneous and subcutaneous conditions |
US8915948B2 (en) | 2002-06-19 | 2014-12-23 | Palomar Medical Technologies, Llc | Method and apparatus for photothermal treatment of tissue at depth |
US10500413B2 (en) | 2002-06-19 | 2019-12-10 | Palomar Medical Technologies, Llc | Method and apparatus for treatment of cutaneous and subcutaneous conditions |
US8268332B2 (en) | 2004-04-01 | 2012-09-18 | The General Hospital Corporation | Method for dermatological treatment using chromophores |
US9452013B2 (en) | 2004-04-01 | 2016-09-27 | The General Hospital Corporation | Apparatus for dermatological treatment using chromophores |
US10434324B2 (en) | 2005-04-22 | 2019-10-08 | Cynosure, Llc | Methods and systems for laser treatment using non-uniform output beam |
US9421280B2 (en) | 2005-04-26 | 2016-08-23 | Novadaq Technologies Inc. | Real time imaging during solid organ transplant |
US10265419B2 (en) | 2005-09-02 | 2019-04-23 | Novadaq Technologies ULC | Intraoperative determination of nerve location |
US8346347B2 (en) | 2005-09-15 | 2013-01-01 | Palomar Medical Technologies, Inc. | Skin optical characterization device |
US7864996B2 (en) | 2006-02-17 | 2011-01-04 | Lucid, Inc. | System for macroscopic and confocal imaging of tissue |
US20070206275A1 (en) * | 2006-02-17 | 2007-09-06 | Paul Hemmer | System for macroscopic and confocal imaging of tissue |
US8175687B2 (en) * | 2006-03-29 | 2012-05-08 | Korea Electro Technology Research Institute | Light source for fluorescence diagnosis and photodynamic therapy |
US20080269576A1 (en) * | 2006-03-29 | 2008-10-30 | Uk Kang | Light Source for Fluorescence Diagnosis and Photodynamic Therapy |
US20130274834A1 (en) * | 2006-04-18 | 2013-10-17 | Daniel Barolet | Method for the treatment of skin tissues. |
US20070264626A1 (en) * | 2006-05-11 | 2007-11-15 | Reliant Technologies, Inc. | Apparatus and Method for a Combination of Ablative and Nonablative Dermatological Treatment |
US20070264625A1 (en) * | 2006-05-11 | 2007-11-15 | Reliant Technologies, Inc. | Apparatus and Method for Ablation-Related Dermatological Treatment of Selected Targets |
US9028536B2 (en) | 2006-08-02 | 2015-05-12 | Cynosure, Inc. | Picosecond laser apparatus and methods for its operation and use |
US11712299B2 (en) | 2006-08-02 | 2023-08-01 | Cynosure, LLC. | Picosecond laser apparatus and methods for its operation and use |
US10849687B2 (en) | 2006-08-02 | 2020-12-01 | Cynosure, Llc | Picosecond laser apparatus and methods for its operation and use |
US10966785B2 (en) | 2006-08-02 | 2021-04-06 | Cynosure, Llc | Picosecond laser apparatus and methods for its operation and use |
US10434190B2 (en) | 2006-09-07 | 2019-10-08 | Novadaq Technologies ULC | Pre-and-intra-operative localization of penile sentinel nodes |
US20080068604A1 (en) * | 2006-09-19 | 2008-03-20 | Seethrough Ltd. | Device and method for inspecting a hair sample |
US7508508B2 (en) * | 2006-09-19 | 2009-03-24 | Seethrough Ltd. | Device and method for inspecting a hair sample |
US20080147053A1 (en) * | 2006-12-15 | 2008-06-19 | Korea Electro Technology Research Institute | Apparatus and method for photodynamic diagnosis and therapy of skin diseases and light source system thereof |
US8496695B2 (en) * | 2006-12-15 | 2013-07-30 | Korea Electro Technology Research Institute | Apparatus and method for photodynamic diagnosis and therapy of skin diseases and light source system thereof |
US20080154247A1 (en) * | 2006-12-20 | 2008-06-26 | Reliant Technologies, Inc. | Apparatus and method for hair removal and follicle devitalization |
US20100305436A1 (en) * | 2007-09-14 | 2010-12-02 | Light Sciences Oncology , Inc. | Systems, devices, and methods for photoactive assisted resection |
US20090118600A1 (en) * | 2007-11-02 | 2009-05-07 | Ortiz Joseph L | Method and apparatus for skin documentation and analysis |
US11564583B2 (en) | 2008-01-25 | 2023-01-31 | Stryker European Operations Limited | Method for evaluating blush in myocardial tissue |
US9936887B2 (en) | 2008-01-25 | 2018-04-10 | Novadaq Technologies ULC | Method for evaluating blush in myocardial tissue |
US10835138B2 (en) | 2008-01-25 | 2020-11-17 | Stryker European Operations Limited | Method for evaluating blush in myocardial tissue |
US9610021B2 (en) | 2008-01-25 | 2017-04-04 | Novadaq Technologies Inc. | Method for evaluating blush in myocardial tissue |
US10219742B2 (en) | 2008-04-14 | 2019-03-05 | Novadaq Technologies ULC | Locating and analyzing perforator flaps for plastic and reconstructive surgery |
US10041042B2 (en) | 2008-05-02 | 2018-08-07 | Novadaq Technologies ULC | Methods for production and use of substance-loaded erythrocytes (S-IEs) for observation and treatment of microvascular hemodynamics |
US11284800B2 (en) | 2008-05-20 | 2022-03-29 | University Health Network | Devices, methods, and systems for fluorescence-based endoscopic imaging and collection of data with optical filters with corresponding discrete spectral bandwidth |
US9042967B2 (en) | 2008-05-20 | 2015-05-26 | University Health Network | Device and method for wound imaging and monitoring |
US11154198B2 (en) | 2008-05-20 | 2021-10-26 | University Health Network | Method and system for imaging and collection of data for diagnostic purposes |
US20110117025A1 (en) * | 2008-05-20 | 2011-05-19 | Ralph Sebastian Dacosta | Device and method for fluorescence-based imaging and monitoring |
US11375898B2 (en) | 2008-05-20 | 2022-07-05 | University Health Network | Method and system with spectral filtering and thermal mapping for imaging and collection of data for diagnostic purposes from bacteria |
US10492671B2 (en) | 2009-05-08 | 2019-12-03 | Novadaq Technologies ULC | Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest |
US9919168B2 (en) | 2009-07-23 | 2018-03-20 | Palomar Medical Technologies, Inc. | Method for improvement of cellulite appearance |
US20130217984A1 (en) * | 2010-06-18 | 2013-08-22 | Diagnoptics Holding B.V. | Method and apparatus for determining an autofluorescence value of skin tissue |
US9205283B2 (en) | 2011-03-21 | 2015-12-08 | Coloright Ltd. | Systems for custom coloration |
US10046183B2 (en) | 2011-03-21 | 2018-08-14 | Coloright Ltd. | Systems for custom coloration |
GB2503623A (en) * | 2011-03-21 | 2014-01-01 | Coloright Ltd | Systems for custom coloration |
WO2012127429A3 (en) * | 2011-03-21 | 2013-01-03 | Coloright Ltd. | Systems for custom coloration |
GB2503623B (en) * | 2011-03-21 | 2015-10-14 | Coloright Ltd | A method for predicting a result of a treatment of keratinous fibers |
US9844687B2 (en) | 2011-03-21 | 2017-12-19 | Coloright Ltd. | Systems for custom coloration |
US11095087B2 (en) | 2012-04-18 | 2021-08-17 | Cynosure, Llc | Picosecond laser apparatus and methods for treating target tissues with same |
US10581217B2 (en) | 2012-04-18 | 2020-03-03 | Cynosure, Llc | Picosecond laser apparatus and methods for treating target tissues with same |
US10305244B2 (en) | 2012-04-18 | 2019-05-28 | Cynosure, Llc | Picosecond laser apparatus and methods for treating target tissues with same |
US11664637B2 (en) | 2012-04-18 | 2023-05-30 | Cynosure, Llc | Picosecond laser apparatus and methods for treating target tissues with same |
US9780518B2 (en) | 2012-04-18 | 2017-10-03 | Cynosure, Inc. | Picosecond laser apparatus and methods for treating target tissues with same |
US11284801B2 (en) | 2012-06-21 | 2022-03-29 | Stryker European Operations Limited | Quantification and analysis of angiography and perfusion |
US10278585B2 (en) | 2012-06-21 | 2019-05-07 | Novadaq Technologies ULC | Quantification and analysis of angiography and perfusion |
US20160256707A1 (en) * | 2012-06-22 | 2016-09-08 | S & Y Enterprises Llc | Aesthetic treatment device and method |
US9962557B2 (en) * | 2012-06-22 | 2018-05-08 | S & Y Enterprises Llc | Aesthetic treatment device and method |
US9480529B2 (en) * | 2012-06-22 | 2016-11-01 | S & Y Enterprises Llc | Aesthetic treatment device and method |
US20130345685A1 (en) * | 2012-06-22 | 2013-12-26 | Epilady 2000, Llc | Aesthetic treatment device and method |
US10422743B2 (en) | 2012-11-13 | 2019-09-24 | Viavi Solutions Inc. | Spectrometer with a relay lightpipe |
US10285757B2 (en) | 2013-03-15 | 2019-05-14 | Cynosure, Llc | Picosecond optical radiation systems and methods of use |
US10245107B2 (en) | 2013-03-15 | 2019-04-02 | Cynosure, Inc. | Picosecond optical radiation systems and methods of use |
US11446086B2 (en) | 2013-03-15 | 2022-09-20 | Cynosure, Llc | Picosecond optical radiation systems and methods of use |
US10765478B2 (en) | 2013-03-15 | 2020-09-08 | Cynosurce, Llc | Picosecond optical radiation systems and methods of use |
US10302495B2 (en) | 2013-09-26 | 2019-05-28 | Coloright Ltd. | Hair reader, dispenser device and related systems and methods |
WO2015044944A2 (en) | 2013-09-26 | 2015-04-02 | Coloright Ltd. | Hair reader, dispenser device and related systems and methods |
EP3508254A1 (en) | 2013-09-26 | 2019-07-10 | Coloright Ltd. | System for preparing a hair coloring composition |
US10012588B2 (en) | 2014-04-27 | 2018-07-03 | Coloright Ltd. | Apparatus and method for customized hair-coloring |
US10806234B2 (en) | 2014-04-27 | 2020-10-20 | Coloright Ltd. | Apparatus and method for analyzing hair and/or predicting an outcome of a hair-coloring treatment |
US10416078B2 (en) | 2014-04-27 | 2019-09-17 | Coloright Ltd. | Apparatus and method for customized hair-coloring |
US11676276B2 (en) | 2014-07-24 | 2023-06-13 | University Health Network | Collection and analysis of data for diagnostic purposes |
US11954861B2 (en) | 2014-07-24 | 2024-04-09 | University Health Network | Systems, devices, and methods for visualization of tissue and collection and analysis of data regarding same |
US10438356B2 (en) | 2014-07-24 | 2019-10-08 | University Health Network | Collection and analysis of data for diagnostic purposes |
US9816930B2 (en) | 2014-09-29 | 2017-11-14 | Novadaq Technologies Inc. | Imaging a target fluorophore in a biological material in the presence of autofluorescence |
US10488340B2 (en) | 2014-09-29 | 2019-11-26 | Novadaq Technologies ULC | Imaging a target fluorophore in a biological material in the presence of autofluorescence |
US10631746B2 (en) | 2014-10-09 | 2020-04-28 | Novadaq Technologies ULC | Quantification of absolute blood flow in tissue using fluorescence-mediated photoplethysmography |
WO2016188350A1 (en) * | 2015-05-25 | 2016-12-01 | 高利通科技(深圳)有限公司 | Spectrum display method and system with photographic function |
WO2018127784A1 (en) | 2017-01-06 | 2018-07-12 | Coloright Ltd. | Hair-holder, hair-reader comprising the same, and methods for optically acquiring data from hair |
US11140305B2 (en) | 2017-02-10 | 2021-10-05 | Stryker European Operations Limited | Open-field handheld fluorescence imaging systems and methods |
US10992848B2 (en) | 2017-02-10 | 2021-04-27 | Novadaq Technologies ULC | Open-field handheld fluorescence imaging systems and methods |
US10632324B2 (en) | 2017-04-27 | 2020-04-28 | 9127-4910 Quebec Inc. | Method for the treatment of skin tissues |
US11280990B2 (en) | 2018-02-26 | 2022-03-22 | Caliber Imaging & Diagnostics, Inc. | System and method for macroscopic and microscopic imaging ex-vivo tissue |
US11418000B2 (en) | 2018-02-26 | 2022-08-16 | Cynosure, Llc | Q-switched cavity dumped sub-nanosecond laser |
US11681133B2 (en) | 2018-02-26 | 2023-06-20 | Caliber Imaging & Diagnostics, Inc. | System and method for macroscopic and microscopic imaging ex-vivo tissue |
US11791603B2 (en) | 2018-02-26 | 2023-10-17 | Cynosure, LLC. | Q-switched cavity dumped sub-nanosecond laser |
US11961236B2 (en) | 2023-06-13 | 2024-04-16 | University Health Network | Collection and analysis of data for diagnostic purposes |
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KR19980019193A (en) | 1998-06-05 |
CA2212396A1 (en) | 1998-02-28 |
AU3325297A (en) | 1998-03-05 |
EP0826335A1 (en) | 1998-03-04 |
AU717103B2 (en) | 2000-03-16 |
JPH1085222A (en) | 1998-04-07 |
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