US5443473A - Method for treating myopia - Google Patents
Method for treating myopia Download PDFInfo
- Publication number
- US5443473A US5443473A US08/117,153 US11715394A US5443473A US 5443473 A US5443473 A US 5443473A US 11715394 A US11715394 A US 11715394A US 5443473 A US5443473 A US 5443473A
- Authority
- US
- United States
- Prior art keywords
- cornea
- incision
- anterial
- lamina
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/147—Implants to be inserted in the stroma for refractive correction, e.g. ring-like implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/145—Corneal inlays, onlays, or lenses for refractive correction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/148—Implantation instruments specially adapted therefor
Definitions
- keratoprosthesis A modification of the radial keratomy procedure, called keratoprosthesis, was recently developed in the United States.
- a lamellar keratoplasty is performed in which only the superficial layer of the cornea is removed and replaced with a corneal implant. These implants are a replacement for the natural cornea where the cornea has become opaque-or fogged as may occur as the result of burns.
- This procedure if successful, also tends to flatten the cornea and hence remove the cause of the myopia.
- the lamellar keratoplasty is traumatic to the patient and the patient may experience difficulty during the healing process such as infection, epithelial cell granulations, scar tissue foundation and the like.
- a window is cut out of at least the damaged outer layer to permit the eye to see through the prosthesis. If the inner layer of the cornea is undamaged then it is only necessary to trephine the outer layer of the cornea leaving the aqueous humour separated from the surrounding air by the inner layer of the cornea backed by the keratoprosthesis. Should the inner layer of the cornea also be damaged then it too must be removed leaving the prosthesis as the only layer between the aqueous humour and the ambient air. Thus, the keratoprosthesis is always in contact with the air and is held in place by the portions of the natural cornea which remain only around its periphery.
- a shallow circular cut is made in the surface of the cornea of a myopic eye or those of the other refractive errors.
- the depth of the cut is limited so as to extend to just below the anterial lamina (Bowman's membrane) which maintains the curvature of the cornea.
- a small incision is then made in the cornea adjacent to the circular cut to a depth beneath the Bowman's membrane to gain entrance to the layer of cells and fibers positioned there.
- This layer which is approximately 200 fiber layers thick, has its fibers laid out in layers which can be separated from one another.
- a keratome or other surgical knife is inserted through the incision and used to separate the layers to form a pocket.
- An intrastromal implant in the form of a lens of a hydrogel is then introduced into the pocket. The incision is sealed by applying a biological glue or plaster to the site.
- the lens within the corneal stroma in conjunction with the severed Bowman's membrane serve to flatten and hold the cornea in a flattened state to correct the myopic condition or to modify the curvature for the other refractive errors.
- the trephine used to cut the Bowman's membrane and the keratome used to separate the lamella beneath the Bowman's membrane are provided with governors to limit their respective penetrations.
- FIG. 1 shows a cross-section of a cornea and trephine used to form a circular cut therein.
- FIG. 2 shows a cross-section of the cornea of FIG. 1 with a keratone inserted in an incision in the cornea.
- FIG. 3 shows a cross-section of a keratone which can be used to form a pocket in the cornea.
- the invention relates to a method for improving eyesight.
- the invention is directed to a method for treating myopia by altering the radius of curvature of the cornea.
- the accompanying drawings illustrate an eye operation for modifying the refractive index of the cornea.
- the method involves weakening the anterial laminar of the cornea and then inserting a intrastromal lens into a pocket in the cornea to modify the radius of curvature of the cornea.
- Incision 18 is then formed adjacent the circular cut formed with the trephine. Incision 18 extends to the lamella beneath the Bowman's membrane which is approximately 200 microns in thickness. The fibers of the lamella are laid out in layers which may be separated from each other. As shown in FIG. 2, a surgical knife or keratome 20 is inserted into the incision 18 to the layer below the Bowman's membrane and oscillated so as to form a pocket 22 in the lamella.
- the keratome 20 has a blunt tip and is generally designed similar to a spatula. Keratome 20 preferably has an irrigation tip through which a water jet 26 may flow to aid in separating the cell layers and open the tissue plane as shown in FIG. 3.
- the keratome 20 is further provided with a governor 30 which controls the depth of penetration and separation.
- the combination of the hydrogel lens 28 and the weakened Bowman's membrane 12 cooperate to flatten the cornea and thereby alter its radius of curvature. The change in the radius of curvature will correct the myopic condition.
Abstract
Description
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/117,153 US5443473A (en) | 1991-03-15 | 1992-03-15 | Method for treating myopia |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67034091A | 1991-03-15 | 1991-03-15 | |
PCT/US1992/002100 WO1992016172A1 (en) | 1991-03-15 | 1992-03-15 | Method and device for treating myopia |
US08/117,153 US5443473A (en) | 1991-03-15 | 1992-03-15 | Method for treating myopia |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US67034091A Continuation-In-Part | 1991-03-15 | 1991-03-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
US5443473A true US5443473A (en) | 1995-08-22 |
Family
ID=24690028
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/117,153 Expired - Fee Related US5443473A (en) | 1991-03-15 | 1992-03-15 | Method for treating myopia |
Country Status (3)
Country | Link |
---|---|
US (1) | US5443473A (en) |
AU (1) | AU1749592A (en) |
WO (1) | WO1992016172A1 (en) |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5941796A (en) * | 1994-04-08 | 1999-08-24 | Hyundai Motor Company Ltd. | Feedback control of the line pressure during a downshift |
US5964775A (en) * | 1993-10-12 | 1999-10-12 | New Jersey Institute Of Technology | Method and device for corneal shaping and refractive correction |
US5984961A (en) * | 1997-12-02 | 1999-11-16 | Macoul; Kenneth L. | Intracorneal prism and method of improving vision in a human eye having macula disease |
US6033418A (en) * | 1997-04-25 | 2000-03-07 | New Jersey Institute Of Technology | Method and device for corneal shaping and refractive correction |
US6051011A (en) * | 1997-08-28 | 2000-04-18 | Bausch & Lomb Surgical, Inc. | Surgical handpiece |
US6638917B1 (en) | 2000-02-25 | 2003-10-28 | Scimed Life Systems, Inc. | Reducing adhesion |
US20060020267A1 (en) * | 2004-07-15 | 2006-01-26 | Marmo J C | Intrastromal devices and methods for improving vision |
US20070093862A1 (en) * | 2001-11-09 | 2007-04-26 | Mcdonald Marguerite B | Surgical instruments and method for corneal reformation |
US20070208422A1 (en) * | 2006-01-26 | 2007-09-06 | Wake Forest University Health Sciences | Medical tools for facilitating deep lamellar endothelial keratoplasty and related methods |
US7585075B2 (en) | 2004-05-20 | 2009-09-08 | Forsight Labs, Llc | Corneal onlays and wavefront aberration correction to enhance vision |
US7828844B2 (en) * | 2002-09-13 | 2010-11-09 | Forsight Labs, Llc | Inserting lenses into corneal epithelial pockets to improve vision |
US7883520B2 (en) | 2006-04-10 | 2011-02-08 | Forsight Labs, Llc | Corneal epithelial pocket formation systems, components and methods |
US9974646B2 (en) | 2012-09-05 | 2018-05-22 | University Of Miami | Keratoprosthesis, and system and method of corneal repair using same |
WO2019135216A1 (en) | 2018-01-02 | 2019-07-11 | Cartiheal (2009) Ltd. | Implantation tool and protocol for optimized solid substrates promoting cell and tissue growth |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11259914B2 (en) | 2014-05-12 | 2022-03-01 | Gholam A. Peyman | Molding or 3-D printing of a synthetic refractive corneal lenslet |
US10881503B2 (en) | 2014-05-12 | 2021-01-05 | Gholam A. Peyman | Method of corneal transplantation or corneal inlay implantation with cross-linking |
US10709546B2 (en) | 2014-05-12 | 2020-07-14 | Gholam A. Peyman | Intracorneal lens implantation with a cross-linked cornea |
US9937033B1 (en) * | 2014-05-12 | 2018-04-10 | Gholam A. Peyman | Corneal lenslet implantation with a cross-linked cornea |
US10278920B1 (en) | 2014-05-12 | 2019-05-07 | Gholam A. Peyman | Drug delivery implant and a method using the same |
US10583221B2 (en) | 2014-05-12 | 2020-03-10 | Gholam A. Peyman | Method of corneal transplantation or corneal inlay implantation with cross-linking |
US10206569B1 (en) | 2014-05-12 | 2019-02-19 | Gholam A. Peyman | Corneal intraocular pressure sensor and a surgical method using the same |
US11565023B2 (en) | 2014-05-12 | 2023-01-31 | Gholam A. Peyman | Method of corneal transplantation or corneal inlay implantation with cross-linking |
US10195081B1 (en) | 2014-05-12 | 2019-02-05 | Gholam A. Peyman | Method of prevention of capsular opacification and fibrosis after cataract extraction and/or prevention of fibrosis around a shunt or stent after glaucoma surgery |
US11648261B2 (en) | 2014-05-12 | 2023-05-16 | Gholam A. Peyman | Method of treating, reducing, or alleviating a medical condition in a patient |
US11338059B2 (en) | 2014-05-12 | 2022-05-24 | Gholam A. Peyman | Method of corneal and scleral inlay crosslinking and preservation |
US11666777B2 (en) | 2014-05-12 | 2023-06-06 | Gholam A. Peyman | Photodynamic therapy technique for preventing damage to the fovea of the eye or another body portion of a patient |
US10314690B1 (en) | 2014-05-12 | 2019-06-11 | Gholam A. Peyman | Method of corneal transplantation or corneal inlay implantation with cross-linking |
US10925889B2 (en) | 2014-05-12 | 2021-02-23 | Gholam A. Peyman | Method of treating, reducing, or alleviating a medical condition in a patient |
US11045352B2 (en) | 2014-05-12 | 2021-06-29 | Gholam A. Peyman | Methods for treatment of dry eye and other acute or chronic inflammatory processes |
US11707518B2 (en) | 2019-04-28 | 2023-07-25 | Gholam A. Peyman | Method of treating, reducing, or alleviating a medical condition in a patient |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4607617A (en) * | 1980-08-05 | 1986-08-26 | Choyce David P | Apparatus and method for improving eyesight |
FR2631545A1 (en) * | 1988-05-19 | 1989-11-24 | Biodomi | Applicator for epicorneal implantation of flexible (soft) lenses |
US4959070A (en) * | 1987-04-27 | 1990-09-25 | Mcdonald Henry H | Intraocular lens implantation |
US4994081A (en) * | 1986-10-16 | 1991-02-19 | Cbs Lens | Method for locating on a cornea an artificial lens fabricated from a collagen-hydrogel for promoting epithelial cell growth |
-
1992
- 1992-03-15 AU AU17495/92A patent/AU1749592A/en not_active Abandoned
- 1992-03-15 US US08/117,153 patent/US5443473A/en not_active Expired - Fee Related
- 1992-03-15 WO PCT/US1992/002100 patent/WO1992016172A1/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4607617A (en) * | 1980-08-05 | 1986-08-26 | Choyce David P | Apparatus and method for improving eyesight |
US4994081A (en) * | 1986-10-16 | 1991-02-19 | Cbs Lens | Method for locating on a cornea an artificial lens fabricated from a collagen-hydrogel for promoting epithelial cell growth |
US4959070A (en) * | 1987-04-27 | 1990-09-25 | Mcdonald Henry H | Intraocular lens implantation |
FR2631545A1 (en) * | 1988-05-19 | 1989-11-24 | Biodomi | Applicator for epicorneal implantation of flexible (soft) lenses |
Non-Patent Citations (8)
Title |
---|
Beekhuis, W. H. and McCarey, B. E., "Hydration Stability of Intracorneal Hydrogel Implants," Investigative Opthalmology & Visual Science, 26:1634-1636 Nov., 1985. |
Beekhuis, W. H. and McCarey, B. E., Hydration Stability of Intracorneal Hydrogel Implants, Investigative Opthalmology & Visual Science, 26:1634 1636 Nov., 1985. * |
Biodomi, "Fexible lens epi-corneal implantation instrument--has spatula rotating about application pad inserting lens periphery in excision," (From Derwent Publications, Ltd., London, GB, 24 Nov. 1989) (Abstract No. from FR2631-545-A (Ref. AL, above)). |
Biodomi, Fexible lens epi corneal implantation instrument has spatula rotating about application pad inserting lens periphery in excision, (From Derwent Publications, Ltd., London, GB, 24 Nov. 1989) (Abstract No. from FR2631 545 A (Ref. AL, above)). * |
Choyce, P. D., "Update on Polysulfone Corneal Inlays," Cataract and Refractive Microsurgery, pp. 285-290. (1989). |
Choyce, P. D., Update on Polysulfone Corneal Inlays, Cataract and Refractive Microsurgery, pp. 285 290. (1989). * |
Werblin, T. P. et al., "Eight Years Experience with Permalens Intracorneal Lenses in Nonhuman Primates," Refractive & Corneal Surgery, 8:12-22 Jan./Feb. 1992. |
Werblin, T. P. et al., Eight Years Experience with Permalens Intracorneal Lenses in Nonhuman Primates, Refractive & Corneal Surgery, 8:12 22 Jan./Feb. 1992. * |
Cited By (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5964775A (en) * | 1993-10-12 | 1999-10-12 | New Jersey Institute Of Technology | Method and device for corneal shaping and refractive correction |
US5941796A (en) * | 1994-04-08 | 1999-08-24 | Hyundai Motor Company Ltd. | Feedback control of the line pressure during a downshift |
US6033418A (en) * | 1997-04-25 | 2000-03-07 | New Jersey Institute Of Technology | Method and device for corneal shaping and refractive correction |
US6051011A (en) * | 1997-08-28 | 2000-04-18 | Bausch & Lomb Surgical, Inc. | Surgical handpiece |
US5984961A (en) * | 1997-12-02 | 1999-11-16 | Macoul; Kenneth L. | Intracorneal prism and method of improving vision in a human eye having macula disease |
US6638917B1 (en) | 2000-02-25 | 2003-10-28 | Scimed Life Systems, Inc. | Reducing adhesion |
US6693089B1 (en) | 2000-02-25 | 2004-02-17 | Scimed Life Systems, Inc. | Reducing adhesion |
US20070093862A1 (en) * | 2001-11-09 | 2007-04-26 | Mcdonald Marguerite B | Surgical instruments and method for corneal reformation |
US7828844B2 (en) * | 2002-09-13 | 2010-11-09 | Forsight Labs, Llc | Inserting lenses into corneal epithelial pockets to improve vision |
US7585075B2 (en) | 2004-05-20 | 2009-09-08 | Forsight Labs, Llc | Corneal onlays and wavefront aberration correction to enhance vision |
US20060020267A1 (en) * | 2004-07-15 | 2006-01-26 | Marmo J C | Intrastromal devices and methods for improving vision |
US20070208422A1 (en) * | 2006-01-26 | 2007-09-06 | Wake Forest University Health Sciences | Medical tools for facilitating deep lamellar endothelial keratoplasty and related methods |
US8470029B2 (en) | 2006-01-26 | 2013-06-25 | Wake Forest University Health Sciences | Medical tools for facilitating deep lamellar endothelial keratoplasty and related methods |
US8673002B2 (en) | 2006-01-26 | 2014-03-18 | Wake Forest University Health Science | Medical tools for facilitating keratoplasty and related methods |
US9433495B2 (en) | 2006-01-26 | 2016-09-06 | Wake Forest University Health Sciences | Medical tools for small incision eye surgery |
US10258461B2 (en) | 2006-01-26 | 2019-04-16 | Wake Forest University Health Sciences | Medical kits and methods for small incision eye surgery |
US10959835B2 (en) | 2006-01-26 | 2021-03-30 | Wake Forest University Health Sciences | Medical kits and methods for small incision eye surgery |
US11806228B2 (en) | 2006-01-26 | 2023-11-07 | Wake Forest University Health Sciences | Methods for small incision eye surgery |
US7883520B2 (en) | 2006-04-10 | 2011-02-08 | Forsight Labs, Llc | Corneal epithelial pocket formation systems, components and methods |
US9974646B2 (en) | 2012-09-05 | 2018-05-22 | University Of Miami | Keratoprosthesis, and system and method of corneal repair using same |
WO2019135216A1 (en) | 2018-01-02 | 2019-07-11 | Cartiheal (2009) Ltd. | Implantation tool and protocol for optimized solid substrates promoting cell and tissue growth |
Also Published As
Publication number | Publication date |
---|---|
AU1749592A (en) | 1992-10-21 |
WO1992016172A1 (en) | 1992-10-01 |
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