US5413908A - Method of characterizing genomic DNA by reference to a genetic variable - Google Patents

Method of characterizing genomic DNA by reference to a genetic variable Download PDF

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US5413908A
US5413908A US07/921,375 US92137592A US5413908A US 5413908 A US5413908 A US 5413908A US 92137592 A US92137592 A US 92137592A US 5413908 A US5413908 A US 5413908A
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dna
fragments
sequence
core
probe
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Alec J. Jeffreys
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Lister Institute of Preventive Medicine
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Lister Institute of Preventive Medicine
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Priority claimed from GB848428491A external-priority patent/GB8428491D0/en
Priority claimed from GB858505744A external-priority patent/GB8505744D0/en
Priority claimed from GB858518755A external-priority patent/GB8518755D0/en
Priority claimed from GB858522135A external-priority patent/GB8522135D0/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes
US07/921,375 1984-11-12 1992-07-29 Method of characterizing genomic DNA by reference to a genetic variable Expired - Lifetime US5413908A (en)

Priority Applications (1)

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US07/921,375 US5413908A (en) 1984-11-12 1992-07-29 Method of characterizing genomic DNA by reference to a genetic variable

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
GB848428491A GB8428491D0 (en) 1984-11-12 1984-11-12 Polynucleotide probes
GB8428491 1984-11-12
GB858505744A GB8505744D0 (en) 1985-03-06 1985-03-06 Repeat sequence dna
GB8505744 1985-03-06
GB8518755 1985-07-24
GB858518755A GB8518755D0 (en) 1985-07-24 1985-07-24 Repeat sequence dna
GB8522135 1985-09-06
GB858522135A GB8522135D0 (en) 1985-09-06 1985-09-06 Repeat sequence dna
US78379085A 1985-10-03 1985-10-03
US22852388A 1988-08-04 1988-08-04
US07/921,375 US5413908A (en) 1984-11-12 1992-07-29 Method of characterizing genomic DNA by reference to a genetic variable

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US22852388A Continuation 1984-11-12 1988-08-04

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US5413908A true US5413908A (en) 1995-05-09

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EP (1) EP0186271B1 (zh)
JP (1) JP2750228B2 (zh)
KR (1) KR880700078A (zh)
CN (1) CN1014429B (zh)
AU (1) AU581582B2 (zh)
BR (1) BR8507049A (zh)
CY (1) CY1427A (zh)
DE (2) DE3584957D1 (zh)
DK (1) DK331886A (zh)
ES (1) ES8800349A1 (zh)
FI (1) FI862915A0 (zh)
GB (1) GB2166445B (zh)
GR (1) GR852708B (zh)
HK (1) HK13989A (zh)
HU (1) HU203795B (zh)
IE (1) IE62864B1 (zh)
IL (1) IL76668A0 (zh)
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MY (1) MY102570A (zh)
NO (1) NO862825L (zh)
NZ (1) NZ213762A (zh)
PL (1) PL256209A1 (zh)
PT (1) PT81468B (zh)
SG (1) SG12688G (zh)
WO (1) WO1986002948A1 (zh)
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US6306588B1 (en) 1997-02-07 2001-10-23 Invitrogen Corporation Polymerases for analyzing or typing polymorphic nucleic acid fragments and uses thereof
WO2002094185A2 (en) * 2001-05-18 2002-11-28 Sirna Therapeutics, Inc. Conjugates and compositions for cellular delivery
US6528256B1 (en) 1996-08-30 2003-03-04 Invitrogen Corporation Methods for identification and isolation of specific nucleotide sequences in cDNA and genomic DNA
US6593091B2 (en) 2001-09-24 2003-07-15 Beckman Coulter, Inc. Oligonucleotide probes for detecting nucleic acids through changes in flourescence resonance energy transfer
US6596487B2 (en) 2000-03-10 2003-07-22 Ana-Gen Technologies, Inc. Mutation detection using denaturing gradients
US20030172065A1 (en) * 2001-03-30 2003-09-11 Sorenson James L. System and method for molecular genealogical research
KR100459106B1 (ko) * 2002-03-21 2004-12-03 한국해양연구원 시간 유전자 인트론의 염기서열을 ｄｎａ 지문으로 이용한생물체 식별 방법
US20050124566A1 (en) * 2001-05-18 2005-06-09 Sirna Therapeutics, Inc. RNA interference mediated inhibition of myostatin gene expression using short interfering nucleic acid (siNA)
US20050159382A1 (en) * 2001-05-18 2005-07-21 Sirna Therapeutics, Inc. RNA interference mediated inhibition of polycomb group protein EZH2 gene expression using short interfering nucleic acid (siNA)
US20050158735A1 (en) * 2001-05-18 2005-07-21 Sirna Therapeutics, Inc. RNA interference mediated inhibition of proliferating cell nuclear antigen (PCNA) gene expression using short interfering nucleic acid (siNA)
US20050159381A1 (en) * 2001-05-18 2005-07-21 Sirna Therapeutics, Inc. RNA interference mediated inhibition of chromosome translocation gene expression using short interfering nucleic acid (siNA)
US20050176025A1 (en) * 2001-05-18 2005-08-11 Sirna Therapeutics, Inc. RNA interference mediated inhibition of B-cell CLL/Lymphoma-2 (BCL-2) gene expression using short interfering nucleic acid (siNA)
US20050196767A1 (en) * 2001-05-18 2005-09-08 Sirna Therapeutics, Inc. RNA interference mediated inhibition of GRB2 associated binding protein (GAB2) gene expression using short interfering nucleic acis (siNA)
US20050203040A1 (en) * 2001-05-18 2005-09-15 Sirna Therapeutics, Inc. RNA interference mediated inhibition of vascular cell adhesion molecule (VCAM) gene expression using short interfering nucleic acid (siNA)
US20050233997A1 (en) * 2001-05-18 2005-10-20 Sirna Therapeutics, Inc. RNA interference mediated inhibition of matrix metalloproteinase 13 (MMP13) gene expression using short interfering nucleic acid (siNA)
US20050288242A1 (en) * 2001-05-18 2005-12-29 Sirna Therapeutics, Inc. RNA interference mediated inhibition of RAS gene expression using short interfering nucleic acid (siNA)
US20060216747A1 (en) * 2001-05-18 2006-09-28 Sirna Therapeutics, Inc. RNA interference mediated inhibition of checkpoint kinase-1 (CHK-1) gene expression using short interfering nucleic acid (siNA)
US20070178489A1 (en) * 1999-05-12 2007-08-02 Invitrogen Corporation Compositions and Methods for Enhanced Sensitivity and Specificity of Nucleic Acid Synthesis
US20070266003A1 (en) * 2006-05-09 2007-11-15 0752004 B.C. Ltd. Method and system for constructing dynamic and interacive family trees based upon an online social network
US20080081331A1 (en) * 2006-10-02 2008-04-03 Myres Natalie M Method and system for displaying genetic and genealogical data
US20080130778A1 (en) * 2006-12-04 2008-06-05 Samsung Electronics Co., Ltd. System and method for wireless communication of uncompressed high definition video data using a transfer matrix for beamforming estimation
US20080189047A1 (en) * 2006-11-01 2008-08-07 0752004 B.C. Ltd. Method and system for genetic research using genetic sampling via an interactive online network
WO2005055805A3 (en) * 2003-12-02 2009-04-02 Shraga Rottem An artificial intelligence and device for diagnosis, screening, prevention and treatment of materno-fetal conditions
US9181551B2 (en) 2002-02-20 2015-11-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US9260471B2 (en) 2010-10-29 2016-02-16 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
US9657294B2 (en) 2002-02-20 2017-05-23 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US20180355425A1 (en) * 2015-08-27 2018-12-13 Nuhigh Biotechnologies Co., Ltd. Molecular weight internal standard and applications thereof
US11238957B2 (en) 2018-04-05 2022-02-01 Ancestry.Com Dna, Llc Community assignments in identity by descent networks and genetic variant origination
US11631477B2 (en) 2017-09-07 2023-04-18 Dmitry Shvartsman System and method for authenticated exchange of biosamples

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FR2603047B1 (fr) * 1986-08-19 1990-03-02 Vassart Gilbert Sonde d'hybridation pour la detection de sequences nucleotidiques polymorphes contenues dans un echantillon d'adn humain ou animal, procede de detection de sequences d'adn polymorphes utilisant une telle sonde, ses applications biologiques
US4987066A (en) * 1986-11-07 1991-01-22 Max Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Process for the detection of restriction fragment length polymorphisms in eukaryotic genomes
EP0294098A1 (en) * 1987-05-29 1988-12-07 City Of Hope Synthetic DNA probes
US4880750A (en) * 1987-07-09 1989-11-14 Miragen, Inc. Individual-specific antibody identification methods
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US5064948A (en) * 1988-02-12 1991-11-12 The United States Of America As Represented By The Department Of Energy Chromosome specific repetitive dna sequences
JPH05501946A (ja) * 1988-02-18 1993-04-15 ユニバーシティ・オブ・ユタ 可変数タンデム反復座のｄｎａプローブを使用する遺伝的同定
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NZ225513A (en) * 1988-07-21 1990-11-27 Nz Scientific & Ind Res Biotech Div Polynucleotides useful for identifying polymorphism in animals by genetic fingerprinting
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US5766847A (en) * 1988-10-11 1998-06-16 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Process for analyzing length polymorphisms in DNA regions
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