US5340588A - Liposphere carriers of vaccines - Google Patents
Liposphere carriers of vaccines Download PDFInfo
- Publication number
- US5340588A US5340588A US07/825,287 US82528792A US5340588A US 5340588 A US5340588 A US 5340588A US 82528792 A US82528792 A US 82528792A US 5340588 A US5340588 A US 5340588A
- Authority
- US
- United States
- Prior art keywords
- antigen
- liposphere
- phospholipid
- lipospheres
- solid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/812—Liposome comprising an antibody, antibody fragment, antigen, or other specific or nonspecific immunoeffector
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (31)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/825,287 US5340588A (en) | 1989-11-13 | 1992-01-23 | Liposphere carriers of vaccines |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43554689A | 1989-11-13 | 1989-11-13 | |
US60754490A | 1990-11-08 | 1990-11-08 | |
US60754290A | 1990-11-08 | 1990-11-08 | |
US60754390A | 1990-11-08 | 1990-11-08 | |
US07/825,287 US5340588A (en) | 1989-11-13 | 1992-01-23 | Liposphere carriers of vaccines |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US60754490A Continuation | 1989-11-13 | 1990-11-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
US5340588A true US5340588A (en) | 1994-08-23 |
Family
ID=27503844
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US07/825,287 Expired - Lifetime US5340588A (en) | 1989-11-13 | 1992-01-23 | Liposphere carriers of vaccines |
Country Status (2)
Country | Link |
---|---|
US (1) | US5340588A (en) |
IE (1) | IE904098A1 (en) |
Cited By (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996014871A1 (en) * | 1994-11-15 | 1996-05-23 | Cortecs Limited | Immunogenic compositions |
WO1998029121A1 (en) * | 1997-01-02 | 1998-07-09 | Thomas Jefferson University | A method of modulating an immune response in an infected mammal by transmucosal administration of modulating agent |
US5910306A (en) * | 1996-11-14 | 1999-06-08 | The United States Of America As Represented By The Secretary Of The Army | Transdermal delivery system for antigen |
US5919466A (en) * | 1993-10-01 | 1999-07-06 | Gerbu Biotechnik Gmbh | Method for improving the yield of immunoantibodies in the vaccination of animals and humans |
US5980898A (en) * | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
US5993852A (en) * | 1997-08-29 | 1999-11-30 | Pharmaderm Laboratories Ltd. | Biphasic lipid vesicle composition for transdermal administration of an immunogen |
US6245349B1 (en) | 1996-02-23 | 2001-06-12 | éLAN CORPORATION PLC | Drug delivery compositions suitable for intravenous injection |
US6284375B1 (en) | 1996-10-18 | 2001-09-04 | Tuo Jin | Lipid vesicle system |
US20020110568A1 (en) * | 2000-11-07 | 2002-08-15 | Brown Robert George | Vaccines with enhanced immune response and methods for their preparation |
KR100359252B1 (en) * | 1999-12-21 | 2002-11-04 | 주식회사 엘지생명과학 | Solid microparticle comprising antigen and preparation comprising same |
US6645192B2 (en) * | 1998-09-30 | 2003-11-11 | Ivy Animal Health, Inc. | Pellet implant system for immediate and delayed release of antiparasitic drug |
US6676958B2 (en) * | 2001-06-19 | 2004-01-13 | Advanced Bioadjuvants, Llc | Adjuvant composition for mucosal and injection delivered vaccines |
US6692767B2 (en) | 1997-09-19 | 2004-02-17 | Shire Laboratories Inc. | Solid solution beadlet |
US20040081688A1 (en) * | 2000-12-27 | 2004-04-29 | Del Curto Maria Dorly | Amphiphilic lipid nanoparticles for peptide and/or protein incorporation |
US20040091522A1 (en) * | 2000-12-27 | 2004-05-13 | Del Curto Maria Dorly | Lipid microparticles by cryogenic micronization |
EP1420818A1 (en) * | 2001-07-26 | 2004-05-26 | Otago Innovation Limited | Antigenic compositions |
US6797276B1 (en) | 1996-11-14 | 2004-09-28 | The United States Of America As Represented By The Secretary Of The Army | Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response |
US20040213837A1 (en) * | 2002-08-05 | 2004-10-28 | Sankaram Mantripragada | Oil-core compositions for the sustained release of hydrophobic drugs |
AU2002300572B2 (en) * | 1997-09-19 | 2004-11-25 | Shire Laboratories, Inc. | Solid Solution Beadlet |
US20040247604A1 (en) * | 2001-04-11 | 2004-12-09 | Cohen Irun R. | Anti-inflamatory fatty alcohols and fatty acid esters useful as antigen carriers |
US20060017463A1 (en) * | 2004-06-15 | 2006-01-26 | Stmicroelectronics Pvt. Ltd. | Differential receiver |
US7026290B1 (en) | 1998-12-30 | 2006-04-11 | Dexcel Ltd. | Dispersible concentrate for the delivery of cyclosprin |
US20060173053A1 (en) * | 2002-10-10 | 2006-08-03 | Meir Shinitzky | Basic esters of fatty alcohols and their use as anti-inflammatory or immunomodulatory agents |
US20060177495A1 (en) * | 2001-12-21 | 2006-08-10 | Christine Allen | Polymer-lipid delivery vehicles |
US20060183797A1 (en) * | 2001-04-11 | 2006-08-17 | Cohen Irun R | Fatty alcohols and fatty acid esters useful for treatment of inflammation |
US20080160058A1 (en) * | 2006-09-19 | 2008-07-03 | Applied Biotechnologies Pty.Ltd. | bait and uses thereof |
US20080221209A1 (en) * | 2007-02-26 | 2008-09-11 | Yaacov Herzig | Enantiomers of amino-phenyl-acetic acid octadec-9-(z) enyl ester, their salts and their uses |
US20080292663A1 (en) * | 2007-05-22 | 2008-11-27 | Gerber Jay D | Adjuvant compositions and methods for delivering vaccines |
US20080305348A1 (en) * | 2007-06-11 | 2008-12-11 | Spedden Richard H | Solid State Membranes with Surface-Embedded Glycosylated Amphiphilic Molecules and Micelles Formed Therefrom |
US7527802B2 (en) | 2001-02-13 | 2009-05-05 | The United States Of America As Represented By The Secretary Of The Army | Vaccine for transcutaneous immunization |
US20090297593A1 (en) * | 2005-10-07 | 2009-12-03 | Immunovaccine Technologies Inc. | Use of Liposomes in a Carrier Comprising a Continuous Hydrophobic Phase as a Vehicle for Cancer Treatment |
US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
US20100203116A1 (en) * | 2007-09-27 | 2010-08-12 | Marc Mansour | Use of liposomes in a carrier comprising a continuous hydrophobic phase for delivery of polynucleotides in vivo |
US20100209452A1 (en) * | 2007-10-03 | 2010-08-19 | Immunovaccine Technologies, Inc | Compositions comprising an antigen, an amphipathic compound and a hydrophobic carrier, and uses thereof |
US20110070298A1 (en) * | 2008-06-05 | 2011-03-24 | Immunovaccine Technologies Inc. | Compositions Comprising Liposomes, An Antigen, A Polynucleotide and A Carrier Comprising a Continuous Phase of a Hydrophobic Substance |
US8518431B2 (en) | 2008-08-07 | 2013-08-27 | Bioactive Surgical, Inc. | Stem cell capture and immobilization coatings for medical devices and implants |
EP2663288A1 (en) * | 2011-01-13 | 2013-11-20 | Variation Biotechnologies Inc. | Methods for preparing vesicles and formulations produced therefrom |
US8911742B2 (en) | 1996-11-14 | 2014-12-16 | The United States Of America As Represented By The Secretary Of The Army | Transcutaneous immunization without heterologous adjuvant |
US8957053B2 (en) | 2012-05-09 | 2015-02-17 | Tesorx Pharma, Llc | Proliposomal testosterone formulations |
US9610248B2 (en) | 2010-07-06 | 2017-04-04 | Variation Biotechnologies, Inc. | Compositions and methods for treating influenza |
US9849173B2 (en) | 2009-07-06 | 2017-12-26 | Variation Biotechnologies Inc. | Methods for preparing vesicles and formulations produced therefrom |
US9907746B2 (en) | 2009-07-06 | 2018-03-06 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
US10105435B2 (en) | 2011-10-06 | 2018-10-23 | Immunovaccine Technologies Inc. | Liposome compositions comprising an adjuvant that activates or increases the activity of TLR2 and uses thereof |
US10736844B2 (en) | 2011-01-13 | 2020-08-11 | Variation Biotechnologies Inc. | Compositions and methods for treating viral infections |
CN113499321A (en) * | 2021-06-10 | 2021-10-15 | 南方医科大学 | Micro motor carrier and preparation method and application thereof |
US11167032B2 (en) | 2012-01-27 | 2021-11-09 | Variation Biotechnologies Inc. | Methods and compositions for therapeutic agents |
US11167033B2 (en) | 2012-01-12 | 2021-11-09 | Variation Biotechnologies Inc. | Compositions and methods for treating viral infections |
Citations (62)
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US3004892A (en) * | 1959-03-27 | 1961-10-17 | Baxter Don Inc | Fat emulsion and process of producing same |
US3159545A (en) * | 1960-10-04 | 1964-12-01 | Abbott Lab | Radioactive capsules |
US3159600A (en) * | 1960-10-13 | 1964-12-01 | Minnesota Mining & Mfg | Reaction product of hydroxy siloxanes and polyalkylenimines |
US3804776A (en) * | 1970-12-14 | 1974-04-16 | Fuji Photo Film Co Ltd | Method of producing oil and fat encapsulated amino acids |
US3957971A (en) * | 1974-07-29 | 1976-05-18 | Lever Brothers Company | Moisturizing units and moisturizing compositions containing the same |
DE2601207A1 (en) * | 1975-01-27 | 1976-07-29 | Tanabe Seiyaku Co | PROCESS FOR MANUFACTURING A LIQUID PREPARATION WITH CONTROLLED DISPENSING CAPACITY |
US3993754A (en) * | 1974-10-09 | 1976-11-23 | The United States Of America As Represented By The United States Energy Research And Development Administration | Liposome-encapsulated actinomycin for cancer chemotherapy |
US4010038A (en) * | 1974-04-10 | 1977-03-01 | Kanzaki Paper Manufacturing Co., Ltd. | Process for producing microcapsules |
US4025455A (en) * | 1974-06-19 | 1977-05-24 | The Mead Corporation | Cross-linked hydroxypropylcellulose microcapsules and process for making |
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US4911928A (en) * | 1987-03-13 | 1990-03-27 | Micro-Pak, Inc. | Paucilamellar lipid vesicles |
US4914084A (en) * | 1984-05-09 | 1990-04-03 | Synthetic Blood Corporation | Composition and method for introducing heme, hemoproteins, and/or heme-hemoprotein complexes into the body |
US4929508A (en) * | 1984-10-05 | 1990-05-29 | Warner-Lambert Company | Novel drug delivery system for antitussives |
US4933183A (en) * | 1984-10-05 | 1990-06-12 | Warner-Lambert Company | Novel drug delivery system for mineral supplements |
US4935242A (en) * | 1984-10-05 | 1990-06-19 | Warner-Lambert Company | Novel drug delivery system for expectorants |
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-
1990
- 1990-11-13 IE IE409890A patent/IE904098A1/en not_active IP Right Cessation
-
1992
- 1992-01-23 US US07/825,287 patent/US5340588A/en not_active Expired - Lifetime
Patent Citations (66)
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US3004892A (en) * | 1959-03-27 | 1961-10-17 | Baxter Don Inc | Fat emulsion and process of producing same |
US3159545A (en) * | 1960-10-04 | 1964-12-01 | Abbott Lab | Radioactive capsules |
US3159600A (en) * | 1960-10-13 | 1964-12-01 | Minnesota Mining & Mfg | Reaction product of hydroxy siloxanes and polyalkylenimines |
US3804776A (en) * | 1970-12-14 | 1974-04-16 | Fuji Photo Film Co Ltd | Method of producing oil and fat encapsulated amino acids |
US4029762A (en) * | 1971-11-17 | 1977-06-14 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Lipid A-preparation |
US4010038A (en) * | 1974-04-10 | 1977-03-01 | Kanzaki Paper Manufacturing Co., Ltd. | Process for producing microcapsules |
US4025455A (en) * | 1974-06-19 | 1977-05-24 | The Mead Corporation | Cross-linked hydroxypropylcellulose microcapsules and process for making |
US4089801A (en) * | 1974-07-19 | 1978-05-16 | Battelle Memorial Institute | Process for the preparation of liposomes |
US3957971A (en) * | 1974-07-29 | 1976-05-18 | Lever Brothers Company | Moisturizing units and moisturizing compositions containing the same |
US3993754A (en) * | 1974-10-09 | 1976-11-23 | The United States Of America As Represented By The United States Energy Research And Development Administration | Liposome-encapsulated actinomycin for cancer chemotherapy |
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US4168308A (en) * | 1976-03-12 | 1979-09-18 | Apoteksvarucentralen Vitrum Ab | Composition for enhancing the administration of pharmacologically active agents |
US4145410A (en) * | 1976-10-12 | 1979-03-20 | Sears Barry D | Method of preparing a controlled-release pharmaceutical preparation, and resulting composition |
US4224179A (en) * | 1977-08-05 | 1980-09-23 | Battelle Memorial Institute | Process for the preparation of liposomes in aqueous solution |
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